A multi-concentration synchronous and precise control of poisoning experimental device

Abstract

The present invention provides a multi-concentration synchronous and precise control poisoning experimental device, comprising a liquid supply system controlled by a main control computer installed on a support frame, wherein a stepper motor drives a multi-stage pump body to transport the poisoning agent in the poisoning agent bottle to a poisoning system composed of several poisoning chambers for holding experimental animals at different rates, each poisoning chamber is sealed and connected to an atomizing nozzle and a gas-liquid mixer at the top, one end of each gas-liquid mixer is connected to the gas source cylinder of the gas supply system through an airflow controller to provide a dedicated gas source for high-pressure atomization, and the other end is connected to the liquid supply system to provide atomized aerosols of different concentrations formed by atomization of the poisoning agent at different rates to perform multi-concentration synchronous and precise control poisoning experiments on experimental animals in respective poisoning chambers. The beneficial effects of the present invention are: multiple concentration synchronous inhalation poisoning experiments can be accurately carried out simultaneously, meeting the scientific research experimental purposes of inhalation poisoning operation standardization and synchronous and precise control.

Description

Technical Field

[0001] The invention relates to a multi-concentration synchronous and precise control poisoning experimental device. Background Art

[0002] With the development of scientific research on respiratory diseases, more and more pathological studies need to conduct respiratory toxicity experiments to verify the degree of harmful effects of certain gaseous substances, liquid substances, etc. on humans. For the testing of multi-concentration poisoning experiments, previous technologies require the use of multiple independent poisoning experimental equipment to complete the experiment at the same time or a single device to complete the experiment in multiple times. If multiple devices are used, a large laboratory space will be occupied and the cost will be too high; if a single device is used to do it in batches, it will take a long time and the conditions will be slightly different, then the scientificity and accuracy of the experiment cannot be guaranteed, which brings irreconcilable contradictions to scientific research institutions and the application of scientific experiments. In order not to take up more space, reduce the funds for purchasing multiple experimental equipment, and shorten the experimental time, it is possible to carry out multi-concentration synchronous and precisely controlled poisoning experiments on a poisoning device at any time. Therefore, the development of a multi-concentration synchronous and precisely controlled poisoning experiment has become an urgent need. Summary of the invention

[0003] In order to solve the above problems, the purpose of the present invention is to provide a multi-concentration synchronous and precise control of poisoning experimental device, which adopts a computer-controlled stepper motor to drive a multi-stage pump body to transport the poisoning agent at different rates to a poisoning system composed of several poisoning chambers of the same shape and volume, so as to form atomized aerosols of different concentrations in the poisoning chambers to carry out multi-concentration synchronous and precise control of poisoning experiments on experimental animals.

[0004] To achieve the above-mentioned purpose, the technical scheme of the present invention is to provide a multi-concentration synchronous precise control poisoning experimental device, including a supporting frame with elastic foot pads, on which a main control computer and a liquid supply system, an air supply system and a poisoning system under its control are installed. The stepper motor of the liquid supply system drives a multi-stage pump body to transport the poisoning agent in the poisoning agent bottle installed on the supporting frame at different rates to the poisoning system composed of a number of poisoning chambers of the same shape and volume also installed on the supporting frame. A lockable valve and a breathable partition for holding experimental animals are opened in the middle of each poisoning chamber, and a filter air valve and an exhaust gas discharge pipe are sealed at the bottom of each poisoning chamber. Each poisoning chamber is sealed with an atomizing nozzle and a gas-liquid mixer on the top. One end of each gas-liquid mixer is connected to the filter diverter and gas source cylinder of the gas supply system through a closed gas pipe and an air flow controller, providing the poisoning chamber with a fresh, special gas source for high-pressure atomization, while the other end of the gas-liquid mixer is connected to the multi-stage pump body of the liquid supply system through a closed infusion tube, and the poisoning agent required for poison atomization is provided to the poisoning chamber through the pipette in the poisoning agent bottle. Under the control of the main control computer, atomized aerosols of different concentrations formed by the poisoning agent are provided at different rates to carry out poisoning experiments on experimental animals in the poisoning chamber with multi-concentration synchronous and precise control.

[0005] The beneficial effect of the present invention is that the experimental device can accurately and simultaneously carry out inhalation poisoning experiments with multiple concentrations, meeting the scientific research experimental objectives of inhalation poisoning operation standardization and synchronous precise control. BRIEF DESCRIPTION OF THE DRAWINGS

[0006] Attached Figure 1 It is a schematic diagram of the structure of the present invention.

[0007] In the figure:

[0008] 1. Filter air valve 2. Experimental animals 3. Cabin bracket 4. V-shaped lower plate 5. Contaminated cabin 6. Breathable partition

[0009] 7. Atomizing aerosol 8. Atomizing nozzle 9. Conical cover 10. Gas-liquid mixer 11. Gas pipe 12. Air flow controller

[0010] 13. Branch gas pipe 14. Gas cylinder fixing bracket 15. Gas source cylinder 16. Gas supply system 17. Pressure reducing valve 18. Flow meter

[0011] 19. Main air pipe 20. Filter diverter 21. Motor bracket 22. Stepper motor 23. Motor spindle 24. Peristaltic roller

[0012] 25. Multi-stage pump body 26. Pump pipe gland 27. Pump head bracket 28. Low-speed pump head 29. Pump head bearing 30. Pump head spindle

[0013] 31. Fastening bolts 32. Peristaltic pump tube 33. Pump tube connector 34. Infusion tube 35. Liquid supply system 36. Bracket stand

[0014] 37. Roller wheel 38. Poisoning agent 39. Poisoning agent bottle 40. Elastic foot pad 41. Pipette 42. Main control computer

[0015] 43. Control bus 44. Table plate 45. Bracket screws 46. Support stand 47. Infection system 48. Lockable valve

[0016] 49. Lower air outlet pipe 50. Exhaust gas discharge pipe. DETAILED DESCRIPTION

[0017] Combined with Figure 1 The present invention is described with reference to the accompanying drawings and examples.

[0018] As attached Figure 1As shown, the present invention provides a multi-concentration synchronous precise control poisoning experimental device, including a support stand 46 with an elastic foot pad 40, on which a main control computer 42 and a liquid supply system 35, an air supply system 16 and a poisoning system 47 under its control are installed. The liquid supply system 35 is a stepper motor 22 under the control of the main control computer 42 connected to a motor main shaft 23 to drive a multi-stage pump body 25, and an infusion tube 34 is connected to a peristaltic pump tube 32 and a pipette 41 through a pump tube joint 33 to transport the poisoning agent 38 in the poisoning agent bottle 39 to different poisoning chambers 5 in the poisoning system 47 at different rates to perform multi-concentration synchronous precise control on the experimental animal 2. The invention relates to a special device for controlling poisoning experiments, wherein a stepper motor 22 is fixedly mounted on the middle of a support stand 36 of a support stand 46 by a motor bracket 21. The stepper motor 22 drives a multi-stage pump body 25 fixedly mounted on the right side of the support stand 36 of the support stand 46 by a pump head bracket 27 at a precise rotation speed under the control of a main control computer 42. The multi-stage pump body 25 is a device in which a plurality of individual pump bodies are stacked together and coaxially mounted on a pump head spindle 30, and the speed is reduced in a certain proportion from a high-speed pump head to a low-speed pump head 28 with the lowest speed. One end of the multi-stage pump body 25 is connected to the motor spindle 23 of the stepper motor 22. The multi-stage pump body 25 is controlled by a main control computer 42. The motor 22 drives the multi-stage pump body 25 to rotate synchronously to work or stop, and the pump head main shaft 30 at the other end of the multi-stage pump body 25 engages with the pump head bearing 29 to connect the pump head bracket 27 and is fixed to the right side of the bracket vertical plate 36 of the support stand 46 through the fastening bolts 31. With stable operation or stop, several pump heads with different radii of the multi-stage pump body 25 are superimposed and coaxially installed on the same pump head main shaft 30 in sequence, and each pump head has a pump pipe gland 26 with the same circle as the outer circumference on the outer circumference, and the lower side of the pump pipe gland 26 is a disc-shaped roller wheel 37, and the peristaltic rollers 24 are evenly distributed around the outer circumference of the roller wheel 37 at equal distances. The roller wheel 37 is on the pump head main shaft The shaft 30 drives the peristaltic roller 24 to make a circular motion, and the roller disc 37 also rotates freely at the same time. A taut peristaltic pump tube 32 is installed on the peristaltic roller 24. The negative pressure formed by the squeezing and kneading of the peristaltic roller 24 and the pump tube gland 26 drives the liquid in the peristaltic pump tube 32 to be transported. When the stepper motor 22 drives the multi-stage pump body 25 to rotate under the precise speed control of the main control computer 42, the pump heads of each level, whether high-speed or low-speed, rotate at the same angular velocity, and the linear velocity of the peristaltic roller 24 of each different pump head on the circumference of the roller disc 37 is the product of its angular velocity and radius, so the larger the radius of the pump head, the greater the rate at which the liquid is transported.Each peristaltic pump tube 32 of the multi-stage pump body 25 is driven by the multi-stage pump body 25, and the pipette 41 connected to the pump pipe joint 33 transmits the poisoning agent 38 in the poisoning agent bottle 39 placed on the table plate 44 of the support stand 46 at different rates through the pump pipe joint 33 and the infusion tube 34 on the other side to the poisoning system 47 composed of a plurality of poisoning cabins 5 of the same shape and volume installed on the support stand 46 to perform a multi-concentration synchronous and precisely controlled poisoning experiment under the control of the main control computer 42; the air supply system 16 is composed of a special high-pressure resistant gas source cylinder 15, a filter diverter 20 and a plurality of airflow controllers 12, and is connected to different poisoning cabins 5 through the air supply pipe 11 to supply gas and liquid under the control of the main control computer 42. The mixer 10 provides a control device for a special gas source for high-pressure atomization. One end of a main gas pipe 19 for main input is connected to the gas source cylinder 15, and the other end is sealed and connected to the filter diverter 20. It is made of a sealed rigid shell wrapped with a special uniform and dense multi-porous ceramic fiber and a double-layer gas transmission diverter layer of nano-adsorbent material and a plurality of diverter outlets. It is used to filter any particulate matter and impurities in the gas and evenly distribute the special gas that can pass through to each output branch gas pipe 13. The gas source cylinder 15 is fixedly installed on the left side wall of the bracket vertical plate 36 through the gas cylinder fixing frame 14. The gas in the gas source cylinder 15 enters the filter diverter 20 through the main gas pipe 19 after the pressure reducing valve 17 and the flow meter 18 are adjusted to reach the required pressure value. Filter 20 is filtered The diverted flow then enters a number of airflow controllers 12 under the control of a main control computer 42 through a branch air pipe 13, and the airflow adjusted according to the required flow rate of each poisoning cabin 5 is transmitted to a gas-liquid mixer 10 and an atomizing nozzle 8 under the control of the main control computer 42 to atomize the poisoning agent 38 into an atomized aerosol 7; the poisoning system 47 is a poisoning experiment execution device composed of a number of poisoning cabins 5 of the same shape and volume mounted on a table top plate 44 of a support stand 46 through a cabin bracket 3, the poisoning cabin 5 is a cylindrical hollow cabin made of transparent, non-toxic, odorless, strong and corrosion-resistant material, with a lockable valve 48 in the middle, the lower part of the poisoning cabin 5 is sealed and connected to a V-shaped lower plate 4, and a container for holding experimental animals 2 is placed on the V-shaped lower plate 4. The air permeable partition 6 and the V-shaped lower plate 4 are sealedly connected to the filter air valve 1 and the exhaust gas discharge pipe 50 controlled by the main control computer 42 through the lower air outlet pipe 49 in the middle. The contaminated cabin 5 is sealedly connected to the conical upper cover 9. The middle of the upper cover has a gas-liquid mixer 10 connected to the atomizing nozzle 8. One end of the gas-liquid mixer 10 is connected to the filter diverter 20 and the gas source cylinder 15 of the air supply system 16 through a closed air supply pipe 11 and an air flow controller 12 to provide the contaminated cabin 5 with a fresh special gas source for high-pressure atomization. The other end is connected to the infusion pipe 34 provided by the liquid supply system 35. Each contaminated cabin 5 is connected to the peristaltic pump tube 32 in different pump heads of the multi-stage pump body 25 of the liquid supply system 35 through the infusion pipe 34 and the pump pipe joint 33.By providing the poisoning agent 38 required for poisoning atomization to the poisoning chamber 5 through the pipette 41 in the poisoning agent bottle 39, it is possible to provide atomized aerosols 7 of different concentrations formed by the poisoning agent 38 at different rates to carry out a multi-concentration synchronous and precisely controlled poisoning experiment on the experimental animal 2 in the poisoning chamber 5; the support stand 46 is a table-type stand made of a strong, corrosion-resistant, rigid material that can support a plurality of functional components, the rear portion of the support stand 46 is vertically connected to the stand plate 36 with the table top plate 44, the right side wall of the stand plate 36 is fixedly mounted with a pump head stand 27, on which a pump head main shaft 30 that engages with a pump head bearing 29 on the other end of the multi-stage pump body 25 is fixed by a fastening bolt 31, and on the stand plate 36 A motor bracket 21 is fixedly installed in the middle, and a liquid supply system 35 with a multi-stage pump body 25 and a stepper motor 22 is fixedly installed on the motor bracket 21. Under the control of the main control computer 42, several liquid supply speeds with different concentrations are provided to several different poisoning chambers 5 of the poisoning system 47. A gas cylinder fixing frame 14 is fixedly installed on the left wall of the bracket vertical plate 36. The fixed gas source gas cylinder 15 and the air supply system 16 composed of the filter diverter 20 and the air flow controller 12 under the control of the main control computer 42 drive the atomizing nozzle 8 to atomize the poisoning agent 38 through the gas-liquid mixer 10 under the control of the main control computer 42. The bottom of the support frame 46 is a flat table plate 4 with an elastic foot pad 40. 4. On the right side of the upper surface of the table top plate 44, a poison bottle 39 containing a poison agent 38 is placed. The poison agent 38 is provided to the poison system 47 through a pipette 41 and a liquid supply system 35. A main control computer 42 is placed in the middle of the upper surface of the table top plate 44, which is connected to various control actuators through a control bus 43. On the left side of the upper surface of the table top plate 44, a cabin bracket 3 is fixedly installed by a bracket screw 45. A poison system 47 consisting of several poison cabins 5 with the same shape and size and a gas-liquid mixer 10 under the control of the main control computer 42 and a filter gas valve 1 under the control of the main control computer 42 is fixedly installed on the cabin bracket 3. The liquid supply system 35 and the gas supply system 16 support Under the control of the main control computer 42, a multi-concentration synchronous precise control poisoning experiment is carried out on the experimental animal 2 placed in the poisoning cabin 5; the main control computer 42 is composed of three parts: a computer hardware system dedicated to toxicology research, a special software program system for related majors of multi-concentration synchronous precise control poisoning experiments, and an execution system of various applied electrical components connected to the stepper motor 22, the airflow controller 12, the gas-liquid mixer 10 and the filter air valve 1 through a control bus 43. The computer hardware system and the special software program system are combined in the main control computer 42 and are connected to the stepper motor 22, the airflow controller 12, the gas-liquid mixer 10 and the filter air valve 1 in sequence through the control bus 43 of the execution system.The received parameters in each execution process of the experiment are sorted, analyzed, stored and recorded, and fed back to the main control computer 42 in time, and then the execution system of each application electrical component installed on the stepper motor 22, airflow controller 12, gas-liquid mixer 10 and filter air valve 1 is controlled in turn through the control bus 43 to feedback control these actuators to conduct accurate and synchronous poisoning experiments.

[0019] Example:

[0020] When in use, first prepare the experimental animal 2 and the poison agent 38 for the experiment, clean the poison agent bottle 39, pour the prepared poison agent 38 into the poison agent bottle 39, check whether the gas in the gas source cylinder 15 of the gas supply system 16 is sufficient, then power on the main control computer 42, set the speed of the stepper motor 22 in the special software program system for multi-concentration synchronous precise control of poisoning experiments, adjust the pressure reducing valve 17 and the flow meter 18 of the gas source cylinder 15 to the required pressure value, open the locked valve 48 in the middle of the poisoning cabin 5, put the prepared experimental animal 2 into the poisoning cabin 5 and then close the locked valve 48, everything is ready, The poisoning experiment is started in the dedicated software program system of the main control computer 42. The main control computer 42 controls the execution system of each application electrical component installed on the stepper motor 22, the airflow controller 12, the gas-liquid mixer 10 and the filter air valve 1 in sequence through the control bus 43; the stepper motor 22 in the liquid supply system 35 drives the multi-stage pump body 25 installed on the right side of the bracket stand 36 of the support stand 46 at a set precise speed under the control of the main control computer 42. All the pump heads of each stage rotate at the same angular velocity. The multi-stage pump body 25 is a plurality of individual pump bodies superimposed together and coaxially installed on the pump head main shaft 30. The pump head main shaft 30 at the other end of the multi-stage pump body 25 The pump head bearing 29 on the shaft 30 is engaged with the pump head bracket 27 and is fixed to the right side of the bracket vertical plate 36 of the support stand 46 by fastening bolts 31. As the pump head works stably, several pump heads with different radii of the multi-stage pump body 25 are stacked and coaxially installed on the same pump head main shaft 30 in sequence. Each pump head has a pump pipe gland 26 with the same circle as the outer circumference on the outer circumference. Below the pump pipe gland 26 is a disc-shaped roller wheel 37. The peristaltic rollers 24 are evenly distributed at equal distances around the outer circumference of the roller wheel 37. The roller wheel 37 drives the peristaltic rollers 24 to do circular motion under the drive of the pump head main shaft 30, and the roller wheel 37 also rotates freely at the same time, and the peristaltic rollers The peristaltic pump tube 32 installed on the multistage pump body 24 is squeezed and kneaded by the peristaltic roller 24 and the pump tube gland 26 to form a negative pressure to attract and drive the liquid in the peristaltic pump tube 32 to be transported, and the linear speed of the peristaltic roller 24 of each different pump head of the multistage pump body 25 on the circumference of the roller wheel 37 is the product of its angular velocity and radius, so the pump head with a larger radius has a greater rate of transporting liquid. Therefore, each peristaltic pump tube 32 of the multistage pump body 25 is driven by the multistage pump body 25 to transport the poisoning agent 38 in the poisoning agent bottle 39 through the suction tube 41 connected to the pump tube connector 33 at different rates to the respective gas-liquid mixers 10 through the pump tube connector 33 and the infusion tube 34 on the other side;After the gas in the gas source cylinder 15 in the gas supply system 16 is adjusted to the required pressure value by the pressure reducing valve 17 and the flow meter 18, the gas enters the filter diverter 20 through the main air pipe 19 for filtration and diversion, and then enters several air flow controllers 12 under the control of the main control computer 42 through the branch air pipe 13. The air flow adjusted according to the required flow rate of each poisoning cabin 5 is also transmitted to the gas-liquid mixer 10, so that the poisoning agent 38 of different rates provided by the multi-stage pump body 25 can be atomized into atomized aerosols 7 of different concentrations through the atomizing nozzle 8 to carry out a multi-concentration synchronous and precise control of the poisoning experiment on the experimental animal 2 in the poisoning cabin 5; the computer hardware system and the special software program system are combined in the main control computer 42 and connected to the stepping motor 22, the air flow controller 12, the gas-liquid mixer 10 and the filter air valve 1 in sequence through the control bus 43 of the execution system, and the various parameters received in each execution process of the experiment are sorted, analyzed, stored and recorded, and fed back to the main control computer 42 in time, and then controlled in sequence through the control bus 43 to drive the installed The execution system of each applied electrical component on the stepper motor 22, the airflow controller 12, the gas-liquid mixer 10 and the filter air valve 1 feedback controls these execution mechanisms to conduct accurate and synchronous poisoning experiments; after the experiment is completed, the stepper motor 22, the airflow controller 12, the gas-liquid mixer 10 are stopped in the special software program system related to the multi-concentration synchronous precise control of poisoning experiments, and the multi-stage pump body 25 also stops working, and the liquid supply system 35 no longer provides the poisoning agent 38 to the gas-liquid mixer 10 of the poisoning system 47; The pressure reducing valve 17 of the closed gas source cylinder 15 no longer provides gas to the gas-liquid mixer 10 of the poisoning system 47; the dedicated software program system controls the opening of the filter gas valve 1 under each poisoning chamber 5, and the waste gas generated during the experiment is discharged through the waste gas discharge pipe 50; after the waste gas discharge is completed, the power of the main control computer 42 is turned off, and then the locked valve 48 in the middle of the poisoning chamber 5 is opened, the experimental animal 2 that has completed the poisoning experiment is taken out and the locked valve 48 is closed, and the taken out experimental animal 2 is further tested and analyzed. ;

Claims

1. A multi-concentration synchronous precise control poisoning experimental device, characterized by: The invention comprises a support frame (46) with an elastic foot pad (40), on which a main control computer (42) and a liquid supply system (35), an air supply system (16) and a poisoning system (47) under its control are installed. The stepper motor (22) of the liquid supply system (35) drives a multi-stage pump body (25) to transport the poisoning agent (38) in the poisoning agent bottle (39) installed on the support frame (46) at different rates to the poisoning system (47) composed of a plurality of poisoning chambers (5) of the same shape and volume installed on the support frame (46). Each poisoning chamber (5) has a lockable valve (48) and a breathable partition (6) for containing experimental animals (2) in the middle. The lower part of each poisoning chamber (5) is sealed with a filter air valve (1) and an exhaust gas discharge pipe (50). The upper part of each poisoning chamber (5) is sealed with a mist filter. A spray nozzle (8) and a gas-liquid mixer (10), one end of each gas-liquid mixer (10) is connected to a filter diverter (20) and a gas source cylinder (15) of an air supply system (16) through a sealed air supply pipe (11) and an air flow controller (12), so as to provide a fresh, special gas source for high-pressure atomization to the poisoning chamber (5), and the other end of the gas-liquid mixer (10) is connected to a multi-stage pump body (25) of a liquid supply system (35) through a sealed liquid infusion pipe (34), so as to provide the poisoning chamber (5) with a poisoning agent (38) required for atomization of the poisoning agent through a liquid pipette (41) in a poisoning agent bottle (39), and to provide atomized aerosols (7) of different concentrations formed by the poisoning agent (38) at different rates under the control of a main control computer (42), so as to carry out a poisoning experiment with synchronous and precise control of multiple concentrations on experimental animals (2) in the poisoning chamber (5); The multi-stage pump body (25) is a device in which a plurality of individual pump bodies are stacked together and coaxially mounted on a pump head spindle (30) with the speed of the pump head decreasing in a certain proportion in sequence from a high-speed pump head to a low-speed pump head (28) at the lowest level. One end of the multi-stage pump body (25) is connected to a motor spindle (23) of a stepper motor (22) and is driven to rotate synchronously or stop by the stepper motor (22) under the control of a main control computer (42). The pump head spindle at the other end of the multi-stage pump body (25) is connected to a motor spindle (23) of a stepper motor (22). (30) is engaged with the pump head bearing (29) connected to the pump head bracket (27) and fixed to the right side of the bracket stand (36) of the support stand (46) by fastening bolts (31) for stable operation. Several pump heads with different radii of the multi-stage pump body (25) are coaxially mounted on the same pump head main shaft (30) in sequence. The outer circumference of each pump head is provided with a pump pipe gland (26) of the same circle as the outer circumference. Below the pump pipe gland (26) is a disc-shaped roller wheel (37 ), the outer circumference of the roller wheel (37) is evenly distributed with peristaltic rollers (24) at equal distances. The roller wheel (37) drives the peristaltic rollers (24) to make circular motion under the drive of the pump head main shaft (30), and the roller wheel (37) also rotates freely at the same time. The peristaltic rollers (24) are installed with a taut peristaltic pump tube (32). Under the squeeze and kneading of the peristaltic rollers (24) and the pump tube gland (26), a negative pressure is formed to attract and drive the liquid in the peristaltic pump tube (32) to be transported. When the stepper motor (22) drives the multi-stage pump body (25) to rotate under the precise speed control of the main control computer (42), the pump heads at all levels, whether high-speed or low-speed, rotate at the same angular velocity, and the linear velocity of the peristaltic roller (24) of each different pump head on the circumference of the roller wheel (37) is the product of its angular velocity and radius. Therefore, the larger the radius of the pump head, the greater the rate at which it delivers liquid, thereby achieving the purpose of synchronously and precisely controlling the delivery of poisonous drugs at multiple concentrations.

2. According to claim 1, a multi-concentration synchronous precise control poisoning experimental device is characterized by: The liquid supply system (35) is a special device for conducting a multi-concentration synchronous and precisely controlled poisoning experiment on experimental animals (2), wherein the stepper motor (22) is connected to the motor main shaft (23) under the control of the main control computer (42) to drive a multi-stage pump body (25), and the infusion tube (34) is connected to the peristaltic pump tube (32) and the pipette (41) through the pump tube joint (33) to transport the poisoning agent (38) in the poisoning agent bottle (39) to different poisoning chambers (5) in the poisoning system (47) at different rates. The stepper motor (22) is fixedly installed on the middle part of the support stand (36) of the support stand (46) by the motor bracket (21). The stepper motor (22) drives a multi-stage pump body (25) at a precise speed under the control of the main control computer (42). A multi-stage pump body (25) fixedly mounted on the right side of a support stand (36) of a support frame (46) through a pump head bracket (27) is started or stopped synchronously, and each peristaltic pump tube (32) of the multi-stage pump body (25) is driven by the multi-stage pump body (25) to transmit the poisoning agent (38) in a poisoning agent bottle (39) mounted on a table plate (44) of the support frame (46) through a pipette (41) connected to a pump tube connector (33) at different rates to a poisoning system (47) composed of a plurality of poisoning chambers (5) of the same shape and volume mounted on the support frame (46) to perform a multi-concentration synchronous and precisely controlled poisoning experiment under the control of a main control computer (42).

3. The multi-concentration synchronous precise control poisoning experimental device according to claim 1 is characterized by: The gas supply system (16) is composed of a special high-pressure resistant gas source cylinder (15), a filter diverter (20) and a plurality of gas flow controllers (12). The gas supply system (16) is connected to different contamination chambers (5) through a gas supply pipe (11) to provide a control device for a gas-liquid mixer (10) under the control of a main control computer (42) with a special gas source for high-pressure atomization. One end of a main input gas pipe (19) is connected to the gas source cylinder (15) and the other end is sealed to the filter diverter (20). The gas supply system (16) is made of a sealed rigid shell wrapped with a special uniform and dense multi-porous ceramic fiber and nano-adsorbent material double-layer gas supply diverter layer and a plurality of diverter outlets, which are used to filter any particulate matter and impurities in the gas and evenly distribute the special gas that can pass through to each output branch gas. The gas source cylinder (15) is fixedly mounted on the left side wall of the bracket vertical plate (36) through the cylinder fixing frame (14). After the gas in the gas source cylinder (15) is adjusted to a required pressure value by the pressure reducing valve (17) and the flow meter (18), the gas enters the filter diverter (20) through the main air pipe (19) for filtration and diversion, and then enters a plurality of air flow controllers (12) under the control of the main control computer (42) through the branch air pipe (13). The air flow adjusted according to the required flow rate of each poisoning cabin (5) is transmitted to the gas-liquid mixer (10) and the atomizing nozzle (8) under the control of the main control computer (42) to atomize the poisoning agent (38) into atomized aerosol (7) to carry out a multi-concentration synchronous and precise control poisoning experiment on the experimental animals (2) in different poisoning cabins (5).

4. The multi-concentration synchronous precise control poisoning experimental device according to claim 1 is characterized by: The poisoning system (47) is a poisoning experiment execution device composed of a plurality of poisoning cabins (5) of the same shape and volume mounted on a table top plate (44) of a support frame (46) through a cabin bracket (3). The poisoning cabin (5) is a cylindrical hollow cabin made of transparent, non-toxic, odorless, strong and corrosion-resistant material and has a lockable valve (48) in the middle. The lower part of the poisoning cabin (5) is sealed with a V-shaped lower plate (4), and a breathable partition (6) for holding experimental animals (2) is placed on the upper side of the V-shaped lower plate (4). The middle of the V-shaped lower plate (4) is sealed with a filter valve (1) and an exhaust gas discharge pipe (50) controlled by a main control computer (42) through a lower air outlet pipe (49). The upper part of the poisoning cabin (5) is sealed with a conical upper The cover (9) has a gas-liquid mixer (10) connected to an atomizing nozzle (8) and controlled by a main control computer (42) in the middle of the upper cover, one end of which is connected to a liquid infusion tube (34) provided by a liquid supply system (35), and the other end is connected to an air supply tube (11) of an air supply system (16), so that aerosol atomization is formed in the poisoning chamber (5). Each poisoning chamber (5) is connected to a peristaltic pump tube (32) in a different pump head of a multi-stage pump body (25) of the liquid supply system (35) through a liquid infusion tube (34) and a pump tube connector (33), so that atomized aerosols (7) of different concentrations formed by a poisoning agent (38) can be provided at different rates to conduct a poisoning experiment on experimental animals (2) in the poisoning chamber (5) with synchronous and precise control of multiple concentrations.

5. The multi-concentration synchronous precise control poisoning experimental device according to claim 1 is characterized by: The support stand (46) is a table-type stand made of a strong, corrosion-resistant, rigid material capable of supporting a plurality of functional components. The rear portion of the support stand (46) is vertically connected to a support stand plate (36) with a table top plate (44). A pump head support (27) is fixedly mounted on the right side wall of the support stand plate (36). A pump head main shaft (30) engaging a pump head bearing (29) at the other end of the multi-stage pump body (25) is fixedly mounted on the support stand plate (36) by means of a fastening bolt (31). A motor support (21) is fixedly mounted on the middle portion of the support stand plate (36). A pump head support (27) is fixedly mounted on the motor support (21). A liquid supply system (35) having a multi-stage pump body (25) and a stepper motor (22) provides liquid supply speeds of different concentrations to several different poisoning chambers (5) of the poisoning system (47) under the control of a main control computer (42). A gas cylinder fixing frame (14) is fixedly installed on the left side wall of the bracket stand (36). The fixed gas source gas cylinder (15) and the gas supply system (16) composed of a filter diverter (20) and an air flow controller (12) under the control of the main control computer (42) are driven by a gas-liquid mixer (10) under the control of the main control computer (42). The atomizing nozzle (8) atomizes the poisoning agent (38). The bottom of the support frame (46) is a flat table surface (44) with an elastic foot pad (40). A poisoning agent bottle (39) containing the poisoning agent (38) is placed on the right side of the upper surface of the table surface (44). The poisoning agent (38) is provided to the poisoning system (47) through a pipette (41) and a liquid supply system (35). A main control computer (42) is placed in the middle of the upper surface of the table surface (44) and is connected to various control execution devices through a control bus (43). ) is fixedly mounted on the left side of the upper surface of the apparatus by a bracket screw (45), and a plurality of poisoning chambers (5) of the same shape and size with a gas-liquid mixer (10) controlled by a main control computer (42) and a poisoning system (47) composed of a filter air valve (1) controlled by the main control computer (42) are fixedly mounted on the chamber bracket (3). With the support of a liquid supply system (35) and an air supply system (16), a multi-concentration synchronous precise control poisoning experiment is carried out on the experimental animals (2) placed in the poisoning chambers (5) under the control of the main control computer (42).

6. The multi-concentration synchronous precise control poisoning experimental device according to claim 1 is characterized by: The main control computer (42) is composed of three parts: a computer hardware system dedicated to toxicology research, a dedicated software program system for related majors of multi-concentration synchronous precise control of poisoning experiments, and an execution system of various applied electrical components connected to a stepper motor (22), an air flow controller (12), a gas-liquid mixer (10) and a filter air valve (1) through a control bus (43). The computer hardware system and the dedicated software program system are combined in the main control computer (42) and installed on a table top plate (44) of a support stand (46) through the control bus (43) of the execution system. 3) It is connected to the stepper motor (22), the airflow controller (12), the gas-liquid mixer (10) and the filter air valve (1) in sequence, and the various parameters received in each execution process of the experiment are sorted, analyzed, stored and recorded, and fed back to the main control computer (42) in time. Then, through the control bus (43), the execution system of each application electrical component installed on the stepper motor (22), the airflow controller (12), the gas-liquid mixer (10) and the filter air valve (1) is controlled in sequence to feedback control these actuators to carry out accurate and synchronous poisoning experiments.

Images