Formed component detection housing and detection device
By designing a formed element detection and containment device that integrates microscopic magnification imaging and optical detection, the problem of integrating multiple detection items in pet hospitals has been solved, realizing efficient and accurate multi-detection functions, which is suitable for the high-end instrument needs of pet hospitals.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHENZHEN ANLV MEDICAL TECH CO LTD
- Filing Date
- 2025-01-23
- Publication Date
- 2026-07-24
Smart Images
Figure CN122448842A_ABST
Abstract
Description
Technical Field
[0001] This application belongs to the field of medical device technology, and in particular relates to a container for the detection of formed elements and a detection device. Background Technology
[0002] Medical testing analytical devices include a variety of instruments, which can be classified in various ways according to their function or detection principle, such as:
[0003] Type A: Detection devices based on the optical reaction characteristics of samples, such as flow cytometers and biochemical analysis instruments. These devices detect light energy based on the transmission, scattering, or absorption characteristics of different substances in the sample, thereby obtaining information about the composition or content of the corresponding components.
[0004] Type B: Devices for the quantitative and qualitative detection of trace amounts of immunomarkers. These instruments operate on complex principles and include enzyme-linked immunosorbent assay (ELISA), radioimmunoassay, immunoturbidimetric assay, immunofluorescence assay, and chemiluminescence immunoassay. Most utilize optical properties for detection. Type C: Devices based on microscopic magnification for the analysis of formed elements. Examples include blood analyzers for detecting white blood cells and red blood cells, and urine analyzers for detecting crystalline components in urine.
[0005] Patients entering the hospital need to undergo various tests and use different instruments, which takes a long time and is costly.
[0006] With the development of the pet economy, pet hospitals have increasingly higher requirements for high-end equipment. However, pet hospitals are sensitive to the cost of equipment investment, and at the same time, the area of pet hospitals is limited, making it difficult to accommodate a large number of instruments and equipment.
[0007] The applicant has filed a series of Chinese patents, such as
[0008] 1. CN2020112669290, "Cellular analysis methods and systems and quantitative methods and systems";
[0009] 2. CN2022104799126, "A method for rapid focusing of a microscopic image acquisition device and a method for detecting microscopic images";
[0010] 3. CN2023100423151, "Blood Imaging Analysis System and Method".
[0011] This application employs a novel technological solution, leveraging artificial intelligence to measure the content of formed elements in blood samples. Traditional testing methods, such as hematocrit and immunoassay, still require additional instruments. The technical challenge this application aims to address is how to integrate hematocrit or immunoassay tests into a single formed element detection device.
[0012] The applicant also filed a series of Chinese patents, such as
[0013] 4. CN2020226212835, "Integrated Reagent Kit";
[0014] 5. CN2020226244056 "Integrated Reagent Kit";
[0015] 6. CN2020112692418 "Integrated Reagent Kit".
[0016] These patents propose integrating the detection site with the reagent containing chamber, thus merging the reagent storage device and the detection device into a single unit. However, these devices have high requirements during the sample addition process of formed elements. This application also proposes a device for convenient sample addition during detection. Summary of the Invention
[0017] This application proposes a formed element detection and containment device, including at least two cavities, cavity A for formed element analysis and cavity E for containing sample E in static stratification, thereby enabling the calculation of the volume or volume percentage of the corresponding component based on the static stratification.
[0018] The solution to the above-mentioned technical problem is a formed element detection and containment device, including a detection unit A and a detection unit E; the detection unit A includes a cavity A, which is used to contain sample A and to capture a magnified microscopic image of the microscopically examined sample, and the magnified microscopic image is used for formed element analysis; the detection unit E includes a cavity E; the cavity E is used to contain sample E in static stratification; the stratification information of sample E is used to calculate the volume of the components in the formed elements.
[0019] Alternatively, the detection unit E may also include a sample inlet E; the cavity E is connected to the sample inlet E; the detection unit A may also include a sample inlet A; the cavity A is connected to the sample inlet A.
[0020] It may also include a detection unit B, which includes a cavity B and a sample dispensing port B, with the cavity B and the sample dispensing port B connected. The cavity B is used to contain the sample B and is used for optical detection and analysis of the sample. The optical detection and analysis is used for biochemical detection and analysis or immunoassay analysis of the sample B.
[0021] It is possible that cavity A is used for formed element analysis; the aforementioned formed element analysis includes any one or more of morphological analysis, biochemical analysis, and immunoassay analysis.
[0022] It is permissible that the cross-section of the sample inlet E is larger than the cross-section of the cavity E.
[0023] Yes, the sample mentioned above is blood, and the stratification information mentioned above is used to detect the hematocrit of the blood.
[0024] Alternatively, the detection unit A may also include a sample loading chamber A, a sample loading port A, an exhaust chamber A, and an exhaust port A. The bottom of the sample loading chamber A is connected to the chamber A, and the sample loading port A is connected to the sample loading chamber A. The bottom of the exhaust chamber A is connected to the chamber A, and the exhaust port A is connected to the exhaust chamber A. The center position of the sample loading chamber A is higher than the center position of the chamber A. The center position of the exhaust chamber A is higher than the center position of the chamber A.
[0025] It may also include a detection unit C, which includes at least one set of chambers C and a sample dispensing port C. The chambers C are used to contain the detection reagents, and the sample dispensing port C is open upwards. Liquid is added to or removed from the chambers C through the sample dispensing port C. The chambers C are used to contain any one of staining reagents, biochemical detection reagents, or immunoassay reagents.
[0026] It is possible that the cavity heights of cavities B, C, and E are consistent.
[0027] The solution to the above-mentioned technical problems in this application can also be a detection device for use in conjunction with a formed element detection and containment device; including a microscopic magnification digital imaging component and a layer detection component; the microscopic magnification digital imaging component is used to capture microscopic magnified images of the microscopically examined sample; to obtain an image of the sample in cavity A for formed element analysis; the layer detection component is used to obtain layer information of sample E.
[0028] Alternatively, the aforementioned layer detection component may include a camera device, which acquires a photograph of sample E and obtains layer information of sample E through the photograph.
[0029] It can be that the light in the optical detection component irradiates the sample in cavity B of the external multifunctional detection device, and the sample is subjected to biochemical detection analysis or immunoassay analysis based on the optical reaction characteristics of the sample; the optical detection component includes a light source and a light detection component; the light source irradiates the cavity B, and the light detection component acquires the light passing through the cavity B to obtain the optical reaction characteristic information of the sample.
[0030] The technical effects of the above solution are: cavity A is used for formed element analysis, and cavity E is used to contain sample E for static stratification, providing a basis for more accurate volume ratio calculation.
[0031] The technical advantages of the above solution are: chamber E and chamber A each have their own sample dispensing ports, facilitating the addition of samples in different states or different samples. In some cases, samples with different dilution ratios can be added, facilitating corresponding detection.
[0032] The technical advantages of the above solution are: cavity A is used for the analysis of formed elements, including morphological analysis, biochemical analysis and immunoassay analysis, and can perform analysis of a variety of items, with good adaptability.
[0033] The technical effects of the above solution are: the cross-section of the sample inlet E is larger than the cross-section of the cavity E; it facilitates the addition of samples, facilitates the collection and stratification of liquid in the cavity E, and improves the accuracy of calculations.
[0034] The technical effects of the above-mentioned technical solution are as follows: the above-mentioned sample is blood, the above-mentioned layer information is used to detect the blood infiltration, and the formed element detection and containment device can be used for microscopic magnified image analysis of formed elements, and can also accurately calculate the infiltration at the same time.
[0035] The technical effects of the above solution are: the center position of the sample loading chamber A is higher than the center position of the chamber A; the center position of the exhaust chamber A is higher than the center position of the chamber A, which facilitates the flow and spreading of the sample in the chamber A.
[0036] The technical advantages of the above solution are as follows: Cavity A, the formed element detection cavity, is used to capture magnified microscopic images of the microscopic sample; Cavity B, the optical detection cavity, is used for optical detection and analysis of the sample. This makes the sample containment device suitable for different application scenarios, including comprehensive applications. It can be used for microscopic digital imaging analysis of formed elements, as well as for biochemical and immunological detection analysis. The material of Cavity B meets the corresponding optical characteristic requirements and can be made of materials with different optical properties, such as glass, sapphire, or transparent plastic.
[0037] The technical effect of the above solution is that, like the detection unit B, the detection unit C can increase the capacity for one more sample.
[0038] The technical effect of the above technical solution is that the cavity C in the detection section C is used to accommodate staining reagents; or the cavity C is used to accommodate immunoassay reagents or biochemical assay reagents; providing storage space for reagents in the process, so that the reagent and sample containing device can be integrated.
[0039] The technical effect of the above solution is that the cavity heights of cavities B, C, and E are consistent, which facilitates manufacturing and comparison of sample storage volumes between different cavities.
[0040] The technical effects of the above-mentioned technical solution are: the detection device can acquire magnified microscopic images; perform formed element analysis based on the images; and perform accurate compaction calculations.
[0041] The technical effect of the above technical solution is that the detection device can perform biochemical detection and analysis or immunoassay analysis of the sample based on the optical reaction characteristics of the sample, while completing the analysis of formed elements and the calculation of the volume. Attached Figure Description
[0042] Figure 1 This is a schematic block diagram of the detection device;
[0043] Figure 2This is a schematic diagram of the detection device;
[0044] Figure 3 This is a schematic block diagram of the detection device;
[0045] Figure 4 This is a schematic diagram of the detection device;
[0046] Figure 5 This is a schematic diagram of a formed element detection and containment device;
[0047] Figure 6 This is a schematic diagram of a formed element detection and containment device;
[0048] Figure 7 This is a bottom schematic diagram of the formed element detection and containment device;
[0049] Figure 8 This is a schematic diagram of the disassembled state of the formed element detection and containment device;
[0050] Figure 9 This is a cross-sectional schematic diagram of a formed element detection and containment device;
[0051] Figure 10 This is a cross-sectional schematic diagram of a formed element detection and containment device;
[0052] Figure 11 This is a cross-sectional schematic diagram of a formed element detection and containment device. Detailed Implementation
[0053] The contents of this application will be further described in detail below with reference to the accompanying drawings.
[0054] It should be noted that the following description of preferred embodiments of this application does not constitute any limitation on this application. The description of preferred embodiments is merely an illustration of the general principles of this application. The embodiments described in this application are only some embodiments of this application, and not all embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0055] In the description of this application, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the equipment or component referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on this application. Furthermore, the terms "first," "second," and technical features numbered with Arabic numerals 1, 2, 3, etc., and designations such as "A" and "B," are used for descriptive purposes only, for ease of explanation, and do not represent a temporal or spatial order; they should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, features defined with "first," "second," and numbered with Arabic numerals 1, 2, 3, etc., may explicitly or implicitly include one or more of that feature. In the description of this application, "several" means two or more, unless otherwise expressly and specifically defined.
[0056] like Figures 1 to 2 An embodiment of a formed element detection and containment device includes a detection unit A and a detection unit E; the detection unit A includes a cavity A, i.e., a formed element detection cavity, which is used to contain sample A and to capture a magnified microscopic image of the microscopically examined sample, the magnified microscopic image being used for formed element analysis; the detection unit E includes a cavity E, i.e., a compaction detection cavity; the cavity E is used to contain the static stratification of sample E; the stratification information of sample E is used to calculate the volume of components in the formed elements.
[0057] like Figure 5 The detection unit E also includes a sample dispensing port E; the cavity E is connected to the sample dispensing port E; the detection unit A also includes a sample dispensing port A; the cavity A is connected to the sample dispensing port A. In some embodiments, the compaction detection cavity is provided with scale lines to distinguish stratification state information.
[0058] like Figures 3 to 4 and Figure 5 An embodiment of a formed element detection and containment device further includes a detection unit B, which includes a cavity B and a sample dispensing port B, the cavity B being connected to the sample dispensing port B; the cavity B is used to contain sample B and is used for optical detection and analysis of the sample, the optical detection and analysis being used for biochemical detection and analysis or immunoassay analysis of sample B. The cavity A is used for formed element analysis; the formed element analysis includes any one or more of morphological analysis, biochemical analysis, and immunoassay analysis.
[0059] like Figures 6 to 9An embodiment of a formed element detection and containment device, wherein the cross-section of the sample inlet E is larger than the cross-section TA30 of the cavity E; the sample is blood; and the layering information is used to detect the blood hematoma.
[0060] like Figures 5 to 6 An embodiment of a formed element detection and containment device includes a detection unit A further comprising a sample addition chamber A, a sample addition port A, an exhaust chamber A, and an exhaust port A. The bottom of the sample addition chamber A is connected to the cavity A, and the sample addition port A is connected to the sample addition chamber A. The bottom of the exhaust chamber A is connected to the cavity A, and the exhaust port A is connected to the exhaust chamber A. The center position of the sample addition chamber A is higher than the center position of the cavity A. The center position of the exhaust chamber A is higher than the center position of the cavity A.
[0061] like Figure 7 A schematic diagram of the bottom of the formed element detection and containment device; G1 in the figure is the bottom of the sample addition chamber A, and G2 in the figure is the bottom of the exhaust chamber A.
[0062] like Figure 8 A schematic diagram of the disassembled state of the formed element detection and containment device; a sealing membrane covers the upper part of the above-mentioned multiple sample addition chambers, and external devices can pass through the sealing membrane.
[0063] Figure 9 yes Figure 8 A schematic cross-sectional view of section E; as shown. Figure 9 The sample application port E has a cross-section larger than the cross-section TA30 of the cavity E. The sample is blood, and the stratification information is used to detect the blood hematocrit. The width of cross-section E1 is greater than the width of cross-section E2; the cavity E is wider at the top and narrower at the bottom. In some embodiments, the sample application cavity A or cavity A is connected to cavity E. In other embodiments, cavity B is connected to cavity E. In still other embodiments, cavity B can also function as cavity E.
[0064] Figure 10 yes Figure 8 Schematic sectional view of mid-section A1; Figure 11 yes Figure 8 A cross-sectional view of section A2; the inner diameter of the sample feeding chamber A is larger than the inner diameter of the exhaust chamber.
[0065] In some embodiments, the cavity E is provided with scale lines to mark the layering positions.
[0066] like Figures 5 to 6 An embodiment of a formed element detection and containment device further includes a detection unit C, which includes at least one set of cavities C and a sample dispensing port C. The cavities C are used to contain detection reagents, and the sample dispensing port C is open upward. Liquid is added to or removed from the cavities C through the sample dispensing port C. The cavities C are respectively used to contain any one of staining reagents, biochemical detection reagents, or immunoassay reagents.
[0067] like Figures 5 to 6 An embodiment of a formed element detection and containment device, wherein the cavity heights of cavities B, C, and E are consistent.
[0068] like Figure 1 and Figure 2 A detection device is provided for use in conjunction with a formed element detection and containment device. It includes a microscopic magnification digital imaging component and a layer detection component. The microscopic magnification digital imaging component is used to capture magnified microscopic images of the microscopically examined sample, obtaining an image of the sample in cavity A for formed element analysis. The layer detection component is used to obtain layer information of sample E. The layer detection component includes a camera device that acquires a photograph of sample E and obtains layer information of sample E through the photograph.
[0069] like Figure 3 and Figure 4 A detection device is provided in which light from an optical detection component illuminates a sample in cavity B of an external multifunctional detection device, and biochemical or immunological analysis of the sample is performed based on the optical reaction characteristics of the sample. The optical detection component includes a light source and a light detection component. The light source illuminates the cavity B, and the light detection component acquires the light passing through the cavity B to obtain information on the optical reaction characteristics of the sample.
[0070] While this application has been described and illustrated with reference to preferred embodiments and several alternatives, it is not intended to be limited to the specific descriptions herein. Other alternatives or equivalent components may also be used to practice this application.
Claims
1. A formed element detection and containment device, characterized in that, Including Testing Department A and Testing Department E; The detection unit A includes a cavity A, which is used to contain sample A and to take a magnified microscopic image of the microscopic sample. The magnified microscopic image is used for formed element analysis. The detection unit E includes a cavity E; the cavity E is used to contain the sample E for static stratification. The stratification information of sample E is used to calculate the volume of the components in the formed elements.
2. The formed element detection and containing device according to claim 1, characterized in that, The detection unit E also includes a sample dispensing port E; the cavity E is connected to the sample dispensing port E; The detection unit A also includes a sample dispensing port A; the cavity A is connected to the sample dispensing port A.
3. The formed element detection and containing device according to claim 1, characterized in that, It also includes a detection unit B, which includes a cavity B and a sample dispensing port B, and the cavity B and the sample dispensing port B are connected. Cavity B is used to contain sample B and is used for optical detection and analysis of the sample. The optical detection and analysis is used for biochemical detection and analysis or immunoassay analysis of sample B.
4. The formed element detection and containing device according to claim 1, characterized in that, Includes any one of the following technical features: TA 10: Cavity A is used for formed element analysis; the formed element analysis includes any one or more of morphological analysis, biochemical analysis, and immunoassay analysis; TA20: The cross-section of the sample inlet E is larger than the cross-section of the cavity E; TA30: The sample is blood, and the stratification information is used to detect the hematocrit of the blood.
5. The formed element detection and containing device according to claim 1, characterized in that, The detection unit A also includes a sample addition chamber A, a sample addition port A, an exhaust chamber A, and an exhaust port A. The bottom of the sample addition chamber A is connected to the chamber A, and the sample addition port A is connected to the sample addition chamber A. The bottom of the exhaust chamber A is connected to the chamber A, and the exhaust port A is connected to the exhaust chamber A; The center of sample loading chamber A is higher than the center of chamber A. The center position of exhaust chamber A is higher than the center position of chamber A.
6. The formed element detection and containing device according to claim 1, characterized in that, It also includes a detection unit C, which includes at least one cavity C and a sample dispensing port C. The cavity C is used to contain the detection reagent, and the sample dispensing port C is open upward. Liquid is added to or removed from the cavity C through the sample dispensing port C. The cavity C is used to contain any one of staining reagents, biochemical detection reagents, or immunoassay reagents.
7. The formed element detection and containing device according to claim 1, characterized in that, Cavity B, cavity C, and cavity E have the same height.
8. A detection device, characterized in that, For use in conjunction with the formed element detection and containment device according to any one of claims 1 to 7; Includes microscopic magnification digital imaging components and layer detection components; The digital imaging component for microscopic magnification is used to capture magnified images of microscopically examined samples; it also obtains images of the samples in cavity A for formed element analysis. The stratification detection component is used to obtain stratification information for sample E.
9. The detection device according to claim 8, characterized in that, The layer detection component includes a camera device that acquires a photograph of sample E and obtains layer information of sample E through the photograph.
10. The detection device according to claim 8, characterized in that, It also includes optical detection components; The sample in cavity B of the external multifunctional detection device is illuminated by light in the optical detection component, and biochemical detection analysis or immunoassay analysis of the sample is performed based on the optical reaction characteristics of the sample. The optical detection component includes a light source and a light detection component; the light source illuminates the cavity B, and the light detection component acquires the light passing through the cavity B to obtain the optical reaction characteristics information of the sample.