Triamine-based disinfectant and cleaning composition

Abstract

The present invention relates to a disinfectant cleaning composition comprising at least one triamine based antimicrobial agent, at least one pH dependent anionic surfactant and at least one non-ionic surfactant, which provides effective disinfection, cleaning and low streaking or visual residue on surfaces.

Description

[Technical field]

[0001] The present invention relates to a disinfectant cleaning composition comprising at least one triamine antimicrobial agent, at least one pH-dependent anionic surfactant and at least one nonionic surfactant. The disinfectant cleaning composition of the present invention provides effective disinfection using only low amounts of antimicrobial agent, and shows good cleaning and low streaking and / or visual residue on surfaces. [Background technology]

[0002] A disinfectant cleaning composition refers to any composition that includes both cleaning and disinfecting effects. The disinfecting effect is thereby achieved by an antimicrobial agent that can kill, destroy, or inhibit the growth of living organisms, especially microorganisms. Products that include a disinfectant cleaning composition include hard surface cleaners, hand sanitizers, pre-disinfectant cleaners for instruments, sterilization and high-level disinfectant cleaning compositions, etc. Ideally, the antimicrobial agent has broad-spectrum activity against all kinds of microorganisms. Furthermore, the exposure time of the disinfectant cleaning composition to the surface should be as short as possible. The disinfectant cleaning composition should also have high efficacy so that a minimum amount of antimicrobial agent can be used to save costs and avoid or reduce any possible adverse effects caused by the antimicrobial agent. Also, the end user's exposure to the antimicrobial agent can be minimized by using a low amount of antimicrobial agent and / or a short exposure time. It is also desirable for the disinfectant cleaning composition to effectively clean surfaces with low streaking and / or low visual residue on the surface. Furthermore, it is also preferable that the disinfectant cleaning composition results in a stable product pH value even when diluted. The combination of an amine-based antimicrobial agent and a non-ionic surfactant is known in the art. The use of nonionic surfactant alone in such compositions is less effective for cleaning than the combination of nonionic surfactant and pH-dependent anionic surfactant.However, anionic surfactants are generally known to be antagonistic to amine-based antimicrobial agents, compromising their antimicrobial efficacy, and therefore disinfectant cleaners that contain anionic surfactants generally require higher end-use levels of amine-based antimicrobial agents.

[0003] Surprisingly, the inventors have found that a disinfectant cleaning composition comprising at least one triamine antimicrobial agent at low levels together with at least one nonionic surfactant and at least one pH-dependent anionic surfactant is effective as a biocidal composition and provides good cleaning efficiency against greasy and granular soils, thus solving the above problems.This also results in a stable product pH level even after dilution. Summary of the Invention

[0004] It is an object of the present invention to provide a disinfectant cleaning composition that is effective for cleaning and disinfecting, comprising a small amount of at least one triamine antimicrobial agent in combination with at least one nonionic surfactant and at least one pH-dependent anionic surfactant having an isoelectric point (IEP) greater than pH 0 and less than the pH of the disinfectant cleaning composition, said composition having a pH between 8.5 and 12.

[0005] The combination of at least one triamine antimicrobial agent, at least one pH-dependent anionic surfactant and one nonionic surfactant in this specific pH range allows to reduce the amount of triamine antimicrobial agent required for high antimicrobial efficacy. The specific pH of 8.5-12 is high enough to ensure that the surfactants are in their anionic form and at the same time low enough to ensure the germicidal efficacy of the triamine antimicrobial agent. Furthermore, the disinfectant cleaning composition is essentially free, preferably free, of widely used biocidal active quaternary ammonium compounds. Furthermore, the disinfectant cleaning composition is essentially free, preferably free, of non-aqueous solvents. This makes the disinfectant cleaning composition of the present invention less harmful to the environment and / or applicable to many solvent-labile surfaces. Surprisingly, the effectiveness of the disinfectant cleaning composition of the present invention in cleaning efficacy is not reduced despite the presence of anionic surfactant and the antimicrobial efficacy is even increased. This disinfectant cleaning composition results in highly effective disinfection, cleaning and low streaking and / or visual residue on surfaces. [Brief description of the drawings]

[0006] [Figure 1]FIG. 1 shows the results of cleaning tests carried out on hard surfaces with the composition of the invention (composition I.1 ("C I.1"), see Table 1) at a 1:100 dilution ("RTU C I.1"), water, and two comparative compositions (compositions A and B). FIG. 1 shows the results of a hard surface after cleaning with the above composition of the invention (composition I.1 (C I.1), see Table 1) at a 1:100 dilution ("RTU C I.1"), water, and two comparative compositions (compositions A and B). [Diagram 2] FIG. 2 shows the results of cleaning tests carried out on hard surfaces with a composition of the invention (composition I.1 ("C I.1"), see Table 1) at 1:100 dilution ("RTU C I.1"), water, and two comparative compositions (compositions A and B). FIG. 2 is a column chart showing the cleaning efficacy of a composition of the invention (composition I.1 ("RTU C I.1"), see Table 1) at 1:100 dilution, water, and two comparative compositions (compositions A and B). As can be derived from FIG. 1 and FIG. 2, the cleaning performance of composition I and compositions A and B was better than water and comparable to each other. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0007] As used in this disclosure and the claims, the singular forms "a," "an," and "the" include the plural forms unless the context clearly dictates otherwise.

[0008] pH ranges recited herein, such as "pH 8.5 to 12," include the recited values ​​and all values ​​in between, such as pH 8.6, 8.7, 8.8, 8.9, 9, 9.1, 9.2, 9.3, 9.4, 9.5, 9.6, 9.7, 9.8, 9.9, 10, 10.1, 10.2, 10.3, 10.4, 10.5, 10.6, 10.7, 10.8, 10.9, 11, 11.1, 11.2, 11.3, 11.4, 11.5, 11.6, 11.7, 11.8, and 11.9. pH can be measured at 25° C. using, for example, a standard glass bulb pH meter, as is well known in the art.

[0009] Unless otherwise specified, the term "%" or "percentage" as used herein refers to "weight percentage" (also referred to herein as "wt %").

[0010] As used herein, the term "alkyl" or "alkyl group" refers to a saturated hydrocarbon having one or more carbon atoms, including straight chain alkyl groups (e.g., methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, etc.), cyclic alkyl groups (or "cycloalkyl" or "alicyclic" or "carbocyclic" groups) (e.g., cyclopropyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, etc.), branched chain alkyl groups (e.g., isopropyl, tert-butyl, sec-butyl, isobutyl, etc.), and alkyl substituted alkyl groups (e.g., alkyl substituted cycloalkyl groups and cycloalkyl substituted alkyl groups). As used herein, an "alkyl" or "alkyl group" contains between 1 and 30 carbon atoms (C1-C30), preferably between 1 and 24 carbon atoms, more preferably between 1 and 16 carbon atoms, and even more preferably between 1 and 8 carbon atoms.

[0011] Unless otherwise specified, the term "alkyl" includes both "unsubstituted alkyls" and "substituted alkyls." As used herein, the term "substituted alkyls" refers to alkyl groups having substituents replacing one or more hydrogens on one or more carbons of the hydrocarbon backbone. Such substituents may include, for example, alkenyl, alkynyl, halogeno, hydroxyl, alkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aryloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylthiocarbonyl, alkoxyl, phosphate, phosphonato, phosphinato, cyano, amino (including alkylamino, dialkylamino, arylamino, diarylamino, and alkylarylamino), acylamino (including alkylcarbonylamino, arylcarbonylamino, carbamoyl, and ureido), imino, sulfhydryl, alkylthio, arylthio, thiocarboxylate, sulfate, alkylsulfinyl, sulfonate, sulfamoyl, sulfonamido, nitro, trifluoromethyl, cyano, azido, heterocyclic, alkylaryl, or aromatic (including heteroaromatic) groups.

[0012] The present disclosure generally relates to a disinfectant cleaning composition for disinfecting and cleaning surfaces.As used herein, the term "disinfectant cleaning composition" can be understood as any composition that includes both cleaning and disinfecting effects.The disinfectant cleaning composition can provide not only rapid initial antimicrobial kill across a wide range of microorganisms, but also provide antimicrobial activity over a long period of time.

[0013] In general, the disinfectant cleaning composition of the present invention comprises at least one triamine antimicrobial agent, at least one pH-dependent anionic surfactant, and at least one nonionic surfactant, and has a pH of 8.5-12. The at least one pH-dependent anionic surfactant has an isoelectric point (IEP) lower than the pH of the disinfectant cleaning composition, but higher than pH 0. The combination of certain pH-dependent anionic surfactants and nonionic surfactants with triamine antimicrobial agents provides high antimicrobial efficacy at a pH of 8.5-12, and can kill a wide range of microorganisms in a short time in the presence of only small amounts of antimicrobial agents. Thus, end-user exposure to the antimicrobial agent is minimized. The use of triamine antimicrobial agents provides that maximum resilience of biocidal activity can be achieved in the presence of pH-dependent anionic surfactants.

[0014] <Triamine antibacterial agent> The "triamine antimicrobial agents" present in the compositions of the present invention are active against microorganisms and have the potential to kill at least one microorganism and / or control the growth of the microorganism, the growth of which can be controlled such that the rate of growth of the microorganism is reduced or completely inhibited.

[0015] As used herein, the term "microorganism" refers to any non-cellular or unicellular (including colonial) organism. Microorganisms include all prokaryotes. Microorganisms include bacteria (including cyanobacteria), spores, lichens, fungi, protozoa, virinos, viroids, viruses, phages, and some algae. A variety of different microorganisms can be killed or controlled. For example, the disinfectant cleaning composition can control gram-positive bacteria, gram-negative bacteria, and the like. In addition to bacteria, the antimicrobial compositions of the present disclosure can also kill and control the growth of a variety of other microorganisms, such as fungi, viruses, spores, yeast, and mycobacteria. Examples of specific microorganisms that may be killed or controlled in accordance with the present disclosure include Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Serratia marcescens, Salmonella enteritidis, Neisseria gonorrhoeae, Escherichia coli, Enterococcus hirae, Acinetobacter baumannnii, Listeria monocytogenes, Enterobacter gergoviae, Klebsiella pneumoniae, and the like. pneumoniae, Burholderia cepacia, Pseudomonas putida, Kocuria rhizophila, Candida albicans, Saccharomyces cerevisiae, Aspergillus brasiliensis, Penicilfium funiculosumfuniculosum, Eupenicillium levitum, Bacillus cereus, Bacillus subtilis, Clostridium difficile, Clostridium perfringens, Mycobacterium tuberculosis, Mycobacterium terrae, Mycobacterium avium, poliovirus, adenovirus, norovirus, vaccinia virus, influenza virus, hepatitis B virus, human immunodeficiency virus, human papillomavirus, or a combination thereof. More preferably, the different microorganisms that can be killed or controlled by the disinfectant cleaning composition of the present invention can be Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Enterococcus hirae and Candida albicans.

[0016] The triamine antibacterial agent comprises three amino groups. The amino groups may be, individually, primary, secondary or tertiary amino groups. In certain embodiments, at least one of the amino groups contained in the triamine antibacterial agent is a tertiary amino group. In certain embodiments, at least one of the amino groups contained in the triamine antibacterial agent is a primary amino group. In certain embodiments, the amino groups contained in the triamine antibacterial agent are at least one primary amino group and at least one tertiary amino group. In certain embodiments, the amino groups contained in the triamine antibacterial agent are two primary amino groups and one tertiary amino group.

[0017] The at least one triamine antimicrobial agent can be selected from the group consisting of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine, N-(3-aminopropyl)-N-decyl-1,3-propanediamine, N-(3-aminopropyl)-N-tetradecyl-1,3-propanediamine, and combinations thereof; preferably, the antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine.

[0018] It is understood that successful microbial reduction is achieved when the microbial population is reduced by at least about 25%, preferably at least about 50%, more preferably at least about 75%, or significantly more than that achieved by washing with water. A greater reduction in the microbial population provides a higher level of protection.

[0019] The disinfectant cleaning composition of the present invention is essentially free, preferably free, of biocidal active quaternary ammonium compounds. As used herein, "essentially free" means that the composition may contain very small amounts of each component, for example less than 10% by weight of the composition, more preferably less than 5%, 3%, 1%, 0.5% or 0.3% by weight of the composition.

[0020] The disinfectant cleaning composition of the invention comprises biocidally active quaternary ammonium compounds in an amount of less than 1% by weight, preferably less than 0.5% by weight, more preferably less than 0.3% by weight. However, it is preferred that no biocidally active quaternary ammonium compounds are present in the disinfectant cleaning composition.

[0021] "Biocidally active quaternary ammonium compounds" are known to those skilled in the art and are, for example, alkyldimethylbenzyl ammonium chloride, dialkylmethylbenzyl ammonium chloride, dialkyldimethylammonium chloride, alkyldimethylethylbenzyl quaternary ammonium chloride, benzethonium chloride, or non-halogenated quaternary compounds such as didecylmethylpoly(oxyethyl)ammonium propionate.

[0022] <ph> In general, the disinfectant cleaning composition has a pH of 8.5 to 12. The pH value is preferably independent of the concentration of the composition, i.e. the composition exhibits similar pH values ​​in concentrated form as well as in diluted ready-to-use (RTU) form. "Similar pH values" means that the pH value varies slightly by values ​​less than 2, preferably less than 1.5, more preferably less than 1, even more preferably less than 0.5.

[0023] The disinfectant cleaning composition has a pH of 8.5 to 12, preferably 9 to 11. In the RTU form, the disinfectant cleaning composition also has a pH of 8.5 to 12, but preferably a pH of 8.5 to 10.5, more preferably a pH of 9 to 10.

[0024] Due to this mild pH range, the disinfecting and cleaning composition in RTU form is particularly environmentally friendly and therefore also suitable for pH-sensitive surfaces. The specific pH range of 8.5 to 12 ensures that at least one pH-dependent anionic surfactant is present in anionic form to provide high cleaning efficacy of the surfactant, but is low enough to ensure high germicidal efficacy of the triamine antimicrobial agent.

[0025] <Surfactant> The disinfectant cleaning composition comprises a beneficial combination of at least one pH-dependent anionic surfactant with an isoelectric point (IEP) higher than pH 0 and lower than the pH of said disinfectant cleaning composition, and at least one nonionic surfactant. Surprisingly, it has been found that the use of these particular surfactants in combination with triamine antimicrobial agents can reduce the amount of triamine antimicrobial agent required for high antimicrobial efficacy. The composition of the present invention exhibits high cleaning efficiency and low streaking and / or visual residue on hard surfaces.

[0026] The at least one triamine-based antibacterial agent and the two surfactants are present in the disinfection and cleaning composition of the present invention in a ratio of the total amount of at least one triamine-based antibacterial agent contained therein to the total amount of these surfactants between 1:08 and 1:4, preferably between 1:1 and 1:2, more preferably between 1:1 and 1:1.5.

[0027] <pH-dependent anionic surfactant> As used herein, the term "anionic surfactant" is generally understood as a surface-active substance classified as an "anionic" surfactant due to its negative charge, and this term also includes surfactants, the molecules of which do not carry a charge as long as the pH does not rise above neutral (e.g., carboxylic acid).

[0028] The pH range in which such molecules do not have a net charge (i.e., are electrically neutral on statistical average) is called the "isoelectric range". The average of that isoelectric range is called the isoelectric point (IEP). The isoelectric point of a molecule can be measured by methods known in the art. For example, the isoelectric range can be measured by isoelectric focusing electrophoresis. Another method for determining the IEP is titration.

[0029] The "net charge" of a pH-dependent anionic surfactant is affected by the pH of its surrounding environment and can be positively or negatively charged due to the acquisition or loss of a proton (H + ). The term "the net charge of the molecule is neutral" can be understood to mean that the number of negative charges is equal to the number of positive charges on the molecule or that the molecule is not charged. The net charge of a neutral molecule is zero.

[0030] The present disclosure distinguishes between "pH-dependent anionic surfactants" and "permanently anionic surfactants". "pH-dependent anionic surfactants" are defined as having an isoelectric point (IEP) higher than pH 0 (pH>0) and lower than the pH of the disinfectant cleaning composition of the present invention. This means that this type of anionic surfactant exists in anionic form in the pH range of the disinfectant cleaning composition disclosed herein, and when the pH is lowered to 0, all negative charges in the molecule are neutralized by protonation in these pH-dependent anionic surfactants.

[0031] In contrast, a "permanently anionic surfactant" is defined as having an isoelectric point below pH 0 (pH≦0). This means that this type of anionic surfactant remains in the anionic form when the pH is lowered from the alkaline range to 0.

[0032] In the disinfectant cleaning composition of the invention, the at least one pH-dependent anionic surfactant must have an isoelectric point (IEP) higher than pH 0 and lower than the pH of said disinfectant cleaning composition in order to ensure high antimicrobial activity of the at least one triamine based antimicrobial agent.

[0033] The pH dependent anionic surfactants used in the compositions according to the invention typically have no biocidal activity.

[0034] The at least one pH dependent anionic surfactant may be selected from the group consisting of alkyl carboxylates, alkyl ether carboxylates, alkyl propionates, alkyl ether propionates, amino acid based surfactants, and combinations thereof.

[0035] Suitable amino acid based surfactants include, but are not limited to, alkyl glutamates, alkyl alanins, alkyl glycinates, and alkyl sarcosinates.

[0036] In a preferred embodiment, the pH dependent anionic surfactant is an amino acid based surfactant selected from the group consisting of alkyl alaninates, alkyl glutamates, alkyl sarcosinates, alkyl glycinates, alkyl aspartates, and combinations thereof.

[0037] In certain embodiments, the pH dependent anionic surfactant is selected from the group consisting of β-alanine, N-(2-carboxyethyl) N-cocoalkyl derivatives, sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate, sodium N-(2-carboxyethyl)-N-octyl-β-alaninate, β-alanine N-(2-carboxyethyl) N-tallow alkyl derivatives, sodium cocoyl alaninate, sodium lauroyl alaninate, sodium N-dodecanoyl-L-alaninate, sodium cocoyl glutamate, dinatrium ... Umcocoyl glutamate, ammonium cocoyl glutamate, diammonium cocoyl glutamate, sodium lauroyl glutamate, disodium lauroyl glutamate, sodium cocoyl hydrolyzed wheat protein glutamate, disodium cocoyl hydrolyzed wheat protein glutamate, potassium cocoyl glutamate, dipotassium cocoyl glutamate, potassium lauroyl glutamate, dipotassium lauroyl glutamate, potassium cocoyl hydrolyzed wheat protein glutamate, dipotassium cocoyl hydrolyzed wheat protein glutamate Glutamate, Sodium Capryloyl Glutamate, Disodium Capryloyl Glutamate, Potassium Capryloyl Glutamate, Dipotassium Capryloyl Glutamate, Sodium Undecylenoyl Glutamate, Disodium Undecylenoyl Glutamate, Potassium Undecylenoyl Glutamate, Dipotassium Undecylenoyl Glutamate, Disodium Hydrogenated Tallow Glutamate, Sodium Stearoyl Glutamate, Disodium Stearoyl Glutamate, Potassium Stearoyl Glutamate, Dipotassium Stearoyl Glutamate , Sodium Myristoyl Glutamate, Disodium Myristoyl Glutamate, Potassium Myristoyl Glutamate, Dipotassium Myristoyl Glutamate, Sodium Cocoyl / Hydrogenated Tallow Glutamate, Sodium Cocoyl / Palmoyl / Sunflower Oil Glutamate, Sodium Hydrogenated Tallow Oil Glutamate, Sodium Olivoyl Glutamate, Disodium Olivoyl Glutamate, Sodium Palmoyl Glutamate, Disodium Palmoyl Glutamate, TEA-Cocoyl Glutamate, TEA-Hydrogenated Tallow Oil Glutamate,TEA-Lauroyl Glutamate, Sodium Lauroyl Sarcosinate, Sodium Cocoyl Sarcosinate, Sodium Myristoyl Sarcosinate, TEA-Cocoyl Sarcosinate, Ammonium Cocoyl Sarcosinate, Ammonium Lauroyl Sarcosinate, Dimer Dilinoleyl Bis-Lauroyl Glutamate / Lauroyl Sarcosinate, Disodium Lauroamphodiacetate Lauroyl Sarcosinate, Isopropyl Lauroyl Sarcosinate, Potassium Cocoyl Sarcosinate, Potassium Lauroyl Sarcosinate, Sodium The cocoyl sarcosinate is selected from the group consisting of sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, sodium oleoyl sarcosinate, sodium palmitoyl sarcosinate, TEA-cocoyl sarcosinate, TEA-lauroyl sarcosinate, TEA-oleoyl sarcosinate, TEA-palm kernel sarcosinate, sodium cocoyl glycinate, sodium lauroyl glycinate, sodium N-lauroyl aspartate, sodium N-dodecyl aspartate, and combinations thereof.

[0038] In a preferred embodiment, the pH dependent anionic surfactant is selected from the group consisting of β-alanine, N-(2-carboxyethyl) N-cocoalkyl derivatives, sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate, sodium N-(2-carboxyethyl)-N-octyl-β-alaninate, β-alanine N-(2-carboxyethyl) N-tallow alkyl derivatives, sodium cocoyl alaninate, sodium lauroyl alaninate, sodium N-dodecanoyl-L-alaninate, and combinations thereof.

[0039] In a more preferred embodiment, the at least one pH dependent anionic surfactant is sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate.

[0040] In another preferred embodiment, the disinfectant cleaning composition comprises sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate and at least one further pH-dependent anionic surfactant of the pH-dependent anionic surfactants listed above.

[0041] In another preferred embodiment the disinfectant cleaning composition comprises sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate and at least one further pH-dependent anionic surfactant selected from the group of β-alanine, N-(2-carboxyethyl) N-coco alkyl derivatives, sodium N-(2-carboxyethyl)-N-octyl-β-alaninate, β-alanine, N-(2-carboxyethyl) N-tallow alkyl derivatives, sodium cocoyl alaninate, sodium lauroyl alaninate, sodium N-dodecanoyl-L-alaninate, and combinations thereof.

[0042] The term "N-(2-carboxyethyl) N-cocoalkyl derivatives" as used herein includes alkyl residues of C1 to C22, preferably C2 to C16 atoms. These deviations may be in the form of sodium salts. For example, "β-alanine, N-(2-carboxyethyl) N-cocoalkyl derivatives" may be a material that is commercially available and has the CAS number [90170-43-7].

[0043] The term "N-(2-carboxyethyl) N-tallow alkyl derivatives" as used herein includes alkyl residues of C1 to C22, preferably C2 to C16 atoms. These deviations may be in the form of sodium salts. For example, "β-alanine, N-(2-carboxyethyl) N-tallow alkyl derivatives" is commercially available and may be a material having the CAS number [61791-56-8].

[0044] As used herein, the abbreviation "TEA" in a compound such as "TEA-cocoyl glutamate" refers to "triethanolamine."

[0045] In certain embodiments, the composition of the present invention comprises from 10% to 50% by weight, preferably from 15% to 35% by weight, 17.5% to 30% by weight, and more preferably from 20% to 25% by weight of the at least one pH-dependent anionic surfactant, based on the total weight of surfactants contained in the composition.

[0046] In one particular embodiment, the composition of the present invention comprises at least 10-35 wt. %, preferably at least 15-30 wt. %, more preferably 20-25 wt. % of said at least one pH-dependent anionic surfactant, based on the total weight of surfactants contained in said composition.

[0047] <Nonionic surfactant> The term "nonionic surfactant" generally refers to surfactants characterized by the presence of an organic hydrophobic group and an organic hydrophilic group; nonionic surfactants are known to those skilled in the art and are typically produced by the condensation of an organic aliphatic, alkylaromatic or polyoxyalkylene hydrophobic compound with a hydrophilic alkali oxide moiety, usually ethylene oxide or its polyhydration product, polyethylene glycol.

[0048] In fact, any hydrophobic compound having a hydroxyl, carboxyl, amino, or amide group with a reactive hydrogen atom can be condensed with ethylene oxide, or its polyhydrate adducts, or mixtures thereof with alkoxylene such as propylene oxide, to form a nonionic surfactant. The length of the hydrophilic polyoxyalkylene moiety condensed with any particular hydrophobic compound can be easily adjusted to obtain a water-dispersible or water-soluble compound having the desired degree of balance between hydrophilicity and hydrophobicity.

[0049] Useful nonionic surfactants include the condensation products of one mole of a saturated or unsaturated, straight or branched chain alcohol having from about 6 to about 24 carbon atoms with from about 3 to about 50 moles of ethylene oxide. The alcohol portion can consist of a mixture of alcohols in the carbon range above, or can consist of an alcohol having a specific number of carbon atoms within this range.

[0050] A condensation product of one mole of a saturated or unsaturated, straight or branched chain carboxylic acid having from about 8 to about 18 carbon atoms with from about 6 to about 50 moles of ethylene oxide. The acid moiety may consist of a mixture of acids in the carbon atom range defined above, or may consist of an acid having a specific number of carbon atoms within that range. Examples of commercially available compounds of this chemistry are available under the trade names Nopalcol™ manufactured by Henkel Corporation and Lipopeg™ manufactured by Lipo Chemicals, Inc. In addition to the ethoxylated carboxylic acids commonly referred to as polyethylene glycol esters, other alkanoic acid esters formed by reaction with glycerides, glycerin, and polyhydric (sugar or sorbitan / sorbitol) alcohols have application in the present invention in special embodiments, particularly for indirect food additive applications. All of these ester moieties have one or more reactive hydrogen sites on their molecules that can undergo further acylation or ethylene oxide (alkoxide) addition to control the hydrophilicity of these materials.

[0051] Alkyl ethoxylate condensation products of aliphatic alcohols with from about 0 to about 25 moles of ethylene oxide are suitable for use in the present compositions. The alkyl chain of the aliphatic alcohol may be straight or branched, primary or secondary, and generally contains from 6 to 22 carbon atoms.

[0052] Also suitable nonionic surfactants can be alkyl polysaccharide surfactants. These surfactants contain a hydrophobic group containing about 6 to about 30 carbon atoms and a polysaccharide hydrophilic group, such as a polyglycoside, containing about 1.3 to about 10 sugar units. Any reducing sugar containing 5 or 6 carbon atoms can be used, for example, glucose, galactose and galactosyl moieties can be substituted for glucosyl moieties. Optionally, the hydrophobic group is attached at the 2-, 3-, 4-, etc. position to give glucose or galactose rather than a glucoside or galactoside. The intersugar bond can be, for example, between one position of the additional sugar unit and the 2-, 3-, 4-, and / or 6-position of the previous sugar unit.

[0053] Other nonionic surfactants that may be used in the compositions include, but are not limited to, polyoxyethylene glycol alkyl ethers, octaethylene glycol monododecyl ether, pentaethylene glycol monododecyl ether, polyoxypropylene glycol alkyl ethers, glycoside alkyl ethers, decyl glycoside, lauryl glycoside, octyl glycoside, polyoxyethylene glycol octylphenol ether, polyoxyethylene glycol alkylphenol ethers, glycerol alkyl esters, polyglycerol esters, glyceryl laurate, polyoxyethylene glycol sorbitan alkyl esters, sorbitan alkyl esters, dodecyl dimethylamine oxide, block copolymers of polyethylene glycol and polypropylene glycol, poloxamers and polyethoxylated tallow amine (POEA), and combinations thereof.

[0054] In certain embodiments, the non-ionic surfactant is selected from the group consisting of fatty alcohol ethoxylates, alkyl glucosides, alkyl polyglucosides, fatty acid ethoxylates, alkyl phenol ethoxylates, poly(ethylene oxide)-poly(propylene oxide) block copolymers, and combinations thereof. Preferably, the non-ionic surfactant is selected from the group consisting of fatty alcohol ethoxylates, alkyl glucosides, alkyl polyglucosides, alkyl phenol ethoxylates, poly(ethylene oxide)-poly(propylene oxide) block copolymers, and combinations thereof.

[0055] In certain embodiments, the nonionic surfactant is selected from the group consisting of isotridecanol ethoxylates, C9-C11 alcohol ethoxylates, C12-C18 alcohol ethoxylates, and combinations thereof, in certain embodiments, the nonionic surfactant is at least one C9-C11 alcohol ethoxylate.

[0056] "C9-C11 alcohol ethoxylates" or "C12-C18 alcohol ethoxylates" are often commercially available as mixtures. For example, Imbentin® C / 91 / 060 is a commercial product of "C9-11 alcohol ethoxylates" and is available, for example, as "C9-11, branched and linear, ethoxylated" (CAS: [160901-09-7]). Another "C9-C11 alcohol ethoxylate" is available as "alcohol, C9-11, ethoxylated" (CAS: [68439-46-3]).

[0057] In another particular embodiment, the at least one nonionic surfactant comprises at least one C9-C11 alcohol ethoxylate and an additional nonionic surfactant selected from the group consisting of fatty alcohol ethoxylates, alkyl glucosides, alkyl polyglucosides, alkyl phenol ethoxylates, poly(ethylene oxide)-poly(propylene oxide) block copolymers, and combinations thereof.

[0058] <Additional Ingredients> Buffer The disinfectant cleaning composition of the present invention may further comprise a buffering agent. A "buffering agent" is an agent suitable for maintaining the pH level of the composition of the present invention, typically composed of an acid and a (conjugate) base (and vice versa). pH stability may be important for certain compositions formulated according to the present disclosure to ensure adequate antimicrobial efficacy. A suitable buffering agent may be based on at least one organic acid, preferably a carboxylic acid. The at least one carboxylic acid may be acetic acid, glycolic acid, formic acid, citric acid, malic acid, maleic acid, lactic acid, tartaric acid, oxalic acid, combinations thereof used together with the conjugate bases of these acids, or mixtures thereof. Other suitable buffering agents are known to those skilled in the art.

[0059] Typically, less than 1% by weight of these acids is required to achieve the desired pH. Appropriate amounts can be readily determined by one of ordinary skill in the art. Preferably, the buffering agent can be tartaric acid.

[0060] The pH can be adjusted with hydrochloric acid or sodium hydroxide, or with carboxylic acids, preferably tartaric acid.

[0061] Amphoteric surfactants The disinfectant cleaning composition disclosed herein may further comprise an "amphoteric surfactant". An "amphoteric surfactant" is understood to be a surfactant that contains both a basic hydrophilic group and an acidic hydrophilic group, as well as an organic hydrophobic group. These ionic entities can be either anionic or cationic groups as described herein for other types of surfactants. A basic nitrogen and an acidic carboxylate group are typical functional groups used as basic and acidic hydrophilic groups. In a few surfactants, sulfonates, sulfates, phosphonates or phosphates provide the negative charge.

[0062] Another type of amphoteric surfactant is zwitterionic surfactant, for example, betaine surfactant. Zwitterionic surfactant can be considered as a subset of amphoteric surfactant and can contain anionic charge. Zwitterionic surfactant can be broadly described as derivatives of secondary and tertiary amines, derivatives of heterocyclic secondary and tertiary amines, or derivatives of quaternary ammonium, quaternary phosphonium or tertiary sulfonium compounds. Typically, zwitterionic surfactants contain a positively charged quaternary ammonium, or sometimes sulfonium or phosphonium ion, a negatively charged carboxyl group, and an alkyl group. Zwitterions generally contain cationic and anionic groups that can ionize to approximately equal extents in the isoelectric region of the molecule and generate strong "inner salt" attraction between the positive-negative charge centers. Examples of such zwitterionic synthetic surfactants include aliphatic quaternary ammonium, phosphonium derivatives, and sulfonium compounds, where the aliphatic groups can be straight or branched chain, one of the aliphatic substituents contains from 8 to 18 carbon atoms, and one contains an anionic water-solubilizing group, such as a carboxyl, sulfonate, sulfate, phosphate, or phosphonate.

[0063] The amphoteric surfactants used in the compositions according to the invention have no bactericidal activity.

[0064] In certain embodiments, the disinfectant cleaning composition further comprises at least one amphoteric surfactant having an isoelectric point (IEP) higher than the pH of said disinfectant cleaning composition.

[0065] In certain embodiments, the amphoteric surfactant is selected from the group consisting of amine oxides, alkyl betaines, alkyl amidopropyl betaines, and combinations thereof.

[0066] In certain embodiments, the amphoteric surfactant may include cocoamidopropyl betaine.

[0067] In certain embodiments, the amphoteric surfactant is selected from the group consisting of decyl betaine, myristyl betaine, palmityl betaine, lauryl betaine, cetyl betaine, stearyl betaine, coco dimethyl carboxymethyl betaine ("coco betaine"), cocoamidoethyl betaine, cocoamidopropyl betaine, lauramidopropyl betaine, myristylamidopropyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl α-carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, lauryl bis-(2-hydroxyethyl) carboxymethyl betaine, stearyl bis-(2-hydroxypropyl) carboxymethyl betaine, oleyl dimethyl γ-carboxypropyl betaine, lauryl bis-(2-hydroxypropyl) α-carboxyethyl betaine, cocoamidopropyl dimethyl betaine, and combinations thereof.

[0068] In certain embodiments, the amphoteric surfactant may include a polymeric betaine.

[0069] In certain embodiments, the amphoteric surfactant is selected from the group consisting of amine oxides, alkyl betaines, alkyl amidopropyl betaines, and combinations thereof, preferably the amphoteric surfactant is selected from the group consisting of N-alkyl (C6-18)-N,N-dimethylamine-N-oxides, octyl dimethylamine oxide, decyl dimethylamine oxide, lauryl dimethylamine oxide, cocoalkyl dimethylamine oxide, myristyl dimethylamine oxide, octyl dimethylamine oxide, decyl dimethylamine oxide, lauryl dimethylamine oxide, isoalkyl dimethylamine oxide, tetradecyl dimethylamine oxide, cetyl dimethylamine oxide, and combinations thereof.

[0070] In certain embodiments, at least one amphoteric surfactant is an N-alkyl(C6-18)-N,N-dimethylamine-N-oxide.

[0071] Chelating Agents The disinfectant cleaning composition disclosed herein may further comprise a chelating agent. As used herein, the term "chelating agent" can be understood as a molecule that can coordinate (i.e., bind) metal ions commonly found in water sources to prevent the metal ions from interfering with the action of other components. Suitable chelating agents are known to those skilled in the art. Examples of chelating agents include phosphonic acids and phosphonates, phosphates, aminocarboxylates and their derivatives, pyrophosphates, ethylenediamine and ethylenetriamine derivatives, hydroxy acids, and mono-, di-, and tricarboxylates and their corresponding acids. In certain embodiments, the composition does not comprise phosphate.

[0072] Preferred chelating agents form calcium-chelating agent complexes having a stability constant (expressed in logarithmic form) of about 5.5 or greater. The calcium chelating agent stability constant (K) is a measure of the stability of the calcium chelating agent complex (CaL) formed by the reaction of calcium ion (Ca) with the chelating agent (L) in aqueous solution.

[0073] The chelating agent may, for example, be an acetic acid derivative selected from the group consisting of ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), and tetrasodium L-glutamate N,N-diacetate (GLDA).

[0074] Chelating agents may serve to bind other metal ions that may adversely affect the effectiveness of the disinfecting components in the composition. In addition, chelating agents may also aid in removing soils and / or preventing soils from redepositing on the disinfecting composition during use.

[0075] The disinfecting cleaning composition may comprise said at least one chelating agent in an amount of 0.5% to 30% by weight, preferably 1.0% to 10% by weight, based on the total weight of the composition.

[0076] If the disinfectant cleaning composition is in a diluted ready-to-use form, the amount of chelating agent is correspondingly less, for example 0.005% to 0.3% by weight, preferably 0.01% to 0.10% by weight, based on the total weight of the ready-to-use composition.

[0077] In certain embodiments, the disinfectant cleaning composition comprises at least one chelating agent, preferably selected from the group comprising EDTA, methylglycine diacetate (MGDA), GLDA, NTA, β-alanine diacetate (β-ADA), imidodisuccinic acid (IDHA), citrate, gluconate, polystyrene sulfonate, and combinations thereof.

[0078] In a preferred embodiment, the at least one chelating agent is selected from the group including EDTA, MGDA, GLDA, and combinations thereof.

[0079] At least one chelating agent may be in the form of a free acid or its corresponding salt, preferably in the form of its sodium salt.

[0080] In certain embodiments, the disinfectant cleaning composition comprises methylglycine diacetic acid trisodium salt (MGDA-Na3, Trilon M).

[0081] Optional Further Ingredients The disinfectant cleaning composition may include further optional ingredients, including but not limited to fragrances, product colors, corrosion inhibitors, additional surfactants, dispersants, stabilizers, rheology modifiers, carriers, preservatives, bleaching agents, and the like. Exemplary corrosion inhibitors include, for example, organophosphorus compounds and blends of organophosphorus compounds with polymeric components. Product colors may be included to change the appearance of the composition. Fragrances or perfumes that may be included in the composition include, for example, terpenoids such as citronellol, aldehydes such as amylcinnamaldehyde, jasmine such as C1S-jasmine or jasmal, vanillin, and the like. Product colors and fragrances may be added provided that they do not interfere with the function of the composition and may aid in the identification of the composition.

[0082] Any of the above mentioned further components may be present in the disinfectant cleaning composition of the invention, whether the composition is in the form of a concentrate or in a diluted ready-to-use form (see below).

[0083] <Ready-to-use (RTU) form of disinfectant cleaning composition> The disinfectant cleaning composition of the present invention may be diluted to provide a ready-to-use (RTU) form thereof ("RTU composition").

[0084] The compositions of the present invention can be diluted in a single dilution or in stages to provide "ready-to-use disinfectant cleaning compositions" ("RTU compositions").

[0085] The composition of the present invention can be diluted with any suitable amount of water. Terms such as "1:10", "1:100", "1:200", "1:500" are referred to as "dilution factors". In each of these dilution factors, the numerator "1" refers to the number of parts of the disinfectant cleaning composition, and the other numbers (e.g., 10, 100, 200, or 500) refer to the total number of parts of each dilution with water. For example, a disinfectant cleaning composition having a dilution factor of 1:1000 can be diluted with 1 part of the disinfectant cleaning composition with 1000 parts of water. In a preferred embodiment, 1 part of the disinfectant cleaning composition is diluted with 50 to 500 parts of water. More preferably, the disinfectant cleaning composition is diluted with 100 or 200 parts of water for use.

[0086] Providing the disinfectant cleaning composition of the present invention for subsequent dilution can be advantageous when it is desired to package and ship the disinfectant cleaning composition instead of the diluted ready-to-use disinfectant cleaning composition.The ready-to-use disinfectant cleaning composition can be made available when the ready-to-use disinfectant cleaning composition is intended to be applied directly to a surface to provide cleaning and disinfection.For example, a disinfectant cleaning composition for use on glass can be referred to as a ready-to-use composition when it is intended to be applied directly to a glass surface to clean and disinfect.

[0087] Therefore, the present disclosure further provides a ready-to-use composition comprising the disinfectant cleaning composition of the invention diluted with 1 to 1000 parts water, preferably 50 to 500 parts water, or 100 or 200 parts water.

[0088] In RTU form, the disinfectant cleaning composition has a pH of 8.5-12, preferably a pH of 8.5-10.5, more preferably a pH of 9-10.

[0089] In certain embodiments, the disinfectant cleaning composition comprises at least one triamine antimicrobial agent in an amount of 0.001% to 0.5% by weight, preferably 0.005% to 0.1% by weight, more preferably 0.01% to 0.25% by weight, and most preferably 0.05% to 0.1% by weight, based on the total weight of the composition in ready-to-use diluted form.

[0090] In certain embodiments, the disinfectant cleaning composition comprises at least one pH-dependent anionic surfactant in an amount of 0.001% to 1.0% by weight, preferably 0.005% to 0.2% by weight, more preferably 0.01% to 0.1% by weight, and most preferably 0.015% to 0.05% by weight, based on the total weight of the composition in ready-to-use diluted form.

[0091] In certain embodiments, the disinfectant cleaning composition comprises 10% to 50% by weight, preferably 15% to 35% by weight, 17.5% to 30% by weight, more preferably 20% to 25% by weight of said at least one pH-dependent anionic surfactant, based on the total weight of surfactant contained in said composition in ready-to-use diluted form.

[0092] In certain embodiments, the disinfectant cleaning composition comprises at least one non-ionic surfactant in an amount of 0.005% to 0.5% by weight, preferably 0.01% to 0.2% by weight, more preferably 0.02% to 0.1% by weight, based on the total weight of the composition in ready-to-use diluted form.

[0093] Any combination of the above is contemplated, for example, exemplary described embodiments are as follows:

[0094] In certain embodiments, the disinfectant cleaning composition has a pH of 8.5 to 10.5 and is in the form of a ready-to-use composition comprising: (a) the at least one triamine antimicrobial agent in an amount of 0.001% to 0.5% by weight, based on the total weight of the composition in ready-to-use diluted form; (b) said at least one pH-dependent anionic surfactant in an amount of 0.001% to 1.0% by weight, based on the total weight of the composition in ready-to-use diluted form; and (c) said at least one nonionic surfactant in an amount of 0.005% to 0.5% by weight, based on the total weight of the composition in ready-to-use diluted form.

[0095] In certain embodiments, the disinfectant cleaning composition has a pH of 8.5 to 10.5 and is in the form of a ready-to-use composition comprising: (a) the at least one triamine antimicrobial agent in an amount of 0.01% to 0.25% by weight, based on the total weight of the composition in ready-to-use diluted form; (b) said at least one pH-dependent anionic surfactant in an amount of 0.01% to 0.1% by weight, based on the total weight of the composition in ready-to-use diluted form; and (c) said at least one nonionic surfactant in an amount of 0.01% to 0.2% by weight, based on the total weight of the composition in ready-to-use diluted form.

[0096] In certain embodiments, the disinfectant cleaning composition has a pH of 8.5 to 10.5 and is in the form of a ready-to-use composition comprising: (a) said at least one triamine antimicrobial agent in an amount of 0.05% to 0.1% by weight, based on the total weight of the composition in ready-to-use diluted form; (b) said at least one pH-dependent anionic surfactant in an amount of 0.015% to 0.05% by weight, based on the total weight of the composition in ready-to-use diluted form; and (c) said at least one nonionic surfactant in an amount of 0.02% to 0.1% by weight, based on the total weight of the composition in ready-to-use diluted form.

[0097] In certain embodiments, the disinfectant cleaning composition is in the form of a ready-to-use composition as defined herein above and further comprises at least one chelating agent in an amount of 0.005% to 0.3% by weight, preferably 0.01% to 0.10% by weight, based on the total weight of the composition in ready-to-use form.

[0098] In certain embodiments, the disinfectant cleaning composition is in the form of a ready-to-use composition as defined herein above and further comprises at least one amphoteric surfactant in an amount of 0.001% to 0.15% by weight, preferably 0.007% to 0.04% by weight, based on the total weight of the composition in ready-to-use form.

[0099] In certain embodiments, the disinfectant cleaning composition is in the form of a ready-to-use composition as defined herein above, and further comprises at least one non-aqueous solvent in an amount of 0.01% to 0.1% by weight, preferably 0.01% to 0.05% by weight, based on the total weight of the ready-to-use form of the composition. The solvent may be an organic solvent, and may include, but is not limited to, isopropyl alcohol, glycerin, propylene glycol, ethanol, poly(ethylene glycol), DL-1,2-isopropylidene glycerol, mineral oil, paraffin oil, benzene, petroleum distillates, naphtha, acetone, methyl ethyl ketone, toluene, n-propyl bromide, and trichloroethylene (TCE).

[0100] In certain embodiments, the disinfectant cleaning composition is in the form of a ready-to-use composition as defined above and further comprises DL-1,2-isopropylideneglycerol.

[0101] In certain embodiments, the disinfectant wash further comprises DL-1,2-isopropylideneglycerol.

[0102] Although non-aqueous solvents may be present, the disinfectant cleaning composition of the invention may be essentially free, and preferably free, of non-aqueous solvents and / or quaternary ammonium compounds.

[0103] The use of essentially only water and small amounts of triamine-based antimicrobial agents makes the disinfectant cleaning composition of the invention less harmful to the environment and / or allows it to be applied to many solvent-labile surfaces, such as coated materials that are sensitive to solvents and / or abrasion.

[0104] As used herein, "substantially free" means that the composition may contain very small amounts of each component, e.g. less than 10% by weight in disinfectant cleaning compositions and less than 0.1% by weight in the RTU form of the composition, or preferably less than 0.05%, 0.03%, 0.01%, 0.005% or 0.003% by weight of the RTU form of the composition.

[0105] In a diluted ready-to-use disinfectant cleaning composition (RTU composition), non-aqueous solvents may be present in the RTU disinfectant cleaning composition in an amount of less than 0.1 wt.-%, preferably less than 0.05 wt.-%, more preferably less than 0.03 wt.-%, and most preferably the RTU disinfectant cleaning composition is completely free of any non-aqueous solvents.

[0106] In the disinfectant cleaning composition, the non-aqueous solvent is present in an amount of less than 10% by weight, preferably less than 5% by weight, more preferably less than 3% by weight. In certain embodiments, the disinfectant cleaning composition does not contain any non-aqueous solvent at all.

[0107] In diluted ready-to-use disinfectant cleaning compositions (RTU compositions), biocidally active quaternary ammonium compounds may only be present in amounts of less than 0.01% by weight, preferably less than 0.005% by weight, more preferably less than 0.003% by weight. However, it is preferred that RTU disinfectant cleaning compositions do not contain any biocidally active quaternary ammonium compounds.

[0108] Further embodiments of the present invention In one embodiment, the present invention provides a method for the preparation of a method for the treatment of a pulmonary arthritis, comprising the steps of: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant A disinfectant cleaning composition comprising: It is in a ready-to-use form with a pH of 8.5 to 10.5, The composition is provided wherein at least one pH dependent anionic surfactant has an isoelectric point (IEP) greater than pH 0 and less than the pH of said disinfectant cleaning composition.

[0109] In one embodiment, the present invention provides a method for the preparation of a method for the treatment of a pulmonary arthritis, comprising the steps of: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant A disinfectant cleaning composition comprising: having a pH of 8.5 to 12, and at least one pH-dependent anionic surfactant having an isoelectric point (IEP) greater than pH 0 and less than the pH of said disinfectant cleaning composition; The present invention provides a composition, wherein the at least one triamine antimicrobial agent is selected from the group consisting of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine, N-(3-aminopropyl)-N-decyl-1,3-propanediamine, N-(3-aminopropyl)-N-tetradecyl-1,3-propanediamine, and combinations thereof, preferably N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine. Optionally, the composition includes a buffer. Optionally, the composition has a ratio of the total amount of the triamine antimicrobial agent to the total amount of surfactant between 1:1 and 1:4.

[0110] In one embodiment, the present invention provides a method for the preparation of a pharmaceutical composition comprising the steps of: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant A disinfectant cleaning composition in the form of an RTU composition comprising: having a pH of 8.5 to 10.5, and at least one pH-dependent anionic surfactant having an isoelectric point (IEP) greater than pH 0 and less than the pH of said disinfectant cleaning composition; The present invention provides a composition, wherein the at least one triamine antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine. The RTU composition may include N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine in an amount of up to 0.15% by weight, preferably 0.1% by weight, based on the total weight of the composition. Optionally, the RTU composition includes a buffer. Optionally, the RTU composition has a ratio of the total amount of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine to the total amount of surfactant between 1:1 and 1:4.

[0111] In one embodiment, the present invention provides a method for the preparation of a pharmaceutical composition comprising the steps of: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant A disinfectant cleaning composition comprising: It has a pH of 8.5 to 12. the at least one triamine antimicrobial agent is selected from the group consisting of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine, N-(3-aminopropyl)-N-decyl-1,3-propanediamine, N-(3-aminopropyl)-N-tetradecyl-1,3-propanediamine, or combinations thereof; the at least one pH dependent anionic surfactant is selected from the group consisting of alkyl carboxylates, alkyl ether carboxylates, alkyl propionates, alkyl ether propionates, amino acid based surfactants, and combinations thereof; The at least one nonionic surfactant is selected from the group consisting of β-alanine, N-(2-carboxyethyl) N-cocoalkyl derivatives, sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate, sodium N-(2-carboxyethyl)-N-octyl-β-alaninate, β-alanine N-(2-carboxyethyl) N-tallow alkyl derivatives, sodium cocoyl alaninate, sodium lauroyl alaninate, sodium N-dodecanoyl-L-alaninate, and combinations thereof.

[0112] Optionally, the composition comprises a buffer.

[0113] The at least one buffering agent may comprise at least one organic acid, preferably the organic acid is a carboxylic acid preferably selected from the group consisting of acetic acid, glycolic acid, formic acid, citric acid, malic acid, maleic acid, lactic acid, tartaric acid, oxalic acid, and combinations thereof.

[0114] In one embodiment, the present invention provides the following: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant and having a pH of 8.5 to 12, the at least one triamine antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine; the at least one pH dependent anionic surfactant is selected from the group consisting of alkyl carboxylates, alkyl ether carboxylates, alkyl propionates, alkyl ether propionates, amino acid based surfactants, and combinations thereof; Provided is a disinfectant cleaning composition, wherein the at least one non-ionic surfactant is selected from the group consisting of β-alanine, N-(2-carboxyethyl) N-cocoalkyl derivatives, sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate, sodium N-(2-carboxyethyl)-N-octyl-β-alaninate, β-alanine N-(2-carboxyethyl) N-tallow alkyl derivatives, sodium cocoyl alaninate, sodium lauroyl alaninate, sodium N-dodecanoyl-L-alaninate, and combinations thereof.

[0115] Optionally, the composition comprises a buffer.

[0116] The at least one buffering agent may comprise at least one organic acid, preferably the organic acid is a carboxylic acid preferably selected from the group consisting of acetic acid, glycolic acid, formic acid, citric acid, malic acid, maleic acid, lactic acid, tartaric acid, oxalic acid, and combinations thereof.

[0117] In one embodiment, the present invention provides the following: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant and having a pH of 8.5 to 12, the at least one triamine antimicrobial agent is selected from the group consisting of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine, N-(3-aminopropyl)-N-decyl-1,3-propanediamine, N-(3-aminopropyl)-N-tetradecyl-1,3-propanediamine, or combinations thereof; the at least one pH dependent anionic surfactant is at least one amino acid based surfactant; Provided is a disinfectant cleaning composition, wherein the at least one non-ionic surfactant is selected from the group consisting of β-alanine, N-(2-carboxyethyl) N-cocoalkyl derivatives, sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate, sodium N-(2-carboxyethyl)-N-octyl-β-alaninate, β-alanine N-(2-carboxyethyl) N-tallow alkyl derivatives, sodium cocoyl alaninate, sodium lauroyl alaninate, sodium N-dodecanoyl-L-alaninate, and combinations thereof.

[0118] Optionally, the composition comprises a buffer.

[0119] The at least one buffering agent comprises at least one organic acid, preferably the organic acid is a carboxylic acid, preferably selected from the group consisting of acetic acid, glycolic acid, formic acid, citric acid, malic acid, maleic acid, lactic acid, tartaric acid, oxalic acid, and combinations thereof.

[0120] In one embodiment, the present invention provides the following: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant and having a pH of 8.5 to 12, the at least one triamine antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine; the at least one pH dependent anionic surfactant is at least one amino acid based surfactant; the at least one nonionic surfactant is selected from the group consisting of β-alanine, N-(2-carboxyethyl) N-cocoalkyl derivatives, sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate, sodium N-(2-carboxyethyl)-N-octyl-β-alaninate, β-alanine N-(2-carboxyethyl) N-tallow alkyl derivatives, sodium cocoyl alaninate, sodium lauroyl alaninate, sodium N-dodecanoyl-L-alaninate, and combinations thereof; Provided is a disinfectant cleaning composition, wherein the at least one buffering agent comprises at least one organic acid, preferably the organic acid is a carboxylic acid, preferably selected from the group consisting of acetic acid, glycolic acid, formic acid, citric acid, malic acid, maleic acid, lactic acid, tartaric acid, oxalic acid, and combinations thereof.

[0121] In one embodiment, the present invention provides the following: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant and having a pH of 8.5 to 12, the at least one triamine antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine; the at least one pH dependent anionic surfactant is selected from the group consisting of alkyl alaninates, alkyl glutamates, alkyl sarcosinates, alkyl glycinates, alkyl aspartates, and combinations thereof; Provided is a disinfectant cleaning composition, wherein the at least one non-ionic surfactant is selected from the group consisting of β-alanine, N-(2-carboxyethyl) N-cocoalkyl derivatives, sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate, sodium N-(2-carboxyethyl)-N-octyl-β-alaninate, β-alanine N-(2-carboxyethyl) N-tallow alkyl derivatives, sodium cocoyl alaninate, sodium lauroyl alaninate, sodium N-dodecanoyl-L-alaninate, and combinations thereof.

[0122] Optionally, the composition comprises a buffer.

[0123] The at least one buffering agent comprises at least one organic acid, preferably the organic acid is a carboxylic acid, preferably selected from the group consisting of acetic acid, glycolic acid, formic acid, citric acid, malic acid, maleic acid, lactic acid, tartaric acid, oxalic acid, and combinations thereof.

[0124] In one embodiment, the present invention provides the following: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant and having a pH of 8.5 to 12, the at least one triamine antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine; the at least one pH dependent anionic surfactant is at least one amino acid based surfactant; A disinfectant cleaning composition is provided, wherein the at least one non-ionic surfactant is beta sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate.

[0125] Optionally, the composition comprises a buffer.

[0126] The at least one buffering agent comprises at least one organic acid, preferably the organic acid is a carboxylic acid, preferably selected from the group consisting of acetic acid, glycolic acid, formic acid, citric acid, malic acid, maleic acid, lactic acid, tartaric acid, oxalic acid, and combinations thereof.

[0127] In one embodiment, the present invention provides the following: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant and having a pH of 8.5 to 12, the at least one triamine antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine; the at least one pH dependent anionic surfactant is selected from the group consisting of alkyl alaninates, alkyl glutamates, alkyl sarcosinates, alkyl glycinates, alkyl aspartates, and combinations thereof; A disinfectant cleaning composition is provided, wherein the at least one non-ionic surfactant is beta sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate.

[0128] Optionally, the composition comprises a buffer.

[0129] The at least one buffering agent comprises at least one organic acid, preferably the organic acid is a carboxylic acid, preferably selected from the group consisting of acetic acid, glycolic acid, formic acid, citric acid, malic acid, maleic acid, lactic acid, tartaric acid, oxalic acid, and combinations thereof.

[0130] In one embodiment, the present invention provides the following: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant and having a pH of 8.5 to 12, the at least one triamine antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine; at least one pH dependent anionic surfactant is an alkyl alaninate; A disinfectant cleaning composition is provided, wherein the at least one non-ionic surfactant is beta sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate.

[0131] Optionally, the composition comprises a buffer.

[0132] The at least one buffering agent comprises at least one organic acid, preferably the organic acid is a carboxylic acid, preferably selected from the group consisting of acetic acid, glycolic acid, formic acid, citric acid, malic acid, maleic acid, lactic acid, tartaric acid, oxalic acid, and combinations thereof.

[0133] In one embodiment, the present invention provides the following: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant, and (c) at least one nonionic surfactant and having a pH of 8.5 to 12, the at least one triamine antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine; the at least one pH-dependent anionic surfactant is sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate; A disinfectant cleaning composition is provided, wherein the at least one non-ionic surfactant is beta sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate.

[0134] Optionally, the composition comprises a buffer.

[0135] The at least one buffering agent comprises at least one organic acid, preferably the organic acid is a carboxylic acid, preferably selected from the group consisting of acetic acid, glycolic acid, formic acid, citric acid, malic acid, maleic acid, lactic acid, tartaric acid, oxalic acid, and combinations thereof.

[0136] In one embodiment, the present invention provides the following: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant; (c) at least one nonionic surfactant, and (d) at least one buffer; and having a pH of 8.5 to 12, the at least one triamine antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine; the at least one pH dependent anionic surfactant is at least one alkyl alaninate; the at least one nonionic surfactant is beta sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate; A disinfectant cleaning composition is provided, wherein the at least one buffering agent comprises at least one organic acid, preferably the organic acid is tartaric acid.

[0137] In one embodiment, the present invention provides the following: (a) at least one triamine antimicrobial agent; (b) at least one pH dependent anionic surfactant; (c) at least one nonionic surfactant, and (d) at least one buffer; and having a pH of 8.5 to 12, the at least one triamine antimicrobial agent is N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine; the at least one pH-dependent anionic surfactant is at least one sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate; the at least one nonionic surfactant is beta sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate; A disinfectant cleaning composition is provided, wherein the at least one buffering agent comprises at least one organic acid, preferably the organic acid is tartaric acid.

[0138] <Use> The disinfectant cleaning compositions disclosed above can be used to clean a variety of hard surfaces. The term "cleaning" refers to the process used to promote or assist in soil removal, bleaching, microbial population reduction, and any combination thereof.

[0139] All hard surfaces and all non-human or non-animal surfaces can be cleaned with the disinfectant cleaning composition of the present invention.

[0140] Such surfaces include, but are not limited to, those installed in industries including dairies, homes, health care facilities, swimming pools, canneries, food processing plants, restaurants, hospitals, public facilities, and secondary oil recovery.

[0141] Suitable surfaces that can be treated with the compositions of the present invention include, but are not limited to, any hard surface such as those made from glass, metals such as aluminum or stainless steel, ceramics, stone such as granite or marble, plastic or polymeric materials, and the like.

[0142] The composition of the present invention provides good cleaning efficiency for both greasy and particulate soils. Oil and greasy soils adhere to the (floor) surface and cause discoloration by attracting and holding dry soil. This type of soil can be classified as the worst type of soil. Colorings, for example from food or beverages, can be absorbed into the (floor) surface and cause permanent stains if left untreated. Particulate soils adhere to the surface as a result of van der Waals and related interactions between the contaminant and the surface.

[0143] The disinfectant cleaning composition can be used in any suitable industry or field.For example, the disinfectant cleaning composition can be used in the food and beverage field.The disinfectant cleaning composition can include, for example, hard surface cleaners, hand sanitizers, sterilizing or high-level disinfectant cleaning compositions, pre-disinfectant cleaners for instruments, etc. EXAMPLES

[0144] [Example 1] The biocidal and cleaning efficacy of the compositions of the present invention are determined as outlined below and compared with the comparative "Composition A", which differs from the compositions of the present invention only in the nature of the surfactant used in said composition. The compositions of the present invention contain a pH-dependent anionic surfactant, whereas the comparative composition uses a permanent anionic surfactant. As can be derived from Figures 1 and 2, the cleaning performance of all compositions is better than water and comparable to each other. However, the compositions of the present invention show significantly higher biocidal efficacy despite the presence of anionic surfactant.

[0145] [Composition of the present invention] Table 1 shows exemplary compositions of the present invention and their components.

[0146] Composition I (RTU CI) is a ready-to-use (RTU) form of the composition of the invention.

[0147] Composition C I.1 and Composition C II.1 are compositions of the invention, the specification "1:100 concentrate" means that the composition can be diluted with 100 parts of water for use.

[0148] Composition I.2 (C I.2) and Composition II.2 (C II.2) are compositions of the invention, the specification "1:200 concentrate" means that each composition can be diluted with 200 parts of water for use.

[0149] [Table 1]

[0150] [Comparative composition] Table 2 shows the composition of the comparative "Composition A."

[0151] Comparative "Composition A" is a "ready-to-use" composition diluted with 100 parts water to contain 0.068% by weight of a triamine antimicrobial agent (N-(3-aminopropyl)-N-dodecylpropane-1.3-diamine), 0.03% by weight of a nonionic surfactant, and 0.014% by weight of an anionic surfactant (i.e., a permanent anionic surfactant, rather than a pH dependent surfactant as used in the compositions of the present invention described above).

[0152] [Table 2]

[0153] <Biocidal effectiveness> Biocidal efficacy was tested by using the EN13697 European Standard Surface Disinfection Test under I&I Contamination Conditions, which is a quantitative non-porous surface test to evaluate the bactericidal and / or fungicidal activity of chemical disinfectants used in the food, industrial, domestic and institutional sectors.

[0154] Table 3 shows the biocidal efficacy of the RTU CI of the present invention and diluted (RTU) forms of Composition A containing the same amounts of the same amine-based antimicrobial agent against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Enterococcus hirae, and Candida albicans. Results are quoted as mean log reduction and percent pass. Each measurement was performed with 10 replicates per test point.

[0155] [Table 3]

[0156] Composition RTU CI, representative of compositions of the present invention, demonstrated greater surface disinfection efficacy than RTU comparative composition A (diluted to have the same level of antimicrobial activity in both treatments). The requirement to achieve a pass rate in this test is a ≥ 4 log reduction against bacteria (represented by Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Enterococcus hirae) and a ≥ 3 log reduction against yeast (represented by Candida albicans) after a specified period of time.

[0157] Below these reduction rates the composition will fail against the particular microorganism. It is well known that the antimicrobial efficacy of a disinfectant always increases with increasing contact time with the target microorganism.

[0158] The data shown in Table 3 indicate that composition RTU CI according to the invention is superior to RTU comparative composition A against gram-positive bacteria (Staphylococcus aureus) and against yeast (Candida albicans) as a log reduction of > 4 for bacteria is achieved after 2 minutes (bacteria) or 4 minutes (yeast). Additionally, composition RTU CI achieved a similar log reduction of gram-negative bacteria (Pseudomonas aeruginosa) compared to RTU composition A, even though composition I had a shorter contact time (2 minutes vs. 4 minutes). Thus, composition RTU CI demonstrated superior efficacy against gram-negative bacteria compared to composition A.

[0159] <Cleaning effectiveness> The cleaning efficacy of the composition according to the invention, water, and comparative compositions A and B was carried out on hard surfaces using an Elcometer scrub tester (Elcometer model 1720 abrasion and cleanability tester using a scrub speed of 37 cycles / min.) The hard surfaces were prepared by baking a layer of food soil onto the surface at 170°C for 45 minutes.

[0160] The method is based on 20 scrubs with an Elcometer Scrub Tester, used with a universal material clamp equipped with a cloth, delivering 5ml of the test product.

[0161] FIG. 1 shows the hard surface after cleaning with the above test composition and water.

[0162] FIG. 2 is a column chart showing the results of the cleaning test described in FIG. 1, comparing the cleaning efficacy of a composition of the invention (Composition I) to water and comparative disinfectant cleaning compositions A and B on hard surfaces.

[0163] As can be derived from these Figures 1 and 2, the cleaning performance of Composition I and Compositions A and B was better than water and comparable to each other.< / ph>

Claims

1. 1. A disinfectant cleaning composition comprising: (a) at least one triamine antimicrobial agent; (b) at least one pH-dependent anionic surfactant, and (c) at least one nonionic surfactant Including, having a pH of 8.5 to 12; 1. A disinfectant cleaning composition, wherein said at least one pH dependent anionic surfactant has an isoelectric point (IEP) above pH 0 and below the pH of said disinfectant cleaning composition.

2. 2. The disinfectant cleaning composition of claim 1, wherein the at least one triamine antimicrobial agent is selected from the group consisting of N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine, N-(3-aminopropyl)-N-decyl-1,3-propanediamine, N-(3-aminopropyl)-N-tetradecyl-1,3-propanediamine, and combinations thereof.

3. 2. The disinfectant cleaning composition of claim 1, wherein said at least one pH dependent anionic surfactant is selected from the group consisting of alkyl carboxylates, alkyl ether carboxylates, alkyl propionates, alkyl ether propionates, amino acid based surfactants, and combinations thereof.

4. the nonionic surfactant is selected from the group consisting of fatty alcohol ethoxylates, alkyl glucosides, alkyl polyglucosides, fatty acid ethoxylates, alkyl phenol ethoxylates, poly(ethylene oxide)-poly(propylene oxide) block copolymers, and combinations thereof; and / or 2. The disinfectant cleaning composition of claim 1, wherein said nonionic surfactant is selected from the group consisting of isotridecanol ethoxylates, C9 to C11 alcohol ethoxylates, C12 to C18 alcohol ethoxylates, and combinations thereof.

5. optionally further comprising at least one amphoteric surfactant; the amphoteric surfactant is selected from the group consisting of amine oxides, alkyl betaines, alkylamidopropyl betaines, and combinations thereof; and / or 2. The disinfectant cleaning composition of claim 1, wherein said amphoteric surfactant is selected from the group consisting of N-alkyl(C6-18)-N,N-dimethylamine-N-oxides, octyldimethylamine oxide, decyldimethylamine oxide, lauryldimethylamine oxide, cocoalkyldimethylamine oxide, myristyldimethylamine oxide, octyldimethylamine oxide, decyldimethylamine oxide, lauryldimethylamine oxide, isoalkyldimethylamine oxides, tetradecyldimethylamine oxide, and cetyldimethylamine oxide.

6. 10. The disinfectant cleaning composition of claim 1, further comprising at least one buffering agent.

7. 7. The disinfectant cleaning composition of claim 6, wherein said buffering agent comprises at least one organic acid, said organic acid being a carboxylic acid.

8. 2. The disinfectant cleaning composition according to claim 1, wherein the ratio of the total amount of the at least one triamine based antimicrobial agent to the total amount of surfactants in the composition is between 1:1 and 1:

4.

9. 2. The disinfectant cleaning composition according to claim 1, comprising 10% to 50% by weight of said at least one pH-dependent anionic surfactant, based on the total weight of surfactants included in the composition.

10. The disinfectant cleaning composition of claim 1, further comprising at least one chelating agent.

11. 2. The disinfectant cleaning composition of claim 1, essentially free of biocidally active quaternary ammonium compounds and / or essentially free of non-aqueous solvents.

12. 10. The disinfectant cleaning composition of claim 1, in a diluted "ready to use" ("RTU") form comprising the disinfectant cleaning composition and water in a ratio of 1:1 to 1:1000.

13. 13. The disinfectant cleaning composition according to claim 12, having a pH of 8.5 to 10.

5.

14. (a) the at least one triamine antimicrobial agent in an amount of 0.05% to 0.1% by weight based on the total weight of the composition; (b) said at least one pH-dependent anionic surfactant in an amount of 0.015% to 0.05% by weight based on the total weight of the composition; (c) said at least one nonionic surfactant in an amount of 0.02% to 0.1% by weight based on the total weight of the composition; 13. The disinfectant cleaning composition of claim 12, comprising:

15. 10. Use of the disinfectant cleaning composition according to claim 1 for disinfecting and / or cleaning hard surfaces.

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