A thrombus fragmentation and aspiration catheter structure and thrombus treatment interventional device

Abstract

This invention provides a thrombolysis catheter structure and an interventional device for thrombosis treatment, relating to thrombosis treatment medical devices. The device includes a thrombolysis catheter and a thrombolysis head. The proximal end of the thrombolysis catheter is connected to an ultrasonic transducer to receive vibrational energy. The thrombolysis catheter also has a first inlet for introducing thrombolytic agents. The thrombolysis head is fixedly connected to the distal end of the thrombolysis catheter, and the diameter of the thrombolysis head is larger than the diameter of the thrombolysis catheter. The thrombolysis head has a drug chamber that communicates with the distal end of the thrombolysis catheter. The thrombolysis head also has a spray hole communicating with the drug chamber, facing distally. This invention enables simultaneous ultrasonic thrombolysis and drug thrombolysis, allowing mechanical thrombolysis and drug thrombolysis to act simultaneously on the same area of ​​the thrombus, significantly improving thrombosis treatment efficiency. Furthermore, since thrombolysis and thrombolysis are performed concurrently, there is no need to change surgical instruments multiple times to perform the thrombolysis and thrombolysis processes separately, which helps to shorten the operation time.

Description

Technical Field

[0001] This invention relates to a thrombosis treatment medical device, and more particularly to a thrombus fragmentation and thrombolysis catheter structure and an interventional device for thrombosis treatment. Background Technology

[0002] In the field of interventional vascular therapy, lesions with calcified plaques and thrombosis are among the most challenging to manage clinically. Currently, for such complex lesions, a step-by-step approach is typically employed clinically, requiring the alternating use of multiple instruments such as thrombectomy devices, thrombolytic catheters, and thrombus aspiration systems to complete steps such as calcification fragmentation, thrombolysis, and thrombus removal. However, this multi-instrument, step-by-step approach has significant drawbacks: on the one hand, repeated instrument changes and repositioning prolong the overall procedure time, complicate the process, and demand a high level of operator experience; on the other hand, repeated instrument insertions and exits increase the risk of intimal injury, dissection, and even perforation, which is detrimental to postoperative recovery.

[0003] Existing ultrasonic thrombolysis catheters mostly employ a linear ultrasonic transducer structure, where ultrasonic energy propagates unidirectionally along the catheter axis. The fragmentation area is concentrated within a limited range in front of the probe, making it difficult to achieve wide-area fragmentation of eccentric or irregular calcified plaques. Furthermore, the thrombolytic drug's injection channel is often non-axial and non-coplanar with the ultrasonic fragmentation area, preventing the drug from precisely targeting the area of ​​concentrated ultrasonic energy. This limits the thrombolytic effect, reduces drug utilization, and often necessitates increasing the dosage or extending the treatment time, further exacerbating systemic risks such as bleeding.

[0004] Therefore, there is an urgent need to develop a new interventional device that can simultaneously break up calcifications and perform targeted thrombolysis in order to simplify the operation process, shorten the operation time, and reduce the risk of complications. Summary of the Invention

[0005] The purpose of this invention is to provide a thrombolysis catheter structure and an interventional device for thrombus treatment to solve the problems existing in the prior art. It can perform drug thrombolysis while performing ultrasonic thrombolysis. Not only can mechanical thrombolysis and drug thrombolysis act on the same area of ​​the thrombus at the same time, which can significantly improve the efficiency of thrombus treatment, but thrombolysis and thrombolysis can also be performed simultaneously without the need to change surgical instruments to perform the thrombolysis and thrombolysis processes separately, which is beneficial to shorten the operation time.

[0006] To achieve the above objectives, the present invention provides the following solution: A thrombolytic catheter structure includes a thrombolytic catheter and a thrombolytic head. The proximal end of the thrombolytic catheter is connected to an ultrasonic transducer to receive vibration energy. The thrombolytic catheter also has a first inlet for introducing a thrombolytic agent. The thrombolytic head is fixedly connected to the distal end of the thrombolytic catheter, and the diameter of the thrombolytic head is larger than the diameter of the thrombolytic catheter. The thrombolytic head has a drug chamber that communicates with the distal end of the thrombolytic catheter. The thrombolytic head also has a spray hole that communicates with the drug chamber and faces the distal end.

[0007] In one embodiment, the thrombus fragmentation head is a spiral tubular structure, the proximal end of the spiral tubular structure is connected to the distal end of the thrombus fragmentation catheter, the distal end of the spiral tubular structure is sealed, and a plurality of spray holes are spaced apart on the surface of the spiral tubular structure facing the distal end.

[0008] As one embodiment, it also includes an ultrasonic connector for connecting an ultrasonic transducer, the ultrasonic connector having a liquid injection chamber and a liquid injection port communicating with the liquid injection chamber; the proximal end of the thrombectomy tube is fixedly connected to the ultrasonic connector, and the proximal end of the thrombectomy tube serves as the first liquid inlet communicating with the liquid injection chamber.

[0009] As one embodiment, the injection port is connected to an injection conduit, and an injection valve is provided at the end of the injection conduit.

[0010] The present invention also provides an interventional device for thrombosis treatment, including the thrombolytic catheter structure as described above and an outer tube, wherein the outer tube is used to provide an insertion channel to the thrombolytic catheter in the thrombolytic catheter structure; the proximal end of the outer tube is also provided with a second inlet for introducing coolant.

[0011] As one embodiment, the proximal end of the outer tube is also provided with a suction port for aspiration.

[0012] As one embodiment, it also includes a flushing conduit, the proximal end of which is used to connect to an injection device, and the distal end of which is provided with a flushing head. The flushing head has a flushing chamber inside and a flushing hole communicating with the flushing chamber, the flushing hole facing the proximal end.

[0013] In one embodiment, the distal end of the flushing head is a tapered shape with a diameter that gradually decreases from near to far; the thrombectomy head is a spiral tubular structure, the proximal end of the spiral tubular structure is connected to the distal end of the thrombectomy conduit, the distal end of the spiral tubular structure is sealed, and a plurality of spray holes are spaced apart on the surface of the spiral tubular structure facing the distal end, and the flushing head can pass through the middle of the spiral tubular structure.

[0014] As one embodiment, it also includes a catheter seat fixed to the proximal end of the outer tube. The catheter seat has a seat cavity communicating with the proximal end of the outer tube. The catheter seat has a first operating port, a second operating port, and a third operating port communicating with the seat cavity. The first operating port can be used to introduce the thrombolysis catheter structure and the flushing catheter. The second operating port and the third operating port are used to introduce coolant and extract liquid, respectively.

[0015] As one embodiment, a developing structure is provided on the distal sidewall of the outer tube.

[0016] Compared with the prior art, the present invention has the following technical effects: This invention increases the fragmentation area and improves fragmentation efficiency by setting a larger-diameter fragmentation head at the end of the fragmentation catheter. In addition, the invention has a drug injection hole facing the distal end on the fragmentation head. By injecting fragmentation agent into the fragmentation catheter, drug thrombolysis can be performed simultaneously with ultrasonic fragmentation. This not only allows mechanical fragmentation and drug thrombolysis to act on the same area of ​​the thrombus at the same time, significantly improving the efficiency of thrombus treatment, but also eliminates the need to change surgical instruments to perform fragmentation and thrombolysis processes separately, which helps to shorten the operation time.

[0017] The other technical solutions of the present invention can also produce the following technical effects compared with the prior art: In this embodiment, the proximal end of the outer tube is also provided with a suction port for aspiration. The suction port is connected to a negative pressure aspiration device, which can extract the thrombus particles generated during the thrombus fragmentation and thrombolysis process from the body, and prevent the thrombus particles from flowing with the blood and causing terminal vascular embolism. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the structure of the thrombus fragmentation catheter in one embodiment of the present invention; Figure 2 A schematic diagram of the distal end face structure of a thrombolysis catheter. Figure 3 This is a schematic diagram of the structure of a thrombolytic catheter in one embodiment of the present invention; Figure 4 This is a schematic diagram of the structure of the outer tube and the guide tube seat in one embodiment of the present invention; Figure 5 for Figure 4 Enlarged view of the structure of A in the middle; Figure 6 This is a schematic diagram of the connection of the interventional device for thrombosis treatment in one embodiment of the present invention; Figure 7 for Figure 6 Enlarged view of the structure of B in the middle; Figure 8 This is a schematic diagram of the structure of the flushing conduit in one embodiment of the present invention; Figure 9 for Figure 8 Enlarged view of the structure of C in the middle; Figure 10 A schematic diagram of the internal structure of the flushing conduit and flushing head; Figure 11 This is a schematic diagram of the structure of the outer tube and the fragmented thrombus catheter inserted into the affected area in one embodiment of the present invention; Figure 12 A schematic diagram illustrating the initiation of ultrasonic vibration for thrombus fragmentation; Figure 13 A schematic diagram illustrating the process of initiating ultrasonic vibration followed by the injection of thrombolytic agents for thrombus treatment. Figure 14 This is a schematic diagram illustrating the flushing and aspiration of thrombus particles. Figure 15 This is a schematic diagram of the structure of an ultrasonic host in one embodiment of the present invention; Figure 16 This is a schematic diagram of the structure of an ultrasonic transducer in one embodiment of the present invention; Figure 17 This is a schematic diagram of the foot switch in one embodiment of the present invention.

[0020] Figure label: 1. Thrombus fragmentation catheter; 2. Thrombus fragmentation head; 3. Spray nozzle; 4. Ultrasonic connector; 5. Injection catheter; 6. Injection valve; 7. Outer tube; 8. Flushing catheter; 9. Flushing head; 10. Flushing port; 11. Catheter seat; 12. First operating port; 13. Second operating port; 14. Third operating port; 15. Imaging structure; 16. Ultrasonic main unit; 17. Foot switch; 18. Ultrasonic transducer. Detailed Implementation

[0021] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0022] The purpose of this invention is to provide a thrombolysis catheter structure and an interventional device for thrombus treatment to solve the problems existing in the prior art. It can perform drug thrombolysis while performing ultrasonic thrombolysis. Not only can mechanical thrombolysis and drug thrombolysis act on the same area of ​​the thrombus at the same time, which can significantly improve the efficiency of thrombus treatment, but thrombolysis and thrombolysis can also be performed simultaneously without the need to change surgical instruments to perform the thrombolysis and thrombolysis processes separately, which is beneficial to shorten the operation time.

[0023] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0024] Example 1: like Figures 1-3 As shown, this embodiment provides a thrombolytic catheter structure, including a thrombolytic catheter 1 and a thrombolytic head 2. The proximal end of the thrombolytic catheter 1 is used to connect to an ultrasonic transducer 18. In this embodiment, the thrombolytic catheter 1 is made of metal, which can effectively transmit vibration energy. The thrombolytic catheter 1 is also provided with a first inlet for introducing thrombolytic agents. The first inlet can be the proximal end of the thrombolytic catheter 1, or an opening on the side wall of the thrombolytic catheter 1, or the opening of a branch pipe connected to the side wall; moreover, in addition to introducing thrombolytic agents for thrombolysis, other appropriate agents can also be introduced into the first inlet according to other actual conditions. In this embodiment, the fragmentation head 2 is fixedly connected to the distal end of the fragmentation catheter 1, and the diameter of the fragmentation head 2 is larger than the diameter of the fragmentation catheter 1; the fragmentation head 2 has a drug chamber, which is connected to the distal end of the fragmentation catheter 1; the fragmentation head 2 is also provided with a spray hole 3 that is connected to the drug chamber, the spray hole 3 is located on the end face of the fragmentation head 2 facing the distal end, and the spray hole 3 also faces the distal end, that is, sprays the drug towards the thrombus.

[0025] It should be noted that in this embodiment, "proximal end" refers to the end closer to the surgeon, and "distal end" refers to the end farther away from the surgeon.

[0026] In use, the proximal end of the thrombectomy catheter 1 is connected to the ultrasonic transducer 18. The distal end of the thrombectomy catheter 1 is inserted into the body. After the thrombectomy head 2 reaches the affected area, the ultrasonic transducer 18 is activated. The thrombectomy catheter 1 and the thrombectomy head 2 vibrate under the action of ultrasonic energy. The thrombectomy head 2 vibrates and breaks up the thrombus. During the thrombectomy process, the operator can pull the thrombectomy catheter 1 back and forth to adjust the position of the thrombectomy head 2. At the same time, thrombolytic agents are injected into the thrombectomy catheter 1. The thrombolytic agents are sprayed from the spray hole 3 on the thrombectomy head 2 onto the thrombus to dissolve the thrombus.

[0027] Therefore, by setting a larger diameter thrombectomy head 2 at the end of the thrombectomy catheter 1, this embodiment can increase the thrombectomy area and improve the thrombectomy efficiency. In addition, this embodiment sets a drug spraying hole 3 facing the distal end on the thrombectomy head 2. By injecting thrombectomy agent into the thrombectomy catheter 1, drug thrombolysis can be performed simultaneously with ultrasonic thrombectomy. This not only allows mechanical thrombectomy and drug thrombolysis to act on the same area of ​​the thrombus at the same time, significantly improving the thrombus treatment efficiency, but also allows thrombectomy and thrombolysis to be performed simultaneously, eliminating the need to change surgical instruments multiple times to perform the thrombectomy and thrombolysis processes separately, which helps to shorten the operation time.

[0028] In this embodiment, there are multiple spray holes 3. These multiple spray holes 3 can be distributed in a single circular trajectory or in multiple concentric circular trajectories. Furthermore, the circular trajectories of the spray holes 3 are coaxial with the tinder head 2.

[0029] In this embodiment, the puncture head 2 can be spherical or other shapes. When the puncture head 2 is spherical, the spray hole 3 is set on the spherical surface facing the far end.

[0030] In this embodiment, the thrombectomy head 2 is a helical tubular structure (a helical structure formed by a catheter). The proximal end of the helical tubular structure is connected to the distal end of the thrombectomy catheter 1, and the axial direction of the helical tubular structure (this axial direction refers to the overall axial direction of the helical structure, not the axial direction of the catheter forming the helical shape) is coaxial with the thrombectomy catheter 1, ensuring that the vibration energy is distributed as evenly as possible and ensuring the thrombectomy efficiency at all points at the distal end of the thrombectomy head 2. The distal end of the helical tubular structure is sealed, and multiple spray holes 3 are spaced apart on the surface of the helical tubular structure facing the distal end. The position of the spray holes 3 on the helical tubular structure is explained below. The location of the spray holes 3 is the point closest to the distal end on the radial cross section of the catheter in the helical tubular structure at this point, thereby achieving coplanar coupling of the thrombectomy end face and the thrombolysis end face, that is, the thrombolysis area is also the thrombectomy area, thereby improving the thrombus treatment effect.

[0031] like Figure 3 As shown, this embodiment also includes an ultrasonic connector 4 for connecting the ultrasonic transducer 18. The ultrasonic connector 4 has a liquid injection chamber and a liquid injection port communicating with the liquid injection chamber. The proximal end of the thrombectomy tube 1 is fixedly connected to the ultrasonic connector 4, and the proximal end of the thrombectomy tube 1 serves as the first liquid inlet communicating with the liquid injection chamber.

[0032] As one embodiment, in this embodiment, the injection port is connected to an injection conduit 5, and the end of the injection conduit 5 is provided with an injection valve 6. After the injection conduit 5 is connected to an injection pump or other injection equipment, the injection flow rate is adjusted by the injection valve 6.

[0033] Example 2: like Figures 1-17As shown, this embodiment provides an interventional device for thrombosis treatment, including the thrombolysis catheter structure of Embodiment 1 and an outer tube 7. The outer tube 7 is used to provide an insertion channel to the thrombolysis catheter 1 in the thrombolysis catheter structure. In use, the outer tube 7 is first inserted into the body via a guide wire, and then the thrombolysis catheter 1 is inserted into the body through the outer tube 7 and reaches the affected area. The proximal end of the outer tube 7 is also provided with a second inlet for introducing coolant. The second inlet can be the proximal port of the outer tube 7, or an opening on the side wall of the outer tube 7, or the port of a branch tube connected to the side wall.

[0034] The heat generated during ultrasonic thrombolysis is one of its main side effects. If left uncontrolled, the accumulated heat over a long period can cause burning discomfort and even tissue damage. Studies have shown that at appropriate ultrasound doses, the increase in fluid temperature during thrombosis experiments is limited, and the thermal effect itself is not the primary mechanism of thrombolysis, but its cumulative effect still needs monitoring. Therefore, active cooling is an effective safety measure. In this embodiment, coolant is injected through the external tube 7, which cools the thrombolysis catheter 1 and the thrombolysis head 2, preventing heat accumulation. While the coolant in this embodiment will mix into the bloodstream after cooling the thrombolysis catheter 1 and the thrombolysis head 2, clinical trials have shown that the risks associated with using coolant to cool the thrombolysis structure are controllable and clinically accepted.

[0035] In this embodiment, the coolant can be physiological saline or heparinized physiological saline (physiological saline with a small amount of anticoagulant heparin added).

[0036] In this embodiment, the proximal end of the outer tube 7 is also provided with a suction port for aspiration. The suction port can be the proximal end of the outer tube 7, or an opening on the side wall of the outer tube 7, or the opening of another branch tube connected to the side wall. The suction port is connected to a negative pressure aspiration device, which can remove thrombus particles generated during thrombus fragmentation and thrombolysis from the body, preventing thrombus particles from flowing with the blood and causing distal vascular embolism.

[0037] If the outer tube 7 has only one lumen, then both the injection of coolant and the removal of thrombus particles need to be achieved through the lumen. In this case, the injection of coolant and the removal of thrombus particles can be carried out separately. That is, after the coolant is introduced and the thrombus is broken up and dissolved for a certain period of time, the process of breaking up and dissolving the thrombus is stopped, and the thrombus particles are aspirated for a certain period of time.

[0038] If the outer tube 7 has two or more lumens extending parallel to each other along its length, since the multiple lumens do not interfere with each other, one lumen can be used to insert the thrombus fragmentation catheter 1 and inject coolant, while the other lumen can be connected to a negative pressure aspiration device to aspirate the thrombus particles. In this case, the thrombus fragmentation and thrombolysis processes can be carried out simultaneously with the thrombus particle aspiration process.

[0039] like Figure 8As shown, this embodiment also includes a flushing conduit 8. The proximal end of the flushing conduit 8 is used to connect to the injection device. The distal end of the flushing conduit 8 is provided with a flushing head 9. The flushing head 9 has a flushing chamber inside. The flushing head 9 is also provided with a flushing hole 10 that communicates with the flushing chamber. The flushing hole 10 faces the proximal end.

[0040] During use, the flushing catheter 8 is also inserted into the affected area through the outer tube 7. After the thrombus fragmentation and dissolution process has lasted for a certain period, the thrombus fragmentation catheter 1 is appropriately withdrawn, allowing the flushing head 9 to protrude from the distal end of the thrombus fragmentation head 2. Then, flushing fluid (which can be physiological saline) is injected into the flushing catheter 8, while simultaneously, a negative pressure suction device is activated at the proximal end of the outer tube 7 to aspirate the thrombus particles. Because the flushing port on the flushing head 9 faces proximally in this embodiment, the force exerted by the flushing fluid from the flushing head 9 on the thrombus particles and the suction force exerted by the negative pressure suction device on the thrombus particles are approximately in the same direction (after orthogonal decomposition of the direction of the flushing fluid from the flushing head 9, at least one component direction is in the same direction as the suction force), thereby improving the efficiency of thrombus particle aspiration.

[0041] like Figure 9 As shown, in this embodiment, the distal end of the flushing head 9 is a tapered shape with its diameter gradually decreasing from proximal to distal. The larger diameter end of the tapered shape is connected to the distal end of the flushing catheter 8 via a frustum-shaped structure. The diameter of the frustum-shaped structure gradually increases from proximal to distal. Multiple flushing holes 10 are arranged on the surface of the frustum-shaped structure in a circular pattern. The flushing port can have a certain angle with the axial direction and face towards the inner wall of the blood vessel; that is, the liquid surface sprayed from the flushing head 9 is a tapered surface with a gradually increasing diameter from distal to proximal. The flushing head 9 can extend through the middle of the spiral tubular structure. During flushing, the flushing head 9 agitates the body fluid, causing thrombus particles near the vessel wall to float in the body fluid, thus facilitating aspiration.

[0042] In this embodiment, the proximal end of the irrigation catheter 8 can also be connected to a rotating mechanism, or the operator can manually rotate it to make the distal irrigation head 9 rotate during the irrigation process, so as to increase the irrigation range.

[0043] It should be noted that in this embodiment, the outer diameter of the flushing catheter 8 and the thrombus fragmentation catheter 1 is significantly smaller than the inner diameter of the outer tube 7, which can be 1 / 5 to 1 / 3 of the inner diameter of the outer tube 7. Even if the flushing catheter 8 and the thrombus fragmentation catheter 1 are inserted at the same time, the inner diameter of the outer tube 7 still has enough space for the aspiration of thrombus particles.

[0044] This embodiment also includes a catheter seat 11 fixed to the proximal end of the outer tube 7. The catheter seat 11 has a seat cavity communicating with the proximal end of the outer tube 7. The catheter seat 11 has a first operating port 12, a second operating port 13, and a third operating port 14 communicating with the seat cavity. The first operating port 12 can be used to introduce the thrombolysis catheter structure and the flushing catheter 8. The first operating port 12 is coaxially arranged with the outer tube 7 and has a sealing structure. The thrombolysis catheter 1 and the flushing catheter 8 in the thrombolysis catheter structure pass through the sealing structure in parallel. The sealing structure can prevent the drug solution injected from the outer tube 7 or the body fluid containing thrombus particles aspirated from the first operating port 12 from flowing out. The second operating port 13 and the third operating port 14 are used to introduce coolant and to aspirate liquid, respectively.

[0045] In this embodiment, a radiographic structure 15 is provided on the distal sidewall of the outer tube 7 to allow the surgeon to determine the position of the distal end of the outer tube 7.

[0046] like Figures 15-17 As shown, this embodiment also includes an ultrasonic main control component, which includes an ultrasonic host 16 and a foot switch 17. The ultrasonic host 16 is connected to the ultrasonic transducer 18 via a wire and is also connected to the foot switch 17 via a wire. The operator can start the ultrasonic transducer 18 by stepping on the foot switch 17.

[0047] Any adaptive changes made according to actual needs are within the scope of protection of this invention.

[0048] Specific examples have been used to illustrate the principles and implementation methods of this invention. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of this invention. Furthermore, those skilled in the art will recognize that, based on the ideas of this invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this invention.

Claims

1. A thrombolysis catheter structure, characterized in that, include: A thrombectomy catheter, the proximal end of which is used to connect to an ultrasonic transducer to receive vibrational energy; The thrombus fragmentation catheter is also provided with a first inlet for introducing thrombolytic agents; The device includes a thrombectomy head, which is fixedly connected to the distal end of the thrombectomy conduit, and the diameter of the thrombectomy head is larger than the diameter of the thrombectomy conduit. The thrombectomy head has a drug chamber that communicates with the distal end of the thrombectomy conduit. The thrombectomy head is also provided with a spray hole that communicates with the drug chamber and faces the distal end.

2. The thrombolysis catheter structure according to claim 1, characterized in that, The thrombus fragmentation head is a spiral tubular structure, with the proximal end of the spiral tubular structure connected to the distal end of the thrombus fragmentation catheter. The distal end of the spiral tubular structure is sealed, and multiple spray holes are spaced apart on the surface of the spiral tubular structure facing the distal end.

3. The thrombolysis catheter structure according to claim 1, characterized in that, It also includes an ultrasonic connector for connecting an ultrasonic transducer, the ultrasonic connector having a liquid injection chamber and a liquid injection port communicating with the liquid injection chamber; the proximal end of the thrombectomy tube is fixedly connected to the ultrasonic connector, and the proximal end of the thrombectomy tube serves as the first liquid inlet communicating with the liquid injection chamber.

4. The thrombolysis catheter structure according to claim 3, characterized in that, The injection port is connected to an injection conduit, and an injection valve is provided at the end of the injection conduit.

5. A thrombosis treatment interventional device, characterized in that, include: The thrombolysis catheter structure as described in any one of claims 1-4; The outer tube is used to provide an insertion channel for the thrombolytic catheter in the thrombolytic catheter structure; the proximal end of the outer tube is also provided with a second inlet for coolant to flow in.

6. The interventional device for thrombosis treatment according to claim 5, characterized in that, The proximal end of the outer tube is also provided with a suction port for aspiration.

7. The interventional device for thrombosis treatment according to claim 6, characterized in that, It also includes a flushing conduit, the proximal end of which is used to connect to an injection device, and the distal end of which is provided with a flushing head. The flushing head has a flushing chamber inside and a flushing hole communicating with the flushing chamber, with the flushing hole facing the proximal end.

8. The interventional device for thrombosis treatment according to claim 7, characterized in that, The distal end of the flushing head is a tapered shape with a diameter that gradually decreases from near to far; the thrombus-breaking head is a spiral tubular structure, the proximal end of which is connected to the distal end of the thrombus-breaking catheter, the distal end of which is sealed, and a plurality of spray holes are spaced apart on the surface of the spiral tubular structure facing the distal end, and the flushing head can pass through the middle of the spiral tubular structure.

9. The interventional device for thrombosis treatment according to claim 7, characterized in that, It also includes a catheter seat fixed to the proximal end of the outer tube. The catheter seat has a seat cavity communicating with the proximal end of the outer tube. The catheter seat has a first operating port, a second operating port, and a third operating port communicating with the seat cavity. The first operating port can be used to introduce the thrombolytic catheter structure and the flushing catheter. The second operating port and the third operating port are used to introduce coolant and extract liquid, respectively.

10. The interventional device for thrombosis treatment according to claim 5, characterized in that, A developing structure is provided on the distal sidewall of the outer tube.

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