Sample placement device and immunoassay analyzer

Abstract

The present invention belongs to the field of medical testing, and discloses a sample placement device and an immunoassay analyzer. The sample placement device includes a main body, and the main body is provided with a reagent placement chamber and a detection chamber, the reagent placement chamber is isolated from the detection chamber, the detection chamber is provided with a detection opening, and the wall of the detection chamber isolates the external light source. The external light source is blocked by the wall of the detection chamber, so as to improve the detection accuracy.

Description

Technical Field

[0001] The invention belongs to the field of medical detection, in particular to a sample placing device and an immunoanalyzer. Background Art

[0002] As people's living standards improve, they pay more and more attention to their health, so more and more physical examination projects are being carried out, such as the use of liquid luminescence immunoassay analyzers for clinical testing. Liquid luminescence immunoassay analyzers have a variety of test items and are capable of testing and screening for a variety of diseases. However, in existing products, the test results are easily affected by external light sources when the sample placement device is tested. Summary of the invention

[0003] The purpose of the present invention is to improve the shortcomings of the prior art and provide a sample placement device and an immunoassay analyzer to block external light sources and improve detection accuracy.

[0004] The technical solution is as follows:

[0005] The sample placement device comprises a main body, on which a reagent placement chamber and a detection chamber are arranged, the reagent placement chamber is isolated from the detection chamber, the detection chamber is provided with a detection opening, and the wall of the detection chamber isolates the external light source.

[0006] The detection chamber comprises a detection bottle and a covering sleeve, wherein the covering sleeve covers the side wall of the detection bottle, and the side wall of the detection bottle and / or the covering sleeve isolate the external light source.

[0007] The covering sleeve is made of at least one of black plastic material, black rubber or black silicone material.

[0008] The covering sleeve is provided with a clamping groove surrounding the detection bottle.

[0009] Two detection bottles are provided, and the covering sleeve covers the two detection bottles.

[0010] A limiting column is arranged on the outer side of the covering sleeve, a limiting groove matching with the limiting column is arranged on the main body, the covering sleeve is installed on the main body, and the limiting column cooperates with the limiting groove for limiting.

[0011] A buckling protrusion is arranged on the outer side of the covering sleeve, a buckling groove matching the buckling protrusion is arranged on the main body, the covering sleeve is installed on the main body, and the buckling protrusion is clamped on the buckling groove.

[0012] It also includes a reagent placement bottle. The main body is provided with a first placement hole, and the reagent placement bottle is placed on the first placement hole.

[0013] It also includes a movable suction head. The main body is provided with a second placement hole, and the movable suction head is placed on the second placement hole.

[0014] The main body is provided with a sample chamber, and the detection chamber, the reagent placement chamber and the sample chamber are arranged in a row.

[0015] The immunoassay analyzer comprises a support frame, a sample delivery component, an extraction manipulator and a detection component. The sample delivery component, the extraction manipulator and the detection component are all installed on the support frame, and the sample placement device is placed on the sample delivery component.

[0016] The technical solution provided by the present invention has the following advantages and effects:

[0017] The reagent placement chamber is used to place reagents for the reaction, while the detection chamber is used to place samples to be tested. The reagents and samples are placed separately. When testing is required, both the reagents and samples are extracted to the detection chamber. The walls of the detection chamber are isolated from external light sources. Therefore, when the detection component detects the sample in the detection chamber through the detection opening, the walls of the detection chamber are not light-transmissive, and external light sources are not easy to interfere with the detection, making the detection more accurate. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The accompanying drawings herein show specific examples of the technical solutions described in the present invention, and together with the specific implementation methods, constitute a part of the specification, and are used to explain the technical solutions, principles and effects of the present invention.

[0019] Unless otherwise specified or defined, the same reference numerals in different drawings represent the same or similar technical features, and the same or similar technical features may also be represented by different reference numerals.

[0020] Figure 1 is a schematic diagram of the three-dimensional structure of the immunoassay analyzer according to an embodiment of the present invention from a first perspective;

[0021] Figure 2 is a schematic diagram of the three-dimensional structure of the immunoassay analyzer according to the embodiment of the present invention from a second viewing angle;

[0022] Figure 3 It is a schematic diagram of the structure of the sample delivery component in motion state according to an embodiment of the present invention;

[0023] Figure 4 2 is a schematic structural diagram of a sample delivery component in motion state 2 according to an embodiment of the present invention;

[0024] Figure 5 is a schematic diagram of the exploded structure of the sample delivery component of an embodiment of the present invention from one perspective;

[0025] Figure 6 is a schematic diagram of the exploded structure of the sample delivery component of an embodiment of the present invention from a second perspective;

[0026] Figure 7 is a schematic diagram of the three-dimensional structure of a vibration seat according to an embodiment of the present invention;

[0027] Figure 8 is a schematic cross-sectional structural diagram of the vibration part of the sample delivery component of an embodiment of the present invention;

[0028] Fig. 9 The embodiment of the present invention Figure 8 A schematic diagram of the structure enlargement in the middle;

[0029] Fig.10 is a schematic diagram of the three-dimensional structure of a sample placement device according to an embodiment of the present invention;

[0030] Fig.11 is a schematic diagram of the exploded structure of a sample placement device according to an embodiment of the present invention;

[0031] Fig.12 The embodiment of the present invention Fig.11 A magnified schematic diagram of the structure at B in the middle;

[0032] Fig.13 is a schematic diagram of the exploded structure of an extraction manipulator according to an embodiment of the present invention;

[0033] Fig.14 1 is a schematic diagram of the state of the extraction robot according to an embodiment of the present invention;

[0034] Fig.15 The embodiment of the present invention Fig.14 Schematic diagram of the cross-section structure;

[0035] Fig.16 The embodiment of the present invention Fig.15 The enlarged structural diagram at C in the middle;

[0036] Fig.17 This is a schematic diagram of the structure of the extraction robot in state 2 according to an embodiment of the present invention;

[0037] Fig.18 The embodiment of the present invention Fig.17 Schematic diagram of the cross-section structure;

[0038] Fig.19 2. It is a schematic diagram of the back structure of the extraction robot according to an embodiment of the present invention;

[0039] Fig. 20 is a schematic diagram of a structure of a detection component state according to an embodiment of the present invention;

[0040] Fig.21 is a schematic diagram of the back structure of the detection component state of an embodiment of the present invention;

[0041] Fig. 22 is a schematic diagram of the second structure of the detection component state of an embodiment of the present invention;

[0042] Fig.23 The embodiment of the present invention Fig. 22 The enlarged structural diagram at D in the middle;

[0043] Fig.24 is a schematic cross-sectional structural diagram of a detection part of a detection assembly according to an embodiment of the present invention;

[0044] Fig.25 The embodiment of the present invention Fig.24 The enlarged structural diagram at E in the middle;

[0045] Fig.26 The embodiment of the present invention Fig.24 Enlarged structural diagram at F in the middle.

[0046] Description of reference numerals:

[0047] 10. Support frame; 11. Sample delivery track;

[0048] 20. Sample delivery assembly; 21. Sample delivery slide; 22. Bearing sleeve; 221. Rotating bearing; 222. Flange boss; 2221. Convex ring; 23. Bearing seat; 231. Bearing installation position; 232. Empty position; 24. Fixed platform; 241. Vibration photoelectric detection switch; 25. Eccentric shaft; 251. First eccentric section; 252. Second eccentric section; 253. Vibration position detection plate; 26. Receiver; 261. Receiver position; 262. First boss; 2621. Ring groove; 27, power part; 271, vibration motor; 272, vibration transmission mechanism; 2721, first vibration pulley; 2722, second vibration pulley; 2723, vibration transmission belt; 28, vibration seat; 281, fixing part; 2811, transmission hole; 282, vibration part; 2821, first groove; 283, vibration arm; 291, first sample delivery pulley; 292, second sample delivery pulley; 293, sample delivery transmission belt; 294, sample delivery motor;

[0049] 30. Extraction manipulator; 31. Mounting frame; 32. Lifting drive group; 321. Lifting drive member; 3211. Lifting screw motor; 322. Lifting drive seat; 3221. Film piercing rod; 33. Liquid suction drive group; 331. Liquid suction drive member; 3311. Liquid suction screw motor; 3312. Liquid suction drive seat; 3313. Blocking block; 332. Liquid suction member; 3321. Extraction plug rod; 3322. Liquid suction chamber; 33221. Liquid suction cavity; 33222. Liquid suction port; 3323. Liquid suction tube; 34. Lifting position detection switch; 35. Liquid suction position detection switch;

[0050] 40. Detection assembly; 41. First detection drive group; 411. First detection lead screw motor; 42. Second detection drive group; 421. Second detection motor; 422. Detection belt group; 43. Adapter plate; 44. Shading drive member; 441. Shading lead screw motor; 442. Shading drive seat; 45. Shading plate; 46. Light path guide; 461. First light source detection port; 462. Second light source detection port; 463. Light source input port; 464. Sample detection port; 465. Spectrophotometer Plate; 4651, first action surface; 4652, second action surface; 466, optical lens; 4671, first filter; 4672, second filter; 468, sealing element; 469, joint; 471, second detection rail; 472, second detection drive seat; 473, light source; 474, spring; 475, label detector; 476, first detection rail; 477, first detection drive seat; 478, first photoelectric detector; 479, second photoelectric detector;

[0051] 50. Sample placement device; 51. Main body; 511. Reagent placement chamber; 512. Detection chamber; 5121. Detection bottle; 51211. Detection opening; 5122. Covering sleeve; 51221. Positioning groove; 51222. Limiting column; 51223. Snap-fit ​​protrusion; 513. Limiting groove; 514. Snap-fit ​​groove; 515. First placement hole; 516. Second placement hole; 517. Sample chamber; 52. Reagent placement bottle; 53. Movable suction head. DETAILED DESCRIPTION

[0052] In order to facilitate the understanding of the present invention, specific embodiments of the present invention will be described in more detail below with reference to the accompanying drawings.

[0053] Unless otherwise specified or defined, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art. In the case of combining the technical solution of the present invention with a realistic scenario, all technical and scientific terms used herein may also have meanings corresponding to the purpose of implementing the technical solution of the present invention.

[0054] Unless otherwise specified or defined, the "first, second..." used in this article is merely used to distinguish names and does not represent a specific quantity or order.

[0055] Unless specifically stated or defined otherwise, the term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0056] It should be noted that when a component is considered to be "fixed to" another component, it can be directly fixed to the other component or there can be a central component; when an component is considered to be "connected to" another component, it can be directly connected to the other component or there can be a central component at the same time; when an component is considered to be "installed on" another component, it can be directly installed on the other component or there can be a central component at the same time. When an component is considered to be "set on" another component, it can be directly set on the other component or there can be a central component at the same time.

[0057] It should be noted that in this embodiment, the sample includes reagents and samples. The reagents are such as reaction reagents, and the samples are such as blood samples.

[0058] like Figures 1 to 3 as well as Fig.25 As shown, the immunoassay analyzer includes a support frame 10, a sample delivery component 20, an extraction robot 30 and a detection component 40, wherein the sample delivery component 20, the extraction robot 30 and the detection component 40 are all installed on the support frame 10; the sample delivery component 20 includes a receiving seat 26, a receiving position 261 is provided on the receiving seat 26, and the detection component 40 is provided with a sample detection port 464; during detection, the receiving seat 26 is moved under the drive of the sample delivery component 20, and the receiving seat 26 is respectively transported to the bottom of the extraction robot 30 and the bottom of the detection component 40, and the sample detection port 464 corresponds to the receiving position 261.

[0059] Sample delivery component 20:

[0060] like Figures 1 to 9 As shown, the sample delivery component 20 includes a sample delivery slide 21, a sample delivery motor 294, a first sample delivery pulley 291, a second sample delivery pulley 292, a sample delivery transmission belt 293, a bearing sleeve 22, a bearing seat 23, a fixed platform 24, an eccentric shaft 25, a power part 27, a receiving seat 26 and a vibration seat 28.

[0061] The support frame 10 is provided with a sample delivery track 11, and the sample delivery slide 21 is slidably matched with the sample delivery track 11. By means of sliding match, the sample delivery slide 21 slides along the sample delivery track 11 on the support frame 10, and the sample delivery track 11 can be directly opened on the support frame 10, or can be processed separately and then fixedly installed on the support frame 10. The sample delivery motor 294 is installed on the support frame 10 or on the sample delivery track 11, the first sample delivery pulley 291 is installed on the output shaft of the sample delivery motor 294, the second sample delivery pulley 292 is installed on the support frame 10 or on the sample delivery track 11 along the sample delivery track 11, the sample delivery transmission belt 293 is installed on the first sample delivery pulley 291 and the second sample delivery pulley 292, and the sample delivery slide 21 is partially fixedly connected with the sample delivery transmission belt 293. In this embodiment, the sample feeding motor 294 is fixedly installed on the sample feeding track 11, and then the first sample feeding pulley 291 is driven to rotate by the rotation of the sample feeding motor 294, thereby pulling the sample feeding transmission belt 293 to move, and the sample feeding slide 21 is partially fixed to the sample feeding transmission belt 293, so when the sample feeding transmission belt 293 moves, the sample feeding slide 21 also moves therewith, that is, the sample feeding slide 21 slides along the sample feeding track 11 driven by the sample feeding transmission belt 293.

[0062] like Figures 5 to 9 As shown, the fixed platform 24 is mounted on the sample delivery assembly 20, the power member 27 is fixedly mounted on the fixed platform 24, a transmission hole 2811 is provided on the vibration seat 28, the eccentric shaft 25 has a first eccentric segment 251 and a second eccentric segment 252, the first eccentric segment 251 is rotatably mounted on the fixed platform 24, the second eccentric segment 252 passes through the transmission hole 2811 and cooperates with the transmission hole 2811, the power member 27 drives the first eccentric segment 251 to rotate, and the second eccentric segment 252 drives the vibration seat 28 to vibrate. The power member 27 drives the first eccentric segment 251 to rotate, and the first eccentric segment 251 rotates on the fixed platform 24. At this time, the axis of the first eccentric segment 251 is the rotation center, while the axis of the second eccentric segment 252 is different from the axis of the first eccentric segment 251. When the second eccentric segment 252 rotates, the rotation center is different from the axis of the second eccentric segment 252, so the second eccentric segment 252 rotates with an offset. The second eccentric section 252 cooperates with the transmission hole 2811 , and the vibration seat 28 generates a vibration effect under the offset rotation of the second eccentric section 252 .

[0063] like Figure 5 and Figure 6As shown, the power member 27 includes a vibration motor 271 and a vibration transmission mechanism 272. The vibration motor 271 drives the eccentric shaft 25 to rotate through the vibration transmission mechanism 272. The vibration motor 271 provides power and drives the eccentric shaft 25 to rotate through the vibration transmission mechanism 272.

[0064] Specifically, Figure 5 and Figure 6 As shown, the vibration transmission mechanism 272 includes a first vibration pulley 2721, a second vibration pulley 2722 and a vibration transmission belt 2723, wherein the first vibration pulley 2721 is mounted on the vibration motor 271, the second vibration pulley 2722 is mounted on the first eccentric section 251, and the vibration transmission belt 2723 is mounted on the first vibration pulley 2721 and the second vibration pulley 2722. Driven by the vibration transmission belt 2723, the power of the vibration motor 271 is transmitted to the first eccentric section 251. Compared with the transmission by gear meshing, the belt transmission method can reduce the overall weight of the vibration transmission mechanism 272, and the cost is more economical. It is more convenient to adjust the tightness, and since the contact between the first vibration pulley 2721 and the second vibration pulley 2722 and the vibration transmission belt 2723 is not a hard contact, it has a buffering effect, so the noise problem can be effectively reduced.

[0065] like Figures 3 to 5 As shown, the vibrating seat 28 is installed with the receiving seat 26, the vibrating seat 28 is fixedly connected with the receiving seat 26, and the transmission hole 2811 is arranged on the vibrating seat 28. The receiving seat 26 is used to place the sample, so the reaction of the sample can be accelerated under the vibration of the vibrating seat 28, thereby shortening the reaction time, which is conducive to accelerating the detection; and the vibration makes the reagent react more fully, which is conducive to improving the accuracy of the detection.

[0066] like Figure 6 and Figure 7As shown, the vibration seat 28 includes a fixed portion 281 and a vibration portion 282, the transmission hole 2811 is arranged on the vibration portion 282, the fixed portion 281 is installed on the fixed platform 24, and the fixed portion 281 and the vibration portion 282 are connected by a vibration arm 283; the connection point between the vibration arm 283 and the fixed portion 281 is a first connection point, and the connection point between the vibration arm 283 and the vibration portion 282 is a second connection point, and the line connecting the first connection point and the second connection point is not in the same plane as the axis of the transmission hole 2811. The fixed portion 281 is installed on the fixed platform 24 to fix the vibration seat 28, and then the vibration portion 282 is driven by the second eccentric section 252. Since the fixed portion 281 and the vibration portion 282 are connected by the vibration arm 283, the fixed portion 281 and the vibration portion 282 are not relatively fixed and cannot move relative to each other, but when the vibration portion 282 vibrates, the vibration arm 283 is bent to complete the vibration, so that the vibration portion 282 generates vibration. In addition, since there are many ways to set the vibration arm 283, when the vibration direction is perpendicular to the vibration arm 283, vibration will not occur, so the line connecting the first connection point and the second connection point is not in the same plane as the axis of the transmission hole 2811, that is, their extended lines cannot intersect in space.

[0067] like Figures 5 to 7 As shown, the top of the vibration seat 28 is provided with a first groove 2821, and the bottom of the receiving seat 26 is provided with a first boss 262 matching the first groove 2821, and the first groove 2821 is clamped with the first boss 262. The clamping cooperation between the first groove 2821 and the first boss 262 plays a positioning role, and then the vibration seat 28 and the receiving seat 26 are pressed by the nail body, so that the vibration seat 28 and the receiving seat 26 vibrate as a whole during vibration.

[0068] The bearing sleeve 22 is provided with a rotating bearing 221, the second eccentric section 252 passes through the rotating bearing 221 installed on the bearing sleeve 22, and the bearing sleeve 22 passes through the transmission hole 2811. In order to avoid wear between the second eccentric section 252 and the vibration seat 28 during cooperation, the bearing sleeve 22 is provided to contact the inner wall of the transmission hole 2811, and then the bearing sleeve 22 and the second eccentric section 252 are rotated through the rotating bearing 221, and the wear during rotation can be effectively offset by the rotating bearing 221. In some embodiments, the bearing sleeve 22 fits the inner wall of the transmission hole 2811, and relative displacement is not easy to occur. In this embodiment, for the sake of balance, two rotating bearings 221 are provided inside the bearing sleeve 22.

[0069] like Figure 8 and Fig. 9As shown, the bearing sleeve 22 is provided with a flange boss 222, and a convex ring 2221 is provided on the top of the flange boss 222 along the axial direction of the bearing sleeve 22, and a ring groove 2621 matching the convex ring 2221 is provided at the bottom of the first boss 262, and the convex ring 2221 is clamped with the ring groove 2621. The convex ring 2221 cooperates with the ring groove 2621 to complete a limit, and then the flange boss 222 is fixedly connected to the bottom of the first boss 262 by the nail body, so in this embodiment, the bearing sleeve 22 is driven by the receiving seat 26, and then the receiving seat 26 drives the vibration seat 28 to vibrate.

[0070] One end of the bearing seat 23 is fixedly mounted on the fixed platform 24. The bearing seat 23 is provided with a bearing installation position 231. A rotating bearing 221 is installed on the bearing installation position 231. The first eccentric section 251 of the eccentric shaft 25 cooperates with the rotating bearing 221 located on the bearing installation position 231. The bearing seat 23 is fixed to the fixed platform 24, and then rotates with the first eccentric section 251 through the rotating bearing 221. Therefore, when the first eccentric section 251 is driven to rotate, the bearing seat 23 only plays a supporting role. In order to ensure stable rotation, two bearing installation positions 231 are provided on the bearing seat 23, and a rotating bearing 221 is installed on each bearing installation position 231.

[0071] like Fig. 9 As shown, an empty space 232 is provided between the two bearing mounting positions 231, and the power member 27 drives the eccentric shaft 25 through the empty space 232. Driving the first eccentric section 251 between the two bearing mounting positions 231 can ensure that the first eccentric section 251 shakes less when rotating. Specifically, the second vibration pulley 2722 is located on the empty space 232, and the vibration transmission belt 2723 can drive the second vibration pulley 2722 through this setting.

[0072] like Figure 8 and Fig. 9 As shown, a vibration position detection plate 253 is installed on the first eccentric section 251, and a vibration photoelectric detection switch 241 is installed on the fixed platform 24, and the vibration position detection plate 253 cooperates with the vibration photoelectric detection switch 241. When the first eccentric section 251 rotates, the vibration position detection plate 253 follows the synchronous rotation. In order to ensure that the position can stay at a fixed position after each vibration, the vibration position detection plate 253 blocks the vibration photoelectric detection switch 241 and provides a pulse signal. Therefore, when it is necessary to stop the vibration, the vibration position detection plate 253 cooperates with the vibration photoelectric detection switch 241 to provide position information, ensuring that the position of the vibration seat 28 when the vibration stops is the same as when the vibration starts.

[0073] Extraction robot 30:

[0074] like Fig.13 As shown, the extraction robot 30 includes a mounting frame 31, a lifting drive group 32 and a liquid suction drive group 33, wherein the lifting drive group 32 is fixedly mounted on the mounting frame 31, and the mounting frame 31 is fixedly mounted on the support frame 10. The mounting frame 31 can form the extraction robot 30 into a module, which is convenient for installation and maintenance.

[0075] like Figures 13 to 15 As shown, the liquid suction drive group 33 is installed on the moving part of the lifting drive group 32. When in use, the liquid suction drive group 33 is lifted up and down by the movement of the lifting drive group 32. When the receiving seat 26 on the sample delivery component 20 has not moved to the bottom of the extraction manipulator 30, the lifting drive group 32 lifts the liquid suction drive group 33 to a high position to avoid blocking the movement of the receiving seat 26. When the receiving seat 26 moves to the bottom of the extraction manipulator 30, the lifting drive group 32 drives the liquid suction drive group 33 to move downward and approach the receiving seat 26, and then the liquid suction drive group 33 sucks the sample on the receiving position 261. After sucking the sample, the lifting drive group 32 continues to lift upward, and then the sample delivery component 20 drives the receiving seat 26, so that the liquid suction drive group 33 faces different positions of the receiving position 261, and the lifting drive group 32 moves downward again, and the liquid suction drive group 33 releases the sample, and this is repeated, so that different samples can be sucked and the reaction of the sample is completed.

[0076] like Fig.13 As shown, the lifting drive group 32 includes a lifting drive member 321 and a lifting drive seat 322. The lifting drive member 321 drives the lifting drive seat 322 to move up and down, and the liquid suction drive group 33 is installed on the lifting drive seat 322. The lifting drive member 321 is used to drive the lifting drive seat 322, so that the lifting drive seat 322 drives the liquid suction drive group 33 to move up and down.

[0077] Specifically, Fig.14 As shown, the lifting drive member 321 is a lifting screw motor 3211, and the lifting screw motor 3211 cooperates with the lifting drive seat 322. The lifting screw motor 3211 is used to drive the lifting drive seat 322 to move up and down by converting the rotation mode into the movement mode.

[0078] like Fig.13 and Fig.14 As shown, the lifting drive group 32 is provided with a film piercing rod 3221, and the setting direction of the film piercing rod 3221 is the same as the driving direction of the lifting drive group 32. The film piercing rod 3221 is used to pierce the sealing film of the packaged sample, and the installation direction of the film piercing rod 3221 is the same as the driving direction of the lifting drive column, to ensure that the film piercing rod 3221 can pierce the sealing film when it moves downward.

[0079] like Figures 13 to 16 As shown, the liquid suction drive group 33 includes a liquid suction drive member 331 and a liquid suction member 332. The liquid suction member 332 is provided with a liquid suction port 33222. The liquid suction drive member 331 drives the liquid suction member 332 to suck liquid.

[0080] like Figures 15 to 18 As shown, the liquid suction drive component 331 includes a liquid suction screw motor 3311 and a liquid suction drive seat 3312, and the liquid suction component 332 includes an extraction plug rod 3321 and a liquid suction chamber 3322 with a liquid suction cavity 33221; the liquid suction screw motor 3311 cooperates with the liquid suction drive seat 3312, and the liquid suction screw motor 3311 and the liquid suction chamber 3322 are fixedly installed on the lifting drive seat 322; one end of the extraction plug rod 3321 is fixedly installed on the liquid suction drive seat 3312, and the other end movably extends into the liquid suction cavity 33221 of the liquid suction chamber 3322, and the liquid suction port 33222 is opened at the lower part of the liquid suction cavity 33221. The liquid suction screw motor 3311 drives the liquid suction drive seat 3312 to move and then drives the extraction plug rod 3321 to move. The extraction plug rod 3321 moves in the liquid suction cavity 33221 of the liquid suction chamber 3322. When the extraction plug rod 3321 moves upward, a negative pressure is formed inside the liquid suction cavity 33221, and the liquid suction port 33222 can absorb liquid. When the liquid needs to be discharged, the liquid suction screw motor 3311 drives the liquid suction drive seat 3312 to move downward, that is, drives the extraction plug rod 3321 to move downward, and discharges the liquid in the liquid suction cavity 33221. When the liquid is sucked in this way, the rotation of the liquid suction screw motor 3311 can be controlled to control the suction and discharge of liquid. Compared with the method of using a pump body, the mechanical setting of this solution is more convenient.

[0081] like Figures 13 to 16 As shown, the extraction plug rods 3321 are provided with three parallel ones, and the liquid suction chamber 3322 is provided with three liquid suction cavities 33221, and each of the extraction plug rods 3321 cooperates with each of the liquid suction cavities 33221. The three extraction plug rods 3321 correspond to the liquid suction cavities 33221, that is, the liquid suction drive seat 3312 can synchronously control two collection plug rods for sucking liquid, and each time a sample is placed, a group of samples can be placed, and the extraction of multiple groups of samples can be completed under the action of a group of extraction manipulators 30, which is conducive to speeding up the detection speed.

[0082] In other embodiments, three suction chambers 3322 each having only one suction cavity 33221 may be provided.

[0083] like Figures 16 to 18As shown, a blocking block 3313 is installed on the liquid suction drive seat 3312, a liquid suction pipe 3323 is arranged at the bottom of the liquid suction chamber 3322, the liquid suction pipe 3323 is communicated with the liquid suction port 33222, the blocking block 3313 is located below the liquid suction chamber 3322, and the liquid suction pipe 3323 passes through the blocking block 3313. In actual use, it is necessary to install the liquid suction pipe 3323, which has an extension effect, and the liquid suction pipe 3323 can be used to install the movable suction head 53, and the movable suction head 53 is made of soft materials such as rubber materials or silicone materials. Each time it is used, the movable suction head 53 actually contacts the liquid first, so the liquid can only stay on the movable suction head 53. After each use, the movable suction head 53 will be contaminated, so after each use, the movable suction head 53 needs to be taken out, so the blocking block 3313 is provided here to remove the movable suction head 53. When it is necessary to remove the movable suction head 53, the suction screw motor 3311 drives the suction drive seat 3312 to move downward, which drives the blocking block 3313 to move downward, and finally the blocking block 3313 contacts the movable suction head 53 installed on the suction tube 3323. The blocking block 3313 continues to move downward to separate the movable suction head 53 from the suction tube 3323. This process can not only remove the movable suction head 53, but also because under the action of the suction drive seat 3312, the extraction plug rod 3321 will move downward to discharge the sucked liquid as much as possible, thereby avoiding the situation of liquid residue.

[0084] like Fig.19 As shown, the extraction manipulator 30 is also provided with a lifting position detection switch 34 and a liquid suction position detection switch 35, both of which adopt a photoelectric detection method. The lifting position detection switch 34 is used to detect the movement position of the lifting drive group 32, prevent the movement from exceeding the position, and stop the driving of the lifting screw motor 3211 in time; while the liquid suction position detection switch 35 is used to detect the movement position of the liquid suction drive group 33, prevent the movement from exceeding the position, and stop the driving of the liquid suction screw motor 3311 in time.

[0085] Detection component 40:

[0086] like Figure 20 to Figure 26 As shown, the detection assembly 40 includes a first detection drive group 41, a second detection guide rail 471, a second detection drive seat 472, a second detection drive group 42, a light source component 473, an optical path guide component 46, a first photodetector 478 and a second photodetector 479.

[0087] like Figure 20 to Figure 23As shown, the second detection guide rail 471 is fixedly mounted on the support frame 10, the second detection drive seat 472 is slidably matched with the second detection guide rail 471, the second detection drive group 42 drives the second detection drive seat 472 to move, and the first detection drive group 41 is mounted on the second detection drive seat 472. The second detection drive seat 472 is slidably matched on the second detection guide rail 471, and the second detection drive group 42 is used to drive the second detection drive seat 472 to slide, and the first detection drive group 41 is mounted on the second detection drive seat 472 so that the first detection drive group 41 can move along the second detection guide rail 471, that is, the optical path detection member can move on the second detection guide rail 471. In the case where the sample delivery assembly 20 is provided with multiple groups, the optical path guide member 46 can be transported to the top of the sample delivery assembly 20 at different positions, so as to detect the samples on different sample delivery assemblies 20.

[0088] like Figure 20 to Figure 23 As shown, the second detection drive group 42 includes a second detection motor 421 and a detection belt group 422. The second detection motor 421 is installed on the second detection rail 471 or the support frame 10. The detection belt group 422 is installed along the second detection rail 471. The second detection motor 421 drives the detection belt group 422 to move. One end of the second detection drive seat 472 is fixedly installed on the detection belt group 422. In the case of a long transmission distance, the second detection drive group 42 adopts a belt conveyor, which can reduce the volume and cost.

[0089] like Figure 21 to Figure 23 As shown, a first detection guide rail 476 is fixedly mounted on the second detection drive seat 472 , a first detection drive seat 477 is slidably mounted on the first detection guide rail 476 , and the first detection guide rail 476 is connected to the first detection drive group 41 .

[0090] The first detection drive group 41 includes a first detection lead screw motor 411 and a first detection drive seat 477. The first detection lead screw motor 411 is mounted on the first detection guide rail 476. The first detection drive seat 477 is fixed to the optical path guide 46 via a receiving plate 43. Here, the first detection lead screw motor 411 is used to drive the optical path guide 46 to move up and down, converting rotation into movement, which occupies a small space, and the optical path guide 46 can be directly controlled by controlling the first detection lead screw motor 411.

[0091] During detection, the sample delivery component 20 will enter the bottom of the detection component 40. When the sample delivery component 20 transports the sample to the bottom of the detection component 40, the first drive group will lift the light path guide 46. When the sample is delivered to the bottom of the detection component 40, the first detection drive group 41 will move the light path guide 46 downward for detecting the sample.

[0092] like Fig. 22 and Fig.23 As shown, a spring 474 is provided between the receiving plate 43 and the first detection drive seat 477, so that the receiving plate 43 is elastically connected to the first detection drive seat 477. The receiving plate 43 plays a connecting role, and the setting of the spring 474 can ensure that there is elasticity between the receiving plate 43 and the first detection drive seat 477, that is, there is elasticity between the optical path guide 46 connected by the receiving plate 43 and the first detection drive seat 477, so when the optical path guide 46 moves downward to approach the sample, a squeeze contact occurs, and the elasticity can also be used to rebound to avoid hard contact.

[0093] like Fig. 20 and Fig.23 As shown, a label detector 475 is installed on the receiving plate 43, and the detection direction of the label detector 475 is downward. The label detector 475 is used to detect the label of the sample, and there is no need to manually input the sample information, so it is beneficial to increase the automatic detection rate.

[0094] like Figure 1 and Figure 2 as well as Figures 20 to 25 As shown, the optical path guide 46 is provided with a light source input port 463, a first light source detection port 461, a sample detection port 464 and a second light source detection port 462. The light emitting end of the light source 473 is opposite to the light source input port 463, and the first light source detection port 461 is opposite to the sensing position of the first photodetector 478. The detection light emitted by the light source 473 enters the optical path guide 46 through the light source input port 463, passes through the sample detection port 464 after being guided, and is emitted to the sample. The light is irradiated on the sample, and the sample excites fluorescence. The fluorescence enters the optical path guide 46 through the sample detection port 464, and then passes through the first light source detection port 461 to enter the first photodetector 478. The first photodetector 478 detects the fluorescence for analyzing the fluorescence information.

[0095] like Fig.25 As shown, the second light source detection port 462 is opposite to the sensing position of the second photodetector 479. Most of the detection light emitted by the light source 473 passes through the sample detection port 464, while a smaller portion of about 1% to 7% of the detection light passes through the second light source detection port 462 and is detected by the second photodetector 479. The second photodetector 479 detects the intensity change of the detection light emitted by the light source 473, which is used to adjust the fluorescence information detected by the first photodetector 478 to avoid affecting the detection accuracy of the first photodetector 478 due to the instability of the light source 473.

[0096] like Fig.24 and Fig.25As shown, a beam splitter 465 is arranged inside the optical path guide 46, and the beam splitter 465 has two opposite first and second action surfaces 4651 and 4652, the channel connecting the light source input port 463 and the second light source detection port 462 is the first light path channel, the channel connecting the sample detection port 464 and the first light source detection port 461 is the second light path channel, the first light path channel and the second light path channel intersect, the beam splitter 465 is installed at the intersection of the first light path channel and the second light path channel, and the first action surface 4651 faces the light source input port 463 and the sample detection port 464, and the second action surface 4652 faces the first light source detection port 461 and the second light source detection port 462. The beam splitter 465 can reflect most of the light and then transmit a small amount of light. When the light source 473 emits detection light, most of the light is reflected and enters the sample detection port 464, and a small amount of detection light passes through the beam splitter 465 to enter the second light source detection port 462 and is detected by the second photodetector 479; and part of the fluorescence excited by the sample passes through the beam splitter 465 and is detected by the first photodetector 478 through the first light source detection port 461.

[0097] The beam splitter 465 may be a dichroic mirror, which can be used to transmit the fluorescent light band, while most of the detection light cannot be transmitted.

[0098] like Fig.24 and Fig.25 As shown, the optical lens 466 is installed on the light source input port 463, the first light source detection port 461, the second light source detection port 462 and the sample detection port 464. The first filter 4671 and the second filter 4672 are installed on the light source input port 463 and the first light source detection port 461 respectively. The optical lens 466 plays a collecting role, collecting the scattered light before emitting it, which can enhance the intensity of the light and prevent some scattered light from being absorbed. The detection light emitted by the light source 473 first passes through the first filter 4671 to filter out the non-detection light, so that the wavelength of the emitted detection light is concentrated; similarly, when the fluorescence excited by the sample passes through the second filter 4672, the non-fluorescence band is filtered, which is conducive to improving the detection accuracy of the first photodetector 478.

[0099] like Fig.24 and Fig.25 As shown, a sealing element 468 is installed on the light source input port 463, the first light source detection port 461 and the second light source detection port 462, and a through hole is opened in the middle of the sealing element 468. The sealing element 468 can effectively block the external light source from entering the light path guide 46, and the through hole can ensure that the light inside the light path guide 46 passes through the light source input port 463, the first light source detection port 461 and the second light source detection port 462.

[0100] like Fig.24 and Fig.26 As shown, a connecting piece 469 with a middle portion passing through is installed on the sample detection port 464, and the connecting piece 469 protrudes from the light path guide 46. The connecting piece 469 extends close to the sample to prevent external light sources from entering the light path guide 46.

[0101] like Fig. 22 and Fig.25 As shown, a shading plate 45 is installed between the first light source detection port 461 and the first photodetector 478, and a shading screw motor 441 and a shading drive seat 442 are installed on the light path guide 46. The shading drive seat 442 cooperates with the shading screw motor 441, the shading screw motor 441 is fixed on the light path guide 46, and the shading plate 45 is fixed on the shading drive seat 442. The shading screw motor 441 is used to drive the shading plate 45 to move, so that the first light source detection port 461 is opened and closed. As an element for detecting fluorescence, the first photodetector 478 has high sensitivity, so it cannot be exposed to light for a long time, so a shading plate 45 is provided, and the shading screw motor 441 is used to drive the shading plate 45 to move. When the first photodetector 478 needs to be used, the shading plate 45 opens the first light source detection port 461, and the fluorescence can enter the first photodetector 478. When the first photodetector 478 is not needed, the shading plate 45 closes the first light source detection port 461 to protect the first photodetector 478.

[0102] Sample placing device 50:

[0103] like Figures 10 to 12 As shown, a sample placement device 50 is placed on the receiving position 261, and the sample placement device 50 includes a main body 51, a reagent placement bottle 52 and a movable suction head 53. The main body 51 is provided with a reagent placement chamber 511 and a detection chamber 512. The reagent placement chamber 511 is isolated from the detection chamber 512. The detection chamber 512 is provided with a detection opening 51211, and the wall of the detection chamber 512 is isolated from the external light source.

[0104] The reagent placement chamber 511 is used to place reagents for the reaction, and the detection chamber 512 is used to place samples to be tested. The reagents and samples are placed separately. When testing is required, the reagents and samples are extracted to the detection chamber 512 by the extraction robot 30. The wall of the detection chamber 512 isolates the external light source, so when the detection component 40 detects the sample in the detection chamber 512 through the detection opening 51211, the wall of the detection chamber 512 is not light-transmissive and is not easy to interfere with the detection result.

[0105] like Fig.26As shown, when the receiving seat 26 is located below the detection assembly 40, the sample detection port 464 is opposite to the detection opening 51211 of the detection chamber 512, and the sample detection port 464 and the detection opening 51211 are isolated from external light sources. Specifically, the joint member 469 located at the sample detection port 464 is aligned with the detection opening 51211, so that the joint member 469 and the detection opening 51211 are isolated from external light sources, thereby preventing the external light sources from affecting the detection results.

[0106] like Fig.11 As shown, the detection chamber 512 includes a detection bottle 5121 and a covering sleeve 5122, wherein the covering sleeve 5122 covers the side wall of the detection bottle 5121, and the side wall of the detection bottle 5121 isolates the external light source. The detection bottle 5121 is used to hold the sample, and the covering sleeve 5122 can isolate the external light source.

[0107] like Fig.11 As shown, two specific detection bottles 5121 are provided, and the covering sleeve 5122 covers the two detection bottles 5121. One of the two detection bottles 5121 can be used for a control group and the other for an experimental group, thereby increasing the accuracy of the detection.

[0108] The covering sleeve 5122 is made of at least one of black plastic material, black rubber or black silicone material. The covering sleeve 5122 is made of black material, which can block the external light source and complete the function of blocking the external light source. Of course, it can also be made of other color materials that can block light transmission.

[0109] In other embodiments, the detection bottle 5121 and the covering sleeve 5122 are used to isolate the external light source.

[0110] like Fig.12 and Fig.24 As shown, the covering sleeve 5122 is provided with a clamping groove 51221 surrounding the detection bottle 5121. The clamping groove 51221 contacts and cooperates with one end of the joint member 469, that is, the joint member 469 is clamped into the clamping groove 51221, so the joint member 469 and the clamping groove 51221 are not transparent. In addition, since there is an elastic force between the optical path guide 46 and the first detection drive seat 477, when the joint member 469 contacts the clamping groove 51221, it can continue to be pressed by the elastic force to ensure that the joint member 469 and the clamping groove 51221 are always in contact. Therefore, when in use, there is no need to shield the entire instrument from light, and the sample and the optical path guide 46 of the detection component 40 are detected in a shielded state. Compared with shielding the first detection drive seat 477, it is conducive to miniaturization of the equipment and greatly reduces the manufacturing cost.

[0111] like Fig.12As shown, a limiting column 51222 is disposed on the outer side of the covering sleeve 5122, and a limiting groove 513 matching the limiting column 51222 is disposed on the main body 51. The covering sleeve 5122 is installed on the main body 51, and the limiting column 51222 cooperates with the limiting groove 513 for limiting. The limiting column 51222 cooperates with the limiting groove 513 to ensure that the position of the covering sleeve 5122 is relatively controllable when it is assembled on the main body 51, so as to avoid reverse installation.

[0112] like Fig.12 As shown, a buckling protrusion 51223 is provided on the outer side of the covering sleeve 5122, and a buckling groove 514 matching the buckling protrusion 51223 is provided on the main body 51. The covering sleeve 5122 is installed on the main body 51, and the buckling protrusion 51223 is clamped on the buckling groove 514. The buckling protrusion 51223 is clamped with the buckling groove 514, so that the covering sleeve 5122 and the main body 51 are fixedly connected.

[0113] like Fig.11 As shown, the main body 51 is provided with a first placement hole 515, and the reagent placement bottle 52 is placed on the first placement hole 515. For some reagents, the preservation requirements are high or the acquisition methods are different, so a dedicated reagent placement bottle 52 is provided, and the reagent placement bottle 52 is placed separately on the first placement hole 515. The main body 51 is provided with a second placement hole 516, and the movable suction head 53 is placed on the second placement hole 516. The movable suction head 53 is used to absorb reagents and samples, and as a disposable item, each main body 51 is equipped with at least one movable suction head 53.

[0114] like Fig.10 and 11 As shown, the main body 51 is provided with a sample chamber 517, and the detection chamber 512, the reagent placement chamber 511 and the sample chamber 517 are arranged in a row. The sample chamber 517 is used to place the sample to be detected, for example, a blood sample, and then the blood sample is placed in the detection chamber 512 by the extraction manipulator 30. The detection chamber 512, the reagent placement chamber 511 and the sample chamber 517 are arranged in a row so that they are always kept in a straight line under the drive of the sample delivery component 20, which is convenient for the extraction manipulator 30 to extract.

[0115] When in use, the sample is placed on the receiving position 261 of the receiving seat 26, and the receiving seat 26 is driven by the sample delivery component 20 to be transported to the bottom of the extraction manipulator 30. At this time, the extraction manipulator 30 is used to extract the sample and extract the sample to different positions for reaction; then the sample delivery component 20 continues to drive, and the receiving seat 26 is transported to the bottom of the detection component 40, and the sample detection port 464 is used to align the sample located at the receiving position 261 that has completed the reaction, and then optical detection is performed to obtain data. The whole process does not require manual operation, and an automatic detection is realized, achieving the effect of rapid detection, which can effectively improve the efficiency of detection.

[0116] Specifically, when the extraction manipulator 30 sucks, the movable suction head 53 is first inserted into the pipette 3323, and then the movable suction head 53 is used to suck the sample out of the sample chamber 517 and suck it into the detection chamber 512; the extraction manipulator 30 continues to move, sucks the reagent in the reagent placement chamber 511 or the reagent placement bottle 52, and sucks it into the detection chamber 512. Here, the reagents are sucked one by one, and finally the sample and the reagent react in the detection chamber 512. Whether it is a sample or a reagent, there may be an excess when the extraction manipulator 30 sucks, and the excess sample or reagent is sucked back to the original placement position by the extraction manipulator 30. Of course, a cleaning liquid for cleaning can also be placed on the main body 51, and the cleaning liquid can be used to clean the movable suction head 53 after each sample or reagent is sucked.

[0117] like Figure 1 As shown, the sample delivery components 20 are provided with three groups, and the number of groups of the extraction manipulators 30 is the same as the number of groups of the sample delivery components 20, and each group of the extraction manipulators 30 corresponds to each group of the sample delivery components 20. In order to make the detection fast, the sample delivery components 20 and the extraction manipulators 30 are provided in multiple groups, and each group of the sample delivery components 20 corresponds to each group of the extraction manipulators 30. Therefore, when the first group of sample delivery components 20 performs optical detection, the second group of sample delivery components 20 can continue to extract the sample reaction under the action of the second group of manipulators, so that the time during the detection is fully utilized and the detection rate is accelerated.

[0118] The sample delivery component 20 is driven to deliver in a straight line, so the extraction robot 30 and the detection component 40 corresponding to the sample delivery component 20 are both above the delivery track of the sample delivery component 20 .

[0119] When quoting drawing descriptions, new features that appear are described; in order to avoid repeated quotations of drawings resulting in less concise descriptions, features that have been described clearly will not be quoted in the drawings one by one.

[0120] The purpose of the above embodiments is to exemplarily reproduce and deduce the technical solution of the present invention, and to fully describe the technical solution, purpose and effect of the present invention. Its purpose is to make the public understand the disclosed content of the present invention more thoroughly and comprehensively, and it does not limit the scope of protection of the present invention.

[0121] For example, three or four detection bottles 5121 may be provided;

[0122] For example, the sample delivery components 20 and the extraction manipulators 30 are provided in two or four groups;

[0123] For example, the screw motor used may be a combination of a common motor and a screw.

[0124] The above embodiments are not exhaustive enumerations of the present invention, and there may be multiple other implementations not listed. Any replacement and improvement made without violating the concept of the present invention shall fall within the protection scope of the present invention.

Claims

1. An immunoassay analyzer, characterized in that: include: A support frame, a sample delivery component, an extraction manipulator and a detection component; a sample placement device is placed on the sample delivery component, and the sample placement device includes a main body, and a reagent placement chamber and a detection chamber are arranged on the main body, and the detection chamber is provided with a detection opening, and the detection chamber includes a detection bottle and a covering sleeve, and the covering sleeve covers the side wall of the detection bottle, and the covering sleeve isolates the external light source; A limiting column is arranged on the outer side of the covering sleeve, a limiting groove matching the limiting column is arranged on the main body, the covering sleeve is installed on the main body, and the limiting column cooperates with the limiting groove for limiting; a buckling protrusion is arranged on the outer side of the covering sleeve, a buckling groove matching the buckling protrusion is arranged on the main body, and the buckling protrusion is clamped on the buckling groove; the covering sleeve is made of at least one of black plastic material, black rubber or black silicone material; the covering sleeve is provided with a clamping groove surrounding the detection bottle; The sample delivery component includes a receiving seat, a receiving position is provided on the receiving seat, the detection component is provided with a first detection drive group, a light source, a light path guide, a first photodetector and a second photodetector, the second photodetector is used to adjust the fluorescence information detected by the first photodetector, the light path guide is provided with a light source input port, a spectrometer, a sample detection port, a first light source detection port and a second light source detection port, the spectrometer has two opposite first and second action surfaces, the channel connecting the light source input port and the second light source detection port is the first light path channel, the channel connecting the sample detection port and the first light source detection port is the second light path channel two optical path channels, the first optical path channel and the second optical path channel intersect, the beam splitter is installed at the intersection of the first optical path channel and the second optical path channel, and the first action surface faces the light source input port and the sample detection port, the second action surface faces the first light source detection port and the second light source detection port, a joint member with a middle portion passing through is installed on the sample detection port, and the sample detection port corresponds to the receiving position; when the receiving seat is located below the detection component, the joint member located at the sample detection port is aligned with the detection opening of the detection bottle, so that the joint member and the detection opening block the external light source; The engaging member is inserted into the locking groove of the covering sleeve, and the space between the engaging member and the locking groove is lightproof; The first detection drive group includes a first detection drive seat, which is fixed to the optical path guide via a receiving plate, a spring is provided between the receiving plate and the first detection drive seat, and the optical path guide and the first detection drive seat are elastic, so that when the coupling member contacts the positioning groove, the coupling member can continue to be pressed by the elastic force, ensuring that the coupling member and the positioning groove are always in contact.

2. The immunoassay analyzer according to claim 1, characterized in that: It also includes a reagent placement bottle. The main body is provided with a first placement hole, and the reagent placement bottle is placed on the first placement hole.

3. The immunoassay analyzer according to claim 1, characterized in that: It also includes a movable suction head. The main body is provided with a second placement hole, and the movable suction head is placed on the second placement hole.

4. The immunoassay analyzer according to claim 1, characterized in that: The main body is provided with a sample chamber, and the detection chamber, the reagent placement chamber and the sample chamber are arranged in a row.

5. The immunoassay analyzer according to claim 1, characterized in that: The sample delivery component, the extraction robot and the detection component are all installed on the support frame.

6. The immunoassay analyzer according to claim 1, characterized in that: Two detection bottles are provided, and the covering sleeve covers the two detection bottles.

7. The immunoassay analyzer according to claim 1, characterized in that: The reagent placement chamber is isolated from the detection chamber.

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