Pesticidal composition comprising chlorantraniliprole, chlorfenapyr and other insecticide

Abstract

The present invention provides a composition comprising of chlorantraniliprole, chlorfenapyr and at least one insecticidal compound selected from the group consisting of cyano imidamides, meta diamides, isoxazolines, and oxadiazines. The invention further provides a process of preparation thereof.

Description

PESTICIDAL COMPOSITION COMPRISING CHLORANTRANILIPROLE, CHLORFENAPYR AND OTHER INSECTICIDETECHNICAL FIELD

[0001] The present invention relates to a synergistic pesticidal composition. In particular, the present invention relates to a synergistic pesticidal composition comprising chlorantraniliprole, chlorfenapyr, and at least one more insecticide.BACKGROUND

[0002] Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.

[0003] One of the major problems that most farmers face today is the excessive damage caused to the crops by the pests. Approximately, 20 to 40% of global crop production is lost to pests annually. It has been estimated that the amount of food that pests consume is sufficient to feed more than one billion people [Journal of Experimental Botany, Volume 62, Issue 10, June 2011, Pages 3251-3261], Therefore, pesticides including insecticides are heavily used to manage pests and dangerous insects that cause a massive harm to the crops.

[0004] Various pesticides and mixture of pesticides are known in the literature for pest control. However, extensive and prolonged use of various compositions having one or two pesticidal active ingredients has resulted in pest resistance. This has necessitated the application of more concentrated formulations, resulting in adverse effects on plant health, crop yield and also leads to increased costs. With the onset of resistance to certain pests, there is a need for combination of active ingredients that decreases chances of pest resistance and improves the spectrum of pest control and improved insecticidal activity.

[0005] CN102113516A discloses insecticidal composition comprising the combination two active ingredients, chlorantraniliprole and other selected from lambda cypermethrin, cyhalothrin, chlorpyrifos, profenofos, trichlorfon, emamectin benzoate, spinosad,tebufenozide, hexaflumuron, chlorfenapyr, pyridaben, acetamiprid, and cartap with mass ratio of the two ingredients being 1 :60 - 60: 1.

[0006] CN101703050A discloses insecticidal composition comprising chlorantraniliprole and at least one compound selected from organic phosphorus insecticide: chlorpyrifos, quinalphos, profenofos and triazophos. The composition can prevent and treat various crop such as the ice borer, rice planthopper, beet armyworm, diamondback moth.

[0007] There exists a need for improved insecticidal composition that is effective against insect pests of different crops and serves as a useful tool for managing resistance, has a broad spectrum, is environmentally safe, has a reduced dosage, stable over a long period of time for effective application on crops, and has a lower frequency of application than existing formulations.OBJECTIVES

[0008] An objective of the present invention is to provide a synergistic pesticidal composition having improved insecticidal activity.

[0009] A further objective of the present invention is to provide a pesticidal composition comprising chlorantraniliprole, chlorfenapyr, and at least one insecticide selected from group of cyano imidamides, meta diamides, isoxazolines, and oxadiazines.

[0010] Another obj ective of the present invention is to provide a method for preparation of the pesticidal composition.

[0011] Yet another objective of the present invention is to provide a pesticidal composition with a broad spectrum of insect control.

[0012] Still another objective of the present invention is to provide a pesticidal formulation that has good storage stability.

[0013] Some or all these and other objectives of the invention may be achieved by way of the invention described hereinafter.SUMMARY

[0013] The following presents a simplified summary of the subject matter in order to provide a basic understanding of some aspects of subject matter embodiments. This summary is not an extensive overview of the subject matter. It is not intended to identify key / critical elements of the embodiments or to delineate the scope of the subject matter. Its sole purpose is to present some concepts of the subject matter in a simplified form as a prelude to the more detailed description that is presented later. A full appreciation of the various aspects of the embodiments disclosed herein can be gained by taking the entire specification, claims, drawings, and abstract as a whole.

[0014] The present invention in another aspect provides a composition comprising chlorantraniliprole, chlorfenapyr, and at least one insecticide selected from group consisting of cyano imidamides, isoxazolines, and oxadiazines.

[0015] The present invention in another aspect provides a composition comprising chlorantraniliprole, chlorfenapyr, and at least one insecticide selected from group consisting of cyano imidamides, isoxazolines, meta diamides, and oxadiazines, and a buffer.

[0016] The present invention in another aspect provides a process of preparation of said pesticidal compositions comprising the steps of homogenizing a mixture comprising chlorantraniliprole, chlorfenapyr, and at least one insecticide selected from group consisting of cyano imidamides, isoxazolines, and oxadiazines; and milling the homogenized mixture to a particle size of below ten microns to obtain the composition.

[0017] The present invention in yet another aspect provides a process for preparation of the composition comprising the steps of homogenizing a mixture comprising a buffer, chlorantraniliprole, chlorfenapyr, at least one insecticide selected from group consisting of cyano imidamides, isoxazolines, meta diamides and oxadiazines; and milling the homogenized mixture to a particle size of below ten microns to obtain the composition.DETAILED DESCRIPTION

[0018] The following description with reference to the accompanying examples is provided to assist in a comprehensive understanding of exemplary embodiments of the invention. It includes various specific details to assist in that understanding but these are to be regarded as merely exemplary. Accordingly, persons skilled in the art will recognize that various changes and modifications to the embodiments described herein can be made without departing from the scope and spirit of the invention. In addition, descriptions of well-known functions and constructions are omitted for clarity and conciseness.

[0019] The terms and words used in the following description are not limited to the bibliographical meanings, but, are merely used by the inventor to enable a clear and consistent understanding of the invention. Accordingly, it should be apparent to the person skilled in the art that the following description of exemplary embodiments of the present invention are provided for illustration purpose only. It is to be understood that the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. It should also be noted that the term “or” is generally employed in its sense including “and / or” unless the content clearly dictates otherwise.

[0020] The definitions provided herein below for the terminologies used in the present disclosure are for illustrative purpose only and in no manner limit, the scope of the present invention disclosed in the present disclosure.

[0021] All technical and scientific phrases or terms used here have the same meanings as those that a person who is skilled in the field of study of the current subject matter would understand. Although other processes and materials similar to or equivalent, to those described herein may be used in the practice of the present invention, the preferred materials and process are described herein.

[0022] The expression of various quantities in terms of “% w / w” or “%” means the percentage by weight, relative to the weight of the total solution or composition unless otherwise specified. The term “active ingredient”, “a.i ” or “active agent” or “actives” used herein refers to the components of the composition responsible for control and killing of pests / insects.

[0023] The term “crop” shall include a multitude of desired crop plants or an individual crop plant. The term “control” means to inhibit the ability of pests to survive, grow, feed and / or reproduce, or to limit the pests related damage or loss in crop plants. To “control” pests may or may not mean killing the insects although, it may mean killing the pests.

[0024] The term “insecticide” as used herein refers to any chemical substance used to destroy / kill, inhibit or otherwise adversely affect the insect pests.

[0025] In an embodiment of the present invention, the active ingredients used in the present composition may be in the form of base or any salt form or ester form of the active which is known in the art.

[0026] The term “synergistic” as used herein, refers to the combined action of two or more active agents blended together and administered conjointly that is greater than the sum of their individual effects.

[0027] The term “plants” refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, stalks, foliage, and fruits. The term “locus” of a plant as used herein is intended to embrace the place on which the plants are growing, where the plant propagation materials of the plants are sown or where the plant propagation materials of the plants will be placed into the soil. The term “plant” herein is also understood to denote generative parts of a plant, such as seeds, vegetative materials such as cutting or tubers, roots, fruits, bulbs, rhizomes and parts of plants, germinated plants and young plants which are to be transplanted after germination or after emergence from the soil. These young plants may be protected before transplantation by total or partial treatment by immersion.

[0028] The problem of insecticide resistance is widespread among commonly available pesticides, particularly concerning the lepidopteran pest Spodoptera exigua. This pest has shown resistance to numerous existing molecules, posing a significant challenge for farmers across various crops such as cotton, chili, soybean, maize, and onion due to its polyphagous nature. The pesticidal composition of the present invention has been developed to address this issue. The composition incorporates pesticides with differentmodes of action from distinct classes to effectively control S. exigua and other lepidopteran pests like Helicoverpa armigera. thereby overcoming resistance concerns associated with single-molecule treatments. The compositions, in particular, demonstrate synergistic effect and provides improved insecticidal activity.

[0029] The composition of the present invention further has a good storage stability, which helps in effective application of insecticides on the crops.THE SYNERGISTIC PESTICIDAL COMPOSITIONS

[0030] The composition of the present invention comprises chlorantraniliprole, chlorfenapyr, and at least one insecticide selected from the group consisting of cyano imidamides, isoxazolines, and oxadiazines.

[0031] The cyano imidamides can be selected from acetamiprid, thiacl oprid or mixtures thereof. The isoxazolines can be selected from fluxametamide, isocycloseram or mixtures thereof. The oxadiazine is indoxacarb.

[0032] In an embodiment of the present invention, the composition of the present invention comprises chlorantraniliprole, chlorfenapyr, and at least one insecticide selected from acetamiprid, fluxametamide, and indoxacarb.

[0033] In an embodiment of the present invention, the insecticidal composition of the present invention comprises chlorantraniliprole, chlorfenapyr, and acetamiprid. In another embodiment of the present invention, the insecticidal composition of the present invention comprises chlorantraniliprole, chlorfenapyr, and fluxametamide. In a preferred embodiment of the present invention, the insecticidal composition of the present invention comprises chlorantraniliprole, chlorfenapyr, and indoxacarb.

[0034] The percentage weight of the constituents of the composition of the present invention comprises 0.01 to 40 % by weight chlorantraniliprole, 0.01 to 50 % by weight chlorfenapyr, and 0.01 to 20 % by weight of at least one insecticide. In a preferred embodiment of the present invention, the composition comprises 0.1 to 25 % by weightchlorantraniliprole, 0.1 to 30 % by weight chlorfenapyr, and 0.1 to 20 % by weight of at least one insecticide. In another preferred embodiment of the present invention, the composition comprises 0.5 to 15 % by weight chlorantraniliprole, 1 to 25 % by weight chlorfenapyr, and 1 to 20 % by weight of at least one insecticide. In a most preferred embodiment of the present invention, the composition comprises 0. 1 to 25 % by weight chlorantraniliprole, 0.1 to 30 % by weight chlorfenapyr, and 0.1 to 20 % by weight indoxacarb.

[0035] The compositions of the present invention comprising chlorantraniliprole, chlorfenapyr, and at least one insecticide display synergistic action towards the pest control and are effective in terms of prolonged pest control in crops. In addition, the compositions of the present invention are also stable over a long period of time.

[0036] In an embodiment, the compositions of the present invention are preferably employed with the auxiliaries conventionally used in the art of formulation to give, for example, capsule suspension (CS), dispersible concentrate (DC), powder for dry seed treatment (DS), emulsifiable concentrate (EC), emulsifiable granule (EG), emulsion water- in- oil (EO), emulsifiable powder (EP), emulsion for seed treatment (ES), emulsion oil-in- water (EW), flowable concentrate for seed treatment (FS), granules (GR), micro-emulsion (ME), Oil dispersion (OD), oil miscible flowable concentrate (OF), oil miscible liquid (OL), oil dispersible powder (OP), suspension concentrate (SC), suspension concentrate for direct application (SD), suspo-emulsion (SE), Water soluble granule (SG), soluble concentrate (SL), spreading oil (SO), water soluble powder (SP), water dispersible granules (WG), wettable powder (WP), water dispersible powder for slurry seed treatment (WS), a mixed formulation of CS and SC (ZC) or a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW).

[0037] In a preferred embodiment, the composition of the present invention is formulated as suspension concentrate.

[0038] In the compositions of the present invention, the active ingredients may be employed in pure form, for example, the solid active ingredients in a specific particle size, or, preferably, together with at least one of the auxiliaries conventionally used in the art of formulation.

[0039] In an embodiment of the present invention, the compositions may comprise one or more inactive auxiliaries selected from the group of carrier(s), surfactant(s), binder(s), disintegrating agent(s), dispersants or dispersing agent(s), wetting agent(s), buffer, thickener(s), biocide(s), preservative(s), anti-freezing agent(s), defoamer(s), solvent(s), adjuvants, and / or stabilizer(s) or a combination thereof.

[0040] A “dispersant”, also known as a dispersing agent, is a substance that adsorbs onto the surface of particles, preserving their dispersion and preventing them from reaggregating. Dispersants are added to an agrochemical composition to aid in particle dispersion and suspension during manufacturing, as well as to ensure particle re-disperse in water in a spray tank. They are a common ingredient in wettable powders, suspension concentrates, and water dispersible granules. Surfactants used as dispersants have the ability to adsorb strongly onto a particle surface and provide a charged or stearic barrier to re-aggregation of particles. The most commonly used surfactants are either anionic, nonionic, or combination thereof.

[0041] Dispersing agents may be selected from the group of, but not limited to, acrylic graft copolymer, alcohols, C9-n-iso-, Cio-rich, ethoxylated, tri styrylphenol ethoxylate phosphate ester, poly(oxy-l,2-ethanediyl), a-sulfo-co-[2,4,6-tris(l-phenylethyl)phenoxy]-, ammonium salt, poly (oxy- 1,2-ethanediyl), a-phosphono-co-2,4,6-tris(l- phenylethyljphenoxy-, alkoxylated alcohol, naphthalene and alkyl naphthalene sulphonic acids formaldehyde condensate, sodium salt. Non-ionic surfactants such as alkyl aryl ethylene oxide condensates and EO-PO block copolymers may be combined with anionic surfactants. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersants. The synthetic polymer exhibits crystal growth inhibition properties. These have very long hydrophobic backbones and a large number of ethylene oxide chains forming the “teeth of a comb” surfactant. These high molecular weight polymers may give long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersants used herein include but not limited to sodium lignosulphonates, poly aryl phenyl ether phosphate, tristyryl phenol ethylated / acrylic graft copolymer / ethoxylated tristryl phenol sulphate, naphthalene sulfonic acid, Sodium dibutylnaphthalenesulphonate,sodium salt condensate with formaldehyde, ethoxylated oleyl cetyl alcohol, polyalkelene glycol ether, ethoxylated fatty alcohol; and graft copolymers or mixtures thereof.

[0042] Examples of anti-freezing agent are polyethylene glycols, mono ethylene glycol, methoxy polyethylene glycols, glycol, propylene glycol, polypropylene glycols, poly butylene glycols, glycerin, ethylene glycol, di ethylene glycol or mixture thereof.

[0043] Suitable adjuvants are vegetable oil (plant, seed or tree) or it’s alkylated or ethoxylated or esterified; the alkylated vegetable oil may be methylated vegetable oil or ethylated vegetable oil; the vegetable oils include olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, com oil, rice bran oil, cotton seed oil, soybean oil, groundnut oil, rapeseed oil, mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil; the alkyl ester of vegetable oils, methyl ester, ethyl ester, propyl ester or butyl ester of vegetable oils, methylated seed oil, polyalkyleneoxide modified polydimethylsiloxane, alkylphenol ethoxylate, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl esters, rapeseed oil butyl esters, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl esters, soybean oil butyl esters, castor oil methyl ester, castor oil ethyl ester, castor oil propyl esters, castor oil butyl esters, cotton seed oil methyl ester, cotton seed oil ethyl ester, cotton seed oil propyl esters, cotton seed oil butyl esters, tall oil fatty acids esters, tallow methyl ester, bio-diesel, mineral oil (aromatic solvents, isoparaffin, base solvent), fatty acid amides (e.g. C1-C3 amines, alkylamines or alkanolamines with Ce- Cis carboxylic acids), fatty acids, alkyl esters of fatty acids, methyl and ethyl oleate, methyl and ethyl soyate, alkyl benzenes and alkylnapthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkylamides and diamides, dialkylene carbonates, ketones and alcohols. The above oil-based adjuvant may be used as solo and mixture thereof.

[0044] Water-based formulations often produce foam during manufacturing processes. Anti-foam chemicals are frequently added during the manufacture stage or before filling into bottles to reduce the tendency to foam. Anti-foaming agents are classified into two types, silicones and non- silicones. Silicones are usually aqueous emulsions of dimethyl polysiloxane. Non-silicone anti- foam agents are water-insoluble oils such as octanol and nonyl, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.

[0045] Defoam er / antifoaming agents are used in agrochemical formulations to prevent foaming during manufacturing and spraying stages. They are typically added to the composition, as foam prevents efficient container filling. Suitable anti -foaming agents may be selected from silicon emulsion based anti-foam agents, siloxane polyalkyleneoxide, trisiloxane ethoxylates, and mixtures thereof.

[0046] A wetting agent is a substance that, when added to a liquid, increases its spreading or penetrating ability by lowering the interfacial tension between the liquid and the surface it is spreading on. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacturing to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates and hence improving the stability of suspension concentrates; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and improve water penetration into water-dispersible granules. Wetting agents used in suspension concentrate, wettable powder, and water dispersible granule formulations include, but not limited to, sodium lauryl sulphate; sodium dioctylsulphosuccinate, alkyl phenol ethoxylates, and aliphatic alcohol ethoxylates or mixtures thereof.

[0047] Anti-microbial agents are used to eliminate or diminish the effect of microorganisms. Examples of anti-microbial agents agent include, but are not limited to, propionic acid and its sodium salt, sorbic acid and its sodium or potassium salts, benzoic acid and its sodium salt, p-hydroxy benzoic acid sodium salt, methyl p -hydroxy benzoate, and biocides such as sodium benzoate, 1,2-benzisothiazoline- 3-one, 2-methyl-4- isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, parahydroxybenzoates or mixtures thereof.

[0048] Thickeners, gelling agents, and viscosity modifier are commonly used in the formulation of suspension concentrates, emulsions, and suspoemulsions to alter the rheology or flow properties of the liquid and to avoid separation and settling of the dispersed particles or droplets. Thickening, gelling, and anti-settling agents are classified as either water-insoluble particles or water-soluble polymers. Clay and silicas may be used for preparing suspension concentrate compositions. These materials include, but are limited to, montmorillonite (e.g., bentonite), magnesium aluminum silicate, andattapulgite. For many years, water-soluble polysaccharides have been used as thickening, and gelling agents. Natural extracts of seeds and seaweed, as well as synthetic derivatives of cellulose or mixtures thereof, are the most often utilized polysaccharides. Guar gum, locust bean gum, Carrageenan, xanthan gum, alginates, methyl cellulose, sodium carboxymethyl cellulose (SCMC), hydroxyethyl cellulose (HEC) or combination thereof are examples of these materials. Other anti-settling agents are based on modified starches, polyacrylates, polyvinyl alcohol, polyethylene oxide or any combination thereof. These auxiliaries can be added depending on the specific requirements of formulations.

[0049] In another embodiment of the present invention, the carriers may be selected from water, organic solvents, inorganic solvents or combination thereof. The carriers may be present in the “Quantum Satis", i.e., Q.S. quantity.

[0050] Stabilizers are used in agrochemical suspensions to prevent the active agrochemicals from crystallizing. Stabilizer can be a buffer. The buffer in the composition of the present invention comprises a mixture of potassium dihydrogen phosphate, sodium hydroxide, and Zinc Ethylenediaminetetraacetic acid (Zn EDTA). The buffer aids in the preparation of a stable suspension concentrate formulation of the present invention. The buffer maintains the required suspensibility of active ingredients in the formulation and prevents the increase in particle sizes, thereby overcoming flowability and viscosity concerns.

[0051] The buffer in the composition of the present invention comprises 0.01 to 8 % potassium dihydrogen phosphate, 0.01 to 8 % sodium hydroxide, and 0.01 to 8 % Zn EDTA. In a preferred embodiment, the buffer is a mixture of 0.1 to 2 % potassium dihydrogen phosphate, 0.01 to 1 % sodium hydroxide, and 0.1 to 2 % Zn EDTA.

[0052] In an embodiment of the present invention, the composition comprises chlorantraniliprole, chlorfenapyr, at least one insecticide selected from the group of cyano imidamides, meta diamides, isoxazolines, and oxadiazines, and a buffer.

[0053] In an embodiment of the present invention, cyano imidamides can be selected from acetamiprid, thiacloprid or mixture thereof; isoxazolines can be selected fromfluxametamide, isocycloseram or mixture thereof; meta diamide is broflanilide; and oxadiazine is indoxacarb.

[0054] In an embodiment of the present invention, composition of the present invention comprises chlorantraniliprole, chlorfenapyr, at least one insecticide selected from the group of acetamiprid, thiacloprid, fluxametamide, isocycloseram, indoxacarb, and the buffer.

[0055] In a preferred embodiment, the composition comprises chlorantraniliprole, chlorfenapyr, indoxacarb, and the buffer.

[0056] In another preferred embodiment, the composition of the present invention comprises 0.1 to 25 % by weight chlorantraniliprole, 0.1 to 30 % by weight chlorfenapyr, and 0.1 to 20 % by weight indoxacarb, 0.1 to 2 % potassium dihydrogen phosphate, 0.01 to 1 % sodium hydroxide, and 0.1 to 2 % Zn EDTA.

[0057] In an embodiment, the composition of the present invention further comprises 0.01 to 15 % by weight dispersing agent, 0.01 to 8 % by weight wetting agent, 0.01 to 8 % by weight anti-foaming agent, 1 to 20 % by weight anti-freezing agent, and 0.01 to 8 % by weight biocide.

[0058] In an embodiment of the present invention, the composition comprises 0.1 to 25 % by weight chlorantraniliprole, 0.1 to 30 % by weight chlorfenapyr, and 0.1 to 20 % by weight indoxacarb, 0.01 to 15 % by weight dispersing agent, 0.01 to 8 % by weight wetting agent, 0.01 to 8 % by weight anti -foaming agent, 1 to 20 % by weight anti-freezing agent, and 0.01 to 8 % by weight biocide.

[0059] In an embodiment of the present invention, the composition comprises 0.1 to 25 % by weight chlorantraniliprole, 0.1 to 30 % by weight chlorfenapyr, and 0.1 to 20 % by weight indoxacarb, 0.01 to 15 % by weight dispersing agent, 0.01 to 8 % by weight wetting agent, 0.01 to 8 % by weight anti -foaming agent, 1 to 20 % by weight anti-freezing agent, 0.01 to 8 % by weight biocide, 0.1 to 2 % potassium dihydrogen phosphate, 0.01 to 1 % sodium hydroxide, and 0.1 to 2 % Zn EDTA.

[0060] Further, one or more auxiliaries can be added to the composition of the present invention in the desired amounts depending on the specific requirements of formulations.

[0061] The plants and parts of plants can be treated with the compositions directly or by action on their environment, habitat or storage area according to customary treatment methods, for example by dipping, spraying, evaporating, atomizing, broadcasting, dusting, wetting, scattering, pouring, brushing-on, seed dressing, immersion, and others. The methods of application are selected to suit the intended aims and the prevailing circumstances.

[0062] A preferred method of application is to apply the compositions to the roots, either directly or through administration to the soil. A particularly preferred method of application is foliar application. It is a technique of feeding plants by applying liquid pesticides directly to the leaves. Plants are able to absorb active ingredients of systematic pesticide to enable better control of insect pest through trans-laminar action through their leaves. Foliar application has been shown to avoid the problem of leaching-out in soils and prompts a quick reaction in the plant.

[0063] In another embodiment of the present invention, the composition of the present invention is especially suitable for controlling representatives of the family Plutellidae, in particular the genus Plutella, especially Plutella xylostella (Diamondback moth), and representatives of the family Noctuidae, especially the genus Spodoptera and Helicoverpa, in particular Spodoptera exigua and Helicoverpa armigera. respectively.

[0064] The compositions of the present invention can control the pests which belong, but not limited to, the class Insecta, and Arachnida. Exemplary pests may include: from the order Lepidoptera, pests such as Acleris spp., Adoxophyes spp., Aegeria spp., Agrotis spp., Alabama argillaceae, Amylois spp., Anticar sia gemmatalis, Archips spp., Argyrotaenia spp., Autographa spp., Busseola fusca, Cadra cautella, Carposina nipponensis, Chilo spp., Choristoneura spp., Clysia ambiguella, Cnaphalocrocis spp., Cnephasia spp., Cochylis spp., Coleophora spp., Crocidolomia spp., Cryptophlebia leucotreta, Crysodeixis includens, Cydia spp., Diatraea spp., Diparopsis castanea, Earias spp., Elasmopalpus spp., Ephestia spp., Eucosma spp., Eupoecilia ambiguella, Euproctis spp., Euxoa spp., Grapholita spp., Hedya nubiferana, Heliothis spp., Hellula undalis,Hyphantria cunea, Keiferia ly coper sicella, Leucopter a scitella, Lithocollethis spp., Lobesia botrana, Lymantria spp., Lyonetia spp., Malacosoma spp., Mamestra brassicae, Manduca sexta, Operophtera spp., Ostrinia nubilalis, Pammene spp., Pandemis spp., Panolis flammea, Pectinophora gossypiella, Phthorimaea operculella, Pieris rapae, Pieris spp., Plutella xylo Stella, Prays spp., Scirpophaga spp., Sesamia spp., Sparganothis spp., Spodoptera spp., Synanthedon spp., Thaumetopoea spp., Tortrix spp., Trichoplusia ni and Yponomeuta spp.,' from the order Thysanoptera, pests such as Frankliniella spp., Hercinothrips spp., Taeniothrips spp., Thrips palmi, Thrips tabaci and Scirtothrips aurantii; from the order Heteroptera, pests such as Dichelops melacanthus, Distantiella theobroma, Dysdercus spp., Euchistus spp., Eurygaster spp., Leptocorisa spp., Nezara spp., Piesma spp., Rhodnius spp., Sahlbergella singularis, Scotinophara spp. and Triatoma spp.; from the order Homoptera, insect pests such as Aleurothrixus floccosus, Aleyrodes brassicae, Aonidiella spp., Aphididae, Aphis spp., Aspidiotus spp., Bemisia tabaci, Ceroplaster spp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Coccus hesperidum, Empoasca spp., Er iosoma larigerum, Erythroneura spp., Gascardia spp., Laodelphax spp., Lecanium corni, Lepidosaphes spp., Macrosiphus spp., Myzus spp., Nephotettix spp., Nilaparvata spp., Paratoria spp., Pemphigus spp., Pianococcus spp., Pseudaulacaspis spp., Pseudococcus spp., Psylla spp., Pulvinaria aethiopica, Quadraspidiotus spp., Rhopalosiphum spp., Saissetia spp., Scaphoideus spp., Schizaphis spp., Sitobion spp., Trialeurodes vaporariorum, Trioza erytreae and Unaspis citri from the order Hymenoptera, insect pests such as Acromyrmex, Athalia rosae, Atta spp., Cephus spp., Diprion spp., Diprionidae, Gilpinia polytoma, Hoplocampa spp., Lasius spp., Monomorium pharaonis, Neodiprion spp., Solenopsis spp. and Vespa spp.; from the order Diptera, insect pests such as Antherigona soccata, Bibio hortulanus, Ceratitis spp, Chrysomyia spp., Culex spp., Cuterebra spp., Dacus spp., Delia spp., Drosophila melanogaster, Liriomyza spp., Melanagromyza spp., Orseolia spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp., Rhagoletis pomonella, Sciara spp.; from the order Acarina, pests such as Acarus siro, Aceria sheldoni, Aculus schlechtendali, Amblyomma spp., Argas spp., Brevipalpus spp., Bryobia praetiosa, Calipitrimerus spp., Chorioptes spp., Dermanyssus gallinae, Eotetranychus carpini, Eriophyes spp., Hyalomma spp., Olygonychus pratensis, Ornithodoros spp., Panonychus spp., Phyllocoptruta spp. (such as Phyllocoptruta oleivora), Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Tarsonemus spp. and Tetranychus spp.

[0065] The compositions of the present invention can be used for controlling pests of the above-mentioned type which occur in particular on plants, especially in crop plants and ornamentals, in agricultural, in horticulture and in forests, or on parts of such plants, such as fruits, flowers, foliage, stalks, tubers or roots.

[0066] In an embodiment of the present invention, the crops on which the compositions of the present invention may be used include, but not limited to, com, rice, wheat, barley, rye, oat, sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower, sugar cane, tobacco, etc.; solanaceous vegetables such as eggplant, tomato, pimento, pepper, potato, etc., cucurbit vegetables such as cucumber, pumpkin, zucchini, water melon, melon, squash, etc.; cruciferous vegetables such as radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc.; asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc.; liliaceous vegetables such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, parsley, celery, parsnip, etc.; chenopodiaceous vegetables such as spinach, Swiss chard, etc.; lamiaceous vegetables such as Perilla frutescens, mint, basil, etc, strawberry, sweet potato, Dioscorea japonica, colocasia, etc., flowers, foliage plants, turf grasses; pome fruits such apple, pear, quince, etc.; stone fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry fruit, apricot, prune, etc.; citrus fruits such as orange, lemon, rime, grapefruit, etc.; nuts such as chestnuts, walnuts, hazelnuts, almond, pistachio, cashew nuts, macadamia nuts, etc.; berries such as blueberry, cranberry, blackberry, raspberry, etc.; grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc.; trees other than fruit trees; tea, mulberry, flowering plant; trees such as ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus, poplar, Judas tree, Liquidambar formosana. plane tree, zelkova, Japanese arborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxus cuspidate, etc.PREPARATION OF THE SYNERGISTIC PESTICIDAL COMPOSITION

[0067] The present invention discloses a method of preparation of the synergistic pesticidal compositions. In the absence of auxiliaries, the compositions can be prepared by mixing, grinding and / or compressing mixture of active ingredients, for example to a specific particle size. In the presence of at least one auxiliary, the composition can beprepared by intimately mixing and / or grinding the mixture of active ingredients with one or more auxiliaries.

[0068] In an embodiment, the present invention also provides a method of preparing the suspension concentrate formulation, which involves adding anti-foaming agent, antifreezing agent, and dispersing agent to the demineralized water or buffer and stirring the mixture to obtain a first mixture. To the first mixture, active ingredients are added followed by homogenization to obtain a second mixture. The second mixture is then milled to achieve particle sizes below 10 microns, which is followed by addition of viscosity modifier and biocide under constant stirring to obtain a uniform composition. Further, one or more other auxiliaries can be added as per the requirements of the formulation.

[0069] In an embodiment of the present invention, the milling step in the process can be achieved by bead milling, ball milling, pebble milling, rod milling, tower milling, and SAG (semi-autogenous grinding) milling.

[0070] In another embodiment of the present invention, the milled mixture can be further homogenized to avoid any lumps in the composition. In another embodiment, homogenization or stirring step of the mixture of active ingredients in the process can be performed for a duration of 15 minutes to 60 minutes.

[0071] Other formulations of the compositions of the present invention can be prepared as known to a person skilled in the art.Examples

[0072] The present subject matter is further enumerated and substantiated by way of working examples as described hereinafter with reference to the system incorporated in the present subject matter.1. Formulation / Composition and Preparatory Examples

[0073] Various formulations have been prepared and are tabulated in Tables 1.1 and 1.2. Suspension Concentrate (SC) Formulations IE1 to IE14 and Water DispersibleGranules (WG) IE15 to IE17 are inventive formulations of the present invention. These formulations have been prepared in accordance with the below-mentioned steps. Formulations IE1 to IE12 were prepared in buffer, and IE13 and IE14 were prepared in the water.Suspension concentrate formulations

[0074] The SC formulations of the present invention provided in table 1.1 were prepared as follows- silicon defoamer was added to the demineralized water or buffer. The buffer was obtained by adding potassium dihydrogen phosphate, sodium hydroxide, and Zn EDTA into the demineralized water, and mixing thoroughly; next, acrylic graft copolymer and propylene glycol were added to the above solution and stirred continuously for 15-20 minutes;- the active ingredients were incorporated in the mixture followed by homogenization for 30 minutes; milling of the above mixture was initiated and the mixture was passed through the bead mill via wet grinding to achieve particle sizes below 10 microns;- the milled material was transferred into a second post-feed vessel;- xanthan gum solution, biocide, and the remaining water were added into the milled mass;- the entire mixture was homogenized using a homogenizer for 20 minutes until no lumps of xanthan gum are observed;- the material was packed into suitable pack using a standard sieve of 36 mesh to obtain the suspension concentrate.Table 1.1. Suspension Concentrate (SC) FormulationsWater dispersible granules

[0075] The Water Dispersible Granules of the present invention provided in table 1.2 were prepared as follows: all the raw materials including the active ingredients as per the specified formulations were combined in a pre-blending vessel followed by mixing thoroughly for 15 minutes;- the mixed mass was transferred to an air classifier mill for grinding;- the ground mass was moved to the post-blender and blended for 30 minutes; a measured quantity of the milled material was mixed with water in a blender for 15-20 minutes;- the resulting water-powder mixture was transferred into the granulator for granulation, followed by drying to obtain water dispersible granules of the present invention.

[0076] Table 1.2. Water Dispersible Granules (WG)* a.i. is active ingredient Q.S. is Quantum Satis2. Biological Examples:

[0077] “Synergism” [is] an interaction of two or more factors such that the effect when combined is greater than the predicted effect based on the response to each factor applied separately. If the observed response of the combination is greater than the expected (or predicted) response, or stated conversely, if the difference between the observed and expected response is greater than zero, then the combination is said to be synergistic or unexpectedly effective. (Colby, S.R., Weeds, 1967(15), p.20-22). The Colby method required only a single dose of each herbicide applied alone and the mixture of both doses. However, following formula was used to calculate the expected activity of mixtures containing three active ingredients, A, B and C:Expected (E)™where:A= observed efficacy of active ingredient A B = observed efficacy of active ingredient B C = observed efficacy of active ingredient CIf, Observed Value / Expected Value >1 = Good synergistic effect.Treatment Details:

[0078] The experiments reported in this section were conducted using a randomized complete block design with three replications, each having a plot area of 25 m2The test samples, according to the treatment schedule, were applied at pest appearance using 500 Liters of water per hectare with a knapsack sprayer.

[0079] Pre-count pest population on the crop was recorded before the spray application. Pest counts were recorded by randomly selecting five plants per replication and noting the larval population for each replication. Observations were recorded on the 3rd, 7th, and 10thdays after the spray application (DAA).

[0080] Field evaluation studies were done for the inventive and comparative compositions to evaluate the bio-efficacy of the compositions.2.1. Bio-efficacy studies in Chili crop against Spodoptera exigua.IE18 is the inventive composition of the present invention. CE1 to CE12 are comparative examples.

[0081] Treatment Details:

[0082] Experiment Details:

[0083] Table 2.1: Effectiveness of the composition against Chili Spodoptera exigua.DAA (days after application), Pre count (Number of pest population before spray)

[0084] Table 2.2: Synergistic effect of different compositions against ChiliSpodoptera exigua 7DAA.Results:

[0085] The results indicate a significant reduction in the population of Spodoptera exigua when treated with the inventive composition of the present invention IE18, Chlorantraniliprole 4.5% + Chlorfenapyr 15% + Indoxacarb 7% SC. The pest control by inventive composition IE18 is better than individual pesticide or binary combination of the pesticides and displays the synergistic effect.2.2. Bio-efficacy studies in Cabbage against Diamondback moth.

[0086] Experiment Details:

[0087] Table 2.3: Effectiveness of different compositions against CabbageDiamondback moth.DAA (days after application), Pre count (Number of pest population before spray)

[0088] Table 2.4: Synergistic effect of compositions against CabbageDiamondback moth 7DAA.Results:

[0089] The results indicate a significant reduction in the population of Diamondback moth when treated with the inventive composition of the present invention IE18, Chlorantraniliprole 4.5% + Chlorfenapyr 15% + Indoxacarb 7% SC. The pest control by inventive composition IE18 is better than individual pesticide or binary combination of the pesticides and displays the synergistic effect.2.3. Bio-efficacy studies in Chickpea crop against pod borer.

[0090] Experiment Details:

[0091] Table 2.5: Effectiveness of different compositions against Chickpea pod borer.DAA (days after application), Pre count (Number of pest population before spray)

[0092] Table 2.6: Synergistic effect of different compositions against Chickpea pod borer 7DAA.Results:

[0093] The results indicate a significant reduction in the population of Chickpea pod borer when treated with the composition of the present invention IE18, Chlorantraniliprole 4.5% + Chlorfenapyr 15% + Indoxacarb 7% SC. The pest control by inventive composition IE18 is better than individual pesticide or binary combination of the pesticides and displays the synergistic effect.2.4. Bio-efficacy studies in Chili crop against Spodoptera exigua.IE19 and IE20 are the inventive compositions of the present invention. CE1 to CE12 are comparative examples.

[0094] Treatment Details:

[0095] Experiment Details:

[0096] Table 2.7: Effectiveness of different compositions against Chili Spodoptera exigua.DAA (days after application), Pre count (Number of pest population before spray)

[0097] Table 2.8: Synergistic effect of different compositions against ChiliSpodoptera exigua 7DAA.Results:

[0098] The results indicate a significant reduction in the population of Spodoptera exigua when treated with the inventive compositions of the present invention IE19, Chlorantraniliprole 4.5% + Chlorfenapyr 15% + Broflanilide 1.5% SC and IE20, Chlorantraniliprole 4.5% + Chlorfenapyr 15% + Fluxametamide 4% SC. The pest control by inventive compositions IE19 and IE20 is better than individual pesticide or binary combination of the pesticides and displays the synergistic effect. 2.5. Bio-efficacy studies in Cabbage against Diamondback moth.

[0099] Experiment Details:

[0100] Table 2.9: Effectiveness of different compositions against Diamondback moth.DAA (days after application), Pre count (Number of pest population before spray)

[0101] Table 2.10: Synergistic effect of different compositions against Diamondback moth 7DAA.Results:

[0102] The results indicate a significant reduction in the population of Diamondback moth when treated with the inventive compositions of the present invention IE19, Chlorantraniliprole 4.5% + Chlorfenapyr 15% + Broflanilide 1.5% SC and IE20, Chlorantraniliprole 4.5% + Chlorfenapyr 15% + Fluxametamide 4% SC. The pest control by inventive compositions IE19 and IE20 is better than individual pesticide or binary combination of the pesticides and displays the synergistic effect.2.6. Bio-efficacy studies in Chickpea crop against pod borer.

[0103] Experiment Details:

[0104] Table 2.11: Effectiveness of different compositions against Chickpea pod borer.

[0105] Table 2.12: Synergistic effect of different compositions against Chickpea pod borer 7DAA.DAA (days after application), Pre count (Number of pest population before spray)Results:

[0106] The results indicate a significant reduction in the population of Chickpea pod borer when treated with the inventive compositions of the present invention IE19, Chlorantraniliprole 4.5% + Chlorfenapyr 15% + Broflanilide 1.5% SC and IE20, Chlorantraniliprole 4.5% + Chlorfenapyr 15% + Fluxametamide 4% SC. The pest control by inventive compositions IE19 and IE20 is better than individual pesticide or binary combination of the pesticides and displays the synergistic effect.3. PHYSIOCHEMICAL PROPERTIES AND STORAGE STABILITY OBSERVATIONS OF COMPOSITIONS

[0107] Physiochemical properties and storage stability data were recorded for compositions IE1, IE10, IE11, IE12, IE13, and IE14 of the present invention and the observations are in the tables below.

[0108] Table 3.1. Physiochemical Properties of Formulation IE1, IE10, IE11, andIE 12.

[0109] Table 3.2. Storage Stability Observation of Formulation IE1.*AHS is Accelerated Stability Test

[0110] Table 3.3. Storage Stability Observation of Formulation IE10.

[0111] Table 3.4. Storage Stability Observation of Formulation IE11.

[0112] Table 3.5. Storage Stability Observation of Formulation IE12.

[0113] Table 3.6. Analytical Observation of Formulations IE13 and IE14.*n.m. - not measured

[0114] The data collated in the above tables show that the buffer (comprising potassium dihydrogen phosphate, sodium hydroxide, and Zn EDTA) has improved the storage stability of the present composition. The SC Formulations IE13 and IE14 prepared without the buffer showed a decrease in the suspensibility of chlorfenapyr, ranging from 94% to 50%, which posed challenges in achieving stabilization. A decrease in suspensibility indicates that theactive ingredient is less well-distributed in the suspension, which leads to uneven application, and hence can result in poor performance of the product.

[0115] Formulation IE13 in Table 3.6 displayed increased particle size, resulting in decreased flowability and high viscosity. Low flowability makes the suspension difficult to handle and mix and high viscosity adversely affects the ease of application and potentially causing issues with spraying or spreading the product. Formulation IE14 has issues such as the formation of hard cakes (Table 3.6). Hard cake formation indicates that the suspension is not maintaining a consistent flow and is prone to clumping. This can make it difficult to mix or use the product, leading to uneven application. Further, hard cake formation suggests instability in the formulation and a sign of improper grinding or dispersion, which affects the overall stability of the product.

[0116] Additionally, crystallization issues were observed within four days of conducting the Accelerated stability tests (AHS) test for formulation IE14 (Table 3.6). Crystallization can affect the uniformity of the active ingredient, leading to inconsistent efficacy. Crystals may alter the intended release profile or activity of the active ingredient. The formation of crystals is a sign of instability in the formulation, which may compromise the overall product quality. AHS conducted over 14 days indicated that the active ingredients remained stable for formulation IE13; however, particle size increased, which adversely affects flowability of the SC formulation.

[0117] To address these challenges with Suspension Concentrates, a buffer comprising potassium dihydrogen phosphate, sodium hydroxide, and Zn EDTA is incorporated in the composition of the present invention. The inclusion of zinc EDTA not only contributes to formulation stability but also helps in crop greening effect and improving the overall crop health. A robust and stable formulation is achieved by carefully balancing the suspensibility of active ingredients and optimizing particle sizes through addition of the buffer, thereby overcoming flowability and viscosity concerns. These favorable parameters such as smaller particle sizes and lower viscosity can be observed for IE1, IE10, IE11, and IE12 in Tables 3.2, 3.3, 3.4, and 3.5, respectively. Further, crystallization issues have been effectively mitigated. This approach significantly improves application effectiveness and offers distinct advantages in agricultural practices.

[0118] Further, the analytical parameters were also recorded for Water Dispersible Granules (WG) IE15 of the present invention. Details are in the below tables.

[0119] Table 3.7. Analytical Observation of WG Formulation IE15.

[0120] Although the disclosure of compositions has been described in connection with the embodiment of the present disclosure illustrated in the accompanying examples, it is not limited thereto. It will be apparent to those skilled in the art that various substitutions, modifications and changes may be made thereto without departing from the scope and spirit of the disclosure.

Claims

We Claim:

1. A composition, comprising:- chlorantraniliprole;- chlorfenapyr; and- at least one insecticide selected from group consisting of cyano imidamides, isoxazolines, and oxadiazines.

2. The composition as claimed in claim 1, wherein the cyano imdamides are selected from acetamiprid, thiacloprid or mixtures thereof; isoxazolines are selected from fluxametamide, isocycloseram or mixtures thereof; and oxadiazine is indoxacarb.

3. The composition as claimed in claim 2, wherein said insecticide is indoxacarb.

4. The composition as claimed in claim 1, wherein- chlorantraniliprole is present in an amount of 0.01 to 40 % by weight;- chlorfenapyr is present in an amount of 0.01 to 50 % by weight; and- the insecticide is present in an amount of 0.01 to 20 % by weight.

5. The composition as claimed in claim 1, wherein- chlorantraniliprole is present in an amount of 0.1 to 25 % by weight;- chlorfenapyr is present in an amount of 0.1 to 30 % by weight; and- the insecticide is present in an amount of 0.1 to 20 % by weight.

6. The composition as claimed in claim 1, comprising a buffer, wherein said buffer comprises:- 0.01 to 8 % by weight potassium dihydrogen phosphate;- 0.01 to 8 % by weight sodium hydroxide; and- 0.01 to 8 % by weight Zn ED TA.

7. A composition, comprising:- chlorantraniliprole;- chlorfenapyr;- at least one insecticide selected from group consisting of cyano imidamides, isoxazolines, meta diamides, and oxadiazines; and- a buffer.

8. The composition as claimed in claim 7, wherein the cyano imdamides are selected from acetamiprid, thiacloprid or mixtures thereof; isoxazolines are selected from fluxametamide, isocycloseram or mixtures thereof; meta diamide is broflanilide; and oxadiazine is indoxacarb.

9. The composition as claimed in claim 8, wherein the buffer comprises:- 0.01 to 8 % by weight potassium dihydrogen phosphate;- 0.01 to 8 % by weight sodium hydroxide; and- 0.01 to 8 % by weight Zn ED TA.

10. The composition as claimed in claim 9, wherein the buffer comprises:- 0.1 to 2 % by weight potassium dihydrogen phosphate;- 0.01 to 1 % by weight sodium hydroxide; and- 0.1 to 2 % by weight Zn EDTA.

11. The composition as claimed in claims 1 or 7, further comprising a dispersing agent, a wetting agent, a viscosity modifier, an anti-foaming agent, an anti-freezing agent, a buffer, a biocide, a preservative, a stabilizer, a carrier, a protective colloid, an adhesive, a thickener, an adjuvant, or mixture thereof.

12. The composition as claimed in claim 11, wherein the dispersing agent is present in an amount of 0.01 to 15 % by weight; the wetting agent is present in an amount of 0.01 to 8 % by weight; the anti -foaming agent is present in an amount of 0.01 to 8 % by weight; the anti-freezing agent is present in an amount of 1 to 20 % by weight; the viscosity modifier is present in an amount of 0.01 to 8% by weight; and the biocide is present in an amount of 0.01 to 8 % by weight.

13. The composition as claimed in claim 7, comprising- 0.1 to 25 % chlorantraniliprole;- 0.1 to 30 % chlorfenapyr;- 0.1 to 20 % indoxacarb; and- the buffer, comprising a mixture of 0.1 to 2 % by weight potassium dihydrogen phosphate; 0.01 to 1 % by weight sodium hydroxide; and 0.1 to 2 % by weight Zn EDTA.

14. The composition as claimed in claims 11 to 12, wherein the dispersing agent is selected from group consisting of acrylic graft copolymer, alcohols, C9-n-iso-, Cio-rich, ethoxylated, tristyrylphenol ethoxylate phosphate ester, poly(oxy-l,2-ethanediyl), a-sulfo-co-[2,4,6-tris(l- phenylethyl)phenoxy]-, ammonium salt, poly(oxy-l,2-ethanediyl), a-phosphono-co- 2,4,6-tris(l-phenylethyl)phenoxy-, alkoxylated alcohol, naphthalene and alkyl naphthalene sulphonic acids formaldehyde condensate, sodium salt, alkyl aryl ethylene oxide condensates, sodium lignosulphonates, sodium dibutylnaphthalenesulphonate, poly aryl phenyl ether phosphate, tristyryl phenol ethylated / acrylic graft copolymer / ethoxylated tristryl phenol sulphate, naphthalene sulfonic acid, sodium salt condensate with formaldehyde, ethoxylated oleyl cetyl alcohol, polyalkelene glycol ether, ethoxylated fatty alcohol, EO-PO block copolymers, graft copolymers or combination thereof; the wetting agent is selected from group consisting of sodium lauryl sulphate, sodium dioctyl sulphosuccinate, alkyl phenol ethoxylates, and aliphatic alcohol ethoxylates or combination thereof; the viscosity modifier is selected from group consisting of guar gum, locust bean gum, carrageenan, xanthan gum, alginates, methyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose or combination thereof;the anti-foaming agent is selected from group consisting of dimethyl polysiloxane, siloxane polyalkyleneoxide, trisiloxane ethoxylates or combination thereof; the anti-freezing agent is selected from group consisting of polyethylene glycols, mono ethylene glycol, methoxy polyethylene glycols, glycol, propylene glycol, polypropylene glycols, polybutylene glycols, glycerin, ethylene glycol, diethylene glycol or combination thereof; the biocide is selected from group consisting of sodium benzoate, 1,2- benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4- isothiazolin-3-one, potassium sorbate, parahydroxybenzoates or combination thereof; and the carrier is selected from group consisting of water, organic solvent, inorganic solvent or combination thereof.

15. A process for preparation of the composition as claimed in claim 1, comprising the steps of: homogenizing a mixture comprising chlorantraniliprole, chlorfenapyr, and at least one insecticide selected from group consisting of cyano imidamides, isoxazolines, and oxadiazines; and milling the homogenized mixture to a particle size of below ten microns to obtain the composition.

16. The process as claimed in claim 15, comprising the steps of: providing an anti-foaming agent, a dispersing agent, and an antifreezing agent to form a first mixture; adding chlorantraniliprole, chlorfenapyr, and at least one insecticide selected from group consisting of cyano imidamides, isoxazolines, and oxadiazines to the first mixture followed by homogenization to obtain a second mixture; milling the second mixture to a particle size of below ten microns; andadding a viscosity modifier, a biocide, and a carrier to the milled mixture.

17. A process for preparation of the composition as claimed in claim 7, comprising the steps of homogenizing a mixture comprising a buffer, chlorantraniliprole, chlorfenapyr, at least one insecticide selected from group consisting of cyano imidamides, isoxazolines, meta diamides and oxadiazines; and milling the homogenized mixture to a particle size of below ten microns to obtain the composition.

18. The process as claimed in claim 17, comprising the steps of mixing an anti-foaming agent, a dispersing agent, and an anti-freezing agent in the buffer to form a first mixture; adding chlorantraniliprole, chlorfenapyr, and at least one insecticide selected from group consisting of cyano imidamides, isoxazolines, meta diamides, and oxadiazines to the first mixture followed by homogenization to obtain a second mixture; milling the second mixture to a particle size of below ten microns; and adding a viscosity modifier, a biocide, and a carrier to the milled mixture.

19. The process as claimed in claim 15 or 17, wherein the cyano imdamides are selected from acetamiprid, thiacloprid or mixtures thereof; isoxazolines are selected from fluxametamide, isocycloseram or mixtures thereof; meta diamide is broflanilide; and oxadiazine is indoxacarb.

20. The process as claimed in claim 17 or 18, wherein the buffer comprises0.01 to 8 % by weight potassium dihydrogen phosphate;0.01 to 8 % by weight sodium hydroxide; and0.01 to 8 % by weight Zn EDTA.

21. The process as claimed in claim 17 or 18, wherein the buffer comprises0.1 to 2 % by weight potassium dihydrogen phosphate;0.01 to 1 % by weight sodium hydroxide; and0.1 to 2 % by weight Zn EDTA.

22. The process as claimed in claim 16 or 18, wherein the dispersing agent is selected from group consisting of acrylic graft copolymer, alcohols, C9-n-iso-, Cio-rich, ethoxylated, tristyrylphenol ethoxylate phosphate ester, poly(oxy-l,2-ethanediyl), a-sulfo-co-[2,4,6-tris(l- phenylethyl)phenoxy]-, ammonium salt, poly(oxy-l,2-ethanediyl), a-phosphono-co- 2,4,6-tris(l-phenylethyl)phenoxy-, alkoxylated alcohol, naphthalene and alkyl naphthalene sulphonic acids formaldehyde condensate, sodium salt, alkyl aryl ethylene oxide condensates, sodium lignosulphonates, sodium dibutylnaphthalenesulphonate, poly aryl phenyl ether phosphate, tristyryl phenol ethylated / acrylic graft copolymer / ethoxylated tristryl phenol sulphate, naphthalene sulfonic acid, sodium salt condensate with formaldehyde, ethoxylated oleyl cetyl alcohol, polyalkelene glycol ether, ethoxylated fatty alcohol, EO-PO block copolymers, graft copolymers or combination thereof; the wetting agent is selected from group consisting of sodium lauryl sulphate, sodium dioctyl sulphosuccinate, alkyl phenol ethoxylates, and aliphatic alcohol ethoxylates or combination thereof; the viscosity modifier is selected from group consisting of guar gum, locust bean gum, carrageenan, xanthan gum, alginates, methyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose or combination thereof; the anti-foaming agent is selected from group consisting of dimethyl polysiloxane, siloxane polyalkyleneoxide, trisiloxane ethoxylates or combination thereof; the anti-freezing agent is selected from group consisting of polyethylene glycols, mono ethylene glycol, methoxy polyethylene glycols, glycol, propyleneglycol, polypropylene glycols, polybutylene glycols, glycerin, ethylene glycol, diethylene glycol or combination thereof; the biocide is selected from group consisting of sodium benzoate, 1,2- benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4- isothiazolin-3-one, potassium sorbate, parahydroxybenzoates or combination thereof; and the carrier is selected from group consisting of water, organic solvent, inorganic solvent or combination thereof.

23. A method of controlling pests comprising applying the composition as claimed in claims 1 or 7 to plants.

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