Medicine filling and sealing equipment

Abstract

The utility model discloses medicine filling and sealing equipment which is provided with a main machine box for closed sterilization treatment, an ampoule sterilization drying oven, a bottle feeding mesh belt, an ampoule bottle conveying belt and a bottle discharging mesh belt are sequentially arranged in the main machine box, and an input auger component is arranged between the bottle feeding mesh belt and the head end of the ampoule bottle conveying belt. An output auger component is arranged between the tail end of the ampoule bottle conveying belt and the bottle outlet mesh belt, and a front nitrogen charging device, a liquid filling device, a rear nitrogen charging device, an ampoule bottle preheating device and an ampoule bottle wire drawing and sealing device are sequentially arranged above the ampoule bottle conveying belt along the line; sterile latex gloves corresponding to the bottle feeding mesh belt, the front nitrogen charging device, the liquid filling device, the rear nitrogen charging device, the ampoule bottle wire drawing and sealing device and the output auger component are arranged on the front and rear side walls of the main case; high-purity clean nitrogen is filled into the ampoule bottle before and after a liquid medicine filling procedure is carried out, air in the ampoule bottle is emptied, and various filling process requirements can be met.

Description

Technical Field

[0001] The utility model relates to the technical field of medicine filling production equipment, in particular to medicine filling equipment. Background Art

[0002] In the field of pharmaceutical filling and sealing, especially for the filling and sealing of ampoule bottles of liquid medicine, ampoule filling and sealing machines are very commonly used. Currently, many filling and sealing machines used in the market adopt melting sealing technology, and many machines even adopt post-nitrogen filling technology, resulting in insufficient qualified products. The shortcomings / deficiencies of existing technologies are as follows:

[0003] 1. The filling accuracy is not high, and the filling volume fluctuates greatly, about ±3%;

[0004] 2. The sealing effect is average, and the number of defective products such as bubble heads is high;

[0005] 3. Some manufacturers on the market use Class B laminar flow, and if the product filling time is long, there is a risk of microbial contamination;

[0006] 4. Some companies' workshops can only use the post-filling nitrogen method, which makes it difficult to achieve true vacuum treatment above the liquid in the ampoule, affecting the quality and pass rate of the product. Utility Model Content

[0007] The purpose of the present invention is to provide a medicine filling device in view of the above situation. The medicine filling device adopts a fully enclosed operation and has a better effect on the medicine liquid filling of ampoule bottles.

[0008] The specific scheme of the utility model is: a medicine filling equipment, with a closed sterilization treatment main box, the main box is arranged in sequence with an ampoule sterilization oven, a bottle feeding mesh belt, an ampoule bottle conveyor belt and a bottle discharging mesh belt, an input auger component is provided between the bottle feeding mesh belt and the head end of the ampoule bottle conveyor belt, an output auger component is provided between the tail end of the ampoule bottle conveyor belt and the bottle discharging mesh belt, and a front nitrogen filling device, a liquid filling device, a rear nitrogen filling device and a liquid filling device are provided above the ampoule bottle conveyor belt along the line. The number of ampoules corresponding to the device, ampoule preheating device and ampoule wire drawing and sealing device when the front nitrogen filling device, liquid filling device, rear nitrogen filling device, ampoule preheating device and ampoule wire drawing and sealing device are in operation remains consistent; sterile latex gloves are provided on the front and rear side walls of the main box corresponding to the bottle feeding mesh belt, front nitrogen filling device, liquid filling device, rear nitrogen filling device, ampoule wire drawing and sealing device and output auger components, and the sterile latex gloves are inserted into the main box from the outside to the inside.

[0009] Furthermore, the bottle feeding mesh belt in the present invention is further provided with an arc-shaped guide plate, which guides the ampoule bottles conveyed from the ampoule sterilization oven to the input auger component.

[0010] Furthermore, the input auger component in the present invention includes an input auger and an ampoule feeding wheel, and the ampoule feeding wheel is connected to the input auger and the ampoule conveyor belt.

[0011] Furthermore, the front nitrogen filling device and the rear nitrogen filling device described in the utility model have the same structure, and each includes a first lifting T-shaped head, and a plurality of nitrogen filling nozzles are evenly arranged downward on the first lifting T-shaped head. The nitrogen filling nozzles are arranged facing the ampoule bottle conveyor belt below. Each nitrogen filling nozzle is connected to the nitrogen air pump through a separate nitrogen air pipe, and the nitrogen air pipe is constrained and placed by a bracket.

[0012] Furthermore, the filling device described in the utility model includes a second lifting T-shaped head, and a plurality of filling nozzles are evenly arranged downward on the second lifting T-shaped head. The filling nozzles are arranged facing the ampoule bottle conveyor belt below. Each filling nozzle is connected to a separate ceramic pump through a separate liquid medicine delivery tube, and the liquid medicine delivery tube is constrained and placed by a bracket.

[0013] Furthermore, the ampoule preheating device of the present invention includes a plurality of preheating flame nozzles, which are arranged in a row and horizontally, and are arranged toward the ampoule conveyor belt.

[0014] Furthermore, the ampoule bottle wire drawing and sealing device described in the utility model includes a plurality of flame burners arranged side by side, all of which are arranged horizontally in a row, and are arranged horizontally, and the flame burners are arranged toward the ampoule bottle conveyor belt. A wire drawing and sealing clamp is provided corresponding to each flame burner, and the wire drawing and sealing clamp can be raised and lowered.

[0015] Furthermore, the output auger component in the present invention includes an output auger and an ampoule discharge wheel.

[0016] Furthermore, the main box of the present invention is also provided with a number of detection points for the content of floating bacteria and settling bacteria.

[0017] The filling and sealing machine equipment of the utility model has a filling accuracy of up to about ±1%, the filling volume fluctuation is extremely small, and the product stability is high; the wire drawing height of the ampoule bottle in the utility model is consistent, the product sealing effect is good, and the defective rate of bubble heads and pointed heads is reduced; in the utility model, high-purity clean nitrogen is filled into the ampoule bottle before and after the liquid medicine filling procedure, and the air in the ampoule bottle is evacuated, which can meet various filling process requirements. At the same time, a Class A laminar flow hood is used to achieve a sterile protection level and ensure product quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a schematic diagram of the main viewing direction structure of the utility model;

[0019] Figure 2 This is a schematic diagram of the structure of the utility model from a top view (with the cover open);

[0020] Figure 3 It is a schematic diagram of the structure of the utility model in a side view direction.

[0021] In the figure: 1—main chassis, 2—chassis door, 3—sterile latex gloves, 4—ampule sterilization oven, 5—arc-shaped guide plate, 6—ampule conveyor belt, 7—bracket, 8—ceramic pump, 9—preheating flame nozzle, 10—drawing sealing pliers, 11—output auger component, 12—bottle output mesh belt, 13—flame burner, 14—post-nitrogen filling device, 15—plankton content detection point, 16—liquid filling device, 17—front nitrogen filling device, 18—ampule feeding wheel, 19—input auger, 20—bottle input mesh belt. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings of the present invention to clearly and completely describe the technical solution of the present invention. It is obvious that the embodiments described are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work belong to the protection scope of the present invention. In the description of the present invention, it should be noted that the terms "upper", "lower", "inside", "outside" and the like indicate directions or positional relationships based on the directions or positional relationships shown in the drawings, or the directions or positional relationships in which the utility model product is usually placed when in use. They are only for the convenience of describing the present invention or simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed or operated in a specific direction, and therefore cannot be understood as a limitation on the present invention.

[0023] It should also be noted that, in the description of this utility model, unless otherwise expressly specified or limited, the terms "disposed," "installed," and "connected" should be understood in a broad sense. For example, they may refer to fixed connections, detachable connections, or integral connections; mechanical connections or electrical connections; direct connections or indirect connections through an intermediate medium; and internal communication between two components. Those skilled in the art will understand the specific meanings of these terms in this utility model based on the specific circumstances.

[0024] See also Figures 1 to 3The utility model is a drug filling and sealing device, which has a main box 1 for closed sterilization treatment, in which an ampoule sterilization oven 4, a bottle feeding mesh belt 20, an ampoule bottle conveyor belt 6 and a bottle discharging mesh belt 12 are arranged in sequence. An input auger component is provided between the bottle feeding mesh belt and the head end of the ampoule bottle conveyor belt, and an output auger component 11 is provided between the tail end of the ampoule bottle conveyor belt and the bottle discharging mesh belt. A front nitrogen filling device 17, a liquid filling device 16, a rear nitrogen filling device 17 and a liquid filling device 16 are provided above the ampoule bottle conveyor belt in sequence. The nitrogen filling device 14, the ampoule preheating device and the ampoule wire drawing and sealing device, the front nitrogen filling device, the liquid filling device, the rear nitrogen filling device, the ampoule preheating device and the ampoule wire drawing and sealing device correspond to the same number of ampoules when they are working; sterile latex gloves 3 are provided on the front and rear side walls of the main box corresponding to the bottle feeding mesh belt, the front nitrogen filling device, the liquid filling device, the rear nitrogen filling device, the ampoule wire drawing and sealing device and the output auger component, and the sterile latex gloves are inserted into the main box from the outside to the inside.

[0025] The ampoule bottle conveyor belt in this embodiment is servo-transmitted in the form of chain transmission, and the movement of the chain is precisely controlled by computer; a walking beam motion guide structure can also be adopted, which is a linear guide rail type, making the walking beam lighter and more flexible, and at the same time enhancing the rigidity.

[0026] Furthermore, the bottle feeding mesh belt in this embodiment is also provided with an arc-shaped guide plate 5, which guides the ampoules conveyed from the ampoule sterilization oven to the input auger component. The arc-shaped guide plate guides the dried ampoules to the input auger, and the input auger delivers them one by one to the ampoule feeding wheel. Furthermore, the input auger component in this utility model includes an input auger 19 and an ampoule feeding wheel 18, and the ampoule feeding wheel is connected to the input auger and the ampoule conveyor belt; further, the output auger component in this utility model includes an output auger and an ampoule unloading wheel.

[0027] Furthermore, the front nitrogen filling device and the rear nitrogen filling device described in this embodiment have the same structure, each including a first lifting T-shaped head with a plurality of nitrogen filling nozzles evenly arranged downwardly, facing the ampoule conveyor belt below. Each nitrogen filling nozzle is connected to a nitrogen pump via a separate nitrogen air pipe, which is restrained and supported by a bracket. Furthermore, the liquid filling device described in this utility model includes a second lifting T-shaped head with a plurality of liquid filling nozzles evenly arranged downwardly, facing the ampoule conveyor belt below. Each liquid filling nozzle is connected to a separate ceramic pump 8 via a separate liquid medicine delivery tube, which is restrained and supported by a bracket 7.

[0028] Furthermore, the ampoule preheating device described in this embodiment includes a plurality of preheating flame nozzles 9, which are arranged in a horizontal row and horizontally, and are arranged toward the ampoule conveyor. Furthermore, the ampoule wire drawing and sealing device described in this utility model includes a plurality of flame burners 13 arranged side by side, all of which are arranged in a horizontal row and horizontally, and are arranged toward the ampoule conveyor. A wire drawing and sealing clamp 10 is provided corresponding to each flame burner, and the wire drawing and sealing clamp can be raised and lowered.

[0029] Furthermore, the main box described in this embodiment is also provided with several planktonic bacteria content detection points 15 and sedimentation bacteria content detection points, and other relevant standard detection points can also be set. The design of these detection points is mainly to ensure the colony environment inside the main box at all times and to ensure that the filled medicine is not contaminated by the environment.

[0030] The main chassis in this embodiment is in the form of a transparent chassis, which makes it convenient for operators outside the main chassis to observe the production situation inside at any time.

[0031] This machine adopts linear intermittent filling and sealing. The main operating steps are as follows:

[0032] Check whether the dried ampoules have covered the bottle feeding mesh belt, straighten the inverted bottles or take them away with tweezers (operate with sterile latex gloves), and start the relevant control motor of the bottle feeding mesh belt.

[0033] The drug extraction operation fills the filling pipeline with liquid medicine and evacuates the air in the tube.

[0034] Select the ignition button to ignite the preheating flame nozzles and flame burners, adjust the flow meter switch so that the flame is blue and straight, and the flames of each nozzle and burner are the same size.

[0035] Press the "Start / Stop" button to start the machine at the set speed. After feeding a few groups of bottles, press the "Auger Brake" button to stop feeding the bottles. Check the filling and drawing effects. After confirming that they meet the production requirements, press the "Auger Brake" button to feed the bottles and start production.

[0036] In this embodiment, 12-pin filling or 14-pin filling is adopted. Of course, other numbers can also be designed. The number of each nitrogen filling station, filling station, preheating station and wire drawing and sealing station can be kept consistent.

[0037] Equipment principle:

[0038] The ampoules from the tunnel sterilization dryer, i.e., the ampoule sterilization oven, enter the bottle feeding mesh belt through the connecting plate and move forward to the input auger component. The input auger organizes the chaotic ampoules into an orderly separated state and pushes the ampoules one by one to the right to the bottle feeding dial, i.e., the ampoule feeding wheel. The bottle feeding dial continuously delivers the ampoules to the ampoule conveyor belt. The ampoule conveyor belt converts the continuous motion of the ampoules into intermittent motion. The middle walking beam component sends the ampoules to the next station in a step-by-step manner. The ampoule conveyor belt is also provided with a bottle support component along the way for positioning at each stationary station. The five intermittent stations are: (1) front inflation station; (2) liquid filling station; (3) rear inflation station; (4) preheating station; (5) wire drawing and sealing station. Throughout the entire process, ampoules and liquid medicine are always under laminar flow protection with a cleanliness level of Class 100. The operation of the equipment can be centrally controlled through the operation screen.

[0039] The filling and sealing machine equipment of the utility model has a filling accuracy of up to about ±1%, the filling volume fluctuation is extremely small, and the product stability is high; the wire drawing height of the ampoule bottle in the utility model is consistent, the product sealing effect is good, and the defective rate of bubble heads and pointed heads is reduced; in the utility model, high-purity clean nitrogen is filled into the ampoule bottle before and after the liquid medicine filling procedure, and the air in the ampoule bottle is evacuated, which can meet various filling process requirements. At the same time, a Class A laminar flow hood is used to achieve a sterile protection level and ensure product quality.

Claims

1. A drug filling equipment with a sealed sterilized main box, characterized by: The main box is sequentially arranged with an ampoule sterilization oven, a bottle inlet mesh belt, an ampoule conveyor belt and a bottle outlet mesh belt; an input auger component is provided between the bottle inlet mesh belt and the head end of the ampoule conveyor belt, and an output auger component is provided between the tail end of the ampoule conveyor belt and the bottle outlet mesh belt; a front nitrogen filling device, a liquid filling device, a rear nitrogen filling device, an ampoule preheating device and an ampoule wire drawing and sealing device are sequentially provided above the ampoule conveyor belt along the line; the number of ampoules corresponding to the front nitrogen filling device, the liquid filling device, the rear nitrogen filling device, the ampoule preheating device and the ampoule wire drawing and sealing device when they are in operation is kept consistent; sterile latex gloves are provided on the front and rear side walls of the main box corresponding to the bottle inlet mesh belt, the front nitrogen filling device, the liquid filling device, the rear nitrogen filling device, the ampoule wire drawing and sealing device and the output auger component, and the sterile latex gloves are inserted into the main box from the outside to the inside.

2. The drug filling equipment according to claim 1, characterized in that: The bottle feeding mesh belt is further provided with an arc-shaped guide plate, which guides the ampoule bottles conveyed out of the ampoule sterilization oven to the input auger component.

3. The drug filling equipment according to claim 1, characterized in that: The input auger component comprises an input auger and an ampoule feeding wheel, and the ampoule feeding wheel is connected to the input auger and the ampoule conveyor belt.

4. The drug filling equipment according to claim 1, characterized in that: The front nitrogen filling device and the rear nitrogen filling device have the same structure, and each includes a first lifting T-shaped head. A plurality of nitrogen filling nozzles are evenly arranged downward on the first lifting T-shaped head. The nitrogen filling nozzles are arranged facing the ampoule bottle conveyor belt below. Each nitrogen filling nozzle is connected to a nitrogen air pump through a separate nitrogen air pipe, and the nitrogen air pipe is constrained and placed by a bracket.

5. The drug filling equipment according to claim 1, characterized in that: The filling device includes a second lifting T-shaped head, on which a plurality of filling nozzles are evenly arranged downward, and the filling nozzles are arranged facing the ampoule bottle conveyor belt below. Each filling nozzle is connected to a separate ceramic pump through a separate liquid medicine delivery tube, and the liquid medicine delivery tube is constrained and placed by a bracket.

6. The drug filling equipment according to claim 1, characterized in that: The ampoule preheating device comprises a plurality of preheating flame nozzles, which are arranged in a row and horizontally, and are arranged toward the ampoule conveyor belt.

7. The drug filling equipment according to claim 1, characterized in that: The ampoule wire drawing and sealing device includes a plurality of flame burners arranged side by side. All the flame burners are arranged in a row and arranged horizontally. The flame burners are arranged toward the ampoule conveyor belt. A wire drawing and sealing clamp is provided corresponding to each flame burner, and the wire drawing and sealing clamp can be raised and lowered.

8. The drug filling equipment according to claim 1, characterized in that: The output auger component includes an output auger and an ampoule bottle unloading wheel.

9. The drug filling equipment according to claim 1, characterized in that: The main box is also provided with a number of detection points for the content of floating bacteria and settling bacteria.

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