New peptides and use thereof

EP4758157A1Pending Publication Date: 2026-06-17MAJEWSKI FILIP
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Patent Information

Application Number
EP2023772342
Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2023-08-13
Publication Date
2026-06-17

AI Technical Summary

Technical Problem

Existing peptides face challenges with physicochemical stability and bioavailability, particularly in normal saline, which limits their therapeutic effectiveness.

Method used

The simultaneous addition of arginine amide at the C-terminus and acetylation of the N-terminus in peptide derivatives, such as Ac-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-Arg-NH2, enhances stability and biological activity.

Benefits of technology

This modification significantly improves the stability and biological activity of the peptides, addressing the limitations of existing peptide therapies.

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Abstract

A subject matter of the invention are new peptides and their use as dietary supplement. Compound selected from the group consisting of Ac-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala- Asp-Asp-Ala-Gly-Leu-Val-Arg-NH2 (SEQ. ID 1); Ac-Ala-Glu-Asp-Gly-Arg-NH2 (SEQ. ID 2); Ac-Gly-His-Lys-Arg-NH2 (SEQ. ID 3); Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Arg-NH2 (SEQ. ID 4), Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-Arg-NH2 (SEQ. ID 5), and Ac-Ala-Glu-Asp-Pro-Arg-NH2 (SEQ. ID 6), or its pharmaceutically acceptable salt or complex. A subject matter of the invention is also a dietary supplement composition comprising compound mentioned above and its use as a dietary supplement.
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