A multifunctional detection platform

Abstract

The utility model relates to a kind of multifunctional detection platform, including work platform, and work platform includes heating oscillation module, dilution module, dilution module includes several dilution bins and peristaltic pump, sample port and constant-volume port are set on dilution bin, constant-volume port is located above sample port, magnetic stirrer is set below dilution bin, work platform includes several supporting table, and work platform upper includes clamping mechanism, multi-union variable-distance pipetting mechanism, detection module is set below work platform.The utility model is integrated with pipetting, culture, heating, oscillation, detection and the like multifunction, and usage mode is flexible, and application scene is various.

Description

Technical Field

[0001] This utility model relates to the field of multifunctional workstations, specifically a multifunctional testing platform. Background Technology

[0002] Pipetting workstations are highly automated devices designed specifically for laboratory liquid handling. Although they offer many advantages, such as increased efficiency and reduced manpower, some existing pipetting workstations on the market still have some problems. For example, common pipetting workstations usually perform single automated operations according to preset programs. While this greatly improves efficiency, the functional modes are fixed and lack flexibility. Utility Model Content

[0003] To address the aforementioned issues, this invention provides a multifunctional detection platform that integrates pipetting, heating, shaking, and detection functions, offering flexible usage and diverse application scenarios.

[0004] A multifunctional detection platform includes a frame, with a working platform located in the center of the frame. The working platform includes a heating and oscillation module and a dilution module. The dilution module includes several dilution chambers and a peristaltic pump. Each dilution chamber has an opening at the top and a sample delivery port and a volume adjustment port on its side. The sample delivery port is located at the bottom of the dilution chamber, and the volume adjustment port is located above the sample delivery port. A magnetic stirrer is located below the dilution chamber. The working platform includes several support platforms for placing one or more of the following: microplates, reagent bottles, EP tubes, and pipette tips. A clamping mechanism and a multi-stage variable-distance pipetting mechanism are located above the working platform. The clamping mechanism is connected to the frame, and the multi-stage variable-distance pipetting mechanism is connected to the frame. The detection module is located below the working platform.

[0005] Preferably, the clamping mechanism is a three-dimensional motion structure, including a first motion module, a second motion module and a third motion module. The first motion module is connected to the frame, the second motion module is disposed on the first motion module, and the third motion module is disposed on the second motion module.

[0006] Preferably, a rack, a slide rail, and a guide rail are arranged in parallel on the upper part of the frame. The rack and the slide rail are arranged on the same side of the frame, and the guide rail is arranged on the other side. The first motion module includes a first motor, a gear, a slider, and a roller. The gear meshes with the rack, the slider is slidably connected to the slide rail, and the roller is tumbledly connected to the guide rail. The first motor is connected to the gear and drives the gear to rotate.

[0007] Preferably, the first motion module includes a slide rail and a rack, and the second motion module includes a support member. A slider, a gear, and a second motor are disposed on the support member. The gear and the rack mesh, the slider and the slide rail are slidably connected, and the second motor is connected to the gear and drives the gear to rotate.

[0008] Preferably, the third motion module includes a rack and a slide rail. A third motor, a gear, and a slider are mounted on the support. The gear meshes with the rack, the slider is connected to the slide rail, and the third motor is connected to the gear to drive it to rotate.

[0009] Preferably, a gripper is provided below the third motion module, the gripper being used to grasp and transfer the ELISA plate or reagent container.

[0010] Preferably, the dilution module includes a sample inlet tube, a waste outlet tube, and a first pipeline, wherein the first pipeline is connected to the sample delivery port, and the sample inlet tube, the waste outlet tube, and the first pipeline are connected by a T-junction.

[0011] Preferably, the constant volume port is connected to a second pipeline for discharging liquid exceeding the constant volume port.

[0012] Preferably, the detection module is an enzyme-linked immunosorbent assay (ELISA) reader.

[0013] Preferably, the system includes a control system, which is communicatively connected to the heating and oscillation module, the dilution module, the clamping mechanism, the multi-stage variable-pipette mechanism, and the detection module.

[0014] This utility model provides a multifunctional detection platform that integrates functions such as pipetting, dilution, heating and shaking, and detection into a single unit through a highly integrated design, significantly improving detection efficiency and ease of operation. It employs a three-axis linkage precision clamping mechanism and a multi-stage variable-pitch pipetting mechanism, coupled with an independently controlled peristaltic pump and magnetic stirring system, achieving automation and precise control of the entire sample processing process. The unique dilution module design ensures dilution accuracy through a volume control port and an independent tubing system, while the modular work platform layout can accommodate different specifications of experimental consumables. The control system's collaborative management of each functional module not only simplifies the operation process but also supports the programming settings of personalized experimental schemes. This platform effectively solves the problems of traditional detection equipment being single-function and cumbersome to operate, significantly increasing detection throughput while ensuring detection accuracy, and can be widely used in fields such as biomedicine. Attached Figure Description

[0015] The above and / or additional aspects and advantages of this invention will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0016] Figure 1This is a schematic diagram of the overall structure of an embodiment of this utility model;

[0017] Figure 2 This is a schematic diagram of the structure of an embodiment of the present utility model;

[0018] Figure 3 This is a schematic diagram of the structure of an embodiment of the present utility model;

[0019] Figure 4 This is a schematic diagram of the structure of an embodiment of the present utility model;

[0020] Figure 5 This is a schematic diagram of the third motion module structure according to an embodiment of this utility model;

[0021] Figure 6 This is a schematic diagram of the dilution module structure according to an embodiment of the present invention;

[0022] Figure 7 This is a schematic diagram of the dilution chamber structure according to an embodiment of this utility model.

[0023] In the diagram: 1. Frame; 2. Working platform; 3. Heating and oscillation module; 4. Dilution module; 5. Dilution chamber; 6. Sample inlet; 7. Volume control inlet; 8. Magnetic stirrer; 9. Support platform; 10. Clamping mechanism; 11. Multi-stage variable-pitch pipetting mechanism; 12. Detection module; 13. First motion module; 14. Second motion module; 15. Third motion module; 16. Rack 1; 17. Slide rail 1; 18. Guide rail; 19. First motor; 20. Gear 1; 21. Slider 1; 22. Roller; 23. Slide rail 2; 24. Rack 2; 25. Support component; 26. Slider 2; 27. Gear 2; 28. Second motor; 29. ​​Rack 3; 30. Slide rail 3; 31. Gear 3; 32. Slider 3; 33. Third motor; 34. Gripper; 35. Sample inlet tube; 36. Waste discharge tube; 37. First pipeline; 38. Second pipeline; 39. Peristaltic pump; 40. Three-way valve. Detailed Implementation

[0024] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0025] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0026] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection, an electrical connection, or a connection that allows for communication; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0027] The following disclosure provides many different embodiments or examples for implementing various structures of this invention. To simplify the disclosure, specific examples of components and arrangements are described below. Of course, these are merely examples and are not intended to limit the scope of this invention.

[0028] See Figure 1-7 The present invention provides a multifunctional detection platform, including a cuboid with a working platform 2 in the middle. The working platform 2 includes a heating and oscillation module 3 and a dilution module 4, and a detection module 12 is arranged below the working platform 2.

[0029] like Figure 6-7 As shown, the dilution module 4 includes several dilution chambers 5 and a peristaltic pump 39. The dilution chambers 5 have openings at the top for the multi-stage variable-pitch pipetting mechanism 11 to inject samples into them. Each dilution chamber 5 has a sample inlet 6 and a volume-fixing port 7 on its side. The sample inlet 6 is located at the bottom of the dilution chamber 5, and the volume-fixing port 7 is located above the sample inlet 6. Water or other solutions are introduced into the dilution chamber 5 through the sample inlet 6 to dilute it by a certain factor. Liquid exceeding the volume-fixing port 7 is aspirated and discharged.

[0030] A magnetic stirrer 8 is installed below the dilution chamber 5 to stir and mix the solution in the dilution chamber 5.

[0031] like Figure 7As shown, the dilution module 4 includes a sample inlet tube 35, a waste outlet tube 36, and a first pipeline 37. The first pipeline 37 is connected to the sample delivery port 6. The sample inlet tube 35, the waste outlet tube 36, and the first pipeline 37 are connected by a three-way valve. A second pipeline 38 is connected to the volume control port 7.

[0032] Furthermore, each dilution chamber 5 is equipped with three peristaltic pumps 39, which are respectively connected to the sample inlet tube 35, the waste outlet tube 36, and the second pipeline 38.

[0033] Specifically, the on / off state of each pipeline is controlled by a three-way valve, and the peristaltic pump 39 is used to realize the functions of liquid inlet, waste liquid outlet, and volume control.

[0034] See Figure 1 The working platform 2 includes several support platforms 9, which can be used to place items such as ELISA plates, reagent bottles, EP tubes, and pipette tips.

[0035] The upper part of the working platform 2 includes a clamping mechanism 10 and a multi-stage variable-pitch pipetting mechanism 11.

[0036] Specifically, the clamping mechanism 10 is a three-dimensional motion structure used to clamp and transfer the ELISA plate, and the multi-stage variable-pipette mechanism 11 is connected to the sliding mechanism, which can automatically change the pipette tip to complete the liquid transfer.

[0037] Furthermore, the clamping mechanism 10 includes a first motion module 13, a second motion module 14, and a third motion module 15. The first motion module 13 is connected to the first motion module 13 and can move along its length. The second motion module 14 is disposed on the first motion module 13, and the third motion module 15 is disposed on the second motion module 14. A gripper 34 is connected below the third motion module 15. The gripper 34 can be an electric gripper or can be driven by pneumatic, hydraulic, or other power sources.

[0038] In some embodiments, a rack 16, a slide rail 17, and a guide rail 18 are arranged in parallel on the upper part. The rack 16 and the slide rail 17 are located on the same side, and the guide rail 18 is located on the other side. The first motion module 13 includes a first motor 19, a gear 20, a slider 21, and a roller 22. The gear 20 meshes with the rack 16, the slider 21 is slidably connected to the slide rail 17, and the roller 22 is rotatably connected to the guide rail 18. The first motor 19 is connected to the gear 20 and drives the gear 20 to rotate.

[0039] Furthermore, the first motion module 13 also includes a slide rail 23 and a rack 24, and the second motion module 14 includes a support member 25, which is a square structure. A slider 26, a gear 27, and a second motor 28 are provided on the support member 25. The gear 27 and the rack 24 mesh, and the slider 26 is connected to the slide rail 23. The second motor 28 drives the gear 27, thereby causing the second motion module 14 to move along the rack 24.

[0040] Furthermore, the third motion module 15 includes a rack 3 29 and a slide rail 30. A gear 3 31, a third motor 33 and a slider 3 32 are connected to the support member 25. The gear 3 31 and the rack 3 29 mesh, and the slider 3 32 and the slide rail 3 30 are slidably connected. The third motor 33 is used to drive the gear 3 31 to rotate and move along the rack 3 29.

[0041] Furthermore, a gripper 34 is provided below the third motion module 15.

[0042] Thus, the first motion module 13, the second motion module 14, and the third motion module 15, through the coordinated action of components such as slide rails, sliders, gears, racks, and motors, can achieve precise motion control along the three-dimensional spatial direction, driving the gripper 34 to move and pick up and put in the enzyme label plate.

[0043] In some specific implementations, the detection module 12 integrates an enzyme-linked immunosorbent assay (ELISA) reader, which is located below the working platform 2. The ELISA plate is fed into the ELISA reader through the clamping mechanism 10, and the ELISA reader can automatically complete the detection.

[0044] In some specific embodiments, the clamping mechanism 10 transfers the enzyme-labeled plate to the heating and oscillation module 3, which shakes and heats the solution in the enzyme-labeled plate to ensure the uniformity of reagent addition and reaction.

[0045] Preferably, the multi-functional testing platform includes a control system, which is communicatively connected to the heating and oscillation module 3, the dilution module 4, the clamping mechanism 10, the multi-stage variable-pitch pipetting mechanism 11, and the testing module 12. The control system is used to control the operation of each module and collect relevant operation and testing data.

[0046] Example

[0047] In an exemplary embodiment, when an operator uses a calcium ion reagent kit to test a sample, the control system is set to first take 20 μL of sample and 100 μL of reagent A, shake to mix, react at 37°C for 10 minutes, then add 100 μL of reagent B, shake to mix, react at 37°C for 10 minutes, and finally perform the test.

[0048] After setup, first, reagents A and B are placed into reagent bottles, and the sample is placed into an EP tube. After placing the reagent bottles and EP tube in the designated positions, the multi-functional detection platform is started to begin automated operation. First, the multi-stage variable-distance pipetting mechanism 11 draws 20 μL of sample and 100 μL of reagent A and injects them into the ELISA plate. The clamping mechanism 10 then transfers the ELISA plate containing the sample to the heating and shaking module 3, where it is shaken for a certain period to mix, and reacted at 37°C for 10 minutes. Next, the clamping mechanism 10 transfers the ELISA plate to the support stage 9. The multi-stage variable-distance pipetting mechanism 11 draws 100 μL of reagent B and injects it into the sample that has reacted with reagent A. The clamping mechanism 10 then transfers the ELISA plate to the heating and shaking module 3, where it is shaken for a certain period to mix, and reacted at 37°C for 10 minutes. Finally, the clamping mechanism 10 transfers the ELISA plate to the ELISA reader, which detects the absorbance value and outputs the data.

[0049] Although embodiments of the present invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A multifunctional testing platform, characterized in that, The device includes a frame, with a working platform in the center of the frame. The working platform includes a heating and oscillation module and a dilution module. The dilution module includes several dilution chambers and a peristaltic pump. The dilution chambers have an opening at the top and a sample delivery port and a volume adjustment port on the side. The sample delivery port is at the bottom of the dilution chamber, and the volume adjustment port is above the sample delivery port. A magnetic stirrer is located below the dilution chamber. The working platform includes several support platforms for placing one or more of the following: microplates, reagent bottles, EP tubes, and pipette tips. A clamping mechanism and a multi-stage variable-distance pipetting mechanism are located above the working platform. The clamping mechanism is connected to the frame, and the multi-stage variable-distance pipetting mechanism is connected to the frame. A detection module is located below the working platform.

2. The multifunctional detection platform according to claim 1, characterized in that, The clamping mechanism is a three-dimensional motion structure, including a first motion module, a second motion module and a third motion module. The first motion module is connected to the frame, the second motion module is disposed on the first motion module, and the third motion module is disposed on the second motion module.

3. The multifunctional detection platform according to claim 2, characterized in that, The upper part of the frame is provided with a rack, a slide rail, and a guide rail arranged in parallel. The rack and the slide rail are located on the same side of the frame, and the guide rail is located on the other side. The first motion module includes a first motor, a gear, a slider, and a roller. The gear meshes with the rack, the slider is slidably connected to the slide rail, and the roller is tumbledly connected to the guide rail. The first motor is connected to the gear and drives the gear to rotate.

4. The multifunctional detection platform according to claim 3, characterized in that, The first motion module includes a slide rail and a rack. The second motion module includes a support member. A slider, a gear, and a second motor are mounted on the support member. The gear and the rack mesh. The slider and the slide rail are slidably connected. The second motor is connected to the gear and drives the gear to rotate.

5. A multifunctional detection platform according to claim 4, characterized in that, The third motion module includes a rack and a slide rail. A third motor, a gear, and a slider are mounted on the support. The gear meshes with the rack, the slider is connected to the slide rail, and the third motor is connected to the gear to drive it to rotate.

6. A multifunctional detection platform according to claim 5, characterized in that, The third motion module is equipped with grippers below it, which are used to grasp and transfer ELISA plates or reagent containers.

7. A multifunctional detection platform according to claim 1, characterized in that, The dilution module includes a sample inlet tube, a waste outlet tube, and a first pipeline. The first pipeline is connected to the sample delivery port, and the sample inlet tube, waste outlet tube, and first pipeline are connected by a three-way valve.

8. A multifunctional detection platform according to claim 1, characterized in that, The fixed-volume port is connected to a second pipeline for discharging liquid exceeding the fixed-volume port.

9. A multifunctional detection platform according to claim 1, characterized in that, The detection module is an enzyme-linked immunosorbent assay (ELISA) reader.

10. A multifunctional detection platform according to claim 1, characterized in that, The system includes a control system, which is communicatively connected to the heating and oscillation module, the dilution module, the clamping mechanism, the multi-stage variable-pipette mechanism, and the detection module.

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