An antithrombotic polymer, its preparation and use

The antithrombotic polymer prepared by living radical polymerization, combined with photosensitive monomers and zwitterionic units, solves the problems of non-universality and insufficient safety of multi-step reactions in existing antithrombotic coatings, and realizes efficient and robust antithrombotic function regulation and coating application.

CN122297804APending Publication Date: 2026-06-30JIANGSU BIOSURF BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU BIOSURF BIOTECH CO LTD
Filing Date
2024-12-31
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

In the existing technology, the preparation methods of antithrombotic coatings are mostly multi-step reactions and lack universality. It is difficult to achieve fibrinolysis, anti-protein adhesion and hydrophilicity on different material surfaces, and the safety and firmness are insufficient.

Method used

Antithrombotic polymers are prepared by polymerizable fibrinolytic functional monomers, surface adhesive monomers and zwitterionic monomers via living free radical polymerization. Photosensitive monomers are combined to achieve uniform and firm bonding of fibrinolytic functional coatings, and the antithrombotic coating is formed by photocuring.

Benefits of technology

It enables efficient and convenient regulation of antithrombotic function in various medical devices, improves the safety and durability of the coating, is applicable to medical devices with complex structures, reduces costs, and promotes industrialization.

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Abstract

This invention provides an antithrombotic polymer, its preparation method, and its applications. The antithrombotic polymer consists of three parts: A) fibrinolytic functional units; B) surface adhesive units; and C) units containing zwitterionic structures. This not only enables a uniform and robust functional coating on the surface of medical biomaterials, but also allows for efficient regulation of antithrombotic functions through multiple mechanisms to meet the specific needs of different medical devices. Furthermore, the preparation process of this antithrombotic polymer and its application as a coating for medical devices are simpler, facilitating efficient modification of devices with various shapes and special structures.
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Citation Information

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