A non-invasive analysis device and system for respiratory disease detection

Abstract

The present invention discloses a non-invasive analysis device for respiratory disease detection, which includes an exhalation part, a collection and analysis part, and an exhaust part; wherein the exhalation part and the exhaust part can be movably connected to the collection and analysis part, the exhalation part is used to provide an air inlet channel for the human body to exhale, the collection and analysis part collects and analyzes the exhaled gas flowing into the exhalation part and then feeds it back to the detection and analysis device, and the exhaled gas flows out to the exhaust part. By setting up a separate exhalation part, a collection and analysis part, and an exhaust part, the present invention can replace or clean the exhalation part in a timely and convenient manner, effectively reducing the workload of medical staff and increasing the convenience of operation; the independent setting of the collection and analysis part avoids secondary contact and processing of the detection target, prevents the detection target from diffusing into the external environment, and improves the accuracy and efficiency of the detection.

Description

Technical Field

[0001] The present invention relates to the technical field of in vitro diagnostic testing instruments and equipment, and in particular to a non-invasive analysis device and system for respiratory disease detection. Background Art

[0002] For diseases that require respiratory gas detection, such as chronic cough, cough variant asthma, bronchitis, and C13 and C14 breath tests in gastroenterology, it is generally necessary to detect certain components of the respiratory gas and use electrochemical methods, spectrophotometry, fluorescence methods, and ion mobility spectrometry to achieve quantitative and qualitative detection. Currently, the following two methods are generally used for the detection of diseases through respiratory gas:

[0003] The first method is to breathe directly into the instrument, that is, hold the air inlet of the detection instrument, breathe through the mouth or nose, and detect the gas content that needs to be calibrated through the reagents and systems inside the instrument, so as to determine the cause or lesion.

[0004] Another method is to first exhale the gas into a gas storage bag and then detect it through a detection instrument.

[0005] For the first detection method, although the detection accuracy and efficiency are high, the air inlet device of the detection instrument needs to be configured one-to-one, that is, one air inlet can only be used by one person to be tested to prevent cross infection, and the air inlet and airway need to be strictly disinfected. When there are many people to be tested, medical staff need to repeatedly replace the air inlet, and replace or clean and disinfect the air inlet channel, resulting in reduced detection efficiency and increased workload for medical staff.

[0006] For the second detection method, a storage bag is used to store exhaled gas, which is more convenient to use. However, there are strict requirements on the storage time limit of the gas in the storage bag. If the storage time is too long, the gas will lose its effectiveness and cannot be accurately detected. In addition, it is inconvenient to seal the bag after blowing the gas and to take the gas out of the storage bag for sampling. The gas in the bag is easy to leak out. If the gas carries bacteria, it is easy to cause infection and other problems, and the safety is low.

[0007] Based on the above problems, the present invention analyzes the characteristics of the method of using respiratory gas for detection, combines the application characteristics of modern intelligent detection instruments and equipment, and analyzes the convenience of personnel sampling operations to provide a detection device that can prevent the diffusion of respiratory gas, is easy to operate, and has high detection efficiency, thereby improving the method of respiratory gas detection. Summary of the Invention

[0008] The main purpose of the present invention is to provide a non-invasive analysis device and system for respiratory disease detection, aiming to solve the technical problems in the prior art of respiratory disease detection devices that respiratory gas is easily diffused, inconvenient to operate, and has low detection efficiency.

[0009] To achieve the above-mentioned objectives, an embodiment of the present invention proposes a non-invasive analysis device for respiratory disease detection, wherein the non-invasive analysis device includes an exhalation part, a collection and analysis part, and an exhaust part; wherein the exhalation part and the exhaust part can be movably connected to the collection and analysis part, the exhalation part is used to provide an air inlet channel for the human body to exhale, the collection and analysis part collects the exhaled gas flowing into the exhalation part and feeds it back to the detection and analysis device, and the exhaled gas flows out to the exhaust part.

[0010] In which, the collection and analysis part includes a fixed box body, a first socket, a second socket and a collection and analysis component; wherein, the first socket and the second socket are arranged on both sides of the fixed box body with their backs to each other, and the collection and analysis component is arranged inside the fixed box body and is connected to the first socket and the second socket; the exhalation part can be movably plugged in and connected to the first socket, and the exhaust part can be movably plugged in and connected to the second socket.

[0011] Wherein, the collection and analysis component includes a water absorption reaction area unit, a circuit transmission area unit and a plug output area unit; wherein,

[0012] The water absorption reaction zone unit is located on the circuit transmission zone unit, and the water absorption reaction zone unit is provided with a plurality of water absorption through holes, and the water absorption through holes are used to absorb exhaled gas of the human body;

[0013] The circuit transmission area unit is electrically connected to the plug output area unit and is used to output the reaction result of the circuit transmission area unit to the detection and analysis device.

[0014] A metal layer is provided on the hole wall of the water absorption through hole, wherein the metal layer is connected to the internal circuit layer of the circuit transmission area unit for transmitting the chemical reaction result of the water absorption reaction area unit.

[0015] Wherein, a high water absorbent resin layer is further provided on the hole wall of the water absorbing through hole, and the high water absorbent resin layer is attached to the outer surface of the metal layer and is used for absorbing gas and / or different test reagents.

[0016] Wherein, the exhalation part includes an exhalation mouthpiece, a first plug and a first diaphragm; wherein,

[0017] The first plug is movably pluggable and connected to the first socket;

[0018] The exhalation nozzle is connected to the first plug to form an air inlet channel, and the first diaphragm is arranged on the air inlet channel.

[0019] The exhalation mouthpiece is trumpet-shaped, and closely connected cracks are provided in the middle of the first diaphragm.

[0020] Wherein, the air outlet portion includes a second plug, a second diaphragm and a disinfection component; wherein,

[0021] The second plug is movably pluggable and connected to the second socket;

[0022] The second plug is connected to the disinfection component to form an air outlet channel, and the second diaphragm is arranged on the air outlet channel.

[0023] Wherein, the disinfection component includes a barrier net, a disinfection medium and a filter screen; wherein, the barrier net, the disinfection medium and the filter screen are sequentially arranged in the outlet direction of the second diaphragm.

[0024] To achieve the above-mentioned purpose, an embodiment of the present invention also proposes a non-invasive analysis system for respiratory disease detection, wherein the non-invasive analysis system includes a non-invasive analysis device and a detection and analysis device; wherein the non-invasive analysis device is the non-invasive analysis device described above, the non-invasive analysis device is electrically connected to the detection and analysis device, and the detection and analysis device receives information from the non-invasive analysis device and performs detection and analysis on the information.

[0025] Compared with the existing technology, the technical solution proposed in the present invention, by setting up separate exhalation part, collection and analysis part and air outlet part, can replace or clean the exhalation part in a timely and convenient manner, effectively reducing the workload of medical staff and increasing the convenience of operation; the independent setting of the collection and analysis part avoids secondary contact and processing of the detection target, and prevents the detection target from diffusing into the external environment. Furthermore, by setting a highly absorbent resin in the through hole of the circuit board in the collection and analysis part, it can efficiently and fully absorb the target to be detected, and adopts a method of combining with the circuit system to realize electrochemical detection, which can improve the accuracy and efficiency of detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying any creative work.

[0027] Figure 1This is a structural schematic diagram of an embodiment of a non-invasive analysis device for respiratory disease detection according to the present invention;

[0028] Figure 2 for Figure 1 Schematic diagram of the split structure of the non-invasive analysis device;

[0029] Figure 3 for Figure 1 Schematic diagram of the top view of the middle exhalation part;

[0030] Figure 4 for Figure 1 A schematic diagram of the overhead structure of the collection and analysis unit;

[0031] Figure 5 for Figure 4 A schematic diagram of the overhead structure of the collection and analysis component;

[0032] Figure 6 for Figure 5 Schematic diagram of the cross-sectional structure of AA;

[0033] Figure 7 for Figure 6 Schematic diagram of the enlarged structure of the middle B area;

[0034] Figure 8 The figure is a structural diagram of an embodiment of a non-invasive analysis system for respiratory disease detection according to the present invention.

[0035] The purpose, features and advantages of the present invention will be further described with reference to the accompanying drawings and in conjunction with the embodiments.

[0036] Description of Figure Numbers:

[0037] Label name Label name 1 Non-invasive analysis system 2410 Water absorption reaction zone unit 200 Detection and analysis device 2420 Circuit transmission area unit 100 Non-invasive analysis device 2430 Plug output area unit 10 Expiratory part 2411 Water absorption hole 20 Collection and Analysis Department 2412 Metal layer 30 Exhaust 2413 Super absorbent resin layer 110 First plug 310 Second plug 120 First diaphragm 320 Second diaphragm 130 Exhalation nozzle 330 Disinfection components 210 First socket 331 Partition net 220 Second socket 332 Disinfection medium 230 Fixed box 333 filter 240 Collection and analysis components DETAILED DESCRIPTION

[0038] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0039] It should be noted that if the embodiments of the present invention involve directional indications (such as up, down, left, right, front, back, etc.), the directional indications are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture. If the specific posture changes, the directional indications will also change accordingly.

[0040] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the present invention, the descriptions of "first", "second", etc. are only for descriptive purposes and cannot be understood as indicating or suggesting their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features limited to "first" and "second" may explicitly or implicitly include at least one of such features. In addition, if "and / or" or "and / or" appears in the full text, its meaning includes three parallel solutions. Taking "A and / or B" as an example, it includes solution A, solution B, or solutions that satisfy both A and B. In addition, the technical solutions between the various embodiments can be combined with each other, but it must be based on the ability of ordinary technicians in this field to implement. When the combination of technical solutions is mutually contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0041] In order to better understand the above technical solution, the above technical solution is described in detail below with reference to the accompanying drawings.

[0042] Please also refer to Figure 1 and Figure 2 , Figure 1 This is a structural schematic diagram of an embodiment of a non-invasive analysis device for respiratory disease detection according to the present invention; Figure 2 for Figure 1 Schematic diagram of the split structure of the non-invasive analysis device.

[0043] like Figure 1 As shown, the non-invasive analysis device 100 for respiratory disease detection includes an exhalation section 10, a collection and analysis section 20, and an outlet section 30. The exhalation section 10 and the outlet section 30 are movably connected to the collection and analysis section 20. The exhalation section 10 is used to provide an air inlet channel for the human body to exhale. The collection and analysis section 20 collects the exhaled gas flowing into the exhalation section 10 and feeds it back to the detection and analysis device. The exhaled gas flows out to the outlet section 30.

[0044] The non-invasive analysis device 100 for respiratory disease detection of this embodiment is equipped with a separate exhalation part 10, a collection and analysis part 20, and an exhaust part 30, so that the exhalation part 10 can be replaced or cleaned in a timely and convenient manner, effectively reducing the workload of medical personnel and increasing the convenience of operation; the independent setting of the collection and analysis part 20 avoids secondary contact and processing of the detection target, prevents the detection target from spreading to the external environment, and at the same time improves the accuracy and efficiency of the detection.

[0045] See also Figure 2The collection and analysis unit 20 includes a fixed housing 230, a first socket 210, a second socket 220, and a collection and analysis assembly 240. The first socket 210 and the second socket 220 are disposed on opposite sides of the fixed housing 230. The collection and analysis assembly 240 is disposed within the fixed housing 230 and communicates with the first socket 210 and the second socket 220. The exhalation unit 10 is removably connected to the first socket 210, and the exhaust unit 30 is removably connected to the second socket 220.

[0046] Furthermore, the exhalation portion 10 in this embodiment includes an exhalation nozzle 130, a first plug 110 and a first diaphragm 120; wherein the first plug 110 is movably pluggable and connected to the first socket 210; the exhalation nozzle 130 is connected to the first plug 110 to form an air intake channel, and the first diaphragm 120 is arranged on the air intake channel.

[0047] In practical applications, the exhalation nozzle 130 is shaped like a trumpet, wide at the top and narrow at the bottom. The wide portion at the top is designed to wrap around the nose and mouth of the person, thereby receiving the exhaled gas to be tested. The first diaphragm 120 is positioned on the air inlet channel formed by the connection between the exhalation nozzle 130 and the first plug 110. Specifically, the first diaphragm 120 can be positioned at the connection between the exhalation nozzle 130 and the first plug 110, or in the middle of the first plug 110. The middle portion of the first diaphragm 120 is provided with a closely connected crack. When the person exhales, the gas expands the crack, allowing the exhaled gas to pass through the first diaphragm 120. After exhalation is completed, the crack closes, effectively preventing the exhaled gas from escaping. The exhalation nozzle 130 can be made of a soft or hard material; soft materials include rubber, silicone, plastic, etc., while hard materials include plastic, etc.; preferably, a soft rubber material is used. The first diaphragm 120 is made of a soft, resilient material, such as rubber, silicone, or polyimide. In this embodiment, the exhalation nozzle 130 and the first plug 110 are integrally formed. In other embodiments, the exhalation nozzle 130 , the first plug 110 and the first diaphragm 120 can be integrally formed or manufactured in separate steps, which is not limited here.

[0048] Furthermore, the air outlet portion 30 in this embodiment includes a second plug 310, a second diaphragm 320 and a disinfection component 330; wherein, the second plug 310 can be movably plugged and unplugged and connected to the second socket 220; the second plug 310 is connected to the disinfection component 330 to form an air outlet channel, and the second diaphragm 320 is arranged on the air outlet channel.

[0049] The disinfection assembly 330 includes a baffle 331 , a disinfection medium 332 and a filter 333 . The baffle 331 , the disinfection medium 332 and the filter 333 are sequentially arranged in the outlet direction of the second diaphragm 320 .

[0050] In specific practical applications, the baffle net 331 and the filter screen 333 can be made of the same material, wherein the mesh density of the baffle net 331 is smaller than the mesh density of the filter screen 333, and the disinfection medium 332 is a carrier containing disinfection material, which is arranged between the baffle net 331 and the filter screen 333. The baffle net 331, the disinfection medium 332 and the filter screen 333 are combined to form a disinfection component, which is arranged at the air outlet of the air outlet part 30. Among them, the second diaphragm 320 is consistent with the material and design of the first diaphragm 120, made of soft and resilient material, and has a tightly connected crack in the middle, which is arranged on the air outlet channel formed by the connection between the second plug 310 and the disinfection component 330. Among them, the material and design of the first plug 110 and the second plug 310 are also consistent.

[0051] In summary, the collection and analysis unit 20 includes a fixed box body 230, a first socket 210, a second socket 220, and a collection and analysis component 240. The first socket 210 and the second socket 220 are arranged on opposite sides of the fixed box body 230, and the collection and analysis component 240 is arranged inside the fixed box body 230 and is connected to the first socket 210 and the second socket 220. Specifically, the collection and analysis component 240 is fixed to the inside of the fixed box body 230 by bolts and is sealed to ensure the effectiveness of the collection and analysis component 240; the first plug 110 is movably pluggable and connected to the first socket 210, and the second plug 310 is movably pluggable and connected to the second socket 220. In this embodiment, a sealing rubber ring, such as a plastic ring, a silicone ring, a rubber ring, etc., can be designed at the first socket 210 and the second socket 220 to facilitate the first plug 110 and the second plug 310 to be tightly combined and well sealed when inserted. In other embodiments, it can also be a snap-on or screw-on type (when both the socket and the plug are round) for easy disassembly. Therefore, after the entire exhalation portion 10 and the air outlet portion 30 are inserted into the collection and analysis portion 20, the entire gas channel forms a sealed area.

[0052] Optionally, the fixed box body 230 is used to fix the collection and analysis component 240, supporting the collection and analysis component 240, and providing a protective structure for the overall non-invasive analysis device 100 that is easy to hold, place, and store. The fixed box body 230 does not participate in the analysis, detection, and gas and / or liquid collection process.

[0053] Please also refer to Figures 4 to 7The collection and analysis component 240 includes a water absorption reaction area unit 2410, a circuit transmission area unit 2420 and a plug output area unit 2430; wherein, the water absorption reaction area unit 2410 is located on the circuit transmission area unit 2420, and the water absorption reaction area unit 2410 is provided with a plurality of water absorption through holes 2411, which are used to absorb the exhaled gas of the human body; the circuit transmission area unit 2420 and the plug output area unit 2430 are electrically connected to output the reaction results of the circuit transmission area unit 2420 to the detection and analysis device.

[0054] A metal layer 2412 is formed on the wall of the water absorption through-hole 2411. This metal layer 2412 is connected to the internal circuit layer of the circuit transmission section 2420. This metal layer 2412 transmits the chemical reaction results from the water absorption reaction section 2410. The internal circuit layer outputs the chemical reaction results to the plug output section 2430, which then transmits them to an external detection and analysis device. Specifically, the plug area of ​​the plug output section 2430 is a gold finger plug, which offers excellent oxidation resistance, conductivity, and wear resistance, allowing for repeated plugging and unplugging.

[0055] Optionally, the inner circuit layer is connected to the plug output area unit 2430 through a blind hole.

[0056] In this embodiment, a superabsorbent resin layer 2413 is also provided on the wall of the water-absorbing through-hole 2411. This superabsorbent resin layer 2413 is attached to the outer surface of the metal layer 2412 and is used to adsorb gas and / or various test reagents. The adsorbed gas refers to exhaled gas, including both gas and water vapor in exhaled breath. The design of the water-absorbing through-hole 2411 ensures that exhaled gas effectively passes through the superabsorbent resin layer 2413, forming effective contact and adsorption with the superabsorbent resin layer 2413. Furthermore, it increases the contact area between the gas and the superabsorbent resin layer 2413, thereby improving the superabsorbent resin's water absorption efficiency. Among them, the metal layer 2412 can be a metallic copper layer, that is, the super absorbent resin layer 2413 is attached to the copper layer 2412 in the hole. Since the super absorbent resin layer effectively retains the test sample and has a large contact area with the copper layer in the hole of the circuit board, that is, the test sample can have a large area of ​​connection with the metal layer circuit of the collection and analysis component, the super absorbent resin layer 2413 is provided on the hole wall of the water absorption through hole 2411, which can absorb and detect the test sample and form an effective testing and analysis environment. Therefore, the super absorbent resin layer 2413 is attached to the copper layer 2412 in the hole wall, forming a large water absorption area and a large contact area with the copper layer in the hole wall, thereby forming a strong and efficient connection with the internal circuit layer and the plug part. Among them, the super absorbent resin layer 2413 in the hole wall is completed through a resin plugging process, a drying process, and a drilling process. Its specific production method refers to the existing resin plugging process and is not repeated here.

[0057] Optionally, the through hole has a diameter of 1.5 mm to 3.0 mm. After the through hole is filled with super absorbent resin and dried, it is drilled using a 0.2 mm to 2.0 mm drill bit to form a 0.2 mm to 2.0 mm hole, which is the water absorption hole, and the remaining super absorbent resin layer 2413 attached to the copper layer 2412 in the hole is ensured to have a thickness of 0.2 mm to 2.8 mm.

[0058] The main component of the highly absorbent resin layer 2413 is sodium polyacrylate or starch grafted acrylic acid or cellulose grafted acrylic acid, and the auxiliary components include fillers, diluents, anti-skinning agents, dispersants, defoaming agents, etc.

[0059] The water absorption capacity of the super absorbent resin layer can reach 100 to 1000 times its own weight, and the water absorption rate can reach 5 to 10 seconds. The performance can ensure that the exhaled water vapor is quickly and fully absorbed, or the gas components to be tested after the detection solution is dripped in can be quickly and fully absorbed.

[0060] In practical applications, gas analysis can be performed. Before detecting respiratory diseases, medical staff drip corresponding detection reagents or detection potions into the super absorbent resin area or super absorbent resin layer. For example, to detect the nitric oxide (or carbon dioxide) content in the human body, the corresponding detection reagents or potions for detecting the nitric oxide (or carbon dioxide) content are dripped into the human body. The human body then exhales, and the exhaled gas is absorbed by the super absorbent resin containing the detection potion. In other embodiments, body fluid analysis can also be performed, for example, blood is directly dripped into the super absorbent resin area for various content tests.

[0061] Method of use 1: Install the exhalation part 10 and the exhaust part 30. The person to be tested exhales directly through the exhalation part 10. The water vapor in the gas is absorbed by the water absorption area unit, and the excess gas is discharged through the exhaust part 30. Insert the non-invasive analysis device into the detection equipment to detect the content of simple gas or water vapor content, so as to detect the breathing condition of the person to be tested or determine the lesion.

[0062] Method 2: First, install the air outlet section 30, then drip the test solution to be tested into the water absorption area, and then install the exhalation section 10. The solution is absorbed by the super absorbent resin. Then, exhale through the exhalation section. The components to be tested in the gas are absorbed by the super absorbent resin. The components to be tested in the gas react with the test solution, and the reaction process generates electrons. The device is inserted into the detection instrument, and the breathing condition of the person to be tested or the lesion is determined based on the content of the generated electrons.

[0063] Method three of use is to perform body fluid testing. The exhalation portion 10 is not installed first, but only the exhaust portion 30 is installed. A test solution of the body fluid to be tested is dropped onto the water absorption area. The solution is absorbed by the highly absorbent resin, and then the body fluid to be tested, specifically blood, is dropped into the test solution. The components to be tested in the body fluid react with the solution, and the reaction process generates electrons. The device is then inserted into a detection instrument, and the breathing condition of the person to be tested is detected or the lesion is determined based on the content of the generated electrons.

[0064] Among them, the metal layer transmits the electrons generated during the reaction and plays a role in conductive transmission.

[0065] Furthermore, the water absorption reaction zone unit 2410 is reusable. The method for reuse is as follows: disinfect the superabsorbent resin area (using alcohol or other methods) → remove the entire circuit board → bake it (150°C for 30 minutes) → disinfect it again → bake it again (150°C for 30-60 minutes) → reassemble it. The total number of reuses is no more than three. The superabsorbent resin area of ​​the water absorption reaction zone unit 2410 is highly versatile and facilitates convenient and efficient operation by medical personnel.

[0066] The collection assembly 240 of this embodiment is provided with a water absorption reaction zone unit 2410 and a super absorbent resin layer 2413 disposed on the water absorption reaction zone unit 2410. The super absorbent resin layer 2413 can increase the contact area with the copper layer of the hole wall, thereby increasing the efficiency of the test reagent and the test sample. In addition, the super absorbent resin layer 2413 can detect test samples of different reagents and has strong versatility.

[0067] See also Figure 8 , Figure 8 The figure is a structural diagram of an embodiment of a non-invasive analysis system for respiratory disease detection according to the present invention.

[0068] like Figure 8 As shown, the noninvasive analysis system 1 for respiratory disease detection includes a noninvasive analysis device 100 and a detection and analysis device 200. The noninvasive analysis device 100 is electrically connected to the detection and analysis device 200, which receives information from the noninvasive analysis device and performs detection and analysis on the information. The noninvasive analysis device 100 is the same as that of the aforementioned embodiment, and its structure is described above and will not be further described.

[0069] In this embodiment, the detection and analysis device 200 further includes a slot unit for inserting the plug output area unit 2430 of the non-invasive analysis device 100 to achieve electrical connection.

[0070] The detection and analysis device 200 can be further divided into a receiving and analyzing unit and a result feedback unit, wherein the receiving and analyzing unit and the result feedback unit can be an integrated device or can be split into two separate devices, which is not limited here.

[0071] In summary, it is easy for those skilled in the art to understand that in the technical solution proposed by the present invention, by setting up separate exhalation parts, collection and analysis parts and air outlet parts, the exhalation part can be replaced or cleaned in a timely and convenient manner, effectively reducing the workload of medical staff and increasing the convenience of operation; the independent setting of the collection and analysis part avoids secondary contact and processing of the detection target, and prevents the detection target from diffusing into the external environment. Furthermore, by setting a highly absorbent resin in the through hole of the circuit board in the collection and analysis part, it can efficiently and fully absorb the target to be detected, and adopts a method of combining with the circuit system to realize electrochemical detection, which can improve the accuracy and efficiency of detection.

[0072] The above description is only a preferred embodiment of the present invention and does not limit the patent scope of the embodiment of the present invention. Any equivalent structural transformation made by using the contents of the description and drawings of the embodiment of the present invention under the inventive concept of the embodiment of the present invention, or directly / indirectly applied in other related technical fields, is included in the patent protection scope of the embodiment of the present invention.

Claims

1. A non-invasive analysis device for respiratory disease detection, characterized in that: The non-invasive analysis device comprises an exhalation part, a collection and analysis part and an exhaust part; wherein, The exhalation part and the outlet part can be movably connected to the collection and analysis part, the exhalation part is used to provide an air inlet channel for the human body to exhale, the collection and analysis part collects the exhaled gas flowing into the exhalation part and then feeds it back to the detection and analysis device, and the exhaled gas flows out to the outlet part; The collection and analysis part includes a fixed box body, a first socket, a second socket and a collection and analysis component, and the collection and analysis component includes a water absorption reaction area unit, a circuit transmission area unit and a plug output area unit; The water absorption reaction zone unit is located on the circuit transmission zone unit, and the water absorption reaction zone unit is provided with a plurality of water absorption through holes, and the water absorption through holes are used to absorb the exhaled gas of the human body; The circuit transmission area unit is electrically connected to the plug output area unit, and is used to output the reaction result of the circuit transmission area unit to the detection and analysis device; A metal layer is provided on the hole wall of the water absorption through hole, wherein the metal layer is connected to the internal circuit layer of the circuit transmission area unit, and is used to transmit the chemical reaction result of the water absorption reaction area unit; A high water absorbent resin layer is also provided on the hole wall of the water absorbing through hole. The high water absorbent resin layer is attached to the outer surface of the metal layer and is used for absorbing gas and / or different test reagents.

2. The non-invasive analysis device according to claim 1, characterized in that: The first socket and the second socket are arranged on two sides of the fixed box body facing each other, and the collection and analysis component is arranged inside the fixed box body and communicated with the first socket and the second socket; The exhalation portion is movably connected to the first socket by plugging and unplugging, and the air outlet portion is movably connected to the second socket by plugging and unplugging.

3. The non-invasive analysis device according to claim 2, characterized in that: The exhalation part includes an exhalation nozzle, a first plug and a first diaphragm; wherein, The first plug is movably pluggable and connected to the first socket; The exhalation nozzle is connected to the first plug to form an air intake passage, and the first diaphragm is arranged on the air intake passage.

4. The non-invasive analysis device according to claim 3, characterized in that: The exhalation mouthpiece is trumpet-shaped, and the middle part of the first diaphragm is provided with closely connected cracks.

5. The non-invasive analysis device according to claim 2, characterized in that: The air outlet portion includes a second plug, a second diaphragm and a disinfection component; wherein, The second plug is movably pluggable and connected to the second socket; The second plug is connected to the disinfection component to form an air outlet channel, and the second diaphragm is arranged on the air outlet channel.

6. The non-invasive analysis device according to claim 5, characterized in that: The disinfection assembly includes a barrier net, a disinfection medium and a filter screen; wherein the barrier net, the disinfection medium and the filter screen are sequentially arranged in the outlet direction of the second diaphragm.

7. A non-invasive analysis system for respiratory disease detection, characterized in that: The non-invasive analysis system includes a non-invasive analysis device and a detection and analysis device; wherein the non-invasive analysis device is the non-invasive analysis device described in any one of claims 1 to 6, the non-invasive analysis device is electrically connected to the detection and analysis device, and the detection and analysis device receives information from the non-invasive analysis device and performs detection and analysis on the information.

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