Compositions and methods for treating bile acid malabsorption
A high-drug-load, gastro-resistant colesevelam formulation targets the ileum and colon, addressing patient compliance and drug interaction issues in treating bile acid malabsorption and diarrhea.
Patent Information
- Authority / Receiving Office
- AU · AU
- Patent Type
- Applications
- Current Assignee / Owner
- COSMO TECHNOLOGIES LTD
- Filing Date
- 2025-01-31
- Publication Date
- 2026-07-16
AI Technical Summary
Current bile acid sequestrants for treating bile acid malabsorption and diarrhea have low patient compliance due to high doses, adverse reactions, and unspecific drug interactions, as they release in the upper gastrointestinal tract, affecting the absorption of bile acids and other medications.
A pharmaceutical composition with a high drug load of colesevelam or its salt, coated for gastro-resistant release primarily in the ileum and colon, reducing the number of daily administrations and minimizing interference with bile acid function and other drug absorption.
Enhances patient compliance by reducing the frequency of doses and targeting bile acids in the colon, minimizing adverse reactions and drug interactions, while maintaining effective treatment of bile acid malabsorption and diarrhea.
Smart Images
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