DUAL-SPECIFIC ANTIBODY CONSTRUCTS FOR CDH3 AND CD3

Abstract

The present invention relates to a bispecific antibody construct comprising a first human binding domain that binds to human CDH3 on the surface of a target cell and a second binding domain that binds to human CDS on the surface of a T cell. Furthermore, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a diagnostic kit comprising said antibody construct.