Use of phospholipids in the regulation of angiogenesis

By using high-purity phospholipid extracts to test their effects on angiogenesis in a zebrafish model, the evaluation challenge of phospholipids in the regulation of angiogenesis was solved. The study discovered their promoting or inhibiting effects on angiogenesis in zebrafish, providing a drug candidate for the treatment of vascular diseases with broad market prospects.

CN112843072BActive Publication Date: 2026-07-10BIOLOGY INST OF SHANDONG ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BIOLOGY INST OF SHANDONG ACAD OF SCI
Filing Date
2021-01-12
Publication Date
2026-07-10

AI Technical Summary

Technical Problem

There is no existing evaluation of the bioactivity of phospholipids in angiogenesis, and the mechanism of angiogenesis is complex, making it difficult to regulate angiogenesis through phospholipids to treat related diseases.

Method used

Phospholipids were used as the active ingredient. Egg yolk phospholipid extract, soybean phospholipid extract and Litopenaeus vannamei phospholipid extract with a total phospholipid purity of greater than 80% were prepared and applied to zebrafish models to detect their effects on the growth of intersegmental vessels and inferior intestinal veins induced by the vascular endothelial growth factor receptor inhibitor PTK787.

Benefits of technology

Different phospholipids were found to regulate PTK787-induced intersegmental vascular damage in zebrafish and to promote or inhibit the growth of the inferior intestinal vein in zebrafish to varying degrees, providing a candidate drug for vascular diseases with broad market prospects.

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Abstract

The present application relates to the application of phospholipids in regulating angiogenesis, and the present application applies various phospholipids and products thereof to a zebrafish model to evaluate the influence of the phospholipids on the damage of intersegmental vessels (ISVs) induced by vascular endothelial cell growth factor receptor inhibitor (PTK787) and the growth of subintestinal vessels (SIVs) in the zebrafish, and it is found for the first time that phospholipids from different sources and in different forms can reverse the damage of ISVs induced by PTK787, significantly promote the growth of SIVs in the zebrafish, and increase the length of the generated blood vessels to different degrees, and have small toxic and side effects; the present application can provide candidates for preparing drugs for vascular diseases, and has a good application prospect.
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Citation Information

Patent Citations

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  • CN111529541A

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  • CN112315984A