Oral formulation of pimavanserin
Stable oral liquid compositions of Pimavanserin, such as powders and orodispersible tablets, enhance patient compliance and convenience by providing easy administration and extended stability, overcoming the limitations of solid dosage forms for patients with swallowing difficulties.
WO2026139910A1 Publication Date: 2026-07-02LUPIN LTD
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Patent Information
- Application Number
- PCT/IB2025/063428
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-12-24
- Filing Date
- 2025-12-24
- Publication Date
- 2026-07-02
AI Technical Summary
Technical Problem
Current Pimavanserin formulations are limited to solid dosage forms, which are unsuitable for patients with swallowing difficulties, and there is a need for stable liquid compositions that offer improved patient compliance and convenience.
Method used
Development of stable oral liquid compositions, including ready-to-use formulations like powders, granules, and orodispersible tablets, which can be reconstituted to form solutions or suspensions, ensuring ease of administration and stability for extended periods.
Benefits of technology
The new formulations provide improved patient compliance and convenience by allowing flexible dosing regimens and maintaining stability for several months, addressing the challenges of dysphagia and the limitations of solid dosage forms.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to stable oral formulations of pimavanserin or its pharmaceutically acceptable salts, provided in the form of ready-to-use liquids, powders for reconstitution, orally dispersible tablets, and kits containing pre-measured powder and a liquid vehicle for reconstitution. These formulations are stable for longer periods and are palatable, thereby improving patient compliance and adherence in the treatment of psychosis associated with Parkinson's disease.
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