In vitro diagnostic analysis systems and optical detection devices

Abstract

The present invention discloses an in vitro diagnostic analysis system and an optical detection device. The optical detection device includes a lens module, a light source module, a detection module and a driver. The lens module includes a first mounting unit, a dichroic mirror, an excitation plate and an emission plate. The dichroic mirror and the excitation plate are arranged at intervals in the first mounting unit and cooperate with the excitation plate to form an excitation light path. The dichroic mirror and the emission plate are arranged at intervals in the first mounting unit and cooperate with the emission plate to form an emission light path. The light source module includes a second mounting unit and a light-emitting element. The light-emitting element is arranged on the second mounting unit and the light-emitting element is arranged at intervals from the excitation plate. The detection module includes a third mounting unit and a detection element. The detection element is arranged on the third mounting unit and the detection element is arranged at intervals from the emission plate. The driver is used to drive the first mounting unit to move. The optical detection device has a more compact layout. The in vitro diagnostic analysis system uses the optical detection device, which is conducive to reducing the volume.

Description

Technical Field

[0001] The present invention relates to the technical field of in vitro diagnosis, and in particular to an in vitro diagnosis analysis system and an optical detection device. Background Art

[0002] Polymerase Chain Reaction (PCR) is a molecular biology technique used to amplify specific DNA fragments. Real-time quantitative polymerase chain reaction (qPCR) is a method that adds corresponding fluorescent dyes or fluorescent labeled probes to conventional PCR, and detects the entire PCR process in real time through changes in fluorescent signals during the PCR reaction. It uses fluorescent chemicals to monitor the total amount of products after each PCR cycle, and quantitatively analyzes specific DNA sequences in the sample to be tested. Fluorescence quantitative PCR instrument is a reaction instrument that uses qPCR technology for real-time detection, and is generally guaranteed by a thermal cycle system and a fluorescence real-time detection system.

[0003] At present, the qPCR technology for in vitro diagnosis usually requires the detection of multiple indicators (multiple target detection objects) for one or more samples in one test. Traditional optical detection devices use multiple independent optical units to detect multiple target detection objects in the same reaction chamber or to detect the same or different targets in multiple reaction chambers. During the detection process, it is often necessary to change the relative position of the optical unit and the PCR chamber by rotation or translation to complete the detection. After each rotation or translation operation, a reset step is often required to solve the problem of winding. This will lead to a complicated detection process, cumbersome steps, long detection time and excessively large overall size of the optical detection device, which is not conducive to the miniaturization of in vitro diagnostic analysis systems. Summary of the invention

[0004] Based on this, it is necessary to provide an in vitro diagnostic analysis system and an optical detection device. The optical detection device does not have the independent optical unit mentioned above, but includes a relatively independent lens module, a light source module and a detection module, each module can move independently, so that the winding problem can be avoided, the layout is more compact, the detection time is shortened, and it can also better meet the needs of miniaturization development of in vitro diagnostic analysis systems.

[0005] The technical solution is as follows:

[0006] On the one hand, the present application provides an optical detection device, including a lens module, a light source module, a detection module and a driver, the lens module includes a first mounting unit, a dichroic mirror, an excitation plate and an emission plate, the dichroic mirror and the excitation plate are arranged at intervals on the first mounting unit, and cooperate with the excitation plate to form an excitation light path, the dichroic mirror and the emission plate are arranged at intervals on the first mounting unit, and cooperate with the emission plate to form an emission light path; the light source module includes a second mounting unit, and at least two light-emitting components, each of which is arranged on the second mounting unit with an interval, and each of the light-emitting components is arranged at an interval from the excitation plate; the detection module includes a third mounting unit, and at least two detection elements, each of which is arranged on the third mounting unit with an interval, and each of the detection elements is arranged at an interval from the emission plate; the driver is used to drive the first mounting unit, to drive the first mounting unit and the second mounting unit, or to drive at least one of the first mounting unit and the third mounting unit to move.

[0007] The optical detection device is assembled by using relatively independent lens modules, light source modules and detection modules to cooperate with each other. In this process, each structure is modularly designed and produced and assembled, and then modularly assembled, so that the circuit layout between the optical detection device is more reasonable and the modules are more compact. When in use, it is only necessary to use the driver to rotate or move the first installation unit, the driver to rotate or move the first installation unit and the second installation unit, or the driver to rotate or move at least one of the first installation unit and the third installation unit, so that the excitation light path and the emission light path can be selectively docked with the light-emitting component and the detection element to achieve the detection of different types of target detection objects of the target sample. In this process, the light source module and the detection element do not need to be rotated, and there will be no winding problem. Therefore, there is no need to set up a winding avoidance space, so that the volume of the optical detection device can be smaller. The optical detection device is modularly designed to make the layout of the internal modules more compact, and the lens module can be driven to move independently, which can avoid the winding problem. The design is more flexible and can adapt to the miniaturization development needs of the in vitro diagnostic analysis system.

[0008] The technical solution is further described below:

[0009] In one embodiment, the light-emitting components are spaced apart along the same circle, the detection elements are spaced apart along another circle, and the driver is used to drive the first mounting unit to rotate along the center of the same circle; or the light-emitting components are spaced apart along a straight line, the detection elements are spaced apart along another straight line, and the driver is used to drive the first mounting unit to reciprocate along the straight line.

[0010] In one embodiment, the optical detection device further includes a first lens, which is disposed between the excitation plate and the light-emitting element; or / and the optical detection device further includes a second lens, which is disposed between the emission plate and the detection element.

[0011] In one embodiment, the first mounting unit is provided with an optical path channel, the optical path channel includes a first channel, a second channel and a common channel, the first channel is staggered with the second channel, and one end of the first channel and one end of the second channel are connected with one end of the common channel to form a common cavity; the lens modules correspond one-to-one to the optical path channels, the dichroic mirror is arranged in the common cavity, the excitation plate is arranged in the first channel, and forms an excitation light path with the dichroic mirror, and the emission plate is arranged in the second channel, and forms an emission light path with the dichroic mirror.

[0012] In one embodiment, the first mounting unit includes a light shield, a first plate and a second plate. The light shield is provided with an optical path channel. At least two light shields are sandwiched between the first plate and the second plate. The first plate is arranged above the light shield. The first plate is provided with a first through hole communicating with the second channel. The second plate is provided with a second through hole communicating with the common channel.

[0013] In one embodiment, there are at least two light path channels, and the light shields correspond to the light path channels one by one.

[0014] In one embodiment, at least two light shields are sandwiched between the first plate and the second plate along the same circumference to form a set of mounting modules, and the first mounting unit includes one or more sets of mounting modules.

[0015] In one of the embodiments, the first installation unit includes at least two groups of installation modules that are vertically stacked.

[0016] In one embodiment, the lens assembly also includes a first refractive element, which is arranged in the first channel and is arranged between the excitation plate and the dichroic mirror or between the excitation plate and the first lens; or / and the lens assembly also includes a second refractive element, which is arranged in the second channel and is arranged between the emission plate and the dichroic mirror or between the emission plate and the second lens.

[0017] In one embodiment, the optical detection device further includes a third lens, and the third lens is disposed between the dichroic mirror and the sample disk.

[0018] In one embodiment, the optical detection device further includes an integrated component, the third lens is fixed in the integrated component, and the integrated component is fixed between the first mounting unit and the sample tray.

[0019] On the other hand, the present application also provides an in vitro diagnostic analysis system, comprising the optical detection device in any of the above embodiments.

[0020] The in vitro diagnostic analysis system uses the optical detection device, which can independently drive the lens module, the light source module or the detection module to move, and has a more compact structure, which is conducive to reducing the volume. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 is a schematic structural diagram of an optical detection device in an embodiment;

[0022] Figure 2 is a schematic structural diagram of an optical detection device in an embodiment;

[0023] Figure 3 for Figure 2 Schematic diagram of the optical path channel shown;

[0024] Figure 4 for Figure 2 An exploded schematic diagram of a portion of the structure of the optical detection device shown;

[0025] Figure 5 for Figure 4 The structural schematic diagram of the lens module shown;

[0026] Figure 6 for Figure 5 An exploded schematic diagram of a local structure of a lens module is shown;

[0027] Figure 7 Schematic diagram of the PCR chip to be tested.

[0028] Description of reference numerals:

[0029] 10. Lens module; 100. First mounting unit; 110. Optical path channel; 112. First channel; 114. Second channel; 116. Common channel; 118. Common cavity; 120. Light shield; 130. First plate; 132. First through hole; 140. Second plate; 142. Second through hole; 200. Dichroic mirror; 300. Excitation plate; 400. Emission plate; 20. Light source module; 22. Second mounting unit; 24. Light emitting element; 26. First lens; 30. Detection module; 32. Third mounting unit; 34. Detection element; 36. Second lens; 40. Integrated component; 42. Third lens; 50. Sample tray; 52. Sample cavity. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods. It should be understood that the specific implementation methods described herein are only used to explain the present invention and do not limit the scope of protection of the present invention.

[0031] It should be noted that when an element is referred to as being "fixed on", "disposed on", "fixed on" or "installed on" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected" to another element, it may be directly connected to the other element or there may be a central element at the same time. Further, when an element is considered to be "fixed transmission connected" to another element, the two may be fixed in a detachable connection manner or in a non-detachable connection, as long as power transmission can be achieved, such as socketing, snap-on, one-piece fixation, welding, etc., which can be achieved in the prior art and will not be repeated here. When an element is perpendicular or approximately perpendicular to another element, it means that the ideal state of the two is vertical, but due to the influence of manufacturing and assembly, there may be a certain vertical error. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only and do not represent the only implementation method.

[0032] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0033] The “first” and “second” involved in the present invention do not represent specific quantities and orders, but are merely used to distinguish names.

[0034] At present, qPCR technology for in vitro diagnosis usually requires the detection of multiple indicators (multiple target detection objects) for one or more samples in one test. Traditional optical detection devices use multiple independent optical units to detect multiple target detection objects in the same reaction chamber or to detect the same target object in multiple reaction chambers.

[0035] Traditional optical detection devices use multiple independent optical units, and during the detection process, it is necessary to use rotation or translation to change the relative position of the optical unit or PCR chamber to achieve multiple detections. In addition, a reset step is often required after each rotation or translation operation to solve the problem of winding or repeated detection, which makes the control complicated, the steps cumbersome, and the detection time too long.

[0036] In addition, if the optical system and the reaction chamber are to be kept relatively still, it is necessary to use the same number of optical detection modules as the reaction chambers, and each optical module is required to detect multiple different types of target detection objects at the same time, which will make the detection module too large. In addition, the design and layout of the detection cavity on the card box are also limited by the space of the optical system, resulting in complex optical design.

[0037] Based on this, it is necessary to provide an optical detection device with a more compact layout that can adapt to the needs of miniaturization development of in vitro diagnostic analysis systems.

[0038] like Figure 1 to Figure 2 As shown, in one embodiment, an optical detection device is provided, including an independently arranged detection module 30 and a light source module 20, a lens module 10 capable of moving independently, and a driver (not shown) for driving the lens module 10 to move.

[0039] like Figure 2 and Figure 3 As shown, the lens module 10 includes a first mounting unit 100, a dichroic mirror 200, an excitation plate 300 and an emission plate 400. The dichroic mirror 200 and the excitation plate 300 are spaced apart on the first mounting unit 100 and cooperate with the excitation plate 300 to form an excitation light path. The dichroic mirror 200 and the emission plate 400 are spaced apart on the first mounting unit 100 and cooperate with the emission plate 400 to form an emission light path. The light source module 20 includes a second mounting unit 22 and at least two light-emitting components 24, each light-emitting component 24 is spaced apart from the other. It is placed on the second mounting unit 22, and each light-emitting component 24 is spaced apart from the excitation plate 300; the detection module 30 includes a third mounting unit 32, and at least two detection elements 34, each detection element 34 is spaced apart on the third mounting unit 32, and each detection element 34 is spaced apart from the emission plate 400; the driver is used to drive the first mounting unit 100, to drive the first mounting unit 100 and the second mounting unit 22, or to drive at least one of the first mounting unit 100 and the third mounting unit 32 to move.

[0040] like Figure 2 and Figure 3 As shown, the optical detection device is assembled by using relatively independent lens modules 10, light source modules 20 and detection modules 30 to cooperate with each other. In this process, each structure is modularly designed and produced and assembled, and then modularly assembled, so that the circuit layout between the optical detection device is more reasonable and the modules are more compact. When in use, it is only necessary to use a driver to rotate or move the first mounting unit 100, to drive the first mounting unit 100 and the second mounting unit 22, or to drive the first mounting unit 100 and the third mounting unit 32. At least one of the can realize that the excitation light path and the emission light path can be selectively docked with the light-emitting element 24 and the detection element 34, so as to realize the detection of different types of target detection objects of the target sample. The optical detection device is modularly designed to make the layout of the internal modules more compact, and can drive the lens module 10, the light source module 20 or the detection module 30 to move separately, which can meet the needs of the miniaturization development of the in vitro diagnostic analysis system.

[0041] Specifically, by using the device, the second mounting unit 22 can be kept stationary, that is, the light source module 20 can be kept stationary, and other components can be integrated and rotated together, that is, the lens module 10 and the detection module 30 can move together with the driver to achieve relevant detection. In this process, the light source module 20 is stationary, which can reduce the problem of winding.

[0042] Or, by using the present device, the third mounting unit 32 can be kept stationary, that is, the detection module 30 can be kept stationary, and other components can be integrated and rotated together, that is, the lens module 10 and the light source module 20 can move together with the driver to achieve relevant detection. In this process, the detection module 30 is stationary, which can reduce the problem of winding wires;

[0043] Alternatively, the device can be used to keep the second mounting unit 22 and the third mounting unit 32 stationary, that is, the light source module 20 and the detection module 30 are both stationary, and the other components are integrated together to rotate, that is, the lens module 10 moves with the drive to achieve relevant detection. In this process, the light source module 20 and the detection module 30 are stationary, that is, there will be no winding problem.

[0044] It should be noted that, in the context of the present invention, any type of device capable of emitting a monochromatic or broadband electromagnetic field will be understood to be included in the term "light emitting element 24". In addition, an array of multiple light emitting elements 24 having equal or different characteristics with respect to frequency, polarization, flux, electrical input power, or technology for emitting photons will also be included in the term "light emitting element 24". For example, light emitting diodes (LEDs), organic light emitting diodes (OLEDs), polymer light emitting diodes (PLEDs), quantum dot-based light emitting elements 24, white light emitting elements 24, halogen lamps, lasers, solid-state lasers, laser diodes, micro wire lasers, diode solid-state lasers, vertical cavity surface emitting lasers, phosphor-coated LEDs, thin-film electroluminescent devices, phosphorescent OLEDs, inorganic / organic LEDs, LEDs using quantum dot technology, LED arrays, floodlight systems using LEDs, white LEDs, incandescent lamps, arc lamps, gas lamps, and fluorescent lamps will be included in the term "light emitting element 24".

[0045] In the context of the present invention, any device capable of detecting electromagnetic radiation is included in the term "detection element 34". For example, a charge coupling device (CCD), a photodiode, a photodiode array. In addition, the detection element 34 can be adapted in such a way that the detected radiation and the corresponding generated information can be transmitted to a memory, a computer or another control unit.

[0046] In the context of the present invention, the "driver" can be selected according to the motion trajectory required by the first installation unit 100, including a robot operating arm, a telescopic device, a reciprocating mobile device, a swing driving device, etc., and also includes a servo motor, a rotary hydraulic cylinder and other devices that directly provide rotational power, and also includes other devices that indirectly provide power. All of the above can be implemented in the prior art and will not be described one by one here.

[0047] "Sample" In the context of the present invention, the term "sample" as used shall refer to any kind of substance, including one or several components that are detected by optical detection, e.g. by optical excitation and subsequent optical reading. For example, biochemical substances may be analyzed in the context of the present invention. Furthermore, the sample may be a substance used in the field of molecular diagnostics, clinical diagnostics, gene and protein expression arrays. The components of the sample (components to be detected) may in particular be any substance that can be copied by PCR.

[0048] Based on any of the above embodiments, in one embodiment, the optical detection device further includes a first lens 26, which is disposed between the excitation chip 300 and the light emitting element 24. In this way, when the optical detection device is used for in vitro diagnostic analysis, the light emitted by the light emitting element 24 is collected by the first lens 26 and then emitted to the excitation chip 300, and the incident light can be collimated and reflected by the dichroic mirror 200, and then focused on the sample cavity 52 by the third lens 42.

[0049] Optionally, the first lens 26 is fixed on the second mounting unit 22, and the first lens 26 is disposed between the excitation sheet 300 and the light-emitting element 24. In this way, the first lens 26 is integrated into the light-emitting module by using the second mounting unit 22.

[0050] Or in another embodiment, the optical detection device further includes a second lens 36, which is disposed between the emission sheet 400 and the detection element 34. In this way, the sample in the sample cavity 52 is excited by the light of the light emitting element 24 to emit fluorescence, which is collected by the third lens 42, emitted to the dichroic mirror 200, emitted to the emission sheet 400 via the dichroic mirror 200, and emitted to the second lens 36 after passing through the emission sheet 400, and the second lens 36 focuses the fluorescence onto the detection element 34, thereby improving the detection accuracy and sensitivity.

[0051] Optionally, the second lens 36 is fixed on the third mounting unit 32. In this way, the second lens 36 is integrated into the detection module 30 by using the third mounting unit 32.

[0052] Or in another embodiment, if Figures 2 to 4As shown, the optical detection device further includes a first lens 26, which is disposed between the excitation plate 300 and the light-emitting element 24; the optical detection device further includes a second lens 36, which is disposed between the emission plate 400 and the detection element 34. In this way, when the optical detection device is applied to in vitro diagnostic analysis, the light emitted by the light-emitting element 24 is concentrated by the first lens 26 and then emitted to the excitation plate 300, which is conducive to concentrating the light energy and then emitting it to the dichroic mirror 200, and then emitting it to the sample cavity 52 after being reflected by the dichroic mirror 200; the sample in the sample cavity 52 is excited by the light of the light-emitting element 24 to emit fluorescence, and the fluorescence will be emitted to the dichroic mirror 200, and then to the emission plate 400 through the dichroic mirror 200, and then to the second lens 36 after passing through the emission plate 400, and the second lens 36 will focus the fluorescence on the detection element 34, thereby improving the detection accuracy and sensitivity.

[0053] like Figures 3 to 6 As shown, on the basis of any of the above embodiments, in one embodiment, the first mounting unit 100 is provided with an optical path channel 110, and the optical path channel 110 includes a first channel 112, a second channel 114 and a common channel 116, the first channel 112 and the second channel 114 are staggered and perpendicular, and one end of the first channel 112 and one end of the second channel 114 are connected to one end of the common channel 116 to form a common cavity 118; the lens module 10 corresponds one-to-one to the optical path channel 110, the dichroic mirror 200 is arranged in the common cavity 118, the excitation plate 300 is arranged in the first channel 112, and forms an excitation light path with the dichroic mirror 200, and the emission plate 400 is arranged in the second channel 114, and forms an emission light path with the dichroic mirror 200. In this way, when the optical detection device is used, the first installation unit 100 is used to form an optical path channel 110 including a first channel 112, a second channel 114 and a common channel 116, and then the dichroic mirror 200, the excitation plate 300 and the emission plate 400 are integrated into the optical path channel 110, so that the excitation plate 300 and the dichroic mirror 200 form an excitation optical path, the emission plate 400 and the dichroic mirror 200 form an emission optical path, and the light emitting element 24 and the detection element 34 are arranged at intervals along the movement track of the first installation unit 100. In this way, the switching of the optical path channel 110 can be achieved by rotating or moving the first installation unit 100 by a driver, so that the optical path channel 110 can be selectively docked with the light emitting element 24 and the detection element 34 to achieve the detection of different types of target objects of the target sample. In this process, the light source module 20 and the detection element 34 do not need to be rotated, and there will be no winding problem, so there is no need to set up a winding avoidance space. The optical detection device adopts the above-mentioned lens module 10, and can independently drive the lens module 10 to move, thereby avoiding the problem of winding wires, and has a more flexible design, which is conducive to the miniaturization of in vitro diagnostic analysis systems.

[0054] Specifically, in combination with the first lens 26 and the second lens 36, when the optical detection device is applied to in vitro diagnostic analysis, the light emitted by the light emitting element 24 passes through the first lens 26 and the excitation plate 300 and then is emitted to the dichroic mirror 200, and then is reflected by the dichroic mirror 200 and then is emitted to the sample chamber 52 (in this process, the third lens 42 can also be used for focusing), and the sample in the sample chamber 52 is excited by the light of the light emitting element 24 to emit fluorescence, which is collected by the third lens 42 and then emitted to the dichroic mirror 200, and then emitted to the emission plate 400 through the dichroic mirror 200, and then emitted to the second lens 36 after passing through the emission plate 400, and then the fluorescence is focused onto the detection element 34 by the second lens 36. After completing the detection of one type of target, the driver drives the first mounting unit 100 to rotate so that the optical path channel 110 corresponds to another light emitting element 24 and another detection element 34, and the above operation is continued to complete the detection of another type of target.

[0055] Based on any of the above embodiments, Figure 5 and Figure 6 As shown, in one embodiment, the first installation unit 100 includes a light shield 120, a first plate 130 and a second plate 140. The light shield 120 is provided with a light path channel 110. At least two light shields 120 are sandwiched between the first plate 130 and the second plate 140. The first plate 130 is arranged above the light shield 120. The first plate 130 is provided with a first through hole 132 communicating with the second channel 114. The second plate 140 is provided with a second through hole 142 communicating with the common channel 116. In this way, the combination of the light shield 120, the first plate 130 and the second plate 140 realizes the formation of at least two light path channels 110, which is convenient for installing the lens module 10, and is convenient for design and combination. It also allows the first plate 130 and the second plate 140 to move with the lens module 10.

[0056] Furthermore, if Figures 1 to 5 As shown, in one embodiment, there are at least two optical channels 110. In this way, the optical channels 110 can correspond to the detection modules 30 and the light source modules 20 one by one, so that different types of target detection objects of different samples can be detected, and at least two types of target detection objects of at least two chambers can be detected at one time; at the same time, the optical channels are arranged in the light shield, which can avoid light pollution and affect the detection accuracy.

[0057] Furthermore, if Figure 5 and Figure 6 As shown, in one embodiment, at least two light shields 120 are sandwiched between the first plate 130 and the second plate 140 along the same circumference to form a set of mounting modules, and the first mounting unit 100 includes one or more sets of mounting modules. In this way, a mounting module can be formed to facilitate modular assembly.

[0058] Furthermore, the first installation unit 100 includes two or more sets of installation modules stacked vertically. In this way, the longitudinal space of the optical detection device can be fully utilized, and two or more sets of installation modules can be stacked vertically without affecting each other, which is conducive to integrating more light source modules and detection modules, and is convenient for improving detection efficiency. At the same time, modular assembly can be performed, which is conducive to reducing manufacturing costs.

[0059] Of course, in other embodiments, other methods may be used to form a desired structure on the first mounting unit 100 .

[0060] Based on any of the above embodiments, in one embodiment, the lens assembly 200 also includes a first refractive element, which is arranged in the first channel 112 and is arranged between the excitation plate 220 and the dichroic mirror 210 or between the excitation plate 220 and the first lens 26; or the lens assembly 200 also includes a second refractive element, which is arranged in the second channel 114 and is arranged between the emission plate 230 and the dichroic mirror 210 or between the emission plate 230 and the second lens 36; the lens assembly 200 also includes a first refractive element, which is arranged in the first channel 112 and is arranged between the excitation plate 220 and the dichroic mirror 210; and the lens assembly 200 also includes a second refractive element, which is arranged in the second channel 114 and is arranged between the emission plate 230 and the dichroic mirror 210. In this way, the light path is changed by using the first refracting element and / or the second refracting element, so that the detection unit 40 and the light emitting unit 30 can be arranged more flexibly and can be arranged more flexibly in the internal space of the in vitro diagnostic analysis system.

[0061] It should be noted that the “first refractive element” and the “second refractive element” include but are not limited to any existing technology implementations such as reflectors, prisms, optical fibers, etc. that can achieve light path change.

[0062] Based on any of the above embodiments, Figure 3 As shown, in one embodiment, the optical detection device further includes a third lens 42, which is disposed between the dichroic mirror 200 and the sample tray 50. The third lens 42 can better focus the light into the sample cavity 52 of the sample tray 50.

[0063] Optionally, the third lens 42 may be directly integrated into the first mounting unit 100 and move synchronously with the first mounting unit 100 .

[0064] or, as Figure 1 As shown, in one embodiment, the optical detection device further includes an integrated component 40, and the third lens 42 is fixedly disposed in the integrated component 40, and the integrated component 40 is fixedly disposed between the first mounting unit 100 and the sample tray 50. In this way, the third lens 42 can be modularly assembled using the integrated component 40, which facilitates modular assembly.

[0065] Of course, the integrated component 40 can be further integrated into the first installation unit 100 and can move synchronously with the first installation unit 100 .

[0066] Of course, in other embodiments, the third lens 42 may also be integrated into the sample tray 50; or other mounting structures.

[0067] It should be noted that the "first installation unit 100" can be any installation structure that can realize the installation of the above-mentioned parts, such as a mounting bracket, a mounting seat, a mounting frame, a mounting shell, etc.

[0068] The “second mounting unit 22 ” can be any mounting structure such as a mounting bracket, a mounting seat, a mounting shell, etc. that can realize the installation of the above-mentioned parts.

[0069] The “second mounting unit 22 ” can be any mounting structure such as a mounting bracket, a mounting seat, a mounting plate, a mounting shell, etc. that can realize the installation of the above-mentioned parts.

[0070] like Figure 2 and Figure 3 As shown, in one embodiment, each light emitting member 24 is arranged along the same circumference, each detection element 34 is arranged along another circumference, and the driver is used to drive the first mounting unit 100 to rotate along the center of the same circle. In this way, the detection of different target detection objects can be achieved by simply rotating, and the control is simple and easy to implement; in this process, the light source module 20 and the detection element 34 do not need to be rotated, and there will be no winding problem, so there is no need to set up a winding avoidance space, so that the volume of the optical detection device can be smaller. At the same time, at least two light shields 120 are sandwiched between the first plate body 130 and the second plate body 140 along the same circumference to form a group of mounting modules, and the first mounting unit 100 includes at least two groups of mounting modules arranged vertically stacked. In this way, more components can be integrated by rotation to achieve synchronous detection of more sample chambers 52.

[0071] Of course, in another embodiment, the light emitting elements 24 are arranged at intervals along a straight line, and the detection elements 34 are arranged at intervals along another straight line, and the driver is used to drive the first mounting unit 100 to reciprocate along the straight line. In this way, the detection of different target detection objects can be achieved by only reciprocating along the straight line direction; in this process, the light source module 20 and the detection module 30 do not need to rotate, and there will be no winding problem, so there is no need to set up winding avoidance space, so that the volume of the optical detection device can be smaller.

[0072] On the other hand, the present application also provides an in vitro diagnostic analysis system, comprising the optical detection device in any of the above embodiments.

[0073] The in vitro diagnostic analysis system uses the optical detection device, which can independently drive the lens module 10, the light source module 20 or the detection module 30 to move, and the design is more flexible and easier to control.

[0074] Furthermore, the in vitro diagnostic analysis system further includes a sample tray 50, which is provided with a detection cavity corresponding to the free end of the common channel 116, and a third lens 42 is provided between the detection cavity and the common channel 116. In this way, the light emitted by the light emitting element 24 passes through the first lens 26 and the excitation plate 300 and then is emitted to the dichroic mirror 200, and then is reflected by the dichroic mirror 200 and is focused by the third lens 42, and then is emitted to the sample cavity 52. ​​The sample in the sample cavity 52 is excited by the light of the light emitting element 24 to emit fluorescence, and the fluorescence will be emitted to the dichroic mirror 200, and then to the emission plate 400 through the dichroic mirror 200, and then to the second lens 36 after passing through the emission plate 400, and the fluorescence will be focused on the detection element 34 by the second lens 36. After completing the detection of one type of target, the driver drives the first mounting unit 100 to rotate so that the optical path channel 110 corresponds to another light emitting element and another detection element, and the above operation is continued to complete the detection of another type of target.

[0075] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0076] The above embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for those of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. An optical detection device, characterized in that: include: A lens module, the lens module comprising a first mounting unit, a dichroic mirror, an excitation plate and an emission plate, the dichroic mirror and the excitation plate are arranged at intervals on the first mounting unit, and cooperate with the excitation plate to form an excitation light path, the dichroic mirror and the emission plate are arranged at intervals on the first mounting unit, and cooperate with the emission plate to form an emission light path; A light source module, the light source module comprising a second mounting unit and at least two light emitting elements, each of the light emitting elements being arranged on the second mounting unit with a spacing therebetween, and each of the light emitting elements being arranged with a spacing from the excitation plate; A detection module, the detection module comprising a third mounting unit and at least two detection elements, each of the detection elements being arranged on the third mounting unit with a spacing therebetween, and each of the detection elements being arranged with a spacing from the transmitting sheet; and a driver for driving the first mounting unit, for driving the first mounting unit and the second mounting unit, or for driving at least one of the first mounting unit and the third mounting unit to move; The first mounting unit is provided with an optical path channel, the optical path channel includes a first channel, a second channel and a common channel, the first channel is staggered with the second channel, and one end of the first channel and one end of the second channel are both connected with one end of the common channel to form a common cavity; the lens module corresponds to the optical path channel one by one, the dichroic mirror is arranged in the common cavity, the excitation plate is arranged in the first channel, and forms an excitation optical path with the dichroic mirror, and the emission plate is arranged in the second channel, and forms an emission optical path with the dichroic mirror; The first mounting unit includes a light shield, a first plate and a second plate. The light shield is provided with an optical path channel. The light shield is sandwiched between the first plate and the second plate. The first plate is arranged above the light shield. The first plate is provided with a first through hole communicating with the second channel. The second plate is provided with a second through hole communicating with the common channel.

2. The optical detection device according to claim 1, characterized in that: The light emitting members are spaced apart along the same circumference, the detection elements are spaced apart along another circumference, and the driver is used to drive the first mounting unit to rotate along the center of the same circumference.

3. The optical detection device according to claim 1, characterized in that: The light emitting members are spaced apart along a straight line, the detection elements are spaced apart along another straight line, and the driver is used to drive the first mounting unit to reciprocate along the straight line.

4. The optical detection device according to claim 1, characterized in that: The optical detection device further includes a first lens, which is arranged between the excitation plate and the light-emitting element; or / and the optical detection device further includes a second lens, which is arranged between the emission plate and the detection element.

5. The optical detection device according to claim 1, characterized in that: There are at least two optical path channels, and the light shields correspond to the optical path channels one by one.

6. The optical detection device according to claim 5, characterized in that: At least two light shields are sandwiched between the first plate body and the second plate body along the same circumference at intervals to form a group of mounting modules, and the first mounting unit includes one or more groups of the mounting modules.

7. The optical detection device according to claim 6, characterized in that: The first installation unit includes two or more groups of the installation modules that are vertically stacked.

8. The optical detection device according to claim 4, characterized in that: The lens module also includes a first refractive element, which is arranged in the first channel and between the excitation plate and the dichroic mirror or between the excitation plate and the first lens; or / and the lens module also includes a second refractive element, which is arranged in the second channel and between the emission plate and the dichroic mirror or between the emission plate and the second lens.

9. The optical detection device according to claim 1, characterized in that: The optical detection device further includes a third lens, which is disposed between the dichroic mirror and the sample disk.

10. The optical detection device according to claim 9, characterized in that: The optical detection device further comprises an integrated component, the third lens is fixed in the integrated component, and the integrated component is fixed between the first mounting unit and the sample tray.

11. An in vitro diagnostic analysis system, characterized in that: Comprising the optical detection device according to any one of claims 1 to 10.

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