Nucleic acid delivery carrier composition and use thereof

By optimizing the proportion and combination of components in lipid nanoparticles, the packaging and delivery efficiency of mRNA is improved, and the problem of low mRNA delivery efficiency in the prior art is solved, thereby achieving efficient and non-toxic protein expression.

WO2025108355A1 Publication Date: 2025-05-30SHENZHEN RHEGEN BIOTECHNOLOGY CO LTD +1
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Patent Information

Application Number
PCT/CN2024/133415
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-11-21
Filing Date
2024-11-21
Publication Date
2025-05-30

AI Technical Summary

Technical Problem

Existing lipid nanoparticles (LNPs) are difficult to efficiently deliver mRNA to target sites in protein replacement therapy, resulting in lower delivery efficiency.

Method used

A nucleic acid delivery vector composition is provided, including a specific molar ratio of cationic lipids, assisted phospholipids, cholesterol and PEG-conjugated lipids, to improve the encapsulation and delivery efficiency of mRNA by optimizing the proportion and combination of these components.

Benefits of technology

Efficient and non-toxic mRNA delivery is achieved, significantly improving the ability of mRNA to reach the targeted site and enhancing the efficiency of protein expression.

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Abstract

A nucleic acid delivery carrier composition and use thereof. The composition comprises a cationic lipid, a helper phospholipid, cholesterol, and a PEG-conjugated lipid having a molar ratio of (30-50):(4-16):(31.5-63.5):(0.5-2.5); the helper phospholipid is one or a combination of two of DOPE and DSPC, and the cationic lipid is one or a combination of more structures selected from the following structures. The composition can wrap mRNA used for protein expression to treat related deficiency diseases, is efficient, and does not have toxic side effects.
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