Immolative cell-penetrating complexes for nucleic acid delivery to the lungs

DE602020073134T2Active Publication Date: 2026-06-10THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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Patent Information

Application Number
DE602020073134
Authority / Receiving Office
DE · DE
Patent Type
Patents
Current Assignee / Owner
Priority Date
2019-02-01
Filing Date
2020-01-31
Publication Date
2026-06-10
Estimated Expiration
2040-01-31

AI Technical Summary

Technical Problem

There is a need for improved materials and strategies to deliver therapeutic agents, diagnostic probes, and research tools across cellular membranes and biological barriers for clinical, diagnostic, and research applications, particularly for nucleic acid delivery in contexts such as vaccination, cancer immunotherapy, and gene editing.

Method used

Development of cationic amphipathic polymers and cell-penetrating complexes that non-covalently bind nucleic acids, featuring pH-sensitive immolation domains and lipophilic polymer domains, to facilitate efficient delivery across cellular membranes.

Benefits of technology

The complexes effectively deliver nucleic acids into cells, including reticulocytes and hematopoietic stem cells, and induce immune responses, offering therapeutic potential for various diseases and conditions.

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