A fermentation medium and a fermentation method for high-yield milbemycins
By using a low-cost culture medium formulation and segmented fermentation parameter control, the problems of high production cost and unreasonable composition of milbemycin have been solved, achieving efficient, low-cost, and stable production of milbemycin with stable potency and excellent composition.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHEJIANG HUIDA BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-05-06
- Publication Date
- 2026-07-17
AI Technical Summary
The existing milbemycin production has high costs, unreasonable component ratios, high impurity content, and poor compatibility between fermentation process parameters and strain metabolic characteristics, resulting in large fluctuations in production potency and making it difficult to achieve stable and efficient production.
A low-cost culture medium formula is adopted, using industrial by-products such as glucose mother liquor, malt residue, and soybean meal residue to replace high-quality raw materials. Combined with segmented fermentation parameter control, the requirements of the strain growth stage are precisely matched, the component ratio is optimized, and the impurity content is reduced.
The drug achieved a stable milbemycin potency of around 7000 μg/mL, optimized the proportion of core components, reduced impurity content to ≤0.5%, and achieved a product purity of ≥98.6%, while reducing culture medium and overall production costs by 25-30%.
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Abstract
Citation Information
Patent Citations
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