Tetracyclic derivative inhibitor, and preparation method and use therefor

Abstract

The present invention relates to a tetracyclic derivative inhibitor, and a preparation method and use therefor. In particular, the present invention relates to a tetracyclic derivative compound, a preparation method therefor and a pharmaceutical composition containing the compound, and a use thereof in treating cancer.

Description

Technical Field The present invention belongs to the field of drug synthesis and specifically relates to a tetracyclic derivative inhibitor, and a preparation method therefor and the use thereof. Background Art Protein arginine methyltransferases (PRMTs) are classified into three major types based on their catalytic activity and product types: Types I, II, and III. Type I mainly comprises PRMT1 / 2 / 3 / 4 / 6 / 8, which catalyse the formation of asymmetric dimethylarginine (ADMA) on substrates; Type n comprises PRMT5 / 9, which catalyse the formation of symmetric dimethylarginine (SDMA) on substrates; Type III comprises only PRMT7,whichis responsible for catalysing the formation of monomethylarginine (MMA) on substrates. PRMT5 uses S-adenosyl-L-methionine (SAM) as a methyl donor to transfer methyl groups to substrates such as DNA, RNA and histones. Symmetric dimethylation of arginine residues on the substrates generates SDMA, thereby regulating multiple key cellular processes including transcription, translation and DNA repair to maintain cellular homeostasis. In addition, PRMT5 is also involved in regulating the growth and survival pathways of tumour cells and promoting tumourigenesis and progression. Elevated expression of PRMT5 has also been demonstrated to be associated with poor prognosis in a variety of cancers, making it a highly promising epigenetic target. Methylthioadenosine phosphorylase (MTAP) catalyses the conversion of methylthioadenosine (MTA) to methionine, which is essential for maintaining normal cell functions. Deletion mutations in the MTAP gene lead to the accumulation of MTA in cells. MTA competes with PRMT5’s substrate SAM, thereby reducing PRMT5 activity and resulting in abundant formation of PRMT5-MTA complexes. Deletion of the MTAP gene increases tumour dependency on PRMT5, and inhibition of PRMT5 in MTAP-deficient tumours can exert a “synthetic lethal” effect. PARP inhibitors based on the theory of "synthetic lethality" have achieved great success in the field of precision oncology. The MTAP gene is adjacent to CDKN2A, the most common tumour suppressor gene in human cancers, and is often co-deleted with CDKN2A. This co-deletion occurs in 10%-15% of all cancers, mainly in non-small cell lung cancer (12%-20%), glioma (53%), pancreatic cancer (30%), and DLBCL (20%), representing significant market potential. Currently, no PRMT5 inhibitor has been approved for marketing. Early PRMT5 inhibitors were all non-selective, SAM-competitive inhibitors, which exhibited severe haematological toxicity and a narrow therapeutic window in clinical settings. The clinical progress of the first-generation PRMT5 inhibitors GSK-3326595, JNJ-64619178 and PF-06939999 has been suboptimal. The nextgeneration PRMT5 inhibitors targeting the PRMT5-MTA complex are effective specifically against MTAP-deficient, MTA-enriched tumourswhile exhibiting high selectivity for MTAP wild-type tumours. This mechanism reduces haematological toxicity, as has been validated in preclinical studies, and is expected to significantly widen the therapeutic window. The present patent relates to a novel selective PRMT5-MTA inhibitor that exhibits activity specifically against MTAP-deficient cells while showing weak inhibition against MTAP wild-type cells, thereby avoiding the haematological toxicity and other side effectsassociated with the inhibition of MTAP wild-type cells by non-selective PRMT5 inhibitors in clinical settings. Highly selective PRMT5-MTA inhibitors, as novel PRMT5-MTA inhibitors, can be used for the treatment of various tumours, cancers and other diseases. Summary of the Invention The objective of the present invention is to provide a compound represented by general formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein the compound represented by general formula (I) has the following structure: M1 is selected from -N- or -CRa-; M2 is selected from -N- or -CRb-; preferably -CRb-; M3 is selected from N or C; ring A is selected from C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl; preferably C3-6 cycloalkyl, 3- to 6-membered heterocyclyl, phenyl or 5- to 6-membered heteroaryl; ring B is selected from C3-14 cycloalkyl, 3- to 14-membered heterocyclyl, C6-14 aryl or 5- to 14-membered heteroaryl; preferably C3-12 cycloalkyl, 3- to 12membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl; preferably C3-6 cycloalkyl, 3- to 6-membered heterocyclyl, C6-10 fused cycloalkyl, 6- to 10membered fused heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl; L1 is selected from a bond, -(CRaaRbb)m2-, -(CRaaRbb)m2C(O)-,  - (CRaaRbb)m2C(S)-,     -(CRaaRbb)m2C(NRcc)-,     -(CRaaRbb)m2NRccC(O)-,     - (CRaaRbb)m2S(O)m1-,       -(CRaaRbb)m2NRcc-,       -(CRaaRbb)m2P(O)2-,       - (CRaaRbb)m2P(O)(ORcc)-, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably -CRaaRbb-, -C(O)-, -S(O)m1- or NRcc; L2 is selected from a bond, -(CRaaRbb)m2-, -(CRaaRbb)m2C(O)-,  - (CRaaRbb)m2NRccC(O), -(CRaaRbb)m2S(O)m1- or -(CRaaRbb)m2NRcc-; preferably -CRaaRbb-, -C(O)-, -S(O)m1- or NRcc; R1 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, -(CRccRdd)n1-C3-12 cycloalkyl, -(CRccRdd)n1-3- to 12-membered heterocyclyl, -(CRccRdd)n1-C6-12 aryl, -(CRccRdd)n1-5- to 12-membered heteroaryl, -SF5, -ORe, -NReRf, -C(O)Re, -C(O)ORe, - C(O)NReRf, -N=S(O)ReRf, -S(O)Re(=NRf) or -P(O)ReRf, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl and =CRggRhh; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, -(CRccRdd)n1-C3-8 cycloalkyl, -(CRccRdd)n1-3- to 8membered heterocyclyl, -(CRccRdd)n1-C6-10 aryl, -(CRccRdd)n1-5- to 10-membered heteroaryl, -ORe, -NReRf, -C(O)Re, -C(O)NReRf or -P(O)ReRf, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl; alternatively, R1 and Ra, Rb or Rc are connected to form C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably form C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl; R2 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -(CH2)n2ORee, -(CH2)n2NReeRff, -(CH2)n2C(O)Ree, -(CH2)n2C(O)NReeRff, -(CH2)n2P(O)ReeRff or =CReeRff, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyanosubstituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10membered heteroaryl; R3 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -Y1-C3-12 cycloalkyl, -Y1-3- to 12-membered heterocyclyl, -Y1-C6-12 aryl, -Y1-5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh, -C(=NRi)NRgRh or =RgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5- to 12-membered heteroaryl and =CReRf; preferably hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, - C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh or =RgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5- to 12-membered heteroaryl and =CReRf; alternatively, any two R3, together with adjacent atoms to which they are attached, form C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably form C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyanosubstituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl; Ra, Rb, Rc, Re and Rf are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -(CH2)n2ORee, -(CH2)n2NReeRff, -(CH2)n2C(O)Ree, -(CH2)n2C(O)ORee, -(CH2)n2C(O)NReeRff, -(CH2)n2N=S(O)ReeRff, -(CH2)n2S(O)Ree(=NRff) or -(CH2)n2P(O)ReeRff, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl and =CRggRhh; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyanosubstituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl; alternatively, Ra and Rb are connected to form C3-12 cycloalkyl, 3- to 12membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; Y1 is selected from a bond, -O-, -S-, -C(O), -NRj-, -C(O)NRj-, -NRjC(O)-, -S(O)2NRj-, -NRjS(O)2-, C1-6 alkylene, -O-C1-6 alkylene-, -C1-6 alkylene-O-, -NRj-C1-6 alkylene-, -C1-6 alkylene-NRj-, C2-6 alkenylene or C2-6 alkynylene, wherein the C1-6 alkylene, C2-6 alkenylene and C2-6 alkynylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; Rg, Rh, Ri and Rj are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl; Raa, Rbb, Rcc and Rdd are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl; Ree and Rff are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl; Rgg and Rhh are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl; x is selected from 0, 1, 2, 3, 4, 5 or 6; y is selected from 0, 1, 2, 3, 4, 5 or 6; m1 is selected from 0, 1 or 2; m2 is selected from 0, 1 or 2; n1 is selected from 0, 1, 2, 3 or 4; and n2 is selected from 0, 1, 2, 3 or 4. In a preferred embodiment of the present invention, the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof, is characterised in that the      R1      is selected from      R1 ,       R1 ,       R1 ,      R1 or The present invention further provides a compound represented by general formula (A), or a stereoisomer or a pharmaceutically acceptable salt thereof: nn (A) M1 is selected from -N- or -CRa-; Ma is selected from CR2a, NR2a or N; Mb is selected from CR2b, NR2b or N; alternatively, R2a and R2b are connected to form ring A; ring A is selected from C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, which is optionally substituted with 0, 1, 2, 3, 4, 5 or 6 R2c; ring B is selected from C3-14 cycloalkyl, 3- to 14-membered heterocyclyl, C6-14 aryl or 5- to 14-membered heteroaryl; L2 is selected from a bond, -(CRaaRbb)m2-, -(CRaaRbb)m2C(O)-,  - (CRaaRbb)m2NRccC(O), -(CRaaRbb)m2S(O)m1- or -(CRaaRbb)m2NRcc-; L5 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  - (CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, =CR9aR9b, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; L6 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  - (CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, =CR9aR9b, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; L7 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  - (CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, =CR9aR9b, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; R2a is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; R2b is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; R2c is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -(CH2)n2ORee, -(CH2)n2NReeRff, -(CH2)n2C(O)Ree, -(CH2)n2C(O)NReeRff, -(CH2)n2P(O)ReeRff or =CReeRff, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl; R3 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh or =RgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2- 6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5- to 12-membered heteroaryl and =CReRf; R9a and R9b are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; Ra is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -(CH2)n2ORee, -(CH2)n2NReeRff, -(CH2)n2C(O)Ree, -(CH2)n2C(O)NReeRff or -(CH2)n2P(O)ReeRff, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl; Rc is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -(CH2)n2ORee, -(CH2)n2NReeRff, -(CH2)n2C(O)Ree, -(CH2)n2C(O)NReeRff or -(CH2)n2P(O)ReeRff, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl; Re and Rf are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl; Rg and Rh are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl; RN is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl; Raa, Rbb and Rcc are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl; Ree and Rff are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1- 3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl; y is selected from 0, 1, 2, 3, 4, 5 or 6; m1 is selected from 0, 1 or 2; m2 is selected from 0, 1 or 2; n2 is selected from 0, 1, 2, 3 or 4; n8 is selected from 0, 1, 2, 3 or 4; n9 is selected from 0, 1, 2, 3 or 4; n10 is selected from 0, 1, 2, 3 or 4. In a preferred embodiment of the present invention, the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof, is characterised in that the compound is further as represented by general formula (III-E): L5 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  - (CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, C(=CR9aR9b), C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene,  C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably a bond, -O-, -S-, -C(O), -NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; L6 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  - (CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, C(=CR9aR9b), C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably a bond, -O-, -S-, -C(O), -NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; L7 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  - (CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, C(=CR9aR9b), C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene,  C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably a bond, -O-, -S-, -C(O), -NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; ring A, ring B, L2, M1, M3, Rc, R2, R3, x and y are as defined in any one of the above embodiments. In a preferred embodiment of the present invention, the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof, is characterised in that the compound is further as represented by general formula (IV-E): M5 is selected from N or CR3a; M6 is selected from N or CR3b; R5 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl; R3a, R3b, R3d and R3e are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh or -C(=NRi)NRgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5-to 12-membered heteroaryl and =CReRf; R3c is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh or -C(=NRi)NRgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5- to 12-membered heteroaryl and =CReRf; ring A, M1, M3, Rc, R2, x, L5, L6, L7, n8 and n9 are as defined in any one of the above embodiments. In a preferred embodiment of the present invention, ring A is selected from 3- to 12-membered heterocyclyl or 5- to 12-membered heteroaryl; preferably 5- membered heterocyclyl, 6-membered heterocyclyl, 5-membered heteroaryl or 6- membered heteroaryl; more preferably ' ; more preferably In a preferred embodiment of the present invention, ring B is selected from 3- 5 to 6-membered heterocyclyl fused phenyl or 3- to 6-membered heterocyclyl fused 10 In a preferred embodiment of the present invention, ring B is 6- to 14membered tricyclic heterocyclyl; preferably 6- to 14-membered tricyclic spiro heterocyclyl or 6- to 14-membered tricyclic fused heterocyclyl; more preferably 10 In a preferred embodiment of the present invention, the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof, is characterised in that the compound is further as represented by general formula (VI-A) or (VI-B): n11 is selected from 0, 1 or 2; M5 is selected from N or CR3a; M6 is selected from N or CR3b; R3a, R3b, R3d and R3e are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh or -C(=NRi)NRgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5-to 12-membered heteroaryl and =CReRf; R3c is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh or -C(=NRi)NRgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5- to 12-membered heteroaryl and =CReRf. In a preferred embodiment of the present invention, L6 is selected from -O-, -S-, -C(O), -NRN-, C1-3 alkylene or C2-4 alkenylene, wherein the C1-3 alkylene and C2-4 alkenylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; in a preferred embodiment of the present invention, n8 is selected from 1, 2 or 3; n9 is selected from 0, 1 or 2. In a preferred embodiment of the present invention, each R2 or R2c is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, cyanosubstituted C1-3 alkyl, C3-8 cycloalkyl or -C(O)NReeRff, wherein the amino, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, cyano-substituted C1-3 alkyl and C3-8 cycloalkyl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, cyano-substituted C1-3 alkyl and C3-8 cycloalkyl; Ree and Rff are each independently selected from hydrogen, deuterium, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl or cyano-substituted C1-3 alkyl; preferably hydrogen, deuterium, fluorine, chlorine, methyl, deuterated methyl, difluoromethyl, trifluoromethyl, ^ , *      or *      . In a preferred embodiment of the present invention, Ra is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl or cyano-substituted C1-3 alkyl; preferably hydrogen, deuterium, fluorine, chlorine, methyl, deuterated methyl, difluoromethyl or trifluoromethyl. In a preferred embodiment of the present invention, Rc is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl or cyano-substituted C1-3 alkyl; preferably hydrogen, deuterium, fluorine, chlorine, methyl, deuterated methyl, difluoromethyl or trifluoromethyl. In a preferred embodiment of the present invention, the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof, is characterised in that R3 and R3c are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halogenated C1-3 alkoxy, C1-3 hydroxyalkyl, cyanosubstituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl, 5-to 10-membered heteroaryl or -SF5, wherein the amino, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halogenated C1-3 alkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl; R3a, R3b, R3d and R3e are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halogenated C1-3 alkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halogenated C1-3 alkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl. The present invention further provides a compound represented by general formula (A-I), or a stereoisomer or a pharmaceutically acceptable salt thereof: / Pgl Pg2~N / ^Mb n8 ( A-I ) R’ is selected from hydrogen, C1-6 alkyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy or C1-6 hydroxyalkyl; R is selected from halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1- R"  (b7^R3\ R\ s N'L< 6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl or                  ; R’’ is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, -C(O)O-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably a compound represented by general formula (A-II): / Pg' ( A-II) preferably, the compound represented by general formula (A-II) is further as represented by general formula (IV-E-I), general formula (IV-A-I) or general formula (IV-B-I): Pg1 is selected from hydrogen, allyloxycarbonyl, trifluoroacetyl, tert-butylsulphinyl 2,4-dimethoxybenzyl, 3,5-dimethoxybenzyl, nitrobenzenesulphonyl, trityl, fluorenylmethoxycarbonyl, 9-fluorenylmethoxycarbonyl, benzyl, p-toluenesulphonyl, p-methoxybenzyl, formate, acetyl, benzyloxycarbonyl, phthaloyl, tert-butyloxycarbonyl or p-methoxyphenyl; preferably benzyl, p-methoxybenzyl or tert-butyloxycarbonyl; Pg2 is selected from hydrogen, allyloxycarbonyl, trifluoroacetyl, tert-butylsulphinyl 2,4-dimethoxybenzyl, 3,5-dimethoxybenzyl, nitrobenzenesulphonyl, trityl, fluorenylmethoxycarbonyl, 9-fluorenylmethoxycarbonyl, benzyl, p-toluenesulphonyl, p-methoxybenzyl, formate, acetyl, benzyloxycarbonyl, phthaloyl, tert-butyloxycarbonyl or p-methoxyphenyl; preferably hydrogen, benzyl, p-methoxybenzyl or tert-butyloxycarbonyl; M1, Ma, Mb, ring A, ring B, L2, L5, L6, L7, Ra, Rb, Rc, R3, M5, M6, R3a, R3b, R3c, R3d, R3e, R5, n11, n8, n9, x and y are as defined in any one of the above embodiments. The present invention further provides a method for preparing a compound represented by general formula (A), or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein a compound represented by general formula (A-I) is reacted in the presence of a condensing agent and a base to obtain a compound represented by general formula (A-II), which is further deprotected to obtain the compound represented by general 5 formula (A); preferably, the method is a method for preparing a compound represented by general formula (IV-E), or a stereoisomer or a pharmaceutically acceptable salt thereof: (IV-E-II ) 10        a compound represented by general formula (IV-E-I) is reacted in the presence of a condensing agent and a base to obtain a compound represented by general formula (IV-E-II), which is further deprotected to obtain the compound represented by general formula (IV-E); alternatively, the method is a method for preparing a compound represented by 15 general formula (VI-A), or a stereoisomer or a pharmaceutically acceptable salt thereof: a compound represented by general formula (VI-A-I) is reacted in the presence of a condensing agent and a base to obtain a compound represented by general formula (VI-A-II), which is further deprotected to obtain the compound represented by general formula (VI-A); alternatively, the method is a method for preparing a compound represented by general formula (VI-B), or a stereoisomer or a pharmaceutically acceptable salt thereof: a compound represented by general formula (VI-B-I) is reacted in the presence of a condensing agent and a base to obtain a compound represented by general formula (VI-B-II), which is further deprotected to obtain the compound represented by general formula (VI-B); Pg1 is selected from hydrogen, allyloxycarbonyl, trifluoroacetyl, tert-butylsulphinyl 2,4-dimethoxybenzyl, 3,5-dimethoxybenzyl, nitrobenzenesulphonyl, trityl, fluorenylmethoxycarbonyl, 9-fluorenylmethoxycarbonyl, benzyl, p-toluenesulphonyl, p-methoxybenzyl, formate, acetyl, benzyloxycarbonyl, phthaloyl, tert-butyloxycarbonyl or p-methoxyphenyl; preferably benzyl, p-methoxybenzyl or tert-butyloxycarbonyl; Pg2 is selected from hydrogen, allyloxycarbonyl, trifluoroacetyl, tert-butylsulphinyl 2,4-dimethoxybenzyl, 3,5-dimethoxybenzyl, nitrobenzenesulphonyl, trityl, fluorenylmethoxycarbonyl, 9-fluorenylmethoxycarbonyl, benzyl, p-toluenesulphonyl, p-methoxybenzyl, formate, acetyl, benzyloxycarbonyl, phthaloyl, tert-butyloxycarbonyl or p-methoxyphenyl; preferably hydrogen, benzyl, p-methoxybenzyl or tert-butyloxycarbonyl; M1, Ma, Mb, ring A, ring B, L2, L5, L6, L7, Ra, Rb, Rc, R3, M5, M6, R3a, R3b, R3c, R3d, R3e, R5, n11, n8, n9, x and y are as defined in any one of the above embodiments. In a preferred embodiment of the present invention, the condensing agent in the preparation method is selected from thionyl chloride, phosphorus oxychloride, p-toluenesulphonyl chloride, methanesulphonyl chloride, dicyclohexylcarbodiimide, diisopropylcarbodiimide,        1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, carbonyldiimidazole, ethyl chloroformate, 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium         hexafluorophosphate,         O-(benzotriazol-1-yl)- tetramethyluronium hexafluorophosphate or tetramethylchloroformamidinium hexafluorophosphate; preferably phosphorus oxychloride, 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, O-(benzotriazol-1-yl)-tetramethyluronium hexafluorophosphate or tetramethylchloroformamidinium hexafluorophosphate; the base is selected from potassium carbonate, methylamine, triethylamine, diisopropylamine, pyridine, imidazole, N-methylimidazole or N-methylmorpholine. The present invention further relates to a pharmaceutical composition comprising a therapeutically effective dose of the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof as shown in any one of the above embodiments, and one or more pharmaceutically acceptable carriers, diluents, or excipients. The present invention further relates to the use of the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof as shown in any one of the above embodiments, or the pharmaceutical composition in the preparation of a PRMT5 inhibitor drug. The present invention further relates to the use of the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof as shown in any one of the above embodiments, or the pharmaceutical composition thereof in the preparation of a drug for the treatment of a cancer; preferably, the cancer is a cancer with MTAP gene deletion. The present invention further relates to a method of using the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof as shown in any one of the above embodiments, or the pharmaceutical composition thereof in the preparation of a drug for the treatment of a cancer; preferably, the cancer is a cancer with MTAP gene deletion. In some embodiments, the cancer is selected from lung cancer, hepatocellular carcinoma, breast cancer, skin cancer, bladder cancer, liver cancer, pancreatic cancer, head and neck cancer, glioma, glioblastoma, oesophageal cancer, pancreatic cancer, mesothelioma, melanoma, astrocytoma, undifferentiated pleomorphic sarcoma, diffuse large B-cell lymphoma, leukaemia, gastric adenocarcinoma, myxofibrosarcoma, cholangiosarcoma, brain cancer, gastric cancer, renal cancer, endometrial cancer, ovarian tumour, prostate cancer, lymphoma, non-Hodgkin lymphoma, urinary tract cancer, soft tissue cancer, pleural cancer, large intestine cancer, colourectal cancer, biliary tract cancer or cholangiocarcinoma; the lung cancer is selected from non-small cell lung cancer, lung squamous cell carcinoma or lung adenocarcinoma; the oesophageal cancer is selected from oesophageal squamous cell carcinoma or oesophageal adenocarcinoma. The present invention further relates to a method for preventing and / or treating a cancer, wherein the method comprises administering to a patient a therapeutically effective dose of the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof as shown in any one of the above embodiments, or the pharmaceutical composition thereof. The present invention further relates to a method for treating a cancer in a mammal, wherein the method comprises administering to the mammal a therapeutically effective amount of the compound of the present invention, or the pharmaceutically acceptable salt, the ester, the prodrug, the solvate, the hydrate or the derivative thereof. In certain embodiments of the present invention, the weight percent of the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof in the pharmaceutical composition is 0.1%-95%, preferably 90%, 85%, 80%, 75%, 70%, 60%, 50%, based on free base. In certain embodiments of the present invention, the pharmaceutical composition is selected from a tablet, a capsule, a liquid preparation or an injection, preferably further comprises a filler, optionally further comprises a disintegrant, or further comprises one or more of a glidant or a lubricant. In certain embodiments of the present invention, the pharmaceutical composition is an immediate-release preparation or a sustained-release preparation. In certain embodiments of the present invention, the unit dose of the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof in the pharmaceutical composition is 1-1000 mg, preferably 1-500 mg, or preferably 1 mg, 2 mg, 3 mg, 5 mg, 10 mg, 20 mg, 40 mg, 50 mg, 60 mg, 80 mg, 100 mg, 200 mg, 300 mg, 400 mg or 500 mg, based on free base. In certain embodiments of the present invention, the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof can be administered by any convenient method, for example, by oral, parenteral, buccal, sublingual, nasal, rectal, intrathecal or transdermal administration, and the pharmaceutical composition can be adjusted accordingly. In certain embodiments of the present invention, the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof can be formulated into a liquid or solid preparation, such as a syrup, a suspension, an emulsion, a tablet, a capsule, powder, a granule, or a lozenge. In some embodiments, the method relates to the treatment of conditions such as lung cancer, hepatocellular carcinoma, breast cancer, skin cancer, bladder cancer, liver cancer, pancreatic cancer, head and neck cancer, glioma, glioblastoma, oesophageal cancer, pancreatic cancer, mesothelioma, melanoma, astrocytoma, undifferentiated pleomorphic sarcoma, diffuse large B-cell lymphoma, leukaemia, gastric adenocarcinoma, myxofibrosarcoma, cholangiosarcoma, brain cancer, gastric cancer, renal cancer, endometrial cancer, ovarian tumour, prostate cancer, lymphoma, non-Hodgkin lymphoma, urinary tract cancer, soft tissue cancer, pleural cancer, large intestine cancer, colourectal cancer, biliary tract cancer or cholangiocarcinoma. In some embodiments, the lung cancer is selected from non-small cell lung cancer, lung squamous cell carcinoma or lung adenocarcinoma; the oesophageal cancer is selected from oesophageal squamous cell carcinoma or oesophageal adenocarcinoma. Detailed Description of the Invention Unless stated to the contrary, all technical and scientific terms used herein generally have the same meanings as commonly understood by one of ordinary skill in the art. Specifically, the terms used in the description and claims have the following meanings. The term "alkyl" refers to a linear or branched saturated aliphatic hydrocarbon group which may be optionally substituted with one or more substituents. In particular embodiments, the alkyl refers to a linear saturated hydrocarbon group having 1 to 20 (C1-20), 1 to 15 (C1-15), 1 to 12 (C1-12), 1 to 10 (C1-10), 1 to 8 (C1-8), 1 to 6 (C1-6), or 1 to 3 (C1-3) carbon atoms, or a branched saturated hydrocarbon group having 3 to 20 (C3-20), 3 to 15 (C3-15), 3 to 12 (C3-12), 3 to 10 (C3-10), 3 to 8 (C3-8) or 3 to 6 (C3-6) carbon atoms. As used herein, linear C1-6 alkyl and branched C3-6 alkyl groups are also referred to as "lower alkyl". For example, C1-6 alkyl refers to a linear saturated monovalent hydrocarbon group having 1 to 6 carbon atoms or a branched saturated monovalent hydrocarbon group having 3 to 6 carbon atoms. In one embodiment, the C1-6 alkyl contains 1 to 6 (e.g., 1, 2, 3, 4, 5 or 6) carbon atoms. Non-limiting examples include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, sec-butyl, n-pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, 2-methylbutyl, 3-methylbutyl, n-hexyl, 1-ethyl-2-methylpropyl, 1,1,2-trimethylpropyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2-ethylbutyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 2,3-dimethylbutyl, n-heptyl, 2-methylhexyl, 3-methylhexyl, 4-methylhexyl, 5-methylhexyl, 2,3-dimethylpentyl, 2,4-dimethylpentyl, 2,2-dimethylpentyl, 3,3-dimethylpentyl, 2-ethylpentyl, 3-ethylpentyl, n-octyl, 2,3-dimethylhexyl, 2,4-dimethylhexyl, 2,5-dimethylhexyl, 2,2-dimethylhexyl, 3,3-dimethylhexyl, 4,4-dimethylhexyl, 2-ethylhexyl, 3-ethylhexyl, 4-ethylhexyl, 2-methyl-2-ethylpentyl, 2-methyl-3-ethylpentyl, n-nonyl, 2-methyl-2-ethylhexyl, 2-methyl-3-ethylhexyl, 2,2-diethylpentyl, n-decyl, 3,3-diethylhexyl, 2,2-diethylhexyl, various branched isomers thereof, etc. In one embodiment, the alkyl is optionally substituted alkyl as described elsewhere herein. The term "alkylene" refers to alkyl in which one hydrogen atom is further substituted, wherein the "alkyl" is as defined above. Non-limiting examples of "alkylene" include: methylene (-CH2-), ethylene (-(CH2)2-), propylene (-(CH2)3-) or butylene (-(CH2)4-). In one embodiment, the alkylene is optionally substituted alkyl as described elsewhere herein. The term "alkenyl" refers to a linear or branched unsaturated aliphatic hydrocarbon group containing at least one carbon-carbon double bond which may be located at any position within the alkenyl, and the alkenyl may be optionally substituted with one or more substituents. In particular embodiments, the alkenyl is a linear unsaturated hydrocarbon group having 2 to 20 (C2-20), 2 to 15 (C2-15), 2 to 12 (C2-12), 2 to 10 (C2-10), 2 to 8 (C2-8), 2 to 6 (C2-6) or 2 to 4 (C2-4) carbon atoms, or a branched unsaturated hydrocarbon group having 3 to 20 (C3-20), 3 to 15 (C3-15), 3 to 12 (C3-12), 3 to 10 (C3-10), 3 to 8 (C3-8) or 3 to 6 (C3-6) carbon atoms. Unless otherwise specified, the term "alkenyl" as used herein includes both linear and branched alkenyl. For example, C2-6 alkenyl refers to a linear unsaturated hydrocarbon group having 2 to 6 carbon atoms or a branched unsaturated hydrocarbon group having 3 to 6 carbon atoms. In one embodiment, the C2-6 alkenyl contains 2 to 6 (e.g., 2, 3, 4, 5 or 6) carbon atoms. Non-limiting examples of alkenyl include: , / A V^,     o^ . One of ordinary skill in the art can understand that the term "alkenyl" may also include groups having "cis" and "trans" configurations, oralternatively, groups having "E" and "Z" configurations. In one embodiment, the alkenyl is optionally substituted alkenyl as described elsewhere herein. The term "alkenylene" refers to alkenyl in which one hydrogen atom is further substituted, wherein the "alkenyl" is as defined above. In one embodiment, the alkenylene is optionally substituted alkyl as described elsewhere herein. The term "alkynyl" refers to a linear or branched unsaturated aliphatic hydrocarbon group containing at least one carbon-carbon triple bond which may be located at any position within the alkynyl, and the alkynyl may be optionally substituted with one ormore substituents. In particularembodiments, the alkynyl is a linearunsaturated hydrocarbon group having 2 to 20 (C2-20), 2 to 15 (C2-15), 2 to 12 (C2-12), 2 to 10 (C2-10), 2 to 8 (C2-8), 2 to 6 (C2-6), or2 to 4 (C2-4) carbon atoms, or a branched unsaturated hydrocarbon group having 3 to 20 (C3-20), 3 to 15 (C3-15), 3 to 12 (C3-12), 3 to 10 (C3-10), 3 to 8 (C3-8) or3 to 6 (C3-6) carbon atoms. Unless otherwise specified, the term "alkynyl" as used herein includes both linearand branched alkynyl. For example, C2-6 alkynyl refers to a linear unsaturated hydrocarbon group having 2 to 6 carbon atoms or a branched unsaturated hydrocarbon group having 3 to 6 carbon atoms. In one embodiment, the C2-6 alkynyl contains 2 to 6 (e.g., 2, 3, 4, 5 or6) carbon atoms. Non-limiting examples of alkynyl I                _ =— include: *    ,  '—=  ,  '—=  = or    ^ . In one embodiment, the alkynyl is optionally substituted alkynyl as described elsewhere herein. The term "alkynylene" refers to alkynyl in which one hydrogen atom is further substituted, wherein the "alkynyl" is as defined above. In one embodiment, the alkynylene is optionally substituted alkyl as described elsewhere herein. The term "cycloalkyl" refers to a saturated or partially unsaturated aliphatic hydrocarbon cyclic group, which may be monocyclic or polycyclic (containing two or more rings), and which may be optionally substituted with one or more substituents. In particular embodiments, the cycloalkyl ring contains 3 to 20 (C3-20), 3 to 14 (C3-14), 3 to 12 (C3-12), 3 to 8 (C3-8) or 3 to 6 (C3-6) carbon atoms. In one embodiment, the cycloalkyl ring contains 6 to 14 (C6-14) or 7 to 10 (C7-10) carbon atoms; it may contain one or more double bonds, but does not have a completely conjugated n electron system. Non-limiting examples of monocyclic cycloalkyl include cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cyclohexadienyl, cycloheptyl, cycloheptatrienyl, cyclooctyl, etc.; and polycyclic cycloalkyl includes spirocycloalkyl, fused cycloalkyl and bridged cycloalkyl in one embodiment. In one embodiment, the cycloalkyl is optionally substituted cycloalkyl as described elsewhere herein or cycloalkyl that is optionally fused to heterocyclyl, aryl or heteroaryl, and non-limiting examples include indanyl, tetrahydronaphthyl, benzocycloheptyl, etc. The term “spirocycloalkyl” refers to an aliphatic hydrocarbon polycyclic group with monocyclic rings sharing one carbon atom (called a spiro atom); and it may contain one or more double bonds, but no ring has a completely conjugated n electron system. In particular embodiments, the spirocycloalkyl contains 5 to 20 (C5-20), 6 to 14 (C6-14) or 7 to 10 (C7-10) (e.g., 7, 8, 9 or 10) carbon atoms. According to the number of shared spiro atoms between the rings, the spirocycloalkyl is divided into monospirocycloalkyl, bispirocycloalkyl or polyspirocycloalkyl. In one embodiment, the spirocycloalkyl is monospirocycloalkyl and bispirocycloalkyl. In one embodiment, the spirocycloalkyl is 4-membered / 4-membered, 3-membered / 5-membered, 4-membered / 5-membered, 4-membered / 6-membered, 5-membered / 5-membered or 5-membered / 6-membered monospirocycloalkyl. In one embodiment, the spirocycloalkyl is optionally substituted spirocycloalkyl as described elsewhere herein. Non-limiting examples of spirocycloalkyl include: Ja / i                 _L_,               uwv                                              ■ i                                                                                                                              ।                                                                                                                                                                i . The term “fused cycloalkyl” refers to an all-carbon polycyclic group with each ring in the system sharing a pair of adjacent carbon atoms with another ring in the system, wherein one or more rings may contain one or more double bonds, but no ring has a completely conjugated n electron system. In particular embodiments, the fused cycloalkyl contains 5 to 20 (C5-20), 6 to 14 (C6-14) or 7 to 10 (C7-10) (e.g., 7, 8, 9 or 10) carbon atoms. According to the number of constituent rings, the fused cycloalkyl can be divided into bicyclic, tricyclic, tetracyclic or polycyclic fused cycloalkyl. In one embodiment, the fused cycloalkyl is bicyclic or tricyclic, and in a further embodiment, the fused cycloalkyl is 3-membered / 5-membered, 4-membered / 5-membered, 5-membered / 5-membered or 5-membered / 6-membered bicyclic cycloalkyl. In one embodiment, the fused cycloalkyl is optionally substituted fused cycloalkyl as described elsewhere herein, or fused cycloalkyl that is optionally fused to heterocyclyl, aryl or heteroaryl. Non-limiting examples of fused cycloalkyl include: ns!> ? , '              ,         -          ,            y ,            --y ,             * or The term “bridged cycloalkyl” refers to an all-carbon polycyclic group in which any two rings share two carbon atoms that are not directly connected; and it may contain one or more double bonds, but no ring has a completely conjugated n electron system. In particular embodiments, the bridged cycloalkyl contains 5 to 20 (C5-20), 6 to 14 (C6-14) or 7 to 10 (C7-10) (e.g., 7, 8, 9 or 10) carbon atoms. According to the number of constituent rings, the bridged cycloalkyl can be divided into bicyclic, tricyclic, tetracyclic or polycyclic bridged cycloalkyl, preferably bicyclic or tricyclic. In one embodiment, the bridged cycloalkyl is optionally substituted bridged cycloalkyl as described elsewhere herein. Non-limiting examples of bridged cycloalkyl include: The term “cycloalkylene” refers to divalent cycloalkyl formed by further substituting one hydrogen atom on cycloalkyl, wherein the cycloalkylene is optionally substituted or unsubstituted, and the cycloalkyl is as defined above. The term "heterocyclyl" refers to a saturated or partially unsaturated monocyclic or polycyclic cyclic hydrocarbon group, wherein one or more ring atoms are heteroatoms selected from nitrogen, oxygen, boron, phosphorus or sulphur, wherein the nitrogen, phosphorus or sulphur atom may be optionally oxidised, the nitrogen atom may be optionally quaternised, the ring carbon atoms may be optionally substituted with oxygen, but excluding ring moieties of -O-O- and -O-S-, and the remaining ring atoms are carbon atoms. The heterocyclyl may contain one or more double bonds but do not have a completely conjugated n electron system. In particular embodiments, the heterocyclyl contains 3 to 20, 3 to 14, 5 to 14, 7 to 14, 3 to 12, 5 to 12, 7 to 12, 7 to 10, 3 to 8 or 3 to 6 ring atoms, of which 1 to 4 are heteroatoms. In one embodiment, the heterocyclyl contains 3 to 6, 4 to 6, 3 to 8, 3 to 10, 6 to 10 or 7 to 11 ring atoms. In one embodiment, the heterocyclyl contains 3 to 8 (e.g., 3, 4, 5, 6, 7 or 8) or 7 to 12 (e.g., 7, 8, 9, 10, 11 or 12) ring atoms. Nonlimiting examples of monocyclic heterocyclyl include tetrahydropyrrolyl, azetidinyl, oxetanyl, oxanyl, tetrahydrofuryl, tetrahydropyranyl, tetrahydrothienyl, dihydroimidazolyl, dihydrofuryl, dihydropyrazolyl, dihydropyrrolyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperazinyl, pyranyl, etc. Polycyclic heterocyclyl includes spiroheterocyclyl, fused heterocyclyl and bridged heterocyclyl. In one embodiment, the heterocyclyl is optionally substituted heterocyclyl as described elsewhere herein, or heterocyclyl that is further fused to other cycloalkyl, heterocyclyl, aryl and heteroaryl through any two or more atoms on the ring. The term "spiroheterocyclyl" refers to a polycyclic heterocyclic group in which the rings share one atom (called a spiro atom), wherein one or more ring atoms are heteroatoms selected from nitrogen, oxygen, boron, phosphorus or sulphur, and the remaining ring atoms are carbon atoms. The spiroheterocyclyl may contain one or more double bonds, but no ring has a completely conjugated n electron system. In particular embodiments, the spiroheterocyclyl contains 5 to 20 or 6 to 14 ring atoms. In one embodiment, the spiroheterocyclyl contains 7 to 11 (e.g., 7, 8, 9, 10 or 11) ring atoms. According to the number of shared spiro atoms between the rings, the spiroheterocyclyl is divided into monospiroheterocyclyl, bispiroheterocyclyl or polyspiroheterocyclyl, preferably monospiroheterocyclyl and bispiroheterocyclyl. In one embodiment, the spiroheterocyclyl is 4-membered / 4-membered, 4-membered / 5-membered, 4-membered / 6-membered, 5-membered / 5-membered or 5- membered / 6-membered monospiroheterocyclyl. In one embodiment, the spiroheterocyclyl is optionally substituted spiroheterocyclyl as described elsewhere herein. Non-limiting examples of spiroheterocyclyl include: v , '—1  or \— / . The term "fused heterocyclyl" refers to a polycyclic heterocyclic group with each ring in the system sharing a pair of adjacent atoms with another ring in the system, and one or more rings may contain one or more double bonds, but no ring has a completely conjugated n electron system, wherein one or more ring atoms are heteroatoms selected from nitrogen, oxygen, boron, phosphorus or sulphur, and the remaining ring atoms are carbon atoms. In particular embodiments, the fused heterocyclyl contains 5 to 20 or 6 to 14 ring atoms, and in one embodiment, the fused heterocyclyl contains 7 to 10 (e.g., 7, 8, 9 or 10) ring atoms. According to the number of constituent rings, the fused heterocyclyl can be divided into bicyclic, tricyclic, tetracyclic or polycyclic fused heterocyclyl, preferably bicyclic or tricyclic. In one embodiment, the fused heterocyclyl is 5-membered / 5-membered or 5-membered / 6-membered bicyclic fused heterocyclyl. In one embodiment, the fused heterocyclyl is optionally substituted fused heterocyclyl as described elsewhere herein, or fused heterocyclyl that can be fused to cycloalkyl, heterocyclyl, aryl or heteroaryl. Non- limiting examples of fused heterocyclyl include: HN The term "bridged heterocyclyl" refers to a polycyclic heterocyclic group with any two rings sharing two atoms that are not directly connected. The bridged heterocyclyl may contain one or more double bonds, but no ring has a completely conjugated n electron system, wherein one or more ring atoms are heteroatoms selected from nitrogen, oxygen, boron, phosphorus or sulphur, and the remaining ring atoms are carbon atoms. In particular embodiments, the bridged heterocyclyl contains 5 to 20 or 6 to 14 ring atoms. In one embodiment, the bridged heterocyclyl contains 7 to 10 (e.g., 7, 8, 9 or 10) ring atoms. According to the number of constituent rings, the bridged heterocyclyl can be divided into bicyclic, tricyclic, tetracyclic or polycyclic bridged heterocyclyl, preferably bicyclic, tricyclic or tetracyclic. In one embodiment, the bridged heterocyclyl is bicyclic or tricyclic. In one embodiment, the bridged heterocyclyl is optionally substituted bridged heterocyclyl as described elsewhere herein. Non-limiting examples of bridged heterocyclyl include: or The term “tricyclic heterocyclyl” refers to a heterocyclyl group having three rings in the system, wherein the three rings may be a fused ring system, a spiro ring system, or a bridged ring system. In one embodiment, at least one of the three rings in the tricyclic heterocyclyl system is heterocyclyl, and the other two rings may be cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl or heteroaryl is as defined above.Non-limiting examples thereof preferably include the following tricyclic heterocyclyl: The term “heterocyclylene” refers to divalent heterocyclyl formed by further substituting one hydrogen atom on heterocyclyl, wherein the heterocyclylene is optionally substituted or unsubstituted, and the heterocyclyl is as defined above. The term "aryl" refers to an all-carbon monocyclic or fused polycyclic (i.e., rings sharing a pair of adjacent carbon atoms) group containing at least one conjugated n electron system, which may be optionally substituted with one or more substituents. In particular embodiments, the aryl contains 6 to 20, 6 to 14, 6 to 12 or 6 to 10 ring atoms. In one embodiment, the aryl may further refer to a bicyclic, tricyclic or tetracyclic ring system, in which at least one ring is an aromatic ring and the other rings may be saturated or partially unsaturated carbocyclic rings or rings containing one or more heteroatoms independently selected from O, S and N. In one embodiment, the aryl is selected from benzo 5- to 10-membered heteroaryl, benzo 3- to 10-membered cycloalkyl or benzo 3- to 10-membered heterocyclyl. In one embodiment, the aryl is selected from benzo 5- or 6-membered heteroaryl, benzo 3-to 6-membered cycloalkyl or benzo 3- to 6-membered heterocyclyl, wherein the heterocyclyl is heterocyclyl containing 1 to 3 nitrogen atoms, oxygen atoms or sulphur atoms. Non-limiting examples thereof include phenyl, naphthyl, fluorenyl, azulenyl, anthryl, phenanthrenyl, pyrenyl, biphenyl, terphenyl, dihydronaphthyl, indenyl, tetrahydronaphthyl (tetralinyl), The term “arylene” refers to divalent aryl formed by further substituting one hydrogen atom on aryl, wherein the arylene is optionally substituted or unsubstituted, and the aryl is as defined above. The term "heteroaryl" refers to an optionally substituted monocyclic or polycyclic group or ring system containing at least one aromatic ring, wherein the aromatic ring has one or more heteroatoms independently selected from O, S and N. In particular embodiments, the heteroaryl contains 5 to 20, 5 to 14, 5 to 12 or 5 to 10 ring atoms, of which 1 to 4 are heteroatoms. In one embodiment, the heteroaryl contains 5 or 6 ring atoms. In particular embodiments, the heteroaryl may further refer to a bicyclic, tricyclic or tetracyclic ring, in which at least one ring is an aromatic ring having one or more heteroatoms independently selected from O, S and N, and the other rings may be saturated or partially unsaturated carbocyclic rings or rings containing one or more heteroatoms independently selected from O, S and N. In one embodiment, the heteroaryl is selected from heteroaryl fused 6- to 10membered aryl, heteroaryl fused 3- to 10-membered cycloalkyl, or heteroaryl fused 3- to 10-membered heterocyclyl. Further in one embodiment, the heteroaryl is selected from 5- or 6-membered heteroaryl fused 6- to 10-membered aryl, 5- or 6membered heteroaryl fused 3- to 6-membered cycloalkyl, or 5- or 6-membered heteroaryl fused 3- to 6-membered heterocyclyl, wherein the heterocyclyl is heterocyclyl containing 1 to 3 nitrogen atoms, oxygen atoms or sulphur atoms. Nonlimiting examples thereof include: furyl, imidazolyl, isothiazolyl, isoxazolyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidyl, pyrrolyl, thiadiazolyl, thiazolyl, thienyl, tetrazolyl, triazinyl, triazolyl, benzofuryl, benzoimidazolyl, benzisoxazolyl, benzopyranyl, benzothiadiazolyl, benzothienyl, nenzophenylthio, benzothienyl, benzotriazolyl, imidazopyridyl, imidazothiazolyl, indolizinyl, indolyl, indazolyl, isobenzofuryl, isobenzothienyl, isoindolyl, isoquinolyl, naphthyridinyl, oxazolopyridyl, phthalazinyl, pteridyl, purinyl, pyridopyridyl, pyrrolopyridyl, quinolyl, quinoxalinyl, quinazolinyl, thiadiazolopyrimidyl, thienopyridyl, acridyl, benzoindolyl, carbazolyl, dibenzofuryl, phenanthrolinyl, phenanthridinyl, phenarsazinyl, phenazinyl, phenothiazinyl, phenoxazinyl, xanthenyl, The term “heteroarylene” refers to divalent heteroaryl formed by further substituting one hydrogen atom on cycloalkyl, wherein the heteroarylene is optionally substituted or unsubstituted, and the heteroaryl is as defined above. The term "heteroalkyl" refers to a stable linear or branched, or cyclic hydrocarbon group, or a combination thereof, and is composed of the indicated number of carbon atoms and one or more (in one embodiment, one to three) heteroatoms selected from O, N, Si and S, wherein the nitrogen and sulphur atoms are optionally oxidised and the nitrogen heteroatom may be optionally quaternised. In one embodiment, the heteroatoms O, N and S may be placed at any interior position of the heteroalkyl group. In one embodiment, the heteroatom Si may be placed at any position (e.g., interior or terminal position) of the heteroalkyl group, including the position where the alkyl group is connected to the rest of the molecule. Non-limiting examples thereof include: -CH2-CH2-O-CH3, -CH2-CH2-NH-CH3, -CH2-CH2-N (CH3)-CH3, -CH2-S-CH2-CH3, -CH2-CH2-S(O)-CH3, -CH2-CH2-S(O)2-CH3, -CH=CH-O-CH3, -Si (CH3)3, -CH2-CH=N-OCH3 and-CH=CH-N (CH3)-CH3. Up to two heteroatoms can be consecutive, for example, -CH2-NH-O-CH3 and -CH2-O-Si(CH3)3. In particular embodiments, the heteroalkyl is optionally substituted heteroalkyl as described elsewhere herein. The term "alkoxy" refers to -O-(alkyl) and -O-(unsubstituted cycloalkyl), wherein the alkyl or cycloalkyl is as defined above. Non-limiting examples of alkoxy include:  methoxy, ethoxy, propoxy, butoxy, cyclopropoxy, cyclobutoxy, cyclopentyloxy or cyclohexyloxy. In one embodiment, the alkoxy is optionally substituted alkoxy as described elsewhere herein. The term "alkylacyl" refers to -C(O)-alkyl, wherein the alkyl is as defined above. The term "haloalkyl" refers to alkyl substituted with one or more halogen, wherein the alkyl is as defined above. Non-limiting examples of haloalkyl include: F         F trifluoromethyl, -CH2CF3,      F , or      F . The term "haloalkoxy" refers to alkoxy substituted with one or more halogen, wherein the alkoxy is as defined above. The term "hydroxyalkyl" refers to alkyl substituted with hydroxyl, wherein the alkyl is as defined above. The term "alkylthio" refers to -S-(alkyl) and -S-(unsubstituted cycloalkyl), wherein the alkyl or cycloalkyl is as defined above. Non-limiting examples of alkylthio include: methylthio, ethylthio, propylthio, butylthio, cyclopropylthio, cyclobutylthio, cyclopentylthio or cyclohexylthio. In one embodiment, the alkylthio is optionally substituted alkylthio as described elsewhere herein. The term "haloalkylthio" refers to alkylthio substituted with one or more halogen, wherein the alkylthio is as defined above. The term "alkenylcarbonyl" refers to -C(O)-(alkenyl), wherein the alkenyl is as defined above. Non-limiting examples of alkenylcarbonyl include: ethenylcarbonyl, propenylcarbonyl, or butenylcarbonyl. In one embodiment, the alkenylcarbonyl is optionally substituted alkenylcarbonyl as described elsewhere herein. The term "aminocarbonyl" refers to NH2-C(O)-. The term “alkylaminocarbonyl” refers to aminocarbonyl (NH2-C(O)-) in which one or both of the hydrogenare substituted with alkyl, wherein the alkyl is as defined above. The term "alkylamino" refers to amino in which one or both of the hydrogen are substituted with alkyl, wherein the alkyl is as defined above. The term "carbonyl" refers to a -C(O)-, -(CO)- or -C(=O)- group. All the symbols are used interchangeably in the description. The term "halogen" refers to fluorine, chlorine, bromine or iodine. The term "oxo" or "side oxygen" refers to =O. X The term “C(X)” or “C(=X)” refers to       group. When X is O, it indicates that the group is carbonyl; when X is S, it indicates that the group ismercapto; when u N X is NR, it indicates that the group is’     ; when X is CRR, it indicates that the R , R C group is A The term "hydrogen" includes proton (1H), deuterium (2H), tritium (3H) and / or a mixture thereof. In particular embodiments, one or more hydrogen-occupied positions in the compound may be enriched with deuterium and / or tritium. Such isotopically enriched analogues may be prepared from suitable isotopically labelled starting materials obtained from commercial sources or by known literature procedures. The alkyl, alkylene, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, arylene, heteroaryl, heteroarylene, heteroalkyl, alkoxy, alkylthio, hydroxyalkyl, alkenylcarbonyl, aminocarbonyl, alkylaminocarbonyl, alkylamino or alkylacyl may be substituted or unsubstituted. In one embodiment, the substituent is selected from one or more of the following groups: alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylamino, alkylacyl, halogen, mercapto, hydroxyl, nitro, cyano, azidyl, oximido, phosphate group, oxo, thio, carboxyl, carboxylate group, cycloalkyl, heterocyclyl, aryl, heteroaryl, heterocycloalkoxy, cycloalkylthio or heterocycloalkylthio. Different expressions such as "X is selected from A, B, or C", "X is selected from A, B and C", "X is A, B or C", and "X is A, B and C" all express the same meaning, that is, X can be any one or more of A, B, and C. "Optional" or "optionally" means that the event or circumstance subsequently described may but not necessarily occur, and the description includes the occasion where the event or circumstance occurs or does not occur. For example, “heterocyclic group optionally substituted with alkyl” means the alkyl may but need not be present, the description includes the case where the heterocyclic group is substituted with alkyl and the case where the heterocyclic group is not substituted with alkyl. In various parts of the present invention, linking substituents are described. When it is clear that a linking group is required for the structure, the markush variables listed for that group should be understood as referring to the linking group. For example, if a linking group is required for the structure and the markush group definition for that variable lists "alkyl" or "aryl," it should be understood that the "alkyl" or "aryl" respectively represents the attached alkylene group or arylene group. The term “substituted” means that any one or more hydrogen atoms on the designated atom are substituted with a substituent, provided that the valence state of the designated atom is normal, and the substituted compound is stable in one embodiment. When the substituent is oxo (i.e., =O), it means that two hydrogen atoms are substituted. The term "optionally substituted" means that a group may or may not be substituted. Unless otherwise specified, the type and number of substituents may be arbitrary on the basis of chemical practicability. It goes without saying, the substituents may be only in possible chemical positions thereof, and those skilled in the art can determine the possible or impossible substitutions (by experiment or theory) without paying too much effort. For example, an amino or hydroxyl group with free hydrogen may be unstable when attached to a carbon atom with an unsaturated (e.g., olefinic) bond. The substituents can be selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, oxo, thio, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cyano-substituted alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl. The term “substituted or unsubstituted” means that a group may or may not be substituted. When a group may be substituted, the substituents are selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -SF5, -C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, C(O)R, C(O)OR, C(O)NRR’, N=S(O)RR’, S(O)R(=NR’), P(O)RR’ or =RR’; R and R’ are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, - -C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl. Unless stated to the contrary, the indefinite articles "a" and "an" and the definite article "the" in the present description and claims include plural as well as singular forms. "Pharmaceutical composition" denotes a mixture containing one or more compounds described herein or physiologically / pharmaceutically acceptable salts or prodrugs thereof and other chemical components, as well as other components, such as physiologically / pharmaceutically acceptable carriers and excipients. The purpose of pharmaceutical compositions is to facilitate administration to living organisms and facilitate the absorption of active ingredients to exert biological activity. The “pharmaceutically acceptable salt” refers to salts of the compound of the present invention, which are safe and effective when used in mammals, and have appropriate biological activity. The               "stereoisomer"               comprises               all enantiomerically / diastereomerically / stereoisomerically         pure         and enantiomerically / diastereomerically / stereoisomerically enriched compounds of the present invention. "Stereoisomerically pure" means a composition comprising one stereoisomer of a compound and being substantially free of another stereoisomer of the compound. For example, a stereoisomerically pure composition of a compound having one chiral centre will be substantially free of the opposite enantiomer of the compound. A stereoisomerically pure composition of a compound having two chiral centres will be substantially free of other diastereomers of the compound. A typical stereoisomerically pure compound comprises greater than about 80% by weight of one stereoisomer of the compound and less than about 20% by weight of another stereoisomer of the compound, greater than about 90% by weight of one stereoisomer of the compound and less than about 10% by weight of another stereoisomer of the compound, greater than about 95% by weight of one stereoisomer of the compound and less than about 5% by weight of another stereoisomer of the compound, greater than about 97% by weight of one stereoisomer of the compound and less than about 3% by weight of another stereoisomer of the compound, or greater than about 99% by weight of one stereoisomer of the compound and less than about 1% by weight of another stereoisomer of the compound. “Stereoisomerically enriched” means a composition comprising greater than about 55% by weight, greater than about 60% by weight, greater than about 70% by weight, or greater than about 80% by weight of one stereoisomer of a compound. “Enantiomerically pure” means a stereoisomerically pure composition of a compound having one chiral centre. Similarly, the term "enantiomerically enriched" refers to a stereomerically enriched composition of a compound having one chiral centre. "Optical activity" and "enantiomeric activity" mean a combination of molecules having an enantiomeric or diastereomeric excess of no less than about 50%, no less than about 70%, no less than about 80%, no less than about 90%, no less than about 91%, no less than about 92%, no less than about 93% , no less than about 94%, no less than about 95%, no less than about 96%, no less than about 97%, no less than about 98%, no less than about 99%, no less than about 99.5%, or no less than about 99.8%. In particular embodiments, the compound comprises about 95% or more of the desired enantiomer or diastereomer and about 5% or less of the less preferred enantiomer or diastereomer, based on the total weight of the racemate. When describing optically active compounds, the prefixes R and S are used to indicate the absolute configuration of the molecule relative to its chiral centre. (+) and (-) are used to represent the optical rotation of the compound, that is, the direction of the plane of polarised light rotated by the optically active compound. The prefix (-) indicates that the compound is levorotatory, that is, the compound rotates the plane of polarised light to the left or counterclockwise. The prefix (+) indicates that the compound is dextrorotatory, that is, the compound rotates the plane of polarised light to the right or clockwise. However, the signs of optical rotation (+) and (-) are independent of the absolute configurations R and S of the molecule. Detailed Description of Embodiments The present invention will be further described below in conjunction with examples, but these examples are not meant to limit the scope of the present invention. Example The structures of the compounds of the present invention are determined by nuclear magnetic resonance (NMR) or / and mass spectrometry (MS). The NMR shift (8) is given in 10-6 (ppm). NMR is determined with a Bruker AVANCE-400 nuclear magnetic instrument. The solvents for determination are deuterated dimethyl sulphoxide (DMSO-d6), deuterated chloroform (CDCl3), and deuterated methanol (CD3OD), and the internal standard is tetramethylsilane (TMS). MS is determined with a FINNIGAN LCQAd (ESI) mass spectrometer (manufacturer: Thermo, model: Finnigan LCQ advantage MAX). HPLC is determined with Agilent 1200DAD high-pressure liquid chromatograph instrument (Sunfire C18 150 x 4.6 mm chromatographic column) and Waters 2695-2996 high-pressure liquid chromatograph instrument (Gimini C18 150 x 4.6 mm chromatographic column). The average kinase inhibition rate and IC50 value are determined with NovoStar microplate reader (BMG Company, Germany). For thin layer chromatography (TLC), silica gel plates from Yantai Huanghai HSGF254 or Qingdao GF254 are used. Silica gel plates with a thickness of 0.15 mm-0.2 mm are employed for TLC, while plates with a thickness of 0.4 mm-0.5 mm are used for TLC separation and purification. For column chromatography, Yantai Huanghai silica gel of 200-300 mesh is typically used as a carrier. The known starting materials of the present invention can be synthesised by methods known in the art, or can be purchased from ABCR GmbH & Co. KG, Acros Organics, Aldrich Chemical Company, Accela ChemBio Inc., Chembee Chemicals Inc. and other companies. Unless otherwise specially specified in examples, reactions can all be carried out under argon atmosphere or nitrogen atmosphere. Argon atmosphere or nitrogen atmosphere means that a reaction flask is connected to an argon or nitrogen balloon with a volume of about 1 L. Hydrogen atmosphere means that a reaction flask is connected to a hydrogen balloon with a volume of about 1 L. Pressurised hydrogenation reactions are performed using either Parr 3916EKX hydrogenation apparatus with Qinglan QL-500 hydrogen generator or HC2-SS hydrogenation apparatus. Hydrogenation reactions are typically performed by evacuating the system and refilling it with hydrogen gas, repeating this operation three times. Microwave reactions are performed using CEM Discover-S 908860 microwave reactor. Unless otherwise specially specified in examples, a solution refers to an aqueous solution. Unless otherwise specially specified in examples, the reaction temperature is room temperature, which is 20°C to 30°C. The progress of a reaction in the examples is monitored by thin layer chromatography (TLC). Developing agent systems used in the reaction include: A: dichloromethane and methanol system, B: n-hexane and ethyl acetate system, C: petroleum ether and ethyl acetate system, D: acetone, the volume ratio of the solvents is adjusted according to the polarity of the compounds. Eluent systems for column chromatography and developing agent systems for thin layer chromatography, which are used to purify compounds, include: A: n-hexane and ethyl acetate system, B: n-hexane and tetrahydrofuran system, the volume ratio of the solvents is adjusted according to the polarity of the compounds, and a small amount of basic or acidic reagents such as triethylamine and acetic acid can also be added for adjustment. The chiral preparative HPLC conditions in the examples are as follows, wherein tR represents retention time: Chiral preparative conditions: Instrument WATERS 150 Mgm preparative SFC Column type ChiralCel AD, 250*30 mm I.D., 10 pm Column pressure 100 bar Mobile phase A for CO2 and B for Ethanol, B 40% Flow rate 100 mL / min Detection wavelength UV 254 nm Column temperature 39°C Chiral analysis conditions: Instrument Waters Acquity UPC2 Column type Chiralcel AD-3 50*4.6 mm I.D., 3 um Column pressure 120 bar Mobile phase A for CO2 and B for Ethanol (0.05% DEA), 40% Flow rate 2.5 mL / min Detection wavelength UV 254 nm Column temperature 25°C The compounds in the embodiments of the present invention are prepared with reference to the preparation steps of the following examples: Example 1 4-Amino-1-methyl-10-(2-trifluoromethyl-5,8-dihydro-6H-pyrano[3,4- 5      b]pyridin-5-yl)-7,8,9,10-tetrahydroazepino[3,4-g]pyrazolo[4,3-c]quinolin- 11(1H)-one Step 1: Methyl 4-amino-2-bromo-carboxylate 1a (10.00 g, 43.67 mmol) and N-iodosuccinimide (10.13 g, 45.00 mmol) were dispersed in acetonitrile (100 mL). The 10 mixture was stirred and reacted at 25°C for 16 hours. The reaction solution was filtered to remove insoluble materials. The filtrate was concentrated under reduced pressure to dryness, and the resulting residue was purified by silica gel column chromatography using eluent system A to obtain 1b (14.00 g, yield: 90.3%). MS m / z (ESI): 356 [M+1]+ 15        Step 2: 1b (9.00 g, 25.35 mmol), 1-methyl-1H-pyrazole-5-boronic acid pinacol ester (10.55 g, 50.70 mmol), [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (1.86 g, 2.54 mmol), and potassium phosphate (10.75 g, 50.70 mmol) were dispersed in 1,4-dioxane (150 mL) and water (30 mL). The mixture was stirred and reacted at 80°C for 16 hours. The reaction solution was filtered to remove insoluble materials. The filtrate was concentrated under reduced pressure to dryness, and the resulting residue was purified by silica gel column chromatography using eluent system A to obtain 1c (6.50 g, yield: 83.0%). MS m / z (ESI): 310 [M+1]+ Step 3: 1c (6.50 g, 21.04 mmol) and N,N'-carbonyldiimidazole potassium phosphate (6.82 g, 42.08 mmol) were dispersed in N-methylpyrrolidone (65 mL). The mixture was stirred and reacted at 150°C for 1 hour. The reaction solution was poured into water (650 mL), and the precipitated solid was filtered to obtain 1d (5.71 g, yield: 81.0%). MS m / z (ESI): 336 [M+1]+ Step 4: 1d (5.71 g, 17.04 mmol), 2,4-dimethoxybenzylamine (5.69 g, 34.08 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (5.18 g, 34.08 mmol) and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (15.06 g, 34.08 mmol) were dispersed in dimethyl sulphoxide (50 mL). The mixture was stirred and reacted at 25°C for 1 hour. The reaction solution was poured into water (500 mL), and the precipitated solid was filtered to obtain 1e (6.41 g, yield: 77.7%). MS m / z (ESI): 486 [M+1]+ Step 5: 1e (5.2 g, 10.72 mmol), 4,4,5,5-tetramethyl-2-(3-(tetrahydro-2H-pyran-2-yl)oxy)propyl)-1,3,2-dioxaborolane (4.3 g, 13.19 mmol), [n-butyl-di(1-adamantyl)phosphine](2-amino-1,1'-biphenyl-2-yl)palladium(II) methanesulphonate (800 mg, 1.10 mmol), and caesium carbonate (5.37 g, 16.48 mmol) were dissolved in dioxane (60 mL) and water (15 mL), and the mixture was reacted under microwave irradiation at 110°C under nitrogen atmosphere for 2 hours. Water (100 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (100 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 1f (3.3 g, yield: 51.7%). MS m / z (ESI): 549 [M+1]+ Step 6: 1f (3.3 g, 6.01 mmol) was dissolved in methanol (60 mL), trifluoroacetic acid (12 mL) was added, and the mixture was stirred and reacted at room temperature for 2 hours. The reaction solution was adjusted to pH=8-9 with a sodium bicarbonate aqueous solution, extracted with dichloromethane (containing 10% methanol, 100 mLx2), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 1g (2.2 g, yield: 78.9%). MS m / z (ESI): 465 [M+1]+ Step 7: 1g (2.2 g, 4.74 mmol) was dissolved in dichloromethane (120 mL), and the mixture was purged three times with nitrogen and cooled to 0°C. Triphenylphosphine (2.49 g, 9.48 mmol) and carbon tetrabromide (3.14g, 9.48 mmol) were then added, and the system was reacted at 25°C for 2 hours. The reaction solution was distilled under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 1h (1.92 g, yield: 77.1%). MS m / z (ESI): 527 [M+1]+ Step 8: 1h (543 mg, 1.03 mmol), 2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-amine (270 mg, 1.24 mmol), sodium iodide (309 mg, 2.06 mmol) and potassium carbonate (427 mg, 3.09 mmol) were dissolved in acetonitrile (60 mL), and the mixture was purged three times with nitrogen. The reaction system was reacted at 80°C for 15 hours. The reaction solution was quenched with water, extracted with ethyl acetate (50 mL x 2), and washed with a saturated sodium chloride aqueous solution (50 mL x 2). The organic phase was dried over anhydrous sodium sulphate, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 1i (351 mg, yield: 51.3%). MS m / z (ESI): 665 [M+1]+ Step 9: 1i (351 mg, 0.53 mmol) was dissolved in tetrahydrofuran (5 mL), water (5 mL) and methanol (5 mL), lithium hydroxide (63 mg, 2.64 mmol) was added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 25°C for 16 hours. The resulting reaction system was adjusted to pH 5-6 with 1 M dilute hydrochloric acid, extracted with ethyl acetate (50 mL x 3), and washed with a saturated sodium chloride aqueous solution (50 mL x 2). The organic phase was dried over anhydrous sodium sulphate, and the filtrate was concentrated under reduced pressure to obtain 1j (237 mg, yield: 68.7%). MS m / z (ESI): 651 [M+1]+ Step 10: 1j (234 mg, 0.36 mmol) and 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (68 mg, 0.54 mmol) were dissolved in N,N-dimethylformamide (20 mL), N,N-diisopropylethylamine (93 mg, 0.72 mmol, 72 pL) was added, and the reaction system was reacted at 25°C for 48 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (80 mL x 3), washed with a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulphate, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography using eluent system A to obtain 1k (122 mg, yield: 53.9%). MS m / z (ESI): 633 [M+1]+ Step 11: 1k (122 mg, 0.19 mmol) was dissolved in trifluoroacetic acid (2 mL), and the reaction system was reacted at 90°C for 0.5 hours. The resulting reaction system was concentrated, and the residue was purified by silica gel column chromatography using eluent system A to obtain Example 1 (47 mg, yield: 50.5%). MS m / z (ESI): 483 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.23 (s, 1H), 8.33 (dd, 1H), 8.22 (s, 1H), 8.08 (br s, 2H), 7.87 (dd, 1H), 7.44 (d, 1H), 6.71 (t, 1H), 5.63-5.36 (m, 1H), 4.894.70 (m, 2H), 4.47-4.13 (m, 2H), 3.94-3.64 (m, 2H), 3.09 (dd, 2H), 2.18-1.91 (m, 2H). Examples 1-P1 & 1-P2 Example 1 (45 mg, 0.093 mmol) was separated by chiral preparative HPLC to obtain           rel-(S)-4-amino-1-methyl-10-(2-trifluoromethyl-5,8-dihydro-6H- pyrano[3,4-b]pyridin-5-yl)-7,8,9,10-tetrahydroazepino[3,4-g]pyrazolo[4,3-c]quinolin-11(1H)-one 1-P1 (21 mg, yield: 46.7%) and rel-(R)-4-amino-1-methyl-10-(2-trifluoromethyl-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-7,8,9,10-tetrahydroazepino[3,4-g]pyrazolo[4,3-c]quinolin-11(1H)-one 1-P2 (21 mg, yield: 46.7%). 1-P1: 1H NMR (400 MHz, DMSO-d6) 5 9.23 (s, 1H), 8.33 (dd, 1H), 8.22 (s, 1H), 8.08 (br s, 2H), 7.87 (dd, 1H), 7.44 (d, 1H), 6.71 (t, 1H), 5.63-5.36 (m, 1H), 4.89-4.70 (m, 2H), 4.47-4.13 (m, 2H), 3.94-3.64 (m, 2H), 3.09 (dd, 2H), 2.18-1.91 (m, 2H). 1-P2: 1H NMR (400 MHz, DMSO-d6) 5 9.23 (s, 1H), 8.33 (dd, 1H), 8.22 (s, 1H), 8.08 (br s, 2H), 7.87 (dd, 1H), 7.44 (d, 1H), 6.71 (t, 1H), 5.63-5.36 (m, 1H), 4.89-4.70 (m, 2H), 4.47-4.13 (m, 2H), 3.94-3.64 (m, 2H), 3.09 (dd, 2H), 2.18-1.91 (m, 2H). The following examples were prepared by reference to Example 1: Example Structure MS m / z (ESI) [M+1]+ Example Structure MS m / z (ESI) [M+1]+ 2 h2n XA o x Ay o X^ 497 28 H2N X? N :- \ / X aA OCF3 0 \ / N 0^ 526 2-P1 h2n X O (yrr"’ X" 497 29 n 499 2-P2 Ox > ° ) ^^0CF3 o- 511 3-P1 tt? U \=z X C I        o \___ / xXo ^o X> 555 32 0 z=^       ® w X               \ / 513 3-P2 h2n xOn Ox O Xx 0 / 1 ox 555 33 h2n X? N   N"^ R >0 / =^\ / A xCF-’ \ / N 0^ 499 4 ACrAA / \ o       1 \ °V^J\ / z'z q 553 34 H2N z\ A" 483 4-P1 & / A ^A^O IrV'^ Z"^ s z^\=::A-_- / xA 553 35 CW / —y o %aA jr 485 4-P2 w \=z / -A M^O AzAJ ^A X   ^'v^ / x / 553 36 H,N W j N N^ • W" ^oz 495 5 A irV'A <zAJ ^A S         \„, / x   / 541 37 0               z A 525 6 HiNvAn va x y) / — / / =° /   r- N    / =y W\ / / CF3 \ / N o— / 525 38 H->N \ AN \ J N N^ coA" o 527 7 h2n W^n N kT JJ 5 ov 539 39 h2n \ ^N W j N  N^ X'," o 537 8 Qtf / \ o         1 > °vaa z=\ q 541 40 H2N      ,-. 2 \ ^^• A \ JI N A VrNv / =\ — / )—(\ \ / ^N 525 9 H2N \ / z~N t \ J N N*^ / -- / /             / ==A W\ / ^cf3 \ / N () 7 511 41 H2N     z. \      N nHP . - X--    )--X\ / ^CI?3 ( y n o— / 509 10 h2n \ J N O HN- XX / =\ V ■^r£y" O^   N 588 42 H2N - X--    )--<k / ^CF3 ( / N o— / 509 11 H,N \ A / v yy [ z— N   Z=\ y~\ ( ?”-n o^ 497 43 H,N N   N-^ . X--    )--\\   / ^CF3 ( /  N ' o—' 523 12 h2n / / \ j N N^ yy / ^° [       y=y / A \ / ^N O^' 511 44 HjN YX] N --   )--\ / ^CF3 ( ' o—7 523 13 H,N    ~ \ A N / V yy >o \ / y— N   / =\ / 4 ^CF* / N o— 509 45 H,N yx / — / / ^° N-N N / =\ \ N 535 14 H2N XXj N . z ! ^N / =\ M ^CF-’ ( / N o— 499 46 H,N    ~ ‘ \ z^N 4 \ J y) / —'  )=o / =\ N / =\ N-      )~\\ N ( / N O^' 536 15 h2m xX . ■-. 1 ^N / =\ / A ( / n 0^ 513 47 H,N    ~ X \ j N   N"^ . \|—y  N    / =y Nc       )--(\   / / ^CF3 N     ( 536 15-P1 h2n t \ J N rf ■ --o 515 48 H,N z. ' \___ / - N ..z / / =\ \ / N 513 15-P2 h2n    z. k-O N N"^ > f' ■ 515 49 HjN     z-. 2 \ Z^N / / \ J / N y) o—'  )=O --(, / =\ / 4 ^CF~’ 527 16 NZ >4 ।— O / —N / =\ )—4    cr3 \ / — 499 50 H2N     z-~ 2 \ / r~\ J N   N-^ yy / --'   )^o ° rN / ^x x— / )—4 / / CF-’ / — 513 17 H,N zs yrj N O r / 0 513 51 h2n / r~\ j N   N-^ yy / - / >o O    / — N / =\ / A *\ / N O— / 527 18 H,N \ Z^N / / \ 0 N N-^ . N         O 522 52 H,N ' \___ / / N Mj X hn^ y« °y n X--    / --(\ / ^ce3 ( / ^N 526 19 H,N     / - 2 \ VN VV J N yy r        / ° L       / =\ O- rCF1 o— 495 53 H2N     z. N N"^ N—2  )=O °y / —n W\ / Fcf3 ( / N 540 20 H,N    z-. W^N zv y) ^=0 / =\ / —(\ / / ^cf3 \ / N 495 54 H2N    z-. XV o Q / / =° HN        / =\ X--- / / ---4, ( / N O—'' 526 21 H2N \ V ^ / / X J N yy \[ / — N / =\ / ^CF3 \ / — o—' 509 55 H2N    Z-. o Q / )=o — N    / —N / = / / A ^CF3 \ / N O—' 540 22 2 \       N ft \ J N N yy r— A° 1 s— N / =\ \ / N O — 509 56 H,N J N N-^ y} / — )=° UN           / =\ ) /     y\ / / cf3 °      ( / - n o— 526 23 H,N \ n N ft \ J N N"^ ft HN^A yr- N   Z=\ °^ / X\\ Acf3 \ 512 57 H,N 2 \ ft \ J / N yy / — )^° — N        / =\ ftft / ftCF-’ ° \ / N 540 24 h2n 2 \ zz N A\ J) N N"^ yy °V>° HN^^Y / =\ Aa_ rCF’ ( A O—' 512 58 h2n ft^ J I) / -° / ^N / =\ ^X\ / YCF3 \ / ^N o—7 513 25 h2n \ ^N / r\ j N yy XN^ / =° )—<\     cf3 ( / N o— 526 59 H,N \ A N / ^° )=° v_aV / =\ nA Acf3 \ )—k o^z 511 26 H'N\Vn ft N^ Vft °V>o / =\ ftY / ftCF3 \ / N <1 -' 526 60 H,N     z. \ nN v^° A° Y / —N / =\ yA \ / n o—' 525 27 ftM HN^\ / =\ 1 XA / ^CF’ ° \ / N o— / 512 61 H2V^n A Vo >o \ / n X--    / -- / ACF3 \ / N o— / 527 Alternatively, Examples 14, 15, and 48 were synthesised by reference to the following preparation method: Example 14 4-Amino-12-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)- 9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazonino[8,7-g]quinoxalin-13(7H)- one Step 1: 3-((tert-Butyldimethylsilyl)oxy)propan-1-ol 14a (10 g, 52.53 mmol) was dissolved in tetrahydrofuran (100 mL), and sodium hydride (2.73 g, 68.29 mmol, 60% purity) was added in an ice bath. The mixture was stirred for 15 minutes, potassium (bromomethyl)trifluoroborate (10.02 g, 49.91 mmol) was then added, and the mixture was stirred and reacted at room temperature for about 16 hours. A potassium bifluoride solution (4.5 M) was added to the reaction solution, and the mixture was stirred at room temperature for 30 minutes. The reaction solution was subjected to rotary evaporation to dryness, and then hot acetone (1000 L) was added, and the resulting mixture was stirred at 80°C for about 15 minutes. After hot filtration to remove impurities, the acetone was distilled under reduced pressure until solids precipitated. Twice the volume of diethyl ether was added, and the mixture was filtered in an ice bath. The filter residue was dried to obtain 14b (4.3 g, yield: 26.4%). Step 2:   Methyl 7-bromo-4-((3,4-dimethoxybenzyl)amino)imidazo[1,5- a]quinoxaline-8-carboxylate (5.2 g, 10.99 mmol), potassium (8,8,9,9-tetramethyl-3,7-dioxa-8-sila-1-boradecan-1-yl)trifluoroborate 14b (4.3 g, 13.19 mmol), [n-butyl-di(1-adamantyl)phosphine](2-amino-1,1'-biphenyl-2-yl)palladium(II) methanesulphonate (800 mg, 1.10 mmol) and caesium carbonate (5.37 g, 16.48 mmol) were dissolved in dioxane (60 mL) and water (15 mL), and the mixture was reacted under microwave irradiation at 110°C under nitrogen atmosphere for 2 hours. Water (100 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (100 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 14c (3.3 g, yield: 50.5%). MS m / z (ESI): 595 [M+1]+ Step 3: 14c (3.3 g, 5.56 mmol) was dissolved in tetrahydrofuran (60 mL), tetrabutylammonium fluoride (2.90 g, 11.10 mmol, 2M in THF) was added, and the mixture was stirred and reacted at room temperature for 2 hours. The reaction was quenched by adding a saturated ammonium chloride solution (100 mL) to the reaction solution, and extracted with ethyl acetate (100 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 14d (1.5 g, yield: 56.3%). MS m / z (ESI): 481 [M+1]+ Step 4: 14d (1.5 g, 3.12 mmol) was dissolved in dichloromethane (120 mL), and the mixture was purged three times with nitrogen and cooled to 0°C. Triphenylphosphine (1.64 g, 6.24 mmol) and carbon tetrabromide (2.07g, 6.24 mmol) were then added, and the system was reacted at 25°C for 2 hours. The reaction solution was distilled under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 14e (630 mg, yield: 37.1%). MS m / z (ESI): 543 [M+1]+ Step 5: 14e (560 mg, 1.03 mmol), 2-(trifluoromethyl)-5,8-dihydro-6H- pyrano[3,4-b]pyridin-5-amine (270 mg, 1.24 mmol), sodium iodide (309 mg, 2.06 mmol) and potassium carbonate (427 mg, 3.09 mmol) were dissolved in acetonitrile (60 mL), and the mixture was purged three times with nitrogen. The reaction system was reacted at 80°C for 15 hours. The reaction solution was quenched with water, extracted with ethyl acetate (50 mL x 2), and washed with a saturated sodium chloride aqueous solution (50 mL x 2). The organic phase was dried over anhydrous sodium sulphate, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 14f (360 mg, yield: 51.3%). MS m / z (ESI): 681 [M+1]+ Step 6: 14f (350 mg, 0.51 mmol) was dissolved in tetrahydrofuran (5 mL), water (5 mL) and methanol (5 mL), lithium hydroxide (62 mg, 2.57 mmol) was added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 25°C for 16 hours. The resulting reaction system was adjusted to pH 5-6 with 1 M dilute hydrochloric acid, extracted with ethyl acetate (50 mL x 3), and washed with a saturated sodium chloride aqueous solution (50 mL x 2). The organic phase was dried over anhydrous sodium sulphate, and the filtrate was concentrated under reduced pressure to obtain 14g (125 mg, yield: 36.5%). MS m / z (ESI): 667 [M+1]+ Step 7: 14g (125 mg, 0.18 pmol) and 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (68 mg, 0.54 mmol) were dissolved in N,N-dimethylformamide (20 mL), N,N-diisopropylethylamine (93 mg, 0.72 mmol, 72 pL) was added, and the reaction system was reacted at 25°C for 48 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (80 mL x 3), washed with a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulphate, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography using eluent system A to obtain 14h (63 mg, yield: 53.9%). MS m / z (ESI): 649 [M+1]+ Step 8: 14h (63 mg, 0.10 mmol) was dissolved in trifluoroacetic acid (2 mL), and the reaction system was reacted at 90°C for 0.5 hours. The resulting reaction system was concentrated, and the residue was purified by silica gel column chromatography using eluent system A to obtain Example 14 (9.7 mg, yield: 19.4%). MS m / z (ESI): 499 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.23 (d, 1H), 8.33 (dd, 1H), 8.22 (s, 1H), 8.08 (s, 2H), 7.87 (dd, 1H), 7.44 (d, 1H), 5.63 - 5.36 (m, 1H), 4.89 - 4.70 (m, 3H), 4.47 - 4.13 (m, 3H), 3.94 - 3.64 (m, 2H), 3.09 (dd, 2H), 2.18 - 1.91 (m, 1H), 1.15 (d, 1H). Example 15 4-Amino-9-methyl-12-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazolo[8,7-g]quinoxalin-13(7H)-one Step 1: 4-Aminobutan-2-ol 15a (1.5 g, 16.83 mmol) and isobenzofuran-1,3-dione (2.99 g, 20.19 mmol) were dissolved in toluene (15 mL). The mixture was purged three times with nitrogen, and stirred and reacted at 120°C under nitrogen atmosphere for 16 hours. The reaction solution was concentrated under reduced pressure, and the concentrated residue was separated and purified by Pre-HPLC to obtain 15b (2.5 g, yield: 67.8%). MS m / z (ESI): 220 [M+1]+ Step 2: NaH (729.81 mg, 18.25 mmol, 60% purity) was suspended in DMF (10 mL), and the reaction system was cooled to 0°C. 15b (2 g, 9.12 mmol) / DMF (10 mL) was added, and the mixture was stirred at 0°C for 15 minutes. 2-(Iodomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (4.89 g, 18.25 mmol) / DMF (10 mL) was added, and the resulting mixture was purged three times with nitrogen, and stirred and reacted at 25°C under nitrogen atmosphere for 6 hours. Water (60 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (60 mL x 3). The organic phases were combined, washed with water (60 mL x 3), dried over anhydrous sodium sulphate, filtered, and concentrated under reduced pressure, and the concentrated residue was separated and purified by Pre-HPLC to obtain 15c (2 g, yield: 79.1%). MS m / z (ESI): 278 [M+1]+ Step 3: Methyl 7-bromo-4-[(2,4-dimethoxyphenyl)methylamino]imidazo[1,5-a]quinoxaline-8-carboxylate (1.5 g, 3.18 mmol) and [3-(1,3-dioxoisoindolin-2-yl)-1-methylpropoxy]methylboronic acid 15c (1.06 g, 3.82 mmol) were dissolved in 1'4-dioxane (15 mL) and water (1.5 mL), and cataCXium A Pd G3 (347.68 mg, 477 pmol) and CS2CO3 (3.11 g, 9.55 mmol) were sequentially added. The mixture was purged three times with nitrogen, and stirred and reacted under microwave irradiation at 110°C under nitrogen atmosphere for 1.5 hours. Water (60 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (60 mL x 3). The organic phases were combined, washed with water (60 mL x 3), dried over anhydrous sodium sulphate, filtered, and concentrated under reduced pressure, and the concentrated residue was separated and purified using purification system C to obtain 15d (3 g, yield: 25.2%). MS m / z (ESI): 624 [M+1]+ Step 4: 15d (3 g, 2.41 mmol) was dissolved in EtOH (30 mL), and NH2NH2 (181.35 mg, 4.81 mmol, 85% purity) was added. The mixture was purged three times with nitrogen, and stirred and reacted at 90°C under nitrogen atmosphere for 3 hours. The reaction solution was concentrated under reduced pressure, and the concentrated residue was separated and purified by Pre-HPLC to obtain 15e (470 mg, yield: 39.6%). MS m / z (ESI): 494 [M+1]+ Step 5:     [2-(Trifluoromethyl)-6,8-dihydro-5H-pyrano[3,4-b]pyridin-5- yl]methanesulphonate (100 mg, 336 umol) and 15e (182.64 mg, 370 umol) were dissolved in MeCN (10 mL), and Nai (100.85 mg, 673 pmol) and DIEA (86.96 mg, 673 umol, 117 uL) were sequentially added. The mixture was purged three times with nitrogen, and stirred and reacted at 80°C under nitrogen atmosphere for 16 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure to obtain 15f (155 mg, yield: 66.3%). MS m / z (ESI): 695 [M+1]+ Step 6: 15f (155 mg, 223 umol) was dissolved in THF (3 mL), MeOH (1 mL) and water (1 mL), and LiOH (21.37 mg, 892.47 umol) was added. The mixture was purged three times with nitrogen, and stirred and reacted at 25°C under nitrogen atmosphere for 16 hours. The reaction solution was concentrated under reduced pressure, dissolved in water (10 mL), adjusted to pH = 4-5 with 2 M dilute hydrochloric acid, and extracted with ethyl acetate (20 mL x 3). The organic phases were combined, dried over anhydrous sodium sulphate, filtered, and concentrated under reduced pressure to obtain 15g (52 mg, yield: 34.2%). MS m / z (ESI): 682 [M+1]+ Step 7: 15g (52 mg, 76 umol) was dissolved in DMF (5 mL), and DIEA (29.62 mg, 229 umol, 39.92 uL) and HATU (43.23 mg, 115 umol) were sequentially added. The mixture was purged three times with nitrogen, and stirred and reacted at 25°C under nitrogen atmosphere for 16 hours. The reaction solution was concentrated under reduced pressure to obtain 15h (50 mg, crude). Step 8: 15h (50 mg, 60 umol) was dissolved in TFA (2 mL), and the mixture was purged three times with nitrogen, and stirred and reacted at 80°C under nitrogen atmosphere for 0.5 hours. The reaction solution was concentrated under reduced pressure, and the concentrated residue was separated and purified by Pre-HPLC to obtain Example 15 (17 mg). MS m / z (ESI): 513 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.13 (s, 1H), 8.27 (d,1H), 7.99 (s, 1H), 7.90 (s, 1H), 7.85 (d, 1H), 7.37 (d, 3H), 5.38 (s, 1H), 4.92 - 4.71 (m, 3H), 4.50 - 4.35 (m, 2H), 4.26 (dd, 1H), 3.67 (d, 1H), 3.44 (dd, 1H), 1.32 - 1.03 (m, 3H), 0.94 (d, 3H). Examples 15-P1 & 15-P2 Example 15 (17 mg, 0.33 mmol) was separated by preparative HPLC to obtain an enantiomeric mixture of (R)-4-amino-9-methyl-12-((S)-2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazolo[8,7-g]quinoxalin-13(7H)-one and (S)-4-amino-9-methyl-12-((R)-2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazolo[8,7-g]quinoxalin-13(7H)-one (15-P1, 7.6 mg, yield: 44.7%) and an enantiomeric mixture of (R)-4-amino-9-methyl-12-((R)-2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazolo[8,7-g]quinoxalin-13(7H)-one and (S)-4-amino-9-methyl-12-((S)-2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazolo[8,7-g]quinoxalin-13(7H)-one (15-P2, 7.9 mg, yield: 46.5%). 15-P1: 1H NMR (400 MHz, DMSO-d6) 5 9.13 (s, 1H), 8.27 (d,1H), 7.99 (s, 1H), 7.90 (s, 1H), 7.85 (d, 1H), 7.37 (d, 3H), 5.38 (s, 1H), 4.92 - 4.71 (m, 3H), 4.50 - 4.35 (m, 2H), 4.26 (dd, 1H), 3.67 (d, 1H), 3.44 (dd, 1H), 1.32 - 1.03 (m, 3H), 0.94 (d, 3H). 15-P2: 1H NMR (400 MHz, DMSO-d6) 5 9.13 (s, 1H), 8.27 (d,1H), 7.99 (s, 1H), 7.90 (s, 1H), 7.85 (d, 1H), 7.37 (d, 3H), 5.38 (s, 1H), 4.92 - 4.71 (m, 3H), 4.50 - 4.35 (m, 2H), 4.26 (dd, 1H), 3.67 (d, 1H), 3.44 (dd, 1H), 1.32 - 1.03 (m, 3H), 0.94 (d, 3H). Example 48 4-Amino-13-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-10,11,12,13-tetrahydro-7H-imidazo[1,5-a][1,6]oxazino[3,4-g]quinoxalin-14(9H)-one Step 1: 4-((Tetrahydro-2H-pyran-2-yl)oxy)butan-1-ol 48a (6.6 g, 37.88 mmol) was dissolved in tetrahydrofuran (100 mL), and sodium hydride (1.52 g, 37.88 mmol, 60% purity) was added in an ice bath. The mixture was stirred for 15 minutes, potassium (bromomethyl)trifluoroborate (7.61 g, 37.88 mmol) was then added, and the mixture was stirred and reacted at room temperature for about 16 hours. A potassium bifluoride solution (4.5 M) was added to the reaction solution, and the mixture was stirred at room temperature for 30 minutes. The reaction solution was subjected to rotary evaporation to dryness, and then hot acetone (100 mL) was added, and the resulting mixture was stirred at 80°C for about 15 minutes. After hot filtration to remove impurities, the acetone was distilled under reduced pressure until solids precipitated. Twice the volume of diethyl ether was added, and the mixture was filtered in an ice bath. The filter residue was dried to obtain 48b (6.7 g, 22.78 mmol, yield: 60.1%). Step 2: 48b (1.25 g, 4.24 mmol), [n-butyl-di(1-adamantyl)phosphine](2-amino-1,1'-biphenyl-2-yl)palladium(II) methanesulphonate (309.05 mg, 424.36 pmol) and caesium carbonate (4.15 g, 12.73 mmol) were dissolved in dioxane (40 mL) and water (10 mL), and the mixture was reacted at 100°C under nitrogen atmosphere for 16 hours. Water (100 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (100 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 48c (2.46 g, yield: 100%). MS m / z (ESI): 579 [M+1]+ Step 3: 48c (2.46 g, 4.25 mmol) was added to a single-necked flask containing methanol (20 mL) and tetrahydrofuran (20 mL), p-toluenesulphonic acid (73.12 mg, 425.12 pmol) was added under nitrogen atmosphere, and the mixture was stirred at room temperature for 2 hours. The reaction was quenched by adding a saturated ammonium chloride solution (100 mL) to the reaction solution, and extracted with ethyl acetate (100 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 48d (1.9 g, yield: 90.4%). MS m / z (ESI): 495 [M+1]+ Step 4: 48d (2 g, 4.04 mmol) was dissolved in dichloromethane (20 mL), and the mixture was purged three times with nitrogen and cooled to 0°C. Triphenylphosphine (1.59 g, 6.07 mmol) and carbon tetrabromide (2.01 g, 6.07 mmol) were then added, and the system was reacted at 25°C for 2 hours. The reaction solution was distilled under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 48e (1.5 g, yield: 66.5%). MS m / z (ESI): 558 [M+1]+ Step 5: 48e (0.5 g, 896.97 pmol), 2-(trifluoromethyl)-5,8-dihydro-6H- pyrano[3,4-b]pyridin-5-amine (391.39 mg, 1.79 mmol), sodium iodide (269.09 mg, 1.79 mmol) and DIEA (352.50 mg, 2.73 mmol, 475.07 pL) were dissolved in acetonitrile (20 mL), and the mixture was purged three times with nitrogen. The reaction system was reacted at 80°C for 15 hours. The reaction solution was quenched with water, extracted with ethyl acetate (50 mL x 2), and washed with a saturated sodium chloride aqueous solution (50 mL x 2). The organic phase was dried over anhydrous sodium sulphate, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 48f (190 mg, yield: 30.5%). MS m / z (ESI): 695 [M+1]+ Step 6: 48f (0.19 g, 273.50 pmol) was dissolved in tetrahydrofuran (5 mL), water (5 mL) and methanol (5 mL), lithium hydroxide (45.95 mg, 1.09 mmol) was added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 25°C for 16 hours. The resulting reaction system was adjusted to pH 5-6 with 1 M dilute hydrochloric acid, extracted with ethyl acetate (50 mL x 3), and washed with a saturated sodium chloride aqueous solution (50 mL x 2). The organic phase was dried over anhydrous sodium sulphate, and the filtrate was concentrated under reduced pressure to obtain 48g (130 mg, yield: 69.8%). MS m / z (ESI): 681 [M+1]+ Step 7: 48g (65 mg, 95.49 pmol) and 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (54.43 mg, 143.24 pmol) were dissolved in N,N-dimethylformamide (5 mL), N,N-diisopropylethylamine (37.03 mg, 286.48 pmol, 49.90 pL) was added, and the reaction system was reacted at 25 °C for 48 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (80 mL x 3), washed with a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulphate, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography using eluent system A to obtain 48h (63.28 mg, 95.49 pmol, yield: 100%, crude), which was directly used in the next step. MS m / z (ESI): 663 [M+1]+ Step 8: 48h (63.28 mg, 95.49 pmol) was dissolved in trifluoroacetic acid (5 mL), and the reaction system was reacted at 90°C for 0.5 hours. The resulting reaction system was concentrated, and the residue was purified by silica gel column chromatography using eluent system A to obtain Example 48 (12 mg, yield: 24.5%). MS m / z (ESI): 513 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.32 (d, 1H), 8.94 (s, 1H), 8.37 - 8.11 (m, 3H), 7.89 (t, 1H), 7.48 (d, 1H), 5.70 (s, 1H), 5.01 - 4.71 (m, 3H), 4.55 - 4.11 (m, 3H), 3.84 - 3.56 (m, 4H), 2.05 - 1.28 (m, 4H). Example 62 (Z)-4-((2,4-Dimethoxybenzyl)amino)-13-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-10,11,12,13-tetrahydroazecino[4,3-g]imidazo[1,5-a]quinoxalin-14(9H)-one Step 1: 2-(Trifluoromethyl)-8H-pyrano[3,4-b]pyridin-5-one 62a (3 g, 13.82 mmol) and hydroxylamine hydrochloride (960 mg, 13.82 mmol) were dissolved in ethanol (30 mL) and sodium acetate (3.40 g, 41.45 mmol), and the mixture was purged three times with nitrogen. The system was reacted at 80°C for 1 hour. The resulting reaction system was cooled to room temperature, concentrated, quenched with water, extracted with ethyl acetate (100 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 62b (3.10 g, yield: 96.7%). MS m / z (ESI): 233 [M+1]+ Step 2: 62b (3.1 g, 13.35 mmol) and wet palladium on carbon (811 mg, 0.67 mmol, 10% purity) were dissolved in methanol (40 mL), and the mixture was purged three times with hydrogen, and reacted at 25°C under a hydrogen balloon for 4 hours. The resulting reaction system was filtered and concentrated to obtain 62c (2.80 g, crude). MS m / z (ESI): 219 [M+1]+ Step 3:   Methyl 7-bromo-4-((2,4-dimethoxybenzyl)amino)imidazo[1,5- a]quinoxaline-8-carboxylate 62d (1 g, 2.12 mmol) and cuprous iodide (81 mg, 0.42 mmol) were dissolved in N,N-dimethylformamide (11 mL) and triethylamine (11 mL), and the mixture was purged three times with nitrogen. Hex-5-yn-1-ol (1.04 g, 10.61 mmol) and bis(triphenylphosphine) palladium(II) dichloride (149 mg, 0.21 mmol) were added, and the resulting mixture was purged three times with nitrogen. The system was reacted at 40°C for 16 hours. The resulting reaction system was cooled to room temperature, concentrated, quenched with water, extracted with ethyl acetate (60 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated to obtain 62e (0.95 g, crude). MS m / z (ESI): 489 [M+1]+ Step 4: 62e (0.95 g, 1.94 mmol) and Raney nickel (100 mg) were dissolved in methanol (10 mL) and tetrahydrofuran, and the mixture was purged three times with hydrogen, and reacted at 25°C under a hydrogen balloon for 0.5 hours. The resulting reaction system was filtered and concentrated to obtain 62f (0.90 g, crude). MS m / z (ESI): 491 [M+1]+ Step 5: 62f (0.9 g, 1.83 mmol) was dissolved in dichloromethane (10 mL), and the mixture was purged three times with nitrogen and cooled to 0°C. Triphenylphosphine (962 mg, 3.67 mmol) and carbon tetrabromide (1.22g, 3.67 mmol) were then added, and the system was reacted at 25°C for 2 hours. The resulting reaction system was concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 62g (560 mg, yield: 55.2%). MS m / z (ESI): 553 [M+1]+ Step 6: 62g (1 g, 1.81 mmol), 2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-amine (788 mg, 3.61 mmol), and sodium iodide (541.67 mg, 3.61 mmol) were dissolved in acetonitrile (60 mL), N,N-diisopropylethylamine (1.40 g, 10.84 mmol, 1.89 mL) was added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 80°C for 15 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (80 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 62h (410 mg, yield: 32.9%). MS m / z (ESI): 691 [M+1]+ Step 7: 62h (430 mg, 0.62 mmol) was dissolved in tetrahydrofuran (5 mL), water (5 mL) and methanol (5 mL), lithium hydroxide (60 mg, 2.49 mmol) was added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 25°C for 16 hours. The resulting reaction system was adjusted to pH 5-6 with 1 M dilute hydrochloric acid, extracted with ethyl acetate (50 mL x 3), washed with a saturated sodium chloride aqueous solution (30 mL), dried over anhydrous sodium sulphate, filtered, and concentrated to obtain 62i (410 mg, crude). MS m / z (ESI): 677 [M+1]+ Step 8: 62i (56 mg, 83 pmol) and 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (62 mg, 0.17 mmol) were dissolved in N,N-dimethylformamide (10 mL), N,N-diisopropylethylamine (54 mg, 0.41 mmol, 72 pL) was added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 25°C for 48 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (80 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 62j (16 mg, yield: 29.4%). MS m / z (ESI): 659 [M+1]+ Step 9: 62j (5 mg, 7.6 pmol) was dissolved in trifluoroacetic acid (2 mL), and the mixture was purged three times with nitrogen. The reaction system was reacted at 90°C for 0.5 hours. The resulting reaction system was concentrated, and the residue was purified by silica gel column chromatography using eluent system A to obtain Example 62 (0.55 mg, yield: 14.2%). MS m / z (ESI): 509 [M+1]+ 1H NMR (400 MHz, MeOD) 8 9.07 (d, 1H), 8.27 (d, 1H), 8.18-8.06 (m, 1H), 7.99-7.92 (m, 1H), 7.79 (dd, 3.0 Hz, 1H), 7.25 (d, 1H), 6.65 (dd, 1H), 6.10-5.99 (m, 1H), 5.88-5.78 (m, 1H), 4.51 (dd, 1H), 4.34 (dd, 1H), 4.28-4.20 (m, 1H), 3.65-3.58 (m, 1H), 3.09-2.98 (m, 1H), 2.13 (s, 1H), 2.04-1.96 (m, 1H), 1.56 (s, 3H), 1.29 (s, 2H). Examples 62-P1 & 62-P2 Example 62 (55 mg, 4.24 mmol) was separated by chiral preparative HPLC to obtain     rel-(R,Z)-4-amino-13-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4- b]pyridin-5-yl)-10,11,12,13-tetrahydroazecino[4,3-g]imidazo[1,5-a]quinoxalin-14(9H)-one 62-P1  (18 mg, yield: 32.7%) and  rel-(S,Z)-4-amino-13-(2- (trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-10,11,12,13- tetrahydroazecino[4,3-g]imidazo[1,5-a]quinoxalin-14(9H)-one 62-P2 (20 mg, yield: 36.4%). 62-P1 (tR: 1.624 min): 1H NMR (400 MHz, MeOD) 5 9.06 (dd, 1H), 8.21 (dd, 1H), 8.08-7.91 (m, 2H), 7.78 (dd, 1H), 7.25 (dd, 1H), 6.65 (dd, 1H), 6.09-5.77 (m, 1H), 5.52-5.26 (m, 1H), 4.60 (s, 1H), 4.51 (dd, 1H), 4.23 (ddd, 1H), 3.62 (t, 1H), 3.04 (dt, 1H), 2.23-2.07 (m, 1H), 2.03-1.95 (m, 1H), 1.77 (q, 1H), 1.60 (dt, 1H), 1.45-1.20 (m, 3H). 62-P2 (tR: 1.410 min): 1H NMR (400 MHz, MeOD) 5 8.97 (d, 1H), 8.12 (dd, 1H), 7.98-7.82 (m, 2H), 7.69 (dd, 1H), 7.15 (d, 1H), 6.55 (dd, 1H), 6.00-5.69 (m, 1H), 5.42-5.16 (m, 1H), 4.42 (dd, 1H), 4.28-4.08 (m, 2H), 3.52 (t, 1H), 2.95 (dt, 1H), 2.12-1.97 (m, 1H), 1.93-1.84 (m, 1H), 1.71-1.61 (m, 1H), 1.46 (d, 1H), 1.371.05 (m, 3H). Example 63 4-Amino-13-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-8,9,10,11,12,13-hexahydroazecino[4,3-g]imidazo[1,5-a]quinoxalin-14(7H)-one MeO Step 1:   (Z)-4-((2,4-Dimethoxybenzyl)amino)-13-(2-(trifluoromethyl)-5,8- dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-10,11,12,13-tetrahydroazecino[4,3-g]imidazo[1,5-a]quinoxalin-14(9H)-one 63a (15 mg, 23 pmol) and platinum dioxide (3 mg, 12 pmol) were dissolved in methanol (3 mL), and the mixture was purged three times with hydrogen. The reaction system was reacted at 25°C under a hydrogen balloon for 1 hour. The resulting reaction system was filtered and concentrated to obtain 63b (12 mg, crude). Referring to the synthesis method described in Step 8 of Example 14, Example 63 (3 mg, yield: 32.4%) was obtained from 63b (12 mg, 18 pmol). MS m / z (ESI): 511 [M+1]+ The following examples were prepared by reference to Example 62: Example Structure MS m / z (ESI) [M+1]+ Example Structure MS m / z (ESI) [M+1]+ 64 H,N \ YN N \= /   xxY <Yy° YY OJy yx 485 177-P2 H2N 2 \ / ^N r \ j N N-^ a<r 471 65 H,N VYN )r \ j N YY   x\ / CF’ O_^k / Y ^ox 485 178 H2NW^o N^y^Y / \        cf3 W zY yy^° e \ o Lyn 459 66 H2N 2 \ / ^n / r\ j N 'Bw'" 495 179 H1NV^o y^ W yY o  n^n 473 67 H,N ~ 2 \Z^N / r\ j N By ^<Y 495 180 H2NV^^o / \ W yY YYyf o          N 473 68 H2N N   N / A \= / o^yyr 497 181 H2Vn n^nx /   \         CF, W yY yY_° o     I\-Y"~N 471 69 H2N 2 yZ^N H I] N N^ r / 0 J_ ^N / =\ W\ / / ^cf3 \ / N o-^ 509 182 H,N \ Yn / yY W yY yY.° / y 485 70 h2n \   / / N / r \ J N (   / —N   7=\ i yA 11 509 183 / , n K OF / O / Z~z / / ^% z _J 485 71 H,N    ~ t \ JJ N rF / A o^% / =\ W\ / ^cf3 \ / N 511 184 H,N V /  \         CF, w o   nF^n 473 72 H2N    ~ \ Fn / r\ j N 1F )=o 1    n / =\ Vf FCFJ \ / N o— / 511 184-P1 H2X\ Ao / \        cf3 W / W o    n~F^n 473 73 H,N \ F~N F\ J N pF / A O'-'7 >o 511 184-P2 H,N A /  \         CF3 W / W O    N-.Z"N 473 74 H,N \ F^ \ J N fF <w o-^>o \f / ycr3 \ / n o- / 527 185 HzN\ Fn N <J'^' 467 75 H,N FA JJ N o^O 1            z=\ A W\ / FCF3 \ / N 511 186 H2NV^o /  \        CF3 W / W . / AF’ \ 2 '''f     N^ / N 469 76 H,N    ~ 2 N t \ J N )=o / =\ W\ / Xcf3 \ / N O— / 513 187 "2NW-n n\Z / x / \         cf3 W / T< , / \XO \ 7 481 77 h2n \   / 7 N 4 \ J N 1-- / ° / / =\ / Xcf3 N—J 457 188 H2N\ X"\ X \ JJ N M' 457 78 & / rS XX^ 513 189 H2V / ^o /  \        CF3 W 459 79 H,N \ X° Nyy^ y) r / ° o^Nv / =\ / \\ / / CF’ \ / N 501 190 H?N \ < N /  \        CF, W H 471 80 H2N / =\ n 7—J XX \ / ° O^\ / =\ AX\ / ^CF3 \ / N 510 191 H2vK /  \        CF3 W (    N^Z N 473 81 H2\^n / =° / / / =\ ftA ^CF3 \ / N o— / 509 192 h2n j N N-^ A / .'" °y^ 471 82 yy ,== / / =° 1           r=\ / / CF3 \ / N 497 193 H,N \ r \ j N ft- 471 83 H2N    / =\ H^n n 2— / fto 1           z=\ / A / / CF3 \ / N 506 194 H2W / > / \ CF1 W / ft (    N— / N °'y / 473 84 "2V / ^N yjwx r / ° /           z=\ h\\ / / cf3 \ / N o—' 511 195 H2NW^o Nyy^ /  \         CF3 W / ft 473 85 N\ y^ yy r / ° 1 / =\ ft\\ / ^CF-’ \ / N 499 196 u z k II z'ft ' xaz-s 485 86 h2n / =\ H / n N p-- / yy r / ° /    N / =\ / ^cf3 \ / n 508 197 H2Vv^ /  \        CF3 W zftft <^V° \ 7 485 87 H,N n\Z / x >o / / =\ W\ / / CF’ \ / N o— / 513 198 h2n )r \ j N l\     CF3 W zW f n- / ~n 455 88 H2NV^o >o 1 z— N    / =\ X\\ / / ^CF-’ \ / N O— / 501 199 H2V^o /  \         zCF3 W zi f     N~~Z N 457 89 H2N   z=\ N  2—J o^>o 1           z=\ / / CF3 \ / N 510 200 H2W^ N^jV-N^ /  \        CF3 W zW f n^~n 469 90 £ / (S z-z      o xKXa Z Z   Z \ « 527 201 H1NvJ^o W H f N^ / N 471 91 \— / >O / --\   / / CF3 \ / N 515 202 H2\    n r \ j N sf5 W zZZf f L7"n 513 92 H2N    / =\ h^n N  \—J \_— /  )=O 0^ / ^^ / =^ AA\ / / ^CF3 \ / N ()— / 524 203 H2N\ / ^n H ji N 511 93 o o-^G0 1    / - N / =^ XA ^CF* \ / N 527 204 H2NW^o /   \          SFs w f n^>n 515 94 "^o M 0- / =0 1            / =\ X\\ GCF-’ \ / N 0= 515 205 "2W'<» /   \          SFs W N~~ / N 513 95 H2N / =\ Hu o W / ^CF3 \ / N O'7 524 206 s GC / 0 z~z u •51 Ul 527 96 h’Vn gja o \y )=o 1 r~ N / = °^ / W\ / / ^¾ \ / N o— / 540 207 H,N \ < N Nfy /  \         SF, W zW 525 97 H2Nv / -o / y / =° ®     W\ / ^CF3 \ / N 528 208 H,N    ~ 2 VG^N H j N N — SF5 ( x-G 512 98 H2N    / =\ Hg N 2—J y} XN^ >O yy / ^cf3 ( / n 537 209 H,N VG^N G \ j N SF, GG GG GG^° / C     N— / 7 510 99 hA / ^n yj-A r / ° /    N / =\ o^N Ay ^cf3 ' \ / N () / 540 210 "2NV^o /  \         SF5 W 514 100 "2NW<> yy r / ° \ / =\ Xa\ / / ^CF3 \ / N o— / 528 211 H2V / ^o Nw^ /   \          SF5 W 512 101 H2N / =\ Kj N 2— yy r—   )^° 1 / —N / =\ 0 * W\ / bCF3 \ / N o^7 537 212 HA / ^n Nvl / \ /  \          SFs W A (     N-- / ’ 526 102 H2V / *n nqa o / ° Ay r~ N / =\ X"\\ ^CF-3 \ / N o— / 523 213 H2Vv^n yv< /  \         SF, W A yjp^ 524 103 “2NV^o yy <3        / =\ XX\ / ^CF3 \ / N 511 214 H,N N O 514 104 H2N / =\ N p—7 yy — / >0 <y / —n / =\ hX\ / / CF3 \ / N () / 520 215 H,N \ < ° y / W A 516 105 o r / 0 / / = v7 W\ / ^cf3 \ / ^N 537 216 H2N\ / ^n nQA /  \         SF5 W zW O    N^ / 528 106 H2NvV-o y} r / 0 I         / = V7 W\ / hCF3 \ / N 525 217 "2\ z^Q l \           SF, W zW f^V° \ 7 O    N— 530 107 H2N / =\ Hy N 2—J o r / 0 \ / =\ M\ / / CF^ \ / N 0 7 534 218 H2N    z^ 2 \ z^ N / r\ j N N^ 445 108 H,N 2 \ZN 4 \ JJ N r / ° / O-N   z=\ X\\ / / CF3 \ / N o— / 499 219 ,l2W'» W / —\ ^o r \\ '' / r Z / N q^^n-^ 447 109 H2V^° r / ° [ O-N / =\ / / CF’ \ / N O^ 501 220 n ® cz / 0 / -2 1 459 110 H2N   z=\ H^n n 2— ( O-N   z=\ b\\ / / CF’ \ / N o— / 510 221 H2vK W / —x ^o c \\ 11 / r Z / N 461 111 H,N    z. \ / / n H J N N"^ N 538 222 H,N J N N-^ 3^” 443 112 NyyJ W \ / ° Az N 540 223 H2NV / -o / —\ (7 \\ 11 !     v V_ / N (     N— 445 113 H2N   7=\ Hz N 2—' M \ / 0 N 549 224 "2W:;^ / j-A W z~<s> / r V- / N (     N— 457 114 H,N \ A N t \ J N N^ r / ° N 537 225 H,N \ J N N"^ C Z zr-N^y-'^ rz°p=N O    N~V 496 115 / \               w <X A    ,2^ ,2 zZXx. AA ° A I J 2^ O J? 539 226 Ny^Z O z-N^rCF3 <Y°O=N 0   N— / ~^ 498 116 H2N / =\ H? N \>----7 r / ° hah 548 227 H2W*n Zj-A O <Y°O=n 510 117 h2n N N*^ r / ° F (  = N    / = /    .    F X\\ / / N\ / ( y N      F o / 550 228 H2\X t / O z / -N^y-CF3 o     N-~y 512 118 H,N t \ J N o 7=0 cf2h /            / = /    „     F W\ / / ^ / ^( <\ HN         F 582 229 H,N    z^ \ Z^N J N   N-^ O z^N^rCF3 (J^r 494 119 H2N    ~ \ Z^N Z\ JJ N yy / =° F 1 s— N ,= /    / --\ F - / \ o— / 578 230 HzN=V-o t / O / T-N'^VCF’ ’ -• - 496 120 h2n \ / z N t \ J N !>. yy =Z 7=0 cf2h / ^N / = / / —\ F W\ / / Nx W ( yN x— / f o= 610 231 yV\ O ( N— / 508 121 = / ‘ 580 232 H,N \ Zx jj N O    N— / 496 122 H2N    z^ \ / ^N / r\ J N N-^ yy ^- / >o cf2h / v / / \ T^N x-- / F 612 233 H2NW-o n / -Z n r M=orv /       i         / N 498 123 H,N    z^ \ Z^N \ J N N-^ 7=0 = /  =N  z=\ W\ / ^CF3 ( / N o^ / 525 234 fat? A ,z~z ' JcO 510 124 H,N    ~ \ / N J N p" ^yycr> 525 235 n  r / v           n O    N— 512 125 H,N    ~ 2 \   / ^N Ya J N 525 236 h2n J N k r /     r V_ / N 494 126 H,N    ~ V^N / M j N   N"^ y) yo -- / / =\ W\ yc^ \ / n 527 237 a ( jOCX V         \    / / o         o y 496 127 H,N N O   !— N   r=\ W\ / / CF3 \ / N ()— / 527 238 H1Nw^ n^n n r / r V- / N (    N— 508 128 H,N ji N N^ M. / — N    / =x W\ / Mf, \ / N ()- / 541 239 H2N 2 \ Z^N )r\ j N   N*^ w / \ / >O f \\ y~~CF-> / \ ' O 507 129 h2n Z^N / r\ ji N °\ / \ hn-“ y° <f ,—N / =\ W\ / / CF’ \ / N o— / 526 240 1-x^<> NwJ W / \ / .O \  \\ ' / -CF, 509 130 £ , (S z-z    o yk H 527 241 H2vH Hr0 €>n CF3 523 131 H2NV^o / — / / ° O   = N   z=\ W\ / A \ / N O / 515 242 u - Z-z     0 / .......... 521 132 H2N   7=\ H^n N 'j)—y / - / ° O / ^N   / =\ A\ / ^cf3 \ / N O— / 523 243 H,N \ An H \ j N lA W / \ / O / \\ ACF, /    \ A / N (       N—- 505 133 HAx AjA / = / >° /  ,— N / =\ A\ V CF3 \ / N 523 244 W AH f v z~cf3 /    \ k / N (     N— / 507 134 "A / . / v / = / >° / / =\ / / CF3 \ / N o—' 511 245 “A" / jA W zAH / A ,o f \\ A-cf3 /     \ A / N (     N— / 519 135 H2N    / =\ N  2—z / =A >o /         f=\ W\ / HCF3 \ / N 520 246 K czx < O M n 441 136 u / z-z      o c JLA A / O 1XXX z z    > > X      [J 525 247 s Q / € n 445 137 H2V^o n^Jv^ / — / =° /   ,—N   z=\ \ / N 513 248 H,N    ~ N^V’V / ^zCF3 ir° O _ZNV^N 457 138 H2N / =^ H^N N 2— / o / — / ° /   ,— N / =\ M\ / / CF3 \ / N 522 249 - ' a 459 139 u / (k z-z     o T > 527 250 h2n \ / r \ j N N-^ Y fl         xf3 'x___ 441 140 H1V^o o )=o /   ,—N   z=\ M\ / ^CF, \ / N 515 251 a / --\     .z, ^.2 ( XXX 0      '-o Q n jq 443 141 H2N / =\ Hx N O /   r- N   z=\ W\ V CF3 \ / N 524 252 t1 u r VjZ z-zZ o \ z XI j a 455 142 H2N XN ■X J N Vo / O-N / =\ W\ / XCF3 \ / N 513 253 H2N r \ j N \ /         / SFs ir°rr 499 143 / —' X° / O-N   z=\ V^' H\ / XCF3 \ / N O~' 515 254 in JZ1 / Z a 503 144 H2N   z=\ Hx / -- / =° / O-N / =\ xx XCF3 \ / N 524 255 a o___ FJ XX \ ° / z~z yx z / cz 'ji 515 145 H,N    ~ \ ^~N J N N"^ >■ 552 256 xl a 517 146 H2NW^o NvV^ w N 554 257 H,N ~ -X j N Xr 499 147 H2N / =\ n O w ()— N 563 258 ir> <Z3 °~\ / 4          z z         __ / CM s 501 148 H,N    ~ H j N w* V° VHN-N / =\ CF, N 551 259 s /        2  2 o ”5 UI 513 149 H^o w / —  )=° ( HN-N / =\ N 553 260 H,N \      N j N   N-^ ■ -¾ •..... 499 150 H2N / =\ H^n N 2—J o / —   / =0 < HN-N / =,    rr w N 562 261 H,N 2 t \ J N W' 515 151 H2N )r\ j N N-^ ... V^Nv / =V ^= / / 4 ^V=< \ / 51 F 564 262 "2V'o I \          CF, W H fYt°Wn v-() 515 152 H2N \       N r \ j N yy z— / yo cf2h \ / \ F / 4 rvK \ / N F 596 263 H2V / ^n nQ-A /  \         CF, fyy°O C N.yy 527 153 H2N \ 4 \ JI N O / - /  >0 F (          / =( / \   F ( / ~N    x '    F o—' 592 264 H2N 2^4 ji N   N-^ b..... F F   <( / 517 154 HjN    ~ \ / / > )r\ j N « / --' lo cf2h V- N X--F C>—'' 624 265 H,N 4 \ J N N-^ F           ° 533 155 h2n z^ 2 \ ^N / V y / / - / 4o F ( / —N / =( / > F ° —' \--4 J— N )=( ( HN X / F o— 594 266 "!W<> nJJ"I /  \         CF, (i^ lb ( / F N« / A F           ° 533 156 H!V^n / V w / - /  lo CF,H (   / -N   / =( / --\  F °—'  }-- / J— N  1=( (  Kn X-- /   F 626 267 H2NW-n n\Z / x /  \        CF3 W Zt°1 / n Ij F F           ° 545 157 H2N    ~ 4 \ J N bb J0 L^n z=\ b\\ 4cf3 \ / n o— / 495 268-P1 H,N    ~ \    / / N / A J N N"^ bb o-^>o \ bb^CF, o 484 160 H2N \ , / ^N J N 14 r / ° /    N / =\ ^IX / XCF3 N— 457 269 HzN / ^o / Y° H O \—O 486 161 f / A o L / —N o 482 270 H2NW^n NvV o<? 498 162 H2N \ Z^N t \ J N   N r     / ° /   / — N    / =\ ()— / 496 270-P1 £ u J z-zz O I XC) 498 163 "!Vo y} r / 0 W\ / / cF3 ( / N 0- / 499 270-P2 HA / ^n n\Z / x \ /   ^S^ / CF3 / Y° O O \—O 498 164-P1 h2n y—n Z''£'" 480 271 wc f o      ^-o n 500 165-P1 h2n n y XF3 fr0£X 497 272 H,N \ / A N Aa j N o^””^=o ^C / sf> 542 166 A 482 273 H2\^o o^>o \ JL^AsF, o 544 167 z-4 / yY0 * z-\==\     1 494 274 px F O    zz-2 Z1 <z> 556 168 h2n n I / cf3 fr°fJ ""() 496 275 J yZZ £=<> Jr 558 169 H2NW^o /  \        CF, W zi / y° \ / (   N^Y\ voz 498 276 H2N \ / Z N Z \ J N N^ w 1—     / ° o^\y^ \ ££"cf-, 0 484 170 h2n Z'Z^'O Z yo yxf V O 484 277 & o-a r Z-Z B 486 171 H,N \ ZN JJ N / \     CF, W zY AA, ° Z \\ f U"n 455 278 H2Vn Nvy Z Z    ^X\ / ('F3 <Y° ZT N^ / Z^ o^Z Vo 498 172 HV« £ /  \         CF3 W zY Z\z \ ? f   N-V~N 457 279 & Z? O-A O I ZcO z z V_z-s 500 173 HATo Nyz^ /   \         CF3 W ZAZ \ / 455 280 H,N \   / Z N z  \ JI N   N-^ r     / ° o^N\yy o 542 174 o kJ / z-zZ    Q / \      V—z JjQ ) z z — \  > M          —-- / s: 469 281 H2N\ / -o N^y-^ M r / ° ^U-SFS 544 175 s Zpz\zyP v Laa 2p    \ V A " n 467 282 H,N X / 'N Ny^\ \ /    ^\ / SF5 <yo nr o—A Vo 556 176 H,N    ~ X      N / r \ j N / \     CF, W / y° \ / o   n~V^n 457 283 5 pc ° '^1 558 177-P1 N / X      CF, W zY 471 Alternatively, Examples 65, 77, and 157 were prepared using the following method: Example 65 4-Amino-11-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)- 5     10,11-dihydro-7H-imidazo[1,5-a][1,4]oxazino[7,6-g]quinoxalin-12(9H)-one Step      1:     A     solution     of     methyl 7-bromo-4-[(3,4- dimethoxyphenyl)methylamino]imidazo[1,5-a]quinoxaline-8-carboxylate 65a (600 mg,      1.27      mmol),      potassium      trifluoro(2-tetrahydropyran-2- yloxyethoxymethyl)borate (677 mg, 2.55 mmol), caesium carbonate (827 mg, 2.55 mmol), and CataCxiumA-Pd-G3 (93 mg, 0.13 mmol) in 1,4-dioxane (15 mL) and water (3 mL) was purged with nitrogen, sealed in a microwave vial, and stirred under microwave irradiation at 110°C for 2.5 hours. The reaction solution was filtered to remove solids, and the filtrate was diluted with ethyl acetate (250 mL), and washed with water and a sodium chloride aqueous solution. The organic phase was concentrated, and the residue was purified by silica gel column chromatography to obtain 65c (210 mg, yield: 35.6%) as a pale yellow oily liquid. MS m / z (ESI): 467 [M+1]+ Referring to the synthesis method of Example 62, Example 65 (22 mg, yield: 3.7%) was obtained from 65c (620 mg, 1.33 mmol). MS m / z (ESI): 485 [M+1]+ 1H NMR (400 MHz, MeOD) 6 9.28 (d, 1H), 8.40 (m, 2H), 8.07, 7.78 (d, 1H), 7.75 (m, 1H), 7.44 (m, 1H), 6.03,5.83 (s, 1H), 5.00 (m, 2H), 4.78 (m, 2H), 4.42 (m, 1H), 4.18 (m, 2H), 3.95 (m, 1H), 3.70 (d, 1H), 3.42 (m, 1H), 3.14 (m, 1H). Example 77 4-Amino-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-5a,7,8,9,10,11,12,14a- octahydro-13H-azonino[4,3-g]imidazo[1,5-a]quinoxalin-13-one 77 Referring to the synthesis method described in Step 1 to Step 2 of Example 63, Example 77 (6 mg, yield: 13.3%) was obtained from (Z)-4-((3,5-dimethoxybenzyl)amino)-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-9,10,11,12-tetrahydro-13H-azonino[4,3-g]imidazo[1,5-a]quinoxalin-13-one 77a (60 mg, 4.24 mmol). MS m / z (ESI): 455 [M+1]+ Example 157 (Z)-4-Amino-11-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5- yl)-10,11-dihydroazocino[4,3-g]imidazo[1,5-a]quinoxalin-12(9H)-one Referring to the method described in Step 3 to Step 9 of Example 62, Example 5   157   (22 mg, yield:   1.1%) was obtained from 7-bromo-4-((3,4- dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 62d (2 g, 4.25 mmol). MS m / z (ESI): 481 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 8 9.18 (d, 1H), 8.22 (s, 1H), 8.15 - 8.05 (m, 1H), 8.01 - 7.89 (m, 1H), 7.84 (dd, 1H), 7.62 (s, 2H), 7.18 (d, 1H), 6.59 (ddd, 1H), 10   5.93 (m, 1H), 5.55 (d, 1H), 4.94 - 4.74 (m, 2H), 4.34 - 4.12 (m, 2H), 3.76 (dd, 2H), 3.16 (d, 1H), 2.76 (td, 1H). Example 158 (Z)-4-Amino-12-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5- yl)-9,10,11,12-tetrahydro-13H-azonino[4,3-g]imidazo[1,5-a]quinoxalin-13-one 15 o I58d Referring to the synthesis method described in Step 3 to Step 9 of Example 62, Example 158 (23 mg, yield: 1.1%) was obtained from methyl 7-bromo-4-((2,4- dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 158a (2 g, 4.24 mmol). MS m / z (ESI): 495 [M+1]+ 1H NMR (400 MHz, MeOD) 5 9.05 (s, 1H), 8.19-8.08 (m, 2H), 7.95 (s, 1H), 7.78 (dd, 1H), 7.31 (d, 1H), 6.63 (dd, , 1H), 6.28-5.93 (m, 1H), 5.53 (d, 1H), 4.43 (dd, 1H), 4.34-4.16 (m, 2H), 3.97-3.69 (m, 1H), 3.42 (d, 1H), 2.26-1.87 (m, 3H), 1.54-1.26 (m, 2H). Examples 158-P1 & 158-P2 158                              158-P1                      158-P2 Example 158 (140 mg, 0.28 mmol) was separated by chiral preparative HPLC to obtain (R,  Z)-4-amino-12-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4- b]pyridin-5-yl)-9,10,11,12-tetrahydro-13H-aza[4,3-g]imidazo[1,5-a]quinoxalin-13-one 158-P1 (46 mg, yield: 32.9%) and rel-(R, Z)-4-amino-12-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-9,10,11,12-tetrahydro-13H-aza[4,3-g]imidazo[1,5-a]quinoxalin-13-one 158-P2 (45 mg, yield: 32.1%). 158-P1 (tR: 1.733 min): 1H NMR (400 MHz, MeOD) 5 9.05 (s, 1H), 8.19-8.07 (m, 2H), 7.93 (s, 1H), 7.78 (d, 1H), 7.30 (s, 1H), 6.63 (dd, 1H), 6.10 (dq, 1H), 5.53 (d, 1H), 4.37 (ddd, 1H), 4.22 (ddd, 1H), 3.92 (d, 1H), 3.72-3.60 (m, 1H), 3.42 (d, 1H), 2.21 (dd, 1H), 2.12-1.88 (m, 2H), 1.53-1.26 (m, 2H). 158-P2 (tR: 0.771 min): 1H NMR (400 MHz, MeOD) 5 9.04 (d, 1H), 8.20-8.08 (m, 2H), 7.93 (d, 1H), 7.78 (d, 1H), 7.30 (s, 1H), 6.63 (dd, 1H), 6.31-5.90 (m, 1H), 5.53 (d, 1H), 4.37 (ddd, 1H), 4.22 (ddd, 1H), 3.92 (d, 1H), 3.66 (t, 1H), 3.42 (d, 1H), 2.21 (dd, 1H), 2.13-1.86 (m, 2H), 1.53-1.26 (m, 2H). Example 159 4-Amino-12-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-7,8,9,10,11,12-hexahydro-13H-azonino[4,3-g]imidazo[1,5-a]quinoxalin-13-one Referring to the synthesis method described in Step 1 to Step 2 of Example 63, Example 159  (15 mg, yield: 17.7%) was obtained from (Z)-4-((3,5- dimethoxybenzyl)amino)-12-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-9,10,11,12-tetrahydro-13H-azonino[4,3-g]imidazo[1,5-a]quinoxalin-13-one 159a (110 mg, 4.24 mmol). MS m / z (ESI): 497 [M+1]+ 1H NMR (400 MHz, MeOD) 5 9.06 (d, 1H), 8.25-8.10 (m, 2H), 7.96 (d, 1H), 7.80 (dd, 1H), 7.42 (d, 1H), 6.05 (s, 1H), 4.40-4.22 (m, 2H), 3.94-3.84 (m, 1H), 3.20 (dd, 1H), 3.00 (dd, 1H), 2.84-2.73 (m, 1H), 2.58 (ddd, 1H), 1.98 (d, 2H), 1.811.59 (m, 2H), 1.50 (s, 1H), 1.27-1.19 (m, 1H), 1.07 (dd, 1H). Alternatively, Examples 164, 165, and 167 were prepared by reference to the following method: Example 164 (Z)-4-Amino-12-(6-(trifluoromethyl)-2,3-dihydrobenzofuran-3-yl)-9,10,11,12-tetrahydro-13H-azo[4,3-g]imidazo[1,5-a]quinoxalin-13-one Step 1: 6-(Trifluoromethyl)benzofuran-3-one 164a (2 g, 9.89 mmol) was dissolved in methanol (10 mL), and the mixture was purged three times with nitrogen. Sodium borohydride (449 mg, 11.87 mmol) was added, and the resulting mixture was reacted at 25°C for 1 hour. The resulting reaction system was quenched with a saturated sodium bicarbonate aqueous solution, and extracted with ethyl acetate (80 mL x 3). The organic phases were combined, washed with a saturated sodium chloride aqueous solution (30 mL), dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 164b (16 mg, yield: 89.1%). MS m / z (ESI): 205 [M+1]+ Step 2: 164b (0.15 g, 0.73 mmol) was dissolved in tetrahydrofuran (5 mL), and the mixture was purged three times with nitrogen and cooled to 0°C. Diphenylphosphoryl azide (214 mg, 0.88 mmol, 168 pL) and 1,8-diazabicyclo[5,4,0]undec-7-ene (134 mg, 0.88 mmol, 132 pL) were added, and the resulting mixture was stirred and reacted at 25°C for 16 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (50 mL x 3), washed with a saturated sodium chloride aqueous solution (30 mL), dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 164c (130 mg, yield: 77.2%). MS m / z (ESI): 230 [M+1]+ Step 3: 164c (0.13 g, 567.29 pmol) and triphenylphosphine (446 mg, 1.70 mmol) were dissolved in water (0.1 mL) and tetrahydrofuran (10 mL), and the mixture was purged three times with nitrogen, and reacted at 50°C for 15 hours. The reaction system was cooled to room temperature, and 0.5 M hydrochloric acid (30 mL) was added. The mixture was extracted three times with ethyl acetate (30 mL x 3), and the aqueous phase was subjected to rotary evaporation to dryness to obtain 164d (60 mg, yield: 52.2%). Referring to the synthesis method described in Step 6 to Step 9 of Example 62, Example 164 (23 mg, yield: 5.2%) was obtained from methyl (Z)-7-(5-bromopent-1-en-1-yl)-4-(2,4-dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 164e (500 mg, 0.93 mmol). MS m / z (ESI): 480 [M+1]+ 1H NMR (400 MHz, DMSO-d6) S 9.04 (s, 1H), 8.08 (d, 1H), 7.86 (s, 1H), 7.587.37 (m, 3H), 7.24 (t, 1H), 7.18-7.05 (m, 2H), 6.45 (dd, 1H), 6.11-5.75 (m, 2H), 4.84-4.72 (m, 1H), 2.04 (s, 1H), 1.92 (s, 1H), 1.69 (d, 1H), 1.37 (d, 1H), 1.22 (s, 1H), 1.08 (s, 1H). Step 8: Example 164 (50 mg, 0.10 mmol) was separated by chiral preparative HPLC to obtain rel-(R, Z)-4-amino-12-(6-(trifluoromethyl)-2,3-dihydrobenzofuran-3-yl)-9,10,11,12-tetrahydro-13H-azo[4,3-g]imidazo[1,5-a]quinoxalin-13-one 164-P1(18 mg, yield: 36.0%, MS m / z (ESI): 480 [M+1]+) and rel-(R, Z)-4-amino-12-(6-(trifluoromethyl)-2,3-dihydrobenzofuran-3-yl)-9,10,11,12-tetrahydro-13H-azo[4,3- g]imidazo[1,5-a]quinoxalin-13-one 164-P2 (20 mg, yield: 40.0%, MS m / z (ESI): 480 [M+1]+). 164-P1 (tR: 3.213 min): 1H NMR (400 MHz, MeOD) 5 9.01 (s, 1H), 8.09 (d, 1H), 7.93 (d, 1H), 7.59 (t, 1H), 7.33-7.25 (m, 2H), 7.11 (d, 1H), 6.65-6.56 (m, 1H), 6.18 (d, 1H), 6.06-5.92 (m, 1H), 4.81-4.71 (m, 2H), 3.57 (s, 2H), 2.17 (s, 2H), 1.28 (s, 2H). 164-P2 (tR: 3.006 min): 1H NMR (400 MHz, MeOD) 5 9.01 (s, 1H), 8.09 (d1H), 7.93 (d, 1H), 7.62-7.56 (m, 1H), 7.32-7.24 (m, 2H), 7.12 (d, 1H), 6.64-6.57 (m, 1H), 6.19 (s, 1H), 6.01 (d, 2H), 4.81-4.72 (m, 2H), 3.56 (d, 2H), 2.17 (s, 2H), 1.28 (s, 2H). Example 165 (Z)-4-Amino-12-(2-trifluoromethyl-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5- yl)-1,3,9,10,11,12-hexahydro-13H-azo[3,4-g]furo[3,4-c]quinolin-13-one Step 1: Methyl acetoacetate (82.88 g, 713.80 mmol) was dissolved in glacial acetic acid (1 L), 4-ethoxy-1,1,1-trifluoro-3-buten-2-one 165a (100 g, 594.84 mmol) and ammonium acetate (183.40 g, 2.38 mol) were sequentially added, and the mixture was stirred at 120°C for 16 hours. The resulting reaction system was cooled to room temperature, subjected to rotary evaporation to dryness to remove acetic acid, quenched with water, extracted with ethyl acetate (2 L x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 165b (80 g, yield: 61.3%). MS m / z (ESI): 220 [M+1]+ Step 2: 165b (80.5 g, 367.31 mmol) was dissolved in carbon tetrachloride (800 mL), N-bromosuccinimide (130.75 g, 734.62 mmol) and azobisisobutyronitrile (12.06 g, 73.46 mmol) were added under nitrogen atmosphere, and the mixture was stirred at 77°C for 16 hours. Upon completion of the reaction, the reaction system was subjected to rotary evaporation to dryness to remove the solvent, to obtain 165c (crude, 80 g), which was used directly in the next step. MS m / z (ESI): 376 [M+1]+ Step 3: 165c (80 g, 365.03 mmol) was dissolved in tetrahydrofuran (800 mL), diethyl phosphite (30.25 g, 219.02 mmol) and N,N-diisopropylethylamine (28.31 g, 219.02 mmol, 38.15 mL) were added, and the system was reacted at 25°C for 2 hours. Upon completion of the reaction, the reaction system was subjected to rotary evaporation to dryness, and the residue was purified by silica gel column chromatography using eluent system A to obtain 165d (80 g, yield: 73.5%). MS m / z (ESI): 298 [M+1]+ Step 4: Sodium hydride (71.66 g, 1.79 mol) was added to a three-necked flask, followed by the addition of tetrahydrofuran (solvent, 1.7 L) and methyl glycolate (64.55 g, 716.64 mmol) in an ice bath under nitrogen atmosphere, and the mixture was stirred for half an hour. 165d (178 g, 597.20 mmol) was then added to the system, and the reaction system was reacted at 25°C for 16 hours. Upon completion of the reaction, the reaction system was quenched with water, extracted with ethyl acetate (2 L x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated to obtain 165e (crude, 187 g). MS m / z (ESI): 276 [M+1]+ Step 5: 165e (187 g, 679.55 mmol) was dissolved in a mixed solvent of concentrated hydrochloric acid (500 mL) and 1,4-dioxane (500 mL), and the reaction system was reacted at 110°C for 0.5 hours. Upon completion of the reaction, the reaction system was subjected to rotary evaporation to dryness to remove the solvent, adjusted to pH 8 with a saturated sodium bicarbonate solution, extracted with ethyl acetate (2 L x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 165f (37.9 g, yield: 25.6%). MS m / z (ESI): 218 [M+1]+ Step 6: 2-(Trifluoromethyl)-8H-pyrano[3,4-b]pyridin-5-one 165f (21 g, 96.74 mmol) and hydroxylamine hydrochloride (6.72 g, 96.74 mmol) were dissolved in ethanol (210 mL) and sodium acetate (23.80 g, 290.15 mmol), and the mixture was purged three times with nitrogen. The system was reacted at 80°C for 1 hour. The resulting reaction system was cooled to room temperature, concentrated, quenched with water, extracted with ethyl acetate (500 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 165g (21.70 g, yield: 96.7%). MS m / z (ESI): 233 [M+1]+ Step 7: 165g (20.98 g, 90.37 mmol), zinc powder (59.08 g, 903.69 mmol) and ammonium chloride (48.34 g, 903.69 mmol) were dissolved in ethanol (40 mL), and the mixture was reacted at 50°C for 4 hours. The resulting reaction system was filtered, concentrated, and slurried with dichloromethane, to obtain 165h (12.6 g, yield: 63.9%). MS m / z (ESI): 219 [M+1]+ Step 8: Methyl 4-amino-5-bromo-2-chlorobenzoate 165i (80 g, 302.45 mmol), bis(pinacolato)diboron      (115.21      g,      453.68      mmol),      1,1'- bis(diphenylphosphino)ferrocene (16.77 g, 30.25 mmol), potassium acetate (59.37 g, 604.91 mmol), and palladium acetate (3.40 g, 15.12 mmol) were added to 1,4-dioxane (800 mL), and the mixture was purged three times with nitrogen. The reaction system was stirred at 80°C for 16 hours. The reaction solution was cooled to room temperature, and filtered to remove insoluble materials. The filtrate was concentrated, and the residue was purified by silica gel column chromatography using eluent system B to obtain 165j (84 g, 269.60 mmol, yield: 89.1%). MS m / z (ESI): 312 [M+1]+ Step 9: 165j (70.5 g, 226.27 mmol) was added to ethanol (1000 mL) and water (200 mL), followed by methyl 4-(((trifluoromethyl)sulphonyl)oxy)-2,5-dihydrofuran-3-carboxylate (62.49 g, 226.27 mmol), sodium carbonate (47.97 g, 452.55 mmol) and bis(triphenylphosphine)palladium(II) dichloride (15.88 g, 22.63 mmol), and the mixture was purged three times with nitrogen. The reaction system was reacted at 80°C for 4 hours. The reaction solution was directly concentrated, water was added, and the mixture was stirred for 10 min. The resulting system was filtered by suction, and the solid was slurried with ethyl acetate, to obtain 165k (49 g, 175.20 mmol, yield: 77.4%). MS m / z (ESI): 280 [M+1]+ Step 10: 165k (56.7 g, 202.74 mmol) was dissolved in dimethyl sulphoxide (25.23 mL), and 2,4-dimethoxybenzylamine (40.68 g, 243.28 mmol) and 1,8-diazabicyclo[5.4.0]undec-7-ene (92.59 g, 608.21 mmol, 90.78 mL) were added, followed by a BOP reagent (269.00 g, 608.21 mmol). The reaction system was reacted at room temperature for 1 hour. The reaction solution was added to ice water, and extracted with ethyl acetate. The organic phase was dried, concentrated, and slurried with methanol to obtain 165l (43 g, 100.26 mmol, yield: 49.5%). MS m / z (ESI): 429 [M+1]+ Step 11: 165l (5 g, 11.66 mmol) was dissolved in N,N-dimethylformamide (50 mL) and placed in a sealed tube. 2-(4-Pentynyloxy)tetrahydro-2H-pyran (2.94 g, 17.49 mmol), caesium carbonate (7.60 g, 23.32 mmol), dichlorobis(tricyclohexylphosphine)palladium(II) (860.62 mg, 1.17 mmol), and 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (1.11 g, 2.33 mmol) were added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 100°C for 2 hours. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate, washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 165m (6.05 g, 10.79 mmol, yield: 92.6%). MS m / z (ESI): 561 [M+1]+ Step 12: 165m (6.05 g, 10.79 mmol) was dissolved in methanol (60 mL), trifluoroacetic acid (12 mL) was added, and the reaction system was reacted at room temperature for 1 hour. The reaction solution was adjusted to pH=8-9 with a sodium bicarbonate aqueous solution, extracted with dichloromethane (containing 10% methanol), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 165n (3.64 g, 7.64 mmol, yield: 70.8%). MS m / z (ESI): 477 [M+1]+ Step 13: 165n (1 g, 2.10 mmol) was dissolved in dichloromethane (10 mL) and methanol (10 mL), and nickel acetate tetrahydrate (104.44 mg, 419.71 gmol) was added. Sodium borohydride (158.78 mg, 4.20 mmol) was slowly added in portions at room temperature, and the reaction system was reacted at room temperature for 3 minutes. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate, washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 165o (0.39 g, 0.81 mmol, yield: 38.8%). MS m / z (ESI): 479 [M+1]+ Step 14: 165o (1.3 g, 2.72 mmol) was dissolved in dichloromethane (30 mL) to form a clear solution. Carbon tetrabromide (3.60 g, 10.87 mmol) and triphenylphosphine (2.85 g, 10.87 mmol) were added, and the reaction system was stirred at room temperature for 3 hours. The reaction solution was directly concentrated, and the residue was purified by silica gel column chromatography using eluent system A to obtain 165p (1.27 g, 2.35 mmol, yield: 86.3%). MS m / z (ESI): 541 [M+1]+ Step 15: 165p (1.4 g, 2.59 mmol) was dissolved in acetonitrile (30 mL). 2-(Trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-amine (676.97 mg, 3.10 mmol), potassium carbonate (1.07 g, 7.76 mmol), and sodium iodide (775.15 mg, 5.17 mmol) were added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 80°C for 16 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (150 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 165q (726 mg, 1.07 mmol, yield: 41.4%). MS m / z (ESI): 679 [M+1]+ Step 16: 165q (762 mg, 1.12 mmol) was dissolved in tetrahydrofuran (10 mL), methanol (10 mL) and water (10 mL), lithium hydroxide monohydrate (141.33 mg, 3.37 mmol) was added, and the reaction system was reacted at 50°C for 3 hours. The reaction solution was concentrated to remove the organic phase, adjusted to neutral with 2N hydrochloric acid, extracted with dichloromethane (containing 10% methanol), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated to obtain 165r (553 mg, 831.99 pmol, yield: 74.1%). MS m / z (ESI): 665 [M+1]+ Step 17:  165r  (553 mg, 831.99 pmol) was dissolved in N,N- dimethylformamide (20 mL), N,N-diisopropylethylamine (215.05 mg, 1.66 mmol, 289.83 pL) and O-(7-azabenzotriazol-1-yl)-N,N,N‘,N‘-tetramethyluronium hexafluorophosphate (470.83 mg, 1.25 mmol) were added, and the reaction system was stirred at room temperature for 30 minutes. The resulting reaction system was quenched with water, extracted with ethyl acetate (50 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 165s (436 mg, 674.24 pmol, yield: 81.0%). MS m / z (ESI): 647 [M+1]+ Step 18: 165s (436 mg, 674.24 pmol) was added to trifluoroacetic acid (10 mL), and the reaction system was reacted at 80°C for 1 hour. The reaction solution was adjusted to pH=8-9 with a sodium bicarbonate aqueous solution, extracted with dichloromethane (containing 10% methanol), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain Example 165 (121 mg, yield: 36.15%). MS m / z (ESI): 497 [M+1]+ Examples 165-P1 & 165-P2 165                                   165-Pl                    165-P2 Example 165 (388 mg, 0.78 mmol) was separated by chiral preparative HPLC to obtain rel-(S)-(Z)-4-amino-12-(2-trifluoromethyl-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-1,3,9,10,11,12-hexahydro-13H-azonino[3,4-g]furo[3,4-c]quinolin-13-one  165-P1  (181 mg, yield: 46.6%) and rel-(R)-(Z)-4-amino-12-(2- trifluoromethyl-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-1,3,9,10,11,12-hexahydro-13H-azonino[3,4-g]furo[3,4-c]quinolin-13-one 165-P2 (177 mg, yield: 45.6%). 165-P1 (tR: 3.029 min): 1H NMR (400 MHz, DMSO-d6) 5 8.11 (dd, 1H), 7.86 (dd, 1H), 7.46 (d, 2H), 7.28 (d, 1H), 6.66 (s, 1H), 6.60 (q, 1H), 6.50-5.70 (m, 1H), 5.50-5.10 (m, 1H), 5.34 (s, 2H), 5.03 (s, 2H), 4.93-4.74 (m, 2H), 4.34-4.13 (m, 2H), 3.75-3.10 (m, 2H), 2.18-1.70 (m, 2H), 1.45-1.25 (m, 2H). 165-P2 (tR: 2.383 min): 1H NMR (400 MHz, DMSO-d6) 5 8.11 (dd, 1H), 7.86 (dd, 1H), 7.46 (d, 2H), 7.28 (d, 1H), 6.66 (s, 1H), 6.60 (q, 1H), 6.50-5.70 (m, 1H), 5.50-5.10 (m, 1H), 5.34 (s, 2H), 5.03 (s, 2H), 4.93-4.74 (m, 2H), 4.34-4.13 (m, 2H), 3.75-3.10 (m, 2H), 2.18-1.70 (m, 2H), 1.45-1.25 (m, 2H). Example 167 (Z)-4-Amino-12-(7-trifluoromethylisochroman-4-yl)-9,10,11,12-tetrahydro- 13H-azonino[4,3-g]imidazo[1,5-a]quinoxalin-13-one DMPM Referring to the synthesis method described in Step 6 to Step 9 of Example 62, Example 167 (7 mg, yield: 0.7%) was obtained from methyl (Z)-7-(6-bromopent-1-en-1-yl)-4-(2,4-dimethoxybenzylamino)imidazo[1,5-a]quinoxaline-8-carboxylate 62g (1.08 g, 2.00 mmol). MS m / z (ESI): 494 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 6 9.12 (d, 1H), 8.16 (dd, 1H), 7.90 (s, 1H), 7.66 (m, 2H), 7.57 (d, 1H), 7.38 (s, 2H), 7.16 (s, 1H), 6.60 (m, 1H), 6.15 (m, 1H), 5.77 (m, 1H), 4.90 (m, 1H), 4.75 (m, 1H), 4.45-4.10 (m, 2H), 3.85-2.95 (m, 2H), 2.15-1.60 (m, 2H), 1.42-1.10 (m, 2H). Example 171 (Z)-4-Amino-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-9,10,11,12-tetrahydro-13H-azonino[4,3-g]imidazo[1,5-a]quinoxalin-13-one Referring to the synthesis method described in Step 6 to Step 9 of Example 62, Example 171 (10 mg, yield: 2.9%) was obtained from methyl (Z)-7-(5-bromopent-1-en-1-yl)-4-((3,5-dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 171a (500 mg, 4.24 mmol). MS m / z (ESI): 453 [M+1]+ 1H NMR (400 MHz, MeOD) 6 9.08 (s, 1H), 8.88 (s, 1H), 8.21-8.08 (m, 2H), 7.96 (s, 1H), 7.74 (d, 1H), 7.33 (s, 1H), 6.59 (d, 1H), 6.08 (td, 1H), 5.18 (d, 1H), 4.56 (d, 1H), 3.65-3.44 (m, 2H), 2.20 (dt, 1H), 1.90 (dq, 2H), 1.50 (d, 1H). Alternatively, the following examples were prepared using the following method: Example 173 (Z)-4-Amino-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1,3,9,10,11,12- hexahydro-13H-azo[3,4-g]furo[3,4-c]quinolin-13-one Step         1:         Methyl         7-[(Z)-5-bromopent-1-enyl]-4-[(2,4- dimethoxyphenyl)methylamino]-1,3-dihydrofuro[3,4-c]quinoline-8-carboxylate 173a (0.7 g, 1.29 mmol) was dissolved in acetonitrile (20 mL). [5-(Trifluoromethyl)-2-pyridyl]methanamine (273.27 mg, 1.55 mmol), potassium carbonate (536.06 mg, 3.88 mmol), and sodium iodide (387.58 mg, 2.59 mmol) were added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 80°C for 16 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (100 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 173b (329 mg, 516.76 pmol, yield: 40.0%). MS m / z (ESI): 637 [M+1]+ Step 2: 173b (329 mg, 516.76 pmol) was dissolved in tetrahydrofuran (5 mL), methanol (5 mL) and water (5 mL), lithium hydroxide monohydrate (65.05 mg, 1.55 mmol) was added, and the reaction system was reacted at 50°C for 3 hours. The reaction solution was concentrated to remove the organic phase, adjusted to neutral with 2N hydrochloric acid, extracted with dichloromethane (containing 10% methanol), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated to obtain 173c (220 mg, 353.34 pmol, yield: 68.4%). MS m / z (ESI): 623 [M+1]+ Step 3: 173c (210 mg, 337.28 pmol) was dissolved in N,N-dimethylformamide (20 mL), N,N-diisopropylethylamine (65.38 mg, 505.92 pmol, 88.12 pL) and O-(7-azabenzotriazol-1 -yl)-N,N,N‘,N‘-tetramethyluronium hexafluorophosphate (190.87 mg, 505.92 pmol) were added, and the reaction system was stirred at room temperature for 30 minutes. The resulting reaction system was quenched with water, extracted with ethyl acetate (50 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 173d (188 mg, 310.94 pmol, yield: 92.2%). MS m / z (ESI): 604 [M+1]+ Step 4: 173d (188 mg, 310.94 pmol) was added to trifluoroacetic acid (10 mL), and the reaction system was reacted at 80°C for 1 hour. The reaction solution was adjusted to pH=8-9 with a sodium bicarbonate aqueous solution, extracted with dichloromethane (containing 10% methanol), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was subjected to reversed-phase preparative chromatography to obtain Example 173 (13.4 mg, 29.49 pmol, yield: 9.5%). MS m / z (ESI): 454 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 8.59 (s, 1H), 8.59 (s, 2H), 8.24 (dd, 1H), 7.74 (s, 1H), 7.69 (d, 1H), 7.52 (s, 1H), 6.62 (d, 1H), 6.07 (d, 1H), 5.46 (dd, 2H), 5.13-4.99 (m, 3H), 4.53 (d, 1H), 2.21-2.08 (m, 1H), 2.05-1.87 (m, 1H), 1.70 (d, 2H), 1.40 (s, 1H), 1.27 (d, 1H) Example 176 4-Amino-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazonino[8,7-g]quinoxalin-13(7H)-one Referring to the method described in Step 5 to Step 8 of Example 14, Example 176 (10 mg, yield: 5.3%) was obtained from methyl 7-((3-bromopropoxy)methyl)-4-((3,4-dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 14e (220 mg, 0.41 mmol). MS m / z (ESI): 457 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.20 (d, 1H), 9.02 - 8.97 (m, 1H), 8.24 (dd, 1H), 8.09 (s, 1H), 7.91 (d, 1H), 7.80 (d, 1H), 7.40 (d, 3H), 5.21 (d, 1H), 4.65 (d, 1H), 4.56 - 4.43 (m, 2H), 3.50 (t, 4H), 1.25 (d, 2H). Alternatively, the following examples were prepared using the following method: Example 177 4-Amino-9-methyl-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazolo[8,7-g]quinoxalin-13(7H)-one Step 1: 7.7-Dimethyl-4-[(2,4-dimethoxyphenyl)methylamino]imidazo[1,5-a]quinazoline-8-carboxylate 177a (4 g, 8.49 mmol), [3-(1,3-dioxoisoindolin-2-yl)-1-methylpropoxy]methylboronic acid (3.53 g, 12.73 mmol), [n-butyl-di(1-adamantyl)phosphine](2-amino-1,1'-biphenyl-2-yl)palladium(II) methanesulphonate (1.85 g, 2.55 mmol), and potassium phosphate (5.40 g, 25.46 mmol) were dissolved in dioxane (50 mL) and water (10 mL), and the mixture was purged three times with nitrogen, and stirred at 110°C for 16 hours. The resulting reaction system was cooled to room temperature, quenched with water, extracted with ethyl acetate (60 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 177b (3.5 g, yield: 66.1%). MS m / z (ESI): 624 [M+1]+ Step 2: 177b (500 mg, 801.73 pmol) was dissolved in ethanol (10 mL), hydrazine hydrate (141.65 mg, 2.41 mmol, 85% purity) was added, and the system was reacted at 80°C for 16 hours. The resulting reaction system was cooled to room temperature and filtered, and the solid was dried to obtain 177c (210 mg, yield: 53.1%). MS m / z (ESI): 494 [M+1]+ Step 3: 177c (1 g, 2.03 mmol) and 5-(trifluoromethyl)pyridine-2-carbaldehyde (425.75 mg, 2.43 mmol) were dissolved in methanol (50 mL), followed by the addition of acetic acid (243.35 mg, 4.05 mmol) and sodium cyanoborohydride (381.96 mg, 6.08 mmol), and the system was reacted at 25°C for 16 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (60 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 177d (400 mg, yield: 30.2%). MS m / z (ESI): 525 [M+1]+ Step 4: 177d (32.6 mg, 49.95 pmol) was dissolved in tetrahydrofuran (1 mL), water (1 mL) and methanol (1 mL), lithium hydroxide (10.48 mg, 249.75 pmol) was added, and the reaction system was reacted at 25°C for 16 hours. The resulting reaction system was adjusted to pH 5-6 with 1 M dilute hydrochloric acid, extracted with ethyl acetate (5 mL x 3), washed with a saturated sodium chloride aqueous solution (30 mL), dried over anhydrous sodium sulphate, filtered, and concentrated to obtain 177e (31 mg, yield: 97.1%). MS m / z (ESI): 639 [M+1]+ Step 5: 177e (451.8 mg, 707.45 pmol) and N,N-diisopropylethylamine (548.58 mg, 4.24 mmol, 739.33 pL) were dissolved in N,N-dimethylformamide (10 mL), 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium      hexafluorophosphate (533.80 mg, 1.41 mmol) was added, and the reaction system was reacted at 25°C for 16 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (80 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 177f (430 mg, yield: 97.9%). MS m / z (ESI): 621 [M+1]+ Step 6: 177f (400 mg, 644.52 pmol) was dissolved in trifluoroacetic acid (8 mL), and the reaction system was reacted at 80°C for 0.5 hours. Upon completion of the reaction as monitored by LCMS, the reaction solution was subjected to rotary evaporation to dryness to obtain a crude product, which was purified by preparative liquid chromatography to obtain Example 177 (205.8 mg, yield: 67.8%). MS m / z (ESI): 471 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.22 (s, 1H), 9.00 (d, 1H), 8.29 - 8.19 (m, 1H), 8.07 (s, 1H), 7.94 (s, 1H), 7.78 (dd, 1H), 7.48 (s, 2H), 7.39 (d, 1H), 5.22 (dd, J = 16.1, 7.2 Hz, 1H), 4.85 (dd, 1H), 4.52 (dd, 1H), 4.32 (dd, 1H), 3.43 (d, 2H), 3.23 (d, 1H), 1.68 (dd, 1H), 1.18 (s, 1H), 1.12 (t, 3H). Example 178 4-Amino-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolino[7,8-g]quinolin-13(1H)-one Referring to the synthesis method of Example 14, Example 178 (25 mg, yield: 0.9%) was obtained from 3-(benzyloxy)propan-1-ol 178a (1 g, 6 mmol). MS m / z (ESI): 459 [M+1]+ 5        1H NMR (400 MHz, DMSO-d6) 6 8.97 (d, 1H), 8.24 (dd, 1H), 7.76 (d, 1H), 7.61 (s, 1H), 7.52 (s, 1H), 5.42 (s, 2H), 5.19 (d, 1H), 5.06 (s, 2H), 4.74 (d, 1H), 4.58 (d, 1H), 4.45 (d, 1H), 3.81 (d, 1H), 3.44 (m, 1H), 3.26 (m, 2H), 1.91 (m, 1H), 1.23 (d, 1H). Example 184 10          4-Amino-3-methyl-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)- 3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolo[7,8-g]quinoxalin-13(1H)-one Referring to the synthesis of Example 178, Example 184 (12.5 mg, yield: 0.6%) was obtained from methyl 2-methyl-4-oxotetrahydrofuran-3-carboxylate 184a (500 mg, 3.16 mmol) through steps of coupling, deprotection, bromination, substitution, hydrolysis, cyclisation, and deprotection. MS m / z (ESI): 473[M+1]+ 1H NMR (400 MHz, DMSO-d6) S 8.96 (d, 1H), 8.26 - 8.22 (m, 1H), 7.75 (m, 1H), 7.50 (s, 1H), 7.38 (s, 1H), 6.56 (s, 2H), 5.47 - 5.24 (m, 4H), 5.19 (m, 1H), 4.71 (m, 1H), 4.53 (m, 1H), 4.43 (d, 1H), 3.77 (d, 1H), 3.23 (d, 2H), 2.03 - 1.88 (m, 2H), 1.40 (d, 3H). Example 184-P1 (R)-4-Amino-3-methyl-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolo[7,8-g]quinoxalin-13(1H)-one Step 1 Compound 184i was separated by chiral preparative HPLC to obtain 184-P1a (200 mg) and 184-P2a (220 mg). MS m / z (ESI): 561[M+1]+ Referring to Step 8 to Step 11 of Example 14, Example 184-P1 (22 mg) was obtained from 184-P1a (200 mg, 0.394 mmol) through steps of substitution, hydrolysis, cyclisation, and deprotection. MS m / z (ESI): 473 [M+1]+ 1HNMR (400 MHz, DMSO-d6) S 8.96 (d, 1H), 8.26 - 8.22 (m, 1H), 7.75 (m, 1H), 7.50 (s, 1H), 7.38 (s, 1H), 6.56 (s, 2H), 5.47 - 5.24 (m, 4H), 5.19 (m, 1H), 4.71 (m, 1H), 4.53 (m, 1H), 4.43 (d, 1H), 3.77 (d, 1H), 3.23 (d, 2H), 2.03 - 1.88 (m, 2H), 1.40 (d, 3H). Example 184-P2 (S)-4-Amino-3-methyl-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolo[7,8-g]quinoxalin-13(1H)-one Referring to the preparation of Example 184-P1, Example 184-P2 (18 mg) was obtained from 184-P2a (220 mg, 0.394 mmol) through steps of substitution, hydrolysis, cyclisation, and deprotection. MS m / z (ESI): 473 [M+1]+ 1HNMR (400 MHz, DMSO-d6) 5 8.96 (d, 1H), 8.26 - 8.22 (m, 1H), 7.75 (m, 1H), 7.50 (s, 1H), 7.38 (s, 1H), 6.56 (s, 2H), 5.47 - 5.24 (m, 4H), 5.19 (m, 1H), 4.71 (m, 1H), 4.53 (m, 1H), 4.43 (d, 1H), 3.77 (d, 1H), 3.23 (d, 2H), 2.03 - 1.88 (m, 2H), 1.40 (d, 3H). Example 190 4-Amino-1-methyl-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1,7,9,10,11,12-hexahydro-13H-[1,5]oxazolo[7,8-g]pyrazolo[4,3-c]quinolin-13- one Referring to the preparation method of Example 165, Example 190 (17 mg, yield: 2.6%) was obtained from methyl 4-amino-2-bromobenzoate 190a (5 g, 21.73 mmol). MS m / z (ESI): 471 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 8.97 (d, 1H), 8.38 (s, 1H), 8.26 (dd, 1H), 8.07 (s, 1H), 7.80 (d, 1H), 7.59 (s, 2H), 5.20 (d, 1H), 4.75 (d, 1H), 4.55 (dd, 2H), 3.81 (dt, 1H), 3.54 - 3.36 (m, 3H), 3.26 (d, 3H), 1.90 (q, 1H), 1.25 (d, 1H). Example 214 4-Amino-12-(4-(pentafluoro-Z6-sulphanyl)benzyl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazonino[8,7-g]quinoxalin-13(7H)-one Referring to the synthesis of Example 14, Example 214 (10 mg, yield: 5.3%) was    obtained    from methyl    7-((3-bromopropoxy)methyl)-4-((3,4- dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 14e (220 mg, 5   0.41 mmol). MS m / z (ESI): 514 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.21 (d, 1H), 8.10 (s, 1H), 7.93 (d, 3H), 7.69 (d, 2H), 7.40 (d, 3H), 5.24 (d, 1H), 4.57 (dd, 2H), 4.31 (d, 1H), 3.75 (d, 1H), 3.46 (t, 1H), 3.29 (s, 1H), 3.10 (d, 1H), 1.92 (dd, 1H), 1.20 (d, 1H). The following examples were prepared by reference to Example 62: Example Structure MS m / z (ESI) [M+1]+ Example Structure MS m / z (ESI) [M+1]+ 284 H,N \   / % N v \ J       f N    N-^          i / =\      / A <\__ 488 350 Cif A 2=, O XiZ £ 524 285 H2N 2 \ An r \ JI N A <0 rrOn Ox__ / .Z:;N 487 351 H,N \ A \ J] N   N-^ / \      CF3 \   7 467 286 Z=\ VaZ v / Z=, O ) xz ? s 488 352 ‘A Z^N Ta j N / X     CFj A°0 ( / nA 467 287 H2N    z^ 2 \ An A \ J N (rfp <\__zn^ / -n 519 352-P1 H,N A j N N-^ ZX     CF, W A \ 7 v N^\ N 467 288 H2N \   / % N / r\ j N V <\_Z^.Y\ 451 352-P2 H,N H j N ,CF3 ( LUn 467 289 H2N 2 \Zn v \ J F N i 55z 484 353 H2Nv^n Ua jj N yu )= o / ^N  7=X / H^CF3 ()- / 510 290 H2N \  7% N H J N ,Z\^O ZYf Y n । L ; F _zv^ 483 354 H,N \ Z^N JJ N ,CF3 W #-Y 3 Y^r°CJN o' 511 291 H,N 2 \ Z^N J N   N"^ )={     F^Y x w JU n r L > f \_Y^ 484 355 H,N \      N X \ J N JU )=o / r~ N    / =\ HX ()U 510 292 H,N \ U^N NZ Cl"'55\ V /      5===5 z V° YYf Y Il r             y ci _ / .z:\ 515 356 H,N    ~ \ z> )r\ jj ,cF-< W / 5 / r°JjN —2  n«Y\ ''-o' 511 293 H2Yy5n <5 fzY 5-0' 501 357 H,N \ Z N N ■5<" 513 294 £ ........ /  0     ^2 502 358 H,N \   / ^N Z \ JJ N / X     CF, W H fYy°w F \   n"a\ v-() 531 295 H2y^(N OJ ci~f) fix- 533 359 H2N 2 \ / ^N k \ J N N^ 509 296 H,N 2 \ / Z~N \ J     ____ N    N          Z^ \\ ( ^L7"n 465 360 H,N j N   N"^ CF, J / ' z==<N —-V    N^ / A 509 297 H2N \ / sN     F J      k-XT N N^      / / N )=(      V / F W o L / "N 502 361 H,N    ~ 2 F \ J N 513 298 H,N 2 \ Zx J    z^ VzN F O    N— / N 501 362-P1 H,N ~ W5N N - 509 299 H2N^fN OJ f-<') 502 363 H,N 2 \   / ^N )r\ j N 509 300 H2N \ / ^N r \ J    ___ NwN r^v°     31 533 364 H2N H J N N"^ o- / 1             / =\ )\\ ^CF3 \ / N o-' 499 301 H,N    ~ ) \ N 465 365 H2N X N CF, W H ^fY°vjN '\ n*az\ 509 302 H2N \               F NZ           / ^~N W" 502 366 H,N    ~ \ / Z N r \ J N   N"^ ,CF3 W H <froC= / N ^~o7 509 303 H,N    ~ J          .____. NwN F~Y^ ?—\^° \ > F O N— / N 501 367 H,N \ zZ N H j N N"^ / X     CF, ( /     N^ / A ^~o7 507 304 H2y^N OJ 502 368 H,N    ~ zM j N N-^ / \      ,CF3 / Y°O ^~o7 509 305 h2n O c'~O M7 533 369 H,N    ~ \    / / N r \ j N N"^ / X     CF, W / W / Y°CJN ''"'A'    ^o7 509 306 H,N 465 370 H2N 7^ \ JJ N N-^ ft-"' —o7 497 307 h2n J N A fr° y VCF' N 424 371 H,N \ A^n A \ JJ N / X     CF, vJ A~ / o^XA^o J \\ I X^n 469 308 H,N / r \ j N C /     . XFj frfT _ / <y'\ 439 372 H;N\ A"n 4 \ jl N   N"^ O’ [ / ° o-^Nv / =\ ycF3 457 309 H2N / x aO N 495 373 H,N \ 4 \ J N   N-^ y) o'^ro 1     N    z=\ / ycF3 471 310 H,N \ .AN / / \ JJ N C /        cf3 <Y°rY ^nL / ^ 439 374 h2n ~ \ / ^N / \ JJ N O-^ >o /   z—N    / =\ W\ / ACF3 / 471 311-P1 H2N\ yN / r \ jj N %- ^oz 481 375 H,N \ .Z^N / r \ j N ^~S >o /   z— N    / =\ )-4 / Vcf3 7    N-77 471 312 H2N V- / X / r \ jj N 482 376 h2n w? N N-^ yr 457 313 H2N H j N W' 453 377 H2N ^Jn N   N"^ fifi ^-o7  )=O fi / ^N fifi\ / / CF’ \ / N o— / 499 313-P1 H,N 2 \ Z^ N fifi J N (fi?..... 453 378 H,N    ~ \ / Z N fiA J N N-^ r'0^”^0 fi / ^N 484 313-P2 H,N    ~ r \ J N \ /         cf3 fr °fT ' fi___ 453 379 H1N\ Z^N J N   N"^ fi-o" 457 314 H,N \ / fi N \ J N . fizz" 499 380 H,N 2 \ Z^N 4 \ JJ N &fi“ 471 315 H2N 2 VZ^N j N N^ fiyfi "o^ 517 381 H,N fix J N N-^ / \      zCF3 fi^v0 \ ? \    N-^ / N V^NH 454 316 H2N 2 \ / ^n fix J N N^ &z" '<) 495 382 H2N x-O N fiz / " 468 317 H,N \ Fn r\ jj N X / W \= / / xX UfY 495 383 h2n X N N-^ 455 318 H,N \ Fn j N X 'Bw“ 495 384 H,N \ Fn Fa j N (\      zCF3 W f~Y 8 T / n 451 319 h2n \ Fn FA J N 1X W   _ XF3 rr°rr ox__ 457 385 H2\ Ax Fa j N   N"^ / \       / CF3 or Lfn 456 320 H2N 2 J N AyT N H 440 386 "2N\ Xn FA J| N   N-^ / CF3 aF°F^ 451 321 H2N 2 \ / ^N F \ J N N^ Sa'" \ 454 387 H,N \ Xn Fa j N   N-^ / CF3 aa°F^ ( IF 470 322 H2N X? N >dF'" o 441 388 h2n )r\ j N   N <F 470 323 H,N \ Fn Fa j N X Zy° XycF, \ nxa 480 389 H2N \ X N F \ J N ?X ftF 488 324 H,N 4A JJ N \ 7          sf5 497 390 H2N \    / % N H j N ( XJa Va F 472 325-P1 H2N W5N N N"^ H°rrcF3 O 466 391 H2N \ , / ^N H j N N-"^ m-c 454 326 s r \ ° ° v} IZ ’ll <ti 524 392 H,N \ N N-^ Q "H” / \^° \ ,N 471 327 H,N NwN f- / A < / / ) F O    N— / N 501 393 H,N / T \ J N N"^ / ^YCF’ w AJ ZX^° S\ / W     \   )=N V     N—- / 509 328 H2y^7 < / J F~C1 M- 502 394 H,N / M J N C.V 492 329 Hiy^N OJ c,'D 533 395 H2N \ j N   N-^ / \     CF3 w LAn 467 330 H,N / A J      z--- N         / A 465 396 ”2N\ / ^n j N N"^ zCF3 V n\ 508 331 K pax X n J71 425 397 H2N \ / z N / r\ jj N m-<CF3 471 332 H,N \ J N X X         cf3 _ / mS 439 398 H;N\ / M N v\ JI N   N"^ i \     Cl / “-F3 w w Z^\z° \  ') 487 333 H,N 2 \ / \ x \ JJ N C X ~ ,cf3 _ / N^z^n 439 399 Ui' W - V jaj 471 334 H,N J N ft-tf" 439 400 H2N \  , / ^N H jj N / \      zCF3 jjj^" 454 335 H2N Mj N   N"^ W    XF3 ^nLA / n '() 481 401 H2N \ / ^N JJ N   N*^ / \      zCF3 w / \^°\ J y   T / ^n \    A-n H 453 336 H,N \ Z N H j N X X         cf3 rr°^ ' GyY 483 402 H,N    -. \ Z N H j] N zCF3 \ \\ J    L \     / ~N \ 467 337 H,N H j N I'M / A Vx <Y°fY 495 403 H,N \ Z N / T \ JI N Z\       / CF3 J—\^ON / /    T -^N \     / ~N <_> H 454 338 H,N     ,. r \ J N fY°fT J NrJ^N F        '   ]     \ 499 404 H,N \ Fn V \ J] N Z\       / CF3 w w  T H \     / ~N \ 468 339 H2N FX N   N"^ \= /   ^\ / CF3 1' / V^O ]|      ' F. N <) 517 405 H,N    ~ 2 FA J N N"^ / A ° w N. v vo n\JL / -n / =^ )\\ / / CF3 ( / N ()z 550 340 H,N    ~ \ F N fa j N rF \= /     / \ / CF3 'O^ 495 406 H,N FA J N N"^ <M> N-N- / ~>O n\JL^n ,=^ W\ / FCF3 \ / n 536 341 H,N \   / / N FA J N tF / A YVfv U^y 495 407 H2N \   / % N / r\ j N N"^ y} / — / yo N-^x N    / =. N.-      )\\ / / ^CF3 N   ( Vn o— / 536 342 H,N \ / / N t \ J N N"^ / A \= /    / -.f vy°yY ^oz 495 408 H,N \ Fa FA j N N"^ / A N-N-^FO u / > / ^N   / =. N~~^      ^cf3 \ / N o-^ 522 343 paX —( o M n 457 409 H2N \ / r\ j N N"^ y) / —   / ^° N-N   N    / =x / / CF3 \ / N o— / 536 344 X'Xf O ^=2 n 440 410 H,N    ~ xXN H j N 1>X ££ >o ,N~N   N    / =\ £cf3 \ / N 522 345 H,N 2 \ Z^N r\ j px" N \ 454 411 H2N 2 \Z^N / M J y) / —   / ^° / =\ N / =\ Nx      )--(\   / ^CF3 N    ( FN 536 346 c :p < O ^-2 n 441 412 H,N kXj" N N-^ y} 2=0 *2 A / =\ n-n-x yp acfj \ / N 522 347 X pix °X) n 480 413 H,N / r\ ji N   N"^ / /      sf5 w n~£"n 511 348 H,N    ~ \ x n H j N \ / /      _ sf5 ^n££^n 497 414 H,N 2 \An H ji N N"^ / \      SF, W / Ap p\2°\ O^^N— / N 515 349 HzN\ / Xn XX J N / \^° X . ,CF, ' £ r \ N<Zv o 466 Alternatively, the following examp es were prepared using the following method: Example 250 4-Amino-11-(5-(trifluoromethyl)pyridin-2-yl)methyl-8,9,10,11-tetrahydroazocino[4,3-g]imidazo[1,5-a]quinoxalin-12(7H)-one Referring to the synthesis method described in Step 4 to Step 9 of Example 62, Example 250 (15 mg, yield: 7.4%) was obtained from methyl (Z)-7-(5-bromobut-1-en-1-yl)-4-((3,5-dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 157c. MS m / z (ESI): 441 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 8 9.40 (s, 1H), 8.97 (d, 1H), 8.32 (s, 1H), 8.28 (s, 1H), 8.24 (dd, 1H), 7.66 (d, 1H), 7.42 (s, 1H), 5.17 (d, 1H), 4.65 (d, 1H), 3.24 (d, 2H), 2.95 (dd, 1H), 2.76 (t, 1H), 2.19 - 2.08 (m, 1H), 1.84 (d, 1H), 1.67 (d, 1H), 1.46 (d, 1H). Alternatively, the following examples were synthesised by reference to the following preparation method: Example 268 4-Amino-12-(6-trifluoromethyl-2,3-dihydrobenzofuran-3-yl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazonino[8,7-g]quinoxalin-13(7H)-one Referring to the synthesis method of Example 14, Example 268 (20 mg, yield: 7.5%) was obtained from methyl 7-((3-bromopropoxy)methyl)-4-((3,4-dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 14e (300 mg, 0.55 mmol) and 6-(trifluoromethyl)-2,3-dihydrobenzofuran-3-amine (168 mg, 0.83 mmol). MS m / z (ESI): 484 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 8 8.39 (dd, 2H), 8.05 (s, 1H), 7.52 (d, 1H), 7.49 - 7.36 (m, 2H), 7.29 (dq, 1H), 5.15 (td, 1H), 4.84 (d, 2H), 4.57 (dd, 1H), 4.32 (m, 1H), 3.71 (m, 1H), 3.55 (m, 3H), 1.90 (m, 2H). Example 270 4-Amino-1-methyl-12-(6-(trifluoromethyl)-2,3-dihydrobenzofuran-3-yl)-1,7,9,10,11,12-hexahydro-13H-[1,5]oxazonino[7,8-g]pyrazolo[4,3-c]quinolin-13-one Step 1: Methyl 4-amino-2-bromo-carboxylate 270a (10.00 g, 43.67 mmol) and N-iodosuccinimide (10.13 g, 45.00 mmol) were dispersed in acetonitrile (100 mL). The mixture was stirred and reacted at 25°C for 16 hours. The reaction solution was filtered to remove insoluble materials. The filtrate was concentrated under reduced pressure to dryness, and the resulting residue was purified by silica gel column chromatography using eluent system A to obtain 270b (14.00 g, yield: 90.3%). MS m / z (ESI): 356 [M+1]+ Step 2: 270b (9.00 g, 25.35 mmol), 1-methyl-1H-pyrazole-5-boronic acid pinacol       ester       (10.55       g,       50.70       mmol),       [1,1'- bis(diphenylphosphino)ferrocene]palladium(II) dichloride (1.86 g, 2.54 mmol), and potassium phosphate (10.75 g, 50.70 mmol) were dispersed in 1,4-dioxane (150 mL) and water (30 mL). The mixture was stirred and reacted at 80°C for 16 hours. The reaction solution was filtered to remove insoluble materials. The filtrate was concentrated under reduced pressure to dryness, and the resulting residue was purified by silica gel column chromatography using eluent system A to obtain 270c (6.50 g, yield: 83.0%). MS m / z (ESI): 310 [M+1]+ Step 3: 270c (6.50 g, 21.04 mmol) and N,N'-carbonyldiimidazole potassium phosphate (6.82 g, 42.08 mmol) were dispersed in N-methylpyrrolidone (65 mL). The mixture was stirred and reacted at 150°C for 1 hour. The reaction solution was poured into water (650 mL), and the precipitated solid was filtered to obtain 270d (5.71 g, yield: 81.0%). MS m / z (ESI): 336 [M+1]+ Step 4: 270d (5.71 g, 17.04 mmol), 2,4-dimethoxybenzylamine (5.69 g, 34.08 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (5.18 g, 34.08 mmol) and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (15.06 g, 34.08 mmol) were dispersed in dimethyl sulphoxide (50 mL). The mixture was stirred and reacted at 25°C for 1 hour. The reaction solution was poured into water (500 mL), and the precipitated solid was filtered to obtain 270e (6.41 g, yield: 77.7%). MS m / z (ESI): 485 [M+1]+ Referring to the synthesis method of Example 14, Example 270 (35 mg, yield: 6.8%) was obtained from 270e (500 mg, 0.41 mmol). MS m / z (ESI): 498 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 8.52 (s, 2H), 8.25 - 7.93 (m, 1H), 7.77 -7.58 (m, 2H), 7.29 (dd, 2H), 6.06 - 5.79 (m, 1H), 4.99 - 4.77 (m, 3H), 4.54 - 4.44 (m, 4H), 3.82 (dd, 1H), 3.42 - 3.39 (m, 2H), 3.30 - 3.10 (m, 2H), 1.67 - 1.24 (m, 1H), 1.09 (dd, 1H). Example 298 4-Amino-12-((5-(2,6-difluorophenyl)pyridin-2-yl)methyl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazolo[8,7-g]quinoxalin-13(7H)-one Referring to the synthesis of Example 62, Example 298 (25 mg, yield: 13.1%) was     obtained     from     methyl     7-((3-bromopropoxy)methyl)-4-(3,4- dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 298a (200 mg, 0.37 mmol). MS m / z (ESI): 501 [M+1]+ 1H NMR (400 MHz, MeOD) 5 9.32 (s, 1H), 8.68 (s, 1H), 8.37 (d, 2H), 8.06 (m, 1H), 7.82 (m, 1H), 7.57 (s, 1H), 7.54-7.46 (m, 1H), 7.19-7.15 (m, 2H), 5.42 (d, 1H), 4.90-4.86 (m, 1H), 4.59 (d, 1H), 4.49 (d, 1H), 3.97 (d, 1H), 3.58-3.39 (m, 3H), 2.232.02 (m, 2H). Example 311 (Z)-4-((2,4-Dimethoxybenzyl)amino)-13-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-10,11,12,13-tetrahydroazocino[4,3-g]imidazo[1,5-a]quinoxalin-14(9H)-one Step 1: 2-(Trifluoromethyl)-8H-pyrano[3,4-b]pyridin-5-one 311a (3 g, 13.82 mmol) and hydroxylamine hydrochloride (960 mg, 13.82 mmol) were dissolved in ethanol (30 mL) and sodium acetate (3.40 g, 41.45 mmol), and the mixture was purged three times with nitrogen. The system was reacted at 80°C for 1 hour. The resulting reaction system was cooled to room temperature, concentrated, quenched with water, extracted with ethyl acetate (100 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 311b (3.10 g, yield: 96.7%). MS m / z (ESI): 233 [M+1]+ Step 2: 311b (20.98 g, 90.37 mmol), zinc powder (59.08 g, 903.69 mmol) and ammonium chloride (48.34 g, 903.69 mmol) were dissolved in ethanol (40 mL), and the mixture was reacted at 50°C for 4 hours. The resulting reaction system was filtered, concentrated, and slurried with dichloromethane, to obtain 311c (12.6 g, yield: 63.9%). MS m / z (ESI): 219 [M+1]+ Step 3: 311d (20 g, 42.44 mmol) and cuprous iodide (1.62 g, 8.49 mmol) were dissolved in N,N-dimethylformamide (200 mL) and triethylamine (14.17 g, 140.04 mmol, 19.53 mL), and the mixture was purged three times with nitrogen. 3-Butyn-1-ol (14.87 g, 212.18 mmol) and bis(triphenylphosphine)palladium(II) dichloride (2.98 g, 4.24 mmol) were added, and the resulting mixture was purged three times with nitrogen. The system was reacted at 40°C for 16 hours. The resulting reaction system was cooled to room temperature, concentrated, quenched with water, extracted with ethyl acetate (60 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated to obtain 311e (19 g, crude). MS m / z (ESI): 461 [M+1]+ Step 4: 311e (1.8 g, 3.91 mmol) and Raney nickel (4.59 g, 78.18 mmol) were dissolved in tetrahydrofuran (250 mL) and methanol (50 mL), and the mixture was purged three times with hydrogen, and reacted at 25°C under a hydrogen balloon for 2 hours. The resulting reaction system was filtered and concentrated to obtain 311f (1.6 g, crude). MS m / z (ESI): 463 [M+1]+ Step 5: 311f (4.8 g, 10.38 mmol) was dissolved in dichloromethane (50 mL), and the mixture was purged three times with nitrogen and cooled to 0°C. Triphenylphosphine (10.89 g, 41.51 mmol) and carbon tetrabromide (13.77 g, 41.51 mmol) were then added, and the system was reacted at 25°C for 2 hours. The resulting reaction system was concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain methyl (Z)-7-(4-bromobut-1-en-1-yl)-4-((2,4-dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 311g (3 g, yield: 55.2%). MS m / z (ESI): 525 [M+1]+ Step 6: 311g (1.5 g, 2.86 mmol), 2-(trifluoromethyl)-5,8-dihydro-6H- pyrano[3,4-b]pyridin-5-amine (1.25 g, 5.71 mmol), and sodium iodide (855.87 mg, 5.71 mmol) were dissolved in acetonitrile (40 mL), ground potassium carbonate (1.18 g, 8.57 mmol) was added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 80°C for 15 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (80 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 311h (252 mg, yield: 13.5%). MS m / z (ESI): 662 [M+1]+ Step 7: 311h (252 mg, 380.86 pmol) was dissolved in tetrahydrofuran (2 mL), water (2 mL) and methanol (2 L), lithium hydroxide (63.92 mg, 1.52 mmol) was added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 25°C for 16 hours. The resulting reaction system was adjusted to pH 5-6 with 1 M dilute hydrochloric acid, extracted with ethyl acetate (50 mL x 3), washed with a saturated sodium chloride aqueous solution (30 mL), dried over anhydrous sodium sulphate, filtered, and concentrated to obtain 311i (242 mg, crude). MS m / z (ESI): 648 [M+1]+ Step 8: 311i (240 mg, 370.57 pmol) and 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (279.61 mg, 741.15 pmol) were dissolved in N,N-dimethylformamide (3 mL), N,N-diisopropylethylamine (287.36 mg, 2.22 mmol, 387.28 pL) was added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 25°C for 16 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (80 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system A to obtain 311j (195 mg, yield: 84%). MS m / z (ESI): 630 [M+1]+ Step 9: 311j (190 mg, 301.29 pmol) was dissolved in trifluoroacetic acid (5 mL), and the mixture was purged three times with nitrogen. The reaction system was reacted at 90°C for 0.5 hours. Upon completion of the reaction as monitored by LCMS, the reaction solution was subjected to rotary evaporation to dryness to obtain a crude product, which was purified by preparative liquid chromatography to obtain Example 311 (76 mg, yield: 52.5%). MS m / z (ESI): 481 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.18 (d, 1H), 8.22 (s, 1H), 8.15-8.05 (m, 1H), 8.01-7.89 (m, 1H), 7.84 (dd, 1H), 7.62 (s, 2H), 7.18 (d, 1H), 6.59 (ddd, 1H), 5.91 (m, 1H), 5.55 (d, 1H), 4.94-4.74 (m, 2H), 4.34-4.12 (m, 2H), 3.80-3.62 (m, 2H), 3.16 (d, 1H), 2.76 (td, 1H). Examples 311-P1 & 311-P2 Example 311 (76 mg, 0.16 mmol) was separated by chiral preparative HPLC to obtain rel-(S)-(Z)-4-((2,4-dimethoxybenzyl)amino)-13-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-10,11,12,13-tetrahydroazocino[4,3-g]imidazo[1,5-a]quinoxalin-14(9H)-one 311-P1 (35 mg, yield: 46.1%) and rel-(R)-(Z)-4-((2,4-dimethoxybenzyl)amino)-13-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-10,11,12,13-tetrahydroazocino[4,3-g]imidazo[1,5-a]quinoxalin-14(9H)-one 311-P2 (36 mg, yield: 47.3%). 311-P1 (tR: 5.346 min): 1H NMR (400 MHz, DMSO-d6) 5 9.40 (d, 1H), 9.21 (br s, 2H), 8.38 (s, 1H), 8.30 (d, 1H), 8.14-7.75 (m, 2H), 7.29 (d, 1H), 6.62 (dd, 1H), 6.01 (m, 1H), 5.56 (s, 1H), 4.85 (qd, 2H), 4.26 (m, 2H), 3.77 (m, 1H), 2.80 (m, 1H), 2.50-1.78 (m, 2H). 311-P2 (tR: 4.447 min): 1H NMR (400 MHz, DMSO-d6) 5 9.40 (d, 1H), 9.21 (br s, 2H), 8.38 (s, 1H), 8.30 (d, 1H), 8.14-7.75 (m, 2H), 7.29 (d, 1H), 6.62 (dd, 1H), 6.01 (m, 1H), 5.56 (s, 1H), 4.85 (qd, 2H), 4.26 (m, 2H), 3.77 (m, 1H), 2.80 (m, 1H), 2.50-1.78 (m, 2H). Example 313 4-Amino-11-(1-(5-(trifluoromethyl)pyridin-2-yl)ethyl)-10,11-dihydroazocino[4,3-g]imidazo[1,5-a]quinoxalin-12(9H)-one Referring to the synthesis of Example 62, Example 313 (102 mg, yield: 25.1%) was     obtained     from     methyl     Z-7-(6-bromopent-1-en-1-yl)-4-((2,4- dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 157d (500 mg, 0.55 mmol). MS m / z (ESI): 453 [M+1]+ Examples 313-P1 & 313-P2 Example 313 (102 mg, 0.23 mmol) was separated by chiral preparative HPLC to obtain rel-(R,Z)-4-amino-11-(1-(5-(trifluoromethyl)pyridin-2-yl)ethyl)-10,11-dihydroazocino[4,3-g]imidazo[1,5-a]quinoxalin-12(9H)-one 313-P1 (38 mg, yield: 37.2%) and rel-(S,Z)-4-amino-11-(1-(5-(trifluoromethyl)pyridin-2-yl)ethyl)-10,11-dihydroazocino[4,3-g]imidazo[1,5-a]quinoxalin-12(9H)-one 313-P2 (42 mg, yield: 41.2%). 313-P1 (tR: 1.100 min): 1H NMR (400 MHz, DMSO-d6) 5 9.17 (s, 1H), 8.97 (s, 1H), 8.21 (d, 1H), 8.10 (s, 1H), 7.89 (s, 1H), 7.69 (dd, 1H), 7.44 (s, 2H), 7.15 (d, 1H), 6.57 (dd, 1H), 5.90 - 5.47 (m, 2H), 3.78 (dt, 1H), 3.56 - 3.38 (m, 1H), 2.47 -2.21 (m, 2H), 1.73 (dd, 3H). 313-P2 (tR: 1.490 min): 1H NMR (400 MHz, DMSO-d6) 5 8.97 (s, 1H), 8.21 (d, 1H), 8.10 (s, 1H), 7.89 (s, 1H), 7.69 (dd, 1H), 7.43 (s, 2H), 7.15 (d, 1H), 6.57 (dd, 1H), 5.94 - 5.47 (m, 2H), 3.91 - 3.44 (m, 2H), 2.45 - 1.98 (m, 2H), 1.73 (t, 3H). Example 325 (Z)-4-Amino-11-(6-(trifluoromethyl)-2,3-dihydrobenzofuran-3-yl)-10,11-dihydroazo[4,3-g]imidazo[1,5-a]quinoxalin-12(9H)-one DMPM Step 1:   Methyl 7-bromo-4-((2,4-dimethoxybenzyl)amino)imidazo[1,5- a]quinoxaline-8-carboxylate 325a (20 g, 42.44 mmol) and cuprous iodide (1.62 g, 8.49 mmol) were dissolved in N,N-dimethylformamide (200 mL) and triethylamine (14.17 g, 140.04 mmol, 19.53 mL), and the mixture was purged three times with nitrogen.     3-Butyn-1-ol     (14.87     g,     212.18     mmol)     and bis(triphenylphosphine)palladium(II) dichloride (2.98 g, 4.24 mmol) were added, and the resulting mixture was purged three times with nitrogen. The system was reacted at 40°C for 16 hours. The resulting reaction system was cooled to room temperature, concentrated, quenched with water, extracted with ethyl acetate (60 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated to obtain 325b (19 g, crude). MS m / z (ESI): 461 [M+1]+ Step 2: 325b (2.2 g, 4.78 mmol) was dissolved in tetrahydrofuran (100 mL), and methanol (100 mL) and Raney Ni (4.4 g) were added. The mixture was purged three times with hydrogen, and reacted at room temperature for 3 h. The reaction solution was filtered to remove insoluble materials. The filtrate was concentrated, and the residue was purified by silica gel column chromatography using eluent system B to obtain 325c (1.7 g, yield: 76.9%). MS m / z (ESI): 463 [M+1]+ Step 3: 325c (1.6 g, 3.46 mmol) was dissolved in dichloromethane (20 mL), triphenylphosphine (2.27 g, 8.65 mmol) was added, and the mixture was purged three times with nitrogen. Carbon tetrabromide (2.87 g, 8.65 mmol) was added under nitrogen atmosphere, and the resulting mixture was reacted at room temperature for 16 h. The reaction solution was concentrated to remove the solvent, and the residue was purified by silica gel column chromatography using eluent system B to obtain 325d (1.6 g, yield: 87.9%). MS m / z (ESI): 526 [M+1]+ Step 4: 325d (1.6 g, 2.86mmol) was dissolved in tetrahydrofuran (20 mL), N, N-diisopropylethylamine (738 mg, 5.71 mmol) and 6-(trifluoromethyl)-2,3-dihydrobenzofuran-3-amine (1.16 g, 5.71 mmol) were added, and the mixture was heated to 65°C and reacted for 48 h. The reaction solution was concentrated to remove the solvent, and the residue was purified by silica gel column chromatography using eluent B to obtain 325e (1.1 g, yield: 59.5%). MS m / z (ESI): 648.5 [M+1]+ Step 5: 325e (1.1 g, 1.70 mmol) was dissolved in tetrahydrofuran (10 mL), water (2 mL) and lithium hydroxide monohydrate (163 mg, 6.79 mmol) were added, and the mixture was reacted at room temperature for 16 h. The reaction solution was concentrated to remove the solvent, and the residual solution was adjusted to pH 56 with 1N HCl, extracted three times with ethyl acetate, and concentrated. The residue was purified by silica gel column chromatography using eluent B to obtain 325f (1.0 g, yield: 92.9%). MS m / z (ESI): 634 [M+1]+ Step 6: 325f (105 mg, 0.165 mmol) was dissolved in N, N-dimethylformamide (5 mL), N, N-diisopropylethylamine (107 mg, 0.828 mmol) and 2-(7-azabenzotriazol-1-yl)-N, N, N', N'-tetramethyluronium hexafluorophosphate (126 mg, 331 mmol) were added, and the mixture was reacted at room temperature for 16 h. The reaction solution was slowly added to water for quenching, extracted three times with ethyl acetate, and concentrated to obtain 325g (100 mg, yield: 98.0%). MS m / z (ESI): 616 [M+1]+ Step 7: 325g (100 mg, 0.162 mmol) was dissolved in trifluoroacetic acid (5 mL), and the mixture was heated to 80°C and reacted for 0.5 h. The reaction solution was concentrated, and the residue was purified by chromatography using eluent C to obtain Example 325 (38 mg, yield: 50.2%). MS m / z (ESI): 466 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.44 (d, 3H), 8.58-8.16 (m, 2H), 7.58 (d, 0.5H), 7.45 (d, 0.5H), 7.36-7.21 (m, 2H), 6.60 (t, 1H), 6.09 (d, 0.5H), 6.02-5.89 (m, 1H), 5.68 (dd, 0.5H), 4.88 (dt, 1H), 4.65 (m, 1H), 3.70 (d, 1H), 3.41 (dd, 0.5H), 3.12 (d,0.5H), 2.43-2.21 (m,1H). Example 331 4-Amino-10-((5-(trifluoromethyl)pyridin-2-yl)methyl)-9,10-dihydro-11H-azecino[4,3-g]imidazolo[1,5-a]quinoxalin-11-one Step 1: 5-(Trifluoromethyl)pyridine-2-carbaldehyde 331a (1.5 g, 8.57 mmol), 2-propyn-1-amine (471.81 mg, 8.57 mmol), sodium cyanoborohydride (1.61 g, 25.70 mmol), and acetic acid (102.88 mg, 1.71 mmol) were dissolved in methanol (20 mL), and the mixture was reacted at 20°C for 1 hour. The resulting reaction system was cooled to room temperature, concentrated, quenched with water, extracted with ethyl acetate (80 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated, to obtain crude 331b (1.69 g), which was used directly in the next step without purification. MS m / z (ESI): 215 [M+1]+ Step 2: 331b (1.69 g, 7.89 mmol), di-tert-butyl dicarbonate (3.44 g, 15.78 mmol), 4-dimethylaminopyridine (192.79 mg, 1.58 mmol), and triethylamine (2.40 g, 23.67 mmol) were dissolved in dichloromethane (20 mL), and the mixture was concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 331c (1.05 g, yield: 42.2%). MS m / z (ESI): 315 [M+1]+ Step 3:  62d  (320 mg, 0.68 mmol), N-((5-(trifluoromethyl)pyridin-2- yl)methyl)prop-2-yn-1-yl tert-butyloxycarbonyl carbonate (640.20 mg, 2.04 mmol), dichlorobis(tricyclohexylphosphine)palladium(II) (50.12 mg, 67.90 pmol), 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (64.73 mg, 135.79 pmol), and caesium carbonate (663.66 mg, 2.04 mmol) were dissolved in dioxane (6 mL), and the system was reacted at 100°C for 3 hours. The resulting reaction system was cooled to room temperature, concentrated, quenched with water, extracted with ethyl acetate (60 mL x 3), washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated to obtain 331d (180 mg, yield: 37.5%). MS m / z (ESI): 705 [M+1]+ Step 4: 331d (100 mg, 0.14 mmol) and Raney nickel (100 mg) were dissolved in methanol (10 mL) and tetrahydrofuran, and the mixture was purged three times with hydrogen, and reacted at 25°C under a hydrogen balloon for 0.5 hours. The resulting reaction system was filtered and concentrated to obtain 331e (0.1 g, crude). MS m / z (ESI): 707 [M+1]+ Step 5: 331e (0.1 g, 0.14 mmol) was dissolved in dichloromethane (2 mL) and trifluoroacetic acid (0.4 mL), and the system was reacted at 25°C for 0.5 hours, and concentrated to obtain 331f (100 mg, crude). MS m / z (ESI): 607 [M+1]+ Step 6: 331f (crude, 100 mg) and LiOH (10 mg, 0.42 mmol) were dissolved in methanol (2 mL), tetrahydrofuran (2 mL) and water (2 mL), and the reaction system was reacted at 50°C for 2 hours. The resulting reaction system was concentrated. The residue was purified by reversed-phase column chromatography using eluent system A to obtain 331g (22 mg, yield: 26.5%). MS m / z (ESI): 593 [M+1]+ Step 7: 331g (22 mg, 0.037 mmol) and 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (28 mg, 0.074 mmol) were dissolved in N,N-dimethylformamide (3 mL), N,N-diisopropylethylamine (14.3 mg, 8.76 mmol, 19 gL) was added, and the mixture was reacted at 25°C for 16 hours. The system was concentrated to dryness, and the residue was purified by silica gel column chromatography using eluent system C to obtain 331h (18 mg, yield: 84.6%). MS m / z (ESI): 575 [M+1]+ Step 8: 331h (18 mg, 0.031 mmol) was dissolved in trifluoroacetic acid (2 mL), and the mixture was purged three times with nitrogen. The reaction system was reacted at 90°C for 0.5 hours. The resulting reaction system was concentrated, and the residue was purified by silica gel column chromatography using eluent system A to obtain Example 331 (4.2 mg, yield: 31.9%). MS m / z (ESI): 425 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.24 (s, 1H), 8.96 - 8.94 (m, 1H), 8.62 (s, 1H), 8.22 (m, 1H), 7.93 (s, 1H), 7.59 - 7.54 (m, 3H), 7.37 (s, 1H), 6.97 (m, 1H), 6.41 (m, 1H), 4.96 (s, 2H), 3.85 (m, 2H). Example 352 (Z)-4-Amino-12-(1-(5-(trifluoromethyl)pyridin-2-yl)ethyl)-9,10,11,12- tetrahydro-13H-azo[4,3-g]imidazo[1,5-a]quinoxalin-13-one DM PM Referring to the synthesis method described in Step 6 to Step 9 of Example 62, Example 352 (32 mg, yield: 7.4%) was obtained from methyl (Z)-7-(5-bromopent-1-en-1-yl)-4-(3,5-dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 352a (500 mg, 0.93 mmol). MS m / z (ESI): 467 [M+1]+ 1H NMR (400 MHz, MeOD) 8 9.11-9.06 (m, 1H), 8.91-8.87 (m, 1H), 8.13 (dd, 1H), 8.07 (d, 1H), 8.01 (s, 1H), 7.79 (d, 1H), 7.30 (d, 1H), 6.56 (dd, 1H), 6.09 (dtd, 1H), 5.42 (dq, 1H), 3.76-3.68 (m, 1H), 3.62-3.49 (m, 1H), 2.16 (ddd, 1H), 1.86 (dd, 4H), 1.49 (dt, 2H). Example 362 (Z)-4-Amino-9-methyl-12-(2-(trifluoromethyl)-5,8-dihydro-6H-pyrano[3,4-b]pyridin-5-yl)-9,10,11,12-tetrahydro-13H-azo[4,3-g]imidazo[1,5- a]quinoxalin-13-one Step 1: 3-Methyltetrahydrofuran-2-one 362a (7 g, 69.92 mmol) was dissolved in dichloromethane (70 mL), and the mixture was purged three times with nitrogen. Diisobutylaluminium hydride (12.84 g, 90.90 mmol, 16.08 mL) was added dropwise at -78°C, and the reaction solution was stirred at -78°C for 1 hour. The reaction solution was added to a sodium tartrate solution, and the mixture was stirred for 2 hours. Water (500 ml) was added for phase separation, and the aqueous phase was extracted with tert-butyl methyl ether (500 ml). The organic phase was dried over anhydrous sodium sulphate, and concentrated at 20°C, and the intermediate was used directly in the next step. The intermediate was dissolved in methanol (70 mL), and dimethyl (1-diazo-2-oxopropyl)phosphonate (14.78 g, 76.91 mmol) and potassium carbonate (19.33 g, 139.84 mmol) were added at room temperature. The mixture was purged three times with nitrogen, and stirred overnight at room temperature. The reaction solution was filtered, the filtrate was mixed with silica gel powder, and the mixture was concentrated at 20°C for sample loading. The residue was subjected to column chromatography (PE : EA=62 : 38) to obtain 362b (3.8 g, 38.72 mmol, yield: 55.4%). Step 2: Methyl 7-bromo-4-[(2,4-dimethoxyphenyl)methylamino]imidazo[1,5-a]quinoxaline-8-carboxylate 362c (10 g, 21.22 mmol) and 362b (3.8 g, 38.72 mmol) were dissolved in DMF (100 mL), and bis(triphenylphosphine)palladium(II) dichloride (1.49 g, 2.12 mmol), cuprous iodide (808.18 mg, 4.24 mmol) and triethylamine (7.09 g, 70.02 mmol, 9.77 mL) were sequentially added at room temperature. The reaction solution was stirred overnight at 40°C. LCMS showed consumption of the starting material and formation of the product. Water (1 L) was added to the reaction solution, and the mixture was extracted three times with EA (300 mL). The organic phase was dried over anhydrous sodium sulphate, and concentrated, and the crude product was subjected to column chromatography (DCM : MeOH = 94 : 6) to obtain 362d (10 g, 20.47 mmol, yield: 96.5%). MS m / z (ESI): 489 [M+1]+ Step 3: 362d (10 g, 20.47 mmol) was dissolved in tetrahydrofuran (50 mL) and methanol (50 mL), Raney nickel (1.27 g, 21.57 mmol) was added at room temperature, and the mixture was purged three times with hydrogen. The reaction solution was stirred overnight at room temperature. LCMS showed consumption of the starting material and formation of the product. The reaction solution was directly filtered by suction, and the filtrate was concentrated to obtain crude 362e, which was used directly in the next step. MS m / z (ESI): 491 [M+1]+ Step 4: 362e was dissolved in dichloromethane (10 mL), carbon tetrabromide (2.89 g, 8.72 mmol) and triphenylphosphine (2.29 g, 8.72 mmol) were sequentially added at room temperature, and the reaction solution was stirred for 2 hours. LCMS showed consumption of the starting material and formation of the product. Water (100 ml) was added to the reaction solution, and the mixture was extracted three times with ethyl acetate (30 ml). The organic phase was dried over anhydrous sodium sulphate, and concentrated, and the crude product was subjected to column chromatography (DCM : MeOH = 94 : 6) to obtain 362f (1.1 g, 2.11 mmol, two-step yield: 96.7%). MS m / z (ESI): 553 [M+1]+ Step 5: 362f (3 g, 5.75 mmol) was dissolved in acetonitrile (10 mL), potassium carbonate (2.39 g, 17.26 mmol) and sodium iodide (862.37 mg, 5.75 mmol) were added at room temperature, and the mixture was purged three times with nitrogen. The reaction solution was stirred overnight at 80°C. LCMS showed consumption of the starting material and formation of the product. Water (100 ml) was added to the reaction solution, and the mixture was extracted three times with ethyl acetate (30 ml). The organic phase was dried over anhydrous sodium sulphate, and concentrated, and the crude product was subjected to column chromatography (DCM : MeOH = 95 : 5) to obtain 362g (2 g, 3.03 mmol, yield: 52.8%). MS m / z (ESI): 691 [M+1]+ Step 6: 362g (500 mg, 759.06 pmol) was dissolved in water (2 mL), tetrahydrofuran (2 mL) and methanol (2 mL), and lithium hydroxide (18.18 mg, 759.06 pmol) was added at room temperature. The reaction solution was stirred overnight at room temperature. LCMS showed consumption of the starting material and formation of the product. The reaction solution was adjusted to pH 5-6 with dilute hydrochloric acid, and extracted with ethyl acetate. The organic phase was dried and concentrated to obtain crude 362h (460 mg), which was used directly in the next step. MS m / z (ESI): 677 [M+1]+ Step 7: 362h (600 mg, 930.69 umol) was dissolved in N,N-dimethylformamide (10         mL),         (7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (702.24 mg, 1.86 mmol) was added at room temperature, and the mixture was purged three times with nitrogen. The reaction solution was stirred at room temperature for 24 hours. LCMS showed consumption of the starting material and formation of the product. Water (200 ml) was added to the reaction solution, and the mixture was extracted three times with ethyl acetate (100 ml). The organic phase was washed with a sodium chloride aqueous solution, dried over anhydrous sodium sulphate, and concentrated, and the crude product was subjected to column chromatography (DCM : MeOH = 95 : 5) to obtain 362i (320 mg, 510.64 amol, yield: 54.9%). MS m / z (ESI): 659 [M+1]+ Step 8: 362i (300 mg, 478.72 pmol) was dissolved in trifluoroacetic acid (8 mL), and the mixture was purged three times with nitrogen. The reaction solution was stirred at 90°C for 0.5 hours. LCMS showed consumption of the starting material and formation of the product. The reaction solution was added to ice water, adjusted to weakly alkaline pH with sodium bicarbonate, and extracted with ethyl acetate, and the organic phase was concentrated. The crude product was subjected to basic preparative chromatography to obtain Example 362 (30 mg, yield: 12.3%). MS m / z (ESI): 509 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 6 9.17 (s, 1H), 8.13 (m, 2H), 8.04 (br s, 1H), 7.85 (t, 2H), 7.18 (m, 2H), 6.48 (dd, 1H), 5.53 (m, 1H), 4.82 (m, 2H), 4.22 (m, 2H), 3.77 (m, 1H), 3.55 (m, 2H), 1.23 (m, 3H), 0.97 (d, 1H), 0.85 (d, 2H). Example 374 4-Amino-12-(1-(5-(trifluoromethyl)pyridin-2-yl)ethyl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazonino[8,7-g]quinoxalin-13(7H)-one Step 1: 2-Acetyl-5-(trifluoromethyl)pyridine 374a (5 g, 26.44 mmol) was dissolved in ethanol (100 mL), hydroxylamine hydrochloride (3.67 g, 52.87 mmol) and sodium acetate (8.67 g, 405.74 mmol) were added, and the mixture was stirred and reacted at 80°C for about 3 hours. Water (200 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (200 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 374b (4.8 g, yield: 88.9%). MS m / z (ESI): 205 [M+1]+ Step 2: 374b (4.7 g, 23.02 mmol) was dissolved in trifluoroacetic acid (60 mL), zinc powder (7.5 g, 115.11 mmol) was added, and the mixture was heated and reacted at 80°C for 3 hours. The reaction solution was filtered, distilled under reduced pressure, adjusted to alkaline pH with a saturated sodium hydroxide solution, and extracted with dichloromethane (2 x100 ml). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 374c (1.9 g, yield: 43.4%). MS m / z (ESI): 595 [M+1]+ Referring to the method described in Step 5 to Step 8 of Example 14, Example 374 (2 mg, yield: 1.2%) was obtained from 374c (70 mg, 0.36 mmol). MS m / z (ESI): 471 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.37 (s, 1H), 8.96 - 8.92 (m, 1H), 8.23 (d, 2H), 8.17 (d, 1H), 7.94 (dd, 1H), 7.48 (d, 1H), 5.55 (d, 1H), 4.75 (dd, 1H), 4.52 -4.46 (m,1H), 3.85 - 3.69 (m, 1H), 3.22 - 3.06 (m,4H), 1.87 (d, 2H), 1.77 (d, 2H). Example 391 (Z)-4-Amino-12-(6-(trifluoromethyl)pyridazin-3-yl)methyl-9,10,11,12-tetrahydro-13H-azonino[4,3-g]imidazo[1,5-a]quinoxalin-13-one Referring to the synthesis method described in Step 6 to Step 9 of Example 62, Example 391 (9 mg, yield: 2.5%) was obtained from methyl (Z)-7-(6-bromopent-1-en-1-yl)-4-(2,4-dimethoxybenzylamino)imidazo[1,5-a]quinoxaline-8-carboxylate 62g (422 mg, 0.78 mmol). MS m / z (ESI): 454 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.22 (s, 1H), 8.31 (d, 1H), 8.25 (s, 1H), 8.10 (s, 1H), 8.05 (d, 1H), 7.26 (s, 1H), 6.53 (d, 1H), 5.98 (td, 1H), 5.15 (d, 1H), 4.87 (d, 1H), 3.48 (m, 2H), 2.13 (dt, 1H), 1.75 (m, 2H), 1.43 (d, 1H). Example 414 4-Ammo-12-((5-(pentafluoro-Z6-sulphanyl)pyridin-2-yl)methyl)-9,10,11,12-tetrahydroimidazo[1,5-a][1,5]oxazonino[8,7-g]quinoxalin-13(7H)-one 414c Step 1: 5-Sulphanyl-2-cyanopyridine 414a (10.00 g, 73.53 mmol) and sodium iodide (4.47 g, 30.00 mmol) were dispersed in acetonitrile (200 mL), ferric chloride (4.83 g, 30.00 mmol) was added at 25°C, and the mixture was stirred and reacted at 25°C for 16 hours. The reaction solution was diluted with dichloromethane (200 mL), and filtered to remove insoluble materials. The filtrate was concentrated under reduced pressure to dryness, and the resulting residue was purified by silica gel column chromatography using eluent system A to obtain 414b (6.15 g, yield: 62.0%). MS m / z (ESI): 271 [M+1]+ Step 2: 414b (6.15 g, 22.78 mmol) and tetraethylammonium chloride (7.52 g, 45.56 mmol) were dispersed in acetonitrile (150 mL), and silver difluoride (52.85 g, 364.48 mmol) was added. The mixture was stirred and reacted at 25°C for 16 hours. The reaction solution was filtered to remove insoluble materials. The filtrate was concentrated under reduced pressure to dryness, and the resulting residue was purified by silica gel column chromatography using eluent system A to obtain 414c (1.57 g, yield: 15.0%). MS m / z (ESI): 231 [M+1]+ Step 3: 414c (1.57 g, 6.83 mmol), di-tert-butyl dicarbonate (2.83 g, 13.00 mmol) and cobalt chloride (1.07 g, 8.20 mmol) were dispersed in methanol (30 mL), sodium borohydride (1.82 g, 47.81 mmol) was added in portions at 0°C, and the mixture was stirred and reacted at 25°C for 1 hour. Water (2 mL) and dichloromethane (50 mL) were added to the reaction solution, and the mixture was filtered to remove insoluble materials. The filtrate was concentrated under reduced pressure to dryness, and the resulting residue was purified by silica gel column chromatography using eluent system A to obtain 414d (1.65 g, yield: 72.5%). MS m / z (ESI): 335 [M+1]+ Step 4: 414d (1.65 g, 4.94 mmol) was dispersed in hydrochloric acid (20 mL, 4 M, 1,4-dioxane solution). The mixture was stirred and reacted at 25°C for 2 hours. The reaction solution was concentrated under reduced pressure to dryness to obtain 414e (1.10 g, yield: 95.5%). MS m / z (ESI): 235 [M+1]+ Referring to the method described in Step 5 to Step 8 of Example 14, Example 414 (29 mg, yield: 3.8%) was obtained from 414e (350 mg, 1.50 mmol). MS m / z (ESI): 515 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.22 (s, 1H), 9.13 (s, 1H), 8.39 (dd, 1H), 8.10 (s, 1H), 7.99 - 7.38 (m, 5H), 5.18 (d, 1H), 4.71 - 4.40 (m, 3H), 3.80 (d, 1H), 3.48 (dd, 3H), 1.92 (d, 1H), 1.26 (d, 1H). Example 415 (Z)-4-Amino-12-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-9,10,11,12-tetrahydro-13H-azo[4,3-g]imidazo[1,5-a]quinoxalin-13-one Referring to the synthesis method described in Step 6 to Step 9 of Example 62, Example 415 (28 mg, yield: 6.5%) was obtained from methyl (Z)-7-(5-bromopent-1-en-1-yl)-4-(3,5-dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 415a (500 mg, 0.93 mmol). MS m / z (ESI): 467 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.24 (d, 1H), 8.86 (s, 1H), 8.21-8.12 (m, 2H), 8.09-7.89 (m, 3H), 7.21 (s, 1H), 6.54 (t, 1H), 6.18-5.92 (m, 1H), 5.37 (dd, 1H), 3.55 (d, 2H), 2.14 (t, 1H), 2.03 (d, 1H), 1.77 (dd, 4H), 1.48 (s, 1H), 1.34 (s, 1H). Example 416 (Z)-4-Amino-11-(5-(trifluoromethyl)pyridin-2-yl)methyl-10,11-dihydroazocino[4,3-g]imidazo[1,5-a]quinoxalin-12(9H)-one Referring to the method described in Step 9 of Example 62, Example 416 (28 mg, yield: 63.8%) was obtained from (Z)-4-(2,4-dimethoxybenzylamino)-1-(5-(trifluoromethyl)pyridin-2-yl)methyl-10,11-dihydroazocino[4,3-g]imidazo[1,5-a]quinoxalin-12(9H)-one 250c (60 mg, 0.10 mmol). MS m / z (ESI): 439 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.31 (s, 1H), 8.96 (d, 1H), 8.27 (s, 1H), 8.26 (broad s, 2H), 8.24 (dd, 1H), 8.11 (s, 1H), 7.64 (d, 1H), 7.26 (s, 1H), 6.59 (d, 1H), 5.86 - 5.77 (m, 1H), 5.11 (d, 1H), 4.65 (d, 1H), 3.87 (t, 1H), 2.70 (td, 1H), 2.38 (dt, 1H) Example 417 4-Amino-13-((5-(trifluoromethyl)pyridin-2-yl)methyl)-10,11,12,13-tetrahydro- 7H-imidazo[1,5-a][1,6]oxazino[3,4-g]quinoxalin-14(9H)-one Referring to the method described in Step 6 to Step 9 of Example 62, Example 417 (7 mg, yield: 1.6%) was obtained from methyl 7-((3-bromopropoxy)methyl)-4-((2,4-dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 417a (500 mg, 0.89 mmol). MS m / z (ESI): 471 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.39 (s, 1H), 9.01 (s, 1H), 8.90 (broad s, 2H), 8.33 - 8.22 (m, 2H), 8.19 (s, 1H), 7.81 (d, J = 8.3 Hz, 1H), 7.52 (s, 1H), 5.26 (d, 1H), 4.75 (d, 1H), 4.48 (t, 1H), 4.40 (d, 1H), 3.66 (t, 2H), 3.22 (d, 2H), 2.04 - 1.61 (m, 4H) Example 418 (Z)-4-Amino-12-(6-(trifluoromethyl)pyridazin-3-yl)methyl-9,10,11,12- tetrahydro-13H-azocino[4,3-g]imidazo[1,5-a]quinoxalin-13-one Referring to the synthesis method described in Step 6 to Step 9 of Example 62, Example 418 (3.7 mg, yield: 1.5%) was obtained from methyl (Z)-7-(6-bromobut-1-en-1-yl)-4-(2,4-dimethoxybenzylamino)imidazo[1,5-a]quinoxaline-8-carboxylate 418a (300 mg, 0.57 mmol). MS m / z (ESI): 440 [M+1]+ 1H NMR (400 MHz, MeOD) 5 9.09 (s, 1H), 8.19 (s, 1H), 8.15 (d, 1H), 8.06 (m, 2H), 7.32 (s, 1H), 6.61 (d, 1H), 5.90 (dd, 1H), 5.37 (d, 1H), 4.93 (d, 1H), 4.07 (t, 1H), 3.50 (s, 1H), 2.85 (dd, 1H), 2.50 (d, 1H). Example 419 (Z)-4-Amino-12-(3',5'-difluoro-[3,4'-bipyridin]-6-yl)methyl-9,10,11,12- tetrahydro-13H-azonino[4,3-g]imidazo[1,5-a]quinoxalin-13-one 4l9a                 419b Step 1: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrile 419a (5.73 g, 24.90 mmol), 3,5-difluoro-4-iodopyridine 419b (5 g, 20.75 mmol), Pd(dppf)Cl2 (1.52 g, 2.08 mmol), and K2CO3 (5.74 g, 41.50 mmol) were dissolved in water (50 mL) and 1,4-dioxane (10 mL), and the mixture was stirred and reacted at 100°C for 12 hours. The system was cooled, quenched under atmospheric pressure, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography using eluent system A to obtain 419c (3 g, yield: 77.7%). MS m / z (ESI): 218 [M+1]+ Step 2: 419c (2.91 g, 13.40 mmol) was dissolved in THF (40 mL), 2M LiAlH4 / THF solution (8 mL) was added at 0°C, and the mixture was stirred and reacted at 20°C for 3 hours. The system was quenched with a saturated ammonium chloride solution, and concentrated under reduced pressure, and the resulting residue was purified by reversed-phase chromatography using eluent system D to obtain 419d (2.15 g, yield: 72.5%). MS m / z (ESI): 222 [M+1]+ Referring to the synthesis method described in Step 6 to Step 9 of Example 62, Example 419 (5.6 mg, yield: 2.5%) was obtained from 419d and methyl (Z)-7-(6-bromohex-1-en-1-yl)-4-(2,4-dimethoxybenzylamino)imidazo[1,5-a]quinoxaline-8-carboxylate 62g (270 mg, 0.50 mmol). MS m / z (ESI): 498 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.17 (s, 1H), 8.77 (d, 1H), 8.73 (s, 2H), 8.22 (s, 1H), 8.11 (m, 1H), 7.90 (s, 1H), 7.66 (d, 1H), 7.39 (s, 2H), 7.19 (s, 1H), 6.54 (d, 1H), 6.00 (m, 1H), 5.06 (d, 1H), 4.47 (d, 1H), 3.43 (d, 2H), 2.12 (m, 1H), 1.79 (dq, 2H), 1.41 (d, 1H). 5        The following examples were prepared by reference to Example 14: Example Structure MS m / z (ESI) [M+1]+ Example Structure MS m / z (ESI) [M+1]+ 420 H,N \ Zn N Y y CK      rr / —V O     N 491 520-P2 H2N \ Z^N 4 \ 0 N N-^ /   \          SFs o Lz^ 597 421 H,N JI N 2—\^° 1^11^ 475 521 "AXo H zz 517 422 H,N zZN NZ W ^CF} ir°O 469 521-P1 H,N V ) ( ° F— O x~Xf 517 423 St? U * XjCC <> z z    \_ '—o X 483 521-P2 H,N    k \ z° f~Y3 o ryN 517 424 .o^ ® C3X / O / 2-2 z 05 <j\ 529 522 H2NW-o / \         sf5 1      \ V- N o    n^y'-Y 559 425 in & ZM. z-zz o / Mi z 529 523 ^vAo MM Am' O N A \ ^-o 573 426 H,N \ / X /  \         SF, W MV \ / N— 528 523-P1 H,N V / \      SF, W ,W <Y° WN \-~O 573 427 515 523-P2 H,N Z l=\       SF< rY°O ^-o 573 428 Z^'Z 2            / T ^^--..^-2 516 524 F H?N L W H / Y°O o nVA ^-o 577 429 n ® CM / O Z-2 VZ Q 2 J / JM 547 524-P1 F H,N    1 2 \ Z^o <A\       SFs rXo<L^ °   N“x\ Z Mo 577 430 "!Vo / p O ^vCF3 fr°O 471 524-P2 F H,N Z / \      SFs W zzf fy° vJn °   Nfcz\ '"O 577 431 "Z Mo 503 525 F H2N k 2 \ z^o 4 -7 <r°zy ■ O Mo 562 432 504 525-P1 F H2N 1 \ < ° / V 4 /          SF, / / ° £Y O Vo 562 433 H2N 2 \ / () ,o 535 525-P2 F H2N     / \ / ° ^) / W  ^\^SF5 <Y° £Y °   k- / / ^ / ---7 / o 562 434 HAVo / \          sf5 w o  n^n 517 526 F H,N    V \ < ° Nv / ^ SF, W zY <7^° \ 7 O    N—Z~N 535 435-P1 H2\Xo 517 526-P1 F H2N L \ / ° / \      SF, / /  Z~ / r^V° \ / o LV 535 436 n^Xo O    N— / 518 526-P2 F H,Vo --' SF, o LV 535 437-P1 H2vK /   \          SF, w \ / 531 527 Cl h2n L \ / ° NvV^ / \      SF5 VV / ) ^-o 593 438 u / z O-,       °\    / •^4 Y / ~z jOO. z z    \—f< rq                    D X 485 527-P1 Cl H2V?"o / \      SFs W zi <Y°O O   N^ / \ O 593 439 -aX, ' v m Qd v 549 527-P2 Q h2n k / \      SF, M-ct ■ Vo 593 440 H,N    ~ \ d "' NZ O M    Jj \__ /      N 501 528 Cl h2n k \ r ° N\— X /   ^^=SF5 <y°£T ' o V-o 578 441 h2n 2 \ Xx H j N N"^ । । ° O^_ / N^b^b o 470 528-P1 Cl H,N k \ < ° 4 d ^\^SFs rx° CT V-o 578 442 ID to 2=, O XOJ 2 0 S 528 528-P2 Cl H2^    L \ < ° \ /           ,sf5 cc° ct ' O —d V-o 578 443 H2N MX N N^ 543 529 Cl H!vJ-o xV / V      SF, W xx< o LbN 551 444 H2N 2 v^N C\ J N N^ H / \^° ,M 0        J \__ /      N 425 529-P1 Cl Cv / V      sf5 V-x~^N 551 445 ? yx 490 529-P2 Cl HA, / " / \      SF, W / XX ' yy^0 \ > o L / =n 551 446 X •'J yy <v„ 489 530 HZN\ X?' 515 447 X roa ( o ^-o M -u5 521 530-P1 z^,      O / 515 448 H^o yy / ^ / cr3 yr°y x^ 487 530-P2 H,N ^)yJ F~~f3 6 k / "N 515 449 H,N \ / ° XjV^ \ / /      _ sf5 rr°r^ ‘ o.___ Z) 545 531 h2n F—X"X w x~y\ o ly^ 517 450 . yy ° v} <Z> 530 531-P1 H2N     z. ) ( ° \yyi F~~yy W x~x / \ o 517 451 Q ^Xo o—, o / xC CM 'w' X 472 531-P2 h2n \ < ° r~~O 517 452 S ( o n X 427 532 HA / ^N 529 453 yy\ O ^VCF’ / \^O V I          p \ N ^() 499 532-P1 H,N 2 \ / ^N K x F^f) 529 454 nL / ^ O ^sFs 1    1 K / N O__ S) 557 532-P2 z-zz Q / 529 455 H2Vz^ yy W / CF i r £ F o__ ^-o 484 533 H,N N   N-^ y) o^ y© f /  ^-N    / =x   / =\ F 515 456 uT !Z) z-z ® 7x0 CM X 542 534 H2\Z"o Ny^y y) yo f / z—n / =\ y=\ F 517 457 / ° / ~z o\ 2       /      -fl VS 502 535 "2NW^n y yo f / z-n / =\ y=\ F 529 458 X 7»X / c / ~z J JXS n 533 536 H2N \ / ^N )r\ j N N"^ / -7' 529 459 a: \ ° / Z~z c *5 439 536-P1 HiN\ Z^N Mj / Vz " 529 460 a: Qox / o / X \z=C ZH \z=2 462 536-P2 H,N \ Mj ..-z 529 461 HO Co <\_ / xAn 461 537 h2n N^Oy-Z /  \         SF, W / T< o LXn 531 462 s qox / o O = X5 493 537-P1 H,N \ < ° NvV— /  \         SF5 w o LXn 531 463 H,M X OrTO O_ / NKy^Z '<> 459 537-P2 ":V» /   \          SF. W o LXn 531 464 H2N / Cj> VC / \ / sfs Cy°xx Ox_zNk^X / N 517 538 h2n \ < N CjX /  \         SF, c> LXn 543 465 HZN / Cc \\° O\_^*^0^0 / O 444 538-P1 H2N 2 \   / ^N CCo /   \          SF, W zzf 543 466 R. rTfR o 502 538-P2 h2n Ny-^ /   \          SF, R ri r / r \ ? O     N-_ / 543 467 :R / o n^x X / n ■55 417 539 HRN nRj R )=o /    / —N   / =\ X--- / / SFs N-^ 529 468 H2N / Nvv R / / \ / SF5 rrt 475 540 "2W<> R) ()- / )=o /    / —N / =\ / >-sf5 N—' 531 469 "M 475 541 HR" RR R qR Ro /    / —N / =\ M _R5 543 470 HR 476 542 H,N \ RN n / R / /  \         CF, W .ri / IRn 485 471 CX F o n JTI 458 542-P1 h2n \ Rn Ma HR 485 472 H"W w / R°0 o nR \ o 473 542-P2 HRn n / H' / I \          CF, W ri ir° \ / q^^n~ / ~~n 485 473 H2N     / /   \          SF5 kJ w /      y^N O ^~O 531 543 HA / ^n /  \         CF, W r^V° \ O   K-V^ 499 474 H2N     / Nw C /          SF; <r° (y o    x.y''y 516 543-P1 h2n ~ / ^N / yxx /  \         CF, W o Ly 499 475 h2n Z 475 543-P2 H,N \ < N vV /  \         CF, W z^Y \ / 0    N— / 5 499 476 h2n 2 yA )r \ j N y 471 544 H2Vn / yy /  \         ,CF3 / ry 485 477 h2n \ zz N F \ J N   N-^ y 529 545 H,N \ < N / jy /  \        CF, w \ y y> ~^N 485 478 h2n J] N y 471 546 /      U ^7“z = (    L# y-z ^Z-Zs / =( ,2 J °^Z. j Y z 475 479 H2N 2 y / ^N H j N A-c 529 547 "'M A;? 475 480 'A Ao /  \        CF, W A AyO \ B— O    N— / N 473 548 H,N z^ \ AN 4 \ J N A-' 413 481 H2NV^o / A>       SF5 / —y° O     N-— / N 531 549 H2N \ < ° Ny-Z M / W / A AA^° / v> oy^jAN 415 482 nA^A /  \         CF, w Ay0 \ A 473 550 ,0-, ® Qxx / O zZ~Z z J 427 483 "^'A aa ZA>       sfs z— 531 551 H2N z^ \ .AN H j N N-^ / •ft-? 427 484 H,N   — \ An A j N  N^ <AA» / =\ A A>A 455 552 "2XW<> M / W zA o LAn 429 485 “Ban A\ W A Ar AN O   N^ / \ B O 513 553 h2n - vZN A A AA 441 486 H2N \ AN A\ J N N-^ y) ^AQ4P 459 554 H2N    z^ \ An A \ J N N-^ "W / rr / °y^yN—7 350 487 H2N \ . / / N AV )M o- / >o _j\P X---- / 471 555 H2N \ x° vJ* / <Y°X O    N—7 352 488 h2n W^N / y-Nx OA>o Y>Yo 485 556 h2n \ N Nfy\ W / <Y° / O    N-A 364 489 H2N \ / AN X J N N^ X o-^>o 1 ^N    / =\ A YV F N—7   v 473 557 H2V / "o W xCF3 o    y— / 448 490 :....... -\ n -71 z 482 558 H2N    z. \ / AN X J N N"^ <—\y° ri\ O     N-- / 378 491 H2N \ / AN X J N N^ Pep" Y_Y    cn 481 559 h2n \ < ° Cv Y> YA O    N— / 380 492 H2N \ Xn X J N N^ A-':.. 482 560 "2Vy^ XA VA p—\a° ya O    N^ / 392 493 h2n \ / ^N X J N N^ -A<r 470 561 H2N \ X j N   N-^ VY     CF3 Y° / o   nX 404 494 H2N \ < N NV\ ^Xo p / CF’ 470 562 ^Az-o 4 P      CF, <Y° / °A_^ / N—7 406 494-P1 H>N AvZ A>      CF AzXT 3 470 563 “2Vn / jA 4 -7        CF3 rx° / O     N-~Z 418 494-P2 h2n \ f N AvZ <r ° aa3 470 564 H2V / ^n nQ-A /  \        CF, W zZ A LAn 497 495 h2n / A / \          / CF3 w zz zz° \ a 0 LA 485 565 H?N \ / ^° C / /   \         CF, W zZ ZA^0 \ ? A 485 496 h2n \ / A / r\ j N ?A 471 566 “Z Z'N Z^ J N N"^ A°sf 528 497 H2N \ / N LAZ /  \         CF, -4 LA 483 567 H,N \ / Z N A \ J N z^\.° rA\ — N     N-- / / 391 497-P1 "2NvZn ZAz A zZ -7 Izn 483 568 H,N \ -z N A \ J N N-^ — N    N-Z 409 497-P2 H2N \ / ^N AA A zZ ZZ°\ \\ /    £ Zn U"A     N-—7 483 569 H2N \ A^n z \ J N   N-^ —N    N-V 459 498 H,N \ Z N \ J N   N >4 o-- / >o /     N / =\   / \ J^AZ CF3 v 523 570 h2n \ / Z N z \ J N N-^ M —n^^n-A 405 499 Zj-A A* o-ARo N / =\ / \ 469 571 H,N \ U N H j N N ? V-• 468 500 H2N \ An / a< y) o-^>o ; z—n     / =\    a N^ V 487 572 H2N 2 \   / ^N FK J     F 486 501 h2n - Au X o-Xo N / =\ A Ry—Me N— / 483 573 h2n \ ,X^N / r\ j       cf3 A". 536 502 Au / jA W H ' Ryo \ 7 --n^^n.-Y'N 483 574 h2n \ Xn 4 \ 0 Me H X Ax 482 503 C ° / z~z X •J? 460 575 H2N \ / AN / XX J N   N-^ —N    N— / 363 504 h2n \ A N A \ J N N^ Py^"' o^^n—7 446 576 H,N vUN AA j VA     ,cf3 A° / —N     N~— / 417 505 _O^        * / O     ^-2 2     / n 489 577 "2N. / <• Xy-A / \          sf, W uR ’ " uu ~^N 530 506 Cl AjA /  \         ,CF, W AA> \ 2 o LAn 505 578 H,N \ < ° NVa^ v) A—A^o Al —-N     N-A 393 507 h2n zZj N Ac" 470 579 "^vA-o Q J A^aa° VJ\ -—N     N--A^ 411 508 H2Az-o N^A I \          CF, W / A Av \ ? —N    N-Z N 471 580 “'Az-o NvV^ Q vCF3 — N   N-V^ 461 509 'C / o Al—1 A) o^A /    N    / =\   A A AAf N—'   v 475 581 ^VZ-O VA O A16 —-N     N— / 407 510 o-^Ao A^N / =\ A 457 582 H2NVZ"O naA W zA^ AA^° \ / — N nA^~N 470 511 H,N \ < o n^AA o-Ao / =\ A \ y    —AA- Me N— / A 471 583 H2N 488 512 "Z / o Al—1 (A oA A° M AAACFj V 525 584 538 513 H2N \ / z N )r\ j N o— yO / —N / =\ / XCF3 471 585 h2n 484 514 H2N \ N O    / x CFi ?—\,O ||| 469 586 H2NW^o / y / rr°X — N    N— / 365 514-P1 H2N 2 \ An N VA      CF >^\.O A / 3 1       > A- > 469 587 H,N \ < ° \* /        cf3 rr°Z _-N     N—7 419 514-P2 H2N \ V \ JJ N N-^ Axr ..... 469 588 H2V / ^n / jA / \         sf5 / \y \ y —N    N-Z N 542 515 H2N M.O o Hy^ 503 589 H2NvZ-o \-J < —\^° Ch —-N      N--> / 393 516 H,N / V _ /  \ F— / / \ W / —v>° \  y F o 515 590 H2V^"o W V -—n      N~~y 411 517 h2n \ / r\ j N N-^ j5^"' 485 591 H,N \ / ^N ZjA Q / cF’ rj\ —-N    N— / 473 517-P1 h2n \ , / ^N 4 \ J N N-^ ■%.-" 485 592 h2n \ AA J N   N-^ A. / -7 405 517-P2 h2n \ / / N / / \ JI N N*^ A-- / 485 593 h2n N N 468 518 h2n \ A N 4 \ J N N*^ O           * f3c--~A''^ 539 594 H2N J / a<A —N N- / 486 518-P1 H2N \ / / N A \ J N N*^ 0    N-V 539 595 h2n W J cf3 A,' —N N- / " 536 518-P2 H»N ZA" o n-v !> FjC^^ 539 596 H2N \ / AN A \ IJ            Me 482 519 h2n \ / / N j N N^ A- / 543 597 H,N 2 \   / ^N / r\ j N N-^ Pry —N    N-V 363 519-P1 H2N    ~ \   / / N J N / ■ / " O    N—A 543 598 H,N AA j VA     cf3 AY° / —N     N~- / 417 519-P2 h2n \ / / N A \ JJ N A- / ' 543 599 K2N    . \__zA N nZ nA 501 520 H2N \ / / N 4 \ J N   N*^ - / o     N-~y FaC-^A^7 597 599-P1 H2N    z\ Y—^A N nz nA .A' / .'" 501 520-P1 H,N \ / z N J N JrA 597 599-P2 H2N     / x \__ / / N nz n-^ .. J'," \' 501 The following examples were prepared by reference to Example 62: Example Structure MS m / z (ESI) [M+1]+ Example Structure MS m / z (ESI) [M+1]+ 600 h2n r\ j N M F\ F w / —\y° \  7 V                   \ '\ /    Cl 454 664 "2W'<> \> /           cf3 l nfAn ^°z \ j 485 601 h2n \ J N F\     F \      /        F 438 665 H1NW^o \ / /            sf5 / r°r^ J J ^c> 543 602 H,N / \ J N / \    F ( TX 427 666 X Ocxx \ / r^\ ° ° \ 3 q 470 603 '-V- CF, Z / ' V    N^ / A Vy 521 667 <r, (Z) O-.      o YXX ? z z X 528 604 X ( kAA / Z-Z 2 / : / 511 668 X OCXX z^<      \ / o      ^-o t / y \=2 488 605 s ( aXa T ° az ”1 2             / 512 669 H2Va° Ma 487 606 "2V^ AA-A / \     CF, KoA ' / / V J= / N v_d Vo2 511 670 (A 0 x / °A ° / YiX; Z Z \^_ / £ 519 607 "Az N\Z / /  \         SF, W / A 524 671 H,N \ < ° Cz \ / /         / F2H fr fj o 425 608 "A-o N^y-J / \        cf3 W OA< ' fx / A C    n-A A " -    A Q / 509 672 "A 458 609 A 0^’ X Ti A x     V K 494 673 "A 457 610 H2V^o )=( F^) 500 674 "A ; fez 489 611 h2n \ A ° nO^ r^T3 499 675 "A o Yz ^ / CF.-> QA 455 612 h2n X 2 \ / ^o XX F-zy yXoyiX-^JLX 513 676 H2N / Nw ^ / SF5 Ka 513 613 H2yX° yX FX> yXoyXf-^JXXN 514 677 H2N     / NvV 4a Zy° AycF3 o 440 614 H,N / ( ° X CIXA XX XX^21 LXn 531 678 H2N     / Nw Ay0 r^ySF5 K-o 498 615 "2Xo NWJ /  \         CF3 KofV / / v X<N V     N-— / A --------^      V_ Q / 523 679 X Z=\^^Z 2 I XXX 4 x° X / n 413 616 tT u ^Xo Pa    C zA^Xy X     — 508 680 X Z^\ A\ z. 2 ( XXX 4 '° M 05 VI 471 617 H2N L 2 \ / ^o XX ciy^A X,o (X':| X^n 545 681 H2N / Nw \ / /          xCF2H fX°fT 395 618 HA / -o N^Ay /  \         ZCF3 w \   N->N 457 682 "iNH Ay 472 619 "Zo /  \        CF, W ( LZn 471 683 ",NH 471 620 H2N \      N r \ JJ N \ /          sf5 fr°£T 497 684 H2N     / / \         cf3 ^r°O 469 621 H,N    ~ N &?■ 539 685 n 454 622 H,N    ~ \      N J N X /     _ CHI, jrfj _ZN^ 421 686 H2N / Nvx / \         sf5 C   N^ / \ Z<) 527 623 LOCI’ <! o ^-z M o / n Tl 1 437 687 H2N     / nH L y     / ^SFs fr\Q V    N—Z V-o 512 624 H2N J N 3»...... 455 688 H,N \ Z^N X \ J N N-^ \ L         cf3 frfX 453 625 h2n \ / ^N H j N N-^ pC'fi" 482 689 H,N 2 \ Z^N / M j N ^OL” 511 626 H,N j N /      _ zcf3 fr fl 0—1 467 690 H2N vAN r \ JI N N"^ CF, w \ K~ n-V~~n 467 627 h2n 2 \       N H j N 5".r 440 691 H,N     z.. \ X N r \ j N   N"^ SFS z—y° ( /     N~ / N 525 628 H,N 2 \   / ^N 4 \ J N [ji ° / YCF’ 438 692 C XXX ZX\      \^ / o      '-o 55 1 5 455 629 H2N )r \ jj N \ /     _ SF, fr°0 ' 496 693 / & °~A      °   / X / X ' / ^ XXX J Z Z   \=Z £ 513 630 n^y^o 486 694 H2Vv^o NWJ AA _cf, / —v° rv N— / N 469 631 “V XV 485 695 "!V'o /  \         SF, W / 5 527 632 hAa> Xp o 517 696 H2\_Z-n .A.'" 453 633 "2W'o Z /       .. .cf3 Lvy 483 696-P1 H2N\ Z"n NZ N"^ Z-Z 453 634 H2NW^o vV Z /      _ .SFs rvcc ’ L^nyV 541 696-P2 H2\ N rj z?'" 453 635 h’nvA> iCC-O Z V° Z\_-cf3 ^-0 468 697 u V-b Z-ZZ    0 / ---- A’Z X 467 636 HzN\ Z o W bi °rnrSF5 ^-0 526 697-P1 X OOOz ■Az / Z~Z 2 J 467 637 X / =\      2 c xxz 2— / o      '-o M 499 697-P2 cob >>‘‘b 0 cX 2 / 467 638 X / =\      2 c xxz / o     ^-o b n 441 698 X ( jCCX 2-Z\        \    / ! ° =¾ Q 482 639 H1Vo vz^ \ /        xcf2h (r°fl 423 699 X C^X / Z-. ,z~. 2 ( XXh /   0 / TO 2 481 640 H,N    ~ \ < N \ Z     . cf, fY°0 453 699-P1 H2V / *n 481 641 =: ( XXX ( ° / z~z M CZ) Ul 511 699-P2 H2Vv^n /  \        CF, \    N- / N 481 642 hA / ^n / X< O ^vCF3 Z\^° r « J । Kz 11 N^Z\ "'C) 495 700 H,N V- / N YjyA <Y°O O   N.^ / \ 513 643 S Z=\      Jz ( XXX rA ° °\X^ z^\ ”5 O1 553 701 H,N \ Z^N Yjp\ /  \        CF, ON ( /     n^z A 509 644 s ( / OCX / O     / z-z ° \ 3 n 480 702 h2n < N NCz X' Z   ^^^CF, / OCT ' v—O 494 645 nCX zOo ^ysfs OvV \—o 538 703 z z£ aS1 453 646 498 704 H2N XX j N N-^ °oZ 464 647 s OCXA / O      / Z^z Z     /    *1 jA 497 705 H,N \ Xn / / \ J / N N-^ / c<r CN 463 648 529 706 H,N X \ j N N-^ Sx CN 420 649 H2Vn \ /        CF2H fVfX 435 707 H,N XX J N   N-^ 396 650 u o t / z-zZ °' / XXX J z z    \=^z s 469 708 H,N    ~ \ X \ J N N"^ W   XN fr°fX ___^■...X'n   CI--, 464 651 501 709 H,N \ X"N J        . VxN w ?—\ > f IxN 497 652 n J73 441 710 H2N 2 vV-o 499 653 w qx: z / UI 499 711 h2n 2 \ / ^N M ”x F~O 511 654 H,N r \ j N . 483 712 s cpx z ! n 483 655 H,N K? N 541 713 485 656 H2N    z^ \    / / N X\ JJ N X..... 468 714 497 657 H2N 2 \   / ^N J N %>• 526 715 s XI / O M % 395 658 H2N \ yzN 4 \ Jj N N^ O Xj h r L p f <  JA / '\ o 486 716 H2N \ Xn r \ JI N N-^ Jf 409 659 H2N \ zz N H J N N^ X^ 485 717 H2N    z^ 2 \ Xn X \ J N N-^ Yx / \^O   / 332 660 H2N / M jj N Q )O fr O £' —o 517 718 H,N JJ N N"^ W   CF / \^O ,_ / CF3 428 661 a o n 423 719 H,N \ / Z N t \ J N N-^ w 360 662 A / -0 /          CF, (ufy —o 443 720 H2N 2 \   / ^N W fr°fl _ / N^-N 409 663 ir, iZ2 M o—,      o ) Z \ XXX > z z   \=Z s 501 721 H2NW^n / j-A Q   CF / \-sO ,__ZCF3 442 Alternatively, the following examples were prepared using the following method: Example 427 4-Amino-12-((5-(2,6-difluorophenyl)pyridin-2-yl)methyl)-1-methyl- 5    1,7,9,10,11,12-hexahydro-13H-[1,5]oxazolo[7,8-g]pyrazolo[4,3-c]quinolin-13- one Referring to the preparation method of Example 1, Example 427 (5.2 mg, yield: 2.3%) was obtained from methyl 4-amino-2-bromobenzoate 427a (100 mg, 454 pmol). MS m / z (ESI): 516 [M+1]+ 1H NMR (400 MHz, DMSO-d6) S 8.66 (s, 1H), 8.36 (d, 1H), 8.16 - 8.05 (m, 1H), 7.98 (d, 1H), 7.70 (d, 1H), 7.64 - 7.48 (m, 2H), 7.30 (t, 2H), 5.25 (d, 1H), 4.75 (d, 1H), 4.59 (d, 1H), 4.52 - 4.34 (m, 3H), 3.87 - 3.75 (m, 1H), 3.54 - 3.36 (m, 2H), 3.26 (s, 2H), 2.03 - 1.87 (m, 1H), 1.32 - 1.19 (m, 1H). Example 431 4-Amino-12-(5-(2,6-difluorophenyl)pyridin-2-yl)methyl-3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolino[7,8-g]quinolin-13(1H)-one Referring to the synthesis method described in Step 5 to Step 8 of Example 14, Example 431  (14 mg, yield: 2.8%) was obtained from methyl 7-(3- bromopropyl)methyl-4-(3,4-dimethoxybenzyl)amino-1,3-dihydrofuro[3,4-c]quinoline-8-carboxylate 178e   (545 mg, 1 mmol) and (5-(2,6- difluorophenyl)pyridin-2-yl)methanamine (242 mg, 1.2 mmol). MS m / z (ESI): 503 [M+1]+ 1H NMR (400 MHz, DMSO-d6) S 8.66 (s, 1H), 7.97 (dd, 1H), 7.66 (d, 1H), 7.57 (s, 1H), 7.55 (m, 2H), 7.30 (m, 2H), 5.43 (s, 1H), 5.25 (d, 1H), 5.06 (br s, 2H), 4.75 (d, 1H), 4.60 (d, 1H), 4.35 (d, 1H), 3.82 (d, 1H), 3.45 (m, 2H), 3.26 (m, 2H), 1.91 (m, 1H), 1.23 (d, 1H). Example 434 4-Amino-3-methyl-12-((5-(pentafluorosulphanyl)pyridin-2-yl)methyl)-3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolo[7,8-g]quinolin-13(1H)-one Step 1: 2-Cyano-5-fluoropyridine 434a (50 g, 409.5 mmol) was dissolved in DMF (250 mL), and the mixture was cooled in an ice bath under nitrogen atmosphere. Na2S (38.35 g, 491.4 mmol) was added in portions, and the reaction system was stirred at 20°C for 1 hour. The reaction solution was slowly added to 1N NaOH solution (2 L), and the mixture was extracted with dichloromethane (2 L). The phases were separated, and the aqueous phase was collected. The pH was adjusted to 2, resulting in the precipitation of a large amount of solid. After filtration, the filtrate was slurried with isopropanol and water, and the solid was collected to obtain 434b (50 g, yield: 89.0%). MS m / z (ESI): 137 [M+1]+ Step 2: 434b (50 g, 367.1 mmol) was dissolved in acetonitrile (250 mL), sodium iodide (27.5 g, 183.59 mmol) and ferric chloride (30 g, 183.6 mmol) were added under nitrogen atmosphere, and the reaction system was stirred at 20°C for 3 hours. The reaction solution was filtered to remove insoluble materials, and the filtrate was concentrated and dissolved in ethyl acetate (2 L). The mixture was extracted with water (2 L), and the phases were separated. The organic phase was washed with a saturated sodium chloride aqueous solution, dried, and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent A to obtain a brown solid. The solid was purified by slurring with ethyl acetate to obtain 434c (10.5 g, yield: 21.1%). MS m / z (ESI): 271 [M+1]+ Step 3: Under nitrogen atmosphere, trichloroisocyanuric acid (83.82 g, 360.67 mmol) and super-dry potassium fluoride (27.94 g, 480.89 mmol) were added to a reaction flask, followed by anhydrous acetonitrile (130 mL). During stirring, 5,5’-dithiobis(2-cyanopyridine) 434c (6.50 g, 24.04 mmol) was added, and the mixture was stirred at 80°C for 5 h. Upon completion of the reaction, the reaction system was cooled to 20°C, and filtered, and the filter cake was washed with anhydrous acetonitrile (20 mL). The filtrate was concentrated under reduced pressure to remove the organic solvent to obtain 434d (crude, 14.80 g). 19F NMR (400 MHz) 8 136.3 ppm. Step 4: Silver tetrafluoroborate (28.08 g, 144.27 mmol) was added to a solution of 434d (14.80 g, crude) in anhydrous dichloromethane (130 mL). Under nitrogen atmosphere, the reaction suspension was heated to 40°C and stirred for 22 h. Upon completion of the reaction, the reaction system was concentrated under reduced pressure to remove the solvent dichloromethane, and ethyl acetate was added. The mixture was sonicated and filtered, and the filter cake was washed with ethyl acetate, and concentrated. The residue was purified by silica gel column chromatography using eluent system C to obtain 434e (5.5 g, 23.90 mmol, two-step yield: 49.7%). 1H NMR (400 MHz, CDCl3) 8 9.09 (d, 1H), 8.24 (dd, 1H), 7.87 (d, 1H) ppm; 19F NMR (400 MHz, CDCl3) 8 79.6 ppm. Step 5: 434e (5.7 g, 24.77 mmol) and 5% palladium on carbon (2.64 g) were dissolved in ethanol (100 mL), 4 M hydrogen chloride / methanol (37.15 mL, 148.59 mmol) was added, and the mixture was stirred at 20°C for 16 hours (15 psi hydrogen atmosphere). The reaction solution was filtered through Celite, and washed with methanol. The filtrate was concentrated to obtain a crude product, which was dispersed in ethyl acetate (50 mL), and filtered to obtain 434f (5.80 g, 21.43 mmol, yield: 86.5%). MS m / z (ESI): 271 [M+1]+ Step 6: Methyl 4-oxotetrahydrofuran-3-carboxylate 434g (45.6 g, 316.46 mmol) was dissolved in dichloromethane (500 mL), and N,N-diisopropylethylamine (64.50 g, 500.00 mmol) and trifluoromethanesulphonic anhydride (116.80 g, 400.00 mmol) were sequentially added in an ice bath. The mixture was stirred and reacted at room temperature for about 16 hours. Water (500 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (400 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 434h (75.3 g, yield: 86.1%). Step 7: 3-(Benzyloxy)propan-1-ol 434i (20 g, 120.48 mmol) was dissolved in tetrahydrofuran (400 mL), and sodium hydride (5.78 g, 144.57 mmol, 60% purity) was added in an ice bath. The mixture was stirred for 15 minutes, potassium (bromomethyl)trifluoroborate (24.09 g, 120.00 mmol) was then added, and the mixture was stirred and reacted at room temperature for about 16 hours. A potassium bifluoride solution (4.5 M) was added to the reaction solution, and the mixture was stirred at room temperature for 30 minutes. The reaction solution was subjected to rotary evaporation to dryness, and then hot acetone (2000 mL) was added, and the resulting mixture was stirred at 80°C for about 15 minutes. After hot filtration to remove impurities, the acetone was distilled under reduced pressure until solids precipitated. Twice the volume of diethyl ether was added, and the mixture was filtered in an ice bath. The filter residue was dried to obtain 437j (12.5 g, yield: 37.9%). Step 8: Methyl 4-amino-5-bromo-2-chlorobenzoate 434k (80 g, 302.45 mmol), bis(pinacolato)diboron      (115.21      g,      453.68      mmol),      1,1'- bis(diphenylphosphino)ferrocene (16.77 g, 30.25 mmol), potassium acetate (59.37 g, 604.91 mmol), and palladium acetate (3.40 g, 15.12 mmol) were added to 1,4-dioxane (800 mL), and the reaction system was stirred at 80°C under nitrogen atmosphere for 16 hours. The reaction solution was cooled to room temperature, and filtered to remove insoluble materials. The filtrate was concentrated, and the residue was purified by silica gel column chromatography using eluent system B to obtain methyl 4-amino-2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 434l (84 g, 269.60 mmol, yield: 89.1%). MS m / z (ESI): 312 [M+1]+ Step 9: 434l (70.5 g, 226.27 mmol) was added to ethanol (1000 mL) and water (200 mL), followed by methyl 4-(((trifluoromethyl)sulphonyl)oxy)-2,5-dihydrofuran-3-carboxylate (62.49 g, 226.27 mmol), sodium carbonate (47.97 g, 452.55 mmol) and bis(triphenylphosphine)palladium(II) dichloride (15.88 g, 22.63 mmol), and the reaction system was reacted at 80°C under nitrogen atmosphere for 4 hours. The reaction solution was directly concentrated, water was added, and the mixture was stirred for 10 min. The resulting system was filtered by suction, and the solid was slurried with ethyl acetate, to obtain 434m (49 g, 175.20 mmol, yield: 77.4%). MS m / z (ESI): 280 [M+1]+ Step 10: 434m (56.7 g, 202.74 mmol) was dissolved in dimethyl sulphoxide (25.23 mL), and 2,4-dimethoxybenzylamine (40.68 g, 243.28 mmol) and 1,8-diazabicyclo[5.4.0]undec-7-ene (92.59 g, 608.21 mmol, 90.78 mL) were added, followed by a BOP reagent (269.00 g, 608.21 mmol). The reaction system was reacted at room temperature for 1 hour. The reaction solution was poured into ice water, and extracted with ethyl acetate. The organic phase was separated, dried, concentrated, and slurried with methanol to obtain 434n (43 g, 100.26 mmol, yield: 49.5%). MS m / z (ESI): 429 [M+1]+ Step 11:    434n    (2.5 g, 5.83 mmol), potassium ((3- (benzyloxy)propoxy)methyl)trifluoro-L4-borate (2.50 g, 8.74 mmol), [n-butyl-di(1-adamantyl)phosphine](2-amino-1,1'-biphenyl-2-yl)palladium(II) methanesulphonate (424.53 mg, 582.93 pmol), and caesium carbonate (5.70 g, 17.49 mmol) were placed in a sealed tube, 1,4-dioxane (20 mL) and water (2 mL) were added, and the reaction system was reacted at 90°C under nitrogen atmosphere for 16 hours. The reaction solution was added to a saturated sodium chloride aqueous solution, and extracted with ethyl acetate (100 mL x 3). The organic phase was washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated under reduced pressure to remove the organic solvent. The residue was purified by silica gel column chromatography using eluent system B to obtain 434o (1.76 g, 3.07 mmol, yield: 52.7%). MS m / z (ESI): 573 [M+1]+ Step 12: 434o (17.1 g, 29.86 mmol) was dissolved in tetrahydrofuran (170 mL) and methanol (170 mL), acetic acid (10 mL), 10% wt palladium on carbon (8.55 g, 80.34 mmol) and 10% wt palladium hydroxide on carbon (8.55 g, 60.88 mmol) were added, and the reaction system was reacted at 50°C under hydrogen atmosphere at 60 psi pressure for 20 hours. The reaction solution was filtered by suction, and the filtrate was concentrated to obtain 434p (9.64 g, 19.98 mmol, yield: 66.9%). MS m / z (ESI): 483 [M+1]+ Step 13: 434p (9.64 g, 19.98 mmol) was dissolved in dichloromethane (100 mL), carbon tetrabromide (6.63 g, 19.98 mmol) and triphenylphosphine (5.24 g, 19.98 mmol) were added, and the reaction system was reacted at room temperature under nitrogen atmosphere for 3 hours. The reaction solution was directly concentrated, and the residue was purified by silica gel column chromatography using eluent system A to obtain 434q (12.64 g, 16.45 mmol, yield: 82.4%). MS m / z (ESI): 545 [M+1]+ Step 14: A solution of 434f (4.47 g, 16.50 mmol), 434q (5.00 g, 9.17 mmol), sodium iodide (2.75 g, 18.33 mmol) and caesium carbonate (5.97 g, 18.33 mmol) in acetonitrile (50 mL) was reacted at 80°C for 15 hours. The reaction system was quenched with water, and extracted with ethyl acetate (100 mL x 3). The organic phase was dried over anhydrous sodium sulphate, filtered, and concentrated to remove the organic solvent. The residue was purified by silica gel column chromatography using eluent system C to obtain 434r (3.10 g, 4.44 mmol, yield: 48.4%). MS m / z (ESI): 699 [M+1]+ Step 15: 434r (3.30 g, 4.72 mmol) was dissolved in tetrahydrofuran (20 mL) and methanol (20 mL), 4M lithium hydroxide solution (5.90 mL, 23.62 mmol) was added, and the mixture was reacted at 50°C for 4 hours. The reaction system was adjusted to pH 2-3 with 1 M dilute hydrochloric acid, and extracted with ethyl acetate (50 mL x 3). The organic phase was washed with a saturated sodium chloride aqueous solution (30 mL), dried over anhydrous sodium sulphate, filtered, and concentrated under reduced pressure to obtain 4-((2,4-dimethoxybenzyl)amino)-7-((3-(((5-(pentafluoro-X,6-sulphanyl)pyridin-2-yl)methyl)amino)propoxy)methyl)-1,3-dihydrofuro[3,4-c]quinoline-8-carboxylic acid 434s (3.00 g, crude). MS m / z (ESI): 685 [M+1]+ Step 16: 434s (3.00 g, 4.38 mmol) and 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (2.48 g, 6.57 mmol) were dissolved in N,N-dimethylformamide (15 mL), N,N-diisopropylethylamine (1.13 g, 8.76 mmol, 1.53 mL) was added, and the mixture was reacted at 25°C for 16 hours. The reaction system was quenched with water, and extracted with ethyl acetate (80 mL x 3). The organic phase was washed with a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulphate, filtered, and concentrated to remove the organic solvent. The residue was purified by silica gel column chromatography using eluent system C to obtain 434t (2.00 g, 3.00 mmol, yield: 47.9%). MS m / z (ESI): 667 [M+1]+ Step 17: 434t (2.00 g, 3.00 mmol) was dissolved in trifluoroacetic acid (10 mL), and the reaction system was reacted at 90°C under nitrogen atmosphere for 1 hour. The reaction solution was concentrated, and the residue was purified by preparative HPLC chromatography to obtain Example 434 (893 mg, 0.51 mmol, yield: 57.6%). MS m / z (ESI): 517 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.11 (d, 1H), 8.40 (dd, 1H), 7.76 (d, 1H), 7.51 (s, 1H), 7.39 (s, 1H), 6.65 (s, 2H), 5.35 (t, 2H), 5.16 (d, 1H), 5.01 (t, 2H), 4.72 (d, 1H), 4.53 (d, 1H), 4.43 (d, 1H), 3.78 (dt, 1H), 3.41 (m, 2H), 3.25 (m, 1H), 1.91 (q, 1H), 1.25 (m, 1H) Example 435 4-Amino-12-((5-(2,6-difluorophenyl)pyridin-2-yl)methyl)-3-methyl-1,3,7,8,9,10,11,12-octahydro-13H-[1,5]diamine[7,8-g]furo[3,4-c]quinolin-13- one Referring to Step 1 to Step 11 of Example 178, Example 435 (21 mg, yield: 0.45%) was obtained from methyl 2-methyl-4-oxotetrahydrofuran-3-carboxylate 184e (4 g, 9.03 mmol) through steps of coupling, deprotection, bromination, substitution, hydrolysis, cyclisation, and deprotection. MS m / z (ESI): 515 [M+1]+ 1HNMR (400 MHz, DMSO-d6) 5 8.96 (d, 1H), 8.26 - 8.22 (m, 1H), 7.75 (m, 1H), 7.56(s, 1H), 7.50 (s, 1H), 7.38 (s, 1H), 7.15 (m, 2H), 6.56 (s, 2H), 5.47 - 5.24 (m, 4H), 5.19 (m, 1H), 4.71 (m, 1H), 4.53 (m, 1H), 4.43 (d, 1H), 3.77 (d, 1H), 3.23 (d, 2H), 2.03 - 1.88 (m, 2H), 1.40 (d, 3H). Example 437 4-Amino-3-methyl-12-((5-(pentafluorosulphanyl)pyridin-2-yl)methyl)-3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolo[7,8-g]quinolin-13(1H)-one HO OBn 437a 437b Step 1: 3-(Benzyloxy)propan-1-ol 437a (20 g, 120.48 mmol) was dissolved in tetrahydrofuran (400 mL), and sodium hydride (5.78 g, 144.57 mmol, 60% purity) was added in an ice bath. The mixture was stirred for 15 minutes, potassium 5 (bromomethyl)trifluoroborate (24.09 g, 120.00 mmol) was then added, and the mixture was stirred and reacted at room temperature for about 16 hours. A potassium bifluoride solution (4.5 M) was added to the reaction solution, and the mixture was stirred at room temperature for 30 minutes. The reaction solution was subjected to rotary evaporation to dryness, and then hot acetone (2000 mL) was added, and the 10 resulting mixture was stirred at 80°C for about 15 minutes. After hot filtration to remove impurities, the acetone was distilled under reduced pressure until solids precipitated. Twice the volume of diethyl ether was added, and the mixture was filtered in an ice bath. The filter residue was dried to obtain 437b (12.5 g, yield: 37.9%). 15        Step 2: 2-Cyano-5-mercaptopyridine 437c (20 g, 147.06 mmol) was dissolved in tetrahydrofuran (400 mL), and iodine (11.12 g, 44.12 mmol) was added in an ice bath. The mixture was stirred and reacted at room temperature for about 16 hours. A saturated sodium thiosulphate solution was added to the reaction solution, and the mixture was stirred at room temperature for 30 minutes, and extracted with ethyl acetate (400 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 437d (15.7 g, yield: 79.1%). MS m / z (ESI): 271 [M+1]+ Step 3: 437d (15.7 g, 58.15 mmol) was dispersed in acetonitrile (400 mL), and tetraethylammonium chloride (19.19 g, 116.30 mmol) and silver difluoride (134.91 g, 930.40 mmol) were added in an ice bath. The mixture was stirred and reacted at room temperature for about 16 hours. The reaction solution was filtered, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 437e (5.62 g, yield: 21.0%). MS m / z (ESI): 231 [M+1]+ Step 4: 437e (5.62 g, 24.43 mmol) was dispersed in methanol (50 mL), and palladium on carbon (5 g, 10%) was added. The mixture was stirred and reacted at room temperature under hydrogen atmosphere for about 16 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure to obtain 437f (4.61 g, yield: 80.1%). MS m / z (ESI): 235 [M+1]+ Step 5: Methyl 2-methyl-4-oxotetrahydrofuran-3-carboxylate 437g (50 g, 316.46 mmol) was dissolved in dichloromethane (500 mL), and N,N-diisopropylethylamine (64.50 g, 500.00 mmol) and trifluoromethanesulphonic anhydride (116.80 g, 400.00 mmol) were sequentially added in an ice bath. The mixture was stirred and reacted at room temperature for about 16 hours. Water (500 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (400 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 437h (82.5 g, yield: 89.9%). Step 6: 437h (40.51 g, 139.69 mmol) and 437i (40.43 g, 130.00 mmol) were dissolved in dioxane (400 mL) and water (100 mL), and (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride (4.75 g, 6.50 mmol) and potassium carbonate (53.82 g, 390.00 mmol) were added. The mixture was stirred and reacted at 100°C under nitrogen atmosphere for about 16 hours. The reaction solution was filtered, and the filtrate was extracted with ethyl acetate (200 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 437j (24.80 g, yield: 65.1%). MS m / z (ESI): 294 [M+1]+ Step 7: 437j (24.80 g, 84.64 mmol) was dissolved in dimethyl sulphoxide (200 mL), and 2,4-dimethoxybenzylamine (26.72 g, 160.00 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (36.48 g, 240.00 mmol) and a BOP reagent (70.72 g, 160.00 mmol) were sequentially added. The mixture was stirred and reacted at room temperature under nitrogen atmosphere for about 2 hours. The reaction solution was poured into water (2000 mL) and ethyl acetate (300 mL), and the precipitated solid was filtered to obtain 437k (26.97 g, yield: 72.1%). MS m / z (ESI): 443 [M+1]+ Step 8: 437k (18.33 g, 41.47 mmol), 437b (12.5 g, 45.62 mol), [n-butyl-di(1-adamantyl)phosphine](2-amino-1,1'-biphenyl-2-yl)palladium(II) methanesulphonate (4.44 g, 6.10 mol) and sodium carbonate (8.80 g, 83.00 mmol) were dissolved in toluene (200 mL) and water (40 mL), and the mixture was reacted at 100°C under nitrogen atmosphere for 16 hours. The reaction solution was extracted with ethyl acetate (200 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 437l (16.45 g, yield: 67.7%). MS m / z (ESI): 587 [M+1]+ Step 9: 437l (16.45 g, 28.07 mmol) was dissolved in tetrahydrofuran (200 mL), methanol (100 mL) and acetic acid (3 mL). Palladium on carbon (5 g, 10%) and palladium hydroxide on carbon (5 g, 10%) were added, and the mixture was reacted at 50°C under hydrogen atmosphere for 16 hours. The reaction solution was filtered, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 437m (10.15 g, yield: 72.9%). MS m / z (ESI): 497 [M+1]+ Step 10: 437m (10.15 g, 20.46 mmol) and triphenylphosphine (13.40 g, 51.15 mmol) were dissolved in dichloromethane (200 mL). Carbon tetrabromide (16.93 g, 51.15 mmol) was added, and the mixture was reacted at room temperature under nitrogen atmosphere for 1 hour. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 437n (9.87 g, yield: 86.4%). MS m / z (ESI): 559 [M+1]+ Step 11: 437n (4.00 g, 7.17 mmol), 437f (2.01 g, 8.60 mmol), potassium carbonate (4.95 g, 35.85 mmol) and sodium iodide (2.15 g, 14.34 mmol) were dispersed in acetonitrile (40 mL). The mixture was reacted at 80°C under nitrogen atmosphere for 16 hours. The reaction solution was filtered, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 437o (2.21 g, yield: 43.3%). MS m / z (ESI): 713 [M+1]+ Step 12: 437o (2.21 g, 3.10 mmol) was dissolved in methanol (30 mL) and water (10 mL), and lithium hydroxide (372 mg, 15.50 mmol) was added. The mixture was reacted at room temperature under nitrogen atmosphere for 16 hours. The reaction solution was concentrated under reduced pressure to remove most of the solvent, and water (20 mL) was added to the residue. The mixture was adjusted to pH 6 with 6 N hydrochloric acid, and the precipitated solid was filtered to obtain 437p (1.75 g, yield: 80.8%). MS m / z (ESI): 699 [M+1]+ Step 13: 437p (300 mg, 0.43 mmol) and N,N-diisopropylethylamine (277 mg, 2.15 mmol) were dissolved in N,N-dimethylformamide (20 mL), and O-(7-azabenzotriazol-1-yl)-N, N, N, N-tetramethyluronium hexafluorophosphate (327 mg, 0.86 mmol) was added. The mixture was reacted at room temperature under nitrogen atmosphere for 1 hour. Water (80 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (40 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 437q (210 mg, yield: 71.9%). MS m / z (ESI): 681 [M+1]+ Step 14: 437q (100 mg, 0.15 mmol) was dissolved in trifluoroacetic acid (5 mL). The mixture was reacted at 80°C under nitrogen atmosphere for 1 hour. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography using eluent system A to obtain 437 (41 mg, yield: 52.6%). MS m / z (ESI): 531 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.11 (d, 1H), 8.40 (dd, 1H), 8.08 (d, 2H), 7.78 (d, 1H), 7.61 (d, 2H), 5.55 - 5.34 (m, 3H), 5.17 (dd, 1H), 4.68 (ddd, 2H), 4.46 (d, 1H), 3.83 (d, 1H), 3.53 - 3.21 (m, 3H), 1.91 (s, 1H), 1.43 (d, 3H), 1.24 (d, 1H). Example 437-P1 (R)-4-Amino-3-methyl-12-((5-(pentafluorosulphanyl)pyridin-2-yl)methyl)-3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolo[7,8-g]quinolin-13(1H)-one 437<>-P1                                                 437p-PI                                                                                                         437-P1 Step 1:   Methyl   4-((2,4-dimethoxybenzyl)amino)-3-methyl-7-((3-(((5- (pentafluorosulphanyl)pyridin-2-yl)methyl)amino)propoxy)methyl)-1,3-dihydrofuro[3,4-c]quinoline-8-carboxylate 437o (1.91 g, 2.68 mmol) was separated by chiral preparative HPLC to obtain methyl (R)-4-((2,4-dimethoxybenzyl)amino)-3-methyl-7-((3-(((5-(pentafluorosulphanyl)pyridin-2-yl)methyl)amino)propoxy)methyl)-1,3-dihydrofuro[3,4-c]quinoline-8-carboxylate 437o-P1 (810 mg, tR = 2.504 min, yield: 42.4%) and methyl (S)-4-((2,4-dimethoxybenzyl)amino)-3-methyl-7-((3-(((5-(pentafluorosulphanyl)pyridin-2-yl)methyl)amino)propoxy)methyl)-1,3-dihydrofuro[3,4-c]quinoline-8-carboxylate 437o-P2 (760 mg, tR = 3.825 min, yield: 39.8%). Referring to Step 12 to Step 14 of Example 437, compound (R)-4-amino-3-methyl-12-((5-(pentafluorosulphanyl)pyridin-2-yl)methyl)-3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolo[7,8-g]quinolin-13(1H)-one 437-P1  (129 mg, yield:   21.4%) was obtained from compound methyl   (R)-4-((2,4- dimethoxybenzyl)amino)-3-methyl-7-((3-(((5-(pentafluorosulphanyl)pyridin-2-yl)methyl)amino)propoxy)methyl)-1,3-dihydrofuro[3,4-c]quinoline-8-carboxylate 437o-P1 (810 mg, 1.14 mmol). MS m / z (ESI): 531 [M+1]+ 1HNMR (400 MHz, DMSO-d6) 5 9.11 (d, 1H), 8.40 (dd, 1H), 8.08 (d, 2H), 7.78 (d, 1H), 7.61 (d, 2H), 5.55 - 5.34 (m, 3H), 5.17 (dd, 1H), 4.68 (ddd, 2H), 4.46 (d, 1H), 3.83 (d, 1H), 3.53 - 3.21 (m, 3H), 1.91 (s, 1H), 1.43 (d, 3H), 1.24 (d, 1H). Example 437-P2 (S)-4-Amino-3-methyl-12-((5-(pentafluorosulphanyl)pyridin-2-yl)methyl)-3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolo[7,8-g]quinolin-13(1H)-one 437o-P2 437p-P2 437q-P2 437-P2 Referring to Step 12 to Step 14 of Example 437, compound (S)-4-amino-3-methyl-12-((5-(pentafluorosulphanyl)pyridin-2-yl)methyl)-3,7,9,10,11,12-hexahydrofuro[3,4-c][1,5]oxazolo[7,8-g]quinolin-13(1H)-one 437-P2  (115 mg, yield:   20.2%) was obtained from compound methyl   (S)-4-((2,4- dimethoxybenzyl)amino)-3-methyl-7-((3-(((5-(pentafluorosulphanyl)pyridin-2-yl)methyl)amino)propoxy)methyl)-1,3-dihydrofuro[3,4-c]quinoline-8-carboxylate 437o-P2 (760 mg, 1.07 mmol). MS m / z (ESI): 531[M+1] 1HNMR (400 MHz, DMSO-d6) 5 9.11 (d, 1H), 8.40 (dd, 1H), 8.08 (d, 2H), 7.78 (d, 1H), 7.61 (d, 2H), 5.55 - 5.34 (m, 3H), 5.17 (dd, 1H), 4.68 (ddd, 2H), 4.46 (d, 1H), 3.83 (d, 1H), 3.53 - 3.21 (m, 3H), 1.91 (s, 1H), 1.43 (d, 3H), 1.24 (d, 1H). Example 484 4-Amino-12-((5-(bicyclo[1.1.1]pentan-1-yl)pyridin-2-yl)methyl)-9,10,11,12- tetrahydroimidazo[1,5-a][1,5]oxazolo[8,7-g]quinoxalin-13(7H)-one Step 1: tert-Butyl N-[(5-bromo-2-pyridyl)methyl]carbamate (1 g, 3.48 mmol), 2-(bicyclo[1.1.1]pentan-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 484a (1.01 g, 5.22 mmol, prepared according to a known method: “Science, 2017, vol. 357, p. 283 -        286”),        bis[2-(2,4-difluorophenyl)-5-trifluoromethylpyridine][2-2'- bipyridine]iridium(III) hexafluorophosphate (70 mg, 70 pmol) and [4,4'-bis(1,1- dimethylethyl)-2,2'-bipyridine]nickel(II) dichloride (277 mg, 0.7 mmol) were dissolved in N,N-dimethylformamide (20 mL), and the mixture was purged three times with nitrogen. Morpholine (455 mg, 5.22 mmol, 0.47 mL) was added, and the system was irradiated in a blue light reactor (18 w, 456 nm) for 15 hours. The resulting reaction system was quenched with water, and extracted with ethyl acetate (50 mL x 3). The organic phases were combined, washed sequentially with a saturated sodium chloride aqueous solution (30 mL), dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography using eluent system B to obtain 484b (200 mg, yield: 21.0%). MS m / z (ESI): 275 [M+1]+ Step 2: 484b (0.45 g, 1.64 mmol) and hydrogen chloride in dioxane (5 mL) were dissolved in 1'4-dioxane (5 mL), and the system was reacted at 25°C for 1 hour. The resulting reaction system was concentrated to obtain 484c (0.28 g, crude). MS m / z (ESI): 175 [M+1]+ Referring to the synthesis method described in Step 6 to Step 9 of Example 1304, Example 484 (10 mg, yield: 4.0%) was obtained from 484c (106 mg, 0.61 mmol)        and        methyl        7-((3-bromopropoxy)methyl)-4-(3,4- dimethoxybenzyl)amino)imidazo[1,5-a]quinoxaline-8-carboxylate 484d (300 mg, 0.55 mmol). MS m / z (ESI): 455 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 8 9.21 (s, 1H), 8.41 (d, 1H), 8.07 (s, 1H), 7.91 (s, 1H), 7.67 (dd, 1H), 7.49 (d, 1H), 7.39 (d, 3H), 5.19 (d, 1H), 4.61 (d, 1H), 4.51 (d, 1H), 4.26 (d, 1H), 3.73 (d, 1H), 3.51 (d, 2H), 3.15 (d, 2H), 2.59 (s, 1H), 2.12 (s, 5H), 1.89 (d, 1H), 1.22 (d, 1H). Example 493 4-Amino-8-methyl-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)- 7,8,9,10,11,12-hexahydro-13H-[1,5]diazo[7,8-g]imidazo[1,5-a]quinoxalin-13- one Step 1: 493a (18 g, 103.89 mmol) was dissolved in tetrahydrofuran (200 mL), and sodium hydride (3.59 g, 89.63 mmol, 60% purity) was added in an ice bath. The mixture was stirred for 15 minutes, potassium (bromomethyl)trifluoroborate (18 g, 89.63 mmol) was then added, and the mixture was stirred and reacted at room temperature for about 16 hours. A potassium bifluoride solution (4.5 M) was added to the reaction solution, and the mixture was stirred at room temperature for 30 minutes. The reaction solution was subjected to rotary evaporation to dryness, and then hot acetone (100 mL) was added, and the resulting mixture was stirred at 80°C for about 15 minutes. After hot filtration to remove impurities, the acetone was distilled under reduced pressure until solids precipitated. Twice the volume of diethyl ether was added, and the mixture was filtered in an ice bath. The filter residue was dried to obtain 493b (27 g, crude, yield: 100%). Step 2:   Methyl 7-bromo-4-((3,4-dimethoxybenzyl)amino)imidazo[1,5- a]quinoxaline-8-carboxylate (4.5 g, 9.55 mmol), 493b (4.48 g, 15.28 mmol), [n-butyl-di(1-adamantyl)phosphine](2-amino-1,1'-biphenyl-2-yl)palladium(II) methanesulphonate (347.68 mg, 477.40 pmol) and caesium carbonate (9.34 g, 28.64 mmol) were dissolved in dioxane (50 mL) and water (10 mL), and the mixture was reacted at 100°C under nitrogen atmosphere for 16 hours. Water (100 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (100 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system B to obtain 493c (5.52 g, crude), which was used directly in the next step. MS m / z (ESI): 578 [M+1]+ Step 3: 493c (5.4 g, 9.35 mmol) was added to a single-necked flask containing methanol (20 mL) and tetrahydrofuran (20 mL), and the mixture was adjusted to pH=7 with HCl (2 M, 46.74 mL) under nitrogen atmosphere, and stirred at room temperature for 2 hours. The reaction was quenched by adding a saturated ammonium chloride solution (100 mL) to the reaction solution, and extracted with ethyl acetate (100 mL x 2). After extraction, the organic phase was separated, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 493d (1.1 g, 2.23 mmol, yield: 23.8%). MS m / z (ESI): 494 [M+1]+ Step 4: 493d (1.1 g, 2.23 mmol) was dissolved in dichloromethane (20 mL), and the mixture was purged three times with nitrogen and cooled to 0°C. Triphenylphosphine (876.85 mg, 3.34 mmol) and carbon tetrabromide (1.11g, 3.34 mmol) were then added, and the system was reacted at 25°C for 2 hours. The reaction solution was distilled under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 493e (0.24 g, 431.31 pmol, yield: 19.4%). MS m / z (ESI): 556 / 558 [M+1]+ Step 5:  493e  (0.24 g, 431.31 pmol), (5-(trifluoromethyl)pyridin-2- yl)methanamine (151.94 mg, 862.61 pmol), sodium iodide (129.30 mg, 862.61 pmol) and potassium carbonate (119.04 mg, 862.61 gmol) were dissolved in acetonitrile (10 mL), and the mixture was purged three times with nitrogen. The reaction system was reacted at 80°C for 15 hours. The reaction solution was quenched with water, extracted with ethyl acetate (50 mL x 2), and washed with a saturated sodium chloride aqueous solution (50 mL x 2). The organic phase was dried over anhydrous sodium sulphate, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using eluent system C to obtain 493f (0.13 g, 199.49 pmol, yield: 46.3%). MS m / z (ESI): 652 [M+1]+ Step 6: 493f (0.13 g, 199.49 pmol) was dissolved in tetrahydrofuran (5 mL), water (5 mL) and methanol (5 mL), lithium hydroxide (33.51 mg, 797.94 pmol) was added, and the mixture was purged three times with nitrogen. The reaction system was reacted at 25°C for 16 hours. The resulting reaction system was adjusted to pH 5-6 with 1 M dilute hydrochloric acid, extracted with ethyl acetate (50 mL x 3), and washed with a saturated sodium chloride aqueous solution (50 mL x 2). The organic phase was dried over anhydrous sodium sulphate, and the filtrate was concentrated under reduced pressure to obtain 493g (0.08 g, 125.46 pmol, yield: 62.9%). MS m / z (ESI): 638 [M+1]+ Step 7: 493g (0.08 g, 125.46 pmol) and 2-(7-azobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (95.35 mg, 250.92 pmol) were dissolved in N,N-dimethylformamide (5 mL), N,N-diisopropylethylamine (97.29 mg, 752.76 pmol, 131.12 pL) was added, and the reaction system was reacted at 25 °C for 2 hours. The resulting reaction system was quenched with water, extracted with ethyl acetate (80 mL x 3), washed with a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulphate, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography using eluent system A to obtain 493h (0.076 g, 122.65 pmol, crude), which was directly used in the next step. MS m / z (ESI): 620 [M+1]+ Step 8: 493h (76.07 mg, 122.76 pmol) was dissolved in trifluoroacetic acid (5 mL), and the reaction system was reacted at 90°C for 0.5 hours. The resulting reaction system was concentrated, and the residue was purified by Pre-HPLC to obtain Example 493 (3 mg, 6.39 pmol, yield: 5.2%). MS m / z (ESI): 470 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 5 9.19 (s, 1H), 8.97 (s, 1H), 8.22 (dd, 1H), 8.01 (s, 1H), 7.90 (s, 1H), 7.84 (d, 1H), 7.36 (s, 2H), 7.32 (s, 1H), 5.16 (d, 1H), 4.41 (d, 1H), 3.80 (d, 1H), 3.55 (s, 1H), 3.25 (d, 4H), 2.33 (s, 3H), 1.36 - 0.93 (m, 2H). Example 502 4-Amino-1,8-dimethyl-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-7,8,9,10,11,12-hexahydro-[1,5]diazonino[7,8-g]pyrazolo[4,3-c]quinolin-13(1H)- one Step 1: A solution of methyl 7-chloro-4-((2,4-dimethoxybenzyl)amino)-1-methyl-1H-pyrazolo[4,3-c]quinoline-8-carboxylate 502a (800 mg, 1.65 mmol), potassium      trifluoro((methyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)amino) methyl)borate 502b (725 mg, 2.47 mmol), caesium carbonate (1.61 g, 4.95 mmol), and CataCxiumA-Pd-G3 (120.05 mg, 0.16 mmol) in 1,4-dioxane (15 mL) and water (3 mL) was stirred at 100°C under nitrogen atmosphere for 4 hours. The reaction solution was filtered to remove solids, and the filtrate was diluted with ethyl acetate (250 mL), and washed with water and a sodium chloride aqueous solution. The organic phase was concentrated, and the residue was purified by silica gel column chromatography to obtain 502c (602 mg, yield: 61.7%). MS m / z (ESI): 592 [M+1]+ Step 2: 4 N hydrochloric acid (0.20 mL, 5.00 mmol) was added to a solution of 502c (602 mg, 1.02 mmol) in methanol (15 mL), and the mixture was stirred at 20°C for 2 hours. Upon completion of the reaction, the reaction system was quenched with a sodium bicarbonate solution, extracted with DCM, dried, and subjected to rotary evaporation to dryness and column chromatography to obtain 502d (515 mg, yield: 99.7%). MS m / z (ESI): 508 [M+1]+ Referring to the synthesis method described in Step 5 to Step 9 of Example 62, Example 502 (6.5 mg, yield: 1.3%) was obtained from 502d (515 mg, 1.01 mmol). MS m / z (ESI): 484 [M+1] + 1H NMR (400 MHz, DMSO-d6) 8 8.89 (s, 1H), 8.63 - 8.36 (m, 3 H), 8.22 -8.11 (m, 1 H), 8.01 - 7.54 (m, 2 H), 7.31 - 7.11 (m, 1 H), 6.30 - 5.91 (m, 1 H), 5.71 - 5.44 (m, 1 H), 5.41 - 5.22 (m, 1 H), 5.14 - 4.85 (m, 2 H), 4.57 - 4.41 (m, 3 H), 4.34 - 4.06 (m, 2 H), 3.52 - 3.17 (m, 3 H), 2.58 - 2.52 (m, 2 H), 2.29 - 2.15 (m, 1 H). Example 503 4-Amino-1-methyl-12-((3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)methyl)-1,7,9,10,11,12-hexahydro-13H-[1,5]oxazolo[7,8-g]pyrazolo[4,3-c]quinolin-13- one Step 1: 3-(Trifluoromethyl)bicyclo[1.1.1]pentane-1-carboxylic acid 503a (5 g, 27.76 mmol) was dissolved in DCM (50 mL), oxaloyl chloride (4.58 g, 36.09 mmol, 3 mL) was added, and the mixture was stirred at 25°C for 2 hours. A solution of ammonia in methanol (7 M, 11.90 mL) was added, and the resulting mixture was purged three times with nitrogen, and stirred and reacted at 25°C under nitrogen atmosphere for 16 hours. The reaction solution was concentrated under reduced pressure, and water (100 mL) was added to the concentrated residue. The mixture was stirred for 15 minutes and filtered, and the filter cake was azeotroped with ethanol (60 mL) and dried under reduced pressure to obtain 503b (3.5 g, yield: 70.4%). 1H NMR (400 MHz, DMSO-d6) S 7.45 (s, 1H), 7.15 (s, 1H), 2.12 (s, 6H). Step 2: 503b (2.2 g, 12.28 mmol) was dissolved in THF (30 mL), and the reaction system was cooled to 0°C. LiAlH4 (2.5 M, 14.7 mL) was slowly added, and the mixture was purged three times with nitrogen, and stirred and reacted at 25°C under nitrogen atmosphere for 16 hours. A sodium hydroxide aqueous solution (6 M, 10 mL) was slowly added to the reaction solution, and the mixture was filtered. The filter cake was rinsed with diethyl ether (30 mL), and the filtrate was collected, filtered, and concentrated under reduced pressure (without being subjected to rotary evaporation to dryness). Diethyl ether (10 mL) was added to the concentrated residue, followed by hydrogen chloride in ethyl acetate (7 M, 6 mL), and the resulting mixture was stirred at 25°C for 15 minutes and filtered. The filter cake was collected and dried under reduced pressure to obtain 503c (900 mg, yield: 44.4%). 1H NMR (400 MHz, DMSO-d6) S 3.45 (d, 2H), 2.99 (d, 2H),1.99 (s, 6H). Step 3:    Compound methyl    7-((3-bromopropoxy)methyl)-4-(3,4- dimethoxybenzyl)amino)-1-methyl-1H-pyrazolo[4,3-c]quinoline-8-carboxylate 503d (200 mg, 359 amoi) and 503c (108.51 mg, 538 umol) were dissolved in MeCN (2 mL), and Nai (107.56 mg, 718 gmol) and K2CO3 (198.34 mg, 1.44 mmol) were sequentially added. The mixture was purged three times with nitrogen, and stirred and reacted at 80°C under nitrogen atmosphere for 16 hours. The reaction solution was filtered, the filtrate was concentrated under reduced pressure, and the concentrated residue was separated and purified by Pre-HPLC to obtain 503e (90 mg, yield: 29.0%). MS m / z (ESI): 642 [M+1]+ Step 4: 503e (80 mg, 125 umol) was dissolved in THF (0.6 mL) / MeOH (0.2 mL) / water (0.2 mL), and LiOH (11.94 mg, 499 umol) was added. The mixture was purged three times with nitrogen, and stirred and reacted at 25°C under nitrogen atmosphere for 16 hours. The reaction solution was concentrated under reduced pressure, and water (6 mL) was added to the concentrated residue. The mixture was adjusted to pH 4-5 with 2 M hydrochloric acid and filtered, and the filter cake was dried under reduced pressure to obtain 503f (90 mg, crude), which was used directly in the next step. MS m / z (ESI): 629 [M+1]+ Step 5: 503f (85 mg, 135 pmol) was dissolved in DMF (456 pL), and DIEA (35.01 mg, 271 pmol, 47 pL) and HATU (76.64 mg, 203 pmol) were sequentially added. The mixture was purged three times with nitrogen, and stirred and reacted at 25°C under nitrogen atmosphere for 5 hours. The reaction solution was concentrated under reduced pressure to obtain 503g (90 mg, crude). Step 6: 503g (85 mg, 139 pmol) was dissolved in TFA (1 mL), and the mixture was purged three times with nitrogen, and stirred and reacted at 80°C under nitrogen atmosphere for 0.5 hours. The reaction solution was concentrated under reduced pressure, and the concentrated residue was separated and purified by Pre-HPLC to obtain Example 503 (10 mg). MS m / z (ESI): 460 [M+1]+ 1H NMR (400 MHz, DMSO-d6) 8 13.34 (s, 2H), 8.53 (s, 1H), 7.98 (s, 1H), 7.64 (s, 1H), 4.70 (d, 1H), 4.54 (d, 1H), 4.46 (s, 2H), 4.10 (d, 1H), 3.84 - 3.74 (m, 1H), 3.37 (dd, 3H), 3.31 - 3.09 (m, 4H), 2.05 - 1.98 (m, 4H), 1.86 (q, 1H), 1.22 (d, 1H). Example 508 4-Amino-8-methyl-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1,3,7,8,9,10,11,12-octahydro-13H-[1,5]diazonino[7,8-g]furo[3,4-c]quinolin-13- one Step 1: A solution of methyl 7-chloro-4-((2,4-dimethoxybenzyl)amino)-1,3-dihydrofuro[3,4-c]quinoline-8-carboxylate 508a (1.0 g, 2.33 mmol), potassium trifluoro((methyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)amino)methyl)borate 508b (1.03 g, 3.50 mmol), caesium carbonate (2.28 g, 7.00 mmol), and CataCxiumA-Pd-G3 (169.81 mg, 0.23 mmol) in 1,4-dioxane (15 mL) and water (3 mL) was stirred at 100°C under nitrogen atmosphere for 4 hours. The reaction solution was filtered to remove solids, and the filtrate was diluted with ethyl acetate (250 mL), and washed with water and a sodium chloride aqueous solution. The organic phase was concentrated, and the residue was purified by silica gel column chromatography to obtain 508c (289 mg, yield: 21.4%). MS m / z (ESI): 580 [M+1]+ Step 2: 4 N hydrochloric acid (0.20 mL, 5.00 mmol) was added to a solution of 508c (550 mg, 0.95 mmol) in methanol (15 mL), and the mixture was stirred at 20°C for 2 hours. Upon completion of the reaction, the reaction system was quenched with a sodium bicarbonate solution, extracted with DCM, dried, and subjected to rotary evaporation to dryness and column chromatography to obtain 508d (460 mg, yield: 97.8%). MS m / z (ESI): 496 [M+1]+ Referring to the synthesis method described in Step 5 to Step 9 of Example 62, Example 508 (35.2 mg, yield: 8.0%) was obtained from 508d (460 mg, 0.93 mmol). MS m / z (ESI): 472 [M+1] + 1H NMR (400 MHz, DMSO-d6) 5 9.01 (br s, 1H), 8.27 (br d, 1 H), 8.05 - 7.56 (m, 3 H), 5.50 - 5.37 (m, 2 H), 5.21 - 4.86 (m, 4 H), 4.85 - 4.31 (m, 2 H), 3.25 - 2.96 (m, 4 H), 2.93 - 2.78 (m, 1 H), 2.74 - 2.63 (m, 4 H) ppm. Example 510 4-Amino-12-((5-(bicyclo[1.1.1]pentan-1-yl)pyridin-2-yl)methyl)-3,7,9,10,11,12- hexahydrofuro[3,4-c][1,5]oxazolo[7,8-g]quinolin-13(1H)-one Referring to the synthesis method described in Step 5 to Step 8 of Example 177, Example 510 (5 mg, yield: 1.2%) was obtained from (5-(bicyclo[1.1.1]pentan-1-yl)pyridin-2-yl)methanamine 510a (240 mg, 1.38 mmol) and methyl 7-((3-bromopropoxy)methyl)-4-(3,4-dimethoxybenzyl)amino)-1,3-dihydrofuro[3,4-c]quinoline-8-carboxylate 510b (500 mg, 0.92 mmol). MS m / z (ESI): 457 [M+1]+ 1H NMR (400 MHz, DMSO-d6)5 8.40 (d, 1H), 7.66 (dd, 1H), 7.50 (s, 1H), 7.44 (d, 1H), 7.35 (s, 1H), 6.63 (s, 2H), 5.34 (s, 2H), 5.18 (d, 1H), 5.01 (s, 2H), 4.68 (d, 1H), 4.55-4.45 (m, 2H), 4.21 (d, 1H), 3.73 (d, 1H), 3.13 (d, 3H), 2.57 (d, 1H), 2.152.04 (m, 7H). Example 514 4-Amino-8-methyl-12-((5-(trifluoromethyl)pyridin-2-yl)methyl)- 7,8,9,10,11,12-hexahydro-13H-azo[4,3-g]imidazo[1,5-a]quinoxalin-13-one Step 1: Trimethylaluminium (42.7 mL, 68.3 mmol, 1.6 M) was added dropwise to a solution of zirconocene dichloride (1.20 g, 4.11 mmol) in dichloromethane (34 mL) at -70°C under nitrogen atmosphere, and then deionised water (185 mg, 10.3 mmol) was added dropwise to the reaction solution. The reaction solution was stirred at -70°C for 0.5 hours, and then heated to room temperature and stirred for another 0.5 hours. The reaction solution was cooled to -70°C, and tert-butyl-dimethyl-4-ynyloxysilane (4.06 g, 20.47 mmol) was added dropwise to the reaction solution. The mixture was then heated to room temperature and stirred for 1.5 hours. The reaction solution was cooled to -70°C, and a solution of iodine (10.4 g, 40.98 mmol) in tetrahydrofuran (28 mL) was added dropwise to the reaction solution. The mixture was stirred at -70°C for 0.5 hours, and then heated to room temperature and stirred for another 1.5 hours. The reaction solution was slowly quenched with a sodium thiosulphate solution, and extracted with diethyl ether (100 mL x 3). The organic phases were combined and concentrated. The residue was purified by silica gel column chromatography to obtain 514b (5.30 g, yield: 76.1%). Step 2: n-Butyllithium (5.82 mL, 2.5 M) was added dropwise to a solution of 514b (3.30 g, 9.70 mmol) and 2,2'-bipyridine (76 mg, 0.48 mmol) in tetrahydrofuran (32 mL) at -70°C under nitrogen atmosphere. The reaction solution was stirred at -70°C for 0.5 hours. Triisopropyl borate (2.74 g, 14.55 mmol) was added dropwise to the reaction solution, and the mixture was heated to 0°C and stirred for 1 hour. The reaction solution was quenched with a saturated ammonium chloride aqueous solution, extracted with ethyl acetate (100 mL x 3), washed with a saturated sodium chloride aqueous solution (30 mL), dried over anhydrous sodium sulphate, filtered, and concentrated. The residue was purified by silica gel column chromatography to obtain 514c (1.50 g, yield: 59.9%). MS m / z (ESI): 259 [M+1]+ Step 3: Methyl 7-bromo-4-[(3,4-dimethoxyphenyl)methylamino]imidazo[1,5-a]quinoxaline-8-carboxylate (2.11 g, 4.47 mmol), 514c (1.50 g, 5.81 mmol), sodium carbonate (947 mg, 8.94 mmol) and 1,1'-bis(diphenylphosphino)ferrocene palladium(II) dichloride (327 mg, 0.45 mmol) were dissolved in water (3 mL) and dioxane (20 mL), and the mixture was purged three times with nitrogen, and stirred at 90°C for 2 hours. The reaction solution was concentrated, and the residue was purified by silica gel column chromatography to obtain 514d (2.10 g, yield: 77.7%). MS m / z (ESI): 605 [M+1]+ Step 4: 514d (2.00 g, 3.31 mmol) and tetrabutylammonium fluoride (6.61 mL, 1 M) were dissolved in tetrahydrofuran (10 mL). The reaction solution was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction solution was concentrated, and the residue was purified by silica gel column chromatography to obtain 514e (1.20 g, yield: 73.9%). MS m / z (ESI): 491 [M+1]+ Step 5: 514e (1.00 g, 2.04 mmol) and platinum dioxide (93 mg, 0.41 mmol) were dissolved in methanol (20 mL) and acetic acid (2.5 mL). The reaction solution was stirred at room temperature for 48 hours. Upon completion of the reaction, the reaction solution was filtered to remove solids and concentrated, and the residue was purified by silica gel column chromatography to obtain 514f (860 mg, yield: 85.6%). MS m / z (ESI): 493 [M+1]+ Step 6: A solution of carbon tetrabromide (1.02 g, 3.09 mmol) in dichloromethane (3 mL) was added dropwise to a solution of 514f (760 mg, 1.54 mmol) and triphenylphosphine (809 mg, 3.09 mmol) in dichloromethane (8 mL) at room temperature under nitrogen atmosphere. The reaction solution was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction solution was concentrated, and the residue was purified by silica gel column chromatography to obtain 514g (660 mg, yield: 77.0%). MS m / z (ESI): 555 [M+1]+ Referring to the synthesis method of Example 510, Example 514 (20 mg, yield:11.8%) was obtained from 514g (200 mg, 0.36 mmol). MS m / z (ESI): 469 [M+1]+ 1H NMR (400 MHz, MeOD) 3 9.25 (s, 1H), 8.89 (s, 1H), 8.35 (s, 1H), 8.22 (d, 1H), 8.16 (dd, 1H), 7.74 (d, 1H), 7.53 (s, 1H), 5.22...

Claims

1. A compound represented by general formula (I), or a stereoisomer or apharmaceutically acceptable salt thereof:M1 is selected from -N- or -CRa-;M2 is selected from -N- or -CRb-; preferably -CRb-;M3 is selected from N or C;ring A is selected from C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl; preferably C3-6 cycloalkyl, 3- to 6-membered heterocyclyl, phenyl or 5- to 6-membered heteroaryl;ring B is selected from C3-14 cycloalkyl, 3- to 14-membered heterocyclyl, C6-14 aryl or 5- to 14-membered heteroaryl; preferably C3-12 cycloalkyl, 3- to 12membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl; preferably C3-6 cycloalkyl, 3- to 6-membered heterocyclyl, C6-10 fused cycloalkyl, 6- to 10membered fused heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl;L1 is selected from a bond, -(CRaaRbb)m2-, -(CRaaRbb)m2C(O)-, -(CRaaRbb)m2C(S)-,     -(CRaaRbb)m2C(NRcc)-,     -(CRaaRbb)m2NRccC(O)-,     -(CRaaRbb)m2S(O)m1-,       -(CRaaRbb)m2NRcc-,       -(CRaaRbb)m2P(O)2-,       -(CRaaRbb)m2P(O)(ORcc)-, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-memberedheterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably -CRaaRbb-, -C(O)-, -S(O)m1- or -NRcc-;L2 is selected from a bond, -(CRaaRbb)m2-, -(CRaaRbb)m2C(O)-,  -(CRaaRbb)m2NRccC(O), -(CRaaRbb)m2S(O)m1- or -(CRaaRbb)m2NRcc-; preferably -CRaaRbb-, -C(O)-, -S(O)m1- or NRcc;R1 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, -(CRccRdd)n1-C3-12 cycloalkyl, -(CRccRdd)n1-3- to 12-membered heterocyclyl, -(CRccRdd)n1-C6-12 aryl, -(CRccRdd)n1-5- to 12-membered heteroaryl, -SF5, -ORe, -NReRf, -C(O)Re, -C(O)ORe, -C(O)NReRf, -N=S(O)ReRf, -S(O)Re(=NRf) or -P(O)ReRf, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl and =CRggRhh; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, -(CRccRdd)n1-C3-8 cycloalkyl, -(CRccRdd)n1-3- to 8membered heterocyclyl, -(CRccRdd)n1-C6-10 aryl, -(CRccRdd)n1-5- to 10-membered heteroaryl, -ORe, -NReRf, -C(O)Re, -C(O)NReRf or -P(O)ReRf, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;alternatively, R1 and Ra, Rb or Rc are connected to form C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably form C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;R2 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -(CH2)n2ORee, -(CH2)n2NReeRff, -(CH2)n2C(O)Ree, -(CH2)n2C(O)NReeRff, -(CH2)n2P(O)ReeRff or =CReeRff, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyanosubstituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10membered heteroaryl;R3 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -Y1-C3-12 cycloalkyl, -Y1-3- to 12-membered heterocyclyl, -Y1-C6-12 aryl, -Y1-5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh, -C(=NRi)NRgRh or =RgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5- to 12-membered heteroaryl and =CReRf; preferably hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh or =RgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5- to 12-membered heteroaryl and =CReRf;alternatively, any two R3, together with adjacent atoms to which they are attached, form C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably form C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyanosubstituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;Ra, Rb, Rc, Re and Rf are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -(CH2)n2ORee,  -(CH2)n2NReeRff, -(CH2)n2C(O)Ree, -(CH2)n2C(O)ORee, -(CH2)n2C(O)NReeRff,  -(CH2)n2N=S(O)ReeRff, -(CH2)n2S(O)Ree(=NRff) or -(CH2)n2P(O)ReeRff, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-memberedheterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl and =CRggRhh; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyanosubstituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;alternatively, Ra and Rb are connected to form C3-12 cycloalkyl, 3- to 12membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;Y1 is selected from a bond, -O-, -S-, -C(O), -NRj-, -C(O)NRj-, -NRjC(O)-, -S(O)2NRj-, -NRjS(O)2-, C1-6 alkylene, -O-C1-6 alkylene-, -C1-6 alkylene-O-, -NRj-C1-6 alkylene-, -C1-6 alkylene-NRj-, C2-6 alkenylene or C2-6 alkynylene, wherein the C1-6 alkylene, C2-6 alkenylene and C2-6 alkynylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;Rg, Rh, Ri and Rj are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl,cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;alternatively, Rg and Rh are connected to form C3-12 cycloalkyl, 3- to 12membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl, which are optionally further substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;Raa, Rbb, Rcc and Rdd are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-memberedheterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;Ree and Rff are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-memberedheterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;Rgg and Rhh are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-memberedheteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;x is selected from 0, 1, 2, 3, 4, 5 or 6;y is selected from 0, 1, 2, 3, 4, 5 or 6;m1 is selected from 0, 1 or 2;m2 is selected from 0, 1 or 2;n1 is selected from 0, 1, 2, 3 or 4; andn2 is selected from 0, 1, 2, 3 or 4.

2. The compound, or the stereoisomer or the pharmaceutically acceptablesalt thereof according to claim 1, characterised in that the     R1     is selectedfromor3.     A compound represented by general formula (A), or a stereoisomer ora pharmaceutically acceptable salt thereof:n8(A)M1 is selected from -N- or -CRa-;Ma is selected from CR2a, NR2a or N;Mb is selected from CR2b, NR2b or N;alternatively, R2a and R2b are connected to form ring A;ring A is selected from C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, which is optionally substituted with 0, 1, 2, 3, 4, 5 or 6 R2c;ring B is selected from C3-14 cycloalkyl, 3- to 14-membered heterocyclyl, C6-14 aryl or 5- to 14-membered heteroaryl;L2 is selected from a bond, -(CRaaRbb)m2-, -(CRaaRbb)m2C(O)-,  -(CRaaRbb)m2NRccC(O), -(CRaaRbb)m2S(O)m1- or -(CRaaRbb)m2NRcc-;L5 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  -(CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, =CR9aR9b, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;L6 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  -(CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, =CR9aR9b, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;L7 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  -(CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, =CR9aR9b, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;R2a is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;R2b is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;R2c is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -(CH2)n2ORee, -(CH2)n2NReeRff, -(CH2)n2C(O)Ree, -(CH2)n2C(O)NReeRff, -(CH2)n2P(O)ReeRff or =CReeRff, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl;R3 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh or =RgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5- to 12-membered heteroaryl and =CReRf;R9a and R9b are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;Ra is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -(CH2)n2ORee, -(CH2)n2NReeRff, -(CH2)n2C(O)Ree, -(CH2)n2C(O)NReeRff or -(CH2)n2P(O)ReeRff, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl;Rc is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -(CH2)n2ORee, -(CH2)n2NReeRff, -(CH2)n2C(O)Ree, -(CH2)n2C(O)NReeRff or -(CH2)n2P(O)ReeRff, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl;Re and Rf are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl;Rg and Rh are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl;RN is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl;Raa, Rbb and Rcc are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;Ree and Rff are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably hydrogen, deuterium, fluorine, chlorine, bromine, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, -C(O)-C1-3 alkyl, C3-8 cycloalkyl, 3-to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;y is selected from 0, 1, 2, 3, 4, 5 or 6;m1 is selected from 0, 1 or 2;m2 is selected from 0, 1 or 2;n2 is selected from 0, 1, 2, 3 or 4;n8 is selected from 0, 1, 2, 3 or 4;n9 is selected from 0, 1, 2, 3 or 4;n10 is selected from 0, 1, 2, 3 or 4.

4. The compound, or the stereoisomer or the pharmaceutically acceptablesalt thereof according to claim 1 or 3, characterised in that the compound is further a compound represented by general formula (III-E), or a stereoisomer or a pharmaceutically acceptable salt thereof:L6 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  -(CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, =CR9aR9b, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably a bond, -O-, -S-, -C(O), -NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; more preferably -O-, -S-, -C(O), -NRN-, C1-3 alkylene or C2-4 alkenylene, wherein the C1-3 alkylene and C2-4 alkenylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;L7 is selected from a bond, -O(CR9aR9b)n10-, -(CR9aR9b)n10O-, -S(CR9aR9b)n10-, -(CR9aR9b)n10S-, -C(O)(CR9aR9b)n10-, -(CR9aR9b)n10C(O)-,  -NRN(CR9aR9b)n10-,  -(CR9aR9b)n10NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, =CR9aR9b, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3-to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl; preferably a bond, -O-, -S-, -C(O), -NRN-, -C(O)NRN-, -NRNC(O)-, -S(O)2NRN-, -NRNS(O)2-, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene or 5- to 12-membered heteroarylene, wherein the C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, C3-12 cycloalkylene, 3- to 12-membered heterocyclylene, C6-12 arylene and 5- to 12-membered heteroarylene are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;n8 is selected from 0, 1, 2, 3 or 4; preferably 1, 2 or 3;n9 is selected from 0, 1, 2, 3 or 4; preferably 0, 1 or 2;n10 is selected from 0, 1, 2, 3 or 4;ring A, ring B, L2, M1, M3, Rc, R2, R3, x and y are as defined in claim 1.

5. The compound, or the stereoisomer or the pharmaceutically acceptablesalt thereof according to any one of claims 1-4, characterised in that the compound is further a compound represented by general formula (IV-E), or a stereoisomer or a pharmaceutically acceptable salt thereof:M5 is selected from N or CR3a;M6 is selected from N or CR3b;R5 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12membered heteroaryl;R3a, R3b, R3d and R3e are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh or -C(=NRi)NRgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5-to 12-membered heteroaryl and =CReRf;R3c is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl, 5- to 12-membered heteroaryl, -SF5, -ORg, -NRgRh, -C(O)Rg, -C(O)ORg, -C(O)NRgRh, -N=S(O)RgRh, -S(O)Rg(=NRh), -P(O)RgRh or -C(=NRi)NRgRh, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyanosubstituted C1-6 alkyl, substituted or unsubstituted C3-12 cycloalkyl, substituted or unsubstituted 3- to 12-membered heterocyclyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted 5- to 12-membered heteroaryl and =CReRf;L5, L6, L7, n8 and n9 are as defined in claim 3;ring A, M1, M3, Rc, R2 and x are as defined in claim 1.

6. The compound, or the stereoisomer or the pharmaceutically acceptablesalt thereof according to any one of claims 1-5, characterised in that ring A is selected from 3- to 12-membered heterocyclyl or 5- to 12-membered heteroaryl;5 preferably 5-membered heterocyclyl, 6-membered heterocyclyl, 5-memberedheteroaryl or 6-membered heteroaryl; more preferably7.     The compound, or the stereoisomer or the pharmaceutically acceptable15 salt thereof according to any one of claims 1-4, characterised in that ring B is selected from 3- to 6-membered heterocyclyl fused phenyl or 3- to 6-membered heterocyclyl\    / ~ N \fused 5- to 6-membered heteroaryl; preferably hn-- /     , HN— / alternatively, ring B is 6- to 14-membered tricyclic heterocyclyl; preferably 6-to 14-membered tricyclic spiro heterocyclyl or 6- to 14-membered tricyclic fusedheterocyclyl; more preferably108.     The compound, or the stereoisomer or the pharmaceutically acceptablesalt thereof according to any one of claims 1-7, characterised in that the compound is further as represented by general formula (VI-A) or (VI-B):n11 is selected from 0, 1 or 2.

9. The compound, or the stereoisomer or the pharmaceutically acceptablesalt thereof according to any one of claims 1-8, characterised in that each R2 or R2c is independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl or -C(O)NReeRff, wherein the amino, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, cyanosubstituted C1-3 alkyl and C3-8 cycloalkyl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, cyano-substituted C1-3 alkyl and C3-8 cycloalkyl;Ree and Rff are each independently selected from hydrogen, deuterium, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 hydroxyalkyl or cyano-substituted C1-3 alkyl;preferably hydrogen, deuterium, fluorine, chlorine, methyl, deuterated methyl,' / ^7        < / CNdifluoromethyl, trifluoromethyl, ^,^       or        ;Rc is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl or cyanosubstituted C1-3 alkyl; preferably hydrogen, deuterium, fluorine, chlorine, methyl, deuterated methyl, difluoromethyl or trifluoromethyl;Ra is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl or cyanosubstituted C1-3 alkyl; preferably hydrogen, deuterium, fluorine, chlorine, methyl, deuterated methyl, difluoromethyl or trifluoromethyl.

10. The compound, or the stereoisomer or the pharmaceutically acceptable salt thereof according to any one of claims 1-9, characterised in that R3 and R3c are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halogenated C1-3 alkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl, 5- to 10-membered heteroaryl or -SF5, wherein the amino, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halogenated C1-3 alkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;R3a, R3b, R3d and R3e are each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halogenated C1-3 alkoxy, C1-3 hydroxyalkyl,cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein the amino, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halogenated C1-3 alkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, 3- to 8-membered5 heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 1210 membered heteroaryl.

11. The compound, or the stereoisomer or the pharmaceutically acceptable salt thereof according to any one of claims 1-10, characterised in that the compoundhas the following structure:1555-256-55o                  o                  or o-..

12. A compound represented by general formula (A-I), or a stereoisomer or10 a pharmaceutically acceptable salt thereof: / Pgl( A-I )R’ is selected from hydrogen, C1-6 alkyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy or C1-6 hydroxyalkyl;R is selected from halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-R„R\ y6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl or                   ;R’’ is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, -C(O)-C1-6 alkyl, -C(O)O-C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl or 5- to 12-membered heteroaryl, wherein the amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl are optionally substituted with one or more substituents selected from deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, thio, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano-substituted C1-6 alkyl, C3-12 cycloalkyl, 3- to 12-membered heterocyclyl, C6-12 aryl and 5- to 12-membered heteroaryl;preferably a compound represented by general formula (A-II):,pgl(A-II)preferably, the compound represented by general formula (A-II) is further asrepresented by general formula (IV-E-I), general formula (IV-A-I) or generalformula (IV-B-I):Pg1 is selected from hydrogen, allyloxycarbonyl, trifluoroacetyl, tert-butylsulphinyl 2,4-dimethoxybenzyl, 3,5-dimethoxybenzyl, nitrobenzenesulphonyl, trityl, fluorenylmethoxycarbonyl, 9-fluorenylmethoxycarbonyl, benzyl, p-toluenesulphonyl, p-methoxybenzyl, formate, acetyl, benzyloxycarbonyl, phthaloyl, tert-butyloxycarbonyl or p-methoxyphenyl;Pg2 is selected from hydrogen, allyloxycarbonyl, trifluoroacetyl, tert-butylsulphinyl 2,4-dimethoxybenzyl, 3,5-dimethoxybenzyl, nitrobenzenesulphonyl, trityl, fluorenylmethoxycarbonyl, 9-fluorenylmethoxycarbonyl, benzyl, p-toluenesulphonyl, p-methoxybenzyl, formate, acetyl, benzyloxycarbonyl, phthaloyl, tert-butyloxycarbonyl or p-methoxyphenyl;M1, Ma, Mb, ring A, ring B, L2, L5, L6, L7, Ra, Rb, Rc, R3, n8, n9, x and y are as defined in any one of claims 3-7;M5, M6, R3a, R3b, R3c, R3d, R3e, R5 and n11 are as defined in claim 5 or 8.

13. The compound, or the stereoisomer or the pharmaceutically acceptable salt thereof according to claim 12, characterised in that the compound has the following structure:DMPM-269-DMPMDMPMBrDMPMDMPMor14. A method for preparing a compound represented by general formula(A), or a stereoisomer or a pharmaceutically acceptable salt thereof, characterised inthatPgl                                                 / Pgl( A-II )H,NnX(A)10a compound represented by general formula (A-I) is reacted in the presence of a condensing agent and a base to obtain a compound represented by general formula (A-II), which is further deprotected to obtain the compound represented by general formula (A);preferably, the method is a method for preparing a compound represented by general formula (IV-E), or a stereoisomer or a pharmaceutically acceptable salt thereof:15(IV-E )a compound represented by general formula (IV-E-I) is reacted in the presence of a condensing agent and a base to obtain a compound represented by general formula (IV-E-II), which is further deprotected to obtain the compound represented by general formula (IV-E);alternatively, the method is a method for preparing a compound represented by general formula (VI-A), or a stereoisomer or a pharmaceutically acceptable salt thereof:a compound represented by general formula (VI-A-I) is reacted in the presence of a condensing agent and a base to obtain a compound represented by general formula (VI-A-II), which is further deprotected to obtain the compound represented by general formula (VI-A);alternatively, the method is a method for preparing a compound represented by general formula (VI-B), or a stereoisomer or a pharmaceutically acceptable salt thereof:a compound represented by general formula (VI-B-I) is reacted in the presence of a condensing agent and a base to obtain a compound represented by general formula (VI-B-II), which is further deprotected to obtain the compound represented by general formula (VI-B);Pg1 is selected from hydrogen, allyloxycarbonyl, trifluoroacetyl, tert-butylsulphinyl 2,4-dimethoxybenzyl, 3,5-dimethoxybenzyl, nitrobenzenesulphonyl, trityl, fluorenylmethoxycarbonyl, 9-fluorenylmethoxycarbonyl, benzyl, p-toluenesulphonyl, p-methoxybenzyl, formate, acetyl, benzyloxycarbonyl, phthaloyl, tert-butyloxycarbonyl or p-methoxyphenyl;Pg2 is selected from hydrogen, allyloxycarbonyl, trifluoroacetyl, tert-butylsulphinyl 2,4-dimethoxybenzyl, 3,5-dimethoxybenzyl, nitrobenzenesulphonyl, trityl, fluorenylmethoxycarbonyl, 9-fluorenylmethoxycarbonyl, benzyl, p-toluenesulphonyl, p-methoxybenzyl, formate, acetyl, benzyloxycarbonyl, phthaloyl, tert-butyloxycarbonyl or p-methoxyphenyl;M1, Ma, Mb, ring A, ring B, L2, L5, L6, L7, Ra, Rb, Rc, R3, n8, n9, x and y are as defined in any one of claims 3-7;M5, M6, R3a, R3b, R3c, R3d, R3e, R5 and n11 are as defined in claim 5 or 8.

15. A pharmaceutical composition, characterised by comprising a therapeutically effective dose of the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof according to any one of claims 1-11, and one or more pharmaceutically acceptable carriers, diluents, or excipients.

16. Use of the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof according to any one of claims 1-11, or the pharmaceutical composition according to claim 15 in the preparation of a PRMT5 inhibitor drug.

17. Use of the compound, or the stereoisomer or the pharmaceutically acceptable salt thereof according to any one of claims 1-11, or the pharmaceutical composition according to claim 15 in the preparation of a drug for the treatment of a cancer.

18. The use according to claim 17, characterised in that the cancer is selected from lung cancer, hepatocellular carcinoma, breast cancer, skin cancer, bladder cancer, liver cancer, pancreatic cancer, head and neck cancer, glioma, glioblastoma, oesophageal cancer, pancreatic cancer, mesothelioma, melanoma, astrocytoma, undifferentiated pleomorphic sarcoma, leukaemia, gastric adenocarcinoma, myxofibrosarcoma, cholangiosarcoma, brain cancer, gastric cancer, renal cancer, endometrial cancer, ovarian tumour, prostate cancer, diffuse large B-cell lymphoma, non-Hodgkin lymphoma, urinary tract cancer, soft tissuecancer, pleural cancer, large intestine cancer, colourectal cancer, biliary tract cancer or cholangiocarcinoma; the lung cancer is selected from non-small cell lung cancer, lung squamous cell carcinoma or lung adenocarcinoma; the oesophageal cancer is selected from oesophageal squamous cell carcinoma or oesophageal5 adenocarcinoma.