Mutants of paenibacillus and methods for use thereof

JP2025060869A5Pending Publication Date: 2025-10-22BAYER CROPSCIENCE LP
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Patent Information

Application Number
JP2024229785
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2018-05-14
Filing Date
2024-12-26
Publication Date
2025-10-22

AI Technical Summary

Technical Problem

When the existing Paenibacillus strains produce the antifungal active substance fusalicidin, the high viscosity of the culture medium leads to difficulty in growth of the bioreactor and complex downstream processing, and are costly and work-intensive.

Method used

Through chemical treatment and high-throughput screening technology, the Paenibacillus strain is modified, the production of fusalicidin is enhanced, and the viscosity of the culture medium is reduced through visual screening, improving the adaptability of large-scale growth and downstream treatment.

Benefits of technology

Strains with reduced viscosity and increased production of fusalicidin were successfully created, which simplified the large-scale culture and processing process, and reduced costs and workload.

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Abstract

To provide methods for producing and identifying Paenibacillus sp. strains with enhanced fungicidal activity and processability.SOLUTION: The present invention provides a composition comprising a biologically pure culture of a Paenibacillus sp. strain comprising a mutant DegU lacking a functional receiver domain or a functional DNA binding domain and / or a mutant DegS lacking a functional single binding domain or a functional ATPase domain with decreased viscosity in a liquid culture. Also provided is a method of identifying a Paenibacillus sp. mutant derivative strain with decreased viscosity in a liquid culture compared to a Paenibacillus sp. parental strain with a visual screen for mutant with a non-mucoid morphology.SELECTED DRAWING: Figure 1
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