A kind of detection whole blood reagent card shell

Abstract

This utility model relates to the field of reagent cartridge technology, and provides a whole blood testing reagent cartridge, including an upper cover with a first recess, a second recess, and a second raised strip. The bottom of the first recess has an elliptical sample application hole, and the back side of the sample application hole corresponds to the blood filtration membrane of the reagent cartridge. The second recess corresponds to the nitrocellulose membrane. The second raised strip is located on the back side of the upper cover and is perpendicular to the direction of the guide groove. The second raised strip is disposed between the conjugate pad and the nitrocellulose membrane. The lower shell includes a first concave locking strip and a second locking strip disposed at the bottom of the lower shell. The side wall of the first concave locking strip is provided with several protrusions. The first concave locking strip and the second locking strip, together with the upper cover, form a box structure. One end of the reagent cartridge uses a locking design to prevent vertical movement, and the other end is surrounded to prevent horizontal movement.

Description

Technical Field

[0001] This utility model relates to the field of reagent cartridge technology, specifically to a reagent cartridge for testing whole blood. Background Technology

[0002] The reagent cartridge is a plastic card used in the immunochromatographic reagent process. The card contains a test component consisting of an NC membrane, absorbent paper, conjugate pad, buffer pad, and blood filtration membrane. Figure 1 As shown, the reagent cartridge, which houses these components, forms the reagent test card. A circular sample dispensing hole is provided on the cartridge. When in use, blood is dripped into the circular sample dispensing hole to prepare the sample.

[0003] However, the inventors discovered that existing reagent test cards are square cards. In order to ensure that the reagent test card is placed stably inside the reagent card case, a pair of square baffles are generally set inside the reagent card case along the length of the reagent card case. The reagent test card is placed inside the baffles. When testing is required, the reagent test card is placed in the detector. When the detector is running, the test card will shift in the baffles, affecting the test results. Utility Model Content

[0004] The purpose of this invention is to provide a whole blood test reagent cartridge that can solve the technical problem of poor stability of existing test card installation structures.

[0005] To achieve the above objectives, a whole blood testing reagent cartridge includes a top cover. The top cover is provided with a first recess, a second recess, and a second raised strip. An elliptical sample application hole is provided at the bottom of the first recess, and the back side of the sample application hole is provided corresponding to the blood filtration membrane of the reagent cartridge. The second recess is provided corresponding to the nitrocellulose membrane. The second raised strip is located on the back side of the top cover and is provided perpendicular to the direction of the guide groove. The second raised strip is provided between the conjugate pad and the nitrocellulose membrane. A first stepped groove is provided on the side of the top cover.

[0006] The lower shell includes a first concave retaining strip and a second retaining strip disposed at the bottom of the lower shell. The side wall of the first concave retaining strip is provided with several protrusions. The first concave retaining strip and the second retaining strip, together with the upper cover, form a box structure. A second stepped groove is opened on the side of the lower shell corresponding to the first stepped groove.

[0007] Further configuration: a cylindrical protrusion is provided at the end of the top cover away from the first recess, and two parallel first protrusion strips are provided on the top cover.

[0008] Further configured, the first protrusion is arranged along the direction of the guide groove, and the spacing between the two first protrusions is greater than the width of the guide groove.

[0009] Further, the inner side of the lower shell is provided with a first concave retaining strip and a second concave retaining strip.

[0010] Further configured, the first concave locking strip engages with the first protruding strip, with the open end of the first concave locking strip abutting against one end of the first recess.

[0011] Further configured, the second concave locking strip engages with the first protruding strip, with the open end of the second concave locking strip abutting against one end of the second recess.

[0012] Further configured such that the open ends of the first concave card strip and the second concave card strip are positioned opposite each other.

[0013] Further configured, the first recess is conical.

[0014] Further, a groove is provided on one side of the first recess.

[0015] A further configuration is that the groove is provided with a plurality of circular holes.

[0016] The beneficial effects of one or more of the above technical solutions:

[0017] The reagent card is better held in place by the first protruding strip on the upper cover and the first concave locking strip on the lower shell. The structure of the entire card case is relatively stable and not easy to detach. At the same time, a second locking strip is used on one end of the reagent card to prevent it from moving up and down, and a first concave locking strip is set on the other end. The first concave locking strip prevents the reagent card from moving left and right by protrusions, which increases the stability of the reagent card installation. Attached Figure Description

[0018] The accompanying drawings, which form part of this application, are used to provide a further understanding of this application. The illustrative embodiments of this application and their descriptions are used to explain this application and do not constitute a limitation thereof.

[0019] Figure 1 This is a structural diagram of the test piece;

[0020] Figure 2 This is a structural diagram of the present invention;

[0021] Figure 3 This is a structural diagram of the top cover of this utility model;

[0022] Figure 4 This is a structural diagram of the lower shell of this utility model.

[0023] In the diagram, 1 is the top cover, 2 is the bottom shell, 3 is the sample inlet, 4 is the flow channel, 5 is the first raised strip, 6 is the first concave retaining strip, 7 is the second retaining strip, 8 is the groove, and 9 is the second recess.

[0024] 10. Blood filtration membrane, 11. Buffer pad, 12. Conjunction pad, 13. NC membrane, 14. Absorbent paper, 15. PVC base plate, 16. Cylindrical protrusion, 17. Second protrusion strip, 18. First pit, 19. Concave ridge, 20. First stepped groove, 21. Second stepped groove, 22. Groove, 23. Round hole. Detailed Implementation

[0025] The specific implementation of this embodiment will now be described with reference to the accompanying drawings.

[0026] like Figure 1 The diagram shows the structure of an existing reagent card. From left to right, the reagent card consists of a blood filtration membrane 10, a buffer pad 11, a conjugate pad 12, an NC membrane (nitrocellulose membrane) 13, and absorbent paper 14. A PVC base plate 15 is placed at the bottom. The blood filtration membrane 10, buffer pad 11, conjugate pad 12, NC membrane 13, and absorbent paper 14 are placed on top of the PVC base plate. The blood filtration membrane 10, buffer pad 11, and conjugate pad 12 are partially overlapped, and the NC membrane 13 and absorbent paper 14 are partially overlapped. The conjugate pad 12 and absorbent paper 14 work together to press down the NC membrane.

[0027] The existing method of using reagent cards involves placing the card into a reagent card holder to prevent contamination and to withstand external stress. The fluorescence immunoassay analyzer is used for reagent incubation and detection. After the reagent card is inserted into the holder, a blood sample is added through the sample application port 3. The holder is then placed into the analyzer, where it rotates to position the holder corresponding to the reagent. The reagent is then manually added to the second recess 9 of the holder. This process is repeated until the reagent card is rotated to the detection position, where fluorescence detection is performed to obtain the result. The holder is then ejected.

[0028] Therefore, the chuck will rotate during this process, so the entire chuck structure needs to be stable. The blood sample moves from the sample application port 3 to the position of the second recess. Therefore, the present invention designs an open flow channel 4 to fully guide the flow to the position of the NC membrane corresponding to the second recess, thereby reducing damage.

[0029] This utility model relates to a whole blood testing reagent cartridge, comprising: a top cover 1, having a first recess 18, a second recess 9, and a second raised strip 17; an elliptical sample application hole 3 is provided at the bottom of the first recess 18, the back side of the sample application hole 3 corresponding to the position of the blood filtration membrane of the reagent cartridge; the second recess 9 corresponding to the position of the nitrocellulose membrane; the second raised strip 17 is located on the back side of the top cover, the second raised strip 17 is arranged perpendicular to the direction of the flow guide groove 4, and the second raised strip 17 corresponds to the position between the conjugate pad and the NC membrane; the flow guide groove 4 is provided on the back side of the top cover 1 along the direction of the sample application hole 3, the flow guide groove 4 covering the position of the sample application hole 3, enabling sample flow guidance. The reagent card is positioned on the nitrocellulose membrane. One end of the lower shell 2 uses a second locking strip 7 to prevent the reagent card from moving up and down, and the other end is provided with a first concave locking strip 6. The first concave locking strip 6 prevents the reagent card from moving left and right through protrusions. The lower shell 2 and the upper cover 1 cooperate to form a box structure. A first stepped groove is opened on the side of the upper cover, and a second stepped groove is opened on the side of the lower shell corresponding to the first stepped groove. After the first and second stepped grooves are engaged, they prevent the lower shell from shaking and prevent the dripped liquid from seeping into both sides of the blood filtration membrane. At the same time, they facilitate the engagement of the upper cover and the lower shell, ensure that the pressure is in place during assembly, and improve stability.

[0030] The reagent cartridges used in testing typically involve dropping the sample into the sample application well 3, which then comes into contact with the blood filtration membrane inside the cartridge. However, existing circular sample application wells have insufficient contact area between the sample and the filtration membrane, leading to inadequate blood filtration. This invention features an elliptical sample application well, increasing the contact area with the filtration membrane.

[0031] Furthermore, the oval sample application well 3 and the flow guide groove 4 on the back side work together. The flow guide groove is oriented in the same direction as the rectangle, and the sample application well is located in the middle area of ​​the flow guide groove. There is space between the flow guide groove and the blood filtration membrane. After the sample is added, it will expand on the blood filtration membrane under the guidance of the flow guide groove, which helps to increase the contact area between the sample and the blood filtration membrane. This facilitates the flow of the sample from the blood filtration membrane to the NC membrane, making the flow smoother. It also increases the space between the top cover and the reagent card, reducing the damage to red blood cells. This results in more accurate detection after the sample flows to the NC membrane.

[0032] The upper cover is provided with a second raised strip 17, which is perpendicular to the direction of the guide groove 4 and corresponds to the position between the bonding pad and the NC membrane. Figure 1 The position between the conjugate pad and the NC membrane is shown. Because the sample liquid flows into the NC membrane through the conjugate pad, the second protrusion 17 serves to prevent the liquid from flowing directly through, allowing the liquid to enter the NC membrane after passing through the conjugate pad, which is beneficial for sample testing.

[0033] The short side of the elliptical sample well 3 is arc-shaped. This arc-shaped structure serves to buffer the sample and facilitate flow.

[0034] The top cover is provided with two parallel first protrusions 5, which are arranged along the direction of the guide groove 4. The distance between the two first protrusions is greater than the width of the guide groove 4. The two first protrusions 5 cooperate with the concave retaining strip described below, and also serve as a limiting function.

[0035] A cylindrical protrusion 16 is provided at the end of the upper cover 1 furthest from the first recess. Furthermore, the number of cylindrical protrusions 16 is set to one to four. The cylindrical protrusion 16 is provided at the end furthest from the first recess, corresponding to... Figure 1 The position of the absorbent paper is used to hold the absorbent paper in place, thus positioning the reagent card.

[0036] It also includes a lower shell 2, which, together with the upper cover 1, forms a box structure. The upper cover 1 and the lower shell 2 combine to form a housing structure, inside which test pieces are placed for easy testing and transfer.

[0037] The inner side of the lower shell 2 is provided with a raised first concave retaining strip 6, which engages with the first raised strip 5. The open end of the first concave retaining strip 6 abuts against one end of the first recess. The first concave retaining strip engages with the sample feeding hole side of the first recess 18, engages with the first raised strip 5, and abuts against the edge of the first recess 18.

[0038] The first raised strip on the upper cover and the first concave locking strip on the lower shell work together, indicating that the upper cover and the lower shell have a better fit. This not only better clamps the reagent card and stabilizes it, but also makes the entire casing structure more stable and less prone to detachment. During the detection process, the entire casing needs to be placed in the fluorescence immunoassay analyzer, and it is not easy to separate during the operation of the instrument.

[0039] The inner side of the lower shell is provided with a raised second concave retaining strip 7, which engages with the first raised strip 5. The open end of the second concave retaining strip 7 abuts against one end of the second recess. The second concave retaining strip 7 engages with one side of the second recess, engages with the first raised strip, and abuts against the edge of the second recess.

[0040] The open ends of the first concave retaining strip 6 and the second concave retaining strip 7 are positioned opposite each other. This relative positioning will...

[0041] The first recess 18 and the second recess are clamped together from both sides. The first concave retaining strip 6 and the second concave retaining strip 7 are located on the lower shell and are fixedly connected to the lower shell, thus improving the fixing effect of the upper cover and the lower shell. This prevents separation during instrument operation.

[0042] Furthermore, the first concave strip 6 and the second concave strip 7 are structures that protrude relative to the lower shell 2, so they play a role in controlling the gap between the upper cover and the lower shell, thus preventing the reagent card detection liquid from seeping to both sides and enabling lateral chromatographic flow in chromatographic detection.

[0043] A groove 22 is provided on one side of the first recess 18. The groove 22 is provided with several round holes 23. When the shell is picked up by fingers, the groove 22 and the round holes 23 can reduce the occurrence of slippage.

[0044] Although the specific embodiments of the present utility model have been described above in conjunction with the accompanying drawings, this is not intended to limit the scope of protection of the present utility model. Those skilled in the art should understand that various modifications or variations that can be made by those skilled in the art without creative effort based on the technical solution of the present utility model are still within the scope of protection of the present utility model.

Claims

1. A reagent cartridge for testing whole blood, characterized in that, The device includes a top cover, which has a first recess, a second recess, and a second raised strip. The bottom of the first recess has an elliptical sample application hole, and the back of the sample application hole corresponds to the blood filtration membrane of the reagent card. The second recess corresponds to the nitrocellulose membrane. The second raised strip is located on the back of the top cover and is perpendicular to the direction of the guide groove. The second raised strip is located between the conjugate pad and the nitrocellulose membrane. A first stepped groove is opened on the side of the top cover. The lower shell includes a first concave retaining strip and a second concave retaining strip disposed at the bottom of the lower shell. The side wall of the first concave retaining strip is provided with several protrusions. The first concave retaining strip and the second concave retaining strip, together with the upper cover, form a box structure. A second stepped groove is opened on the side of the lower shell corresponding to the first stepped groove.

2. The whole blood testing reagent cartridge according to claim 1, characterized in that, A cylindrical protrusion is provided at the end of the top cover away from the first recess, and two parallel first protrusion strips are provided on the top cover.

3. The whole blood testing reagent cartridge according to claim 2, characterized in that, The first protrusion is set along the direction of the guide groove, and the distance between the two first protrusions is greater than the width of the guide groove.

4. The whole blood testing reagent cartridge according to claim 1, characterized in that, The inner side of the lower shell is provided with a first concave retaining strip and a second concave retaining strip.

5. A whole blood testing reagent cartridge according to claim 2, characterized in that, The first concave locking strip engages with the first protruding strip, with the open end of the first concave locking strip abutting against one end of the first recess.

6. A whole blood testing reagent cartridge according to claim 1, characterized in that, The second concave locking strip engages with the first protruding strip, with the open end of the second concave locking strip abutting against one end of the second recess.

7. A whole blood testing reagent cartridge according to claim 1, characterized in that, The open ends of the first concave clip and the second concave clip are positioned opposite each other.

8. A whole blood testing reagent cartridge according to claim 1, characterized in that, The first pit is conical.

9. A whole blood testing reagent cartridge according to claim 1, characterized in that, A groove is provided on one side of the first pit.

10. A whole blood testing reagent cartridge according to claim 9, characterized in that, The groove is provided with several circular holes.

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