Time-interleaved OSA stimulation system based on pulse amplitude modulation and multi-modal closed loop

CN122399241APending Publication Date: 2026-07-17BEIJING UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-30
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing treatments for obstructive sleep apnea (OSA), such as CPAP and hypoglossal nerve stimulation devices, suffer from discomfort when worn, significant surgical trauma, high costs, and problems with DC bias accumulation. Traditional time-intervention (TI) technology has high power consumption, is difficult to miniaturize, and lacks a closed-loop regulation mechanism.

Method used

A time-interference OSA stimulation system based on pulse amplitude modulation and multimodal closed loop is adopted. The STM32F407 chip generates a high-frequency PWM carrier signal, which is combined with PAM modulation and active charge balance feedback module to achieve non-invasive and adaptive nerve stimulation. A time-interference electric field is formed in the deep region through multimodal electrode array, and the current guidance and frequency are dynamically adjusted to achieve closed-loop control.

Benefits of technology

It achieves non-invasive, painless, and low-power nerve stimulation, avoids the trauma of implantation surgery, meets the requirements of portable design, ensures tissue safety and high energy efficiency for long-term use, and has real-time closed-loop regulation capability.

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Abstract

本申请公开了一种基于脉幅调制与多模态闭环的时间干涉OSA刺激系统,涉及医疗设备领域,包括主控模块生成PWM载波信号,根据宏观生理信号判定睡眠呼吸暂停事件及呼吸相位,根据微观靶点响应信号判定刺激焦点准确性、肌肉疲劳状态及电极贴敷状态,并动态调整电流导向比例和干涉包络频率。信号发生模块生成两路低频正弦基带信号;PAM调制与驱动模块根据低频正弦基带信号和PWM载波信号生成脉冲幅度调制波形。精密压控恒流源模块将脉冲幅度调制波形转换为恒定电流输出。主动电荷平衡反馈模块实时消除输出电极上的直流偏置分量。多模态电极阵列施加两路高频电流以在深部目标区域形成时间干涉电场。本申请具有低功耗、无创无痛、组织安全性高以及自适应闭环调节等优点。
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