A method for mass production of "I" shaped test paper strip for sanitary products

Abstract

This invention relates to a method for the large-scale production of "I"-shaped test strips for hygiene products, belonging to the field of medical test strip processing. The "I"-shaped test strip is an improvement and breakthrough of conventional test strips, reducing the foreign body sensation and other discomfort caused to users when used in hygiene products without affecting the test strip's detection function. The large-scale production process includes cutting colloidal gold-nitrocellulose boards, attaching colloidal gold-nitrocellulose strips to a substrate, attaching sample pads and absorbent pads to the substrate, laminating a top waterproof membrane, and rolling the formed test strips. This process can continuously produce high-quality "I"-shaped test strip rolls, meeting the diverse production needs of the hygiene product industry.

Description

Technical Field

[0001] This invention belongs to the field of medical test strip processing, and mainly relates to a method for large-scale production of "I"-shaped test strips for hygiene products.

[0002] Background Area

[0003] With the diversification of medical test strips, the application scenarios of test strips are gradually expanding. Currently, some companies have proposed to apply traditional medical test strips to hygiene products, giving hygiene products the performance of medical testing.

[0004] Currently, although the preparation and production of traditional test strips are relatively mature, due to the materials and structural design, traditional test strips have the following four disadvantages when applied to hygiene products: First, the thicker sample collection area and sample absorption area can cause a strong foreign body sensation when worn by users, greatly affecting the user experience; second, the small sample collection area of ​​traditional test strips leads to insufficient collection efficiency of the biological liquid to be tested, causing test failure; third, the narrow overall width of traditional test strips (usually 3mm) greatly increases the integration process of the test strips in hygiene products; finally, since traditional test strips are not waterproofed, the biological liquid to be tested can easily come into direct contact with the nitrocellulose (NC) membrane and absorbent pad, causing the test strip to fail.

[0005] Based on this, we redesigned and prepared an "I"-shaped test strip, which is mainly used in hygiene products. For details, please refer to (CN119044479A).

[0006] In the early stages of experimentation, there were several problems with the production of the "I"-shaped test strips: manual cutting and pasting were required, resulting in low production efficiency, poor product quality control, and difficulty in directly installing individual products into hygiene product production lines. Summary of the Invention

[0007] In response to the problems existing in the aforementioned fields, this invention mainly introduces the large-scale production of "I"-shaped test strips to meet the extensive production needs of this type of test strip in the field of hygiene products.

[0008] This invention solves the above-mentioned technical problems through the following technical means: a method for large-scale production of "I"-shaped test strips for hygiene products, described according to the process flow direction, involves sequentially fixing the top and bottom biaxially oriented polyester (BOPP) rolls onto rotating rollers; fixing the absorbent pad and sample pad onto rotating rollers parallel to the above; cutting colloidal gold-NC film sheets into strips of equal length, and using mechanical suction cups to place the colloidal gold-NC film strips at equal intervals on the bottom BOPP film; placing the sample pad and absorbent pad on opposite sides, close to and away from the colloidal gold, respectively; covering the surface of the above product with a layer of BOPP film to ensure the sample pad is exposed; and finally, rolling the formed sample strips.

[0009] This invention has the following outstanding technical advantages:

[0010] The "I"-shaped test strip, through optimized material and structural design, significantly reduces the foreign body sensation during use in hygiene products compared to traditional test strips, while ensuring accurate and efficient detection. The "I"-shaped test strip rolls, mass-produced based on this technology, can increase the sampling area and sample absorption efficiency, meeting market demands for large-volume use in hygiene products. Furthermore, the continuously produced "I"-shaped test strip rolls meet the installation requirements of hygiene product production lines. Detailed Implementation

[0011] The present invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific examples are only used to explain and introduce the present invention and cannot limit the scope of application of the present invention. Any modifications and changes made to the present invention without departing from the purpose and scope of the present invention shall fall within the protection scope of the present invention.

[0012] In order to explore the large-scale continuous production process of efficient and high-quality "I"-shaped test strips, the important influencing factor of the distance between the upper and lower pressure rollers after the top layer is coated was investigated, as described in the following examples:

[0013] In a specific embodiment, the width of the colloidal gold-NC film strip is 2.5-3.5 mm, the length is 22.5-24.5 mm, and the thickness is 0.3 mm.

[0014] In a specific implementation, the mechanical suction cup can pick up 5-7 colloidal gold-NC film strips at a time.

[0015] In a specific implementation, the spacing between the colloidal gold-NC strips is 5-20 mm.

[0016] In a specific implementation, the mechanical suction cup grips at intervals of 6 seconds per grip.

[0017] In a specific embodiment, the material of the sample pad is a polyester fiber film. The width of the sample pad is 6.5 - 7.5 mm, and the thickness is 0.1 - 0.3 mm.

[0018] In a specific embodiment, both the bottom layer and the top layer are biaxially oriented polyester BOPP films. The width of the bottom BOPP film is 39.5 - 40.5 mm, and the width of the top BOPP film is 32 - 34 mm. They have the same thickness, which is 0.05 - 0.3 mm.

[0019] In a specific embodiment, the sample pad is placed close to the colloidal gold side and aligned with the outer side 1 of the BOPP substrate.

[0020] In a specific embodiment, the material of the absorption pad is plant fiber. The plant fiber is composed of a ratio of long filaments and short fibers. The proportion of long filaments is 10 - 50%, and the gram weight is 20 - 100 g / m 2 .

[0021] In a specific embodiment, the width of the absorption pad is 12.5 - 13.5 mm, and the thickness is 0.1 - 0.3 mm.

[0022] In a specific embodiment, the absorption pad is placed far from the colloidal gold side and aligned with the outer side 2 of the BOPP substrate.

[0023] In a specific embodiment, the top BOPP film overlaps and composites along the outer side 2 of the bottom BOPP film.

[0024] In a specific embodiment, the distance between the top BOPP film and the pressure roller of the bottom material is 0.1 - 0.3 mm.

[0025] In a specific embodiment, the width of the "I"-shaped test strip roll is 39.5 - 40.5 mm, the maximum thickness is 0.5 mm, and the minimum thickness is 0.2 mm.

[0026] In a specific embodiment, the rotational speed of the winding machine is 50 - 55 m / h. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] The above content of the present invention and the following specific embodiments will be better understood when read in conjunction with the accompanying drawings. It should be noted that the drawings are only examples of the claimed technical solutions.

[0028] Figure 1 is a schematic diagram of the mass production process of the "I"-shaped test strip.

[0029] Figure 2 is a schematic diagram of cutting the colloidal gold - NC membrane sheet into equal - width strips.

[0030] Figure 3 is a schematic diagram of the BOPP substrate.

[0031] Figure 4 This is a schematic diagram of the sample pad.

[0032] Figure 5 This is a schematic diagram of an absorbent pad.

[0033] Figure 6 This is a schematic diagram of the top BOPP surface layer.

[0034] Figure 7 This is a schematic diagram of an "I"-shaped test strip produced continuously.

[0035] Example 1:

[0036] This method involves a large-scale production process for "I"-shaped test strips used in hygiene products, illustrated in the following diagram. Figure 1 As shown. The specific implementation steps are as follows:

[0037] Step 1: In this invention, the colloidal gold-NC film sheet is first cut into strips of equal length using a cutting machine. The strips are 23.5 mm long, 3 mm wide, and 0.3 mm thick. The cutting process is as follows: Figure 2 As shown.

[0038] Step 2: Using a mechanical suction cup, pick up six colloidal gold-NC film strips and place them on a BOPP substrate. Each colloidal gold-NC film strip is spaced 10mm apart. The BOPP substrate thickness is 0.05mm. After placing the colloidal gold-NC strips on the BOPP substrate... Figure 3 As shown.

[0039] Step 3: Use a roller to cover the sample pad near the colloidal gold side, and... Figure 3 As shown in Figure 1, the sample pad is aligned at the specified position. The sample pad is 7 mm wide and 0.1 mm thick. The shape of the sample pad is as follows: Figure 4 As shown.

[0040] Step 4: Use the rotating roller to cover the absorbent pad on the side away from the colloidal gold, and... Figure 3 The positions shown in Figure 2 are aligned, and the ratio of long filament to short fiber in the absorbent pad is 1:9, with a basis weight of 40g / m². 2 It is 13mm wide and 0.1mm thick, and the absorbent pad is shaped like... Figure 5 As shown.

[0041] Step 5: Using pressure rollers, coat the surface of the material prepared in Steps 3 and 4 with a layer of BOPP film. This film is 30 mm wide and 0.05 mm thick, with the pressure rollers spaced 0.1 mm apart. The top BOPP film shape is as follows: Figure 6 As shown.

[0042] Step Six: Stretch and roll the "I"-shaped test strip prepared in Step Five. The test strip should be 40mm wide, with a maximum thickness of 0.5mm and a minimum thickness of 0.2mm. The rolling speed should be 52m / h. The prepared test strip should look like this. Figure 7 As shown.

[0043] Example 2:

[0044] This method involves a large-scale production process for "I"-shaped test strips used in hygiene products, illustrated in the following diagram. Figure 1 As shown. The specific implementation steps are as follows:

[0045] Step 1: In this invention, the colloidal gold-NC film sheet is first cut into strips of equal length using a cutting machine. The strips are 23.5 mm long, 3 mm wide, and 0.3 mm thick. The cutting process is as follows: Figure 2 As shown.

[0046] Step 2: Using a mechanical suction cup, pick up six colloidal gold-NC film strips and place them on a BOPP substrate. Each colloidal gold-NC film strip is spaced 10mm apart. The BOPP substrate thickness is 0.05mm. After placing the colloidal gold-NC strips on the BOPP substrate... Figure 3 As shown.

[0047] Step 3: Use a roller to cover the sample pad near the colloidal gold side, and... Figure 3 As shown in Figure 1, the sample pad is aligned at the specified position. The sample pad is 7 mm wide and 0.1 mm thick. The shape of the sample pad is as follows: Figure 4 As shown.

[0048] Step 4: Use the rotating roller to cover the absorbent pad on the side away from the colloidal gold, and... Figure 3 The positions shown in Figure 2 are aligned, and the ratio of long filament to short fiber in the absorbent pad is 1:9, with a basis weight of 40g / m². 2 It is 13mm wide and 0.1mm thick, and the absorbent pad is shaped like... Figure 5 As shown.

[0049] Step 5: Using pressure rollers, cover the surface of the material prepared in Steps 3 and 4 with a layer of BOPP film. The film is 30mm wide and 0.05mm thick, and the pressure rollers are spaced 0.2mm apart. The top BOPP film has the following shape: Figure 6 As shown.

[0050] Step Six: Stretch and roll the "I"-shaped test strip prepared in Step Five. The test strip should be 40mm wide, with a maximum thickness of 0.5mm and a minimum thickness of 0.2mm. The rolling speed should be 52m / h. The finished test strip should look like this. Figure 7 As shown.

[0051] Example 3:

[0052] This method involves a large-scale production process for "I"-shaped test strips used in hygiene products, illustrated in the following diagram. Figure 1 As shown. The specific implementation steps are as follows:

[0053] Step 1: In this invention, the colloidal gold-NC film sheet is first cut into strips of equal length using a cutting machine. The strips are 23.5 mm long, 3 mm wide, and 0.3 mm thick. The cutting process is as follows: Figure 2 As shown.

[0054] Step 2: Using a mechanical suction cup, pick up six colloidal gold-NC film strips and place them on a BOPP substrate. Each colloidal gold-NC film strip is spaced 10mm apart. The BOPP substrate thickness is 0.05mm. After placing the colloidal gold-NC strips on the BOPP substrate... Figure 3 As shown.

[0055] Step 3: Use a roller to cover the sample pad near the colloidal gold side, and... Figure 3 As shown in Figure 1, the sample pad is aligned at the specified position. The sample pad is 7 mm wide and 0.1 mm thick. The shape of the sample pad is as follows: Figure 4 As shown.

[0056] Step 4: Use the rotating roller to cover the absorbent pad on the side away from the colloidal gold, and... Figure 3 The positions shown in Figure 2 are aligned, and the ratio of long filament to short fiber in the absorbent pad is 1:9, with a basis weight of 40g / m². 2 It is 13mm wide and 0.1mm thick, and the absorbent pad is shaped like... Figure 5 As shown.

[0057] Step 5: Using pressure rollers, coat the surface of the material prepared in Steps 3 and 4 with a layer of BOPP film. This film is 30mm wide and 0.05mm thick, with the pressure rollers spaced 0.3mm apart. The top BOPP film has the following shape: Figure 6 As shown.

[0058] Step Six: Stretch and roll the "I"-shaped test strip prepared in Step Five. The test strip should be 40mm wide, with a maximum thickness of 0.5mm and a minimum thickness of 0.2mm. The rolling speed should be 52m / h. The prepared test strip should look like this. Figure 7 As shown.

[0059] Analysis and Discussion

[0060] For each of the above embodiments, 30 samples were taken at equal intervals. Equal amounts of the test liquid were taken and tested using the samples from the above embodiments. The test results are shown in Table 1. The results were considered valid if the test line and control line appeared within 10 minutes.

[0061] Table 1. Statistics of test results in the embodiments.

[0062]

[0063] In Example 1, after the sample to be tested contacted the sample pad, the detection line and control line took a long time to appear, and the traces were shallow. This was because the gap between the upper and lower pressure rollers was large, and the top coating did not fully adhere to other materials. After the test liquid soaked in, it flowed outwards, resulting in less lateral flow of test liquid and a lag in the appearance of the test results. Subsequently, using Example 1, two additional samples of the test liquid were tested (not included in the statistics in the table above), and the detection effect was significantly improved.

[0064] In Example 2, after the sample to be tested came into contact with the sample pad, the test liquid flowed rapidly, and the detection line and control line appeared within a short time.

[0065] In Example 3, after the sample to be tested came into contact with the sample pad, the test liquid flowed unevenly on the NC membrane, and the detection line and control line were also incomplete. This was because the gap between the upper and lower pressure rollers was small, which caused a certain degree of damage to the NC membrane during the coating process, resulting in obstruction of liquid flow.

[0066] In summary, Example 2 is the optimal production solution.

Claims

1. A method for large-scale production of "I"-shaped test strips for hygiene products, characterized by including: The following steps: (1) Use a cutting machine to cut the colloidal gold-NC membrane sheet into strips of equal length. (2) Use a mechanical suction cup to grasp the colloidal gold-NC membrane strip and place it on a BOPP substrate with single-sided adhesive. (3) Use a roller to cover the sample pad on the side close to the colloidal gold. (4) Use a roller to cover the absorbent pad on the side far from the colloidal gold. (5) Use a pressure roller to cover a layer of BOPP film with single-sided adhesive on the surface of the material prepared in the above steps. (6) Stretch and wind the "I"-shaped test strip prepared in step (5).

2. The preparation method according to claim 1, characterized in that, In the said step (1), the length of the colloidal gold-NC membrane strip is 22.5 - 24.5 mm, the width is 2.5 - 3.5 mm, and the thickness is 0.3 mm.

3. The preparation method according to claim 1, characterized in that, In the said step (2), the number of colloidal gold-NC membrane strips grasped by the mechanical suction cup at one time is 5 - 7, the grasping interval is 6 s / time, and the interval for placing the colloidal gold-NC membrane strip is 5 - 20 mm.

4. The preparation method according to claim 1, characterized in that, In the said step (2), the width of the bottom BOPP film is 39.5 - 40.5 mm, and the thickness is 0.05 mm.

5. The preparation method according to claim 1, characterized in that, In the said step (3), the material of the sample pad is polyester fiber, the width of the sample pad is 6.5 - 7.5 mm, and the thickness is 0.1 mm.

6. The preparation method according to claim 1, characterized in that, In step (4), the absorbent pad is made of plant fiber, which is composed of filaments and staple fibers, with filaments accounting for 10-50% and a basis weight of 20-100 g / m². 2 The absorbent pad has a width of 12.5-13.5mm and a thickness of 0.1mm.

7. The preparation method according to claim 1, characterized in that, In the said step (5), the width of the surface BOPP film is 32 - 34 mm, and the thickness is 0.05 mm.

8. The preparation method according to claim 1, characterized in that, In the said step (5), the distance between the pressure roller of the surface BOPP film and the bottom material is 0.1 - 0.3 mm.

9. The preparation method according to claim 1, characterized in that, In the said step (6), the width of the "I"-shaped test strip roll is 39.5 - 40.5 mm, the maximum thickness is 0.5 mm, and the minimum thickness is 0.2 mm.

10. The preparation method according to claim 1, characterized in that, In the said step (6), the rotation speed of the winding machine is 50 - 55 m / h.

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