A wet granulation device

Abstract

The invention discloses a wet granulation device, which can fully atomize an adhesive, has a large atomization area, and has a good atomization effect. A wet granulation device comprises a granulator container and a granulator pot cover, wherein a stirring assembly is arranged at the bottom of the granulator container, a cutting assembly is arranged radially on one side of the granulator container, a two-flow atomizer is arranged on the granulator pot cover, the two-flow atomizer has a liquid nozzle and a gas nozzle, the two-flow atomizer is respectively connected to a liquid circuit assembly and a gas circuit assembly, the liquid circuit assembly is connected to the liquid nozzle, the gas circuit assembly is connected to the gas nozzle, the gas nozzle is annular and surrounds the liquid nozzle, the liquid circuit assembly is used to input the adhesive, and the gas circuit assembly is used to input the gas for atomizing the adhesive.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical equipment, in particular to a wet granulation device. Background Art

[0002] At present, the wet granulator needs to fully mix the powdered drug and adhesive in the container by the bottom mixing paddle (stirring component) at high speed to form a wet soft material, and then cut it into uniform particles by the side high-speed crushing paddle (cutting component) to achieve the purpose of granulation.

[0003] However, the existing wet granulation devices generally use methods such as scooping, gravity inflow through a funnel, and simple nozzles to process adhesives. The adhesives are easy to accumulate in one place, and the adhesives cannot be effectively dispersed or atomized, resulting in uneven drug granulation, unstable drug particle content, easy stratification and cracking, which reduces the quality of drug particles and even affects the effect of drug use. Summary of the invention

[0004] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a wet granulation device which can fully atomize the adhesive, has a large atomization area and a good atomization effect.

[0005] The object of the present invention is achieved in that:

[0006] A wet granulation device comprises a granulator container and a granulator pot cover, wherein a stirring assembly is arranged at the bottom of the granulator container, a cutting assembly is arranged radially on one side of the granulator container, and a two-flow atomizer is arranged on the granulator pot cover, wherein the two-flow atomizer has a liquid nozzle and a gas nozzle, and the two-flow atomizer is respectively connected to a liquid circuit assembly and a gas circuit assembly, wherein the liquid circuit assembly is communicated with the liquid nozzle, and the gas circuit assembly is communicated with the gas nozzle, and the gas nozzle is annular and surrounds the liquid nozzle, wherein the liquid circuit assembly is used for inputting an adhesive, and the gas circuit assembly is used for inputting a gas for atomizing the adhesive.

[0007] Preferably, the two-flow atomizer is located in the material incoming direction of the cutting assembly.

[0008] Preferably, taking the center of the stirring assembly as the origin, the two-flow atomizer is located in the region of 90°-180° in the direction of the material coming from the cutting assembly.

[0009] Preferably, the two-flow atomizer also has a liquid barrel, a gas barrel, a distributor, and a valve body. The liquid barrel is located in the gas barrel so that an air flow channel is formed between the liquid barrel and the gas barrel. The valve body has a liquid flow channel and an air flow channel. The liquid flow channel is respectively connected to the outlet of the liquid barrel and the liquid nozzle, and the air flow channel is respectively connected to the outlet of the gas barrel and the gas nozzle. The distributor includes a straight barrel portion and a side barrel portion. One end of the straight barrel portion is open and the other end is sealed. The open end of the straight barrel portion is sleeved and connected to the inlet of the gas barrel, and the sealed end of the straight barrel portion is sealed and fixed to the liquid barrel. The inlet of the liquid barrel is connected to the liquid circuit assembly, one end of the side barrel portion is connected to the straight barrel portion, and the other end is connected to the gas circuit assembly.

[0010] Preferably, the valve body is respectively provided with threaded connection ports of a liquid barrel, a gas barrel, a liquid nozzle, and a gas nozzle, the threaded connection ports of the liquid barrel and the liquid nozzle are communicated with the liquid flow channel of the valve body, the threaded connection ports of the gas barrel and the gas nozzle are communicated with the gas flow channel of the valve body, and the liquid barrel, the gas barrel, the liquid nozzle, the gas nozzle and the valve body are respectively sealed by sealing rings;

[0011] The open end of the straight barrel part is threadedly matched with the gas barrel and sealed by a sealing ring. The sealed end of the straight barrel part is threadedly matched with the liquid barrel / clearance matched. The liquid barrel is provided with a locking nut for locking the straight barrel part and the liquid barrel. The locking nut and the sealed end of the straight barrel part are sealed by a sealing ring.

[0012] Preferably, the two-flow atomizer is installed on the granulator pot cover through a locking mechanism, and the locking mechanism includes a locking nut, a locking sleeve, and a locking base. The locking nut, locking sleeve, and locking base are respectively mounted on the gas gun barrel, and the locking sleeve is made of elastic material. The upper and lower ends of the locking sleeve are both conical. The upper end of the locking nut is in the shape of a tapered hole and cooperates with the locking sleeve. The inner side of the upper end of the locking base is in the shape of a tapered hole and cooperates with the lower end of the locking sleeve. The outer side of the upper end of the locking base cooperates with the lower end thread of the locking nut, and the lower end of the locking base is connected to the connector provided on the granulator pot cover.

[0013] Preferably, the gas gun barrel has scale lines for observing and recording the upper and lower positions of the two-flow atomizer;

[0014] The material of the locking sleeve is polytetrafluoroethylene, and a food-grade silicone rubber sealing ring is arranged between the locking base and the gas gun barrel.

[0015] Preferably, a liquid turbulence ring is provided in the liquid nozzle for primary atomization of the adhesive, and a gas turbulence ring is provided in the gas nozzle for secondary atomization of the adhesive.

[0016] Preferably, the axis lines of the gas nozzle and the liquid nozzle of the two-flow atomizer form an angle of 22.5° with the axis lines of the gas barrel and the liquid barrel.

[0017] Preferably, the gas circuit assembly includes an air pipe and a gas quick-release connector, and the gas quick-release connector is connected to the side barrel; the liquid circuit assembly includes a liquid pipe and a locking liquid pipe connector, and the locking liquid pipe connector is connected to the inlet of the liquid gun barrel through a quick-release clamp.

[0018] Due to the adoption of the above technical solution, the present invention has the following beneficial effects:

[0019] The invention solves the technical problem that when the wet granulation device in the prior art atomizes the adhesive, the adhesive is easily accumulated in one place, the atomization area is small, the atomization effect is poor, the drug granulation is uneven, the drug particle content is unstable, and the drug particles are easy to be delaminated and cracked, which affects the quality and effect of the drug particles.

[0020] During wet granulation, the adhesive can be sprayed along the tangential direction of the material. When the wet granulation device atomizes the adhesive, the spray route of the adhesive does not affect the movement trajectory of the material, and the adhesive is not easy to accumulate in one place, which increases the atomization area and improves the atomization effect. The probability of the material combining with the adhesive during the movement cycle is equivalent, which ensures the uniform granulation of the drug, and the drug particles are not easy to be delaminated and cracked, which improves the quality of the drug particles. The locking mechanism and the barrel scale enable the granulation device to repeatedly and stably achieve a good granulation process. The wet granulation device greatly improves the process stability and reproducibility of wet granulation, and at the same time greatly optimizes the granulation effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the structure of the present invention;

[0022] Figure 2 It is a schematic diagram of the structure of a two-flow atomizer;

[0023] Figure 3 is a structural schematic diagram of the locking mechanism;

[0024] Figure 4 It is a schematic diagram of gas circuit components and liquid circuit components;

[0025] Figure 5 It is a schematic diagram of the plane layout structure of the present invention;

[0026] Figure 6 It is a cross-sectional schematic diagram of the connection of the valve body, the gas nozzle and the liquid nozzle;

[0027] Figure 7 This is a diagram of the dispersion effect formed by the two-flow atomizer under the pressure of the adhesive liquid;

[0028] Figure 8 This is a diagram of the atomization effect formed by a two-flow atomizer under the dual action of gas and liquid.

[0029] Reference numerals

[0030] In the accompanying drawings, 1-locking mechanism, 2-two-flow atomizer, 3-granulator pot cover, 4-gas nozzle, 5-liquid nozzle, 6-gas circuit assembly, 7-liquid circuit assembly, 8-gas nozzle, 9-liquid nozzle, 11-valve body, 12-liquid circuit sealing ring, 13-liquid barrel, 14-locking nut, 15-gas barrel, 16-trachea sealing ring, 17-distributor, 18-locking base, 19-locking nut, 20-scale line, 21-polytetrafluoroethylene locking sleeve, 22-sealing ring, 23-polyurethane transparent air pipe, 24-gas quick-release connector, 25-liquid pipe, 26-locking stainless steel liquid pipe connector, 27-quick-release clamp, 28-cutting knife (cutting assembly), 29-two-flow atomizer installation area, 33-liquid spoiler ring, 34-gas spoiler ring. DETAILED DESCRIPTION

[0031] See also Figure 1-Figure 8 , is an embodiment of a wet granulation device provided by the present invention, the wet granulation device comprises a locking mechanism 1, an air circuit assembly 6, a liquid circuit assembly 7 and a two-flow atomizer 2; the locking mechanism 1 comprises a locking base 18, a locking nut 19 and a polytetrafluoroethylene locking sleeve 21; the air circuit assembly 6 comprises an air pipe 23 and a gas quick-release connector 24; the liquid circuit assembly 7 comprises a liquid pipe 25 and a locking stainless steel liquid pipe connector 26; the two-flow atomizer 2 comprises a distributor 17, a gas barrel 15, a liquid barrel 13, a valve body 11, a gas nozzle 8, and a liquid nozzle 9; the two-flow atomizer 2 is installed in a wet On the granulator pot cover 3, there is a scale line 20 on the gas barrel 15 of the two-flow atomizer 2, and the two-flow atomizer 2 can be moved up and down by the locking mechanism 1 on the pot cover 3. The outside of the two-flow atomizer 2 is the gas barrel 15, and the gas nozzle 8 has a gas spoiler ring 34. The inside of the two-flow atomizer 2 is the liquid barrel 13, and the liquid nozzle 9 has a liquid spoiler ring 33. The axis of the gas nozzle 8, the liquid nozzle 9, and the valve body 11 of the two-flow atomizer 2 is at an angle of 22.5° to the axis of the gas barrel 15 and the liquid barrel 13. During wet granulation, the adhesive can be sprayed along the tangential direction of the material. The gas nozzle is annular and surrounds the liquid nozzle. When an angle is formed, the liquid nozzle is surrounded by the gas nozzle. When the liquid flows out, it is dispersed by the gas, and the liquid will not adhere to the nozzle. Moreover, the flow field is not prone to turbulence after the liquid flows out of the liquid nozzle, thereby effectively preventing the liquid from adhering to the spray gun head (if adhesion occurs, it is easy to cause spray failure).

[0032] In this embodiment, the two-flow atomizer 2 is fixedly connected to the granulator pot cover 3; the two-flow atomizer 2 is connected to the locking mechanism 1, the two-flow atomizer 2 is located at a specific position on the wet granulator pot cover 3, and the position is located in the area 90° to 180° in front of the cutting knife. A food-grade silicone rubber sealing ring 22 is provided between the two-flow atomizer 2 and the locking mechanism 1. There are scale lines 20 on the gas barrel 15 of the two-flow atomizer 2. The axis of the valve body 11, gas nozzle 8, and liquid nozzle 9 of the two-flow atomizer 2 form an angle of 22.5 with the axis of the outer tube of the atomizer; a liquid spoiler ring 33 is provided in the liquid nozzle 9 of the two-flow atomizer 2. After the liquid passes through the spoiler ring, the liquid is subjected to the pressure of the liquid itself. The dispersion effect is formed under the condition that the first atomization of the liquid is dispersed into large particles. The greater the liquid pressure, the smaller the dispersed particles. The base material of the wet granulator is dry fine powder in the early stage of granulation, which is easy to cause dust. The liquid nozzle 9 of the two-flow atomizer 2 is used to directly spray the liquid, which is helpful to humidify the material and will not cause dust of the fine powder; the outside of the liquid nozzle 9 is a gas nozzle 8, and the inside of the gas nozzle 8 is provided with a gas turbulence ring 34. The gas can form a secondary atomization of the liquid through the nozzle, so that the above-mentioned dispersed large particles become smaller, which is more conducive to the smooth progress of granulation. At this stage, the material has changed from dry fine powder to moist soft material. Even if gas is blown into the inside of the pot, it will not cause dust, so that the granulation process can be completed well.

[0033] During wet granulation, the adhesive can be sprayed along the tangential direction of the material. When the wet granulation device atomizes the adhesive, the spray route of the adhesive does not affect the movement trajectory of the material, and the adhesive is not easy to accumulate in one place, which increases the atomization area and improves the atomization effect. The probability of the material combining with the adhesive during the movement cycle is equivalent, which ensures uniform drug granulation, and the drug particles are not easy to be delaminated and cracked, which improves the quality of the drug particles. The locking mechanism 1 and the barrel scale enable the granulation device to repeatedly and stably achieve a good granulation process. The wet granulation device greatly improves the process stability and reproducibility of wet granulation, and at the same time greatly optimizes the granulation effect.

[0034] The gas gun barrel 15 and the liquid gun barrel 13 both vertically penetrate the granulator pot cover, the gas nozzle 8 and the liquid nozzle 9 are both connected to the valve body 11 by threads, the gas gun barrel 15, the liquid gun barrel 13 and the distributor 17 are connected to the valve body 11 by threads and nuts, the gas gun barrel 15 is sleeved on the outside of the liquid gun barrel 13, and the axial center lines of the gas gun barrel 15 and the liquid gun barrel 13 coincide with each other, after the gas nozzle 8, the liquid nozzle 9 are connected to the valve body 11, the outlet of the liquid nozzle 9 is higher than the outlet of the gas nozzle 8, the upper end of the locking base is provided with a tapered hole, the tapered hole cooperates with the polytetrafluoroethylene tensioning sleeve with a through hole in the middle of the two cone sections, one end of the locking nut 19 is provided with a tapered hole, the tapered hole cooperates with the other cone section of the polytetrafluoroethylene tensioning sleeve, so as to achieve the purpose of locking the gun rod.

[0035] In this embodiment, the locking mechanism 1 includes a locking base, a locking nut 19, and a locking sleeve. The locking base and the locking nut 19 are both made of 316L material, and the locking sleeve is made of polytetrafluoroethylene (PTFE). The gas circuit assembly 6 uses a stainless steel quick-release connector and a polyurethane transparent air pipe 23. The liquid circuit assembly 7 uses a stainless steel locking connector, a silicone rubber or polyurethane liquid pipe. The two-flow atomizer 2 includes a distributor 17, a gas barrel 15, a liquid barrel 13, a valve body 11, a gas nozzle 8, and a liquid nozzle 9. Except for the sealing ring 22, which is made of food-grade silicone rubber, the rest are made of 316L stainless steel. The two-flow atomizer 2 is connected to the locking mechanism 1, and there is a scale line 20 on the outer tube of the two-flow atomizing gas, which can observe and record the installation position of the spray gun. When the locking base and the locking nut move toward each other, the locking sleeve is deformed and locked, and when it moves in the opposite direction, it is loosened. The lower end of the locking base is connected to the connector on the pot cover of the granulator through a locking liquid pipe joint and a quick-release clamp.

[0036] In the implementation of the present embodiment, when the locking mechanism 1 is released, the two-stream atomizer 2 can move up and down, and can also rotate 360° along the axis of the gas barrel 15, so that the spray area of ​​the entire atomizer can be moved over a large range. There are scale lines 20 on the gas barrel 15 of the two-stream atomizer 2, which can record the up and down positions of the two-stream atomizer 2 and repeat the positioning multiple times to ensure stability.

[0037] The liquid nozzle 9 has a liquid spoiler ring 33 inside, and the gas nozzle has a gas spoiler ring 34 inside. After the liquid passes through the liquid spoiler ring 33, it forms a dispersion effect under the pressure of the liquid itself, achieving the first atomization of the liquid and dispersing it into large particles. The greater the liquid pressure, the smaller the dispersed particles. The base material of the wet granulator is dry fine powder in the early stage of granulation, which is easy to raise dust. The liquid nozzle 9 of the two-flow atomizer 2 is used to directly spray the liquid, which helps to humidify the material and will not cause dust of the fine powder; the outside of the two-flow liquid nozzle 9 is a gas nozzle 8, and the gas spoiler ring 34 is arranged inside the gas nozzle 8. The gas can form a secondary atomization of the liquid through the spray, so that the above-mentioned dispersed large particles become smaller, which is more conducive to the smooth progress of granulation. At this stage, the material has changed from dry fine powder to wet soft material. Even if gas is blown into the inside of the pot, it will not cause dust, so that the granulation process can be completed well.

[0038] In addition, the two-flow atomizer 2 and the granulator pot cover 3 have specific installation positions. When looking down from the top, the material in the wet granulator rotates counterclockwise, and the area 90° to 180° in front of the arc position of the cutting knife 28 is the installation area of ​​the two-flow atomizer 2. By installing the two-flow atomizer 2 in this area, the combination area of ​​the liquid and the material can be located in front of the cutting knife 28. When the liquid and the material are combined, the cutting knife 28 cuts them at a high speed, which is conducive to uniform granulation.

[0039] The kinetic energy of the two-flow atomizer's airless atomization (only adhesive is introduced) comes from the peristaltic pump driven by a servo motor. The speed of the servo motor is controlled by a program. The servo motor works at a high speed to form a high flow rate of the adhesive liquid. The high-flow adhesive hits the spoiler ring in the liquid nozzle to achieve atomization. The program can set the running time and running speed; gas atomization (adhesive and atomizing gas are introduced at the same time) is based on airless atomization, and then atomizing gas is introduced. The opening and closing of the atomizing gas is controlled by the opening and closing of the solenoid valve, and the pressure of the atomizing gas is controlled by the pressure regulating valve. The solenoid valve and the pressure regulating valve are controlled by the program respectively, and the kinetic energy of the additional gas can make the liquid particles atomized smaller.

[0040] Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made in form and details without departing from the scope defined by the claims of the present invention.

Claims

1. A wet granulation device, comprising a granulator container and a granulator pot cover, wherein a stirring assembly is arranged at the bottom of the granulator container, and a cutting assembly is arranged radially on one side of the granulator container, characterized in that: The granulator pot cover is provided with a two-flow atomizer, the two-flow atomizer has a liquid nozzle and a gas nozzle, the two-flow atomizer is connected to a liquid circuit assembly and a gas circuit assembly respectively, the liquid circuit assembly is connected to the liquid nozzle, the gas circuit assembly is connected to the gas nozzle, the gas nozzle is annular and surrounds the liquid nozzle, the liquid circuit assembly is used to input an adhesive, and the gas circuit assembly is used to input a gas for atomizing the adhesive; The two-flow atomizer also comprises a liquid gun barrel, a gas gun barrel, a distributor, and a valve body. The liquid gun barrel is located in the gas gun barrel so that an air flow channel is formed between the liquid gun barrel and the gas gun barrel. The valve body comprises a liquid flow channel and an air flow channel. The liquid flow channel is respectively connected with the outlet of the liquid gun barrel and the liquid nozzle, and the air flow channel is respectively connected with the outlet of the gas gun barrel and the gas nozzle. The distributor comprises a straight barrel portion and a side barrel portion. One end of the straight barrel portion is open and the other end is sealed. The open end of the straight barrel portion is sleeved and connected with the inlet of the gas gun barrel. The sealed end of the straight barrel portion is sealed and fixed with the liquid gun barrel. The inlet of the liquid gun barrel is connected with the liquid circuit assembly. One end of the side barrel portion is connected with the straight barrel portion, and the other end is connected with the gas circuit assembly. The valve body is respectively provided with threaded connection ports of a liquid gun barrel, a gas gun barrel, a liquid nozzle, and a gas nozzle, the threaded connection ports of the liquid gun barrel and the liquid nozzle are connected to the liquid flow channel of the valve body, and the threaded connection ports of the gas gun barrel and the gas nozzle are connected to the gas flow channel of the valve body, and the liquid gun barrel, the gas gun barrel, the liquid nozzle, the gas nozzle and the valve body are respectively sealed by sealing rings; The open end of the straight barrel part is threadedly matched with the gas barrel and sealed by a sealing ring, the sealed end of the straight barrel part is threadedly matched with the liquid barrel / clearance matched, the liquid barrel is provided with a locking nut for locking the straight barrel part and the liquid barrel, and the locking nut and the sealed end of the straight barrel part are sealed by a sealing ring; The two-flow atomizer is installed on the granulator pot cover through a locking mechanism. The locking mechanism includes a locking nut, a locking sleeve, and a locking base. The locking nut, locking sleeve, and locking base are respectively sleeved on the gas gun barrel. The locking sleeve is made of elastic material. The upper end and the lower end of the locking sleeve are both conical. The upper end of the locking nut is in a tapered hole shape and cooperates with the locking sleeve. The inner side of the upper end of the locking base is in a tapered hole shape and cooperates with the lower end of the locking sleeve. The outer side of the upper end of the locking base is threadedly matched with the lower end of the locking nut. The lower end of the locking base is connected to a connector arranged on the granulator pot cover.

2. A wet granulation device according to claim 1, characterized in that: The two-flow atomizer is located in the material incoming direction of the cutting assembly.

3. A wet granulation device according to claim 2, characterized in that: Taking the center of the stirring assembly as the origin, the two-flow atomizer is located in the area of ​​90°-180° in the direction of the material coming from the cutting assembly.

4. A wet granulation device according to claim 1, characterized in that: The gas gun barrel is provided with scale lines for observing and recording the upper and lower positions of the two-flow atomizer; The material of the locking sleeve is polytetrafluoroethylene, and a food-grade silicone rubber sealing ring is arranged between the locking base and the gas gun barrel.

5. A wet granulation device according to claim 1, characterized in that: A liquid turbulence ring is arranged in the liquid nozzle for atomizing the adhesive once, and a gas turbulence ring is arranged in the gas nozzle for atomizing the adhesive twice.

6. A wet granulation device according to claim 1, characterized in that: The axis lines of the gas nozzle and the liquid nozzle of the two-flow atomizer form an angle of 22.5° with the axis lines of the gas gun barrel and the liquid gun barrel.

7. A wet granulation device according to claim 1, characterized in that: The gas circuit assembly includes an air pipe and a gas quick-release joint, and the gas quick-release joint is connected to the side tube; the liquid circuit assembly includes a liquid pipe and a locking liquid pipe joint, and the locking liquid pipe joint is connected to the inlet of the liquid gun barrel through a quick-release clamp.

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