A neutron irradiation therapy module for a medical ship

Abstract

The present invention belongs to the technical field of radioactive irradiation therapy, and specifically relates to a neutron irradiation therapy module for a medical ship, which is arranged on the medical ship. The neutron irradiation therapy module is a cubic cabin, which is divided into four layers from bottom to top. The vertically arranged cylindrical reactor body and water pool are located in the center of the neutron irradiation therapy module, and run through the space from the first layer to the fourth layer; the first layer located at the bottom is provided with an observation room, a mixed beam irradiation room and an epithermal beam irradiation room, the second layer is provided with a loading and unloading transportation channel, the third layer is provided with a reactor main control room and a reactor hall, and the top fourth layer is provided with a transfer crane. On the basis of meeting the requirements of nuclear radiation protection, the neutron irradiation therapy module realizes the arrangement of personnel flow, logistics and emergency escape channels in combination with the module space size and the hull structure, realizes the radioactive zoning management of activities such as operation, maintenance, material replacement and spent fuel transportation during the service of the reactor, and ensures the evacuation of personnel in an emergency state.

Description

Technical Field

[0001] The invention belongs to the technical field of radioactive irradiation therapy, and in particular relates to a neutron irradiation therapy module for a medical ship. Background Art

[0002] Boron neutron capture therapy (BNCT) is a biological targeted radiotherapy mode with "inherent" safety. Non-toxic boron-containing drugs with affinity for tumor tissue are injected into the patient's body. After the drugs are enriched in the tumor tissue, thermal neutrons or epithermal neutrons are used to irradiate the tumor site. Neutrons and boron-10 nuclides in cancer cells come into contact and undergo nuclear reactions. The released He ions and Li ions move in opposite directions, and their energy is sufficient to kill cancer cells with minimal side effects. At present, the neutron sources used for BNCT mainly include nuclear reactor neutron sources and accelerator-based neutron sources. Compared with accelerator-based neutron sources, nuclear reactor neutron source devices are smaller in size and have lower investment costs. They are the neutron sources with the most BNCT systems currently in use internationally.

[0003] At the end of the 20th century, Academician Zhou Yongmao developed a hospital neutron irradiator for cancer treatment using the principle of neutron capture therapy. It is a low-concentration UO2 core, light water cooling and moderation, a pool-type neutron source with a metal beryllium full reflector, equipped with two irradiation beams in different neutron energy ranges, and can provide two patients with clinical treatment at the same time. It is a miniature, safe, economical and efficient advanced cancer treatment device. In early 2010, the hospital neutron irradiator type 1 was built in Beijing, with a reactor power of 30kW and two neutron beams, one for thermal neutron beams used for biomedical research and treatment of superficial human tumors, and the other for epithermal neutron beams used for clinical treatment of deeper human cancers. Various preparatory experimental studies on preclinical irradiation of cancer patients are now being carried out.

[0004] The application of neutron irradiation therapy on medical ships is to equip the medical ships with complete neutron capture therapy special medical neutron irradiators and high-end conventional radiotherapy machines. The medical ships mainly include engine rooms, driving rooms, living quarters, conventional treatment modules and neutron irradiation therapy modules, among which the neutron source device of the neutron irradiation therapy module adopts the built hospital neutron irradiator, but the existing model of the neutron irradiator is a land-based reactor. Obviously, its external structure and the overall layout of various process systems cannot be copied and used. It is necessary to combine the overall design of the hull and consider the factors such as the construction, operation, maintenance and refueling of the reactor on board to carry out adaptive transformation and layout optimization. Summary of the invention

[0005] The purpose of the present invention is to provide a neutron irradiation therapy module that can be used in a medical ship based on the existing conventional medical ship and in combination with the structure and layout of the hull. The module ensures the reliability of the neutron irradiation therapy function and meets the requirements of the hull structure strength, ship nuclear safety and radiation protection. In a compact and limited space, it not only realizes the arrangement of personnel flow, logistics and emergency escape passages, but also realizes the radioactive zoning management of activities such as operation, maintenance, refueling and spent fuel transportation of the reactor during service, and ensures the evacuation of personnel in emergency (nuclear, fire and water ingress) conditions.

[0006] To achieve the above purpose, the technical solution adopted by the present invention is a neutron irradiation therapy module for a medical ship, which is arranged on the medical ship, wherein the neutron irradiation therapy module is a cubic cabin, which is divided into four layers from bottom to top, and the vertically arranged cylindrical reactor body and water pool are located in the center of the neutron irradiation therapy module, running through the space from the first layer to the fourth layer; the first layer located at the bottom is provided with an observation room, a mixed beam irradiation room and an epithermal beam irradiation room, the second layer is provided with a loading and unloading transportation channel, the third layer is provided with a reactor main control room and a reactor hall, and the top fourth layer is provided with a transfer crane.

[0007] Furthermore, a waste liquid and waste resin storage room is also provided in the first floor; the mixed beam irradiation room and the superheated beam irradiation room are symmetrically arranged on both sides of the stack body and the water pool, and the observation room and the waste liquid and waste resin storage room are symmetrically arranged on the other two sides of the stack body and the water pool; the observation room is also provided with a direct elevator connected to the hull of the medical ship and a staircase leading to the upper floor.

[0008] Furthermore, a bath water collection room, a spare parts and tool storage room, an air supply and air conditioning system process room, an air and water purification system process room, and a staircase leading to the upper floor are also provided on the second floor; the bath water collection room and the spare parts and tool storage room are located above the observation room, the air supply and air conditioning system process room is located above the mixed beam irradiation room, the air and water purification system process room is located above the superheated beam irradiation room, the loading and unloading transportation channel is located above the waste liquid and waste resin storage room and is provided with a reserved unloading door connected to the hull of the medical ship.

[0009] Furthermore, in the third floor, the reactor body and the water pool are located in the reactor hall, and the floor of the reactor hall is provided with a material replacement and unloading channel cover plate which is connected to the loading and unloading and transportation channel; the third floor is also provided with a sanitary passage, an exhaust system process room, and a control cabinet room; a shower room is provided in the sanitary passage, and the shower room is located above the shower water collection room; it also includes a toilet located above the spare parts and tool storage room; the reactor main control room is located above the gas and water purification system process room, and the control cabinet room is located inside the reactor main control room and is connected to the reactor main control room; it also includes stairs leading to the upper floor.

[0010] Furthermore, in the fourth floor, the part located above the reactor hall is connected to the reactor hall; the part located above the exhaust system process room is connected to the exhaust system process room; the transfer crane can operate above the reactor hall; and it also includes a chimney gas monitoring equipment room above the stairs connecting the third floor with the second floor and a radiation measurement room above the reactor main control room.

[0011] Furthermore, an entrance and exit for reactor workers is provided on the bulkhead near the toilet on the third floor; an emergency escape door connected to the hull is provided on the bulkhead near the staircase connecting the third floor with the second floor.

[0012] Furthermore, an emergency passage connected to the hull is also provided on the fourth floor. The emergency passage is located above the sanitary passage and the stairs connecting the third floor and the fourth floor. An emergency escape door connected to the hull is provided on the bulkhead next to the emergency passage.

[0013] The beneficial effects of the present invention are:

[0014] The overall arrangement of the neutron irradiation therapy module on the medical ship, while meeting the requirements of nuclear radiation protection, combines the module space size and hull structure to achieve the arrangement of personnel, logistics and emergency escape passages, and can also realize the radioactive zoning management of activities such as operation, maintenance, material replacement and spent fuel transportation of the reactor during service, and ensure the evacuation of personnel in emergency (nuclear, fire and water ingress) conditions. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 is a schematic diagram of the first layer of a neutron irradiation therapy module for a medical ship according to a specific embodiment of the present invention;

[0016] Figure 2 is a schematic diagram of the second layer of a neutron irradiation therapy module for a medical ship according to a specific embodiment of the present invention;

[0017] Figure 3 is a schematic diagram of the third layer of a neutron irradiation therapy module for a medical ship according to a specific embodiment of the present invention;

[0018] Figure 4 is a schematic diagram of the fourth layer of a neutron irradiation therapy module for a medical ship according to a specific embodiment of the present invention;

[0019] Figure 5 It is a three-dimensional schematic diagram of a neutron irradiation therapy module for a medical ship described in a specific embodiment of the present invention;

[0020] Figure 6 It is a schematic diagram of a neutron irradiation therapy module for a medical ship according to a specific embodiment of the present invention being arranged on a medical ship;

[0021] In the figure: 1-neutron irradiation therapy module, 2-living deck, 3-main deck (upper deck), 4-lower deck, 5-platform deck, 6-double bottom, 7-through elevator, 8-observation room, 9-mixed beam irradiation room, 10-reactor body and water pool, 11-superheated beam irradiation room, 12-waste liquid and waste resin storage room, 13-bath water collection room, 14-spare parts and tool storage room, 15-air supply and air conditioning system process room, 16-air and water purification system process room, 17-loading and unloading Material transportation channel, 18-toilet, 19-shower room, 20-sanitary channel, 21-exhaust system process room, 22-reactor main control room, 23-reactor hall, 24-replacement and unloading channel cover, 25-control cabinet room, 26-emergency channel, 27-chimney gas monitoring equipment room, 28-radiation measurement room, 29-transfer crane, 30-reactor staff entrance and exit, 31-medical and patient elevator entrance, 32-emergency escape door, 33-reserved door for unloading. DETAILED DESCRIPTION

[0022] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0023] The present invention provides a neutron irradiation therapy module for a medical ship, which is arranged on the medical ship, wherein the neutron irradiation therapy module 1 is a cubical cabin (such as Figures 1 to 5 As shown in FIG. 1 , it is divided into four layers from bottom to top. The vertically arranged cylindrical stack body and water pool 10 are located at the center of the neutron irradiation therapy module 1 and run through the space from the first layer to the fourth layer.

[0024] The first layer Figure 1As shown, the first floor located at the bottom is provided with a through elevator 7, an observation room 8, a mixed beam irradiation room 9, an epithermal beam irradiation room 11, a waste liquid and waste resin storage room 12 and corresponding personnel passages, and also includes a medical and patient elevator entrance 31 and a staircase leading to the upper floor. The reactor active area is located in this floor. The mixed beam irradiation room 9 and the epithermal beam irradiation room 11 are symmetrically arranged on both sides of the reactor body and the water pool 10, and the observation room 8 and the waste liquid and waste resin storage room 12 are symmetrically arranged on the other two sides of the reactor body and the water pool 10; the through elevator 7 and the staircase leading to the upper floor are arranged in the observation room 8, and the medical and patient elevator entrance 31 is connected to the hull of the medical ship, so that personnel can enter the through elevator 7 from the medical ship and then enter the neutron irradiation therapy module 1. The observation room 8, the mixed beam irradiation room 9 and the epithermal beam irradiation room 11 are equipped with relevant medical equipment for irradiation therapy activities according to medical requirements. The waste liquid and waste resin storage room 12 is used for storing waste liquid and waste resin storage tanks. The waste liquid and waste resin are transported to the storage tanks through prefabricated pipelines.

[0025] The second layer Figure 2 As shown, the second floor is also provided with a bath water collection room 13, a spare parts and tool storage room 14, an air supply and air conditioning system process room 15, an air-water purification system process room 16, a loading and unloading material transportation channel 17 and corresponding personnel channels, and also includes a staircase leading to the upper floor; the bath water collection room 13 and the spare parts and tool storage room 14 are located above the observation room 8, the air supply and air conditioning system process room 15 is located above the mixed beam irradiation room 9, the air-water purification system process room 16 is located above the super-heat beam irradiation room 11, and the loading and unloading material transportation channel 17 is located above the waste liquid and waste resin storage room 12 and is provided with a reserved unloading door 33 connected to the hull of the medical ship. The air-water purification system process room 16 is used for the layout of the loop equipment and pipelines of the reactor water, reactor gas and pool water purification system to ensure that the reactor water, reactor gas and pool water meet the operation requirements and reduce the radioactivity level. The bath water collection room 13 is provided with a collection tank. The bath water collected in the collection tank is monitored and discharged directly according to its radioactivity level or transferred through pipelines to the waste liquid collection tank of the first-layer waste liquid and waste resin storage room 12 for temporary storage. The air supply and air conditioning system process room 15 is used for the arrangement of air supply and air conditioning equipment in the neutron irradiation therapy module 1. The loading and unloading transportation channel 17 connects the neutron irradiation therapy module 1 and the entire medical ship. The channel is arranged with necessary equipment such as transport rails, electric-driven transport vehicles, and monitoring cameras, which can realize the remote operation of the transportation of spent fuel and other solid waste. The unloading reserved door 33 is used to realize the transportation of spent fuel from the reactor and other solid radioactive waste generated by the overhaul and maintenance of the reactor.

[0026] The third layer Figure 3As shown, the third floor is provided with a toilet 18, a shower room 19, a sanitary passage 20, an exhaust system process room 21, a reactor main control room 22, a reactor hall 23, a control cabinet room 25 and corresponding personnel passages, and also includes a staircase leading to the upper floor; on the third floor, the reactor body and the water pool 10 are located in the reactor hall 23, and the floor of the reactor hall 23 is provided with a material replacement and unloading passage cover 24 that communicates with the loading and unloading and transportation passage 17 on the second floor; the shower room 19 is arranged in the sanitary passage 20, and the shower room 19 is located above the shower water collection room 13; the toilet 18 is located in the spare parts and tool storage room 1 4; the reactor main control room 22 is located above the gas-water purification system process room 16, and the control cabinet room 25 is located inside the reactor main control room 22 and communicates with the reactor main control room 22; on the bulkhead near the toilet 18 on the third floor, there is a reactor staff entrance and exit 30 for the reactor operation and maintenance personnel (staff) to enter and exit; on the bulkhead near the stairs connecting the third floor and the second floor, there is an emergency escape door 32 connected to the hull (the emergency escape door is located in the sanitary passage 20), which is used to meet the emergency escape needs of the personnel in the module in the event of a fire or water ingress emergency. The reactor main control room 22 is the operation center of the neutron irradiation therapy module 1, which is used for the operation, monitoring and operation of the reactor. The reactor main control room 22 is arranged with a reactor operating console, a monitoring and protection operation terminal, a printer and other equipment. A lead glass window is provided between the reactor main control room 22 and the reactor hall 23. The control cabinet room 25 is used for the installation and layout of the reactor control and protection system cabinets. The reactor hall 23 is the reactor top operation hall. A transfer crane 29 is provided on the top of the reactor hall 23 on the fourth floor. By opening the cover plate 24 of the material exchange and unloading passage on the floor of the reactor hall 23, the reactor hall 23 can be connected to the loading and unloading transportation passage 17 on the second floor. The transfer crane 29 can complete the outward transportation of spent fuel and solid waste. The exhaust system process room 21 and the air supply and air conditioning system process room 15 jointly realize the arrangement of ventilation and air conditioning equipment in the neutron irradiation therapy module 1. In addition to the bathroom 19, the sanitary passage 20 is also provided with a personal dosimeter storage area, a changing area and a one-way gate. After the operation and maintenance personnel change the work clothes in the radioactive area, they can enter the reactor supervision area through the one-way gate to perform maintenance and other operations. After the operation is completed, the contamination meter at the door of the bathroom 19 is used to check whether there is contamination to determine whether it is necessary to take a bath to remove contamination, or change clothes to return to the non-restricted area. The toilet 18 is set in the non-restricted area of ​​this floor.

[0027] The fourth layer Figure 4As shown, in the fourth floor, the part located above the reactor hall 23 is connected to the reactor hall 23 and serves as the top of the reactor hall 23; the part located above the exhaust system process room 21 is connected to the exhaust system process room 21 and serves as the top of the exhaust system process room 21; it also includes a transfer crane 29 that can run above the reactor hall 23; it also includes a chimney gas monitoring equipment room 27 located above the staircase connected to the second floor on the third floor and a radiation measurement room 28 located above the reactor main control room 22, and the radiation measurement room 28 is used to install radiation monitoring system equipment, such as system monitoring host, sampling and analysis equipment, etc. In the fourth floor, an emergency passage 26 connected to the hull is also provided, and the emergency passage 26 is located above the sanitary passage 20 and the staircase connected to the third floor and the fourth floor. An emergency escape door 32 connected to the hull is provided on the bulkhead next to the emergency passage 26, which is used to meet the emergency escape needs of personnel in the module in the event of a fire or water ingress emergency.

[0028] The following example illustrates the application of a neutron irradiation therapy module for a medical ship provided by the present invention on a medical ship:

[0029] like Figure 6 As shown, the medical ship mainly includes the engine room, the wheelhouse, the living area, the conventional treatment module and the neutron irradiation treatment module 1. The medical ship is generally composed of the platform deck 5, the lower deck 4, the main deck 3 (upper deck) and the living deck 2, wherein the neutron irradiation treatment module 1 runs through the above four decks, and the module is divided into four major layers (if the height of the hull is insufficient, the fourth layer is used as the mezzanine of the third layer; if the height of the hull is high enough, the mezzanine is layered separately as the fourth layer) to arrange various process systems, the first layer is located on the double bottom 6 of the hull, the third layer is flush with the main deck 3 of the hull (the emergency escape door 32 of the third layer is connected to the main deck 3, and the reactor staff entrance and exit 30 is flush with the main deck 3), and the fourth layer (i.e., the third layer mezzanine) is flush with the living deck 2 (the emergency escape door 32 of the fourth layer is connected to the living deck 2).

[0030] The device described in the present invention is not limited to the embodiments described in the specific implementation manner. Those skilled in the art may derive other implementation manners based on the technical solution of the present invention, which also fall within the technical innovation scope of the present invention.

Claims

1. A neutron irradiation therapy module for a medical ship, arranged on the medical ship, characterized in that: The neutron irradiation therapy module (1) is a cubic cabin, which is divided into four layers from bottom to top. A vertically arranged cylindrical reactor body and a water pool (10) are located at the center of the neutron irradiation therapy module (1) and run through the space from the first layer to the fourth layer. The first layer located at the bottom is provided with an observation room (8), a mixed beam irradiation room (9) and an epithermal beam irradiation room (11), the second layer is provided with a loading and unloading transportation channel (17), the third layer is provided with a reactor main control room (22) and a reactor hall (23), and the top fourth layer is provided with a transfer crane (29).

2. The neutron irradiation therapy module for a medical ship according to claim 1, characterized in that: The first layer is also provided with a waste liquid and waste resin storage room (12); the mixed beam irradiation room (9) and the superheated beam irradiation room (11) are symmetrically arranged on both sides of the stack body and the water pool (10); the observation room (8) and the waste liquid and waste resin storage room (12) are symmetrically arranged on the other two sides of the stack body and the water pool (10); the observation room (8) is also provided with a direct elevator (7) connected to the hull of the medical ship and a staircase leading to the upper layer.

3. The neutron irradiation therapy module for a medical ship as claimed in claim 2, characterized in that: The second floor is also provided with a bath water collection room (13), a spare parts and tool storage room (14), an air supply and air conditioning system process room (15), and an air-water purification system process room (16), and also includes a staircase leading to the upper floor; the bath water collection room (13) and the spare parts and tool storage room (14) are located above the observation room (8), the air supply and air conditioning system process room (15) is located above the mixed beam irradiation room (9), the air-water purification system process room (16) is located above the superheated beam irradiation room (11), and the loading and unloading transportation channel (17) is located above the waste liquid and waste resin storage room (12) and is provided with a reserved unloading door (33) connected to the hull of the medical ship.

4. The neutron irradiation therapy module for a medical ship as claimed in claim 3, characterized in that: In the third floor, the reactor body and the water pool (10) are located in the reactor hall (23), and the floor of the reactor hall (23) is provided with a material replacement and unloading channel cover plate (24) which is communicated with the loading and unloading transportation channel (17); the third floor is also provided with a sanitary passage (20), an exhaust system process room (21), and a control cabinet room (25); a shower room (19) is provided in the sanitary passage (20), and the shower room (19) is located above the shower water collection room (13); it also includes a toilet (18) located above the spare parts and tool storage room (14); the reactor main control room (22) is located above the gas and water purification system process room (16), and the control cabinet room (25) is located inside the reactor main control room (22) and communicated with the reactor main control room (22); it also includes a staircase leading to the upper floor.

5. The neutron irradiation treatment module for a medical ship as claimed in claim 4, characterized in that: In the fourth floor, the portion located above the reactor hall (23) is connected to the reactor hall (23); the portion located above the exhaust system process room (21) is connected to the exhaust system process room (21); the transfer crane (29) is capable of operating above the reactor hall (23); and it also includes a chimney gas monitoring equipment room (27) located above the stairs connecting the third floor and the second floor, and a radiation measurement room (28) located above the reactor main control room (22).

6. The neutron irradiation therapy module for a medical ship as claimed in claim 4, characterized in that: An entrance and exit (30) for reactor workers is provided on the bulkhead near the toilet (18) on the third floor; an emergency escape door (32) connected to the hull is provided on the bulkhead near the staircase connecting the third floor and the second floor.

7. The neutron irradiation therapy module for a medical ship as claimed in claim 5, characterized in that: The fourth floor is also provided with an emergency passage (26) connected to the hull. The emergency passage (26) is located above the sanitary passage (20) and the stairs connecting the third floor and the fourth floor. An emergency escape door (32) connected to the hull is provided on the bulkhead next to the emergency passage (26).

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