Hair-penetrating and / or hair-coating emulsion composition

Abstract

To provide a hair-penetrating and / or hair-coating emulsion composition that prevents disruption of emulsion particles even when adsorbed onto the cuticle, allows for the efficient penetration of numerous active components into the hair cortex, and applies a protective coating over the hair surface.SOLUTION: The present invention provides a hair-penetrating and / or a hair-coating emulsion composition, containing an oil phase, an aqueous phase, and nanoparticles. The nanoparticles are either closed vesicles formed by an amphiphilic substance that spontaneously forms the closed vesicles or particles of condensation polymers with hydroxyl groups.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a hair-penetrating and / or hair-coating emulsion composition. [Background technology]

[0002] The reality is that modern women's hair is subject to physical stresses such as daily shampooing, hair drying, and ultraviolet rays, chemical stresses from frequent use of hair coloring and perm products, and nowadays, a lot of mental stress as well. These stresses have a great impact on each part of the hair, such as the hair shaft, scalp, and hair root, causing structural changes and destruction of cells, intercellular lipids, cell membrane complexes (CMC), etc., resulting in a decrease in functionality, and as a result, many hair damage phenomena have been observed to date, such as lack of smoothness, lack of shine, lack of strength, lack of elasticity, lack of firmness, dryness, split ends and breakage, thinning, curly hair, and a decrease in the number of hairs.

[0003] To address these issues, various studies have been conducted, such as those in Patent Documents 1 and 2, but the hair shaft, especially the cortex, which accounts for 85% of the hair shaft, requires repair with a large amount of repair components, and so there has been insufficient research into this issue, including the technical aspects. As a result, damage to the cortex has yet to be fully resolved.

[0004] When the cortex is stressed, the CMC of the intercellular lipids changes in structure or is destroyed, causing it to be washed away, and along with this loss of the natural moisturizing factors (NMF), moisture, and peptides that are the moisturizing components within the cells, the fibrous crystalline proteins and non-crystalline proteins in the cell body are denatured and destroyed, resulting in the loss of moisture, elasticity, body, thickness, hardness, and firmness of hair. To prevent this phenomenon and maintain beautiful hair, it is necessary to reliably deliver large amounts of active ingredients to the cortex and thoroughly repair and improve the CMC and cells.

[0005] For this purpose, a vehicle that can carry a large amount of active ingredients is important, and emulsions are optimal, rather than molecular assemblies such as vesicles, hexosomes, or cubosomes. However, emulsions obtained by conventional molecular emulsification are easily destroyed when adsorbed to the cuticle, making it difficult to deliver active ingredients to the cortex. Therefore, there is a need to create a carrier emulsion that is less likely to be destroyed by adsorption to hair and can deliver large amounts of active ingredients to the cortex.

[0006] In addition, Patent Document 3 describes an external preparation for hair growth in which closed vesicles formed by an amphiphilic substance that spontaneously forms closed vesicles or polycondensation polymer particles having hydroxyl groups are dispersed in water. However, Patent Document 3 is an invention related to a hair growth technology that acts on hair roots, and does not consider hair. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] JP 2023-010657 A [Patent Document 2] JP 2021-172621 A [Patent Document 3] JP 2014-125480 A Summary of the Invention [Problem to be solved by the invention]

[0008] The object of the present invention is to provide a hair-penetrating and / or hair-coating emulsion composition which is less likely to destroy emulsion particles even when adsorbed to the cuticle, can efficiently penetrate many active ingredients into the cortex, and can coat and protect the hair surface. [Means for solving the problem]

[0009] [1] A hair-penetrating and / or hair-coating emulsion composition comprising an oil phase, an aqueous phase, and nanoparticles, the nanoparticles being at least one of closed vesicles formed by an amphiphilic substance that spontaneously forms closed vesicles and particles of a polycondensation polymer having hydroxyl groups. [2] The hair penetration and / or hair coating emulsion composition according to the above item [1], which is an O / W type emulsion. [3] The hair-penetrating and / or hair-coating emulsion composition according to [1] or [2] above, wherein the nanoparticles are present at the interface between the oil phase and the aqueous phase. [4] The hair-penetrating and / or hair-coating emulsion composition according to any one of the above [1] to [3], wherein the nanoparticles have affinity for cortex cells. [5] The hair-penetrating and / or hair-coating emulsion composition according to any one of the above [1] to [4], wherein the nanoparticles contain at least one of a ceramide and a sterol. [6] The hair-penetrating and / or hair-coating emulsion composition according to any one of the above [1] to [5], wherein the nanoparticles comprise an unsaturated fatty acid, a basic amino acid, and at least one of a ceramide and a sterol. [7] The hair-penetrating and / or hair-coating emulsion composition according to [6] above, wherein the unsaturated fatty acid is a monounsaturated fatty acid or a polyunsaturated fatty acid. [8] The hair-penetrating and / or hair-coating emulsion composition according to [6] or [7] above, wherein the basic amino acid is at least one of lysine and L-arginine. [9] The hair-penetrating and / or hair-coating emulsion composition according to any one of the above [6] to [8], wherein the ceramide is one or more types selected from the group consisting of human ceramide, plant ceramide, and pseudo-ceramide.

[10] The hair-penetrating and / or hair-coating emulsion composition according to any one of the above [6] to [8], wherein the sterol is at least one of cholesterol and phytosterol.

[11] The hair-penetrating and / or hair-coating emulsion composition according to any one of the above [1] to [4], wherein the nanoparticles comprise phytantriol and sodium dilauroyl glutamate lysine.

[12] The hair-penetrating and / or hair-coating emulsion composition according to any one of the above [1] to [4], wherein the nanoparticles comprise hydrophobized hydroxypropyl methylcellulose. Effect of the Invention

[0010] According to the present invention, it is possible to provide a hair-penetrating and / or hair-coating emulsion composition which is less likely to cause destruction of emulsion particles even when adsorbed to the cuticle, can efficiently penetrate many active ingredients into the cortex, and can coat and protect the hair surface. [Brief description of the drawings]

[0011] [Figure 1] FIG. 1 is an image of a cross section of a hair sample immersed in the emulsion composition of Example 1, observed with a fluorescence microscope. [Diagram 2] FIG. 2 is an image of a cross section of damaged hair that was immersed in water for 6 hours without being immersed in the emulsion composition of Example 1, observed under a fluorescent microscope. [Diagram 3] FIG. 3 is an image of a cross section of a hair sample immersed in the emulsion composition of Comparative Example 1, observed under a fluorescent microscope. [Figure 4] FIG. 4 is an image of the cross section of a hair sample immersed in the emulsion composition of Example 2, observed under a fluorescent microscope. [Diagram 5] FIG. 5 is an image of a cross section of a hair sample immersed in the emulsion composition of Example 3, observed with a fluorescence microscope. [Figure 6] FIG. 6 is an image of the cross section of a hair sample immersed in the emulsion composition of Example 4, observed under a fluorescence microscope. [Figure 7] FIG. 7 is an image of the cross section of a hair sample immersed in the emulsion composition of Example 5, observed under a fluorescence microscope. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0012] Hereinafter, a detailed description will be given based on an embodiment.

[0013] The hair-penetrating and / or hair-coating emulsion composition of the embodiment comprises an oil phase, an aqueous phase, and nanoparticles, the nanoparticles being at least one of closed vesicles formed by an amphiphilic substance that spontaneously forms closed vesicles and particles of a polycondensation polymer having hydroxyl groups.

[0014] The hair-penetrating and / or hair-coating emulsion composition contains an oil phase, an aqueous phase, and nanoparticles, and is an O / W type emulsion. The nanoparticles are at least one of closed vesicles (hereinafter also simply referred to as closed vesicles) formed by an amphiphilic substance that spontaneously forms closed vesicles, and particles of polycondensation polymers having hydroxyl groups (hereinafter also simply referred to as polycondensation polymer particles). Such a hair-penetrating and / or hair-coating emulsion composition is an emulsion composition that applies a so-called three-phase emulsification method using at least one of closed vesicles and particles of polycondensation polymers, and is an O / W type (oil-in-water type) emulsion.

[0015] The closed vesicles have the property of spontaneously forming closed vesicles in an aqueous component. The polycondensation polymer particles include single particles of the polycondensation polymer and those in which single particles of the polycondensation polymer are linked together, but do not include aggregates (having a network structure) of the polycondensation polymer before being made into single particles.

[0016] In the hair-penetrating and / or hair-coating emulsion composition, at least one of a plurality of closed endoplasmic reticulum and a plurality of polycondensation polymer particles is present around the oil phase, which is the internal phase, and further outside the oil phase, which is the external phase, is the aqueous phase. That is, a plurality of nanoparticles are present at the interface between the oil phase and the aqueous phase, and the aqueous phase is the continuous phase. Thus, in the hair-penetrating and / or hair-coating emulsion composition, the oil phase is dispersed in the aqueous phase.

[0017] The hair-penetrating and / or hair-coating emulsion composition contains a large number of emulsion particles (three-phase emulsion particles) in which nanoparticles are present around a particulate oil phase that is larger than the nanoparticles. An aqueous phase is present around the emulsion particles, and a large number of the emulsion particles are dispersed in the aqueous phase.

[0018] Particles of closed vesicles and polycondensation polymers are known as particles having a so-called three-phase emulsifying ability, and nanoparticles are at least one of particles of closed vesicles and polycondensation polymers.

[0019] A large number of nanoparticles are present on the surface of the particulate oil phase, i.e., the surface of the oil phase is covered with a large number of nanoparticles, so that a repulsive force occurs between the oil phases. The repulsive force occurring between the oil phases is greater than the attractive force occurring between the oil phases. Therefore, the aggregation of the oil phases in the aqueous phase, i.e., the aggregation of the emulsified particles, is suppressed, and the dispersibility of the oil phase is maintained and improved.

[0020] In this three-phase emulsification method, nanoparticles adhere to the oil phase, which is the internal phase, by van der Waals forces, and are present at the interface between the oil phase (internal phase) and the water phase (external phase), enabling emulsification of the oil and water phases. The three-phase emulsification mechanism is completely different from the emulsification mechanism using surfactants, which maintains the emulsified state by directing the hydrophilic and hydrophobic parts toward the water and oil phases, respectively, and lowering the oil-water interfacial tension (see, for example, Japanese Patent Publication No. 3855203).

[0021] The nanoparticles may consist of only closed vesicles, or may consist of only polycondensation polymer particles, or may consist of both closed vesicles and polycondensation polymer particles.

[0022] As described above, the hair penetrating and / or hair-coating emulsion composition applies a three-phase emulsification technique that is completely different from the emulsification mechanism using a surfactant. Therefore, the hair penetrating and / or hair-coating emulsion composition can maintain a stable emulsified state even without containing a surfactant. Thus, the amount of surfactant can be significantly reduced in the hair penetrating and / or hair-coating emulsion composition compared to emulsion compositions using conventional surfactants, and in some cases, no surfactant is contained.

[0023] In addition, because the emulsion particles have a three-phase emulsion structure, emulsion particles containing nanoparticles are less likely to be destroyed even when adsorbed to the cuticle, and can efficiently penetrate many active ingredients into the cortex while also coating and protecting the hair surface.

[0024] The oil phase of the hair-penetrating and / or hair-coating emulsion composition is an oily component and is not mixed with the water phase. The oil phase may be a solid oil or a mixture of a solid oil and a liquid oil, but is preferably a liquid oil. A liquid oil is an oil that is liquid at room temperature (25° C.), and a solid oil is an oil that is solid at room temperature.

[0025] Liquid oils include vegetable oils (olive oil, avocado oil, camellia oil, macadamia nut oil, evening primrose oil, jojoba oil, rapeseed oil, egg yolk oil, sesame oil, castor oil, safflower oil, cottonseed oil, soybean oil, tea seed oil, rice bran oil, wheat germ oil, germ oil, peanut oil, sunflower oil, almond oil, turtle oil, corn oil, mink oil, persic oil, camellia oil, linseed oil, perilla oil, kaya oil, etc.), medium-chain fatty acid triglycerides, hydrocarbon oils (squalene, squalane, liquid paraffin, etc.), ester oils (ethylhexyl methoxycinnamate, cetyl ethylhexanoate, diisostearyl malate, isopropyl myristate, ethylhexyl palmitate, octyl palmitate, octyl isopalmitate, isononyl isononanoate, isotoyl isononanoate, Lidecyl, methylheptyl laurate, hexyl laurate, tri(caprylic acid / capric acid)glyceryl, triethylhexanoin, neopentyl glycol dicaprate, cetyl octanoate, isocetyl stearate, isopropyl isostearate, isodecyl oleate, glyceryl tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, 2-ethylhexyl succinate, diethyl sebacate, etc.), silicone oils (cyclopentasiloxane, decamethylcyclopentasiloxane, methylpolysiloxane, dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, dodecamethylcyclohexasiloxane, etc.).

[0026] Examples of solid oils include shea butter, coconut oil, petrolatum, beeswax, stearyl alcohol, cetanol, behenyl alcohol, phytosteryl macadamia nut oil fatty acid, dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), and hydrogenated castor oil isostearate.

[0027] The average particle size of the oil phase in the hair penetrating and / or hair coating emulsion composition is appropriately selected depending on the application of the hair penetrating and / or hair coating emulsion composition. The hair penetrating and / or hair coating emulsion composition is a three-phase emulsion, so the average particle size of the oil phase can be controlled within a wide range compared to conventional emulsion compositions that use surfactants. The average particle size of the oil phase can be measured by dynamic light scattering using a particle size distribution analyzer FPAR (manufactured by Otsuka Electronics Co., Ltd.) and obtained by Contin analysis.

[0028] The content of the oil phase in the hair penetrating and / or hair coating emulsion composition is appropriately selected depending on the application of the hair penetrating and / or hair coating emulsion composition, etc. The content of the oil phase is, for example, 3.0% by mass or more, 5.0% by mass or more, or 10.0% by mass or more.

[0029] The aqueous phase of the hair-penetrating and / or hair-coating emulsion composition is an aqueous component, does not mix with the oil phase, is a continuous phase, and disperses a plurality of emulsion particles. The aqueous phase is, for example, water.

[0030] The content of the aqueous phase in the hair penetrating and / or hair-coating emulsion composition is appropriately selected depending on the application of the hair penetrating and / or hair-coating emulsion composition, etc. The content of the aqueous phase may be, for example, 60.0% by mass or more, 75.0% by mass or more, and may be 95.0% by mass or less, 90.0% by mass or less.

[0031] The nanoparticles of the hair-penetrating and / or hair-coating emulsion composition are hydrophilic and have an affinity for cortex cells.

[0032] When such nanoparticles are closed vesicles, the amphiphilic substance that spontaneously forms closed vesicles (hereinafter, simply referred to as amphiphilic substance) is an amphiphilic substance that has the ability to spontaneously form closed vesicles in water, for example, one that can form a bilayer membrane in water (i.e., one that can form a vesicle in water).As the amphiphilic substance, a derivative of polyoxyethylene hydrogenated castor oil represented by the following formula (1) is suitable.

[0033] [ka]

[0034] In the formula (1), the average number of moles of ethylene oxide added, E (E = L + M + N + X + Y + Z), is preferably 3 or more and 100 or less.

[0035] In addition to the above, other suitable examples of amphipathic substances include phospholipids and phospholipid derivatives, particularly those in which a hydrophobic group and a hydrophilic group are bonded via an ester bond.

[0036] As the phospholipid, among the structures represented by the following formula (3), DLPC (1,2-Dilauroyl-sn-glycero-3-phospho-rac-1-choline) with a carbon chain length of 12, DMPC (1,2-Dimyristoyl-sn-glycero-3-phospho-rac-1-choline) with a carbon chain length of 14, and DPPC (1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-1-choline) with a carbon chain length of 16 are preferred.

[0037] [ka]

[0038] Among the structures represented by the following formula (4), the Na salt or NH4 salt of DLPG (1,2-Dilauroyl-sn-glycero-3-phospho-rac-1-glycerol) having a carbon chain length of 12, the Na salt or NH4 salt of DMPG (1,2-Dimyristoyl-sn-glycero-3-phospho-rac-1-glycerol) having a carbon chain length of 14, and the Na salt or NH4 salt of DPPG (1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-1-glycerol) having a carbon chain length of 16 are preferred.

[0039] [ka]

[0040] Further, suitable examples of phospholipids include lecithin such as egg yolk lecithin or soybean lecithin.

[0041] Further, preferred examples of the amphiphilic substance include fatty acid esters, such as glycerin fatty acid esters, polyglycerin fatty acid esters, sucrose fatty acid esters, sorbitan fatty acid esters, and propylene glycol fatty acid esters.

[0042] As the polyglycerol fatty acid ester, the fatty acid is preferably a straight-chain fatty acid or a branched fatty acid, regardless of whether it is saturated or unsaturated, and is an ester of the fatty acid with polyglycerol. Among these, polyglyceryl monomyristate, polyglyceryl dimyristate, polyglyceryl trimyristate, polyglyceryl monopalmitate, polyglyceryl dipalmitate, polyglyceryl tripalmitate, polyglyceryl monostearate, polyglyceryl distearate, polyglyceryl tristearate, polyglyceryl monoisostearate, polyglyceryl diisostearate, polyglyceryl triisostearate, polyglyceryl pentaisostearate, polyglyceryl monooleate, polyglyceryl dioleate, polyglyceryl trioleate, polyglyceryl pentaoleate, and polyglyceryl polyricinoleate are more preferred.

[0043] As the sucrose fatty acid ester, sucrose laurate, sucrose myristic acid ester, sucrose palmitate, sucrose stearate, and sucrose oleate are preferred.

[0044] When the nanoparticles are particles of polycondensation polymers, the polycondensation polymers having hydroxyl groups (hereinafter simply referred to as polycondensation polymers) may be any of natural polymers, synthetic polymers, or semi-synthetic polymers. Among them, the polycondensation polymer is preferably a natural polymer because it is safe and generally inexpensive, and more preferably a sugar polymer because it has excellent emulsification function.

[0045] Sugar polymers are polymers having a glycoside structure, such as cellulose and starch. For example, preferred are those produced by microorganisms using several sugars selected from monosaccharides such as ribose, xylose, rhamnose, fucose, glucose, mannose, glucuronic acid, and gluconic acid as building blocks; natural polymers such as xanthan gum, gum arabic, guar gum, karaya gum, carrageenan, pectin, fucoidan, quince seed gum, trant gum, locust bean gum, galactomannan, curdlan, gellan gum, fucogel, casein, gelatin, starch, collagen, hyaluronic acid, hyaluronic acid derivatives, and Tremella fuciformis polysaccharides; semi-synthetic polymers such as methylcellulose, ethylcellulose, methylhydroxypropylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, propylene glycol alginate, cellulose crystals, starch-sodium acrylate graft polymer, and hydrophobized hydroxypropylmethylcellulose; and synthetic polymers such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymers, polyacrylates, and polyethylene oxide.

[0046] In addition, the nanoparticles preferably have at least one of ceramide and sterol. In particular, the nanoparticles preferably have at least one of unsaturated fatty acid, basic amino acid, ceramide and sterol, because of their high affinity with hair components. The nanoparticles may have only ceramide, only sterol, or both ceramide and sterol, as the amphipathic oils, of ceramide and sterol.

[0047] As the unsaturated fatty acid, a monounsaturated fatty acid or a polyunsaturated fatty acid is preferable because of its high affinity with hair components, and among them, oleic acid, linoleic acid, and linolenic acid are more preferable.

[0048] The basic amino acid is preferably at least one of lysine and L-arginine because of its high affinity with hair components. The basic amino acid may be lysine alone, L-arginine alone, or a combination of lysine and L-arginine.

[0049] As the ceramide, since it has high affinity with hair components, it is preferable that it is one or more selected from the group consisting of human ceramide, plant ceramide, and pseudo ceramide. Among them, it is more preferable that it is ceramide 2, ceramide 3, ceramide 5, sugar ceramide, and pseudo ceramide. For example, the ceramide may be only human ceramide, or may be used in combination with plant ceramide and pseudo ceramide.

[0050] The sterol is preferably at least one of cholesterol and phytosterol because it has a high affinity with hair components. The sterol may be only cholesterol, only phytosterol, or a combination of cholesterol and phytosterol.

[0051] Alternatively, the nanoparticles may consist only of unsaturated fatty acids, basic amino acids, and at least one of ceramides and sterols.

[0052] Since ceramides, sterols, and unsaturated fatty acids are CMC components, and basic amino acids are cortex cell components, the nanoparticles have excellent biocompatibility and also have excellent affinity for cortex cells.

[0053] In addition, the nanoparticles preferably have an ionic amphiphilic substance that contains an unsaturated fatty acid and a basic amino acid and spontaneously forms nanoparticles in water, in relation to the unsaturated fatty acid and basic amino acid that the nanoparticles themselves have. In this case, the nanoparticles may be composed of only the ionic amphiphilic substance and at least one of ceramide and sterol. The ionic amphiphilic substance may be composed of only the unsaturated fatty acid and the basic amino acid.

[0054] In addition, the nanoparticles other than the above include phytantriol and sodium dilauroyl glutamate lysine. In this case, the nanoparticles may be composed of only phytantriol and sodium dilauroyl glutamate lysine.

[0055] The average particle size of the nanoparticles is preferably 8 nm or more and 800 nm or less, more preferably 8 nm or more and 500 nm or less, and even more preferably 8 nm or more and 400 nm or less. When the average particle size of the nanoparticles is within the above range, the nanoparticles are favorable as an emulsifier for three-phase emulsification to realize a hair penetrating and / or hair-coating emulsion composition, and the emulsifiability of the hair penetrating and / or hair-coating emulsion composition can be improved.

[0056] The average particle size of the nanoparticles can be measured by dynamic light scattering using a particle size distribution analyzer FPAR (manufactured by Otsuka Electronics Co., Ltd.) and determined by Contin analysis.

[0057] The content of nanoparticles in the hair penetrating and / or hair coating emulsion composition is appropriately selected depending on the application of the hair penetrating and / or hair coating emulsion composition.

[0058] Furthermore, the hair-penetrating and / or hair-coating emulsion composition may contain various other ingredients in addition to the above-mentioned ingredients, so long as the emulsion particles are unlikely to be destroyed even when adsorbed to the cuticle, many active ingredients can efficiently penetrate into the cortex, and the hair surface can be coated and protected.

[0059] Next, a method for producing the above-mentioned hair-penetrating and / or hair-coating emulsion composition will be described.

[0060] In the method for producing the hair penetration and / or hair coating emulsion composition, a three-phase emulsification technique is used in which a dispersion in which a plurality of nanoparticles are dispersed in an aqueous component is stirred with a stirrer or the like while an oily component is added to the dispersion to form a plurality of emulsion particles, thereby obtaining a hair penetration and / or hair coating emulsion composition containing a plurality of emulsion particles dispersed in an aqueous phase. The emulsion particles have droplets in which the surface of the oil phase is covered with a plurality of nanoparticles.

[0061] An example of a method for preparing a dispersion in which nanoparticles are dispersed in an aqueous component is the method described in Japanese Patent No. 3855203.

[0062] Another example of a method for preparing a dispersion in which nanoparticles are dispersed in an aqueous component is a method having a heating and dissolving step and a stirring step.

[0063] In the heat dissolution step, the unsaturated fatty acid and at least one of the ceramide and the sterol are heated and dissolved to obtain a mixed solution. The mixed solution contains the unsaturated fatty acid and at least one of the ceramide and the sterol. The temperature of the heat dissolution step is not particularly limited as long as it is a temperature at which the unsaturated fatty acid and at least one of the ceramide and the sterol can be sufficiently dissolved and these substances are not denatured.

[0064] In addition, in the heat dissolving step, the unsaturated fatty acid, at least one of the ceramide and the sterol, and the co-solvent may be heated and dissolved to obtain a mixed solution. When the unsaturated fatty acid, at least one of the ceramide and the sterol are heated and dissolved, the co-solvent is used to easily obtain a mixed solution. The co-solvent is preferably butylene glycol, dipropylene glycol, or pentanediol.

[0065] In the stirring step performed after the heating and dissolving step, the mixture obtained in the heating and dissolving step is stirred with the aqueous basic amino acid solution to obtain a dispersion in which nanoparticles are dispersed. In the stirring step, the heated aqueous basic amino acid solution may be mixed with the mixture. The stirring conditions in the stirring step, such as the stirring speed and the stirring temperature, are not particularly limited as long as nanoparticles can be obtained by stirring the mixture and the aqueous basic amino acid solution.

[0066] Although the embodiments have been described above, the present invention is not limited to the above embodiments, but includes all aspects included in the concept and scope of the claims of the present disclosure, and can be modified in various ways within the scope of the present disclosure. EXAMPLES

[0067] Next, examples and comparative examples will be described, but the present invention is not limited to these examples.

[0068] Example 1 First, oleic acid, cholesterol, and ceramide 2 in the amounts shown in Table 1 were heated to 150°C and dissolved to obtain a mixed solution. Next, an L-arginine aqueous solution heated to 85°C (the amount of L-arginine and the amount of water in the aqueous solution are shown in Table 1) was added to the mixed solution, and the mixture was stirred at 85°C for 10 minutes. After stirring, the aqueous solution was cooled to 25°C to obtain a nanoparticle dispersion in which nanoparticles composed of oleic acid, cholesterol, ceramide 2, and L-arginine were dispersed. Next, based on the three-phase emulsification method, the nanoparticle dispersion was stirred at 10,000 rpm at 25°C with a homomixer, while adding tri(caprylic / capric acid)glyceryl and Nile red (a fluorescent dye for fluorescent microscopy observation described later) in the amounts shown in Table 1, and the mixture was stirred for 20 minutes to obtain an emulsion composition.

[0069] Comparative Example 1 First, the amounts of water and the surfactant hexadecyltrimethylammonium chloride shown in Table 2 were mixed, and then the solution was stirred at 10,000 rpm and 25°C with a homomixer. The amounts of caprylic / capric triglyceride and Nile red shown in Table 2 were added and stirred for 3 minutes to obtain an emulsion composition.

[0070] The hair permeability and hair coverage of the emulsion compositions of Example 1 and Comparative Example 1 were evaluated as follows.

[0071] First, damaged hair to be used for evaluation was prepared as follows. Healthy hair (hair bundle 100% black hair, BS-BA, Beaulux Co., Ltd.) was washed with a detergent (polyoxyethylene (2) sodium lauryl sulfate 8% aqueous solution), rinsed with tap water, and then dried. Next, the hair was damaged by applying a bleaching agent (Beauteen, Base Up Bleach, Hoyu Co., Ltd.), rinsing with tap water, and drying, a total of three times. Damaged hair was obtained.

[0072] The weight of one bundle of damaged hair was immersed in 25 g of the emulsion composition at 25° C. for 6 hours. The damaged hair removed from the emulsion composition was then rinsed with 500 mL of ion-exchanged water, and then naturally dried in a desiccator. Thus, a sample hair was obtained. The weight of the sample hair was measured. Then, the sample in which the sample hair was embedded in the resin was cut perpendicular to the longitudinal direction of the sample hair at a thickness of 10 μm. The cross section of the sample hair in the cut sample was observed with a fluorescent microscope (BX53, Olympus). Tables 1-2 show the weight of the hair (one bundle of damaged hair, not including moisture) before immersion in the emulsion composition, the weight of the hair (one bundle of sample hair, not including moisture) after immersion in the emulsion composition, and the weight increase. Tables 1-2 also show the results of evaluation based on images of the cross section of the sample hair observed with a fluorescent microscope. The hair penetration of the emulsion composition for damaged hair was ranked as follows. Only rank ◯ was judged to be excellent in hair penetration, while ranks Δ and × were judged to be poor in hair penetration.

[0073] ○: Permeation of the fluorescent reagent into the cortex was confirmed. △: A small amount of the fluorescent reagent was observed to permeate into the cortex. ×: No penetration of the fluorescent reagent into the cortex was observed.

[0074] [Table 1]

[0075] [Table 2]

[0076] FIG. 1 is an image of a cross section of a sample hair obtained by immersing in the emulsion composition of Example 1, observed under a fluorescent microscope. FIG. 2 is an image of a cross section of a damaged hair obtained by immersing in water for 6 hours without immersing in the emulsion composition of Example 1, observed under a fluorescent microscope, as a reference example. FIG. 3 is an image of a cross section of a sample hair obtained by immersing in the emulsion composition of Comparative Example 1, observed under a fluorescent microscope. As shown in FIG. 1, the emulsion composition of Example 1 had penetrated into the cortex layer. Furthermore, the emulsion composition of Example 1 was confirmed to be adsorbed to the cuticle, and therefore coated the hair surface. On the other hand, as shown in FIG. 2, the fluorescence of the cortex layer could not be confirmed in the damaged hair immersed in water instead of the emulsion composition of Example 1. As shown in FIG. 3, the emulsion composition of Comparative Example 1 was clearly confirmed to be adsorbed to the cuticle, but the penetration into the cortex layer was very slight. Furthermore, in the weight measurement, the weight increased in Example 1 and Comparative Example 1. From the above, the emulsion composition of Example 1 penetrated well into the cortex layer and coated well on the hair surface, and as a result, the weight increased, and therefore the emulsion composition had excellent hair permeability and hair covering properties. On the other hand, the weight also increased in Comparative Example 1, but most of the emulsion composition was adsorbed to the cuticle, and therefore the emulsion composition of Comparative Example 1 had poor hair permeability.

[0077] Example 2 The same emulsion composition as in Example 1 was used. Then, the weight change of the hair bundle before and after immersion, the hair permeability and the hair coverage were evaluated in the same manner as in Example 1, except that the immersion time of the damaged hair was 30 minutes. The results are shown in Tables 5 and 6. Also, FIG. 4 is an image of the cross section of the sample hair obtained by immersing in the emulsion composition of Example 2, observed with a fluorescent microscope. Thus, even when the immersion time of the damaged hair in the emulsion composition was shortened, the hair permeability effect and the hair coverage effect of the emulsion composition were observed in the same manner as in Example 1.

[0078] Example 3 The emulsion composition was used in the same manner as in Example 1, except that the nanoparticle dispersion was stirred at 6000 rpm. Then, the weight change of the hair bundle before and after immersion, and the hair penetration and hair coverage were evaluated in the same manner as in Example 2. The results are shown in Tables 5 to 6. FIG. 5 is an image of the cross section of the sample hair obtained by immersing in the emulsion composition of Example 3, observed with a fluorescent microscope. The average particle size of the emulsion of Example 3 was 397.6 nm. Thus, even when the average particle size of the emulsion was changed and the immersion time of the damaged hair was shortened, the emulsion composition had the same hair penetration effect and hair coverage effect as in Example 1.

[0079] Example 4 First, 1,2-pentanediol, phytantriol, and sodium dilauroyl glutamate lysine solution (30% aqueous solution) in the amounts shown in Table 3 were dissolved, and then water in the amount shown in Table 3 was added and mixed to obtain a nanoparticle dispersion in which nanoparticles composed of phytantriol and sodium dilauroyl glutamate lysine were dispersed. Next, based on the three-phase emulsification method, tri(capryl-capric acid)glyceryl and Nile red in the amounts shown in Table 3 were added while stirring the nanoparticle dispersion with a homomixer at 10,000 rpm and 25°C, and stirred for 20 minutes to obtain an emulsion composition. Then, in the same manner as in Example 2, the weight change of the hair bundle before and after immersion, the hair penetration property, and the hair coverage property were evaluated. The results are shown in Tables 5 to 6. Also, FIG. 6 is an image of the cross section of the sample hair obtained by immersing it in the emulsion composition of Example 4, observed with a fluorescent microscope. Thus, even when the type of emulsion composition was changed and the immersion time of damaged hair was shortened, the emulsion composition had the same hair penetration effect and hair coating effect as in Example 1.

[0080] [Table 3]

[0081] Example 5 First, a nanoparticle dispersion was obtained by mixing a 0.5% aqueous solution of hydrophobized hydroxypropyl methylcellulose nanoparticles with water. Next, based on the three-phase emulsification method, tri(capryl-capric acid)glyceryl and Nile red in the amounts shown in Table 4 were added while stirring the nanoparticle dispersion with a homomixer at 6000 rpm and 25°C, and the mixture was stirred for 20 minutes to obtain an emulsion composition. Then, in the same manner as in Example 2, the weight change of the hair bundle before and after immersion, the hair penetration and hair coverage were evaluated. The results are shown in Tables 5 to 6. Also, FIG. 7 is an image of the cross section of the sample hair obtained by immersing in the emulsion composition of Example 5, observed with a fluorescent microscope. Thus, even when the type of emulsion composition was changed and the immersion time of the damaged hair was shortened, the hair penetration effect and hair coverage effect of the emulsion composition were observed in the same manner as in Example 1.

[0082] [Table 4]

[0083] [Table 5]

[0084] [Table 6]

[0085] Example 6 First, the amounts of oleic acid, cholesterol, and ceramide 2 shown in Table 7 were heated to 150°C and dissolved to obtain a mixed solution. Next, an L-arginine aqueous solution heated to 85°C (the amount of L-arginine and the amount of water in the aqueous solution are shown in Table 1) was added to the mixed solution, mixed, and stirred at 85°C for 10 minutes. After stirring, the aqueous solution was cooled to 25°C to obtain a nanoparticle dispersion in which nanoparticles composed of oleic acid, cholesterol, ceramide 2, and L-arginine were dispersed. Next, based on the three-phase emulsification method, the amount of tri(caprylic / capric acid)glyceryl shown in Table 7 was added while stirring the nanoparticle dispersion with a homomixer at 6000 rpm at 25°C, and the mixture was roughly emulsified by stirring for 20 minutes, and then emulsified three times with a high-pressure emulsifier (SUGINO Star Burst mini HJP-25001) at a spray pressure of 150 MPa to obtain an emulsion composition.

[0086] The following sensory evaluation was performed on the emulsion composition obtained in Example 6. First, seven women in their 20s to 50s washed their hair with shampoo. Next, the emulsion composition obtained in Example 6 was applied to the hair, and then rinsed. Regarding the feel of the dried hair when used, the subjects were asked about the smoothness of the hair and the moistness of the hair. As a result, all subjects answered that the smoothness of the hair was good. Regarding the moistness of the hair, six subjects answered that it was good, and one subject answered that it was bad. From these results, it was found that the emulsion composition of Example 6 is a hair-penetrating and / or hair-coating emulsion composition that shows a feel of use equal to or better than that of a general hair conditioning preparation (cationic conditioner (using a cationic surfactant)).

[0087] Thus, the emulsion composition of the present invention is less likely to destroy emulsion particles even when adsorbed to the cuticle, and in addition to being able to efficiently penetrate many active ingredients into the cortex, it is also possible to coat and protect the hair surface. In other words, the emulsion composition of the present invention is capable of serving as a substitute for cationic conditioners.

[0088] [Table 7]

Claims

1. An oil phase; An aqueous phase; Nanoparticles and Including, The nanoparticles are at least one of closed vesicles formed by an amphiphilic substance that spontaneously forms closed vesicles and particles of a polycondensation polymer having hydroxyl groups, in a hair-penetrating and / or hair-coating emulsion composition.

2. The hair penetration and / or hair coating emulsion composition according to claim 1 , which is an O / W type emulsion.

3. The hair-penetrating and / or hair-coating emulsion composition according to claim 1 , wherein the nanoparticles are present at the interface between the oil phase and the aqueous phase.

4. The hair-penetrating and / or hair-coating emulsion composition according to claim 1 , wherein the nanoparticles have an affinity for cortex cells.

5. The hair-penetrating and / or hair-coating emulsion composition according to claim 1 , wherein the nanoparticles contain at least one of a ceramide and a sterol.

6. 2. The hair-penetrating and / or hair-coating emulsion composition according to claim 1, wherein the nanoparticles comprise an unsaturated fatty acid, a basic amino acid, and at least one of a ceramide and a sterol.

7. The hair-penetrating and / or hair-coating emulsion composition according to claim 6 , wherein the unsaturated fatty acid is a monounsaturated fatty acid or a polyunsaturated fatty acid.

8. 7. The hair-penetrating and / or hair-coating emulsion composition according to claim 6, wherein the basic amino acid is at least one of lysine and L-arginine.

9. 7. The hair-penetrating and / or hair-coating emulsion composition according to claim 6, wherein the ceramide is at least one selected from the group consisting of human ceramide, plant ceramide, and pseudo-ceramide.

10. The hair-penetrating and / or hair-coating emulsion composition according to claim 6 , wherein the sterol is at least one of cholesterol and phytosterol.

11. The hair-penetrating and / or hair-coating emulsion composition according to claim 1 , wherein the nanoparticles comprise phytantriol and sodium dilauroyl glutamate lysine.

12. The hair-penetrating and / or hair-coating emulsion composition according to claim 1 , wherein the nanoparticles comprise hydrophobized hydroxypropyl methylcellulose.

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