In-line closed sampling device for highly active drugs

Abstract

The present invention relates to the field of fluidized bed technology, and in particular discloses an online sealed sampling device for highly active drugs, comprising a sampling cylinder having a sampling channel, a sampling valve stem arranged on the sampling channel, and a sampling tube arranged on the side of the sampling cylinder and connected to the sampling channel, wherein the sampling valve stem can move along the axial direction of the sampling cylinder so that its end and the inlet of the sampling cylinder form a blocking setting or an unsealing setting, the sampling tube is provided with a blocking structure that forms a blocking setting or an unsealing setting with its outlet, the sampling tube is detachably connected to a sampling bottle, the sampling bottle is provided with a first sampling cavity, the first sampling cavity is connected to the sampling tube, and the first sampling cavity is provided with a sealed structure that forms a blocking setting or an unsealing setting with its inlet. The above structure provides an online sealed sampling device for highly active drugs that has good sealing performance, no openings, and no leakage points.

Description

Technical Field

[0001] The invention relates to the technical field of fluidized beds, in particular to an online closed sampling device for highly active drugs. Background Art

[0002] At present, the occupational exposure limit (OEL) is the end limit value of occupational hazards, which refers to the permissible exposure level that workers can repeatedly contact for a long time in their occupational activities without causing acute or chronic harm to their health.

[0003] Meaning of OEB4: 10>OEL≥1 μg / m 3 That is, the workers are exposed to less than 10 μg / m 3 .

[0004] The online sealed sampling device for high-activity drugs in the prior art is not airtight enough, and there are leakage problems in each process, which is not conducive to the health of workers. For example, there are connection gaps on the cylinder body, the discharge method is not sealed, and the sampling port is open. Summary of the invention

[0005] In order to overcome the deficiencies of the prior art, the present invention provides an online sealed sampling device for highly active drugs which has good sealing performance, no open openings and no leakage points and is fully sealed.

[0006] In order to achieve the above-mentioned purpose, the technical solution adopted by the present invention is: an online closed sampling device for highly active drugs, comprising a sampling cylinder with a sampling channel, a sampling valve stem arranged on the sampling channel, and a sampling tube arranged on the side of the sampling cylinder and connected to the sampling channel, the sampling valve stem can move along the axial direction of the sampling cylinder so that its end and the inlet of the sampling cylinder form a blocking arrangement or an unsealing arrangement, the sampling tube is provided with a blocking structure that forms a blocking arrangement or an unsealing arrangement with its outlet, the sampling tube is detachably connected to a sampling bottle, the sampling bottle is provided with a first sampling cavity, the first sampling cavity is connected to the sampling tube, and the first sampling cavity is provided with a closed structure that forms a blocking arrangement or an unsealing arrangement with its inlet.

[0007] In the above technical scheme, the sampling bottle of the sampler in the prior art is open, and the materials will be exposed to the outside world during the sampling and inspection process. The closed sampler designed in this invention draws on the principle of αβ valve, and both ports are closed after separation, which minimizes the diffusion of materials to the outside world and blocks the contact between operators and materials.

[0008] As a further configuration of the present invention, the sealed structure includes a first push rod inserted into the first sampling chamber, one end of the first push rod can be sealed with the entrance of the first sampling chamber to form a blocking end, and the other end extends out of the first sampling chamber to form a driving end. A first return spring is sleeved on the first push rod, one end of the first return spring abuts against a first convex ring arranged on the inner wall of the first sampling chamber, and the other end abuts against a second convex ring arranged on the driving end. The first return spring drives the blocking end to be sealed and connected with the entrance of the first sampling chamber.

[0009] As a further configuration of the present invention, the blocking structure includes a second push rod arranged in the sampling tube and a support portion fixed on the inner wall of the sampling tube. One end of the second push rod can be sealed and connected to the outlet of the sampling tube to form a blocking end, and the other end is connected to the support portion through a second return spring to form a connecting end. The second return spring drives the blocking end to cooperate with the outlet seal of the sampling tube while also abutting against the first push rod to form a linkage configuration.

[0010] In the above technical solution, the first push rod passes through the first convex ring and is sealed and connected to the first convex ring through a sealing ring. The first push rod can move along its axial direction. When sampling is required, force is applied to the driving end to push the first push rod to move, so that the blocking end and the entrance of the first sampling chamber are unblocked. At this time, because the second push rod is abutted against the first push rod, when the first push rod moves, the second push rod will also move with it, so that the blocking end and the outlet pushed by the sampling are unblocked, so that it is convenient for the material to come out of the sampling tube and enter the first sampling chamber. After the material enters the first sampling chamber, the driving force is removed, and the first push rod is reset under the action of the first return spring to make the blocking end block the entrance of the first sampling chamber again to prevent the material in the first sampling chamber from leaking. The second push rod is reset under the action of the second return spring to block the outlet of the sampling tube again, so that the sampling tube is in a closed state again, and then the sampling bottle is removed for inspection. The whole process is a closed operation, which minimizes the diffusion of materials to the outside world and blocks the contact between operators and materials. The second return spring and the first return spring are both compression springs.

[0011] As a further configuration of the present invention, the space between the support portion and the outlet of the sampling tube constitutes a second sampling cavity, and the support portion is provided with a through hole connecting the second sampling cavity and the sampling tube.

[0012] In the above technical solution, in order to facilitate the processing of the blocking structure, the part with the blocking structure is separated from the other parts of the sampling tube to form a sampling bottle joint. The sampling bottle joint and the tube wall of the sampling tube are connected by a clamp or a flange, or other fixed connection methods such as welding. The sampling bottle joint and the sampling bottle are detachably connected by a clamp or a flange, and the through hole is provided so that the material in the sampling tube can enter the second sampling cavity.

[0013] As a further configuration of the present invention, the support portion includes a support block for the second return spring to abut against and a connecting rod for fixing the support block on the sampling tube, and a gap exists between the circumferential surface of the support block and the inner wall of the sampling tube to form the through hole.

[0014] In the above technical solution, the support block is suspended in the second sampling cavity through connecting rods. Preferably, the connecting rods are located on the corresponding two sides of the support block. Of course, there can be more than one connecting rod, as long as through holes are left.

[0015] As a further configuration of the present invention, the support block includes a conical head and a cylindrical tail, the bottom surface of the head faces the tail and is integrally connected with the tail, the tail is provided with a concave cavity for inserting the second push rod, and the second return spring is located between the bottom surface of the concave cavity and the second push rod.

[0016] In the above technical solution, the conical head is set to play a guiding role to prevent the support part from obstructing the passage of materials. The inner diameter of the concave cavity is adapted to the outer diameter of the second push rod. The second push rod is embedded in the concave cavity. The concave cavity has both a guiding and limiting effect on the second push rod.

[0017] As a further configuration of the present invention, a first conical surface and a second conical surface that match each other are respectively arranged between the blocking end of the second push rod and the outlet of the sampling tube, the inclination angles of the first conical surface and the second conical surface are consistent, and the second push rod is driven by the second return spring to move toward the direction close to the first push rod so that the first conical surface abuts against the second conical surface.

[0018] In the above technical solution, because the blocking end and the outlet of the sampling tube are sealed, there must be a contact surface between the two, and the contact surface is the first conical surface and the second conical surface. The contact surface is arranged as a conical surface, which can make the blocking end and the inner wall at the outlet of the sampling tube abut more tightly and reliably, and the end with a smaller diameter on the second conical surface faces the sampling bottle.

[0019] As a further configuration of the present invention, a third conical surface and a fourth conical surface that match each other are respectively arranged between the blocking end of the first push rod and the entrance of the first sampling chamber, and the inclination angles of the third conical surface and the fourth conical surface are consistent. Driven by the first return spring, the first push rod moves in a direction away from the second push rod so that the third conical surface abuts against the fourth conical surface.

[0020] In the above technical solution, because the blocking end and the entrance of the first sampling cavity are blocked, there must be a contact surface between the two, and the contact surface is the third conical surface and the fourth conical surface. The contact surface is arranged as a conical surface, which can make the blocking end and the inner wall at the entrance of the first sampling cavity abut more tightly and reliably. The end with a larger diameter on the fourth conical surface faces the sampling bottle connector.

[0021] As a further configuration of the present invention, the diameter of the larger end of the third conical surface is equal to or smaller than the diameter of the smaller end of the second conical surface.

[0022] In the above technical solution, since the blocking end needs to enter the sampling bottle connector to push the second push rod, and the blocking end is truncated cone-shaped, and the third conical surface is the circumferential surface of the truncated cone, the maximum diameter of the blocking end must be less than or equal to the minimum diameter of the second conical surface.

[0023] As a further configuration of the present invention, a fifth conical surface and a sixth conical surface that match each other are respectively arranged between one end of the sampling valve stem and the inlet of the sampling cylinder, and the other end extends out of the sampling cylinder to form a handle. The inclination angles of the fifth conical surface and the sixth conical surface are consistent. A third return spring is sleeved on the sampling valve stem, one end of the third return spring abuts against a first convex portion arranged on the inner wall of the sampling cylinder, and the other end abuts against a second convex portion arranged on the outer circumferential surface of the sampling valve stem. Driven by the third return spring, the fifth conical surface moves along its axial direction so that the fifth conical surface abuts against the sixth conical surface.

[0024] In the above technical scheme, anti-tumor, hormone, sensitizing and other highly active drugs need to strictly avoid drug powder exposure during sampling and testing to prevent operators from long-term exposure to harmful health. When sampling, push the sampling valve stem inward or pull the sampling valve stem outward, the inlet end of the sampling cylinder is opened, that is, the valve mouth is opened, and the drug powder enters the sampling cylinder from the silo, flows through the sampling channel to the sampling tube and finally falls into the second sampling cavity. Release the handle, and the sampling valve stem is reset under the action of the third reset spring, the valve mouth is closed, and then the first push rod is pushed upward to drive the second push rod to move upward together. The mouth of the sampling bottle opens, and the drug powder falls into the first sampling cavity. Release the driving end, and the first push rod and the second push rod are reset under the joint action of the first reset spring and the second reset spring. The bottle mouth is closed, the clamp is released, and the sampling bottle is removed. Both ends are closed, and there is no drug powder residue on the end surface, thereby ensuring that the operator does not touch the drug powder during sampling and inspection.

[0025] As a further configuration of the present invention, a cover plate is provided on the end of the sampling cylinder body opposite to the inlet thereof, and the handle passes through the cover plate to be exposed.

[0026] In the above technical solution, the cover plate is preferably sealed with the sampling valve stem to avoid material leakage.

[0027] As a further configuration of the present invention, a partition is provided in the sampling channel of the sampling cylinder, and the sampling valve stem passes through the partition and is sealed with the partition, so the partition constitutes the first convex portion.

[0028] In the above technical solution, the partition plate and the sampling valve stem are sealed and connected by a sealing ring to further prevent material leakage. The sampling channel has a double seal to improve the airtightness during the sampling process.

[0029] The present invention will be further described below in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Attached Figure 1 It is a structural cross-sectional view of a closed sampler of a specific embodiment of the present invention when sampling;

[0031] Attached Figure 2 It is a structural cross-sectional view of the closed sampler of a specific embodiment of the present invention when not sampling;

[0032] Attached Figure 3 It is a structural cross-sectional diagram of a sampling bottle according to a specific embodiment of the present invention. DETAILED DESCRIPTION

[0033] The specific implementation example of the present invention is Figure 1-3 As shown, an online closed sampling device for highly active drugs comprises a sampling barrel 1 having a sampling channel 11, a sampling valve stem 2 arranged on the sampling channel 11, and a sampling tube 3 arranged on the side of the sampling barrel 1 and connected to the sampling channel 11, wherein the sampling valve stem 2 can move along the axial direction of the sampling barrel 1 so that its end portion and the inlet of the sampling barrel 1 form a blocking arrangement or an unsealing arrangement, the sampling tube 3 is provided with a blocking structure that forms a blocking arrangement or an unsealing arrangement with its outlet, the sampling tube 3 is detachably connected to a sampling bottle 4, the sampling bottle 4 is provided with a first sampling cavity 41, the first sampling cavity 41 is connected to the sampling tube 3, and the first sampling cavity 41 is provided with a closed structure that forms a blocking arrangement or an unsealing arrangement with its inlet. In the sampler in the prior art, the sampling bottle 4 is open, and the materials will be exposed to the outside during the sampling and inspection process. However, the closed sampling device designed in this invention draws on the principle of αβ valve, and both ports are closed after separation, which minimizes the diffusion of materials to the outside and blocks the contact between operators and materials.

[0034] The above-mentioned closed structure includes a first push rod 42 inserted into the first sampling cavity 41, one end of the first push rod 42 can be sealed with the entrance of the first sampling cavity 41 to form a blocking end 421, and the other end extends out of the first sampling cavity 41 to form a driving end 422. A first return spring 43 is sleeved on the first push rod 42, one end of the first return spring 43 abuts against a first convex ring 44 arranged on the inner wall of the first sampling cavity 41, and the other end abuts against a second convex ring 45 arranged on the driving end 422. The first return spring 43 drives the blocking end 421 to be sealed and connected with the entrance of the first sampling cavity 41.

[0035] The above-mentioned blocking structure includes a second push rod 31 arranged in the sampling tube 3 and a support part 32 fixed on the inner wall of the sampling tube 3. One end of the second push rod 31 can be sealed and connected with the outlet of the sampling tube 3 to form a blocking end 311, and the other end is connected to the support part 32 through a second return spring 33 to form a connecting end 312. The second return spring 33 drives the blocking end 311 to cooperate with the outlet seal of the sampling tube 3 while also abutting against the first push rod 42 to form a linkage setting. The first push rod 42 passes through the first convex ring 44 and is sealed and connected to the first convex ring 44 through the sealing ring 01. The first push rod 42 can move along its axial direction. When sampling is required, force is applied to the driving end 422 to push the first push rod 42 to move, so that the blocking end 421 and the entrance of the first sampling chamber 41 are unblocked. At this time, because the second push rod 31 is abutted against the first push rod 42, when the first push rod 42 moves, the second push rod 31 will also move, so that the blocking end 311 and the outlet of the sampling push are unblocked, so that the material comes out of the sampling tube 3 and enters the first sampling chamber 41. When the material enters After entering the first sampling chamber 41, the driving force is removed, and the first push rod 42 is reset under the action of the first reset spring 43 so that the blocking end 421 is blocked at the entrance of the first sampling chamber 41 again to prevent the material in the first sampling chamber 41 from leaking. The second push rod 31 is reset under the action of the second reset spring 33 and is blocked at the outlet of the sampling tube 3 again, so that the sampling tube 3 is in a closed state again, and then the sampling bottle 4 is removed for inspection. The whole process is a closed operation, which minimizes the diffusion of materials to the outside and blocks the contact between operators and materials. The second reset spring 33 and the first reset spring 43 are both compression springs.

[0036] The space between the support part 32 and the outlet of the sampling tube 3 constitutes the second sampling cavity 34, and the support part 32 is provided with a through hole 35 connecting the second sampling cavity 34 and the sampling tube 3. In order to facilitate the processing of the blocking structure, the part with the blocking structure is separated from the other parts of the sampling tube 3 to form a sampling bottle joint 5. The sampling bottle joint 5 and the tube wall with the sampling tube 3 are connected by a clamp or a flange, or by other fixed connection methods such as welding. The sampling bottle joint 5 and the sampling bottle 4 are detachably connected by a clamp or a flange, and the through hole 35 is provided so that the material in the sampling tube 3 can enter the second sampling cavity 34.

[0037] The support part 32 includes a support block 321 for the second return spring 33 to abut against and a connecting rod 322 for fixing the support block 321 on the sampling tube 3. There is a gap between the circumferential surface of the support block 321 and the inner wall of the sampling tube 3 to form the through hole 35. The support block 321 is suspended in the second sampling cavity 34 by the connecting rod 322. Preferably, the connecting rod 322 is located on the corresponding two sides of the support block 321. Of course, more connecting rods 322 can be provided, as long as the through hole 35 is reserved.

[0038] The support block 321 includes a conical head 3211 and a cylindrical tail 3212. The bottom surface of the head 3211 faces the tail 3212 and is integrally connected with the tail 3212. The tail 3212 is provided with a concave cavity 3212a for the second push rod 31 to be inserted. The second return spring 33 is located between the bottom surface of the concave cavity 3212a and the second push rod 31. The conical configuration of the head 3211 is to play a guiding role to prevent the support portion 32 from obstructing the passage of materials. The inner diameter of the concave cavity 3212a is adapted to the outer diameter of the second push rod 31. The second push rod 31 is embedded in the concave cavity 3212a. The concave cavity 3212a has both a guiding role and a limiting role for the second push rod 31.

[0039] A first conical surface 3111 and a second conical surface 38 that match each other are respectively arranged between the blocking end 311 of the second push rod 31 and the outlet of the sampling tube 3. The first conical surface 3111 and the second conical surface 38 have the same inclination angle. The second push rod 31 moves toward the direction close to the first push rod 42 under the drive of the second return spring 33 so that the first conical surface 3111 abuts against the second conical surface 38. Because the blocking end 311 and the outlet of the sampling tube 3 are sealed, there must be a contact surface between the two, and the contact surface is the first conical surface 3111 and the second conical surface 38. The contact surface is arranged in a conical surface, which can make the blocking end 311 and the inner wall at the outlet of the sampling tube 3 abut more tightly and reliably. The end with a smaller diameter on the second conical surface 38 faces the sampling bottle 4.

[0040] A third conical surface 4211 and a fourth conical surface 46 are provided between the blocking end 421 of the first push rod 42 and the entrance of the first sampling chamber 41. The third conical surface 4211 and the fourth conical surface 46 have the same inclination angle. The first push rod 42 moves away from the second push rod 31 under the drive of the first return spring 43 so that the third conical surface 4211 abuts against the fourth conical surface 46. Because the blocking end 421 and the entrance of the first sampling chamber 41 are blocked, there must be a contact surface between the two, and the contact surface is the third conical surface 4211 and the fourth conical surface 46. The contact surface is provided as a conical surface, which can make the blocking end 421 and the inner wall at the entrance of the first sampling chamber 41 abut more tightly and reliably. The end with a larger diameter on the fourth conical surface 46 faces the sampling bottle connector 5.

[0041] The diameter of the larger end of the third conical surface 4211 is equal to or smaller than the diameter of the smaller end of the second conical surface 38. Since the plugging end 421 needs to enter the sampling bottle connector 5 to push the second push rod 31, and the plugging end 421 is in a truncated cone shape, and the third conical surface 4211 is the circumferential surface of the truncated cone, the maximum diameter of the plugging end 421 must be smaller than or equal to the minimum diameter of the second conical surface 38.

[0042] A fifth conical surface 21 and a sixth conical surface 12 that match each other are respectively arranged between one end 22 of the sampling valve stem 2 and the inlet of the sampling cylinder 1, and the other end extends out of the sampling cylinder 1 to form a handle 23. The inclination angles of the fifth conical surface 21 and the sixth conical surface 12 are consistent. A third return spring 24 is sleeved on the sampling valve stem 2, and one end of the third return spring 24 abuts against a first convex portion 13 arranged on the inner wall of the sampling cylinder 1, and the other end abuts against a second convex portion 25 arranged on the outer circumferential surface of the sampling valve stem 2. The second convex portion 25 is composed of a nut and a gasket. Driven by the third return spring 24, the fifth conical surface 21 moves along its axial direction so that the fifth conical surface 21 abuts against the sixth conical surface 12. When sampling and testing highly active drugs such as anti-tumor, hormone, and sensitizing drugs, it is necessary to strictly avoid drug powder exposure to prevent operators from long-term exposure to harmful health. When sampling, push the sampling valve stem 2 inward or pull it outward, the inlet end of the sampling cylinder 1 is opened, that is, the valve port is opened, and the drug powder enters the sampling cylinder 1 from the silo, flows to the sampling tube 3 through the sampling channel 11, and finally falls into the second sampling cavity 34. Release the handle 23, and the sampling valve stem 2 is reset under the action of the third reset spring 24, and the valve port is closed. Then push the first push rod 42 upward to drive the second push rod 31 to move upward together, and the mouth of the sampling bottle 4 is opened. The drug powder falls into the first sampling cavity 41, and release the driving end 422. Under the joint action of the first reset spring 43 and the second reset spring 33, the first push rod 42 and the second push rod 31 are reset, and the bottle mouth is closed. Release the clamp, remove the sampling bottle 4, and both ends are closed. There is no drug powder residue on the end surface, thereby ensuring that the operator does not touch the drug powder during the sampling and inspection process.

[0043] The end of the sampling cylinder 1 opposite to the inlet is covered with a cover plate 14, and the handle 23 is exposed through the cover plate 14. Preferably, the cover plate 14 is in sealing cooperation with the sampling valve stem 2 to prevent material leakage.

[0044] A partition 13 is provided in the sampling channel 11 of the sampling cylinder 1, and the sampling valve stem 2 passes through the partition 13 and seals with it, so the partition 13 constitutes the first convex portion 13. The partition 13 and the sampling valve stem 2 are sealed and connected via a sealing ring 15 to further prevent material leakage. The sampling channel 11 has a double seal to improve the airtightness during the sampling process.

[0045] The present invention is not limited to the above-mentioned specific implementation modes. A person skilled in the art may adopt other various specific implementation modes to implement the present invention based on the contents disclosed in the present invention, or any simple changes or modifications made to the design structure and concept of the present invention shall fall within the protection scope of the present invention.

Claims

1. An online closed sampling device for highly active drugs, characterized in that: The invention comprises a sampling cylinder having a sampling channel, a sampling valve stem arranged on the sampling channel, and a sampling tube arranged on the side of the sampling cylinder and connected to the sampling channel, wherein the sampling valve stem can move along the axial direction of the sampling cylinder so that its end and the inlet of the sampling cylinder form a blocking arrangement or an unsealing arrangement, the sampling tube is provided with a blocking structure which forms a blocking arrangement or an unsealing arrangement with its outlet, the sampling tube is detachably connected to a sampling bottle, the sampling bottle is provided with a first sampling cavity, the first sampling cavity is connected to the sampling tube, and the first sampling cavity is provided with a sealing structure which forms a blocking arrangement or an unsealing arrangement with its inlet; the sealing structure comprises a sealing structure which is penetrated through the first sampling cavity and is provided with a sealing structure which forms a blocking arrangement or an unsealing arrangement with its inlet; The first push rod on the cavity, one end of the first push rod can be sealed with the entrance of the first sampling cavity to form a blocking end, and the other end extends out of the first sampling cavity to form a driving end. A first return spring is sleeved on the first push rod. One end of the first return spring abuts against a first convex ring arranged on the inner wall of the first sampling cavity, and the other end abuts against a second convex ring arranged on the driving end. The first return spring drives the blocking end to be sealed and connected with the entrance of the first sampling cavity; the blocking structure includes a second push rod arranged in the sampling tube and a supporting part fixed on the inner wall of the sampling tube, one end of the second push rod can be sealed and connected with the outlet of the sampling tube to form a blocking end, and the other end The support part is connected by a second return spring to form a connecting end, and the second return spring drives the blocking end to seal with the outlet of the sampling tube and also abuts against the first push rod to form a linkage arrangement; the space between the support part and the outlet of the sampling tube constitutes a second sampling cavity, and the support part is provided with a through hole connecting the second sampling cavity and the sampling tube; the support part includes a support block for abutment of the second return spring and a connecting rod for fixing the support block on the sampling tube, and there is a gap between the circumferential surface of the support block and the inner wall of the sampling tube to form the through hole; the support block includes a conical head and a cylindrical tail, and the bottom surface of the head faces the tail and is integrally connected with the tail The tail portion is provided with a concave cavity for inserting the second push rod, and the second return spring is located between the bottom surface of the concave cavity and the second push rod; a first conical surface and a second conical surface that match each other are respectively provided between the blocking end of the second push rod and the outlet of the sampling tube, and the inclination angles of the first conical surface and the second conical surface are consistent. The second push rod is driven by the second return spring to move toward the direction approaching the first push rod so that the first conical surface abuts against the second conical surface; a sampling bottle connector is provided between the sampling tube and the sampling bottle, one end of the sampling bottle connector is connected to the sampling tube, and the other end forms a detachable connection with the sampling bottle to connect the sampling tube and the sampling bottle.

2. The online closed sampling device for highly active drugs according to claim 1, characterized in that: A third conical surface and a fourth conical surface that match each other are respectively arranged between the blocking end of the first push rod and the entrance of the first sampling chamber. The inclination angles of the third conical surface and the fourth conical surface are consistent. The first push rod is driven by the first return spring to move in a direction away from the second push rod so that the third conical surface abuts against the fourth conical surface.

3. The online closed sampling device for highly active drugs according to claim 2, characterized in that: The diameter of the larger end of the third conical surface is equal to or smaller than the diameter of the smaller end of the second conical surface.

4. The online closed sampling device for highly active drugs according to claim 2 or 3, characterized in that: A fifth conical surface and a sixth conical surface that match each other are respectively arranged between one end of the sampling valve stem and the inlet of the sampling cylinder, and the other end extends out of the sampling cylinder to form a handle. The inclination angles of the fifth conical surface and the sixth conical surface are consistent. A third return spring is sleeved on the sampling valve stem, one end of the third return spring abuts against a first convex portion arranged on the inner wall of the sampling cylinder, and the other end abuts against a second convex portion arranged on the outer circumferential surface of the sampling valve stem. Driven by the third return spring, the fifth conical surface moves along its axial direction so that the fifth conical surface abuts against the sixth conical surface.

5. The online closed sampling device for highly active drugs according to claim 4, characterized in that: The end of the sampling cylinder body opposite to the inlet is covered with a cover plate, and the handle passes through the cover plate to be exposed.

6. The online closed sampling device for highly active drugs according to claim 4, characterized in that: A partition is arranged in the sampling channel of the sampling cylinder, and the sampling valve stem passes through the partition and is sealed with the partition, so the partition constitutes the first convex part.

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