Cosmetic containing adenosine

Abstract

The present invention relates to an aqueous, sprayable hair tonic having a pH value of 3.0 to 7.0 at 20°C, comprising urea and / or urea derivatives in a total amount of 1.0 to 20% by weight, adenosine in an amount of 0.05 to 3% by weight, and a buffer system for stabilizing the pH value, wherein the hair tonic comprises less than 18% by weight, preferably not more than 10% by weight, in particular not more than 5% by weight of ethanol; and the use of a sprayable aqueous preparation containing adenosine and urea and / or urea derivatives having an ethanol content of less than 18% by weight for cosmetic treatment of the skin, in particular the scalp.

Description

[0001] This invention relates to the field of hair care products (Haartonika). It comprises a sprayable, water-based product containing adenosine and having skin and hair conditioning effects.

[0002] This invention relates to hair conditioning agents with hair-conditioning effects (such as preventing hair loss and promoting hair growth). Adenosine is an active ingredient used in various cosmetic formulations (such as hair conditioning agents) to prevent hair loss and promote hair growth. Such products are preferably sprayed onto the scalp and hair for easy application and should be applicable without making the hair heavy.

[0003] The goal is to use high concentrations of adenosine in these products to achieve satisfactory results for users. Currently, high concentrations of adenosine (0.1% to 1.5% by weight) are only available in sprayable products with an ethanol content of at least 20% by weight. Adenosine cannot be stably incorporated into sprayable products with lower ethanol contents. However, products with such high ethanol content cause severe scalp dryness and faster fading of dyed hair. Therefore, products that overcome these drawbacks are desired.

[0004] Therefore, the object of the present invention is to provide a stable sprayable aqueous product in which adenosine is present in a high concentration and the product does not dry out the scalp.

[0005] Surprisingly, this objective can be achieved using a composition containing urea or urea derivatives and adenosine, and the pH of the composition is stabilized by a buffer system.

[0006] Therefore, the first subject of this application is an aqueous sprayable hair conditioner having a pH value of 3.0 to 7.0 at 20°C, comprising a total amount of 1.0 to 20% by weight of urea and / or urea derivatives, an amount of 0.05 to 3% by weight of adenosine, and a buffer system for stabilizing the pH value, characterized in that the hair conditioner contains less than 18% by weight, preferably no more than 10% by weight, and particularly no more than 5% by weight of ethanol.

[0007] Urea derivatives can be used in combination with urea or in place of urea to maintain a total amount of 1.0 to 20% by weight. If a urea derivative is used, it is preferably 2-hydroxyethylurea. In these cases, the amount of 2-hydroxyethylurea is preferably 1.0 to 15% by weight, particularly preferably 2.0 to 7.0% by weight, and especially 2.0 to 5.0% by weight. Preferably, 2-hydroxyethylurea is used in combination with urea. In these cases, the preferred amount of urea is 0.05 to 3.0% by weight, particularly preferably 0.1 to 1.0% by weight, and especially 0.1 to 0.5% by weight, and the preferred amount of 2-hydroxyethylurea is 1.0 to 15% by weight, particularly preferably 1.5 to 7% by weight, and especially 2.0 to 5.0% by weight. In such combinations, the ratio of 2-hydroxyethylurea to urea is particularly preferably 20:1 to 10:1.

[0008] Therefore, the preferred subject is the aforementioned hair growth agent, wherein the urea derivative is 2-hydroxyethylurea.

[0009] Another preferred subject is the aforementioned hair growth agent, wherein the total amount of urea and / or urea derivatives is 1.0 to 15% by weight, preferably 2.0 to 7.0% by weight, more preferably 2.0 to 5.0% by weight.

[0010] The claimed hair care product contains 0.05 to 3% by weight of adenosine. Adenosine is a nucleotide and consists of the nucleobase adenine and the sugar β-D-ribose. Preferred products contain 0.1 to 2% by weight, particularly 0.1 to 1% by weight of adenosine. Furthermore, products containing 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight of adenosine, are also preferred.

[0011] Therefore, hair growth products containing 0.1 to 2% by weight, particularly 0.1 to 1% by weight, adenosine are preferred.

[0012] The claimed hair growth product contains adenosine as an active ingredient. The hair growth product may also contain adenosine derivatives, such as adenosine 5'-phosphate. Preferably, the claimed product contains only a limited amount of adenosine derivatives, such as adenosine 5'-phosphate, for example, adenosine monophosphate (INCI: adenosine monophosphate), adenosine diphosphate, and / or adenosine triphosphate (INCI: adenosine triphosphate). Preferably, the product contains less than 0.5% by weight, particularly preferably less than 0.2% by weight, and especially less than 0.1% by weight of adenosine monophosphate. In particular, it may be preferred that the product is free of adenosine monophosphate. In this context, "free of adenosine monophosphate" means that adenosine monophosphate is neither added as a separate ingredient nor introduced into the claimed product through formulations of other ingredients, for example, in an amount not exceeding 0.001% by weight based on the total mass of the product.

[0013] The claimed compositions are stabilized by a buffer system. In particular, this allows for storage at elevated temperatures (e.g., 40°C). The buffer substance and its concentration are preferably selected to stabilize the active ingredient contained in the aqueous composition. Stabilization can also occur at elevated temperatures (e.g., 40°C); all pH values ​​described in this application are applicable to measurements at 20°C. Any type of buffer system suitable for cosmetics can be used to stabilize the desired pH range and maintain the pH in the range of 3.0 to 7.0, preferably 4.0 to 6.0, and particularly 4.2 to 5.5. This is preferably a lactate / lactate buffer, such as one containing sodium lactate, or a citrate / disodium hydrogen phosphate buffer.

[0014] If a lactate / sodium lactate buffer solution is used, different concentrations are possible. Preferably, based on the total composition, the concentration of lactate is 0.5 to 3.5% by weight, and the concentration of sodium lactate is 1.5 to 20% by weight. In particular, it is preferred that within this range, the ratio of lactate to sodium lactate is 0.02 to 2.3.

[0015] For some subjects, based on the total composition, the concentration of lactic acid is preferably 0.5 to 2% by weight, and the concentration of sodium lactate is 1.5 to 2.5% by weight. In particular, it is preferred that the ratio of lactic acid to sodium lactate is 0.3 to 0.8 within this range. For other subjects, based on the total composition, the concentration of lactic acid is preferably 2 to 3% by weight, particularly preferably 2.2 to 2.6% by weight, and the concentration of sodium lactate is 13 to 20% by weight, particularly preferably 15.5 to 17.0% by weight. In particular, it is preferred that the ratio of lactic acid to sodium lactate is 0.1 to 0.2 within this range.

[0016] If a citrate / disodium hydrogen phosphate buffer solution is used, the concentration of citrate monohydrate is preferably 0.5 to 1.5% by weight, and the concentration of disodium hydrogen phosphate dihydrate is preferably 0.8 to 2.5% by weight, based on the total composition. If citrate and / or disodium hydrogen phosphate are used in anhydrous form, the concentrations must be reduced accordingly.

[0017] In particular, it is preferred that the ratio of citric acid monohydrate to disodium hydrogen phosphate dihydrate is 0.2 to 2.0 within this range.

[0018] Therefore, it is preferred that the claimed hair care product contains a lactate / sodium lactate buffer solution, which stabilizes the pH of the product and maintains the pH in the range of 3.0 to 7.0, preferably 4.0 to 6.0, and particularly 4.2 to 5.5.

[0019] For other products for which protection is claimed, it is also preferred that the hair growth agent contains a citrate / disodium hydrogen phosphate buffer solution, which stabilizes the pH of the product and maintains the pH in the range of 3.0 to 7.0, preferably 4.0 to 6.0, and particularly 4.2 to 5.5.

[0020] Preferably, the previously specified amount of buffering material is used in all subsequent compositions, thereby enabling them to achieve the stated purpose.

[0021] The claimed hair growth agent contains less than 18% by weight, preferably no more than 10% by weight, and particularly no more than 5% by weight of ethanol. A preferred subject is the hair growth agent as described above containing 5.0 to 10.0% by weight of ethanol. Another preferred subject is the hair growth agent as described above, which contains no more than 5% by weight, particularly preferably less than 1% by weight, and especially preferably less than 0.5% by weight of ethanol, or is ethanol-free. In this context, ethanol-free means that ethanol is neither added as a separate ingredient nor introduced into the claimed product through formulations of other ingredients, for example, in an amount not exceeding 2% by weight based on the total mass of the product.

[0022] Therefore, the preferred subject is an aqueous sprayable hair conditioner having a pH value of 3.0 to 7.0 at 20°C, comprising: 1.0 to 20% by weight of urea and / or urea derivatives, 0.05 to 3% by weight of adenosine, 5.0 to 10% by weight of ethanol, and a buffer system for stabilizing the pH value.

[0023] Therefore, a further preferred subject is an aqueous sprayable hair conditioner having a pH value of 3.0 to 7.0 at 20°C, comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight of urea and / or 2-hydroxyethylurea, 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight of adenosine, 5.0 to 10% by weight of ethanol, and a buffer system for stabilizing the pH value.

[0024] The claimed water-based sprayable hair conditioner can be easily applied to the relevant area by the user because it is sprayable and therefore can be distributed finely and evenly. To ensure good sprayability, the hair treatment composition according to the invention preferably does not contain viscosity-increasing ingredients (such as polyquaternium polymers known as INCI names polyquaternium-10 and polyquaternium-37), provided that this is economical to operate (i.e., provided that small amounts of the corresponding substances are not introduced as trace components or impurities as industrial standard ingredients). Based on the total weight of the hair treatment composition, such viscosity-increasing ingredients and similar ingredients are preferably included in the hair treatment agent according to the invention in an amount of no more than 2% by weight, more preferably no more than 0.5% by weight, and particularly preferably no more than 0.1% by weight.

[0025] According to the present invention, the viscosity of the claimed hair growth agent, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM), is preferably not higher than 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s, to ensure good sprayability.

[0026] Therefore, the preferred subject is the hair growth agent claimed as described above, the viscosity of which, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM), is not higher than 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s.

[0027] The aqueous formulation contains a certain amount of water. Formulations containing 50 to 99% by weight, particularly preferably 65 to 95% by weight, and especially preferably 70 to 90% by weight of water are preferred. The water is primarily used to adjust the concentration of the previously defined ingredients to a range suitable for an aqueous sprayable hair conditioner.

[0028] The claimed hair care product may contain one or more excipients. These optionally present excipients can further stabilize the hair care product having a very low ethanol content. Therefore, preferred subject matter is a hair care product containing at least one excipient from: glycol, polyethylene glycol, glycol ether, glycerin, polyglycerol derivative, amine oxide, betaine, amino alcohol and lactate, or mixtures thereof. Preferred subject matter is also a hair care product as described above, which contains no more than 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight of ethanol and at least one excipient from: glycol, polyethylene glycol, glycol ether, glycerin, polyglycerol derivative, amine oxide, betaine, amino alcohol and lactate, or mixtures thereof.

[0029] Hair care products containing such excipients preferably contain 0.5 to 35% by weight, preferably no more than 25% by weight, and particularly no more than 15% by weight of these excipients.

[0030] Therefore, the preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; less than 18% by weight, preferably not more than 5% by weight, particularly preferably less than 1% by weight, and especially preferably less than 0.5% by weight of ethanol; a buffer system for stabilizing the pH; and at least one excipient selected from glycols, polyethylene glycols, glycol ethers, glycerol, polyglycerol derivatives, amine oxides, betaine, amino alcohols and lactates, or mixtures thereof, preferably in an amount of 0.5 to 25% by weight, particularly preferably not more than 15% by weight, and especially not more than 10% by weight.

[0031] Therefore, the preferred subject matter is a claimed hair care product that also contains at least one diol as an optional excipient. The diol may preferably be ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,2-pentanediol, or dipropylene glycol, or mixtures thereof. If at least one diol is used as an excipient, the diol or mixture of diols is preferably included in the claimed product in a total amount of 0.5 to 20% by weight. The diol is particularly preferred to be 1,2-propanediol and / or 1,2-pentanediol. If 1,2-propanediol is used as an excipient, it is preferably included in the claimed product in an amount of 2 to 20% by weight, particularly preferably 3 to 15% by weight. If 1,2-pentanediol is used as an excipient, it is preferably included in the claimed product in an amount of 0.5 to 5% by weight, particularly preferably 1 to 3.5% by weight.

[0032] Therefore, the preferred subject is an aqueous sprayable hair conditioner having a pH value of 3.0 to 7.0 at 20°C, comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; ethanol in an amount not more than 5% by weight, preferably less than 1% by weight, and particularly preferably less than 0.5% by weight; a buffer system for stabilizing the pH value; and 1,2-propanediol, preferably in an amount of 2 to 20% by weight, and particularly preferably 3 to 15% by weight.

[0033] Therefore, a further preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight of urea and / or 2-hydroxyethylurea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight of adenosine; not more than 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight of ethanol; a buffer system for stabilizing the pH; and 1,2-propanediol, preferably 2 to 20% by weight, particularly preferably 3 to 15% by weight.

[0034] A particularly preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; a buffer system for stabilizing the pH; and 1,2-propanediol, preferably in an amount of 3 to 15% by weight.

[0035] Another particularly preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; 1,2-propanediol, preferably 3 to 15% by weight; and a buffer system for stabilizing the pH, wherein the buffer system is a lactate / sodium lactate buffer or a citrate / disodium hydrogen phosphate buffer, which stabilizes the pH of the product and preferably maintains the pH in the range of 4.0 to 6.0.

[0036] Therefore, the preferred subject is also an aqueous sprayable hair conditioner having a pH value of 3.0 to 7.0 at 20°C, comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; ethanol in an amount not more than 5% by weight, preferably less than 1% by weight, and particularly preferably less than 0.5% by weight; a buffer system for stabilizing the pH value; and 1,2-pentanediol, preferably in an amount of 0.5 to 5% by weight, and particularly preferably 1 to 3.5% by weight.

[0037] Therefore, a further preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 1.0 to 1 wt%, preferably 2.0 to 7.0 wt%, particularly 2.0 to 5.0 wt% of urea and / or 2-hydroxyethylurea; 0.05 to 3 wt%, preferably 0.1 to 2 wt%, particularly preferably 0.2 to 1.5 wt%, particularly 0.5 to 1.0 wt% of adenosine; not more than 5 wt%, preferably less than 1 wt%, particularly preferably less than 0.5 wt% of ethanol; a buffer system for stabilizing the pH; and 1,2-pentanediol, preferably 0.5 to 5 wt%, particularly preferably 1 to 3.5 wt%.

[0038] A particularly preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; a buffer system for stabilizing the pH; and 1,2-pentanediol, preferably in an amount of 1 to 3.5% by weight.

[0039] Another particularly preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; 1,2-pentanediol, preferably 1 to 3.5% by weight; and a buffer system for stabilizing the pH, wherein the buffer system is a lactate / sodium lactate buffer or a citrate / disodium hydrogen phosphate buffer, which stabilizes the pH of the product and preferably maintains the pH in the range of 4.0 to 6.0.

[0040] Therefore, another preferred subject is a hair care agent that also comprises at least one polyethylene glycol as an optional excipient. The polyethylene glycol may preferably be derived from the formula HO-[CH2CH2O]. xOne or more compounds belonging to the group -H, wherein x is an integer from 2 to 100, preferably 2 to 80, more preferably 2 to 60, and even more preferably 3 to 40 or 4 to 20. If polyethylene glycol is used as an optional excipient, the polyethylene glycol or a mixture of polyethylene glycols is preferably included in the claimed product in a total amount of 0.5 to 15% by weight. The polyethylene glycol to be used is particularly preferred to be a polyethylene glycol in which x is an integer from 3 to 40. If such a polyethylene glycol is used, it is preferably included in the claimed product in an amount of 0.5 to 15% by weight, particularly preferably 5.0 to 10% by weight.

[0041] A mixture of the optional excipients described above may also be used as an optional excipient. If optional excipients are used, a further preferred approach is to use a combination of 1,2-propanediol and PEG-40 (i.e., polyethylene glycol according to the formula given above (where x = 40) (INCI: PEG-40 hydrogenated castor oil)). It is then particularly preferred that the amount of 1,2-propanediol is 1.0 to 15% by weight, and the amount of PEG-40 is 0.3 to 5.0% by weight.

[0042] Therefore, another preferred subject is a claimed hair care product that also contains at least one glycol ether as an optional excipient. The glycol ether may preferably be one or more compounds from the group consisting of monomethyl ether, monoethyl ether, and monopropyl ether, and mixtures thereof. If a glycol ether is used as an optional excipient, it is preferably included in the claimed product in a total amount of 0.5 to 15% by weight. The optional glycol ether is particularly preferably diethylene glycol monoethyl ether. If such a glycol ether is used, it is preferably included in the claimed product in an amount of 0.5 to 15% by weight, particularly preferably 5.0 to 10% by weight.

[0043] Therefore, another preferred subject is a hair care product that also contains glycerin as an optional excipient. If glycerin is used as an optional excipient, it is preferably included in the claimed product in an amount of 0.5 to 15% by weight, particularly preferably in an amount of 3.0 to 10% by weight.

[0044] Therefore, another preferred subject is a claimed hair care product that also contains at least one polyglycerol derivative as an optional excipient. The polyglycerol derivative can be at least one of the following: polyglycerol-6 octanoate, polyglycerol-4 decanoate, polyglycerol-3 cocoate, polyglycerol-6 ricinoleate, or polyglycerol-3 decanoate / octanoate / succinate, or mixtures thereof, all known under the INCI name. If at least one polyglycerol derivative is used as an optional excipient, it is preferably included in the claimed product in a total amount of 0.3 to 15% by weight, particularly preferably 2 to 10% by weight, and especially 5 to 9% by weight. The optional polyglycerol derivative is particularly preferably a mixture of polyglycerol-6 octanoate and polyglycerol-4 decanoate. If such a mixture is used, it is preferably included in the claimed product in a total amount of 0.1 to 15% by weight, particularly preferably 0.3 to 10% by weight, and especially 0.5 to 9% by weight.

[0045] Therefore, the preferred subject is also an aqueous sprayable hair conditioner having a pH value of 3.0 to 7.0 at 20°C, comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; ethanol in an amount not more than 5% by weight, preferably less than 1% by weight, and particularly preferably less than 0.5% by weight; a buffer system for stabilizing the pH value; and a mixture of polyglycerol-6 octanoate and polyglycerol-4 decanoate, preferably in an amount of 1 to 15% by weight, particularly preferably 2 to 10% by weight, and especially 5 to 9% by weight.

[0046] Therefore, a further preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight of urea and / or 2-hydroxyethyl urea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight of adenosine; not more than 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight of ethanol; a buffer system for stabilizing the pH; and a mixture of polyglycerol-6 octanoate and polyglycerol-4 decanoate, preferably 1 to 15% by weight, particularly preferably 2 to 10% by weight, particularly 5 to 9% by weight.

[0047] A particularly preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; a buffer system for stabilizing the pH; and a mixture of polyglycerol-6 octanoate and polyglycerol-4 decanoate, preferably in total of 5 to 9% by weight.

[0048] Another particularly preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; a mixture of polyglycerol-6 octanoate and polyglycerol-4 decanoate, preferably in total of 5 to 9% by weight; and a buffer system for stabilizing the pH, wherein the buffer system is a lactate / sodium lactate buffer or a citrate / disodium hydrogen phosphate buffer, which stabilizes the pH of the product and preferably maintains the pH in the range of 4.0 to 6.0.

[0049] Alternatively, a mixture of the optional excipients described above may be used as an optional excipient. If an optional excipient is used, a combination of 1,2-propanediol and polyglycerol-6-octanoate is a further preferred option. It is particularly preferred that the amount of 1,2-propanediol is 2.0 to 20% by weight, and the amount of polyglycerol-6-octanoate is 0.3 to 9% by weight.

[0050] Therefore, another preferred subject is a claimed hair care product that also contains at least one amine oxide as an optional excipient. The amine oxide can be at least one selected from the group consisting of (C5-C18 alkyl)dimethylamine oxides or mixtures thereof. The C5-C18 alkyl chain can, for example, be an alkyl chain based on different fatty acids or fatty alcohols (such as myristic acid, cetyl alcohol, hexanoic acid, octanoic acid, capric acid, lauric acid, myristic acid, palmitic acid, heptadecanic acid, stearic acid, linoleic acid, oleic acid, or mixtures thereof). If an amine oxide is used as an optional excipient, it is preferably included in the claimed product in a total amount of 0.2 to 5% by weight. The optional amine oxide is particularly preferably dodecyl dimethylamine oxide (INCI: laurylamine oxide), cocoyl amine oxide, or mixtures thereof. If dodecyl dimethylamine oxide is used, it is preferably included in the claimed product in a total amount of 0.2 to 10% by weight, particularly preferably 0.5 to 5% by weight, and especially 0.5 to 2% by weight.

[0051] Therefore, the preferred subject is also an aqueous sprayable hair conditioner having a pH value of 3.0 to 7.0 at 20°C, comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; ethanol in an amount not more than 5% by weight, preferably less than 1% by weight, and particularly preferably less than 0.5% by weight; a buffer system for stabilizing the pH value; and dodecyl dimethylamine oxide, preferably in an amount of 0.2 to 10% by weight, particularly preferably 0.5 to 5% by weight, and especially 0.5 to 2% by weight.

[0052] Therefore, a further preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight of urea and / or 2-hydroxyethylurea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight of adenosine; not more than 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight of ethanol; a buffer system for stabilizing the pH; and dodecyl dimethylamine oxide, preferably 0.2 to 10% by weight, particularly preferably 0.5 to 5% by weight, particularly 0.5 to 2% by weight.

[0053] A particularly preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; a buffer system for stabilizing the pH; and dodecyl dimethylamine oxide, preferably in a total amount of 0.5 to 2% by weight.

[0054] Another particularly preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight, of ethanol; and dodecyl dimethylamine oxide, preferably in a total amount of 0.5 to 2% by weight; and a buffer system for stabilizing the pH, wherein the buffer system is a lactate / sodium lactate buffer or a citrate / disodium hydrogen phosphate buffer, which stabilizes the pH of the product and preferably maintains the pH in the range of 4.0 to 6.0.

[0055] Therefore, another preferred subject is a hair care product that also contains at least one betaine as an optional excipient. Betaine may preferably be derived from the formula R-CO-NH-(CH2)3-N + (CH3)2-CH2COO - One or more compounds of the group, wherein R represents an alkyl chain having C5 to C21. If betaine is used as an optional excipient, such betaine or a mixture of multiple betaines is preferably included in the claimed product in a total amount of 0.1 to 5% by weight. The optional betaine is particularly preferably cocamidopropyl betaine (INCI: cocamidopropyl betaine), which is a mixture of lauroamide propyl betaine (INCI: lauroamide propyl betaine) (where R represents a saturated and unbranched C11 alkyl chain) and other betaines derived from coconut oil fatty acids having C8 to C18 alkyl chains. If cocamidopropyl betaine is used, it is preferably included in the claimed product in a total amount of 0.1 to 5% by weight, particularly preferably 0.3 to 3% by weight, and especially 0.5 to 2% by weight.

[0056] Therefore, the preferred subject is also an aqueous sprayable hair conditioner having a pH value of 3.0 to 7.0 at 20°C, comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; ethanol in an amount not more than 5% by weight, preferably less than 1% by weight, and particularly preferably less than 0.5% by weight; a buffer system for stabilizing the pH value; and cocamidopropyl betaine, preferably in an amount of 0.1 to 5% by weight, particularly preferably 0.3 to 3% by weight, and especially 0.5 to 2% by weight.

[0057] Therefore, a further preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight of urea and / or 2-hydroxyethylurea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight of adenosine; not more than 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight of ethanol; a buffer system for stabilizing the pH; and cocamidopropyl betaine, preferably 0.1 to 5% by weight, particularly preferably 0.3 to 3% by weight, particularly 0.5 to 2% by weight.

[0058] A particularly preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; a buffer system for stabilizing the pH; and cocamidopropyl betaine, preferably in a total amount of 0.5 to 2% by weight.

[0059] Another particularly preferred subject is an aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; cocamidopropyl betaine, preferably in a total amount of 0.5 to 2% by weight; and a buffer system for stabilizing the pH, wherein the buffer system is a lactate / sodium lactate buffer or a citrate / disodium hydrogen phosphate buffer, which stabilizes the pH of the product and preferably maintains the pH in the range of 4.0 to 6.0.

[0060] For all embodiments in which 2-hydroxyethylurea is used alone or in combination with urea, it is preferred that the composition contains additional excipients. Particularly preferred are the presence of an amino alcohol (preferably 2-aminoethanol) and / or a lactate (preferably ammonium lactate) in embodiments containing 2-hydroxyethylurea or embodiments containing both 2-hydroxyethylurea and urea. In this case, it is particularly preferred that the ratio of 2-hydroxyethylurea to 2-aminoethanol is from 100:1 to 50:1. In this case, it is particularly preferred that the ratio of 2-hydroxyethylurea to ammonium lactate is from 15:1 to 25:1.

[0061] In addition to the excipients mentioned above, the hair care products for which protection is sought may contain other ingredients such as fragrances or perfumes, extracts (especially plant extracts), preservatives, pH adjusters, dyes, other detergent substances, and mixtures thereof.

[0062] Another subject of this application is the use of the claimed product as a hair growth agent.

[0063] The above has already illustrated stable aqueous compositions containing high concentrations of adenosine. Therefore, another subject of this application is the use of urea and / or urea derivatives for stabilizing adenosine in aqueous compositions with an ethanol content of less than 18% by weight. Therefore, another subject of this application is the use of urea and / or urea derivatives and excipients for stabilizing adenosine in aqueous compositions with an ethanol content of no more than 5% by weight, wherein the excipients are selected from glycols, polyethylene glycols, glycol ethers, glycerol, polyglycerol derivatives, amine oxides, betaine, amino alcohols, and lactates, or mixtures thereof.

[0064] Therefore, another subject matter of this application is the use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, particularly the scalp. Thus, another subject matter of this application is the use of a sprayable aqueous formulation containing adenosine, urea and / or urea derivatives, and excipients with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, particularly the scalp, wherein the excipients are selected from glycols, polyethylene glycols, glycol ethers, glycerin, polyglycerol derivatives, amine oxides, betaine, amino alcohols, and lactates, or mixtures thereof.

[0065] All information provided for the product also applies directly to the intended use. This applies in particular, but not exclusively, to data and characteristics of urea (derived products), adenosine, buffer substances and systems, excipients, ethanol content, viscosity, pH value, measurement methods, and other said components.

[0066] The invention is further described, but not exhaustively, by the following entries: Item 1: An aqueous sprayable hair conditioner having a pH of 3.0 to 7.0 at 20°C, comprising a total amount of 1.0 to 20% by weight of urea and / or urea derivatives, an amount of 0.05 to 3% by weight of adenosine, and a buffer system for stabilizing the pH, wherein the hair conditioner contains less than 18% by weight, preferably no more than 10% by weight, and particularly no more than 5% by weight of ethanol.

[0067] Item 2: The product according to Item 1, wherein the buffer system is a lactate / sodium lactate buffer or a citrate / disodium hydrogen phosphate buffer.

[0068] Item 3: The product according to one of the preceding items, wherein the urea derivative is 2-hydroxyethylurea.

[0069] Item 4: A product according to any one of the preceding items, wherein the product comprises at least one excipient from: glycol, polyethylene glycol, glycol ether, glycerol, polyglycerol derivative, amine oxide, betaine, amino alcohol and lactate, or mixtures thereof.

[0070] Item 5: The product according to Item 4, wherein the diol is ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,2-pentanediol, or dipropylene glycol, or a mixture thereof.

[0071] Item 6: The product according to Item 4, wherein the polyethylene glycol is derived from the product according to the formula HO-[CH2CH2O]. x One or more compounds of the group -H, wherein x is an integer from 2 to 100, preferably from 2 to 80, more preferably from 2 to 60, or even more preferably from 3 to 40 or from 4 to 20.

[0072] Item 7: The product according to Item 4, wherein the polyglycerol derivative is at least one of the following: polyglycerol-6 octanoate, polyglycerol-4 decanoate, polyglycerol-3 cocoate, polyglycerol-6 ricinoleate, or polyglycerol-3 decanoate / octanoate / succinate, or a mixture thereof, under the INCI name.

[0073] Item 8: The product according to Item 4, wherein the amine oxide is at least one of (C5-C18 alkyl) dimethylamine oxide, or a mixture thereof.

[0074] Item 9: The product according to Item 9, wherein the betaine is derived from the formula R-CO-NH-(CH2)3-N + (CH3)2-CH2COO - One or more compounds of the group, wherein R is an alkyl chain having C5 to C21.

[0075] Item 10: The product according to Item 4, wherein the amino alcohol is 2-aminoethanol, and / or the lactate is ammonium lactate.

[0076] Item 11: The product according to any one of items 4 to 10, wherein the product contains no more than 5% by weight, preferably less than 1% by weight, of ethanol, and in particular does not contain ethanol.

[0077] Item 12: A product according to any one of the preceding items, wherein the product comprises less than 0.5% by weight of one or more components from the group consisting of adenosine 5'-phosphate.

[0078] Item 13: The product according to any one of the preceding items, wherein the product comprises 0.1 to 2.0% by weight, preferably 0.1 to 1.0% by weight, of adenosine.

[0079] Item 14: The product according to any one of the preceding items, wherein the total amount of said urea and / or urea derivative is 1.0 to 15% by weight, preferably 2.0 to 7.0% by weight, more preferably 2.0 to 5.0% by weight.

[0080] Item 15: A product according to any one of items 4 to 14, wherein one or more excipients are present in a total amount of 0.5 to 35% by weight, preferably in an amount of no more than 25% by weight.

[0081] Item 16: The product according to any one of the preceding items, wherein the viscosity of the product, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM), is not higher than 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s.

[0082] Item 17: The product according to any one of the preceding items, wherein the product has a pH value of 3.0 to 7.0, preferably 4.0 to 6.0, and particularly 4.2 to 5.5 at 20°C.

[0083] Item 18: Use of urea and / or urea derivatives for stabilizing adenosine in aqueous compositions containing less than 18% by weight of ethanol.

[0084] Item 19: Use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, especially the scalp.

[0085] Exemplary implementation scheme: The following compositions are prepared as follows: Dissolve adenosine in water at 50°C. Add sodium benzoate to the 50°C solution and dissolve. Add and dissolve all other components except urea and / or urea derivatives and buffer substances. Then add the buffer substances as an aqueous solution. Then cool the solution to below 25°C. Add urea and / or urea derivatives to the solution at a temperature of 20 to 25°C and dissolve.

[0086] 1 INCI: Polyglycerol-6-octanoate (and) polyglycerol-4-decanoate The resulting compositions were stored at room temperature (20°C) and at 40°C. The pH values ​​of the compositions were measured immediately after preparation and after storage. All compositions were shown to be stable at room temperature for at least 3 weeks. When stored at 40°C for 3 weeks, a significant increase in pH values ​​was observed in compositions V1 and V2, indicating decomposition. Compositions E1a-c and E2a-c were stable even at 40°C for at least this period; the pH values ​​increased only slightly.

Claims

1. An aqueous sprayable hair conditioner, said aqueous sprayable hair conditioner having a pH value of 3.0 to 7.0 at 20°C, comprising 1.0 to 20% by weight of urea and / or urea derivatives, 0.05 to 3% by weight of adenosine, and a buffer system for stabilizing the pH value, characterized in that, The hair growth agent contains less than 18% by weight, preferably no more than 10% by weight, and particularly no more than 5% by weight of ethanol.

2. The product according to claim 1, wherein the buffer system is a lactate / sodium lactate buffer or a citrate / disodium hydrogen phosphate buffer.

3. The product according to any one of the preceding claims, wherein the urea derivative is 2-hydroxyethylurea, and / or the total amount of the urea and / or urea derivative is 1.0 to 15% by weight, preferably 2.0 to 7.0% by weight, more preferably 2.0 to 5.0% by weight.

4. The product according to any one of the preceding claims, wherein the product comprises at least one excipient from: glycol, polyethylene glycol, glycol ether, glycerol, polyglycerol derivative, amine oxide, betaine, amino alcohol and lactate, or mixtures thereof.

5. The product according to claim 4, wherein the diol is ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,2-pentanediol, or dipropylene glycol, or a mixture thereof.

6. The product according to claim 4, wherein the polyglycerol derivative is at least one of polyglycerol derivatives known by the INCI names polyglycerol-6 caprylate, polyglycerol-4 decanoate, polyglycerol-3 cocoate, polyglycerol-6 ricinoleate, or polyglycerol-3 decanoate / caprylate / succinate, or mixtures thereof.

7. The product according to any one of claims 4 to 6, wherein the product contains no more than 5% by weight, preferably less than 1% by weight, of ethanol, and in particular, does not contain ethanol.

8. The product according to any one of the preceding claims, wherein the product comprises 0.1 to 2.0% by weight, preferably 0.1 to 1.0% by weight, of adenosine.

9. The product according to any one of the preceding claims, wherein the viscosity of the product, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM), is not higher than 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s.

10. A sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight, for use in cosmetic treatment of the skin, especially the scalp.

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