A silicon body delivery system for targeting and activating CD44 molecules, its preparation method and use

A technology of delivery system and siliceous body, which can be applied in the directions of liposome delivery, cardiovascular system diseases, medical preparations containing active ingredients, etc., and can solve problems such as nonexistence

CN110402137BActive Publication Date: 2021-03-09BEIJING INNO MEDICINE CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2021-03-09

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Abstract

A silicon body delivery system for targeting activated CD44 molecules, a preparation method and use thereof, the surface of the silicon body is partially modified by a targeting ligand, and the targeting ligand is capable of interacting with the activated The ligand to which the CD44 molecule specifically binds. The silica body delivery system can be used for the diagnosis, prevention and treatment of vulnerable plaques or diseases related to vulnerable plaques.
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Description

technical field

[0001] The invention belongs to the technical field of targeted drug delivery, and in particular relates to a silicon body delivery system for targeting and activating CD44 molecules, especially vulnerable plaques. The present invention also relates to the preparation method and use of the silicon body delivery system, especially the use in the diagnosis, prevention and treatment of vulnerable plaques or diseases related to vulnerable plaques. Background technique

[0002] At present, acute cardiovascular events, mainly acute myocardial infarction and sudden cardiac death, have become the number one killer of human health. According to statistics, about 20 million people die of acute cardiovascular events in the world every year. In China, the situation is also not optimistic. More than 700,000 people die of acute myocardial infarction and sudden cardiac death every year, which has become one of the most important diseases that seriously threaten the health ...

Examples

Embodiment Construction

[0042] According to one aspect of the present invention, the present invention provides a silicon body delivery system for targeting activated CD44 molecules, the surface of the silicon body is partially modified by a targeting ligand, and the targeting ligand It is a ligand that can specifically bind to activated CD44 molecules.

[0043] According to one aspect of the present invention, the present invention provides a silicon body delivery system for targeting vulnerable plaques, the surface of the silicon body is partially modified by a targeting ligand, and the targeting ligand It is a ligand that can specifically bind to CD44 molecules on the surface of cells at vulnerable plaques.

[0044] According to one aspect of the present invention, the present invention provides a silicon body delivery system for targeting vulnerable plaques, wherein the silicon body delivery system comprises silicon body vesicles, wherein the silicon body The surface of plastid vesicles is parti...