A cell lysate of a mixed culture fermentation and a preparation method thereof

By using rice mixed fermentation and membrane treatment technology, the problems of low kojic acid yield, dark color, and strong odor in Aspergillus oryzae fermentation have been solved, achieving efficient production of high-concentration clear kojic acid, which is suitable for the cosmetics industry.

CN122344602APending Publication Date: 2026-07-07GUANGZHOU SENSHENG BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU SENSHENG BIOTECHNOLOGY CO LTD
Filing Date
2026-04-14
Publication Date
2026-07-07

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Abstract

The application belongs to the technical field of microbial fermentation, and particularly relates to a kind of cytolysis product of mixed bacteria fermentation and a preparation method. The cytolysis product is prepared by mixed bacteria fermentation of two kinds of aerobic probiotics, i.e. Lactobacillus plantarum and Aspergillus oryzae are used as fermentation strains to carry out mixed bacteria fermentation treatment on rice milk, and membrane filtration and column chromatography system are used for filtration and enrichment, so as to obtain a cytolysis fermentation product filtrate rich in kojic acid, the content of kojic acid is greater than 200 g / L, which is significantly improved compared with conventional process. The obtained cytolysis product has no bad smell and clear color, so that the beneficial function of kojic acid can be played only with a low addition amount in cosmetics, and the addition of odor masking and color correcting auxiliaries is reduced, and the cytolysis product can be used for preparing cosmetics with skin repair, whitening and other functions.
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Citation Information

Patent Citations

  • High-kojic-acid-yield aspergillus oryzae bacterial strain and application thereof

    CN104531536A

  • Method for extracting refined kojic acid from fermentation broth

    CN105837543A

  • Method for increasing yield of aspergillus oryzae kojic acid

    CN106755164A