Water circulation thawing system and cryoprecipitate preparation apparatus

Abstract

The present application provides a water circulation thawing system and a cold precipitation preparation instrument, wherein a large water tank is connected to a first external water supply unit, a first external drainage unit, and a temperature regulator, the temperature regulator is connected to the large water tank to form a water circulation, a first water pump is arranged between pipelines to provide power for the water circulation, a plurality of water baths are accommodated in the large water tank, each water bath is used to accommodate a blood bag, and the water bath is connected to a second external water supply unit and a second external drainage unit; a control valve assembly is arranged between pipelines to control the opening and closing of the waterway between the first external water supply unit and the large water tank, the opening and closing of the waterway between the large water tank and the first external drainage unit, the opening and closing of the waterway between the second external water supply unit and the water bath, and the opening and closing of the waterway between the water bath and the second external drainage unit. The large water tank accommodates a plurality of water baths to improve the preparation efficiency, and the water baths are independent of each other, so as to avoid the cross contamination of the blood bag due to plasma leakage, and improve the safety of cold precipitation.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a water circulation thawing system and a cryoprecipitation preparation apparatus. Background Art

[0002] Preparation of cryoprecipitate is one of the routine projects of blood stations. In the process of preparing cryoprecipitate, multiple blood bags containing fresh frozen plasma are usually melted at the same time to improve the preparation efficiency of cryoprecipitate. However, studies have found that in the process of preparing multiple blood bags containing fresh frozen plasma at the same time, plasma leakage may occur during melting due to damage to blood bags, operator errors, and other reasons, which may lead to cross-contamination between blood bags and seriously affect the safety of cryoprecipitate. Summary of the invention

[0003] The embodiments of the present application propose a water circulation thawing system and a cryoprecipitate preparation apparatus to solve the technical problem of the safety of cryoprecipitate.

[0004] The embodiments of the present application achieve the above-mentioned objectives through the following technical solutions.

[0005] In a first aspect, an embodiment of the present application provides a water circulation thawing system, which includes a large water tank, a first water pump, a temperature regulator, multiple pipes, multiple water baths, and a control valve assembly. The first water inlet of the large water tank is used to communicate with a first external water supply unit through a pipe, the first water outlet of the large water tank is used to communicate with a first external drainage unit through a pipe, the second water outlet of the large water tank is connected to the water inlet of the temperature regulator through a pipe, the water outlet of the temperature regulator is connected to the second water inlet of the large water tank through a pipe to form a water circulation, and the first water pump is arranged between the pipes to provide power for the water circulation; the multiple water The bathing boxes are all accommodated in the large water tank, each water bath box is used to accommodate a blood bag, the water inlet of the water bath box is connected with the second external water supply unit through a pipe, and the water outlet of the water bath box is connected with the second external drainage unit through a pipe; the control valve assembly is arranged between the pipes, and is used to control the open and close of the water path between the first external water supply unit and the first water inlet of the large water tank, and is also used to control the open and close of the water path between the first water outlet of the large water tank and the first external drainage unit, and is also used to control the open and close of the water path between the second external water supply unit and the water inlet of the water bath box, and is also used to control the open and close of the water path between the water outlet of the water bath box and the second external drainage unit.

[0006] In some embodiments, the water circulation thawing system also includes multiple second water pumps corresponding to the multiple water baths. The water outlet of the water bath is also connected to the water inlet of the water bath through a pipeline to form a water circulation. The second water pump is arranged between the water outlet of the water bath and the water inlet of the water bath through a pipeline to provide power for the water circulation; the control valve assembly is also used to control the opening and closing of the water path between the water outlet of the water bath and the water inlet of the water bath.

[0007] In some embodiments, the water inlet of the second water pump is connected to the second external water supply unit through a pipe, the water outlet of the second water pump is connected to the water inlet of the water bath through a pipe, and the water outlet of the water bath is also connected to the water inlet of the second water pump through a pipe to form a water circulation; the control valve assembly is also used to control the connection and disconnection of the water path between the water outlet of the water bath and the water inlet of the second water pump.

[0008] In some embodiments, the temperature regulator includes a refrigerant system and a water cooling system; the refrigerant system includes a compressor, a condenser, a throttling device, and a refrigerant channel in an evaporator which are connected by pipes to form a refrigerant circulation loop, the output end of the compressor is connected to the input end of the condenser, the output end of the condenser is connected to the input end of the throttling device, the output end of the throttling device is connected to the input end of the refrigerant channel, and the output end of the refrigerant channel is connected to the input end of the compressor; the water cooling system includes a large water tank, a water cooling channel in the evaporator, and a heater which are connected by pipes to form a water cooling circulation loop; the first water inlet of the large water tank is connected to the first external water supply unit, the first water outlet of the large water tank is connected to the first external drainage unit, the second water outlet of the large water tank is connected to the water inlet of the water cooling channel, the water outlet of the water cooling channel is connected to the water inlet of the heater, and the water outlet of the heater is connected to the second water inlet of the large water tank.

[0009] In some embodiments, the first water pump is installed between the second water outlet of the large water tank and the water inlet of the water cooling channel or between the water outlet of the water cooling channel in the evaporator and the second water inlet of the large water tank.

[0010] In some embodiments, the control valve assembly includes a first solenoid valve, a second solenoid valve, a third solenoid valve, a fourth solenoid valve and a fifth solenoid valve, wherein the first end of the first solenoid valve is connected to the first external water supply unit through a pipe, and the second end of the first solenoid valve is connected to the first water inlet of the large water tank through a pipe; the first end of the second solenoid valve is connected to the first external drainage unit through a pipe, and the second end of the second solenoid valve is connected to the first water outlet of the large water tank through a pipe; the first end of the third solenoid valve is connected to the second external water inlet unit through a pipe, and the second end of the third solenoid valve is connected to the water inlet of the water bath through a pipe; the first end of the fourth solenoid valve is connected to the second external drainage unit through a pipe, and the second end of the fourth solenoid valve is connected to the first end of the fifth solenoid valve through a pipe, and the second end of the fifth solenoid valve is connected to the water outlet of the water bath through a pipe; the second end of the third solenoid valve is also connected to the second end of the fourth solenoid valve.

[0011] In some embodiments, the water circulation thawing system also includes multiple water storage tanks and multiple second water pumps corresponding to the multiple water baths respectively. The water storage tanks are connected to the water inlet of the second water pump and the water outlet of the water bath through pipes, and the water outlet of the second water pump is connected to the water inlet of the water bath through pipes. The water storage tank is also connected to the second external water supply unit and the second external drainage unit through pipes. The control valve assembly is used to control the connection and disconnection of the water path between the second external water supply unit and the water storage tank, and is also used to control the connection and disconnection of the water path between the water storage tank and the second external drainage unit, and is also used to control the connection and disconnection of the water path between the water storage tank and the water inlet of the second water pump, and is also used to control the connection and disconnection of the water path between the water outlet of the water bath and the water storage tank.

[0012] In some embodiments, the water circulation thawing system also includes a water tank, the drain outlet of the water tank is connected to the water inlet of the second water pump through a pipe, the water inlet of the water tank is connected to the second external water supply unit through a pipe, and the water outlet of the water tank is connected to the second external drainage unit through a pipe; the control valve assembly is used to control the connection and disconnection of the water path between the second external water supply unit and the water tank, and is also used to control the connection and disconnection of the water path between the water tank and the second external drainage unit, and is also used to control the connection and disconnection of the water path between the water tank and the water inlet of the second water pump, and is also used to control the connection and disconnection of the water path between the water outlet of the water bath tank and the water tank.

[0013] In some embodiments, the control valve assembly includes a first solenoid valve, a second solenoid valve, a third solenoid valve, a fourth solenoid valve, a fifth solenoid valve and a sixth solenoid valve, wherein a first end of the first solenoid valve is connected to a first external water supply unit through a pipeline, and a second end of the first solenoid valve is connected to a first water inlet of a large water tank through a pipeline; a first end of the second solenoid valve is connected to a first external drainage unit through a pipeline, and a second end of the second solenoid valve is connected to a first water outlet of the large water tank through a pipeline; a first end of the third solenoid valve is connected to a second external water inlet unit through a pipeline, and a second end of the third solenoid valve is connected to a water inlet of a water storage tank through a pipeline; a first end of the fourth solenoid valve is connected to a second external drainage unit through a pipeline, and a second end of the fourth solenoid valve is connected to a water outlet of a water storage tank through a pipeline, and the water outlet of the water storage tank is connected to a first end of a sixth solenoid valve through a pipeline, a second end of the sixth solenoid valve is connected to a water inlet of a second water pump through a pipeline, a second end of the sixth solenoid valve is also connected to a first end of the fifth solenoid valve through a pipeline, and a second end of the fifth solenoid valve is connected to a water outlet of a water bath through a pipeline.

[0014] In some embodiments, the water circulation thawing system further includes a temperature sensor, and the temperature sensor is disposed in the large water tank and / or the water bath.

[0015] In some embodiments, the water circulation thawing system further includes a liquid level sensor, and the liquid level sensor is disposed in the large water tank and / or the water bath tank.

[0016] In some embodiments, the water circulation thawing system also includes a first filter and a second filter, the first end of the first filter is connected to the first external water supply unit through a pipe, and the second end of the first filter is connected to the control valve assembly through a pipe; the first end of the second filter is connected to the second external water supply unit through a pipe, and the second end of the second filter is connected to the control valve assembly through a pipe.

[0017] In a second aspect, an embodiment of the present application provides a cold precipitate preparation apparatus, which includes a water circulation thawing system of any of the above embodiments.

[0018] In some embodiments, the cold precipitation preparation instrument also includes multiple placement units and multiple exhaust units, wherein the placement units are used to place empty bags of the external double bags, the placement units correspond one-to-one to the water baths and form a height difference, the height of the water bath from the ground is higher than the height of the placement units from the ground, and the exhaust units are arranged between the water bath and the placement units, and are used to clamp the ducts of the external double bags for exhaust.

[0019] In the water circulation thawing system and cold precipitate preparation instrument provided in the embodiments of the present application, a blood bag is placed in a water bath for plasma melting, the water bath is placed in a large water tank, the large water tank, the first water pump, and the temperature regulator can form a water circuit, the temperature regulator adjusts the temperature of the water, and the temperature-adjusted water is re-transported to the large water tank via the first water pump to meet the temperature requirements in the cold precipitate preparation process; multiple water baths are placed in the large water tank to perform melting work at the same time, so as to improve the efficiency of the water circulation thawing system in preparing cold precipitates; the multiple water baths are independent of each other, and each water bath can accommodate at most one blood bag. Compared with other methods of melting multiple blood bags at the same time in the same water bath, this avoids plasma leakage due to damage to one of the blood bags, and further avoids cross-contamination between blood bags, thereby improving the safety of cold precipitates. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For those skilled in the art, other drawings can be obtained based on these drawings without creative work.

[0021] Figure 1 A schematic diagram of the modules of the water circulation thawing system provided in an embodiment of the present application.

[0022] Figure 2 A schematic diagram of a portion of the structure of the water circulation thawing system provided in an embodiment of the present application.

[0023] Figure 3A schematic diagram of a module of a water circulation thawing system provided in another embodiment of the present application.

[0024] Figure 4 A schematic diagram of a module of a water circulation thawing system provided in another embodiment of the present application.

[0025] Figure 5 A schematic diagram of a portion of the structure of a water circulation thawing system provided in another embodiment of the present application.

[0026] Figure 6 A schematic diagram of a module of a water circulation thawing system provided in another embodiment of the present application.

[0027] Figure 7 A schematic structural diagram of a water circulation thawing system provided in another embodiment of the present application.

[0028] Figure 8 It is a structural schematic diagram of the cold precipitation preparation instrument provided in the embodiment of the present application. DETAILED DESCRIPTION

[0029] In order to enable those skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present application. It should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the term "connected" should be understood in a broad sense, which can be fixedly connected between two objects, or detachably connected, directly connected, or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0030] Cryoprecipitate is a process that uses a specific method to melt about 150mL or 200mL of fresh frozen plasma within the storage period at 1-6℃, separating most of the plasma and the remaining 40-50mL of insoluble substances. The main components of cryoprecipitate are factor VIII and fibrinogen. Cryoprecipitate is mainly used to treat patients with hemophilia, postoperative bleeding, severe trauma, disseminated intravascular coagulation, and fibrinogen and coagulation factor deficiency.

[0031] There are two main methods for preparing cold precipitate: one is centrifugation, and the other is water bath siphon method. The centrifugation method is to place the blood bag containing fresh frozen plasma in an environment of 4℃±2℃ to melt, and take out the crushed ice cubes in time when there are still a few pieces of ice cubes in the plasma, and put it in a centrifuge for centrifugation at 4℃±2℃, and separate the upper layer of plasma into a connected empty bag. The remaining 40-50mL of the lower layer is the cold precipitate. The water bath siphon method is to place the blood bag containing fresh frozen plasma in an environment of 4℃. When the frozen plasma melts, the siphon effect is used to make the melted plasma flow out of the blood bag, and the remaining 40-50mL component is the cold precipitate.

[0032] In the process of preparing cryoprecipitate by the above two methods, multiple blood bags containing fresh frozen plasma are usually thawed at the same time to improve the preparation efficiency of cryoprecipitate. However, studies have found that in the process of preparing multiple blood bags containing fresh frozen plasma at the same time, plasma leakage may occur during thawing due to damage to the blood bags, operator errors, and other reasons, thereby causing cross contamination between the blood bags, seriously affecting the safety and effectiveness of cryoprecipitate and plasma.

[0033] Based on this, see Figure 1 The embodiment of the present application provides a water circulation thawing system 100, which includes a large water tank 101, a first water pump 103, a temperature regulator 26, a plurality of pipes 20, a plurality of water baths 10 and a control valve assembly 30. The first water inlet of the large water tank 101 is used to be connected to a first external water supply unit (not shown) through the pipe 20, the first water outlet of the large water tank 101 is used to be connected to a first external drainage unit (not shown) through the pipe 20, the second water outlet of the large water tank 101 is connected to the water inlet of the temperature regulator 26 through the pipe 20, the water outlet of the temperature regulator 26 is connected to the second water inlet of the large water tank 101 through the pipe 20 to form a water circulation, and the first water pump 103 is arranged between the pipes 20 to form a water circulation. Provide power for water circulation; multiple water baths 10 are accommodated in the large water tank 101, each water bath 10 is used to accommodate a blood bag 60, the water inlet of the water bath 10 is connected to the second external water supply unit through the pipe 20, and the water outlet of the water bath 10 is connected to the second external drainage unit through the pipe 20; the control valve assembly 30 is arranged between the pipes 20, for controlling the on-off of the water path from the first external water supply unit to the first water inlet of the large water tank 101, and also for controlling the on-off of the water path from the first water outlet of the large water tank 101 to the first external drainage unit, and also for controlling the on-off of the water path from the second external water supply unit to the water inlet of the water bath 10, and also for controlling the on-off of the water path from the water outlet of the water bath 10 to the second external drainage unit.

[0034] The water bath 10 is preferably made of a metal material with high thermal conductivity. The capacity of the large water tank 101 is greater than the volume of the water bath 10 and is used to accommodate the water bath 10, so that the water in the water bath 10 and the water in the large water tank 101 can exchange heat in real time to achieve a constant temperature. The first external water supply unit can be a tap water source, and the water inlet of the first water pump 103 is connected to the faucet of the tap water pipe through the pipe 20. The first external drainage unit can be an underground drainage channel, and the water outlet of the large water tank 101 is connected to the entrance of the underground drainage channel through the pipe 20.

[0035] The temperature regulator 26 is used to keep the water in the large water tank 101 within a stable temperature range. Since the plasma needs to be melted in an environment of 4°C±2°C, the temperature regulator 26 can be set to a corresponding temperature to change the temperature of the water passing through the temperature regulator 26.

[0036] The first water pump 103 is used to pump water in the large water tank 101 to the temperature regulator 26 during water circulation, and then transport the water back to the large water tank 101 after being temperature-controlled by the temperature regulator 26 .

[0037] The water bath 10 is placed in a large water tank 101 for heat preservation. Each water bath 10 only accommodates one blood bag 60. Each second external water supply unit transports water to the corresponding water bath 10 through a pipe 20. The water in the water bath 10 is kept at 4°C ± 2°C by heat conduction from the water in the large water tank 101 to match the melting temperature requirement of the plasma in the blood bag 60. The term "plurality" in this application means greater than or equal to two. For example, the number of water baths 10 can be two or three or four or five or more. Accordingly, the number of second external water supply units is consistent with the number of water baths 10. Figure 1 In the example shown, the number of water baths 10 is twelve; Figure 2 In the example shown, the number of water baths 10 is two.

[0038] Multiple independent water baths 10 means that the environmental conditions in any water bath 10 (such as water volume, temperature, water inlet and outlet control, water supply source and wastewater discharge, etc.) are not affected by other water baths 10, and the water in any water bath 10 will not enter other water baths 10, and the water in any water bath 10 will not enter the large water tank 101. Multiple water baths 10 can be arranged at intervals or closely offset to improve the space utilization of the large water tank 101, so that the large water tank 101 can accommodate more water baths 10, which can increase the amount of cold precipitation prepared by the water circulation thawing system 100 per unit time.

[0039] The second external water supply unit can be a tap water source, and the water inlet of the water bath 10 is connected to the faucet of the tap water pipe through the pipe 20. The second external water supply unit and the first external water supply unit can be the same water supply unit, and the same water supply unit provides water to the large water tank 101 and the water bath 10 respectively, and since each system has an independent solenoid valve, they do not affect each other. The second external drainage unit can be an underground drainage channel, and the water outlet of the water bath 10 is connected to the entrance of the underground drainage channel through the pipe 20. The second external drainage unit and the first external drainage unit can be the same drainage unit, and the large water tank 101 and the water bath 10 respectively discharge water into the same drainage unit.

[0040] During the use of the water circulation thawing system 100, for the large water tank 101, the control valve assembly 30 closes the water path between the water outlet of the large water tank 101 and the first external drainage unit, and the water path between the first external water supply unit and the water inlet of the large water tank 101 is connected. At this time, the water in the first external water supply unit enters the pipe 20 and flows into the large water tank 101; the water flows from the second water outlet of the large water tank 101 into the pipe 20 and into the water inlet of the temperature regulator 26, and the temperature regulator 26 can change the temperature of the water. The water with changed temperature can be sucked back into the large water tank 101 by the first water pump 103 and mixed with the water in the large water tank 101, thereby changing the overall temperature of the water in the large water tank 101, so that the temperature of the water in the large water tank 101 is maintained within an appropriate temperature range, thereby forming a water circulation effect of the large water tank 101. In other embodiments, water flows from the second water outlet of the large water tank 101 into the pipe 20 and into the inlet of the first water pump 103. The water is sucked by the first water pump 103 and flows into the water inlet of the temperature regulator 26. After the temperature of the water is changed by the temperature regulator 26, it flows back into the large water tank 101, thereby forming a water circulation effect of the large water tank 101. Figure 1 The direction indicated by the thick arrow is the direction of water flow.

[0041] In the case of the water bath 10, the control valve assembly 30 closes the water path between the water outlet of the water bath 10 and the second external drainage unit, and the water path between the second external water supply unit and the water inlet of the water bath 10 is connected. At this time, the water in the second external water supply unit enters the pipe 20 and flows into the water bath 10.

[0042] After the blood bags 60 in a single water bath 10 complete the preparation of cold precipitate, the control valve assembly 30 keeps the water path between the second external water supply unit and the water inlet of the water bath 10 closed, the water path between the water outlet of the water bath 10 and the second external drainage unit is connected, and the water in the water bath 10 is discharged to the second external drainage unit through the pipe 20. Since the blood bag 60 is not affected by the situation of the blood bags 60 in other water baths 10 during the thawing process, and does not affect the situation of the blood bags 60 in other water baths 10, even if one of the blood bags 60 has plasma leakage during the thawing process, the water in the water bath 10 with leakage will not flow directly into other water baths 10, nor will it flow into other water baths 10 through the large water tank 101, thereby ensuring the independence of each cold precipitate preparation process.

[0043] After completing the entire cold precipitation preparation work, for the large water tank 101, the control valve assembly 30 keeps the water path between the first external water supply unit and the water inlet of the large water tank 101 closed, and the water path between the water outlet of the large water tank 101 and the first external drainage unit is connected. At this time, the water in the large water tank 101 is discharged to the first external drainage unit through the pipe 20.

[0044] In the water circulation thawing system 100 of the embodiment of the present application, the blood bag 60 is placed in the water bath 10 for plasma melting, the water bath 10 is contained in the large water tank 101, the large water tank 101 forms a water circuit with the first water pump 103 through the pipeline 20, the temperature regulator 26 is connected to the pipeline 20 to adjust the temperature of the water flowing through the pipeline 20, and the temperature-adjusted water is re-transported to the large water tank 101 via the first water pump 103 to meet the temperature requirements during the preparation of the cold precipitate; in addition, the water circulation thawing system 100 improves the preparation efficiency of the cold precipitate by setting up multiple water baths 10; the multiple water baths 10 are independent of each other, so that the water baths 10 do not affect each other during the working process, thereby avoiding the cross-contamination of blood bags 60 in different water baths 10 due to plasma leakage, thereby improving the safety of the cold precipitate.

[0045] In some embodiments, see Figure 2 and Figure 3 The water circulation thawing system 100 also includes a plurality of second water pumps 24 corresponding to the plurality of water baths 10. The water outlet of the water bath 10 is also connected to the water inlet of the water bath 10 through the pipe 20 to form a water circulation. The second water pump 24 is arranged between the water outlet of the water bath 10 and the water inlet of the water bath 10 through the pipe 20 to provide power for the water circulation. The control valve assembly 30 is also used to control the on-off of the waterway between the water outlet of the water bath 10 and the water inlet of the water bath 10. The second water pump 24 can be installed at the water inlet or the water outlet of the water bath 10. Figure 2 and Figure 3The situation where the second water pump 24 is installed at the water inlet of the water bath 10 is shown, specifically: the water inlet of the second water pump 24 is connected to the second external water supply unit through the pipe 20, the water outlet of the second water pump 24 is connected to the water inlet of the water bath 10 through the pipe 20, and the water outlet of the water bath 10 is also connected to the water inlet of the second water pump 24 through the pipe 20 to form a water circulation; the control valve assembly 30 is also used to control the connection and disconnection of the water path between the water outlet of the water bath 10 and the water inlet of the second water pump.

[0046] When the second water pump 24 is installed at the water inlet of the water bath 10, even if the water pressure of the second external water supply unit is low, the water can be transported to the water bath 10 through the pipe 20 by turning on the second water pump 24. Since the second water pump 24 can transport water from a low place to a high place, even if the water bath 10 is set at a position higher than the ground than the second external water supply unit, it does not affect the second external water supply unit from transporting water to the water bath 10, which is conducive to the placement of the water bath 10 can be adaptively adjusted and arranged according to the actual space of the water circulation thawing system 100.

[0047] During the water intake process of the water bath 10, the water path between the water outlet of the water bath 10 and the second external drainage unit is closed, the water path between the water outlet of the water bath 10 and the water inlet of the second water pump 24 is closed, and the water path between the second external water supply unit and the water inlet of the second water pump 24 is connected. The second water pump 24 may not be turned on, but may be turned on when the water pressure is low. At this time, the water in the second external water supply unit enters the pipeline 20, and the water is sucked and transported to the water bath 10 by the second water pump 24.

[0048] When the amount of water in the water bath 10 accumulates to a suitable position, the user can close the water path between the second external water inlet unit and the water inlet of the second water pump 24 to stop the water inflow, and the water path between the water outlet of the second water pump 24 and the water inlet of the water bath 10 is connected, and the water path between the water outlet of the water bath 10 and the second external drainage unit remains closed, and the water path between the water outlet of the water bath 10 and the water inlet of the second water pump 24 is connected, so that the water outlet of the water bath 10 is connected to the water inlet of the second water pump 24 through the pipe 20 to form a closed loop. At this time, the water in the water bath 10 is discharged from the water outlet, flows into the pipe 20 and flows to the second water pump 24, and the water is sucked by the second water pump 24 and re-delivered to the water bath 10, and this is repeated to form a water circulation effect. Since the temperature of the blood bag 60 is below zero when it is just taken out of the cold storage, the temperature of the water around the frozen blood bag 60 is below 4°C. In this embodiment, a water circulation effect is formed in the water bath 10 to make the water in the water bath 10 flow, which helps to keep the temperature of the water around the frozen blood bag 60 at around 4°C as much as possible, thereby helping to improve the preparation efficiency of the cold precipitate.

[0049] After the blood bag 60 in the water bath 10 completes the preparation of cold precipitation, the water path between the second external water supply unit and the water inlet of the water pump 24 remains closed, and the water path between the water outlet of the water bath 10 and the second external drainage unit is connected. At this time, the water in the water bath 10 is discharged into the second external drainage unit through the pipe 20. Figure 3 The direction indicated by the thick arrow is the direction of water flow.

[0050] In some embodiments, see Figure 3 The control valve assembly 30 includes a first solenoid valve 107, a second solenoid valve 108, a third solenoid valve 31, a fourth solenoid valve 32 and a fifth solenoid valve 33. The first end of the first solenoid valve 107 is connected to the first external water supply unit through the pipeline 20, and the second end of the first solenoid valve 107 is connected to the first water inlet of the large water tank 101 through the pipeline 20. The first end of the second solenoid valve 108 is connected to the first external drainage unit through the pipeline 20, and the second end of the second solenoid valve 108 is connected to the first water outlet of the large water tank 101 through the pipeline 20. The first end of the third solenoid valve 31 is connected to the second external water inlet unit through the pipeline 20, and the second end of the third solenoid valve 31 is connected to the water inlet of the water bath 10 through the pipeline 20. The first end of the fourth solenoid valve 32 is connected to the second external drainage unit through the pipeline 20, the second end of the fourth solenoid valve 32 is connected to the first end of the fifth solenoid valve 33 through the pipeline 20, and the second end of the fifth solenoid valve 33 is connected to the water outlet of the water bath 10 through the pipeline 20. The second end of the third solenoid valve 31 is also connected to the second end of the fourth solenoid valve 32 through the pipeline 20.

[0051] The first solenoid valve 107 and the second solenoid valve 108 work in cooperation with each other. During the water intake process, the first solenoid valve 107 connects the water path, and the second solenoid valve 108 closes the water path; during the water circulation process, the first solenoid valve 107 and the second solenoid valve 108 both close the water path; during the drainage process, the first solenoid valve 107 closes the water path, and the second solenoid valve 108 connects the water path.

[0052] The third solenoid valve 31, the fourth solenoid valve 32 and the fifth solenoid valve 33 work in coordination with each other. During the water intake process, the third solenoid valve 31 connects the water path, and the fourth solenoid valve 32 and the fifth solenoid valve 33 both close the water path; during the water circulation process, the third solenoid valve 31 and the fourth solenoid valve 32 both close the water path, and the fifth solenoid valve 33 connects the water path; during the drainage process, the third solenoid valve 31 closes the water path, and the fourth solenoid valve 32 and the fifth solenoid valve 33 both connect the water path.

[0053] The first solenoid valve 107 , the second solenoid valve 108 , the third solenoid valve 31 , the fourth solenoid valve 32 and the fifth solenoid valve 33 are solenoid valves of the same type, for example, they may be direct-acting solenoid valves, step-by-step direct-acting solenoid valves, pilot-operated solenoid valves, etc.

[0054] In some embodiments, when the water bath 10 does not need to form a water circulation, please refer to Figure 4 The water circulation thawing system 100 also includes a plurality of water tanks 28 and a plurality of second water pumps 24, each water tank 28, each second water pump 24 and each water bath 10 correspond to each other. The water tank 28 is connected to the water inlet of the second water pump 24 through the pipeline 20, the water outlet of the second water pump 24 is connected to the water inlet of the water bath 10 through the pipeline 20, the water tank 28 is connected to the water outlet of the water bath 10 through the pipeline 20, and the water tank 28 is also connected to the second external water supply unit and the second external drainage unit through the pipeline 20. The control valve assembly 30 is used to control the on-off of the waterway between the second external water supply unit and the water tank 28, and is also used to control the on-off of the waterway between the water tank 28 and the second external drainage unit, and is also used to control the on-off of the waterway between the water tank 28 and the water inlet of the second water pump 24, and is also used to control the on-off of the waterway between the water outlet of the water bath 10 and the water tank 28.

[0055] Generally, after the preparation of the cold precipitate of a blood bag is completed, the water in the water bath 10 is usually drained to prepare the cold precipitate of the next blood bag. The water circulation thawing system 100 of the present embodiment collects the water discharged from the water bath 10 by arranging a water storage tank 28. On the one hand, the water used to prepare the cold precipitate last time can be reused to save water cost. On the other hand, since the parameters of the water used to prepare the cold precipitate last time (such as temperature, water volume, etc.) are closer to the conditions for preparing the cold precipitate relative to the parameters of the water flowing into the water bath 10 again from the water source, the time consumed by adjusting the parameters of the water for preparing the cold precipitate next time is saved, which is conducive to improving the preparation efficiency of the cold precipitate. In addition, before reusing the water used to prepare the cold precipitate last time, it is necessary to perform leakage pollution detection on the water used to prepare the cold precipitate last time to avoid contamination of the cold precipitate prepared next time.

[0056] Based on this, during the water intake process of the water tank 28, the waterway between the second external water supply unit and the water tank 28 is connected, the waterway between the water tank 28 and the second external drainage unit is closed, the waterway between the water tank 28 and the water inlet of the second water pump 24 is closed, and the waterway between the water outlet of the water bath 10 and the water tank 28 is closed. At this time, the water in the second external water supply unit enters the water tank 28. When the amount of water in the water tank 28 accumulates to a suitable position, the waterway between the second external water supply unit and the water tank 28 is closed. Then, the water intake procedure of the water bath 10 is carried out, the waterway between the water tank 28 and the water inlet of the second water pump 24 is connected, the waterway between the water outlet of the water bath 10 and the water tank 28 remains closed, and the second water pump 24 is turned on for suction. When the amount of water in the water bath 10 accumulates to a suitable position, the waterway between the water tank 28 and the water inlet of the second water pump 24 is closed. After the blood bag 60 in the water bath 10 completes the preparation of cold precipitation, the waterway between the second external water supply unit and the water tank 28 remains closed, the waterway between the water tank 28 and the second external drainage unit is closed, the waterway between the water tank 28 and the water inlet of the second water pump 24 is closed, and the waterway between the water outlet of the water bath 10 and the water tank 28 is connected. At this time, the water in the water bath 10 is discharged to the water tank 28 for storage for the next cold precipitation preparation. When the water in the water tank 28 has been used multiple times or the water is polluted, the waterway between the water tank 28 and the second external drainage unit is controlled to be connected to discharge the sewage.

[0057] In the case where water circulation is required in the water bath 10, please refer to Figure 5 and Figure 6 The water circulation thawing system 100 further includes a water tank 28, the drain port of the water tank 28 is connected to the water inlet of the second water pump 24 through a pipe 20, the water inlet of the water tank 28 is connected to the second external water supply unit through a pipe 20, and the water outlet of the water tank 28 is connected to the second external drainage unit through a pipe 20. The control valve assembly 30 is used to control the on-off of the water path between the second external water supply unit and the water tank 28, and is also used to control the on-off of the water path between the water tank 28 and the second external drainage unit, and is also used to control the on-off of the water path between the water tank 28 and the water inlet of the second water pump 24, and is also used to control the on-off of the water path between the water outlet of the water bath 10 and the water tank 28.

[0058] During the process of water inflow into the water tank 28, the waterway between the second external water supply unit and the water tank 28 is connected, the waterway between the water tank 28 and the second external drainage unit is closed, the waterway between the water tank 28 and the water inlet of the second water pump 24 remains closed, and the waterway between the water outlet of the water bath 10 and the water tank 28 is closed. At this time, the water in the second external water supply unit enters the pipeline 20 and flows into the water tank 28. When the amount of water in the water tank 28 accumulates to a suitable position, the waterway between the second external water supply unit and the water tank 28 is closed. During the process of water inflow into the water bath 10, the waterway between the water tank 28 and the water inlet of the second water pump 24 remains connected, the second water pump 24 is turned on, and the second water pump 24 transports the water in the water tank 28 to the water bath 10 through suction. When the amount of water in the water bath 10 accumulates to a suitable position, the waterway between the water tank 28 and the water inlet of the second water pump 24 is closed. During the water circulation process, the water path between the second external water supply unit and the water tank 28 is closed, the water path between the water tank 28 and the second external drainage unit is closed, the water path between the water tank 28 and the water inlet of the second water pump 24 is closed, the water path between the water outlet of the water bath 10 and the water tank 28 remains closed, the water path between the water outlet of the second water pump 24 and the water inlet of the water bath 10 is connected, and the water path between the water outlet of the water bath 10 and the water inlet of the second water pump 24 is connected, so that the water bath 10 is connected to the second water pump 24 through the pipeline 20 to form a closed loop to form a water circulation effect.

[0059] After the blood bag 60 in the water bath 10 completes the preparation of the cold precipitate, the water outlet of the water bath 10 is connected to the water storage tank 28 and the water path therebetween, and the water in the water bath 10 is discharged to the water storage tank 28 for storage for the next cold precipitate preparation. When the water in the water storage tank 28 is used multiple times or the water is polluted, the water path between the water storage tank 28 and the second external drainage unit is controlled to be connected to discharge the sewage. Figure 6 The direction indicated by the medium thick arrow is the direction of water flow.

[0060] In the above-mentioned embodiment where the water circulation thawing system 100 includes a water storage tank 28 and the water bath 10 needs to form a water circulation, please refer to Figure 5 and Figure 6 The control valve assembly 30 includes the first solenoid valve 107,

[0061] The second solenoid valve 108, the third solenoid valve 31, the fourth solenoid valve 32 and the fifth solenoid valve 33 also include a sixth solenoid valve 34. The first end of the first solenoid valve 107 is connected to the first external water supply unit through the pipeline 20, and the second end of the first solenoid valve 107 is connected to the first water inlet of the large water tank 101 through the pipeline 20; the first end of the second solenoid valve 108 is connected to the first external drainage unit through the pipeline 20, and the second end of the second solenoid valve 108 is connected to the first water outlet of the large water tank 101 through the pipeline 20; the first end of the third solenoid valve 31 is connected to the second external water inlet unit through the pipeline 20, and the second end of the third solenoid valve 31 is connected to the water inlet of the water storage tank 28 through the pipeline 20 The first end of the fourth solenoid valve 32 is connected to the second external drainage unit through the pipe 20, the second end of the fourth solenoid valve 32 is connected to the water outlet of the water tank 28 through the pipe 20, the drain outlet of the water tank 28 is connected to the first end of the sixth solenoid valve 34 through the pipe 20, the second end of the sixth solenoid valve 34 is connected to the water inlet of the second water pump 24 through the pipe 20, the second end of the sixth solenoid valve 34 is also connected to the first end of the fifth solenoid valve 33 through the pipe 20, and the second end of the fifth solenoid valve 33 is connected to the water outlet of the water bath 10 through the pipe 20.

[0062] The third solenoid valve 31, the fourth solenoid valve 32, the fifth solenoid valve 33 and the sixth solenoid valve 34 work in coordination with each other. During the process of water inflow to the water storage tank 28, the third solenoid valve 31 connects the water path, the fourth solenoid valve 32 closes the water path, the fifth solenoid valve 33 closes the water path, and the sixth solenoid valve 34 closes the water path. During the process of water inflow to the water bath 10, the third solenoid valve 31 closes the water path, the fourth solenoid valve 32 closes the water path, the fifth solenoid valve 33 closes the water path, and the sixth solenoid valve 34 connects the water path. During the water circulation process, the third solenoid valve 31 closes the water path, the fourth solenoid valve 32 closes the water path, the fifth solenoid valve 33 connects the water path, and the sixth solenoid valve 34 closes the water path. During the process of water discharge from the water bath 10 and water storage in the water storage tank 28, the third solenoid valve 31 closes the water path, the fourth solenoid valve 32 closes the water path, the fifth solenoid valve 33 connects the water path, and the sixth solenoid valve 34 connects the water path. After the water in the water tank 28 is used multiple times or is polluted, the connection of the waterway between the water tank 28 and the second external drainage unit is controlled to discharge the sewage. At this time, during the drainage process of the water tank 28, the third solenoid valve 31 closes the waterway, the fourth solenoid valve 32 connects the waterway, the fifth solenoid valve 33 closes the waterway, and the sixth solenoid valve 34 closes the waterway. The third solenoid valve 31, the fourth solenoid valve 32, the fifth solenoid valve 33 and the sixth solenoid valve 34 can all be solenoid valves of the same type, and the types of the solenoid valves refer to the above embodiments.

[0063] In some embodiments, see Figure 6 and Figure 7 The temperature regulator 26 includes a refrigerant system and a water cooling system. The refrigerant system includes a compressor 2622, a condenser 2623, a throttling device 2624, and a refrigerant channel in an evaporator 2621. The compressor 2622, the condenser 2623, the throttling device 2624, and the refrigerant channel in the evaporator 2621 are connected through a pipeline 2620 to form a refrigerant circulation loop. The output end of the compressor 2622 is connected to the input end of the condenser 2623, the output end of the condenser 2623 is connected to the input end of the throttling device 2624, the output end of the throttling device 2624 is connected to the input end of the refrigerant channel in the evaporator 2621, and the output end of the refrigerant channel in the evaporator 2621 is connected to the input end of the compressor 2622. The water cooling system includes a large water tank 101, a water cooling channel in an evaporator 2621, and a heater 261. The large water tank 101, the water cooling channel in the evaporator 2621, and the heater 261 are connected through a pipe 20 to form a water cooling circulation loop. The first water inlet of the large water tank 101 is connected to the first external water supply unit, the first water outlet of the large water tank 101 is connected to the first external drainage unit, the second water outlet of the large water tank 101 is connected to the water inlet of the water cooling channel in the evaporator 2621, the water outlet of the water cooling channel in the evaporator 2621 is connected to the water inlet of the heater 261, and the water outlet of the heater 261 is connected to the second water inlet of the large water tank 101.

[0064] The refrigerant system and the water cooling system are used to heat up and cool down the water, and the refrigerant system and the water cooling system cooperate with each other to realize the cooling function and heating function of the temperature regulator 26.

[0065] In the refrigeration process of the refrigerant system, the compressor 2622 compresses the low-temperature and low-pressure refrigerant (i.e., refrigerant) gas in the refrigerant system that has been heat exchanged through the evaporator 2621 into a high-temperature and high-pressure gas, and enters the condenser 2623 through the pipeline 2620. The refrigerant releases heat in the condenser 2623, liquefies into a medium-temperature and high-pressure liquid, and then throttles and reduces pressure through the throttling device 2624, and enters the evaporator 2621 after becoming a low-temperature and medium-pressure gas-liquid mixed state. The refrigerant evaporates in the evaporator 2621, absorbs heat from the air, and becomes a high-temperature and low-pressure gas and returns to the compressor 2622, thereby completing a working cycle. In the above working cycle, the refrigerant absorbs the heat of the pipeline 20 when evaporating in the evaporator 2621, so that the temperature of the pipeline 20 is reduced, so the water flowing through the pipeline 20 is cooled; the refrigerant releases heat in the condenser 2623, and the heat is exported to the external environment through the condenser 2623. Compared with the semiconductor refrigeration method, the refrigerant system of this embodiment has a higher cooling efficiency. Due to the larger working power, when the large water tank 101 has a larger capacity to accommodate a larger number of water baths 10, the temperature of the water in the large water tank 101 can be better adjusted.

[0066] The refrigerant system may further include a fan 2625, which is used in conjunction with the condenser 2623 to allow wind to blow through the condenser 2623 to cool the refrigerant therein.

[0067] The throttling device 2624 is a capillary tube or a thermal expansion valve or an electronic expansion valve. The heater 261 can be an electric heating device that converts electrical energy into thermal energy, such as a resistance heater, an induction heater, an arc heater 261, an electron beam heater, an infrared heater, a dielectric heater, etc. Such heaters can directly generate heat inside the pipe 20 without relying on other intermediate media. Therefore, the thermal efficiency of the heater 261 is high, so that the water in the pipe 20 heats up faster, and the condition of the large water tank 101 can be adjusted in time. In addition, the heater 261 generates less exhaust gas, residues and smoke during operation, which can keep the surface of the pipe 20 clean and does not pollute the environment.

[0068] In some embodiments, the first water pump 103 is installed between the second water outlet of the large water tank 101 and the water inlet of the water cooling channel. In other embodiments, the first water pump 103 is installed between the water outlet of the water cooling channel and the second water inlet of the large water tank 101.

[0069] In some embodiments, see Figure 6 The water circulation thawing system 100 also includes a first filter 109, a first end of the first filter 109 is connected to the first external water supply unit through a pipe 20, and a second end of the first filter 109 is connected to the first solenoid valve through the pipe 20, thereby preventing impurities such as sand and stone in the water from entering the large water tank 101.

[0070] In some embodiments, the water circulation thawing system 100 also includes a second filter 35, a first end of the second filter 35 is connected to the second external water supply unit through a pipe 20, and a second end of the second filter 35 is connected to the third solenoid valve 31 through a pipe 20, thereby preventing impurities such as sand and stones in the water from entering the water bath 10, thereby avoiding the situation in which the plasma in the blood bag 60 is damaged during the melting process due to the flow of water and the stirring of impurities to collide with the blood bag, thereby reducing the occurrence of plasma leakage in the blood bag 60.

[0071] In some embodiments, the water circulation thawing system 100 further includes a liquid level sensor 1010, which is disposed in the large water tank 101 and is used to detect the liquid level in the large water tank 101. The user can check the liquid level value detected by the liquid level sensor 1010 to know whether the current water level in the large water tank 101 is normal, so that the user can make adjustments at any time.

[0072] The liquid level sensor 1010 can be a contact liquid level sensor or a non-contact liquid level sensor. When the liquid level sensor 1010 is a contact liquid level sensor such as a float liquid level transmitter, a magnetic liquid level transmitter, or a immersion liquid level transmitter, the liquid level sensor 1010 is disposed in the large water tank 101; when the liquid level sensor 1010 is a non-contact liquid level sensor such as an ultrasonic liquid level transmitter or a radar liquid level transmitter, the liquid level sensor 1010 can be disposed in the large water tank 101 or outside the large water tank 101.

[0073] The first solenoid valve 107 , the second solenoid valve 108 and the liquid level sensor 1010 cooperate with each other so that the water level in the large water tank 101 can be automatically adjusted. For example, when the liquid level sensor 1010 detects that the water level in the large water tank 101 has not reached a predetermined water level value, the first solenoid valve 107 automatically connects the water path according to the detection value of the liquid level sensor 1010, so that the water in the first external water supply unit enters the large water tank 101; when the liquid level sensor 1010 detects that the water level in the large water tank 101 has reached a predetermined water level value, the first solenoid valve 107 automatically closes the water path according to the detection value of the liquid level sensor 1010, so as to stop the water in the first external water supply unit from entering the large water tank 101; and when the liquid level sensor 1010 detects that the water level in the large water tank 101 has reached a maximum water level value, the second solenoid valve 108 automatically opens the water path according to the detection value of the liquid level sensor 1010, so that the water in the large water tank 101 flows out to the first external drainage unit, and closes the water path when the liquid level sensor 1010 detects that the water level in the large water tank 101 has reached a predetermined water level value.

[0074] In some embodiments, in addition to the large water tank 101 being provided with a liquid level sensor 1010, the water bath 10 is also provided with a corresponding liquid level sensor 341, which is used to detect the liquid level in the water bath 10. The user can check the liquid level value detected by the liquid level sensor 341 to know whether the current water level in the water bath 10 is normal, so that the user can make adjustments at any time. The type of the liquid level sensor 341 refers to the type of the liquid level sensor 1010 in the above embodiment.

[0075] In some embodiments, in addition to the large water tank 101 being provided with a liquid level sensor 1010, and the water bath 10 being provided with a liquid level sensor 341, the water tank 28 may also be provided with a liquid level sensor 342. The liquid level sensor 342 is used to detect the water level in the water tank 28. The type of the liquid level sensor 342 refers to the type of the liquid level sensor 1010 in the above embodiment.

[0076] The third solenoid valve 31 and the liquid level sensor 342 work in cooperation with each other so that the water level in the water tank 28 can be adjusted automatically. For example, when the liquid level sensor 342 detects that the water level in the water tank 28 has not reached the predetermined water level value, the third solenoid valve 31 automatically connects the water path according to the detection value of the liquid level sensor 342, so that the water in the second external water supply unit enters the water tank 28; when the liquid level sensor 342 detects that the water level in the water tank 28 has reached the predetermined water level value, the third solenoid valve 31 automatically closes the water path according to the detection value of the liquid level sensor 342, so as to stop the water in the second external water supply unit from entering the water tank 28.

[0077] The sixth solenoid valve 34, the second water pump 24 and the liquid level sensor 341 work in coordination with each other so that the water level in the water bath 10 can be automatically adjusted. For example, when the liquid level sensor 341 detects that the water level in the water bath 10 has not reached the predetermined water level value, the sixth solenoid valve 34 automatically connects the water path where it is located according to the detection value of the liquid level sensor 341, and turns on the second water pump 24, so that the water in the second external water supply unit enters the water bath 10 from the water storage tank 28 through the suction of the second water pump 24; when the liquid level sensor 341 detects that the water level in the water bath 10 has reached the predetermined water level value, the sixth solenoid valve 34 automatically closes the water path where it is located according to the detection value of the liquid level sensor 341, so as to stop the second water pump 24 from working.

[0078] The types of the liquid level sensors 341 and 342 refer to the type of the liquid level sensor 1010 in the above embodiment.

[0079] In some embodiments, the water circulation thawing system 100 also includes a temperature sensor 27, which is arranged in the large water tank 101. The temperature sensor 27 is used to detect the temperature of the water in the large water tank 101. The temperature regulator 26 adjusts the temperature of the water in the large water tank 101 according to the parameters detected by the temperature sensor 27.

[0080] Generally, the temperature in the environment where the plasma is melted is maintained at 4°C ± 2°C. If the temperature is too high, less or no cold precipitate will be precipitated from the plasma. If the temperature is too low, too much precipitation of other impurities in the plasma will be caused. The temperature sensor 27 can cooperate with the temperature regulator 26. The temperature regulator 26 processes the data detected by the temperature sensor 27 in real time by using the PID (Proportion-Integral-Differential) program. When the temperature sensor 27 detects that the temperature in the large water tank 101 is too high or too low, the temperature regulator 26 can timely and adaptively adjust the temperature of the water according to the detection value of the temperature sensor 27, which helps the temperature regulator 26 to accurately control the temperature of the water in the large water tank 101 and meet the requirements of low temperature and constant temperature during the preparation of cold precipitates.

[0081] The temperature sensor 27 can be a contact temperature sensor or a non-contact temperature sensor. When the temperature sensor 27 is a contact temperature sensor such as a bimetallic temperature sensor, a glass liquid temperature sensor, a pressure temperature sensor, a resistance temperature sensor, a thermistor sensor, a thermocouple sensor, etc., the temperature sensor 27 is arranged in the large water tank 101; when the temperature sensor 27 is a non-contact temperature sensor such as an optical temperature sensor, a radiation temperature sensor, a colorimetric temperature sensor, etc., the temperature sensor 27 can be arranged in the large water tank 101 or outside the large water tank 101.

[0082] In some embodiments, in addition to the temperature sensor 27 provided in the large water tank 101, the water bath 10 is also provided with a corresponding temperature sensor 25, and the temperature regulator 26 adjusts the temperature of the water in the large water tank 101 according to the parameters detected by the temperature sensor 25. Since the blood bag 60 is accommodated in the water bath 10, it is helpful to better control the preparation process of the cold precipitation by detecting the temperature of the water in the water bath 10. The type of the temperature sensor 25 refers to the type of the temperature sensor 27 in the above embodiment.

[0083] See also Figure 8 An embodiment of the present application provides a cold precipitate preparation apparatus 200, and the cold precipitate preparation apparatus 200 includes the water circulation thawing system 100 of any of the above embodiments.

[0084] In the cold precipitate preparation instrument 200 of the embodiment of the present application, the blood bag is placed in a water bath 10 for plasma melting, the water bath 10 is contained in a large water tank 101, the large water tank 101 forms a water circuit with the first water pump 103 through a pipe 20, the temperature regulator 26 is connected to the pipe 20 to adjust the temperature of the water flowing through the pipe 20, and the temperature-adjusted water is re-transported to the large water tank 101 via the first water pump 103 to meet the temperature requirements during the cold precipitate preparation process; in addition, the water circulation thawing system 100 improves the preparation efficiency of the cold precipitate by setting up multiple water baths 10; the multiple water baths 10 are independent of each other, so that the water baths 10 do not affect each other during operation, thereby avoiding the cross-contamination of blood bags 60 in different water baths 10 due to plasma leakage, thereby improving the safety of the cold precipitate.

[0085] The cryoprecipitate preparation apparatus 200 further includes a plurality of placement units 40 and a plurality of exhaust units 50. The placement unit 40 is a tray or hook for placing the empty bag in the double bag. Each placement unit 40 corresponds to each water bath 10 one by one and forms a height difference. The height of the water bath 10 from the ground is higher than the height of the placement unit 40 from the ground. The exhaust unit 40 is used to clamp the catheter and perform peristalsis to discharge the air in the blood bag 60 containing fresh frozen plasma in the external double bag through the catheter to the empty bag. Siphoning can only be performed after the air is exhausted.

[0086] The exhaust unit 50 can be a peristaltic pump. Since a certain height difference is formed between the placement unit 40 and the water bath 10, after the exhaust unit 50 discharges the air in the catheter, the cold precipitate preparation instrument 200 can use the siphon effect to make the plasma in the blood bag 60 in the water bath 10 flow out into the empty bag, so that the cold precipitate preparation instrument 200 uses the water bath siphon method to prepare cold precipitate.

[0087] The above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present application, and should all be included in the protection scope of the present application.

Claims

1. A water circulation thawing system, characterized in that: include: A large water tank, a first water pump, a temperature regulator and a plurality of pipes, wherein the first water inlet of the large water tank is used to communicate with a first external water supply unit through the pipe, the first water outlet of the large water tank is used to communicate with a first external drainage unit through the pipe, the second water outlet of the large water tank is connected to the water inlet of the temperature regulator through the pipe, the water outlet of the temperature regulator is connected to the second water inlet of the large water tank through the pipe to form a water circulation, and the first water pump is arranged between the pipes to provide power for the water circulation; A plurality of water baths, each of which is accommodated in the large water tank, and each of which is used to accommodate a blood bag. The water inlet of the water bath is connected to the second external water supply unit through the pipe, and the water outlet of the water bath is connected to the second external drainage unit through the pipe; A control valve assembly, the control valve assembly is arranged between the pipelines, and is used to control the on-off of the waterway between the first external water supply unit and the first water inlet of the large water tank, and is also used to control the on-off of the waterway between the first water outlet of the large water tank and the first external drainage unit, and is also used to control the on-off of the waterway between the second external water supply unit and the water inlet of the water bath, and is also used to control the on-off of the waterway between the water outlet of the water bath and the second external drainage unit; A plurality of water tanks, the plurality of water tanks corresponding to the plurality of water baths, the water tanks being respectively connected with the water inlet of the water bath, the water outlet of the water bath, the second external water supply unit, and the second external drainage unit through the pipelines; the water tanks are used to collect water discharged from the water bath and perform leakage and pollution detection on the water discharged from the water bath; when the water in the water tank is detected to be polluted, the control valve assembly is used to control the communication of the waterway between the water tank and the second external drainage unit to discharge the sewage.

2. The water circulation thawing system according to claim 1, characterized in that: The temperature regulator includes a refrigerant system and a water cooling system; The refrigerant system includes a compressor, a condenser, a throttling device, and a refrigerant channel in an evaporator connected by a pipeline to form a refrigerant circulation loop, the output end of the compressor is connected to the input end of the condenser, the output end of the condenser is connected to the input end of the throttling device, the output end of the throttling device is connected to the input end of the refrigerant channel, and the output end of the refrigerant channel is connected to the input end of the compressor; The water cooling system includes a large water tank, a water cooling channel in the evaporator and a heater, which are connected by pipes to form a water cooling circulation loop; the first water inlet of the large water tank is connected to the first external water supply unit, the first water outlet of the large water tank is connected to the first external drainage unit, the second water outlet of the large water tank is connected to the water inlet of the water cooling channel, the water outlet of the water cooling channel is connected to the water inlet of the heater, and the water outlet of the heater is connected to the second water inlet of the large water tank.

3. The water circulation thawing system according to claim 2, characterized in that: The first water pump is installed between the second water outlet of the large water tank and the water inlet of the water cooling channel or between the water outlet of the water cooling channel in the evaporator and the second water inlet of the large water tank.

4. The water circulation thawing system according to claim 1, characterized in that: The water circulation thawing system also includes a plurality of second water pumps corresponding to the plurality of water baths respectively. The water storage tank is connected to the water inlet of the second water pump through the pipeline, and the water outlet of the second water pump is connected to the water inlet of the water bath through the pipeline. The control valve assembly is used to control the on-off of the water path between the second external water supply unit and the water storage tank, and is also used to control the on-off of the water path between the water storage tank and the second external drainage unit, and is also used to control the on-off of the water path between the water storage tank and the water inlet of the second water pump, and is also used to control the on-off of the water path between the water outlet of the water bath and the water storage tank.

5. The water circulation thawing system according to claim 4, characterized in that: The drain outlet of the water tank is connected to the water inlet of the second water pump through the pipe, the water inlet of the water tank is connected to the second external water supply unit through the pipe, and the water outlet of the water tank is connected to the second external drainage unit through the pipe; the control valve assembly is used to control the connection and disconnection of the water path between the second external water supply unit and the water tank, and is also used to control the connection and disconnection of the water path between the water tank and the second external drainage unit, and is also used to control the connection and disconnection of the water path between the water tank and the water inlet of the second water pump, and is also used to control the connection and disconnection of the water path between the water outlet of the water bath and the water tank.

6. The water circulation thawing system according to claim 5, characterized in that: The control valve assembly includes a first solenoid valve, a second solenoid valve, a third solenoid valve, a fourth solenoid valve, a fifth solenoid valve and a sixth solenoid valve, wherein the first end of the first solenoid valve is connected to the first external water supply unit through the pipeline, and the second end of the first solenoid valve is connected to the first water inlet of the large water tank through the pipeline; the first end of the second solenoid valve is connected to the first external drainage unit through the pipeline, and the second end of the second solenoid valve is connected to the first water outlet of the large water tank through the pipeline; the first end of the third solenoid valve is connected to the second external water supply unit through the pipeline, and the third solenoid valve is connected to the first external water supply unit through the pipeline. the second end of the sixth solenoid valve is connected to the water inlet of the water pump through the pipe, the second end of the sixth solenoid valve is connected to the water inlet of the second water pump through the pipe, the second end of the sixth solenoid valve is also connected to the first end of the fifth solenoid valve through the pipe, and the second end of the fifth solenoid valve is connected to the water outlet of the water bath through the pipe.

7. The water circulation thawing system according to claim 1, characterized in that: The water circulation thawing system further comprises a temperature sensor, and the temperature sensor is arranged in the large water tank and / or the water bath.

8. The water circulation thawing system according to claim 1, characterized in that: The water circulation thawing system further comprises a liquid level sensor, and the liquid level sensor is arranged in the large water tank and / or the water bath tank.

9. The water circulation thawing system according to claim 1, characterized in that: The water circulation thawing system also includes a first filter and a second filter, wherein the first end of the first filter is connected to the first external water supply unit through the pipeline, and the second end of the first filter is connected to the control valve assembly through the pipeline; the first end of the second filter is connected to the second external water supply unit through the pipeline, and the second end of the second filter is connected to the control valve assembly through the pipeline.

10. A cryoprecipitate preparation apparatus, characterized in that: A water circulation thawing system comprising the water circulation thawing system according to any one of claims 1 to 9.

11. The cryoprecipitate preparation apparatus according to claim 10, characterized in that: It also includes multiple placement units and multiple exhaust units, the placement units are used to place empty bags of the external double-linked bags, the placement units correspond to the water baths one by one and form a height difference, the height of the water bath from the ground is higher than the height of the placement units from the ground, and the exhaust units are arranged between the water bath and the placement units, and are used to clamp the ducts of the external double-linked bags for exhaust.

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