Composition for sleep improvement comprising natural extract complex, and use thereof

Abstract

The present invention relates to a composition for preventing or treating sleep disorders, the composition comprising a mixture of a Perilla frutescens extract and a Mentha piperita extract as an active ingredient. Specifically, the mixture, which is the active ingredient of the present invention, of a Perilla frutescens extract and a Mentha piperita extract improves sleep quality by reducing sleep latency and prolonging sleep duration in animal models, and thus can be effectively used as a composition for effectively improving sleep in which the composition is a natural substance with few side effects.

Description

Composition for improving sleep comprising natural extract complex and use thereof

[0001] The present invention relates to a composition for preventing or treating sleep disorders, comprising a mixture of Perilla frutescens and peppermint (Mentha piperita) as an active ingredient.

[0002] This invention was supported by the Gyeonggi Regional Cooperation Research Center, Gyeonggi Regional Cooperation Research Center (GRRC) Project: Research Center for Technology to Address Unsolved Diseases of the Aging Society (Project Identification Number: GRRCAjou2023-B01) (Research Period: July 1, 2023 - June 30, 2029, Implementing Organization: Ajou University Industry-Academic Cooperation Foundation).

[0003] Sleep disorders are a common problem faced by modern people. Sleep disorders can be defined as a lack of healthy sleep, difficulty maintaining daytime alertness despite adequate sleep, or a disruption in sleep rhythms that causes difficulty falling asleep or staying awake. Chronic sleep deprivation can increase the risk of developing high blood pressure, diabetes, dementia, and obesity. Furthermore, it weakens the immune system, making people more susceptible to infectious diseases like the common cold. It can also increase the risk of memory impairment, stroke, accelerated skin aging, increased risk of heart disease, and bone loss.

[0004] According to statistics from the National Health Insurance Service, 1,098,819 patients received hospital treatment for sleep disorders in 2022. This represents a whopping 30% increase over the four-year period from 855,025 in 2018. With the number of people suffering from sleep disorders exceeding one million, the number of patients is increasing every year.

[0005] To treat these sleep disorders, chemical hypnotics are used, which reversibly suppress the central nervous system to induce and maintain sleep. Conventional hypnotics have central depressant effects similar to anesthetics, producing sedation in small doses and sleep in moderate doses. However, larger doses can cause coma, paralysis, and respiratory depression. Barbiturates have low safety and can lead to side effects such as tolerance and dependence, as well as serious problems such as memory impairment, delirium, hangovers, dizziness, and headaches.

[0006] Accordingly, the need for natural sleep enhancers that are highly effective and free of drug side effects is increasing, and the desire to improve the quality of sleep not only among insomniacs but also among the general public is increasing, leading to an increase in demand for sleep-enhancing compositions.

[0007] The inventors of the present invention have made great efforts to develop a sleeping drug that is safe in vivo without causing the problems of the above-mentioned side effects, and as a result, they have confirmed that a mixture of natural plants, such as chaga and peppermint, not only increases the duration of sleep but also has the effect of significantly shortening the time it takes to fall asleep, thereby completing the present invention.

[0008] Accordingly, the purpose of the present invention is to provide a pharmaceutical composition, health functional food composition, food additive, cosmetic composition, quasi-drug composition or feed composition for preventing or treating sleep disorders, which comprises a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0009] To achieve the above purpose, the present invention provides a pharmaceutical composition for preventing or treating sleep disorders, comprising a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0010] In addition, the present invention provides a health functional food composition for preventing or improving sleep disorders, which comprises a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0011] In addition, the present invention provides a food additive for preventing or improving sleep disorders, which contains a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0012] In addition, the present invention provides a cosmetic composition for preventing or improving sleep disorders, which comprises a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0013] In addition, the present invention provides a pharmaceutical composition for preventing or improving sleep disorders, which comprises a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0014] In addition, the present invention provides a feed composition for preventing or improving sleep disorders, which comprises a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0015] A mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract according to one embodiment of the present invention showed the efficacy of reducing the time it takes to fall asleep and increasing the sleep time in an animal model, and therefore can be usefully used as a composition for improving sleep that is effective and has few side effects as a natural product.

[0016] FIG. 1 is a diagram showing the results of measuring the effect of decreasing the time to fall asleep (latency) and increasing the total sleep time (duration) according to the concentration of a group administered with a complex of chazzi and peppermint extract (PF+MP) in a pentobarbital-induced sleep model according to one embodiment of the present invention.

[0017] FIG. 2 is a diagram showing the results of measuring the effect of decreasing the time to fall asleep (latency) and increasing the total sleep time (duration) of the administration group of the chazzi + peppermint extract complex (PF + MP) compared to the administration groups of the chazzi hot water extract (PF) and the peppermint hot water extract (MP) at a dose concentration of 5 mg / kg according to one embodiment of the present invention.

[0018] FIG. 3 is a diagram showing the results of measuring the effect of decreasing the time to fall asleep (latency) and increasing the total sleep time (duration) of the administration group of the chazzi + peppermint extract complex (PF + MP) compared to the administration groups of the chazzi hot water extract (PF) and the peppermint hot water extract (MP) at a dose concentration of 10 mg / kg according to one embodiment of the present invention.

[0019] FIG. 4 is a diagram showing the results of measuring the effect of decreasing the time to fall asleep (latency) and increasing the total sleep time (duration) of the administration group of the chazzi + peppermint extract complex (PF + MP) compared to the administration groups of the chazzi hot water extract (PF) and the peppermint hot water extract (MP) at a dose concentration of 20 mg / kg according to one embodiment of the present invention.

[0020] FIG. 5 is a diagram showing the results of measuring the effect of decreasing the time to fall asleep (latency) and increasing the total sleep time (duration) of a group administered a complex of chazzi and peppermint extracts (PF+MP) with different compound ratios compared to each of the groups administered a hot water extract of chazzi (PF) and a hot water extract of peppermint (MP) at a dose concentration of 5 mg / kg according to one embodiment of the present invention.

[0021] FIG. 6 is a diagram showing the results of measuring the effect of decreasing the time to fall asleep (latency) and increasing the total sleep time (duration) of a group administered a complex of chazzi and peppermint extracts (PF+MP) with different compound ratios compared to each of the groups administered a hot water extract of chazzi (PF) and a hot water extract of peppermint (MP) at a dose concentration of 10 mg / kg according to one embodiment of the present invention.

[0022] Hereinafter, the present invention will be described in detail.

[0023] The present inventors have diligently sought to develop a natural composition for preventing, improving, or treating sleep disorders with minimal side effects. As a result, they discovered that a mixture of chaga extract and peppermint extract significantly reduced the time it took to fall asleep and increased sleep duration in animal models.

[0024] Accordingly, the present invention provides a pharmaceutical composition for preventing or treating sleep disorders, comprising a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0025] In one embodiment of the present invention, the extraction solvent may be water, alcohol, or a mixture thereof. The alcohol may be a lower alcohol having a C1 to C4 content, and the lower alcohol may include 30% ethanol, 50% ethanol, 70% ethanol, or methanol. Preferably, the extract may be hot water extracted at a temperature of 70 to 90°C, and more specifically, the extraction may be performed at a temperature of 75 to 90°C, 75 to 80°C, 70 to 85°C, or 70 to 80°C, 80 to 90°C, and most preferably, 75 to 85°C, but is not limited thereto.

[0026] In addition, the tea extract and peppermint extract of the present invention include any one of an extract obtained by extraction treatment of tea or peppermint, a diluted or concentrated extract, a dried product obtained by drying the extract, or a controlled or purified product thereof.

[0027] In one embodiment of the present invention, the extract mixture may be a mixture of a citronella plant extract and a peppermint extract in a weight ratio of 1:0.1 to 10. The citronella plant and the peppermint may be mixed in their respective weight ratios and simultaneously extracted using the above-described extraction method, or the citronella plant extract and the peppermint extract obtained by extraction using the above-described extraction method may be mixed in the respective weight ratios to obtain the mixture. Within the above-described mixing ratio, the sleep disorder improvement effect may be superior to that of the individual extracts.

[0028] In one embodiment of the present invention, the tea tree extract and the peppermint extract may be mixed in the following weight ratios. They may be mixed in the following weight ratios: 1: 0.1 to 10, 1: 0.1 to 8, 1: 0.3 to 8, 1: 0.3 to 5, 1: 0.5 to 3, and preferably in the following weight ratios: 1: 0.1 to 3, 1: 0.1 to 1.5, 1: 0.1 to 2. Most preferably, they may be mixed in the following weight ratio: 1: 0.1 to 1, but are not limited thereto.

[0029] The term 'prevention' in the present invention refers to any action that suppresses or delays the onset of a disease or symptom related to sleep disorder by using the tea extract and peppermint extract of the present invention.

[0030] In one embodiment of the present invention, the prevention, improvement, or treatment of the sleep disorder may involve increasing the effect of reducing the time it takes to fall asleep or increasing the duration of sleep. When a mixture of chaga extract and peppermint extract was administered to a mouse model, it was confirmed that the time it takes to fall asleep decreases and the sleep duration increases.

[0031] In one embodiment of the present invention, the sleep disorder may be at least one selected from the group consisting of sleep onset disorder, sleep maintenance disorder, mid-sleep awakening, early awakening, deep sleep disorder, insomnia, nightmares, sleepwalking, narcolepsy, abnormal behavior during sleep, hypersomnia, sleep attacks, breathing-related sleep disorders, apnea, circadian rhythm sleep disorders, parasomnia, restless legs syndrome, and periodic limb movement disorder.

[0032] The pharmaceutical composition of the present invention comprises, in addition to the active ingredient, a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier contained in the pharmaceutical composition of the present invention is one commonly used in formulation, and includes, but is not limited to, lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia gum, calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methyl cellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, and mineral oil. In addition to the above components, the pharmaceutical composition of the present invention may further comprise a lubricant, a wetting agent, a sweetening agent, a flavoring agent, an emulsifier, a suspending agent, a preservative, and the like. Suitable pharmaceutically acceptable carriers and formulations are described in detail in Remington's Pharmaceutical Sciences (19th ed., 1995).

[0033] The appropriate dosage of the pharmaceutical composition of the present invention may be prescribed in various ways depending on factors such as the formulation method, administration method, patient age, weight, sex, pathological condition, food, administration time, administration route, excretion rate, and response sensitivity. Meanwhile, the dosage of the pharmaceutical composition of the present invention may be 0.001-1000 mg / kg per day in one embodiment, and may be administered once a day or divided into several doses. A single dose is 1 to 100 mg / kg, 1 to 80 mg / kg, 1 to 60 mg / kg, 1 to 40 mg / kg, 1 to 30 mg / kg, 5 to 100 mg / kg, 5 to 80 mg / kg, 5 to 60 mg / kg, 5 to 40 mg / kg, 5 to 30 mg / kg, 5 to 25 mg / kg, 5 to 10 mg / kg, 10 to 100 mg / kg, 10 to 80 mg / kg, 10 to 60 mg / kg, 10 to 40 mg / kg, 10 to 30 mg / kg, 15 to 100 mg / kg, 15 to 80 mg / kg, 15 to 60 mg / kg, 15 to 40 mg / kg, 15 to 30 mg / kg, 20 to It may be 100 mg / kg, 20 to 80 mg / kg, 20 to 60 mg / kg, 20 to 40 mg / kg, 20 to 30 mg / kg, and preferably 1 to 50 mg / kg per dose, but is not limited thereto.

[0034] A method for preventing or treating sleep disorders is provided, comprising a step of administering to a subject a pharmaceutical composition of the present invention in a pharmaceutically effective amount.

[0035] The composition may be administered via any conventional route as long as it can reach the target tissue. The composition of the present invention may be administered intraperitoneally, intravenously, intramuscularly, subcutaneously, intradermally, orally, intranasally, intrapulmonary, or rectally, depending on the intended purpose, but is not limited thereto. Furthermore, the composition may be administered via any device capable of transporting the active ingredient to target cells.

[0036]

[0037] In addition, as another aspect of the present invention, the present invention provides a health functional food composition for preventing or improving sleep disorders, which comprises a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0038] The term "improvement" as used in the present invention means any action that at least reduces a parameter related to the condition being treated, for example, the severity of a symptom.

[0039] The health functional food composition according to the present invention can be formulated in the same manner as the pharmaceutical composition and used as a functional food or added to various foods. Foods to which the composition of the present invention can be added include, for example, beverages, alcoholic beverages, confectionery, diet bars, dairy products, meat, chocolate, pizza, ramen, other noodles, gum, ice cream, vitamin complexes, health supplements, and the like.

[0040] The health functional food composition of the present invention may include not only a mixture of citronella and peppermint as active ingredients, but also ingredients commonly added during food manufacturing, such as proteins, carbohydrates, fats, nutrients, seasonings, and flavoring agents. Examples of the carbohydrates described above include monosaccharides such as glucose, fructose, etc.; disaccharides such as maltose, sucrose, oligosaccharides, etc.; and polysaccharides such as dextrin, cyclodextrin, etc., and sugar alcohols such as xylitol, sorbitol, and erythritol. Natural flavoring agents [thaumatin, stevia extracts (e.g., rebaudioside A, glycyrrhizin, etc.]) and synthetic flavoring agents (saccharin, aspartame, etc.) can be used. For example, when the food composition of the present invention is manufactured into a drink or beverage, citric acid, liquid fructose, sugar, glucose, acetic acid, malic acid, fruit juice, and various plant extracts may be additionally included in addition to the tea and peppermint mixture of the present invention.

[0041]

[0042] In addition, the present invention provides a food additive for preventing or improving sleep disorders, which contains a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0043] In the present invention, the term "food additive" means a component that can be added as an auxiliary to food, and can be appropriately selected and used by those skilled in the art as added in the production of food of each formulation. Examples of food additives include various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic flavoring agents and natural flavoring agents, coloring agents and fillers, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloid thickeners, pH regulators, stabilizers, preservatives, glycerin, alcohol, carbonating agents used in carbonated beverages, etc., but the types of food additives of the present invention are not limited by the above examples.

[0044]

[0045] In addition, the present invention provides a pharmaceutical composition for preventing or improving sleep disorders, which comprises a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0046] The quasi-drug composition of the present invention refers to products that have a milder effect than a pharmaceutical product among products used for the purpose of diagnosing, treating, improving, alleviating, managing or preventing diseases of humans or animals. For example, according to the Pharmaceutical Affairs Act, quasi-drugs are products excluding products used for the purpose of pharmaceutical products, and include products used for treating or preventing diseases of humans or animals, products that have a mild effect on the human body or do not act directly, etc.

[0047] In one embodiment of the present invention, when used as an over-the-counter drug composition, the composition may be added as is or used in combination with other over-the-counter drug ingredients, and may be used appropriately according to conventional methods. The amount of active ingredients mixed may be appropriately determined depending on the intended use (prevention, health, or therapeutic treatment).

[0048]

[0049] In addition, the present invention provides a cosmetic composition for preventing or improving sleep disorders, which comprises a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0050] The cosmetic composition of the present invention contains a chazzi extract and a peppermint extract as active ingredients and can be manufactured in the form of a basic cosmetic composition (toner, skin protectant, cream, essence, cleansing foam and cleansing water-like cleanser, pack, body oil, full-body cleanser), a color cosmetic composition (foundation, lipstick, mascara, makeup base), a hair product composition (shampoo, rinse, scalp cleanser, hair conditioner, hair gel), and a soap, etc., together with a dermatologically acceptable excipient.

[0051]

[0052] In addition, the present invention provides a feed composition for preventing or improving sleep disorders, which comprises a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as an active ingredient.

[0053] Sleep plays a crucial role in the health of not only humans but also pets. Chronic sleep disturbances in pets can lead to increased stress hormones and weaken the immune system, increasing the risk of infection. To address this, the feed composition of the present invention, containing a mixture of chamomile and peppermint as active ingredients, for preventing or improving sleep disorders can be used to improve the quality of sleep in animals.

[0054] Since the feed composition of the present invention utilizes effective ingredients extracted from nature, unlike chemically synthesized substances, side effects can be minimized when consumed by animals such as livestock.

[0055] The feed composition for preventing or improving sleep disorders of the present invention may be a substance added to feed or constituting feed to improve or alleviate sleep disorders in companion animals, livestock animals, and wild animals, and may include companion animals such as dogs, cats, and rabbits, livestock such as chickens, cows, pigs, and ducks, wild animals such as tigers, giraffes, deer, and eagles, and all animals such as fish and shellfish.

[0056] The above feed composition may be added during the manufacture of animal feed, or may be used as an additive to finished animal feed. Furthermore, the form of the feed composition is not limited to powder, and may be a formulation suitable for use as a feed additive.

[0057] In one embodiment, a single dose is 1 to 100 mg / kg, 1 to 80 mg / kg, 1 to 60 mg / kg, 1 to 40 mg / kg, 1 to 30 mg / kg, 5 to 100 mg / kg, 5 to 80 mg / kg, 5 to 60 mg / kg, 5 to 40 mg / kg, 5 to 30 mg / kg, 5 to 25 mg / kg, 5 to 10 mg / kg, 10 to 100 mg / kg, 10 to 80 mg / kg, 10 to 60 mg / kg, 10 to 40 mg / kg, 10 to 30 mg / kg, 15 to 100 mg / kg, 15 to 80 mg / kg, 15 to 60 mg / kg, 15 to 40 mg / kg, 15 to 30 mg / kg, It may be 20 to 100 mg / kg, 20 to 80 mg / kg, 20 to 60 mg / kg, 20 to 40 mg / kg, 20 to 30 mg / kg, and preferably 1 to 50 mg / kg per dose, but is not limited thereto.

[0058] When the above composition is taken in amounts below the above range, the effect of improving sleep disorders may not be observed, and when taken in amounts exceeding the above range, the effectiveness may be reduced.

[0059] Duplicate contents are omitted in consideration of the complexity of this specification, and terms not otherwise defined in this specification have meanings commonly used in the technical field to which the present invention belongs.

[0060]

[0061] To facilitate understanding of the present invention, preferred examples are presented below. However, the following examples are provided solely to facilitate understanding of the present invention, and the scope of the present invention is not limited by the examples.

[0062]

[0063] Example 1. Preparation of tea tree and peppermint extracts

[0064] Perilla frutescens var. acuta kudo) and peppermint (Mentha piperita) were extracted with hot water at 80°C and then sterilized at 121°C for 20 minutes to prepare hot water extracts of Perilla frutescens and peppermint. The obtained extracts were filtered and concentrated under reduced pressure, and then powdered by freeze-drying for use.

[0065]

[0066] Example 2. Establishment of a pentobarbital-induced sleep model

[0067] To confirm the sleep disorder-improving effect of the natural extract complex according to the present invention, ICR mice were purchased from Orient Bio Co., Ltd. The mice were then divided into five groups: a group administered with a PF (Perilla frutescens) hot water extract, a group administered with a MP (Peppermint) hot water extract, a group administered with a PF+MP (Perilla frutescens + Peppermint extract complex), a control group, and a group administered with DZP (diazepam). Each substance was administered orally once. The control group mice were administered saline.

[0068] Thirty minutes after administering the test substance, mice were intraperitoneally administered 45 mg / kg of pentobarbital, a tranquilizer purchased from Hanlim Pharmaceutical Co., Ltd., to induce sleep. Latency time and total sleep duration were then measured. Shorter latency times and longer durations indicate greater sleep-enhancing efficacy.

[0069]

[0070] Example 3. Confirmation of the efficacy of reducing latency and increasing total sleep time (duration) by concentration of natural extract complex.

[0071] In order to confirm the sleep disorder improvement effect according to the concentration of the natural extract complex according to the present invention, the sleep onset time (latency) and total sleep time (duration) were measured by varying the concentration of the PF+MP (peppermint extract complex) administration group in the pentobarbital-induced sleep model constructed as in Example 2, and the results are shown in Fig. 2.

[0072] As shown in Fig. 2, compared to the control group administered saline, the time to fall asleep was significantly reduced in all groups administered the tea tree + peppermint extract complex, and the total sleep time was significantly increased.

[0073]

[0074] Example 4. Synergistic effect of natural extract complex on reducing latency and increasing total sleep time compared to single extract.

[0075] In order to confirm the synergistic effect of the natural extract complex compared to the single extract, the concentrations of each administration group were set to 5 mg / kg, 10 mg / kg, and 20 mg / kg, and then the sleep onset time (latency) and total sleep time (duration) of the administration group of the PF+MP complex were evaluated compared to the PF and MP administration groups, respectively. The results are shown in Figures 3 to 5.

[0076] As shown in Figures 3 to 5, when the tea tree + peppermint extract complex was administered, the time to fall asleep was significantly reduced compared to when a single extract was administered, and the total sleep time was significantly increased, confirming the synergistic effect of the tea tree + peppermint extract complex on improving sleep.

[0077]

[0078] Example 5. Synergistic effects of natural extract compounds on reducing latency and increasing total sleep time (duration) by compound ratio.

[0079] In order to confirm the synergistic effect according to the compound ratio of the natural extract complex, the concentrations of each administration group were set to 5 mg / kg and 10 mg / kg, and then compared with the administration groups of the chazzi hot water extract (PF) and peppermint hot water extract (MP), respectively, to evaluate the sleep onset time (latency) and total sleep time (duration) of the chazzi + peppermint extract complex (PF + MP) administration group with different compound ratios, and the results are shown in Figures 6 and 7.

[0080] As shown in Figures 6 and 7, even when various ratios of the tea tree + peppermint extract complex were administered, the time to fall asleep was significantly reduced compared to when a single extract was administered, and the total sleep time was significantly increased, confirming that the tea tree + peppermint extract complex showed a synergistic effect even when the ratios of the complex were different.

[0081]

[0082] In summary, administration of the present invention's tea tree and peppermint extract complex resulted in a decrease in falling asleep time and an increase in sleep time compared to the single extract administration group, specifically confirming that the tea tree and peppermint extract mixture exhibits a sleep-improving effect. These results confirmed that the present invention's tea tree and peppermint extract complex has a sleep-improving effect.

[0083] A mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract according to one embodiment of the present invention showed the efficacy of reducing the time it takes to fall asleep and increasing the sleep time in an animal model, and therefore, as a natural product, it can be usefully used as a composition for improving sleep with few side effects and is effective, and thus has industrial applicability.

Claims

1. A pharmaceutical composition for preventing or treating sleep disorders, comprising a mixture of an extract of Perilla frutescens and an extract of peppermint (Mentha piperita) as an active ingredient.

2. In paragraph 1, A pharmaceutical composition for preventing or treating sleep disorders, wherein the extract is extracted using water, alcohol or a mixture thereof as a solvent.

3. In paragraph 1, A pharmaceutical composition for preventing or treating sleep disorders, wherein the above extract is obtained by hot water extraction at a temperature of 70 to 90°C.

4. In paragraph 1, A pharmaceutical composition for preventing or treating sleep disorders, wherein the mixture comprises a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract in a weight ratio of 1:0.1 to 1.

5. In paragraph 1, The above composition is a pharmaceutical composition for preventing or treating sleep disorders, which reduces the time it takes to fall asleep or increases the duration of sleep.

6. In paragraph 1, A pharmaceutical composition for preventing or treating sleep disorders, wherein the sleep disorder is at least one selected from the group consisting of sleep onset disorder, sleep maintenance disorder, mid-sleep awakening, early awakening, deep sleep disorder, insomnia, nightmares, sleepwalking, narcolepsy, abnormal behavior during sleep, hypersomnia, sleep attacks, breathing-related sleep disorders, apnea, circadian rhythm sleep disorders, parasomnia, restless leg syndrome, and periodic limb movement disorder.

7. A health functional food composition for preventing or improving sleep disorders, comprising a mixture of an extract of Perilla frutescens and an extract of peppermint (Mentha piperita) as active ingredients.

8. A food additive for preventing or improving sleep disorders, comprising a mixture of Perilla frutescens extract and peppermint (Mentha piperita) extract as active ingredients.

9. A cosmetic composition for preventing or improving sleep disorders, comprising a mixture of a Perilla frutescens extract and a peppermint (Mentha piperita) extract as active ingredients.

10. A pharmaceutical composition for preventing or improving sleep disorders, comprising a mixture of an extract of Perilla frutescens and an extract of peppermint (Mentha piperita) as active ingredients.

11. A feed composition for preventing or improving sleep disorders, comprising a mixture of a perilla frutescens extract and a peppermint (Mentha piperita) extract as active ingredients.

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