Polymeric nanoparticles, process for producing them and use thereof in nanomedicine
Functionalized poly(isobutene-maleic anhydride) nanoparticles with amino saccharide and N-(4-aminobutyl)guanidine provide selective drug delivery to tumor cells, improving therapeutic efficacy and reducing side effects.
WO2026074515A1 Publication Date: 2026-04-09UNIV DEGLI STUDI DI MILANO BICOCCA +1
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Patent Information
- Application Number
- PCT/IB2025/059981
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-10-04
- Filing Date
- 2025-10-03
- Publication Date
- 2026-04-09
AI Technical Summary
Technical Problem
Existing nanoparticles lack selectivity in transporting and releasing drugs or contrast media exclusively into tumor cells, leading to potential side effects on healthy cells.
Method used
Nanoparticles formed by self-assembly of poly(isobutene-maleic anhydride) functionalized with 1-25% amino saccharide and N-(4-aminobutyl)guanidine, containing active compounds in the internal cavity, allowing selective release into tumor cells.
Benefits of technology
The nanoparticles exhibit selective accumulation in tumor cells, avoiding healthy cells, with pH-dependent surface charge inversion for drug release, enhancing therapeutic efficacy and reducing side effects.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to nanoparticles formed by a hollow polymeric wall, capable of transporting drugs and active substances, or contrast media, across cellular membranes and releasing them at sites of interest. The nanoparticles are formed by self-assembly of poly(isobutene-alt-maleic anhydride) functionalised with an aminosaccharide.
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