Continuous chromatography system and chromatography method

Abstract

The invention discloses a continuous chromatography system and a chromatography method. The system comprises a first chromatography module, a first receiving device, a rapid concentration module, a second chromatography module, a second liquid storage module and a third receiving device; the first chromatography module defines a first chromatography space, and a second liquid inlet is connected with a first flow speed control device of a first liquid storage module; a first detection device is connected to the first receiving device; the rapid concentration module is provided with a third liquid inlet which is connected with the first receiving device, and the lower end of the rapid concentration module is connected with the second receiving device; the second chromatography module defines a second chromatography space, a fourth liquid inlet and a fourth liquid outlet are formed in the upper end and the lower end of the second chromatography space, and the fourth liquid inlet is connected with a third liquid outlet of the second receiving device; the second liquid storage module is provided with a fifth liquid outlet, and the fifth liquid outlet is provided with a second flow speed control device and connected with the fifth liquid outlet of the second liquid storage module; the third receiving device is connected with the fourth liquid outlet. By means of the device, close joining of the previous chromatography process and the next chromatography process can be achieved, and the overall chromatography efficiency is improved through online linkage.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical or chemical synthesis, and specifically relates to a continuous chromatography system and a chromatography method. Background technique

[0002] Column chromatography is a common separation and purification method in the field of pharmaceutical or chemical synthesis. In view of the physical properties of substances, especially for natural products, more than two chromatography processes with different fillers are often required to achieve the separation effect. In the prior art, a rotary evaporator is usually used to concentrate the liquid collected from the previous chromatography, and then to perform further chromatography, which takes a long time and affects the efficiency of the experiment.

[0003] Therefore, continuous chromatography systems and chromatography methods still need to be further improved. Contents of the invention

[0004] The present invention aims at solving one of the techni...

Examples

Embodiment Construction

[0033] Embodiments of the present invention are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals designate the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary and are intended to explain the present invention and should not be construed as limiting the present invention.

[0034] In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Back", "Left", "Right", "Vertical", "Horizontal", "Top", "Bottom", "Inner", "Outer", "Clockwise", "Counterclockwise", "Axial" , "radial", "circumferential" and other indicated orientations or positional relationships are based on the orientations or positional relationships shown in the drawings, which are only for the convenience of describing the ...

technical field

[0001] The invention belongs to the field of pharmaceutical or chemical synthesis, and specifically relates to a continuous chromatography system and a chromatography method. Background technique

[0002] Column chromatography is a common separation and purification method in the field of pharmaceutical or chemical synthesis. In view of the physical properties of substances, especially for natural products, more than two chromatography processes with different fillers are often required to achieve the separation effect. In the prior art, a rotary evaporator is usually used to concentrate the liquid collected from the previous chromatography, and then to perform further chromatography, which takes a long time and affects the efficiency of the experiment.

[0003] Therefore, continuous chromatography systems and chromatography methods still need to be further improved. Contents of the invention

[0004] The present invention aims at solving one of the techni...

Examples

Embodiment Construction

[0033] Embodiments of the present invention are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals designate the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary and are intended to explain the present invention and should not be construed as limiting the present invention.

[0034] In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Back", "Left", "Right", "Vertical", "Horizontal", "Top", "Bottom", "Inner", "Outer", "Clockwise", "Counterclockwise", "Axial" , "radial", "circumferential" and other indicated orientations or positional relationships are based on the orientations or positional relationships shown in the drawings, which are only for the convenience of describing the ...

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