An antioxidant, anti-aging composition, its formulation and use

Abstract

The application provides an antioxidant and anti-aging composition, a preparation and application thereof. The composition is formed by reasonable compounding of NADH, sheep placenta polypeptide, ginseng polysaccharide, oligopeptide and coenzyme Q10. In the scheme, the bioavailability of NADH is significantly increased by compounding NADH with sheep placenta polypeptide, ginseng polysaccharide, oligopeptide and coenzyme Q10, and the compounding combination can significantly play a synergistic effect. The superoxide anion radical clearance rate can reach 98%, the ABTS radical clearance rate can reach 98%, the DPPH radical clearance rate can reach 96%, and the free radical clearance effect is significantly improved. The composition of the application realizes the synergistic effect of each component in the aspects of antioxidant and anti-aging, effectively improves the bioavailability of the antioxidant active component, the raw materials are reasonably matched, there is no side effect, and the composition is suitable for internal and external use, and has good application value in the development of antioxidant and anti-aging medical, health care and cosmetic products.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of biological medicine, and particularly relates to an anti-oxidation and anti-aging composition, a preparation thereof and application. BACKGROUND

[0002] Senility refers to the phenomenon that the physiological and psychological adaptability of the body to the environment is progressively reduced and gradually tends to death. Since various biological molecules in the system have a large number of active groups, they interact to chemically react to make the biological molecules slowly crosslink to tend to be stable in chemical activity. With the passage of time, the degree of crosslinking is continuously increased, the active groups of the biological molecules are continuously consumed and reduced, and the original molecular structure is gradually changed. The accumulation of these changes will make the biological tissues gradually appear the senility phenomenon. Anti-aging aims to prolong the high-quality life of human beings and improve the health and longevity. With the improvement of living standards, people have more urgent requirements for preventing and treating senility, prolonging life, and improving life vitality.

[0003] There are many theories of senility, and senility is the result of the joint action of endogenous factors and exogenous factors. At present, the mechanism of senility is attributed to two major problems of oxidative free radical damage and the decrease of NAD+ level. The free radical theory of senility is one of the theories that can guide the practice of anti-aging. Oxygen free radicals are the first killer of accelerated senility of the skin and the body, and anti-oxidation, that is, anti-oxidation free radicals, become an effective way to slow down aging. Free radicals widely exist in the human body and have strong oxidizing ability. Appropriate concentration of free radicals has important physiological functions and plays a beneficial physiological role. However, when the generation and clearance mechanism of free radicals in the cells of the body is out of balance, too many free radicals will attack and damage biological macromolecules in the body, such as DNA, protein, carbohydrate, nucleic acid, lipid and plasma membrane, and further cause diseases. Therefore, the supplementation of antioxidants is particularly important in modern human health life.

[0004] Many compound studies can be used for the anti-oxidation of the body. NADH is reduced nicotinamide adenine dinucleotide, which naturally exists in every cell and participates in thousands of reactions. In order to emphasize its importance to life activities, scientists named it "human coenzyme No. 1". NADH can be efficiently decomposed into NAD+ and hydrogen after entering the body, so as to increase the NAD+ level, and hydrogen is the most ideal substance that can efficiently scavenge free radicals. Because NADH can simultaneously solve the two most core problems related to senility, it is called "the king of anti-aging". Anti-oxidation peptides belong to one kind of bioactive peptides, which not only have the nutritional effect of polypeptide products, but also have the functions of anti-oxidation and free radical scavenging. However, NADH is expensive, has a large molecular weight and low bioavailability, and a large amount is usually recommended to ensure the drug effect, which is difficult to benefit the public.

[0005] Therefore, the research hotspot at present is to seek the use of multiple components to reduce the cost and improve the effect. For example, patent CN201810545670.X discloses an anti-aging composition compounded by NADH, ceramide, bird's nest acid, ginsenoside, icariin, baohuo glycoside I, s-adenosyl methionine, phosphatidylserine, NMN, PPD, etc. However, the anti-oxidation components are simply combined, and the problem of low bioavailability of NADH has not been well solved. SUMMARY

[0006] The present application aims at the problems of limited effect of single or compounded use of anti-oxidation and anti-aging substances and low bioavailability of active ingredients, and provides an anti-oxidation and anti-aging composition. After NADH is compounded with sheep placenta polypeptide, ginseng polysaccharide, oligopeptide and coenzyme Q10, the bioavailability of NADH is significantly increased, and the activity of the obtained composition in anti-oxidation and anti-aging is significantly enhanced. The composition of the present application can remove 98% of superoxide anion free radicals, 98% of ABTS free radicals and 96% of DPPH free radicals, effectively improve the bioavailability of each anti-oxidation active component, especially NADH, and synergistically promote each component to achieve good anti-aging effect.

[0007] The primary object of the present application is to provide an anti-oxidation and anti-aging composition.

[0008] Another object of the present application is to provide the use of the above-mentioned composition in the preparation of anti-oxidation and anti-aging drugs, health products or daily chemical products.

[0009] Another object of the present application is to provide a preparation prepared from the above-mentioned composition.

[0010] Another object of the present application is to provide a health product containing the above-mentioned composition.

[0011] Another object of the present application is to provide a skin care product containing the above-mentioned composition.

[0012] The above-mentioned object of the present application is realized by the following technical scheme:

[0013] The present application provides an anti-oxidation and anti-aging composition, which is composed of the following components: NADH, sheep placenta polypeptide, ginseng polysaccharide, oligopeptide and coenzyme Q10.

[0014] The anti-oxidation and anti-aging composition of the present application is summarized by scientific analysis of the synergistic compatibility of each anti-oxidation active component. Among them, nicotinamide adenine dinucleotide (NADH) is the only substance that can be used by NAD+ dependent adenosine diphosphate (ADP) ribose transferase as an essential coenzyme in the oxidation-reduction process, plays a role in transferring hydrogen in biological oxidation, activates the multi-enzyme system, promotes the synthesis and metabolism of nucleic acids, proteins and polysaccharides, improves material transport and regulation and control, and improves metabolism. NADH has clear composition, clear mechanism of action and high safety, has the functions of "promoting nutrient and energy metabolism + resisting deep oxidative damage + regulating immunity", and has high clinical application value.

[0015] However, as described above, NADH is expensive, has a large molecular weight and low bioavailability. Through a large number of exploration and research, the present application obtains a composition which can significantly improve the bioavailability of NADH and the synergistic effect of each component, i.e. the combination of NADH assisted by sheep placenta polypeptide, ginseng polysaccharide, oligopeptide and coenzyme Q10. Sheep placenta polypeptide is widely used in medical care, food, cosmetics and other fields, and as a small molecule antioxidant peptide, it has good scavenging effect on superoxide anion, hydroxyl radical, DPPH and ABTS+. The structure and pharmacological activity of ginseng polysaccharide are increasingly valued by people, and research reports that ginseng polysaccharide has complex structural characteristics and diverse biological activities, can enhance the immune function of the body, can be used as an auxiliary drug to prevent and treat tumors, can significantly inhibit liver damage caused by carbon tetrachloride and reduce blood sugar; at the same time, it can effectively improve the content of antioxidant enzymes in the body, help to improve the body's ability to defend against free radicals, help to scavenge free radicals and enhance the body's antioxidant capacity. Oligopeptide is a chemically synthesized NADH energy synthesis regulation active peptide, which can enhance the biological effect of NADH. Coenzyme Q10 is a fat-soluble antioxidant and an important element indispensable to human life, which can activate human cells and cell energy nutrients, has the functions of improving human immunity, enhancing antioxidant, delaying aging and enhancing human vitality, and is widely used in the treatment of cardiovascular system diseases in medicine.

[0016] Our experimental results show that in the composition of the present application, the bioavailability of NADH is significantly improved after being combined with sheep placenta polypeptide, ginseng polysaccharide, oligopeptide and coenzyme Q10, and the overall scavenging effect of the combined composition on free radicals is significantly improved, and each active component has synergistic effect in anti-oxidation and anti-aging.

[0017] Preferably, the mass fraction of each component in the composition of the present application is: NADH 40-70 parts, sheep placenta polypeptide 5-12 parts, ginseng polysaccharide 5-12 parts, oligopeptide 8-20 parts, and coenzyme Q10 10-22 parts.

[0018] Further preferably, the mass fraction of each component is: NADH 40-60 parts, sheep placenta polypeptide 8-10 parts, ginseng polysaccharide 8-10 parts, oligopeptide 10-15 parts, coenzyme Q10 15-20 parts.

[0019] As a most preferred embodiment, the mass fraction of each component is: NADH 50 parts, sheep placenta polypeptide 10 parts, ginseng polysaccharide 10 parts, oligopeptide 10 parts, coenzyme Q10 20 parts.

[0020] The application also claims the use of the above-mentioned composition in the preparation of anti-oxidation and anti-aging drugs, health products or daily chemical products.

[0021] The application also claims the preparation of a preparation prepared from the above-mentioned composition, which is a different dosage form prepared by adding a pharmaceutically acceptable excipient to the anti-oxidation and anti-aging composition.

[0022] Preferably, the dosage form is a powder, granules, capsules, tablets, powder, solution, emulsion or suspension.

[0023] Preferably, the oligopeptide includes oligopeptide-1, oligopeptide-3, oligopeptide-5, oligopeptide-6.

[0024] The above-mentioned composition of the application is both food and medicine, so it can be used in food and daily chemical products, and can be taken internally and externally, achieving the purpose of treating both the symptoms and the root cause in terms of anti-oxidation and anti-aging.

[0025] Therefore, the application also claims an anti-oxidation and anti-aging health product containing the above-mentioned composition, which is prepared by adding a pharmaceutically acceptable excipient to the anti-oxidation and anti-aging composition. The health product can be oral liquid, capsules, granules, tablets, soft capsules, granules, instant powder, etc.

[0026] The anti-oxidation and anti-aging composition of the application is not strictly limited in terms of frequency and dosage of administration. Generally, the anti-oxidation and anti-aging composition of the application can be administered once or more per day. As a preferred embodiment, the anti-oxidation and anti-aging composition of the application is taken in an amount of 100-5000 mg per day, taken 1-2 times a day.

[0027] In addition, the application also claims an anti-oxidation and anti-aging skin care product containing the above-mentioned composition, which is prepared by adding an acceptable matrix in skin care products to the anti-oxidation and anti-aging composition. The skin care product can be a mask, eye cream, face cream, essence, emulsion, facial cleanser, toner, sunscreen product, etc.

[0028] Compared with the prior art, the application has the following beneficial effects:

[0029] The application remarkably increases the bioavailability of NADH by compounding NADH with sheep placenta polypeptide, ginseng polysaccharide, oligopeptide and coenzyme Q10, and remarkably improves the effect of the obtained composition on free radical scavenging, and the comprehensive antioxidant capacity is completely different. The composition of the application has a free radical scavenging rate of 98% for superoxide anion, 98% for ABTS and 96% for DPPH, realizes the synergistic effect of the components in terms of antioxidant and anti-aging, effectively improves the bioavailability of NADH, has no side effect, is suitable for internal and external use, and has good application value in the development of antioxidant and anti-aging medical, health care and cosmetic products. DETAILED DESCRIPTION

[0030] The application will be further described below in combination with specific examples, but the examples do not limit the application in any form. Unless otherwise specified, the reagents, methods and devices used in the application are conventional reagents, methods and devices in the technical field.

[0031] Unless otherwise specified, the reagents and materials used in the following examples are commercially available.

[0032] Example 1: Antioxidant and Anti-aging Composition

[0033] 1. The dosage and ratio of each antioxidant and anti-aging composition are shown in Table 1.

[0034] Table 1

[0035]

[0036] In the composition 1 and 5, the oligopeptide is oligopeptide-1, in the composition 2 and 6, the oligopeptide is oligopeptide-3, in the composition 3, the oligopeptide is oligopeptide-5, and in the composition 4, the oligopeptide is oligopeptide-6.

[0037] Example 2: Acute Toxicity Test of Each Composition

[0038] (1) Experimental method

[0039] Thirty-five clean Kunming mice were taken, half male and half female, 5 in each group. The drug group was given 1.0 g / mL of each composition in Table 1 within 24 h, 0.4 mL each time, 6 h apart, and the total amount of drug was 1.2 g / d. The blank control group was given the same volume of normal saline. The mice were fasted but not watered 12 h before administration and during administration, and were normally fed 4 h after the last administration. The body weight of the mice was measured every day, and the observation lasted for 7 days.

[0040] (2) Experimental results

[0041] The mice were in good mental state, with bright fur, normal water intake and food intake after 3 times of gavage of the anti-oxidation and anti-aging composition within 24 hours. The body weight of the mice before and after administration had no statistical difference with the control group, indicating that the anti-oxidation and anti-aging composition had no acute toxicity to the mice. Details are shown in Table 2.

[0042] Table 2

[0043] Mouse weight Before administration (g) 7th day after administration (g) Group 1 20.52±1.34 26.48±1.54 Group 2 22.4±0.51 27.12±1.89 Group 3 21.34±1.79 25.84±1.22 Group 4 21.54±1.32 26.44±1.3 Group 5 21.06±1.51 26.9±0.98 Group 6 21.36±0.8 26.28±1.71 Control group 20.26±1.32 25.38±1.55

[0044] Long-term toxicity test of each group formula in Example 3

[0045] (1) Experimental method

[0046] Forty Wistar rats with a body weight of (126.75 ± 4.07) g, half male and half female, were divided into high, medium and low three dose concentrations (1.0, 0.5, 0.25 g / mL) administration groups and one control group, 10 rats in each group. The administration group was given the formula 2, and the administration amount was 2 mL, once a day, and the gavage was continuously administered for 30 days. During the whole test period, the general behavior and death of the rats were observed and recorded every day, and the body weight of the rats was measured once a week. After 30 days, the animal body weight, hematology and serum biochemical indexes, and organ weight were detected to comprehensively evaluate the toxicity of the drug.

[0047] (2) Experimental results

[0048] The results are shown in Table 3. After 30 days of administration, there was no significant difference in the body weight, hematology indexes (white blood cells, red blood cells, platelets) of the rats in the administration group and the control group. After the rats were sacrificed after 30 days, no obvious organ lesions were found during dissection, and there was no obvious difference in the organ coefficients of each group. After 30 days of administration, there was no significant difference in the blood biochemical indexes (glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, urea, creatinine) of the rats in each group, indicating that long-term medication was safe.

[0049] Table 3

[0050] Low-dose group (n=10) Medium-dose group (n=10) High-dose group (n=10) Control group (n=10) Before administration (g) 125.81±2.56 126.82±5.34 126.05±3.9 128.32±4.14 7th day (g) 193.53±6.59 196.27±6.28 190.22±4.55 192.26±6.76 14th day (g) 242.65±7.48 246.01±6.25 240.91±8.73 247.39±6.47 21st day (g) 300.22±11.46 293.49±10.16 292.99±11.71 293.88±10.24 30th day (g) 345.18±18.46 355.49±10.04 339.65±12.18 342.87±18.12 Leukocytes (xlO 9 / L) 4.55±0.68 4.75±0.77 4.21±0.61 4.44±0.34 Red blood cells (xlO 12 / L) 8.53±0.09 8.5±0.12 8.51±0.09 8.58±0.13 Platelets (xlO 9 / L) 793.28±39.52 791.07±40.08 800.15±44.61 787.13±41.28 Alanine aminotransferase (U / L) 47.36±4.53 47.18±4.94 50.79±6.14 48.25±4.8 Aspartate aminotransferase (U / L) 141.17±7.96 134.14±10.68 136.3±9.92 137.99±11.68 Urea (mmol / L) 6.99±0.37 7.15±0.34 7.19±0.29 7.07±0.40 Creatinine (μmol / L) 40.48±9.22 43.08±9.89 48.72±8.92 42.79±9.09 Heart coefficient (%) 0.36±0.01 0.37±0.01 0.36±0.01 0.37±0.02 Liver coefficient (%) 3.53±0.17 3.47±0.25 3.44±0.22 3.34±0.15 Kidney coefficient (%) 0.56±0.09 0.59±0.69 0.55±0.08 0.57±0.07

[0051] Anti-oxidation performance test of Example 4

[0052] SOD is a key enzyme for removing oxygen free radicals in the body, and GSH-Px is an enzyme for catalyzing the decomposition of peroxide in the body. The activity thereof can reflect the antioxidant capacity of the tissue, and is an important index for evaluating the aging of the body. MDA is a peroxidation product of lipid, and is closely related to the generation of free radicals in the body and the degree of lipid peroxidation of the tissue cells of the body. It can reflect the damage state of the oxidative stress of the tissue of the body, and is also one of the important indexes for evaluating the aging.

[0053] (1) Modeling, administration and experimental grouping

[0054] Modeling: 60 Wistar rats with a body weight of (126.21±2.61) g, half male and half female, were randomly divided into 6 groups, 10 rats in each group. Except for the blank control group, the rest of the rats were injected subcutaneously with 5% D-galactose 120 mg / kg per day to establish the aging model.

[0055] Drug administration: The rats were continuously administered intragastrically for 30 days from the 13th day of modeling, and the administration volume of each group was 2 mL. After each administration, the rats were fasted for 24 hours without water restriction, and blood was taken from the eye fundus. After the blood was completely coagulated at room temperature, it was centrifuged to separate the serum for use. Subsequently, the rats were sacrificed by dislocation, and the liver and brain tissues were quickly separated, washed with sodium chloride solution, and prepared into 10% tissue homogenate. The SOD activity, GSH-Px activity and MDA content of the serum, liver and brain tissue were determined by xanthine oxidase method, dithiothreitol method and barbituric acid spectrophotometry, respectively.

[0056] Test grouping: ① The drug group of the present application: the composition of group 2 was added to physiological saline to prepare a solution with a concentration of 0.5 g / mL; ② Comparative group 1: NADH+ sheep placenta polypeptide (the same composition ratio as group 2, concentration 0.5 g / mL); ③ Comparative group 2: ginseng polysaccharide+oligopeptide-3+coenzyme Q10 (the same composition ratio as group 2, concentration 0.5 g / mL); ④ Comparative group 3: the same composition as group 2, except that ginseng polysaccharide is replaced by American ginseng polysaccharide; ⑤ Model control group: physiological saline, ⑥ Blank control group: physiological saline.

[0057] (2) Experimental results

[0058] As shown in Table 4, the serum SOD activity, GSH-Px activity and MDA content of the drug group of the present application had no statistical difference with the blank control group, indicating that the present application can effectively enhance the body's antioxidant free radical scavenging ability and reduce the degree of tissue cell damage, and the indicators can basically recover to the level before the aging modeling.

[0059] It was also found that the SOD activity and GSH-Px activity of comparative group 1, comparative group 2 and comparative group 3 were lower than those of the drug group of the present application (P<0.05), and the MDA content was higher than that of the present application (P<0.05), indicating that the antioxidant and anti-aging effects of the above three groups were not as good as those of the drug group of the present application, indicating that the combination of the present application is the best, and replacing one of the components will reduce the antioxidant and anti-aging efficiency.

[0060] Table 4

[0061]

[0062] Comparative example

[0063] In order to verify that the antioxidant and anti-aging performance of the application is best at a specific dosage and component, further comparative experiments are carried out to verify the dosage and ratio of components of each antioxidant and anti-aging composition in comparative groups 4-10, as shown in Table 5.

[0064] Table 5

[0065]

[0066] Comparison of free radical scavenging ability of experimental groups and comparative groups in Example 5

[0067] (1) The six groups in Example 1 and the group formulas of comparative groups 4-10 are respectively added with 50% ethanol to prepare a solution with a concentration of 0.5 g / mL, and superoxide anion radical scavenging, ABTS radical scavenging and DPPH radical scavenging test experiments are carried out.

[0068] (2) Experimental results

[0069] As can be seen from the results in Table 6, the composition of the application has a superoxide anion radical scavenging rate of up to 97%, an ABTS radical scavenging rate of up to 97%, and a DPPH radical scavenging rate of up to 96%. Compared with the group formulas obtained by the comparative group experiments, the application produces a synergistic health care effect by reasonably compounding the components, so that different components produce a mutual promoting effect, especially the activity in antioxidant and anti-aging is significantly enhanced, and the bioavailability of each antioxidant active component can be effectively improved. It can be seen that the composition of the application has good free radical scavenging activity, and the effect is significantly better than that of the positive control group.

[0070] Table 6 Free radical scavenging rate

[0071]

[0072] Example 6 An antioxidant and anti-aging capsule

[0073] (1) Preparation method of the capsule

[0074] In this embodiment, the dosage of the main components contained in the capsule is as follows: ① Experimental group: the complex formula of NADH, sheep placenta polypeptide, ginseng polysaccharide, oligopeptide and coenzyme Q10 is weighed and taken according to the weight ratio of group formula 2, ② Control group: the complex formula is weighed and taken according to the weight ratio of comparative group 4. Then the compound composition is crushed and mixed uniformly, granulated through an 18-mesh sieve, dried, and granules are prepared. The obtained granules are filled into DRcaps acid-resistant capsules to obtain antioxidant and anti-aging capsules. The total dosage of the complex formula contained in each capsule is 1 g.

[0075] (2) Capsule administration experiment

[0076] 60 subjects are selected and randomly divided into two groups, 30 people in each group, and capsules prepared from the prescription 2 and the comparative group 4 are taken respectively for three months, once a morning, two capsules each time, and 100-200 mL of warm boiled water is taken. Before and after the test, the sleep quality, memory, immunity, face color, face skin, hair loss, appetite and other 7 aspects of each group of subjects are evaluated, 1 point means the feeling is not obvious, and 5 points means the feeling is obvious.

[0077] 5ml of peripheral blood of the subject is taken, centrifuged at 10000g for 5 minutes. 20ul of supernatant is taken and added to a 96-well plate, 3-5 repeated holes are set in each group, the NADH ELISA kit is used to draw a standard curve, and the NADH content of the serum sample is calculated according to the standard curve to detect the bioavailability of NADH.

[0078] The results are shown in Table 7. The results show that the subjects in the test group are obviously better than the control group in each physiological evaluation item, and the NADH content in the blood is obviously higher than that in the control group, and the difference is statistically significant (P<0.05). It shows that the specific formula of the composition of the application can improve the bioavailability of NADH, improve the body's sleep, memory, immunity and other skills, and also reflects that the anti-aging preparation of the application has excellent anti-aging effect.

[0079] Table 7

[0080]

[0081] Example 7 An antioxidant and anti-aging leave-on mask

[0082] (1) The formula of the antioxidant leave-on mask is shown in Table 8:

[0083] Table 8

[0084]

[0085]

[0086] (2) The preparation method of the leave-on mask is as follows:

[0087] S1. Homogenize 70℃ ionized water with a homogenizer at high speed, add carbomer 940 and methyl cellulose, homogenize for 6min, then add laurylamine to fully dissolve carbomer 940 and methyl cellulose into transparent state, cool and reserve;

[0088] S2. At room temperature, add glycerol, squalane and antioxidant composition into deionized water respectively, and stir uniformly;

[0089] S3. Mix the products obtained in the above two steps, fully stir, then add octanoyl hydroxamic acid, and supplement with deionized water to 100%, fully dissolve and stand.

[0090] (1) Efficacy evaluation of the leave-on mask

[0091] The leave-on mask was subjected to superoxide anion radical scavenging, ABTS radical scavenging and DPPH radical scavenging test experiments in the manner of Example 5, and the results showed that the leave-on mask of the present example had a superoxide anion radical scavenging rate of 92%, an ABTS radical scavenging rate of 91%, and a DPPH radical scavenging rate of 93%. This indicated that the leave-on mask prepared by adding the antioxidant and anti-aging composition of the present application had good radical scavenging efficacy.

[0092] Twenty 30-35 year old test subjects were recruited to test the leave-on mask, and the results showed that 70% of the test subjects considered that the mask had high moisturizing degree, good moisturizing effect, strong smoothness, no greasiness, no skin stinging during application, and no irritation to the eyes. After one week of continuous use, the subjects felt that the facial skin was obviously tightened, elastic and wrinkle-reduced. This indicated that the leave-on mask prepared by adding the antioxidant and anti-aging composition of the present application had significant anti-aging effect.

[0093] The above examples are preferred embodiments of the present application, but the embodiments of the present application are not limited by the above examples, and any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present application shall be equivalent replacement methods, and all shall be included in the protection scope of the present application.

Claims

1. An antioxidant, anti-aging composition characterized in that, The mass fraction of each component is: NADH 50 parts, sheep placenta polypeptide 10 parts, ginseng polysaccharide 10 parts, oligopeptide 10 parts, coenzyme Q10 20 parts; the oligopeptide is oligopeptide-3.

2. Use of the composition of claim 1 in the preparation of antioxidant, anti-aging medicine, health care products or daily chemical products.

3. A formulation prepared from the composition of claim 1, wherein, The preparation is different dosage forms prepared by adding excipients to the composition.

4. The preparation according to claim 3, characterized in that, The dosage form is powder, granules, capsules, tablets, powder, solution, emulsion or suspension.

5. An antioxidant, anti-aging health care product, characterized by, The health care product is prepared by adding pharmaceutically acceptable excipients to the composition of claim 1.

6. An antioxidant, anti-aging skin care product, characterized in that, The skin care product is prepared by adding acceptable bases in skin care products to the composition of claim 1.

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