A high-efficiency extraction method and application of total alkaloids from fritillaria cirrhosa bulb
By employing ultrasonic synergistic inclusion pretreatment and multi-stage resin column purification technology, the problems of low extraction rate and insufficient purity of Fritillaria cirrhosa alkaloids have been solved, achieving efficient and environmentally friendly preparation of high-purity alkaloids suitable for pharmaceutical formulations for chronic respiratory diseases.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SICHUAN GUKANG PHARM CO LTD
- Filing Date
- 2026-06-05
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies for extracting alkaloids from Fritillaria cirrhosa have problems such as low extraction rate of active ingredients, many impurities, and high energy consumption. Furthermore, traditional methods are difficult to achieve high purity and large-scale production.
The extraction rate and purity were improved by employing ultrasonic synergistic inclusion pretreatment, compound acid enhanced extraction, multipolar resin enrichment and HSCCC purification technology, combined with β-cyclodextrin and β-glucan complex inclusion agents to enhance cell wall permeability, and purification by multi-stage resin column and high-speed countercurrent chromatography.
It significantly improves the extraction rate and purity of total alkaloids, meets the quality standards for high-value pharmaceutical raw materials, and is suitable for the development of modern pharmaceutical formulations, especially lung-inhaled targeted formulations.
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Abstract
Citation Information
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