Pulse generation circuit for outputting bipolar pulses, and method and device thereof

Abstract

An embodiment of the present application provides a pulse generation circuit for outputting bipolar pulses, and a method and device thereof. The pulse generation circuit for outputting bipolar pulses includes: a first charge and discharge unit and a second charge and discharge unit; the first charge and discharge unit and the second charge and discharge unit are configured to, in a pulse generation mode, form a pulse generation loop with a load to output a designed pulse signal to the load; the designed pulse signal includes at least one of the following: a first-polarity pulse signal, a second-polarity pulse signal, a first-polarity stepped amplitude pulse signal, and a second-polarity stepped amplitude pulse signal. Embodiments of the present application can output a designed pulse signal according to requirements, avoid or reduce muscle contraction, thereby avoiding the problem of electrode needle displacement, and further can precisely control the ablation area and improve the ablation effect.

Description

Technical Field

[0001] The present application relates to the technical field of pulse generating devices. Specifically, the present application relates to a pulse generating circuit for outputting bipolar pulses, and a method and device therefor. Background Art

[0002] Irreversible electroporation (IRE) technology is to form multiple nanoscale irreversible pores on the cell membrane surface by releasing high-voltage electrical pulses, disrupting cell homeostasis, promoting apoptosis of cells, and the cell debris after apoptosis will be phagocytosed by phagocytes in the body. At the same time, the body's immune response occurs, so as to achieve the effect of controlling tumors. The key problem of the known irreversible electroporation method is the occurrence of muscle contraction caused by the current flowing through muscle tissue.

[0003] The pulse signals output by the existing pulse generating circuits are relatively single. However, there are differences in the tolerance of different patients. Using a single pulse signal is likely to cause muscle contraction, increasing the pain of patients in clinical treatment and easily causing the displacement of electrode needles, resulting in inaccurate control of the ablation area and poor ablation effect. Summary of the Invention

[0004] In view of the shortcomings of the existing methods, the present application proposes a pulse generating circuit for outputting bipolar pulses, and a method and device therefor, to solve the technical problem of poor ablation effect caused by the relatively single pulse signals output by the pulse generating circuit in the prior art.

[0005] In a first aspect, an embodiment of the present application provides a pulse generating circuit for outputting bipolar pulses, including: a first charge-discharge unit and a second charge-discharge unit;

[0006] The first charge-discharge unit is used to be electrically connected to the first power supply unit and the first end of the load, and the second charge-discharge unit is used to be electrically connected to the second power supply unit and the second end of the load;

[0007] The first charge-discharge unit and the second charge-discharge unit are configured to, in the charging mode, the first charge-discharge unit is electrically connected to the first power supply unit, and the second charge-discharge unit is electrically connected to the second power supply unit; in the pulse generating mode, the first charge-discharge unit and the second charge-discharge unit form a pulse generating loop with the load to output a designed pulse signal to the load; the designed pulse signal is at least one of the following: a first-polarity pulse signal, a second-polarity pulse signal, a first-polarity stepped amplitude pulse signal, and a second-polarity stepped amplitude pulse signal.

[0008] In a possible implementation manner, the first charge-discharge unit includes at least one first charge-discharge module and at least one second charge-discharge module;

[0009] The first power supply unit includes a first power supply and a second power supply; the voltage of the first power supply is less than the voltage of the second power supply;

[0010] Each first charge-discharge module is electrically connected in sequence and is respectively used to be electrically connected to the first power supply;

[0011] Each second charge-discharge module is electrically connected in sequence and is respectively used to be electrically connected to the second power supply;

[0012] The last first charge-discharge module and the first second charge-discharge module are electrically connected.

[0013] In a possible implementation, the first end and the second end of the first first charge-discharge module are respectively electrically connected to the positive electrode and the negative electrode of the first power supply;

[0014] Among any two adjacent first charge-discharge modules, the first end of the latter first charge-discharge module is electrically connected to the first end of the former first charge-discharge module, and the second end of the latter first charge-discharge module is electrically connected to the third end of the former first charge-discharge module; the third end of the last first charge-discharge module is electrically connected to the second end of the first second charge-discharge module;

[0015] The first end and the second end of the first second charge-discharge module are respectively electrically connected to the positive electrode and the negative electrode of the second power supply;

[0016] Among any two adjacent second charge-discharge modules, the first end of the latter second charge-discharge module is electrically connected to the first end of the former second charge-discharge module, and the second end of the latter second charge-discharge module is electrically connected to the third end of the former second charge-discharge module; the third end of the last second charge-discharge module is electrically connected to the first end of the load.

[0017] In a possible implementation, the first charge-discharge module includes a first energy storage device, a first switching device, and a second switching device;

[0018] The first end of the first energy storage device and the second end of the second switching device together serve as the first end of the first charge-discharge module;

[0019] The second end of the first energy storage device and the first end of the first switching device together serve as the second end of the first charge-discharge module;

[0020] The second end of the first switching device and the first end of the second switching device together serve as the third end of the first charge-discharge module;

[0021] The control ends of the first switching device and the second switching device are both used to be electrically connected to the control unit.

[0022] In a possible implementation, the second charge-discharge module includes a second energy storage device, a third switching device, and a fourth switching device;

[0023] The first end of the second energy storage device and the second end of the fourth switching device together serve as the first end of the second charge and discharge module;

[0024] The second end of the second energy storage device and the first end of the third switching device together serve as the second end of the second charge and discharge module;

[0025] The second end of the third switching device and the first end of the fourth switching device together serve as the third end of the second charge and discharge module;

[0026] The control ends of the third switching device and the fourth switching device are both used to be electrically connected to the control unit.

[0027] In a possible implementation, the second charge and discharge unit includes at least one third charge and discharge module and at least one fourth charge and discharge module;

[0028] The second power supply unit includes a third power supply and a fourth power supply; the voltage of the third power supply is less than the voltage of the fourth power supply;

[0029] Each third charge and discharge module is electrically connected in sequence and is respectively used to be electrically connected to the third power supply;

[0030] Each fourth charge and discharge module is electrically connected in sequence and is respectively used to be electrically connected to the fourth power supply;

[0031] The last third charge and discharge module and the first fourth charge and discharge module are electrically connected.

[0032] In a possible implementation, the first end and the second end of the first third charge and discharge module are respectively electrically connected to the positive electrode and the negative electrode of the third power supply;

[0033] Among any two adjacent third charge and discharge modules, the first end of the latter third charge and discharge module is electrically connected to the first end of the former third charge and discharge module, the second end of the latter third charge and discharge module is electrically connected to the third end of the former third charge and discharge module, and the third end of the last third charge and discharge module is electrically connected to the second end of the first fourth charge and discharge module;

[0034] The first end and the second end of the first fourth charge and discharge module are respectively electrically connected to the positive electrode and the negative electrode of the fourth power supply;

[0035] Among any two adjacent fourth charge and discharge modules, the first end of the latter fourth charge and discharge module is electrically connected to the first end of the former fourth charge and discharge module, the second end of the latter fourth charge and discharge module is electrically connected to the third end of the former fourth charge and discharge module, and the third end of the last fourth charge and discharge module is electrically connected to the second end of the load.

[0036] In a possible implementation, the third charge and discharge module includes a third energy storage device, a fifth switching device, and a sixth switching device;

[0037] The first end of the third energy storage device and the second end of the sixth switching device together serve as the first end of the third charge-discharge module;

[0038] The second end of the third energy storage device and the first end of the fifth switching device together serve as the second end of the third charge-discharge module;

[0039] The second end of the fifth switching device and the first end of the sixth switching device together serve as the third end of the third charge-discharge module;

[0040] The control terminals of the fifth switching device and the sixth switching device are both used to be electrically connected to the control unit.

[0041] In a possible implementation, the fourth charge-discharge module includes a fourth energy storage device, a seventh switching device, and an eighth switching device;

[0042] The first end of the fourth energy storage device and the second end of the eighth switching device together serve as the first end of the fourth charge-discharge module;

[0043] The second end of the fourth energy storage device and the first end of the seventh switching device together serve as the second end of the fourth charge-discharge module;

[0044] The second end of the seventh switching device and the first end of the eighth switching device together serve as the third end of the fourth charge-discharge module;

[0045] The control terminals of the seventh switching device and the eighth switching device are both used to be electrically connected to the control unit.

[0046] In a second aspect, an embodiment of the present application provides a pulse generating device for outputting bipolar pulses, including: a control unit and a pulse generating circuit for outputting bipolar pulses as in the first aspect;

[0047] The control unit is electrically connected to both the first charge-discharge unit and the second charge-discharge unit, and is used to, in the charging mode, control the first charge-discharge unit to be electrically connected to the first power supply unit and the second charge-discharge unit to be electrically connected to the second power supply unit; in the pulse generating mode, control the first charge-discharge unit and the second charge-discharge unit to form a pulse generating loop with the load to output a designed pulse signal to the load; the designed pulse signal includes at least one of the following: a first-polarity pulse signal, a second-polarity pulse signal, a first-polarity stepped amplitude pulse signal, and a second-polarity stepped amplitude pulse signal.

[0048] In a possible implementation, the pulse generating device for outputting bipolar pulses further includes: a first power supply unit and a second power supply unit;

[0049] The first power supply unit is electrically connected to the first charge-discharge unit;

[0050] The second power supply unit is electrically connected to the second charge and discharge unit.

[0051] In a third aspect, an embodiment of the present application provides a pulse generation method, which is applied to a pulse generation circuit for outputting bipolar pulses as in the first aspect, and includes:

[0052] In the charging mode, control the first charge and discharge unit to be electrically connected to the first power supply unit, and the second charge and discharge unit to be electrically connected to the second power supply unit;

[0053] In the pulse generation mode, control the first charge and discharge unit and the second charge and discharge unit to form a pulse generation loop with the load, so as to output a designed pulse signal to the load; the designed pulse signal is at least one of the following: a first-polarity pulse signal, a second-polarity pulse signal, a first-polarity stepped amplitude pulse signal, and a second-polarity stepped amplitude pulse signal.

[0054] In a possible implementation, controlling the first charge and discharge unit and the second charge and discharge unit to form a pulse generation loop with the load to output a designed pulse signal to the load includes:

[0055] Control some devices in the first charge and discharge module and the second charge and discharge module of the first charge and discharge unit to be connected in series, and some devices in the third charge and discharge module and the fourth charge and discharge module of the second charge and discharge unit to be connected in series, to form a pulse generation loop with the load. The pulse generation loop includes at least one energy storage device in the first charge and discharge unit and / or at least one energy storage device in the second charge and discharge unit.

[0056] In a possible implementation, controlling some devices in the first charge and discharge module and the second charge and discharge module of the first charge and discharge unit to be connected in series, and some devices in the third charge and discharge module and the fourth charge and discharge module of the second charge and discharge unit to be connected in series, to form a pulse generation loop with the load includes:

[0057] Control that in the first charge and discharge module, the second charge and discharge module, the third charge and discharge module, and the fourth charge and discharge module, one switching device is disconnected and the other switching device is turned on, to form a pulse generation loop with the load.

[0058] In a possible implementation, controlling that in the first charge and discharge module, the second charge and discharge module, the third charge and discharge module, and the fourth charge and discharge module, one switching device is disconnected and the other switching device is turned on, to form a pulse generation loop with the load includes:

[0059] Control that in the first charge and discharge module, the second charge and discharge module, the third charge and discharge module, and the fourth charge and discharge module, the energy storage devices of one charge and discharge module are all in the pulse generation loop, and the energy storage devices of the remaining charge and discharge modules are not in the pulse generation loop, so as to output a first-polarity pulse signal and / or a second-polarity pulse signal with at least one voltage amplitude to the load.

[0060] In a possible implementation, in the first charge-discharge module, the second charge-discharge module, the third charge-discharge module, and the fourth charge-discharge module, one switching device is turned off and the other switching device is turned on to form a pulse generation circuit with the load, including:

[0061] In the first charge-discharge module, the second charge-discharge module, the third charge-discharge module, and the fourth charge-discharge module, the number of energy storage devices of one charge-discharge module in the pulse generation circuit increases or decreases sequentially according to a predetermined time, and the energy storage devices of the remaining charge-discharge modules are not in the pulse generation circuit, so as to output a first-polarity stepped amplitude pulse signal and / or a second-polarity stepped amplitude pulse signal to the load.

[0062] The beneficial technical effects brought by the technical solution provided by the embodiments of the present application include:

[0063] The pulse generation circuit for outputting bipolar pulses according to the embodiments of the present application includes a first charge-discharge unit and a second charge-discharge unit. The first charge-discharge unit and the second charge-discharge unit are respectively used to be electrically connected to the first end and the second end of the load, so that two-polarity pulse signals, namely a first-polarity pulse signal and a second-polarity pulse signal, can be output to the load in the pulse generation mode. At the same time, the first charge-discharge unit of the embodiments of the present application is used to be electrically connected to the first power supply unit, and the second charge-discharge unit is used to be electrically connected to the second power supply unit to charge the first charge-discharge unit and the second charge-discharge unit respectively, so that in the pulse generation mode, a first-polarity stepped amplitude pulse signal and a second-polarity stepped amplitude pulse signal can be output to the load. Therefore, the pulse generation circuit for outputting bipolar pulses according to the embodiments of the present application can output designed pulse signals according to requirements, avoid or reduce muscle contraction, thereby avoiding the problem of electrode needle displacement, reducing the discomfort of the patient's body, and further accurately controlling the ablation area and improving the ablation effect.

[0064] Additional aspects and advantages of the present application will be given in part in the following description, and these will become obvious from the following description, or can be understood through the practice of the present application. Description of the Drawings

[0065] The above and / or additional aspects and advantages of the present application will become obvious and easy to understand from the following description of the embodiments in conjunction with the drawings, where:

[0066] Figure 1 is a schematic framework diagram of the electrical connection of a pulse generation circuit for outputting bipolar pulses provided by the embodiments of the present application, the first power supply unit, the second power supply unit, and the load;

[0067] Figure 2Schematic diagram of the electrical connection of another pulse generation circuit for outputting bipolar pulses provided by an embodiment of the present application to a first power supply unit, a second power supply unit, and a mentioned load;

[0068] Figure 3 Circuit structure diagram of the electrical connection of yet another pulse generation circuit for outputting bipolar pulses provided by an embodiment of the present application to a first power supply unit, a second power supply unit, and a mentioned load;

[0069] Figure 4 Schematic diagram of a pulse generation device for outputting bipolar pulses provided by an embodiment of the present application;

[0070] Figure 5 Schematic diagram of the process flow of a pulse generation method provided by an embodiment of the present application;

[0071] Figure 6 For Figure 3 Schematic diagram of the structure of the charging circuit in the charging mode of the shown circuit structure, where some switching devices are conducting and some are off. For the convenience of understanding the charging process, the conducting switching devices are retained in the figure, and the off switching devices are not shown in the figure.

[0072] Figure 7 For Figure 3 Schematic diagram of the structure of the pulse generation loop for outputting a positive low-voltage pulse signal in the pulse generation mode of the shown circuit structure.

[0073] Figure 8 For Figure 3 Schematic diagram of the structure of the pulse generation loop for outputting a negative low-voltage pulse signal in the pulse generation mode of the shown circuit structure.

[0074] Figure 9 For Figure 3 Schematic diagram of the structure of the pulse generation loop for outputting a positive high-voltage pulse signal in the pulse generation mode of the shown circuit structure.

[0075] Figure 10 For Figure 3 Schematic diagram of the structure of the pulse generation loop for outputting a negative high-voltage pulse signal in the pulse generation mode of the shown circuit structure.

[0076] Figure 11 For Figure 3 Timing diagram of the output rectangular pulse signal in the pulse generation mode of the shown circuit structure.

[0077] Figure 12 For Figure 3 Timing diagram of the output stepped high-voltage pulse signal in the pulse generation mode of the shown circuit structure.

[0078] Figure 13For Figure 3 the circuit structure shown in the timing diagram of the stepped low-voltage pulse signal output in the pulse generation mode.

[0079] Reference numerals:

[0080] 100 - Pulse generation circuit for outputting bipolar pulses

[0081] 110 - First charge and discharge unit, 111 - First charge and discharge module, 112 - Second charge and discharge module;

[0082] 120 - Second charge and discharge unit, 121 - Third charge and discharge module, 122 - Fourth charge and discharge module;

[0083] 200 - First power supply unit, 210 - First power supply, 220 - Second power supply;

[0084] 300 - Second power supply unit, 310 - Third power supply, 320 - Fourth power supply;

[0085] 400 - Load;

[0086] 500 - Control unit;

[0087] 11 - First end of the first first charge and discharge module, 12 - Second end of the first first charge and discharge module, 13 - Third end of the first first charge and discharge module, 21 - First end of the middle first charge and discharge module, 22 - Second end of the middle first charge and discharge module, 23 - Third end of the middle first charge and discharge module, 31 - First end of the last first charge and discharge module, 32 - Second end of the last first charge and discharge module, 33 - Third end of the last first charge and discharge module;

[0088] 41 - First end of the first second charge and discharge module, 42 - Second end of the first second charge and discharge module, 43 - Third end of the first second charge and discharge module, 51 - First end of the middle second charge and discharge module, 52 - Second end of the middle second charge and discharge module, 53 - Third end of the middle second charge and discharge module, 61 - First end of the last second charge and discharge module, 62 - Second end of the last second charge and discharge module, 63 - Third end of the last second charge and discharge module;

[0089] 71 - First end of the first third charge and discharge module, 72 - Second end of the first third charge and discharge module, 73 - Third end of the first third charge and discharge module, 81 - First end of the middle third charge and discharge module, 82 - Second end of the middle third charge and discharge module, 83 - Third end of the middle third charge and discharge module, 91 - First end of the last third charge and discharge module, 92 - Second end of the last third charge and discharge module, 93 - Third end of the last third charge and discharge module;

[0090] 101 - The first end of the first fourth charge-discharge module, 102 - The second end of the first fourth charge-discharge module, 103 - The third end of the first fourth charge-discharge module, 1101 - The first end of the intermediate fourth charge-discharge module, 1102 - The second end of the intermediate fourth charge-discharge module, 1103 - The third end of the intermediate fourth charge-discharge module, 1201 - The first end of the last fourth charge-discharge module, 1202 - The second end of the last fourth charge-discharge module, 1203 - The third end of the last fourth charge-discharge module. Detailed implementation manners

[0091] The present application will be described in detail below. Examples of embodiments of the present application are shown in the drawings, where the same or similar reference numerals denote the same or similar components or components having the same or similar functions throughout. In addition, if the detailed description of the known art is unnecessary for showing the features of the present application, it will be omitted. The embodiments described below with reference to the drawings are exemplary and are only used to explain the present application and should not be construed as limiting the present application.

[0092] Those skilled in the art of the present technology can understand that, unless otherwise defined, all terms (including technical terms and scientific terms) used herein have the same meaning as the general understanding of those of ordinary skill in the art to which the present application belongs. It should also be understood that terms such as those defined in a general dictionary should be understood to have a meaning consistent with the meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless specifically defined as here.

[0093] Those skilled in the art of the present technology can understand that, unless specifically stated, the singular forms "a", "an", "the" and "said" used herein may also include the plural forms. It should be further understood that the phrase "comprising" used in the specification of the present application means the presence of the stated features, integers, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components and / or their groups. It should be understood that when we say that an element is "connected" or "coupled" to another element, it can be directly connected or coupled to other elements, or there may also be intermediate elements. In addition, the "connection" or "coupling" used herein may include wireless connection or wireless coupling. The phrase "and / or" used herein includes all or any unit and all combinations of one or more related listed items.

[0094] The inventors of the present application conducted research and found that in animal experiments and cell experiments, it was shown that the amplitude of the electric pulse field strength is proportional to the degree of cell membrane perforation. If too high an amplitude and pulse width are applied, action potentials are induced in muscles and nerves, resulting in muscle contraction phenomena, increasing the pain of patients in clinical treatment and easily causing electrode needle displacement, leading to inaccurate control of the ablation area. Most traditional electric pulse generators output bipolar symmetric electric pulses, and the pulse width and amplitude cannot be flexibly adjusted.

[0095] The pulse generation circuit, method, and device for outputting bipolar pulses provided by the present application aim to solve the above technical problems in the prior art.

[0096] The following uses specific embodiments to detail the technical solutions of the present application and how the technical solutions of the present application solve the above technical problems.

[0097] An embodiment of the present application provides a pulse generation circuit 100 for outputting bipolar pulses. Refer to Figure 1 As shown, the pulse generation circuit 100 for outputting bipolar pulses includes: a first charge and discharge unit 110 and a second charge and discharge unit 120.

[0098] The first charge and discharge unit 110 is used to be electrically connected to the first power supply unit 200 and the first end of the load 400, and the second charge and discharge unit 120 is used to be electrically connected to the second power supply unit 300 and the second end of the load 400.

[0099] The first charge and discharge unit 110 and the second charge and discharge unit 120 are used, in the charging mode, the first charge and discharge unit 110 is electrically connected to the first power supply unit 200, and the second charge and discharge unit 120 is electrically connected to the second power supply unit 300; in the pulse generation mode, the first charge and discharge unit 110 and the second charge and discharge unit 120 form a pulse generation loop with the load 400 to output a designed pulse signal to the load 400; the designed pulse signal is at least one of the following: a first polarity pulse signal, a second polarity pulse signal, a first polarity stepped amplitude pulse signal, and a second polarity stepped amplitude pulse signal.

[0100] Optionally, both the first power supply unit 200 and the second power supply unit 300 may include at least one charging power supply, and the charging voltages provided by each charging power supply may be different.

[0101] Optionally, the load 400 is the ablation area of the human body that needs treatment.

[0102] The first charge-discharge unit 110 and the second charge-discharge unit 120 of the embodiments of the present application are respectively used to be electrically connected to the first end and the second end of the load 400, so that two polarities of pulse signals, namely the first-polarity pulse signal and the second-polarity pulse signal, can be output to the load 400 in the pulse generation mode. At the same time, the first charge-discharge unit 110 of the embodiments of the present application is used to be electrically connected to the first power supply unit 200, and the second charge-discharge unit 120 is used to be electrically connected to the second power supply unit 300 to charge the first charge-discharge unit 110 and the second charge-discharge unit 120 respectively, so that in the pulse generation mode, a first-polarity stepped amplitude pulse signal and a second-polarity stepped amplitude pulse signal can be output to the load 400. Therefore, the pulse generation circuit 100 for outputting bipolar pulses of the embodiments of the present application can output designed pulse signals according to requirements, avoid or reduce muscle contraction, thereby avoiding the problem of electrode needle displacement, reducing the discomfort of the patient's body, and further accurately controlling the ablation area and improving the ablation effect.

[0103] Optionally, both the first-polarity pulse signal and the second-polarity pulse signal can be rectangular pulse signals. The first polarity and the second polarity can be positive polarity and negative polarity respectively.

[0104] Optionally, the first-polarity stepped amplitude pulse signal and the second-polarity stepped amplitude pulse signal represent pulse signals of the first polarity and the second polarity with a stepped voltage amplitude.

[0105] Optionally, controlling the number of energy storage devices in the first charge-discharge unit 110 and the second charge-discharge unit 120 can achieve a stepped output of the voltage amplitude.

[0106] In some embodiments, referring to Figure 2 as shown, the first charge-discharge unit 110 includes at least one first charge-discharge module 111 and at least one second charge-discharge module 112.

[0107] The first power supply unit 200 includes a first power supply 210 and a second power supply 220; the voltage of the first power supply 210 is less than the voltage of the second power supply 220;

[0108] Each first charge-discharge module 111 is electrically connected in sequence and is respectively used to be electrically connected to the first power supply 210;

[0109] Each second charge-discharge module 112 is electrically connected in sequence and is respectively used to be electrically connected to the second power supply 220;

[0110] The last first charge-discharge module 111 and the first second charge-discharge module 112 are electrically connected.

[0111] Optionally, both the first charge-discharge module 111 and the second charge-discharge module 112 may include at least one energy storage device. By controlling the number of energy storage devices in the pulse generation circuit of the first charge-discharge module 111 and the second charge-discharge module 112, pulse signals with different voltage amplitudes can be achieved.

[0112] Optionally, the first charge-discharge module 111 includes at least two charge-discharge modules 111, and the second charge-discharge module 112 includes at least two second charge-discharge modules 112.

[0113] In some embodiments, combining and Figure 2 and Figure 3 As shown, the first end 11 of the first first charge-discharge module and the second end 12 of the first first charge-discharge module are electrically connected to the positive electrode and the negative electrode of the first power supply 210, respectively.

[0114] Among any two adjacent first charge-discharge modules 111, the first end of the latter first charge-discharge module 111 is electrically connected to the first end of the former first charge-discharge module 111, and the second end of the latter first charge-discharge module 111 is electrically connected to the third end of the former first charge-discharge module 111.

[0115] The third end 33 of the last first charge-discharge module is electrically connected to the second end 42 of the first second charge-discharge module.

[0116] Optionally, as shown in Figure 2 and Figure 3 As shown, the first end 41 of the first second charge-discharge module and the second end 42 of the first second charge-discharge module are electrically connected to the positive electrode and the negative electrode of the second power supply 220, respectively.

[0117] Among any two adjacent second charge-discharge modules 112, the first end of the latter second charge-discharge module 112 is connected to the first end of the former second charge-discharge module 112, and the second end of the latter second charge-discharge module 112 is connected to the third end of the former second charge-discharge module 112; the third end 63 of the last second charge-discharge module is connected to the first end of the load 400.

[0118] Optionally, as an example, as shown in Figure 2 As shown, the first charge-discharge module 111 includes the first first charge-discharge module 111, at least one intermediate first charge-discharge module 111, and the last first charge-discharge module 111, and the second charge-discharge module 112 includes the first second charge-discharge module 112, at least one intermediate second charge-discharge module 112, and the last second charge-discharge module 112.

[0119] The third end 13 of the first first charge-discharge module is connected to the second end 22 of the intermediate first charge-discharge module (i.e., Figure 2The second terminal 22 of the first intermediate charge-discharge module is electrically connected to the second terminal 22 of the first intermediate charge-discharge module. The first terminal 21 of the intermediate first charge-discharge module is electrically connected to the first terminal 11 of the first first charge-discharge module, that is, electrically connected to the positive electrode of the first power supply 210, and is also electrically connected to the first terminals of all the first charge-discharge modules 111. The third terminal 23 of the intermediate first charge-discharge module is electrically connected to the second terminal of the next first charge-discharge module 111. The first terminal 31 of the last first charge-discharge module is electrically connected to the positive electrode of the first power supply 210, and the second terminal 32 of the last first charge-discharge module is electrically connected to the third terminal 23 of the previous intermediate first charge-discharge module.

[0120] The third terminal 43 of the first second charge-discharge module is electrically connected to the second terminal 52 of the intermediate second charge-discharge module (i.e., Figure 2 the second terminal 52 of the first intermediate second charge-discharge module in

[0121] Optionally, the second terminal 22 of the intermediate first charge-discharge module and the second terminal 32 of the last first charge-discharge module can be directly electrically connected to the negative electrode of the first power supply 210 or electrically connected to the negative electrode of the first power supply 210 through the previous first charge-discharge module 111 in front of them; the second terminal 42 of the first second charge-discharge module, the second terminal 52 of the intermediate second charge-discharge module, and the second terminal 62 of the last second charge-discharge module can be directly electrically connected to the second power supply 220, or electrically connected to the negative electrode of the second power supply 220 through the previous charge-discharge modules in front of them (including the previous first charge-discharge module 111 and the second charge-discharge module 112).

[0122] Optionally, the negative electrodes of the first power supply 210 and the second power supply 220 are both grounded.

[0123] In some embodiments, referring to Figure 3 as shown, the first charge-discharge module 111 includes a first energy storage device, a first switching device, and a second switching device.

[0124] The first terminal of the first energy storage device and the second terminal of the second switching device together serve as the first terminal of the first charge-discharge module 111.

[0125] The second terminal of the first energy storage device and the first terminal of the first switching device together serve as the second terminal of the first charge-discharge module 111.

[0126] The second terminal of the first switching device and the first terminal of the second switching device together serve as the third terminal of the first charge and discharge module 111.

[0127] Optionally, in combination with Figure 2 As shown, the electrical connection relationships of the first energy storage device, the first switching device, and the second switching device of each first charge and discharge module 111 are the internal electrical connection relationships of the module. The first terminal of the first charge and discharge module 111 includes the first terminal 11 of the first first charge and discharge module, the first terminal 21 of the intermediate first charge and discharge module, and the first terminal 31 of the last first charge and discharge module. The second terminal of the first charge and discharge module 111 includes the second terminal 12 of the first first charge and discharge module, the second terminal 22 of the intermediate first charge and discharge module, and the second terminal 32 of the last first charge and discharge module. The third terminal of the first charge and discharge module 111 includes the third terminal 13 of the first first charge and discharge module, the third terminal 23 of the intermediate first charge and discharge module, and the third terminal 33 of the last first charge and discharge module.

[0128] Optionally, in combination with Figure 3 As shown, the first charge and discharge module 111 includes two first charge and discharge modules 111, namely the first first charge and discharge module 111 and the last first charge and discharge module 111.

[0129] Optionally, in combination with Figure 4 As shown, the control terminals of the first switching device and the second switching device are both used to be electrically connected to the control unit 500.

[0130] Optionally, the first energy storage device serves as an energy storage device and can realize the functions of charging and discharging. The first energy storage device is selected as a capacitor.

[0131] Optionally, the first switching device and the second switching device can be MOS (metal oxide semiconductor) transistors. The control unit 500 can control the disconnection and conduction of the first switching device and the second switching device, and pulse signals with different widths can be output through the control time of the control unit 500.

[0132] Optionally, the first charge and discharge unit 110 further includes at least one first diode.

[0133] In the first first charge and discharge unit 110, the positive electrode and the negative electrode of the first diode are respectively electrically connected to the positive electrode of the first power supply 210 and the first terminal of the first charge and discharge unit 110.

[0134] In any two adjacent first charge and discharge units 110, the positive electrode and the negative electrode of the first diode are respectively electrically connected to the first terminal of the previous first charge and discharge unit 110 and the first terminal of the next first charge and discharge unit 110.

[0135] Optionally, referring to Figure 3 As shown, in the first first charge-discharge unit 110, the positive and negative electrodes of the first diode are electrically connected to the positive electrode of the first power supply 210, the first end of the first energy storage device, and the second end of the second switching device, respectively.

[0136] In any two adjacent first charge-discharge units 110, the positive and negative electrodes of the first diode are electrically connected to the first end of the previous first energy storage device and the second end of the second switching device, and the first end of the next first energy storage device and the second end of the second switching device, respectively.

[0137] In some embodiments, referring to Figure 3 As shown, the second charge-discharge module 112 includes a second energy storage device, a third switching device, and a fourth switching device.

[0138] The first end of the second energy storage device and the second end of the fourth switching device together serve as the first end of the second charge-discharge module 112.

[0139] The second end of the second energy storage device and the first end of the third switching device together serve as the second end of the second charge-discharge module 112.

[0140] The second end of the third switching device and the first end of the fourth switching device together serve as the third end of the second charge-discharge module 112.

[0141] Optionally, in combination with Figure 2 As shown, the electrical connection relationships of the second energy storage device, the third switching device, and the fourth switching device of each second charge-discharge module 112 are the internal electrical connection relationships of the module. The first end of the second charge-discharge module 112 includes the first end 41 of the first second charge-discharge module, the first end 51 of the intermediate second charge-discharge module, and the first end 61 of the last second charge-discharge module; the second end of the second charge-discharge module 112 includes the second end 42 of the first second charge-discharge module, the second end 52 of the intermediate second charge-discharge module, and the second end 62 of the last second charge-discharge module; the third end of the second charge-discharge module 112 includes the third end 43 of the first second charge-discharge module, the third end 53 of the intermediate second charge-discharge module, and the third end 63 of the last second charge-discharge module.

[0142] In combination with Figure 4 As shown, the control ends of the third switching device and the fourth switching device are both used to be electrically connected to the control unit 500.

[0143] Optionally, the second energy storage device, as an energy storage device, can realize the functions of charging and discharging, and the second energy storage device is selected as a capacitor.

[0144] Optionally, the third switching device and the fourth switching device may be MOS (metal oxide semiconductor) transistors. The control unit 500 can control the disconnection and conduction of the third switching device and the fourth switching device, and pulse signals with different widths can be output through the control time of the control unit 500.

[0145] Optionally, referring to Figure 3 as shown, the second charge-discharge module 112 further includes at least one second diode.

[0146] In the first second charge-discharge module 112, the positive and negative electrodes of the second diode are electrically connected to the positive electrode of the second power supply 220 and the first end of the second charge-discharge module 112, respectively.

[0147] In any two adjacent second charge-discharge modules 112, the positive and negative electrodes of the second diode are electrically connected to the first end of the previous second charge-discharge module 112 and the first end of the next second charge-discharge module 112, respectively.

[0148] Optionally, referring to Figure 3 as shown, in the first second charge-discharge module 112, the positive and negative electrodes of the second diode are electrically connected to the positive electrode of the second power supply 220, the first end of the second energy storage device, and the second end of the fourth switching device, respectively.

[0149] In any two adjacent second charge-discharge modules 112, the positive and negative electrodes of the second diode are electrically connected to the first end of the previous second energy storage device and the second end of the fourth switching device, and the first end of the next second energy storage device and the second end of the fourth switching device, respectively.

[0150] In some embodiments, referring to Figure 2 and Figure 3 as shown, the second charge-discharge unit 120 includes at least one third charge-discharge module 121 and at least one fourth charge-discharge module 122.

[0151] The second power supply unit 300 includes a third power supply 310 and a fourth power supply 320; the voltage of the third power supply 310 is less than the voltage of the fourth power supply 320;

[0152] Each third charge-discharge module 121 is electrically connected in sequence and is respectively used to be electrically connected to the third power supply 310;

[0153] Each fourth charge-discharge module 122 is electrically connected in sequence and is respectively used to be electrically connected to the fourth power supply 320;

[0154] The last third charge-discharge module 121 is electrically connected to the first fourth charge-discharge module 122.

[0155] Optionally, both the third charge-discharge module 121 and the fourth charge-discharge module 122 may include at least one energy storage device. By controlling the number of energy storage devices in the pulse generation circuit of the third charge-discharge module 121 and the fourth charge-discharge module 122, pulse signals with different voltage amplitudes can be achieved.

[0156] In some embodiments, referring to Figure 2 and Figure 3 as shown, the first end 71 and the second end 72 of the first third charge-discharge module are electrically connected to the positive electrode and the negative electrode of the third power supply 310, respectively.

[0157] Among any two adjacent third charge-discharge modules 121, the first end of the latter third charge-discharge module 121 is electrically connected to the first end of the former third charge-discharge module 121, the second end of the latter third charge-discharge module 121 is electrically connected to the third end of the former third charge-discharge module 121, and the third end 93 of the last third charge-discharge module is electrically connected to the second end 102 of the first fourth charge-discharge module.

[0158] The first end 101 and the second end 102 of the first fourth charge-discharge module are electrically connected to the positive electrode and the negative electrode of the fourth power supply 320, respectively.

[0159] Among any two adjacent fourth charge-discharge modules 122, the first end of the latter fourth charge-discharge module 122 is connected to the first end of the former fourth charge-discharge module 122, the second end of the latter fourth charge-discharge module 122 is electrically connected to the third end of the former fourth charge-discharge module 122, and the third end 1203 of the last fourth charge-discharge module is electrically connected to the second end of the load 400.

[0160] Optionally, as an example, referring to Figure 2 as shown, the third charge-discharge module 121 includes the first third charge-discharge module 121, at least one intermediate third charge-discharge module 121, and the last third charge-discharge module 121, and the fourth charge-discharge module 122 includes the first fourth charge-discharge module 122, at least one intermediate fourth charge-discharge module 122, and the last fourth charge-discharge module 122.

[0161] The third end 73 of the first third charge-discharge module is connected to the second end 82 of the intermediate third charge-discharge module (i.e., Figure 2The second terminal 82 of the first intermediate third charge-discharge module is electrically connected. The first terminal 81 of the intermediate third charge-discharge module is electrically connected to the first terminal 71 of the first third charge-discharge module, that is, electrically connected to the positive pole of the third power supply 310, and is also electrically connected to the first terminals of all the third charge-discharge modules 121. The third terminal 83 of the intermediate third charge-discharge module is electrically connected to the second terminal of the next third charge-discharge module 121. The first terminal 91 of the last third charge-discharge module is electrically connected to the positive pole of the third power supply 310, and the second terminal 92 of the last third charge-discharge module is electrically connected to the third terminal 83 of the previous intermediate third charge-discharge module.

[0162] The third terminal 103 of the first fourth charge-discharge module is electrically connected to the second terminal 1102 of the intermediate fourth charge-discharge module (i.e., Figure 2 the second terminal 1102 of the first intermediate fourth charge-discharge module in [the text]). The first terminal 1101 of the intermediate fourth charge-discharge module is electrically connected to the first terminal 101 of the first fourth charge-discharge module, that is, electrically connected to the positive pole of the fourth power supply 320, and is also electrically connected to the first terminals of all the fourth charge-discharge modules 122. The third terminal 1103 of the intermediate fourth charge-discharge module is electrically connected to the second terminal of the next fourth charge-discharge module. The first terminal 1201 of the last fourth charge-discharge module is electrically connected to the positive pole of the fourth power supply 320, and the second terminal 1202 of the last fourth charge-discharge module is electrically connected to the third terminal 1103 of the previous intermediate fourth charge-discharge module.

[0163] Optionally, the second terminal 82 of the intermediate third charge-discharge module and the second terminal 92 of the last third charge-discharge module can be directly electrically connected to the negative pole of the third power supply 310 or electrically connected to the negative pole of the third power supply 310 through the previous third charge-discharge module 121 in front of them respectively; the second terminal 102 of the first fourth charge-discharge module, the second terminal 1102 of the intermediate fourth charge-discharge module, and the second terminal 1202 of the last fourth charge-discharge module can be directly electrically connected to the negative pole of the fourth power supply 320, or electrically connected to the negative pole of the fourth power supply 320 through the previous charge-discharge modules (including the previous third charge-discharge module 121 and the fourth charge-discharge module 122) in front of them respectively.

[0164] Optionally, the negative poles of both the third power supply 310 and the fourth power supply 320 are grounded.

[0165] In some embodiments, the third charge-discharge module 121 includes a third energy storage device, a fifth switching device, and a sixth switching device;

[0166] The first terminal of the third energy storage device and the second terminal of the sixth switching device together serve as the first terminal of the third charge-discharge module 121;

[0167] The second terminal of the third energy storage device and the first terminal of the fifth switching device together serve as the second terminal of the third charge-discharge module 121;

[0168] The second end of the fifth switching device and the first end of the sixth switching device jointly serve as the third end of the third charge-discharge module 121.

[0169] Optionally, in combination with Figure 2 As shown, the electrical connection relationships of the third energy storage device, the fifth switching device, and the sixth switching device of each third charge-discharge module 121 are the internal electrical connection relationships of the module. The first end of the third charge-discharge module 121 includes the first end 71 of the first third charge-discharge module, the first end 81 of the intermediate third charge-discharge module, and the first end 91 of the last third charge-discharge module. The second end of the third charge-discharge module 121 includes the second end 72 of the first third charge-discharge module, the second end 82 of the intermediate third charge-discharge module, and the second end 92 of the last third charge-discharge module. The third end of the third charge-discharge module 121 includes the third end 73 of the first third charge-discharge module, the third end 83 of the intermediate third charge-discharge module, and the third end 93 of the last third charge-discharge module.

[0170] Optionally, in combination with Figure 3 As shown, the third charge-discharge module 121 includes two third charge-discharge modules 121, namely the first third charge-discharge module 121 and the last third charge-discharge module 121.

[0171] In combination with Figure 4 As shown, the control ends of the fifth switching device and the sixth switching device are both used to be electrically connected to the control unit 500.

[0172] Optionally, the third energy storage device, as an energy storage device, can realize the functions of charging and discharging, and the third energy storage device selects a capacitor.

[0173] Optionally, the fifth switching device and the sixth switching device can be MOS (metal oxide semiconductor) transistors, and the control unit 500 can control the disconnection and conduction of the fifth switching device and the sixth switching device, and pulse signals with different widths can be output through the control time of the control unit 500.

[0174] Optionally, referring to Figure 3 As shown, the third charge-discharge module 121 further includes at least one third diode.

[0175] In the first third charge-discharge module 121, the positive electrode and the negative electrode of the third diode are respectively electrically connected to the positive electrode of the third power supply 310 and the first end of the third charge-discharge module 121.

[0176] Among any two adjacent third charge-discharge modules 121, the positive and negative electrodes of the third diode are electrically connected to the first end of the previous third charge-discharge module 121 and the first end of the next third charge-discharge module 121, respectively.

[0177] Optionally, referring to Figure 3 As shown, in the first third charge-discharge module 121, the positive and negative electrodes of the third diode are electrically connected to the positive electrode of the third power supply 310, the first end of the third energy storage device, and the second end of the sixth switching device, respectively.

[0178] Among any two adjacent first charge-discharge units 110, the positive and negative electrodes of the first diode are electrically connected to the first end of the previous third energy storage device and the second end of the sixth switching device, and the first end of the next third energy storage device and the second end of the sixth switching device, respectively.

[0179] In some embodiments, referring to Figure 3 As shown, the fourth charge-discharge module 122 includes a fourth energy storage device, a seventh switching device, and an eighth switching device.

[0180] The first end of the fourth energy storage device and the second end of the eighth switching device together serve as the first end of the fourth charge-discharge module 122.

[0181] The second end of the fourth energy storage device and the first end of the seventh switching device together serve as the second end of the fourth charge-discharge module 122.

[0182] The second end of the seventh switching device and the first end of the eighth switching device together serve as the third end of the fourth charge-discharge module 122.

[0183] Optionally, in combination with Figure 2 As shown, the electrical connection relationships of the fourth energy storage device, the seventh switching device, and the eighth switching device of each fourth charge-discharge module 122 are the internal electrical connection relationships of the module. The first end of the fourth charge-discharge module 122 includes the first end 101 of the first fourth charge-discharge module, the first end 1101 of the intermediate fourth charge-discharge module, and the first end 1201 of the last fourth charge-discharge module; the second end of the fourth charge-discharge module 122 includes the second end 102 of the first fourth charge-discharge module, the second end 1102 of the intermediate fourth charge-discharge module, and the second end 1202 of the last fourth charge-discharge module; the third end of the fourth charge-discharge module 122 includes the third end 103 of the first fourth charge-discharge module, the third end 1103 of the intermediate fourth charge-discharge module, and the third end 1203 of the last fourth charge-discharge module.

[0184] In combination with Figure 4 As shown, the control ends of the seventh switching device and the eighth switching device are both used to be electrically connected to the control unit 500.

[0185] Optionally, as an energy storage device, the fourth energy storage device can implement the functions of charging and discharging, and the second energy storage device is a capacitor.

[0186] Optionally, the seventh switching device and the eighth switching device can be MOS (metal oxide semiconductor) transistors. The control unit 500 can control the disconnection and conduction of the third switching device and the fourth switching device, and pulse signals with different widths can be output through the control time of the control unit 500.

[0187] Optionally, as shown in Figure 3 the fourth charge and discharge module 122 further includes at least one fourth diode.

[0188] In the first fourth charge and discharge module 122, the positive and negative electrodes of the fourth diode are electrically connected to the positive electrode of the fourth power supply 320 and the first end of the fourth charge and discharge module 122, respectively.

[0189] In any two adjacent fourth charge and discharge modules 122, the positive and negative electrodes of the fourth diode are electrically connected to the first end of the previous fourth charge and discharge module 122 and the first end of the next fourth charge and discharge module 122, respectively.

[0190] Optionally, as shown in Figure 3 in the first fourth charge and discharge module 122, the positive and negative electrodes of the fourth diode are electrically connected to the positive electrode of the fourth power supply 320, the first end of the fourth energy storage device, and the second end of the eighth switching device, respectively.

[0191] In any two adjacent fourth charge and discharge modules 122, the positive and negative electrodes of the fourth diode are electrically connected to the first end of the previous fourth energy storage device and the second end of the eighth switching device, and the first end of the next fourth energy storage device and the second end of the eighth switching device, respectively.

[0192] The pulse generation circuit 100 for outputting bipolar pulses according to the embodiments of the present application can, according to the differences in pulse amplitudes and pulse widths tolerated by different patients, adjust appropriate amplitude and pulse width electric pulses for the patients, reduce muscle contraction and electrode needle displacement phenomena, and can achieve precise control of the ablation area under a larger and spherical ablation area, and can also reduce the pain of patients in clinical treatment. At the same time, the pulse generation circuit 100 for outputting bipolar pulses according to the embodiments of the present application can achieve significantly larger and more spherical ablation, reduce thermal damage to normal tissue cells, eliminate complications related to arcs between electrodes, and is sufficient to cause irreversible electroporation in the treatment area.

[0193] Optionally, as an example, as shown in Figure 3As shown, the first charge-discharge unit 110 includes two first charge-discharge modules 111 and four second charge-discharge modules 112. The second charge-discharge unit 120 includes two third charge-discharge modules 121 and four fourth charge-discharge modules 122. The first power supply unit 200 includes a first power supply 210 and a second power supply 220, and the second power supply unit 300 includes a third power supply 310 and a fourth power supply 320.

[0194] Optionally, both DL1-1 and DL1-2 are first diodes, both CL1-1 and CL1-2 are first energy storage devices, both SL1-3 and SL1-4 are first switching devices, and both SL1-1 and SL1-2 are second switching devices; DH1-1, DH1-2, DH1-3, DH1-4, and DH1-5 are all second diodes, CH1-1, CH1-2, CH1-3, and CH1-4 are all second energy storage devices, SH1-5, SH1-6, SH1-7, and SH1-8 are all third switching devices, and SH1-1, SH1-2, SH1-3, and SH1-4 are all fourth switching devices; DL2-1 and DL2-2 are both third diodes, CL2-1 and CL2-2 are both third energy storage devices, SL2-3 and SL2-4 are both fifth switching devices, and SL2-1 and SL2-2 are both sixth switching devices; DH2-1, DH2-2, DH2-3, DH2-4, and DH2-5 are all fourth diodes, CH2-1, CH2-2, CH2-3, and CH2-4 are all fourth energy storage devices, SH2-5, SH2-6, SH2-7, and SH2-8 are all seventh switching devices, and SH2-1, SH2-2, SH2-3, and SH2-4 are all eighth switching devices.

[0195] Optionally, the first first charge-discharge module 111 includes DL1-1, CL1-1, SL1-3, and SL1-1; the second first charge-discharge module 111 includes DL1-2, CL1-2, SL1-4, and SL1-2; the first second charge-discharge module 112 includes DH1-1, DH1-2, CH1-1, SH1-5, and SH1-1, the second second charge-discharge module 112 includes DH1-3, CH1-2, SH1-6, and SH1-2, the third second charge-discharge module 112 includes DH1-4, CH1-3, SH1-7, and SH1-3, and the fourth second charge-discharge module 112 includes DH1-5, CH1-4, SH1-8, and SH1-4; the first third charge-discharge module 121 includes DL2-1, CL2-1, SL2-3, and SL2-1, and the second third charge-discharge module 121 includes DL2-2, CL2-2, SL2-4, and SL2-2; the first fourth charge-discharge module 122 includes DH2-1, DH2-2, CH2-1, SH2-5, and SH2-1, the second fourth charge-discharge module 122 includes DH2-3, CH2-2, SH2-6, and SH2-2, the third fourth charge-discharge module 122 includes DH2-4, CH2-3, SH2-7, and SH2-3, and the fourth fourth charge-discharge module 122 includes DH2-5, CH2-4, SH2-8, and SH2-4.

[0196] Optionally, DH1-1 and DH1-2 are connected in series, and DH2-1 and DH2-2 are connected in series.

[0197] Optionally, RL is a load 400, LVDC1 and HVDC1 are a first power supply 210 and a second power supply 220 respectively, and LVDC2 and HVDC2 are a third power supply 310 and a fourth power supply 320 respectively. LVDC1 and HVDC1 are a low-voltage power supply and a high-voltage power supply respectively, and LVDC2 and HVDC2 are a low-voltage power supply and a high-voltage power supply respectively. The voltages of LVDC1, HVDC1, LVDC2, and HVDC2 may all be different. In the embodiments of the present application, the voltages of LVDC1 and LVDC2 are the same, and the voltages of HVDC1 and HVDC2 are the same.

[0198] Based on the same inventive concept, the embodiments of the present application provide a pulse generating device for outputting bipolar pulses. Refer to Figure 4 As shown, the pulse generating device for outputting bipolar pulses includes: a control unit 500 and a pulse generating circuit 100 for outputting bipolar pulses according to any embodiment of the present application.

[0199] A control unit 500, electrically connected to both the first charge and discharge unit 110 and the second charge and discharge unit 120, is configured to control, in the charging mode, the first charge and discharge unit 110 to be electrically connected to the first power supply unit 200 and the second charge and discharge unit 120 to be electrically connected to the second power supply unit 300; in the pulse generation mode, control the first charge and discharge unit 110 and the second charge and discharge unit 120 to form a pulse generation loop with the load 400 to output a designed pulse signal to the load 400; the designed pulse signal includes at least one of the following: a first-polarity pulse signal, a second-polarity pulse signal, a first-polarity stepped amplitude pulse signal, and a second-polarity stepped amplitude pulse signal.

[0200] Optionally, the control unit 500 is configured to control the conduction and cutoff of each switching device in the first charge and discharge unit 110 and the second charge and discharge unit 120, so as to form different pulse generation loops, and can output different designed pulse signals according to different requirements.

[0201] In some embodiments, referring to Figure 4 as shown, the pulse generation device for outputting bipolar pulses further includes: a first power supply unit 200 and a second power supply unit 300.

[0202] The first power supply unit 200 is electrically connected to the first charge and discharge unit 110.

[0203] The second power supply unit 300 is electrically connected to the second charge and discharge unit 120.

[0204] Optionally, in combination with Figure 3 and Figure 4 as shown, the control unit 500 is electrically connected to the control terminals of the first switching device, the second switching device, the third switching device, the fourth switching device, the fifth switching device, the sixth switching device, the seventh switching device, and the eighth switching device respectively, and is configured to control the conduction and cutoff of each switching device, that is, the control terminals of all MOS transistors shown in the figure are electrically connected to the control unit 500.

[0205] The pulse generation device for outputting bipolar pulses according to the embodiments of the present application is used for irreversible electroporation, can output bipolar stepped high-voltage and low-voltage pulse signals, and has a topological structure of a bipolar pulse generation loop capable of flexibly adjusting the pulse width. By releasing high-voltage pulse signals, multiple nano-scale irreversible pores are formed on the cell membrane surface, promoting apoptosis and the occurrence of the body's immune response, thereby achieving the effect of controlling tumors.

[0206] Based on the same inventive concept, the embodiments of the present application provide a pulse generation method, which is applied to the pulse generation circuit 100 for outputting bipolar pulses according to any embodiment of the present application. Referring to Figure 5 as shown, the pulse generation method includes: step S501 to step S502.

[0207] S501. In the charging mode, control the first charge-discharge unit 110 to be electrically connected to the first power supply unit 200, and the second charge-discharge unit 120 to be electrically connected to the second power supply unit 300.

[0208] Optionally, in the charging mode, the control unit 500 controls the first charge-discharge unit 110 to be electrically connected to the first power supply unit 200, and the second charge-discharge unit 120 to be electrically connected to the second power supply unit 300.

[0209] Optionally, each step of the pulse generation method according to the embodiment of the present application is executed by the control unit 500.

[0210] Optionally, both the first charge-discharge unit 110 and the second charge-discharge unit 120 include a plurality of energy storage devices. In the charging mode, the control unit 500 controls both ends of each energy storage device to be electrically connected to the corresponding power supply unit respectively to charge each energy storage device.

[0211] Optionally, Figure 6 shows Figure 3 a schematic structural diagram of the charging circuit in the charging mode of the shown circuit structure. Some switching devices are turned on and some are turned off. For the convenience of understanding the charging process, the turned-on switching devices are retained in the figure, and the turned-off switching devices are not shown in the figure.

[0212] Combined with Figure 3 、 Figure 6 and Figure 11 as shown, at the time of 0-T1, the control unit 500 controls the switching devices SL1-(3-4), SH1-(5-8), SL2-(3-4), and SH2-(5-8) to be in the on state, and the rest of the switching devices are in the off state. At this time, the low-voltage power supply LVDC1 and the high-voltage power supply HVDC1 charge CL(1-2)-(1-2) and CH(1-2)-(1-4) respectively. The voltages on the four capacitors of CL(1-2)-(1-2) are all V1, and the voltages on the eight capacitors of CH(1-2)-(1-4) are all V2.

[0213] S502. In the pulse generation mode, control the first charge-discharge unit 110 and the second charge-discharge unit 120 to form a pulse generation loop with the load 400 to output a designed pulse signal to the load 400; the designed pulse signal is at least one of the following: a first-polarity pulse signal, a second-polarity pulse signal, a first-polarity stepped amplitude pulse signal, and a second-polarity stepped amplitude pulse signal.

[0214] Optionally, in the pulse generation mode, the control unit 500 controls the first charge-discharge unit 110 and the second charge-discharge unit 120 to form a pulse generation loop with the load 400 to output a designed pulse signal to the load 400.

[0215] In some embodiments, controlling the first charge-discharge unit 110 and the second charge-discharge unit 120 to form a pulse generation circuit with the load 400 to output a designed pulse signal to the load 400 includes:

[0216] Controlling some devices in the first charge-discharge module 111 and the second charge-discharge module 112 of the first charge-discharge unit 110 to be connected in series, and some devices in the third charge-discharge module 121 and the fourth charge-discharge module 122 of the second charge-discharge unit 120 to be connected in series, to form a pulse generation circuit with the load 400. The pulse generation circuit includes at least one energy storage device in the first charge-discharge unit 110 and / or at least one energy storage device in the second charge-discharge unit 120.

[0217] Optionally, the control unit 500 controls some devices in the first charge-discharge module 111 and the second charge-discharge module 112 of the first charge-discharge unit 110 to be connected in series, and some devices in the third charge-discharge module 121 and the fourth charge-discharge module 122 of the second charge-discharge unit 120 to be connected in series, to form a pulse generation circuit with the load 400.

[0218] Optionally, the pulse generation circuits with different device combinations can adjust the amplitude of the output pulse signal according to the number of energy storage devices. When all the energy storage devices in the first charge-discharge unit 110 discharge in the pulse generation circuit, a first-polarity pulse signal with the maximum voltage amplitude is output to the load 400. When all the energy storage devices in the second charge-discharge unit 120 discharge in the pulse generation circuit, a second-polarity pulse signal with the maximum voltage amplitude is output to the load 400.

[0219] In some embodiments, controlling some devices in the first charge-discharge module 111 and the second charge-discharge module 112 of the first charge-discharge unit 110 to be connected in series, and some devices in the third charge-discharge module 121 and the fourth charge-discharge module 122 of the second charge-discharge unit 120 to be connected in series, to form a pulse generation circuit with the load 400 includes:

[0220] Controlling that in the first charge-discharge module 111, the second charge-discharge module 112, the third charge-discharge module 121, and the fourth charge-discharge module 122, one switching device is turned off and the other switching device is turned on, to form a pulse generation circuit with the load 400.

[0221] Optionally, the control unit 500 controls that in the first charge-discharge module 111, the second charge-discharge module 112, the third charge-discharge module 121, and the fourth charge-discharge module 122, one switching device is turned off and the other switching device is turned on, to form a pulse generation circuit with the load 400.

[0222] Optionally, in combination with Figure 3As shown, the control unit 500 controls the first charge and discharge module 111, the second charge and discharge module 112, the third charge and discharge module 121, and the fourth charge and discharge module 122, such that in each case, one switching device is turned off and the other switching device is turned on, forming a pulse generation circuit with the load 400, including:

[0223] Controlling the first switching device in the first charge and discharge module 111 to be turned off and the second switching device to be turned on, the third switching device in the second charge and discharge module 112 to be turned on and the fourth switching device to be turned off, the fifth switching device in the third charge and discharge module 121 to be turned on and the sixth switching device to be turned off, and the seventh switching device in the fourth charge and discharge module 122 to be turned on and the eighth switching device to be turned off; and / or,

[0224] Controlling the first switching device in the first charge and discharge module 111 to be turned on and the second switching device to be turned off, the third switching device in the second charge and discharge module 112 to be turned on and the fourth switching device to be turned off, the fifth switching device in the third charge and discharge module 121 to be turned off and the sixth switching device to be turned on, and the seventh switching device in the fourth charge and discharge module 122 to be turned on and the eighth switching device to be turned off; and / or,

[0225] Controlling the first switching device in the first charge and discharge module 111 to be turned on and the second switching device to be turned off, the third switching device in the second charge and discharge module 112 to be turned off and the fourth switching device to be turned on, the fifth switching device in the third charge and discharge module 121 to be turned on and the sixth switching device to be turned off, and the seventh switching device in the fourth charge and discharge module 122 to be turned on and the eighth switching device to be turned off; and / or,

[0226] Controlling the first switching device in the first charge and discharge module 111 to be turned on and the second switching device to be turned off, the third switching device in the second charge and discharge module 112 to be turned off and the fourth switching device to be turned on, the fifth switching device in the third charge and discharge module 121 to be turned on and the sixth switching device to be turned off, and the seventh switching device in the fourth charge and discharge module 122 to be turned on and the eighth switching device to be turned off.

[0227] In some embodiments, controlling the first charge and discharge module 111, the second charge and discharge module 112, the third charge and discharge module 121, and the fourth charge and discharge module 122, such that in each case, one switching device is turned off and the other switching device is turned on, forming a pulse generation circuit with the load 400, including:

[0228] Controlling the first charge and discharge module 111, the second charge and discharge module 112, the third charge and discharge module 121, and the fourth charge and discharge module 122, such that the energy storage devices of one charge and discharge module are all in the pulse generation circuit, and the energy storage devices of the remaining charge and discharge modules are not in the pulse generation circuit, so as to output a first-polarity pulse signal and / or a second-polarity pulse signal with at least one voltage amplitude to the load 400.

[0229] Optionally, the first polarity pulse signal is a positive polarity pulse signal, and the second polarity pulse signal is a negative polarity pulse signal. The voltages of LVDC1 and LVDC2 are low voltage V1, and the voltages of HVDC1 and HVDC2 are high voltage V2.

[0230] Optionally, Figures 7 to 10 respectively show Figure 3 structural schematic diagrams of pulse generation circuits that respectively output a positive polarity low voltage pulse signal, a negative polarity low voltage pulse signal, a positive polarity high voltage pulse signal, and a negative polarity high voltage pulse signal in the pulse generation mode for the circuit structures shown.

[0231] Optionally, referring to Figure 9 and Figure 11 as shown, at time T2 - T3, the control unit 500 controls the switching devices SL1-(3 - 4), SH1-(1 - 4), SL2-(3 - 4), SH2-(5 - 8) to be in the conducting state, and the remaining switching devices are in the off state. At this time, the pulse generation circuit applies a positive polarity high voltage pulse signal of 4 times V2 across the load RL.

[0232] Optionally, referring to Figure 10 and Figure 11 as shown, at time T4 - T5, the control unit 500 controls the switching devices SL1-(3 - 4), SH1-(5 - 8), SL2-(3 - 4), SH2-(1 - 4) to be in the conducting state, and the remaining switching devices are in the off state. At this time, the pulse generation circuit applies a negative polarity high voltage pulse signal of 4 times V2 across the load RL.

[0233] Optionally, referring to Figure 7 and Figure 11 as shown, at time T6 - T7, the control unit 500 controls the switching devices SL1-(1 - 2), SH1-(5 - 8), SL2-(3 - 4), SH2-(5 - 8) to be in the conducting state, and the remaining switching devices are in the off state. At this time, the pulse generation circuit applies a positive polarity low voltage pulse signal of 2 times V1 across the load RL.

[0234] Optionally, referring to Figure 8 and Figure 11 as shown, at time T8 - T9, the control unit 500 controls the switching devices SL1-(3 - 4), SH1-(5 - 8), SL2-(1 - 2), SH2-(5 - 8) to be in the conducting state, and the remaining switching devices are in the off state. At this time, the pulse generation circuit applies a negative polarity low voltage pulse signal of 2 times V1 across the load RL.

[0235] Optionally, referring to Figure 11As shown, the positive high-voltage pulse signal, negative high-voltage pulse, positive low-voltage pulse signal, and negative pulse signal in the illustration are all rectangular pulse signals. Any one of the positive high-voltage pulse signal, negative high-voltage pulse, positive low-voltage pulse signal, and negative pulse signal can be used as the design pulse signal, and a combination of at least two pulse signals can also be used as the design pulse signal, which is selected according to actual requirements.

[0236] The pulse generation method of the embodiments of the present application can achieve the output of pulse signals with high or low voltage amplitudes by controlling the conduction of different switching devices, and can flexibly adjust the pulse width of the pulse signal by controlling the conduction time of different switching devices.

[0237] In some embodiments, when controlling the first charge-discharge module 111, the second charge-discharge module 112, the third charge-discharge module 121, and the fourth charge-discharge module 122, one switching device is disconnected and the other switching device is conducted to form a pulse generation loop with the load 400, including:

[0238] When controlling the first charge-discharge module 111, the second charge-discharge module 112, the third charge-discharge module 121, and the fourth charge-discharge module 122, the number of energy storage devices of one charge-discharge module in the pulse generation loop increases or decreases sequentially according to a predetermined time, and the energy storage devices of the remaining charge-discharge modules are not in the pulse generation loop, so as to output a first-polarity stepped amplitude pulse signal and / or a second-polarity stepped amplitude pulse signal to the load 400.

[0239] Optionally, the control unit 500 controls the first charge-discharge module 111, the second charge-discharge module 112, the third charge-discharge module 121, and the fourth charge-discharge module 122, and the number of energy storage devices of one charge-discharge module in the pulse generation loop increases or decreases sequentially according to a predetermined time, and the energy storage devices of the remaining charge-discharge modules are not in the pulse generation loop, so as to output a first-polarity stepped amplitude pulse signal and / or a second-polarity stepped amplitude pulse signal to the load 400.

[0240] Optionally, the sequential increase is from 0 to the number of all energy storage devices in the charge-discharge module in sequence, and the sequential decrease is from the number of all energy storage devices in the charge-discharge module to 0 in sequence.

[0241] Optionally, refer to Figure 9 and Figure 12As shown, from time T1 to time T5, the control unit 500 controls the switching device SH1-1 to be in the conducting state, and the second charge-discharge module 112 to which the switching device SH1-1 belongs outputs one V2 during the period from T1 to T5. From time T2 to time T6, the control unit 500 controls the switching device SH1-2 to be in the conducting state, and the second charge-discharge module 112 to which the switching device SH1-2 belongs outputs one V2 during the period from T2 to T6. From time T3 to time T7, the control unit 500 controls the switching device SH1-3 to be in the conducting state, and the second charge-discharge module 112 to which the switching device SH1-3 belongs outputs one V2 during the period from T3 to T7. From time T4 to time T8, the control unit 500 controls the switching device SH1-4 to be in the conducting state, and the second charge-discharge module 112 to which the switching device SH1-4 belongs outputs one V2 during the period from T4 to T8. From time T1 to time T8, the control unit 500 controls the switching devices SL(1~2)-(3~4), SH2-(5~8) to be in the conducting state, and the rest of the switching devices are in the off state. At this time, a stepped positive-polarity high-voltage pulse waveform as shown in the appendix Figure 12 will be generated.

[0242] Optionally, as shown in Figure 10 and Figure 12 , from time T9 to time T13, the control unit 500 controls the switching device SH2-1 to be in the conducting state, and the fourth charge-discharge module 122 to which the switching device SH2-1 belongs outputs one -V2 during the period from T9 to T13. From time T10 to time T14, the control unit 500 controls the switching device SH2-2 to be in the conducting state, and the fourth charge-discharge module 122 to which the switching device SH2-2 belongs outputs one -V2 during the period from T10 to T14. From time T11 to time T15, the control unit 500 controls the switching device SH2-3 to be in the conducting state, and the fourth charge-discharge module 122 to which the switching device SH2-3 belongs outputs one -V2 during the period from T11 to T15. From time T12 to time T16, the control unit 500 controls the switching device SH2-4 to be in the conducting state, and the fourth charge-discharge module 122 to which the switching device SH2-4 belongs outputs one -V2 during the period from T12 to T16. From time T9 to time T16, the control unit 500 controls the switching devices SL(1~2)-(3~4), SH1-(5~8) to be in the conducting state. The rest of the switching devices are in the off state. At this time, a stepped negative-polarity high-voltage pulse waveform as shown in the appendix Figure 12 will be generated.

[0243] Optionally, as shown in Figure 7 and Figure 13As shown, from time T1 to time T3, the control unit 500 controls the switching device SL1-1 to be in the conducting state, and the first charge-discharge module 111 to which the switching device SL1-1 belongs outputs one V1 during the period from T1 to T3. From time T2 to time T4, the control unit 500 controls the switching device SL1-2 to be in the conducting state, and the first charge-discharge module 111 to which the switching device SL1-2 belongs outputs one V1 during the period from T2 to T4. From time T1 to time T4, the control unit 500 controls the switching devices SL2-(3-4), SH(1-2)-(5-8) to be in the conducting state. The rest of the switching devices are all in the off state. At this time, a stepped positive-polarity low-voltage pulse waveform as shown in the appendix Figure 13 will be generated.

[0244] Optionally, as shown in Figure 8 and Figure 13 , from time T5 to time T7, the control unit 500 controls the switching device SL2-1 to be in the conducting state, and the third charge-discharge module 121 to which the switching device SL2-1 belongs outputs one -V1 during the period from T5 to T7. From time T6 to time T8, the control unit 500 controls the switching device SL2-2 to be in the conducting state, and the third charge-discharge module 121 to which the switching device SL2-2 belongs outputs one -V1 during the period from T6 to T8. From time T5 to time T8, the control unit 500 controls the switching devices SL1-(3-4), SH(1-2)-(5-8) to be in the conducting state. The rest of the MOS transistors are all in the off state. At this time, a stepped negative-polarity low-voltage pulse waveform as shown in the appendix Figure 13 will be generated.

[0245] The pulse generation method of the embodiment of the present application can output positive and negative stepped high-voltage and low-voltage electrical pulse signals. By increasing and decreasing the field strength amplitude slowly in a stepped manner, the phenomena of muscle contraction and electrode needle displacement are weakened, the discomfort of the patient's body is reduced, and muscle contraction is further avoided or alleviated, thereby avoiding the problem of electrode needle displacement.

[0246] The pulse generation method of the embodiment of the present application can output bipolar stepped high-voltage and low-voltage pulse signals as well as bipolar high-voltage and low-voltage pulse signals with normal waveforms by controlling the conduction of different switching devices. By controlling the conduction time of different switching devices, flexible adjustment of the pulse width can be achieved.

[0247] Those skilled in the art can understand that the various operations, methods, steps, measures, and solutions in the processes discussed in this application can be alternated, changed, combined, or deleted. Further, other steps, measures, and solutions in the various operations, methods, and processes discussed in this application can also be alternated, changed, rearranged, decomposed, combined, or deleted. Further, those in the prior art that have steps, measures, and solutions in the various operations, methods, and processes disclosed in this application can also be alternated, changed, rearranged, decomposed, combined, or deleted.

[0248] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of this application, unless otherwise specified, the meaning of "a plurality" is two or more.

[0249] In the description of this specification, specific features, structures, materials, or characteristics may be combined in a suitable manner in any one or more embodiments or examples.

[0250] It should be understood that although the steps in the flowchart of the accompanying drawings are shown in sequence according to the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless there is a clear indication in this document, the execution of these steps has no strict order limit and can be executed in other orders. Moreover, at least a part of the steps in the flowchart of the accompanying drawings may include multiple sub-steps or multiple stages. These sub-steps or stages are not necessarily executed at the same time but can be executed at different times, and their execution order is not necessarily sequential but can be executed alternately or in turn with at least a part of other steps or sub-steps or stages of other steps.

[0251] The above are only some of the implementation manners of this application. It should be noted that for those of ordinary skill in the art, without departing from the principle of this application, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of this application.

Claims

1. A pulse generation circuit for outputting bipolar pulses, characterized in that, Comprising: A first charge and discharge unit and a second charge and discharge unit; The first charge and discharge unit is used for electrically connecting with a first power supply unit and a first end of a load, and the second charge and discharge unit is used for electrically connecting with a second power supply unit and a second end of the load; The first charge and discharge unit and the second charge and discharge unit are configured such that, in a charging mode, the first charge and discharge unit is electrically connected to the first power supply unit, and the second charge and discharge unit is electrically connected to the second power supply unit to charge energy storage devices in their respective charge and discharge line modules; in a pulse generation mode, the first charge and discharge unit and the second charge and discharge unit form a pulse generation circuit with the load to output a designed pulse signal to the load; the designed pulse signal is at least one of the following: a first polarity pulse signal, a second polarity pulse signal, a first polarity stepped amplitude pulse signal, and a second polarity stepped amplitude pulse signal; The first charge and discharge unit includes at least one first charge and discharge module and at least one second charge and discharge module; the first power supply unit includes a first power supply and a second power supply; the voltage of the first power supply is less than the voltage of the second power supply; each of the first charge and discharge modules is sequentially electrically connected and is respectively used for electrically connecting with the first power supply; each of the second charge and discharge modules is sequentially electrically connected and is respectively used for electrically connecting with the second power supply; the last first charge and discharge module and the first second charge and discharge module are electrically connected; The second charge and discharge unit includes at least one third charge and discharge module and at least one fourth charge and discharge module; the second power supply unit includes a third power supply and a fourth power supply; the voltage of the third power supply is less than the voltage of the fourth power supply; each of the third charge and discharge modules is sequentially electrically connected and is respectively used for electrically connecting with the third power supply to store electrical energy provided by the third power supply during charging; each of the fourth charge and discharge modules is sequentially electrically connected and is respectively used for electrically connecting with the fourth power supply to store electrical energy provided by the fourth power supply during charging; the last third charge and discharge module and the first fourth charge and discharge module are electrically connected; The first end and the second end of the first first charge and discharge module are respectively electrically connected to the positive electrode and the negative electrode of the first power supply; among any two adjacent first charge and discharge modules, the first end of the latter first charge and discharge module is electrically connected to the first end of the former first charge and discharge module, and the second end of the latter first charge and discharge module is electrically connected to the third end of the former first charge and discharge module; the third end of the last first charge and discharge module is electrically connected to the second end of the first second charge and discharge module; the first end of the first second charge and discharge module is electrically connected to the positive electrode of the second power supply; among any two adjacent second charge and discharge modules, the first end of the latter second charge and discharge module is electrically connected to the first end of the former second charge and discharge module, and the second end of the latter second charge and discharge module is electrically connected to the third end of the former second charge and discharge module; the third end of the last second charge and discharge module is electrically connected to the first end of the load; The first end and the second end of the first third charge and discharge module are electrically connected to the positive electrode and the negative electrode of the third power supply respectively; among any two adjacent third charge and discharge modules, the first end of the latter third charge and discharge module is electrically connected to the first end of the former third charge and discharge module, the second end of the latter third charge and discharge module is electrically connected to the third end of the former third charge and discharge module, and the third end of the last third charge and discharge module is electrically connected to the second end of the first fourth charge and discharge module; the first end of the first fourth charge and discharge module is electrically connected to the positive electrode of the fourth power supply; among any two adjacent fourth charge and discharge modules, the first end of the latter fourth charge and discharge module is electrically connected to the first end of the former fourth charge and discharge module, the second end of the latter fourth charge and discharge module is electrically connected to the third end of the former fourth charge and discharge module, and the third end of the last fourth charge and discharge module is electrically connected to the second end of the load; The first charge and discharge unit and the second charge and discharge unit are used to control that in the first charge and discharge module, the second charge and discharge module, the third charge and discharge module and the fourth charge and discharge module, one switching device is turned off and the other switching device is turned on, forming a pulse generating circuit with the load, and controlling that the number of energy storage devices of one charge and discharge module in the pulse generating circuit increases or decreases sequentially according to a predetermined time, and the energy storage devices of the remaining charge and discharge modules are not in the pulse generating circuit, so as to output a first-polarity stepped amplitude pulse signal or a second-polarity stepped amplitude pulse signal to the load; Specifically, when outputting the first-polarity stepped amplitude pulse signal, the first charge and discharge module and the second charge and discharge module in the first charge and discharge unit sequentially put into energy storage devices according to a predetermined order, so that the output pulse amplitude starts from the lower amplitude corresponding to the first power supply and gradually increases to the higher amplitude corresponding to the second power supply, and then the energy storage period devices are sequentially withdrawn in the reverse order, so that the amplitude gradually decreases; When outputting the second-polarity stepped amplitude pulse signal, the third charge and discharge module and the fourth charge and discharge module in the second charge and discharge unit sequentially put into energy storage devices according to a predetermined order, so that the output pulse amplitude starts from the lower amplitude corresponding to the third power supply and gradually increases to the higher amplitude corresponding to the fourth power supply, and then the energy storage devices are sequentially withdrawn in the reverse order, so that the amplitude gradually decreases; The first charge and discharge unit and the second charge and discharge unit are also used to realize the output of different polarity pulse signals by controlling the conduction and disconnection of the switching devices. When outputting the first-polarity pulse signal, the first charge and discharge unit outputs a positive voltage to the first end of the load, and the second charge and discharge unit is grounded; when outputting the second-polarity pulse signal, the second charge and discharge unit outputs a negative voltage to the second end of the load, and the first charge and discharge unit is grounded.

2. The pulse generating circuit for outputting bipolar pulses according to claim 1, wherein The first charge and discharge module includes a first energy storage device, a first switching device and a second switching device; The first end of the first energy storage device and the second end of the second switching device together serve as the first end of the first charge-discharge module; The second end of the first energy storage device and the first end of the first switching device together serve as the second end of the first charge-discharge module; The second end of the first switching device and the first end of the second switching device together serve as the third end of the first charge-discharge module; The control ends of the first switching device and the second switching device are both used to be electrically connected to the control unit.

3. The pulse generation circuit for outputting bipolar pulses according to claim 1, characterized in that, The second charge-discharge module includes a second energy storage device, a third switching device, and a fourth switching device; The first end of the second energy storage device and the second end of the fourth switching device together serve as the first end of the second charge-discharge module; The second end of the second energy storage device and the first end of the third switching device together serve as the second end of the second charge-discharge module; The second end of the third switching device and the first end of the fourth switching device together serve as the third end of the second charge-discharge module; The control ends of the third switching device and the fourth switching device are both used to be electrically connected to the control unit.

4. The pulse generating circuit for outputting bipolar pulses according to claim 1, wherein, The third charge-discharge module includes a third energy storage device, a fifth switching device, and a sixth switching device; The first end of the third energy storage device and the second end of the sixth switching device together serve as the first end of the third charge-discharge module; The second end of the third energy storage device and the first end of the fifth switching device together serve as the second end of the third charge-discharge module; The second end of the fifth switching device and the first end of the sixth switching device together serve as the third end of the third charge-discharge module; The control ends of the fifth switching device and the sixth switching device are both used to be electrically connected to the control unit.

5. The pulse generation circuit for outputting bipolar pulses according to claim 1, wherein The fourth charge-discharge module includes a fourth energy storage device, a seventh switching device, and an eighth switching device; The first end of the fourth energy storage device and the second end of the eighth switching device together serve as the first end of the fourth charge-discharge module; The second end of the fourth energy storage device and the first end of the seventh switching device together serve as the second end of the fourth charge-discharge module; The second end of the seventh switching device and the first end of the eighth switching device together serve as the third end of the fourth charge-discharge module; The control ends of the seventh switching device and the eighth switching device are both used to be electrically connected to the control unit.

6. A pulse generating device for outputting bipolar pulses, characterized in that, Comprising: A control unit and a pulse generating circuit for outputting bipolar pulses as described in any one of claims 1-5; The control unit, which is electrically connected to both the first charge-discharge unit and the second charge-discharge unit, is used to, in the charging mode, control the first charge-discharge unit to be electrically connected to the first power supply unit and the second charge-discharge unit to be electrically connected to the second power supply unit; in the pulse generating mode, control the first charge-discharge unit and the second charge-discharge unit to form a pulse generating loop with the load to output a designed pulse signal to the load; the designed pulse signal is at least one of the following: a first polarity pulse signal, a second polarity pulse signal, a first polarity stepped amplitude pulse signal, and a second polarity stepped amplitude pulse signal.

7. The pulse generating device for outputting bipolar pulses according to claim 6, characterized in that, Further comprising: The first power supply unit and the second power supply unit; The first power supply unit is electrically connected to the first charge and discharge unit; The second power supply unit is electrically connected to the second charge and discharge unit.

8. A pulse generation method, applied to the pulse generation circuit for outputting bipolar pulses as described in any one of claims 1-5, characterized in that, Comprising: In the charging mode, control the first charge and discharge unit to be electrically connected to the first power supply unit, and the second charge and discharge unit to be electrically connected to the second power supply unit; In the pulse generation mode, control the first charge and discharge unit and the second charge and discharge unit to form a pulse generation loop with the load to output a designed pulse signal to the load; the designed pulse signal is at least one of the following: a first-polarity pulse signal, a second-polarity pulse signal, a first-polarity stepped amplitude pulse signal, and a second-polarity stepped amplitude pulse signal.

9. The pulse generation method according to claim 8, characterized in that, The controlling the first charge and discharge unit and the second charge and discharge unit to form a pulse generation loop with the load to output a designed pulse signal to the load includes: Control some devices in the first charge and discharge module and the second charge and discharge module of the first charge and discharge unit to be connected in series, and some devices in the third charge and discharge module and the fourth charge and discharge module of the second charge and discharge unit to be connected in series to form a pulse generation loop with the load, and the pulse generation loop includes at least one energy storage device in the first charge and discharge unit and / or at least one energy storage device in the second charge and discharge unit.

10. The pulse generation method according to claim 9, characterized in that, The controlling some devices in the first charge and discharge module and the second charge and discharge module of the first charge and discharge unit to be connected in series, and some devices in the third charge and discharge module and the fourth charge and discharge module of the second charge and discharge unit to be connected in series to form a pulse generation loop with the load includes: Control that in the first charge and discharge module, the second charge and discharge module, the third charge and discharge module, and the fourth charge and discharge module, one switching device is turned off and the other switching device is turned on to form a pulse generation loop with the load.

11. The pulse generation method according to claim 10, wherein The controlling that in the first charge and discharge module, the second charge and discharge module, the third charge and discharge module, and the fourth charge and discharge module, one switching device is turned off and the other switching device is turned on to form a pulse generation loop with the load includes: Control that in the first charge and discharge module, the second charge and discharge module, the third charge and discharge module, and the fourth charge and discharge module, the energy storage devices of one charge and discharge module are all in the pulse generation loop, and the energy storage devices of the remaining charge and discharge modules are not in the pulse generation loop to output a first-polarity pulse signal and / or a second-polarity pulse signal with at least one voltage amplitude to the load.

12. The pulse generation method according to claim 10, characterized in that, The controlling that in the first charge and discharge module, the second charge and discharge module, the third charge and discharge module, and the fourth charge and discharge module, one switching device is turned off and the other switching device is turned on to form a pulse generation loop with the load includes: Control the number of energy storage devices of one charge-discharge module among the first charge-discharge module, the second charge-discharge module, the third charge-discharge module, and the fourth charge-discharge module to increase or decrease sequentially according to a predetermined time in the pulse generation circuit, and the energy storage devices of the remaining charge-discharge modules are not in the pulse generation circuit, so as to output a first-polarity stepped amplitude pulse signal and / or a second-polarity stepped amplitude pulse signal to the load.

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