Liquid composition containing salt of ascorbyl palmitate phosphate ester, and method for preserving salt of ascorbyl palmitate phosphate ester

Abstract

This liquid composition containing a salt of an ascorbyl palmitate phosphate ester contains a dihydric alcohol and a salt of the ascorbyl palmitate phosphate ester. The content of the dihydric alcohol is higher than 90.00% by mass.

Description

Liquid composition containing a salt of ascorbyl palmitate phosphate and method for storing a salt of ascorbyl palmitate phosphate

[0001] The present invention relates to a liquid composition containing a salt of ascorbyl palmitate phosphate and a method for preserving the salt of ascorbyl palmitate phosphate. This application claims priority to Japanese Patent Application No. 2024-011853, filed on January 30, 2024, the contents of which are incorporated herein by reference.

[0002] Ascorbic acid and its various derivatives are known as compounds exhibiting beneficial effects such as skin whitening, antioxidant activity, and collagen synthesis promotion, and are incorporated into pharmaceuticals, cosmetics, animal feed, etc. In particular, among ascorbic acid derivatives, compounds in which the hydroxyl group at the 2-position is phosphorylated and the hydroxyl group at the 6-position is esterified with palmitic acid (hereinafter also referred to as "ascorbyl palmitate phosphate") and their salts are resistant to oxidation, stable, and amphiphilic. Therefore, ascorbyl palmitate phosphate has high affinity for living organisms and is rapidly transferred to biological tissues such as the skin. For this reason, ascorbyl palmitate phosphate is expected to be applied to pharmaceuticals, cosmetics, animal feed, etc.

[0003] However, it has been found that when a salt of ascorbyl palmitate phosphate is dissolved in water and formulated, hydrolysis occurs over time in the formulation, resulting in turbidity and precipitation. To address this issue, Patent Document 1 proposes coexisting a salt of ascorbyl palmitate phosphate with a dihydric alcohol having 5 or 6 carbon atoms, with the amount of the dihydric alcohol being 0.05% by mass or more but less than 12% by mass. It has been reported that this inhibits decomposition of the salt of a higher fatty acid ester of ascorbic acid 2-phosphate, thereby preventing turbidity and precipitation over time.

[0004] Japanese Patent Application Laid-Open No. 2005-336156

[0005] Patent Document 1 describes that a stabilizing effect is achieved by mixing a salt of ascorbyl palmitate phosphate with purified water, other ingredients, and a dihydric alcohol having 5 or 6 carbon atoms. When producing topical skin preparations and the like, in order to maximize the stabilizing effect of the salt of ascorbyl palmitate phosphate, it has been preferable to mix a powder of the salt of ascorbyl palmitate phosphate that has been frozen and stored with the dihydric alcohol having 5 or 6 carbon atoms immediately before producing the topical skin preparation and the like.

[0006] When producing topical skin preparations and the like, a simpler and more efficient method for preparing topical skin preparations and the like is desired. For example, when producing topical skin preparations and the like, it may be necessary to precisely add a small amount of frozen ascorbyl palmitate phosphate salt powder to the topical skin preparation and the like. When precisely adding a small amount of ascorbyl palmitate phosphate salt to the topical skin preparation and the like, a method for more easily handling the ascorbyl palmitate phosphate salt is desired.

[0007] Therefore, an object of the present disclosure is to provide a liquid composition containing a salt of ascorbyl palmitate phosphate, which enables stable storage of a salt of ascorbyl palmitate phosphate in a liquid state, and a method for storing a salt of ascorbyl palmitate phosphate.

[0008] Generally, when precise addition of small amounts is required, it is easier to handle a solution than a powder. Although aqueous solutions of ascorbyl palmitate phosphate salts can be easily prepared, it has been thought that dissolving them in organic solvents is difficult. The present inventors focused on dihydric alcohols capable of dissolving ascorbyl palmitate phosphate salts and found that when a composition containing the dihydric alcohol and an ascorbyl palmitate phosphate salt is prepared, the stability of the ascorbyl palmitate phosphate salt is high.

[0009] The present disclosure includes the following aspects. [1] A liquid composition containing a dihydric alcohol and a salt of ascorbyl palmitate phosphate, wherein the content of the dihydric alcohol is greater than 90.00% by mass. [2] The liquid composition according to [1], wherein the dihydric alcohol is a dihydric alcohol having a primary hydroxyl group at position 1 and a secondary hydroxyl group at position 2. [3] The liquid composition according to [1], wherein the dihydric alcohol is one or more compounds selected from dihydric alcohols represented by the following general formula (1) or the following general formula (2): R １ -CH(OH)-CH ２ (OH) (1) (In formula (1), R １ is an organic group having 3 to 8 carbon atoms and not having an alcoholic hydroxyl group) ２ -O-CH ２ -CH(OH)-CH ２ (OH) (2) (In formula (2), R ２ is an organic group having 6 to 8 carbon atoms and not having an alcoholic hydroxyl group.) [4] The liquid composition according to any one of [1] to [3], wherein the salt of ascorbyl palmitate phosphate is a sodium salt. [5] The liquid composition according to any one of [1] to [4], wherein the content of the salt of ascorbyl palmitate phosphate is 0.05 to 1.50 mass%. [6] The liquid composition according to any one of [1] to [4], wherein the dihydric alcohol is one or more compounds selected from the group consisting of 3-(hexyloxy)-1,2-propanediol, 3-(cyclohexyloxy)-1,2-propanediol, 1,2-hexanediol, 1,2-pentanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol. [7] A method for preserving a salt of ascorbyl palmitate phosphate, comprising the steps of: preparing a liquid composition containing the salt of ascorbyl palmitate phosphate according to any one of [1] to [4]; and preserving the liquid composition containing the salt of ascorbyl palmitate phosphate.

[0010] According to the present disclosure, there are provided a liquid composition containing a salt of ascorbyl palmitate phosphate, which allows the salt of ascorbyl palmitate phosphate to be stably stored in a liquid state, and a method for storing the salt of ascorbyl palmitate phosphate. According to the present disclosure, when preparing topical skin preparations and the like, the salt of ascorbyl palmitate phosphate can be handled in a liquid state, thereby simplifying the operations involved in producing the topical skin preparations and the like.

[0011] Hereinafter, embodiments of the present invention will be described in detail, but the present invention is not limited to the embodiments described below.

[0012] A numerical range expressed using "to" means a range that includes the numerical values ​​before and after "to" as the lower and upper limits.

[0013] (Liquid composition containing a salt of ascorbyl palmitate phosphate) A first aspect of the present disclosure is a liquid composition containing a salt of ascorbyl palmitate phosphate. In one embodiment, the liquid composition containing a salt of ascorbyl palmitate phosphate is a liquid composition containing a dihydric alcohol and a salt of ascorbyl palmitate phosphate. In one embodiment, the content of the dihydric alcohol in the liquid composition is greater than 90% by mass.

[0014] In one embodiment, the liquid composition contains a dihydric alcohol and a salt of ascorbyl palmitate phosphate, and the content of the dihydric alcohol is greater than 90% by mass.

[0015] <Salt of ascorbyl palmitate phosphate> Salt of ascorbyl palmitate phosphate is a compound that has been imparted lipophilicity by adding palmitic acid to ascorbyl phosphate, a hydrophilic vitamin C derivative, and is an amphiphilic vitamin C derivative that combines hydrophilicity and lipophilicity.

[0016] Ascorbyl palmitate phosphate is a compound in which the hydroxyl group at the 2-position of ascorbic acid is phosphorylated and the hydroxyl group at the 6-position is esterified with palmitic acid. Ascorbyl palmitate phosphate is represented by the following chemical formula (A):

[0017]

[0018] The salt of ascorbyl palmitate phosphate is a compound in which ascorbyl palmitate phosphate forms a salt with a base. Examples of the salt of ascorbyl palmitate phosphate include alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt and magnesium salt; and other metal salts such as zinc salt and iron salt. The salt of ascorbic palmitate phosphate is preferably an alkali metal salt, and more preferably a sodium salt. In one embodiment, the salt of ascorbyl palmitate phosphate is a sodium salt.

[0019] Examples of salts of ascorbyl palmitate phosphate include compounds represented by the following chemical formula (B).

[0020]

[0021] The compound represented by the chemical formula (B) is called ascorbyl palmitate phosphate trisodium (hereinafter also referred to as "APPS") and is sold under the trade name APPLECIER (registered trademark) by Resonac Co., Ltd. APPS is a suitable example of a salt of ascorbyl palmitate phosphate.

[0022] The content of the ascorbyl palmitate phosphate salt in the liquid composition of this embodiment may be, for example, 0.01% by mass or more, 0.02% by mass or more, 0.03% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, relative to the total mass (100% by mass) of the liquid composition. The content of the ascorbyl palmitate phosphate salt may be, for example, 10.00% by mass or less, 5.00% by mass or less, 3.00% by mass or less, 1.50% by mass or less, or 1.00% by mass or less, relative to the total mass (100% by mass) of the liquid composition. The upper and lower limits exemplified above may be any combination. The content of the ascorbyl palmitate phosphate salt may be, for example, 0.01 to 10.00% by mass, preferably 0.02 to 5% by mass, more preferably 0.03 to 3.00% by mass, even more preferably 0.05 to 1.50% by mass, and even more preferably 0.10 to 1.00% by mass, relative to the total mass (100% by mass) of the liquid composition. In one embodiment, the liquid composition contains the ascorbyl palmitate phosphate salt in an amount of 0.05 to 1.50% by mass.

[0023] <Dihydric Alcohol> The dihydric alcohol is a compound having two hydroxyl groups. In one embodiment, the dihydric alcohol is a dihydric alcohol having a primary hydroxyl group and a secondary hydroxyl group. As the dihydric alcohol having a primary hydroxyl group and a secondary hydroxyl group, for example, a dihydric alcohol having hydroxyl groups at the 1st and 2nd positions is preferable. The number of carbon atoms in the dihydric alcohol is, for example, 3 to 15 carbon atoms, and preferably 5 to 11 carbon atoms.

[0024] In one embodiment, the dihydric alcohol is one or more compounds selected from dihydric alcohols represented by the following general formula (1) or the following general formula (2).

[0025] R １ -CH(OH)-CH ２ (OH) (1) (In formula (1), R １ is an organic group having 3 to 8 carbon atoms and not having an alcoholic hydroxyl group.

[0026] R ２ -O-CH ２-CH(OH)-CH ２ (OH) (2) (In formula (2), R ２ is an organic group having 6 to 8 carbon atoms and not having an alcoholic hydroxyl group.

[0027] In the formula (1), R １ In the above, examples of the organic group not having an alcoholic hydroxyl group include hydrocarbon groups which may have heteroatoms. The hydrocarbon group may be an aliphatic hydrocarbon group or an aromatic hydrocarbon group, with an aliphatic hydrocarbon group being preferred. The aliphatic hydrocarbon group may be saturated or unsaturated, with a saturated group being preferred. The aliphatic hydrocarbon group may be linear, branched, or may include a ring structure.

[0028] R １ Examples of heteroatoms that the hydrocarbon group may have in the formula (I) include an oxygen atom, a nitrogen atom, a sulfur atom, etc. The heteroatom may be contained in a substituent substituting a hydrogen atom in the hydrocarbon chain, or in a substituent substituting a methylene group in the hydrocarbon chain.

[0029] R １ Preferred examples of include a linear or branched alkyl group having 3 to 8 carbon atoms and a cycloalkyl group having 3 to 8 carbon atoms.

[0030] Specific examples of the compound represented by formula (1) include 1,2-hexanediol, 1,2-pentanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, etc. Among these, 1,2-hexanediol and 1,2-pentanediol are preferred.

[0031] In the formula (2), R ２ In the above, examples of the organic group not having an alcoholic hydroxyl group include hydrocarbon groups which may have heteroatoms. The hydrocarbon group may be an aliphatic hydrocarbon group or an aromatic hydrocarbon group, with an aliphatic hydrocarbon group being preferred. The aliphatic hydrocarbon group may be saturated or unsaturated, with a saturated group being preferred. The aliphatic hydrocarbon group may be linear, branched, or may include a ring structure.

[0032] R ２ In the formula (I), examples of the heteroatom that the hydrocarbon group may have include an oxygen atom, a nitrogen atom, a sulfur atom, etc. The heteroatom may be contained in a substituent substituting a hydrogen atom in the hydrocarbon chain, or in a substituent substituting a methylene group in the hydrocarbon chain.

[0033] R ２ Preferred examples of include a linear or branched alkyl group having 6 to 8 carbon atoms and a cycloalkyl group having 6 to 8 carbon atoms.

[0034] Specific examples of the compound represented by formula (2) include 3-(hexyloxy)-1,2-propanediol (also known as hexylglycerin), 3-(cyclohexyloxy)-1,2-propanediol (also known as cyclohexylglycerin), 3-(2-ethylhexyloxy)-1,2-propanediol (also known as ethylhexylglycerin), 3-(1-methylheptyloxy)-1,2-propanediol (also known as methylheptylglycerin), etc. Among these, hexylglycerin, cyclohexylglycerin, and ethylhexylglycerin are preferred.

[0035] The dihydric alcohol may be used alone or in combination of two or more thereof, and is preferably one or more selected from the group consisting of hexylglycerin, cyclohexylglycerin, 1,2-hexanediol, 1,2-pentanediol, and ethylhexylglycerin.

[0036] In one embodiment, the dihydric alcohol is one or more compounds selected from the group consisting of 3-(hexyloxy)-1,2-propanediol, 3-(cyclohexyloxy)-1,2-propanediol, 1,2-hexanediol, 1,2-pentanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol.

[0037] The content of dihydric alcohol in the liquid composition of this embodiment is higher than 90.00% by mass, relative to the total mass (100% by mass) of the liquid composition. The content of dihydric alcohol in the liquid composition of this embodiment is preferably 95% by mass or more, more preferably 97.00% by mass or more, and even more preferably 99.00% by mass or more, relative to the total mass (100% by mass) of the liquid composition. The content of dihydric alcohol in the liquid composition of this embodiment is 99.99% by mass or less, preferably 99.50% by mass or less, more preferably 99.30% by mass or less, and may even be 99.00% by mass or less, relative to the total mass (100% by mass) of the liquid composition. The upper and lower limits exemplified above may be any combination. The range of the content of the dihydric alcohol in the liquid composition of this embodiment is, for example, greater than 90.00% by mass to 99.99% by mass relative to the total mass (100% by mass) of the liquid composition, preferably 95.00 to 99.50% by mass, and more preferably 97.00 to 99.30% by mass.

[0038] The purity of the dihydric alcohol used in the liquid composition of this embodiment is preferably 95% by mass or more, more preferably 96% by mass or more, more preferably 97% by mass or more, even more preferably 98% by mass or more, and particularly preferably 99% by mass or more.

[0039] The water content of the dihydric alcohol used in the liquid composition of this embodiment is preferably 5% by mass or less, more preferably 4% by mass or less, more preferably 3% by mass or less, even more preferably 2% by mass or less, and particularly preferably 1% by mass or less.

[0040] <Optional Components> In addition to the components described above, the liquid composition of the present embodiment may contain optional components such as water, preservatives, stabilizers, buffers, and pH adjusters.

[0041] <Water> The liquid composition of this embodiment may contain water as an optional component. From the viewpoint of suppressing hydrolysis of the salt of ascorbyl palmitate phosphate, it is preferable that the liquid composition of this embodiment does not contain water. As the water, for example, pure water, ultrapure water, ion-exchanged water, purified water, sterilized purified water, water for injection, etc. can be used. It is preferable to use cosmetic-grade or pharmaceutical-grade water.

[0042] The water content in the liquid composition of this embodiment is 0.00% by mass or more and less than 5.00% by mass, preferably 0.00 to 3.00% by mass, and more preferably 0.00% by mass, relative to the total mass (100% by mass) of the liquid composition.

[0043] The liquid composition of this embodiment is useful as a composition for preserving a salt of ascorbyl palmitate phosphate. It is believed that the salt of ascorbyl palmitate phosphate undergoes hydrolysis of the palmitylate moiety in an aqueous solution. It is believed that such hydrolysis affects the stability of the salt of ascorbyl palmitate phosphate.

[0044] In the liquid composition of this embodiment, the ascorbyl palmitate phosphate salt is dissolved in a high concentration of dihydric alcohol. This prevents hydrolysis of the ascorbyl palmitate phosphate salt, potentially enabling long-term storage (e.g., 12 weeks or more, preferably 24 weeks or more). Since the liquid composition of this embodiment allows the ascorbyl palmitate phosphate salt to be stored in a liquid state, handling during formulation preparation is facilitated. The liquid composition of this embodiment is preferably a solution in which the ascorbyl palmitate phosphate salt is dissolved in a solvent containing a dihydric alcohol.

[0045] (Method for Preserving a Salt of Ascorbyl Palmitate Phosphate) A second aspect of the present invention is a method for preserving a salt of ascorbyl palmitate phosphate. In one embodiment, the method for preserving a salt of ascorbyl palmitate phosphate comprises the steps of preparing a liquid composition containing the salt of ascorbyl palmitate phosphate according to the first aspect (hereinafter also referred to as "step (i)") and preserving the liquid composition containing the salt of ascorbyl palmitate phosphate (hereinafter also referred to as "step (ii)").

[0046] <Step (i)> In step (i), a liquid composition containing the salt of ascorbyl palmitate phosphate according to the first aspect is prepared. The liquid composition can be prepared by mixing the salt of ascorbyl palmitate phosphate, a dihydric alcohol, and optionally other components, and stirring to obtain a uniform solution. The content of the dihydric alcohol in the liquid composition is greater than 90.00% by mass, based on the total mass of the liquid composition.

[0047] The temperature during mixing and stirring is not particularly limited, but may be, for example, 10 to 40°C.

[0048] <Step (ii)> In step (ii), the liquid composition containing the salt of ascorbyl palmitate phosphate prepared in step (i) is stored.

[0049] The liquid composition can be stored in a desired storage container. The storage container is not particularly limited, and for example, a glass container, a resin container, a metal container, or the like can be used. The storage container is preferably a light-shielding airtight container.

[0050] The storage temperature is not particularly limited, but examples thereof include an environment with an ambient temperature of -20 to 40°C. The storage temperature is preferably 0 to 30°C, more preferably 0 to 20°C, and even more preferably 4 to 10°C. The ambient temperature does not need to be constant during the storage period, but is preferably kept approximately constant. The absolute value of the fluctuation range of the ambient temperature is preferably 0 to 5°C, and more preferably 0 to 2°C.

[0051] The storage can be carried out under atmospheric pressure by allowing the storage container containing the liquid composition to stand in an environment where the ambient temperature is controlled within the above range.

[0052] The storage period is not particularly limited. Examples of storage periods include 1 to 3 years. In the method of the present embodiment, the salt of ascorbyl palmitate phosphate can be stably stored in a liquid state for 6 months or more, preferably 1 year or more, and more preferably 3 years or more.

[0053] <Optional Step> After the step (ii), a step of preparing a topical skin preparation may be carried out using a liquid composition containing the salt of ascorbyl palmitate phosphate. The topical skin preparation can be produced by a known production method. For example, the topical skin preparation can be prepared by mixing and stirring the liquid composition with additives commonly used in topical skin preparations (solvents, preservatives, thickeners, emulsifiers, dispersants, pH adjusters, antioxidants, surfactants, oily components, moisturizers, etc.).

[0054] According to the preservation method of this embodiment, by storing a salt of ascorbyl palmitate phosphate in a liquid containing more than 90.00% by mass of a dihydric alcohol, the salt of ascorbyl palmitate phosphate can be stably stored in a liquid state for a long period of time. Furthermore, because the salt is in a liquid state, topical skin preparations and the like can be easily prepared by simply adding a desired amount of solution.

[0055] The present invention will be explained in more detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples.

[0056] (Storage Stability Test) Each of the prepared liquid compositions was left to stand at a temperature of 40° C. for 24 weeks to carry out a storage stability test.

[0057] <Evaluation of APPS Residual Rate> For each composition that had been left standing for 24 weeks, the residual rate (%) of trisodium ascorbyl palmitate phosphate (APPS) was calculated using the following formula: residual rate (%) = 100 × [APPS concentration (%) after standing / APPS concentration (%) immediately after preparation]

[0058] The residual rate of APPS in each liquid composition was evaluated according to the following evaluation criteria. <Evaluation criteria> A: residual rate of 80% or more B: residual rate of 50% or more but less than 80% C: residual rate less than 50%

[0059] The concentration of APPS was measured by high performance liquid chromatography under the following measurement conditions. <High Performance Liquid Chromatography Measurement Conditions> Column: "Shodex (registered trademark) C18P4E" manufactured by Showa Denko K.K. Column temperature: 40°C Eluent: 0.03 M dipotassium hydrogen phosphate / acetonitrile = 40 / 60 Flow rate: 0.7 ml / min Detection: UV 265 nm

[0060] <Evaluation of Precipitation> Each liquid composition that had been left standing for 24 weeks after preparation was visually observed for the formation of precipitation. The results were evaluated according to the following evaluation criteria. <Evaluation criteria> -: No precipitation observed ±: Slight precipitation observed +: Significant precipitation observed

[0061] [Examples 1 to 5, Comparative Example 1] Liquid compositions of Comparative Example 1 and Examples 1 to 5 were prepared by mixing, stirring, and dissolving the components Nos. 1 to 7 according to the blending ratios shown in Table 1. The obtained liquid compositions were allowed to stand at 40°C, and the occurrence of precipitation and the APPS residual rate were examined. The precipitation was evaluated visually according to the above evaluation criteria. The evaluation results after 24 weeks of standing at 40°C are shown in Table 1. Components Nos. 3 to 7 are dihydric alcohols.

[0062]

[0063] [Comparative Examples 2 to 5] Liquid compositions of Comparative Examples 2 to 5 were prepared by mixing, stirring, and dissolving the components No. 1 to 6 according to the blending ratios shown in Table 2. The resulting liquid compositions were allowed to stand at 40°C, and the occurrence of precipitation and the APPS residual rate were examined. The precipitation was evaluated visually according to the above-mentioned evaluation criteria. The evaluation results after 24 weeks of standing at 40°C are shown in Table 2.

[0064] Comparative Examples 6 to 10 Liquid compositions of Comparative Examples 6 to 10 having the blending ratios shown in Table 3 were prepared in the same manner as in Table 1, and the occurrence of precipitation and the APPS residual rate were examined. The evaluation results are shown in Table 3.

[0065]

[0066] The results shown in Table 1 show that the liquid compositions of Examples 1 to 5 had a higher APPS residual rate and suppressed the occurrence of precipitation compared to the liquid composition of Comparative Example 1. These results show that the use of a dihydric alcohol instead of water as a solvent suppresses the decomposition of APPS and improves the stability of the liquid preparation.

[0067] Table 2 examines the case where phenoxyethanol, which has a bactericidal effect, was added. Since the results are the same between Comparative Example 2 in Table 2 and Comparative Example 1 in Table 1, it was predicted that APPS was decomposed due to chemical causes rather than the influence of bacteria or the like. Furthermore, the results shown in Comparative Examples 3 to 5 and Table 3 reveal that when purified water is contained in the liquid composition and the dihydric alcohol is 90% by mass or less, the APPS residual rate is low and, in some cases, precipitation occurs. These results demonstrate that the decomposition of APPS in the liquid composition can be suppressed by increasing the blending ratio of dihydric alcohol to more than 90.00% by mass.

[0068] Although the preferred embodiments of the present invention have been described above, the present invention is not limited to these embodiments. Addition, omission, substitution, and other modifications of the configuration are possible within the scope of the spirit of the present invention. The present invention is not limited by the above description, but is limited only by the scope of the appended claims.

[0069] According to the present disclosure, there are provided a liquid composition containing a salt of ascorbyl palmitate phosphate, which allows the salt of ascorbyl palmitate phosphate to be stably stored in a liquid state, and a method for storing the salt of ascorbyl palmitate phosphate. According to the present disclosure, when preparing topical skin preparations and the like, the salt of ascorbyl palmitate phosphate can be handled in a liquid state, thereby simplifying the operations involved in producing the topical skin preparations and the like.

Claims

1. A liquid composition containing a salt of ascorbyl palmitate phosphate, comprising a dihydric alcohol and a salt of ascorbyl palmitate phosphate, wherein the content of the dihydric alcohol is greater than 90.00% by mass.

2. The liquid composition according to claim 1, wherein the dihydric alcohol is a dihydric alcohol having a primary hydroxyl group at the 1-position and a secondary hydroxyl group at the 2-position.

3. The liquid composition according to claim 1, wherein the dihydric alcohol is one or more compounds selected from dihydric alcohols represented by the following general formula (1) or the following general formula (2): １ -CH(OH)-CH ２ (OH) (1) (In formula (1), R １ is an organic group having 3 to 8 carbon atoms and not having an alcoholic hydroxyl group) ２ -O-CH ２ -CH(OH)-CH ２ (OH) (2) (In formula (2), R ２ is an organic group having 6 to 8 carbon atoms and not having an alcoholic hydroxyl group.

4. The liquid composition according to any one of claims 1 to 3, wherein the salt of ascorbyl palmitate phosphate is a sodium salt.

5. The liquid composition according to any one of claims 1 to 3, wherein the content of the salt of ascorbyl palmitate phosphate is 0.05 to 1.50 mass%.

6. The liquid composition according to claim 1, wherein the dihydric alcohol is one or more compounds selected from the group consisting of 3-(hexyloxy)-1,2-propanediol, 3-(cyclohexyloxy)-1,2-propanediol, 1,2-hexanediol, 1,2-pentanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol.

7. A method for preserving a salt of ascorbyl palmitate phosphate, comprising the steps of: preparing a liquid composition containing the salt of ascorbyl palmitate phosphate according to any one of claims 1 to 3; and preserving the liquid composition containing the salt of ascorbyl palmitate phosphate.

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