Organ-on-a-chip device for mimicking the bone marrow microenvironment, and methods for producing the device moulds, for producing the device, for filling the device, and for using the device
The Organ-on-a-chip device addresses the limitations of previous models by integrating distinct bone marrow niches with a horizontal structure, oxygen gradient, and physiological fluid flow, enhancing the accuracy of in vitro studies and therapeutic applications.
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- FUNDACAO OSWALDO CRUZ (FIOCRUZ)
- Filing Date
- 2025-11-19
- Publication Date
- 2026-05-28
AI Technical Summary
Existing Organ-on-a-chip devices fail to accurately mimic the bone marrow microenvironment, specifically the endosteal, central, and perivascular niches, due to inadequate representation of structural characteristics, oxygen gradients, fluid flow, and shear stresses, leading to discrepancies between in vitro and in vivo cellular behavior.
A device with distinct culture chambers for each niche, featuring a horizontal structure for continuity, oxygen gradient, and physiological fluid flow, simulating the bone marrow's mechanical properties and topography, allowing for cell migration and substance exchange.
The device provides a biomimetic environment that accurately represents bone marrow niches, enabling studies of healthy and pathological conditions, and supports therapeutic protocol development for bone marrow-related diseases.
Smart Images
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