Esophageal auxiliary drug delivery device, PH capsule and esophageal fixation method of drug container

Abstract

The present invention discloses an esophageal auxiliary drug dispensing device, a PH capsule and a drug container esophageal fixation method, wherein the esophageal auxiliary drug dispensing device comprises a drug slot, and a soluble sealing sheet is connected to the opening of the drug slot. The soluble sealing sheet refers to a sealing sheet that is partially or completely soluble in gastric acid. The present invention has a simple structure, is easy to manufacture, and has high safety. In combination with a corresponding drug container esophageal fixation method, the drug dispensing is more direct, convenient, and timely, which can reduce the pain of drug dispensing for patients and has a better drug dispensing effect.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to an esophageal auxiliary drug dispensing device, a PH capsule and an esophageal fixing method for a drug container. Background Art

[0002] Gastroesophageal reflux refers to clinical gastroesophageal reflux disease and esophageal mucosal damage caused by excessive contact (or exposure) of the gastroesophageal cavity with gastric juice. The occurrence of gastroesophageal reflux and its complications is multifactorial. These include defects in the anti-reflux mechanism of the esophagus itself, such as dysfunction of the lower esophageal sphincter and abnormal motility of the esophageal body; there are also functional disorders of many mechanical factors outside the esophagus. The clinical manifestations of gastroesophageal reflux are complex and lack specificity. It is difficult to distinguish between physiological gastroesophageal reflux and pathological gastroesophageal reflux based on clinical manifestations alone. At present, comprehensive diagnostic techniques must be used. Whenever clinically found unexplained repeated vomiting, dysphagia, recurrent chronic respiratory infections, refractory asthma, growth retardation, recurrent suffocation, apnea and other symptoms, the possibility of gastroesophageal reflux should be considered. Necessary auxiliary examinations must be selected for different situations to clarify the diagnosis.

[0003] In the prior art, the wireless PH capsule detection system is a better gastroesophageal reflux diagnostic device. Its main principle is to hang a capsule-shaped device at a designated position in the subject's esophagus, and collect the pH value of the esophagus within a specified time (generally 96 hours) to determine whether the subject has acid reflux and the severity of the reflux phenomenon, providing data support for the doctor's diagnosis. At present, the wireless PH capsule is delivered to the designated position of the subject's esophagus with a guide device, and with the assistance of a negative pressure device, a part of the esophageal mucosa is sucked into the capsule body, and then the doctor completes the operation of hanging the capsule on the esophageal wall. After the capsule completes its work, it will automatically fall off in a week and finally be discharged from the lower digestive tract.

[0004] However, the current PH capsule can only detect data after being anchored in the human digestive tract, and has no other functions. In the case of gastroesophageal reflux, it is necessary to deliver medicine separately, and the medicine cannot be administered in time.

[0005] Therefore, those skilled in the art are committed to developing an esophageal auxiliary medication device, a PH capsule and an esophageal fixing method for a drug container which has a simple structure and can administer medication in a timely manner. Summary of the invention

[0006] In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is to provide an esophageal auxiliary medication device, a PH capsule and an esophageal fixing method for a medicine container which have a simple structure and can timely administer medication.

[0007] To achieve the above-mentioned purpose, the present invention provides an esophageal auxiliary drug delivery device, comprising a drug slot, wherein a soluble sealing sheet is connected to the opening of the drug slot. The present invention has a simple structure, and the soluble sealing sheet refers to a sealing sheet that is partially or completely soluble in gastric acid. When encountering gastric acid, the soluble sealing sheet dissolves, thereby exposing the drug in the drug slot for drug delivery.

[0008] Preferably, the soluble sealing sheet includes an outer contour portion and an inner connecting portion connected to each other.

[0009] Preferably, part or all of the outer contour portion is made of a low pH material soluble in acid, and part or all of the inner connecting portion is made of a material soluble in digestive juice.

[0010] Preferably, the outer contour is hollow, and the inner connecting portion is connected to the hollow portion of the outer contour.

[0011] Preferably, the inner connecting part is made of glutinous rice paper, which will dissolve when it comes into contact with water. The use of glutinous rice paper for the inner connecting part can well control the time of applying the pesticide.

[0012] The present invention also provides a PH capsule, comprising the esophagus auxiliary drug delivery device as described above.

[0013] Preferably, the medicine groove is connected to the sensor or the clamping seat of the pH capsule.

[0014] Preferably, the bottom of the medicine slot is connected to the sensor of the PH capsule, and the side of the soluble sealing sheet away from the medicine slot is connected to the clamping seat of the PH capsule.

[0015] The present invention also provides a method for fixing a medicine container in the esophagus, wherein the medicine container is anchored in the esophagus by negative pressure suction, wherein the medicine container is at least partially soluble in gastric acid.

[0016] Preferably, the medicine container is connected to a PH capsule, and the PH capsule is sucked onto the esophagus by negative pressure.

[0017] The beneficial effects of the present invention are as follows: the present invention has a simple structure, is easy to manufacture, and has high safety. When combined with a corresponding drug container esophagus fixing method, the drug administration is made more direct, convenient, and timely, which can reduce the pain of drug administration for patients and has a better drug administration effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic structural diagram of an esophageal auxiliary drug delivery device according to a specific embodiment of the present invention.

[0019] Figure 2 It is a schematic diagram of the explosion structure of a PH capsule according to a specific embodiment of the present invention.

[0020] Figure 3It is a schematic structural diagram of a PH capsule according to a specific embodiment of the present invention. DETAILED DESCRIPTION

[0021] The present invention is further described below in conjunction with the accompanying drawings and embodiments. It should be noted that in the description of the present invention, the directions or positional relationships indicated by the terms "upper", "lower", "left", "right", "inside", "outside", etc. are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific manner, and therefore cannot be understood as a limitation on the present invention.

[0022] like Figure 1 As shown, an esophageal auxiliary drug delivery device includes a drug slot 1, and a soluble sealing sheet 2 is connected to the opening of the drug slot 1. In this embodiment, the drug slot 1 is a plastic shell, made of a biocompatible material such as polycarbonate material or acrylic material, and has high stability and is insoluble in water, digestive juice, etc. Its function is to carry the drug.

[0023] The soluble sealing sheet 2 includes an outer contour portion 21 and an inner connecting portion 22 connected to each other, which together form a sealing surface at the opening of the medicine slot, and can seal the medicine in the medicine slot.

[0024] The outer part 21 is partially or entirely made of a low pH material that is soluble in acid. In this embodiment, the outer part 21 is hollow and frame-shaped, and the internal connection part 22 is connected to the hollow part of the outer part 21. The outer part 21 is entirely made of a low pH material that is soluble in acid. The low pH material that is soluble in acid is a material that meets biocompatibility. It will slowly melt under the action of solutions such as gastric acid. The melting time of the material can be adjusted according to the use requirements. The proportion of the components is generally ≧96 hours.

[0025] The inner connecting portion 22 is partially or entirely made of a material that dissolves in digestive juice. In this embodiment, the inner connecting portion 22 is entirely made of sticky rice paper. When the outer contour portion 21 made of a material that dissolves in a low pH value dissolves, the sticky rice paper can dissolve quickly after contacting the digestive juice.

[0026] The present invention also provides a PH capsule, comprising the above esophageal auxiliary drug delivery device. Specifically, the medicine slot 1 is connected to the sensor 3 or the clamping seat 4 of the PH capsule. In this embodiment, the bottom of the medicine slot 1 is connected to the sensor 3 of the PH capsule, and the soluble sealing sheet 2 is connected to the clamping seat 4 of the PH capsule away from the medicine slot 1. In this embodiment, the connection between the medicine slot 1 and the soluble sealing sheet 2 and the PH capsule is achieved by gluing.

[0027] The present invention also provides a method for fixing a medicine container in the esophagus, which can use the above-mentioned esophageal auxiliary drug delivery device to anchor the medicine container in the esophagus by negative pressure suction, wherein the medicine container is at least partially soluble in gastric acid. In this embodiment, the medicine container is connected to a PH capsule, and the PH capsule is negatively attracted to the esophagus.

[0028] When the esophageal auxiliary drug delivery device and the PH capsule of the present invention are used, the conveyor delivers the PH capsule with the esophageal auxiliary drug delivery device to the target position of the human esophagus, and uses negative pressure suction to anchor the PH capsule at the target position of the esophagus. The negative pressure suction method used by the PH capsule here is the same as that of the prior art and will not be repeated.

[0029] When reflux occurs, gastric acid reaches the position of the PH capsule, and the sensor will detect the PH value signal at this time, which is the basic detection function of the PH capsule. At the same time, gastric acid will contact with materials soluble in low PH values, and the material will begin to slowly dissolve under the action of gastric acid. When the material is completely dissolved, the rice paper will contact the digestive juice and begin to dissolve. When the two materials are dissolved, the PH capsule will disintegrate, and the clamping seat 4 may continue to remain on the esophagus for several hours to several days (depending on the person), and the sensor 3 and the medicine groove 1 and the medicine inside thereof will enter the stomach along the esophagus. The medicine will be released at this time, and the medicine can be administered in time, avoiding the pain caused by administering the medicine alone, and the administration method is more direct, with better administration effect.

[0030] If there is no gastroesophageal reflux, the pH capsule and the esophageal auxiliary drug delivery device can maintain integrity in the esophagus, and enter the stomach together after the clamping seat 4 is separated from the esophagus. Since the dissolution time of the low pH material is set to more than 96 hours, and the elimination time of the human body is generally 10-24 hours, the integrity of the capsule can still be guaranteed even if it comes into contact with gastric juice, so as to avoid the phenomenon of drug delivery without reflux.

[0031] The preferred specific embodiments of the present invention are described in detail above. It should be understood that a person skilled in the art can make many modifications and changes based on the concept of the present invention without creative work. Therefore, any technical solution that can be obtained by a person skilled in the art through logical analysis, reasoning or limited experiments based on the concept of the present invention on the basis of the prior art should be within the scope of protection determined by the claims.

Claims

1. An esophageal auxiliary drug delivery device, characterized in that: It comprises a medicine slot (1), wherein a soluble sealing sheet (2) is connected to the opening of the medicine slot (1); The soluble sealing sheet (2) is connected to the clamping seat (4) of the PH capsule at a side away from the medicine groove (1); The soluble sealing sheet (2) comprises an outer contour portion (21) and an inner portion (22) connected to each other, wherein the outer contour portion (21) is partially or entirely made of a low pH material soluble in acid; The outer contour part (21) is hollow, and the inner connecting part (22) is connected to the hollow part of the outer contour part (21); When esophageal reflux occurs, the outer contour portion (21) dissolves first, and then the inner connecting portion (22) begins to dissolve, and the medicine is administered after the inner connecting portion (22) dissolves; when there is no reflux, the medicine groove (1), the soluble sealing sheet (2) and the clamping seat (4) remain intact in the esophagus to avoid administration of medicine.

2. The esophageal auxiliary drug delivery device according to claim 1, characterized in that: The inner connecting portion (22) is partially or entirely made of a material that is soluble in digestive fluid.

3. The esophageal auxiliary drug delivery device according to claim 1, characterized in that: The internal connection part (22) is made of glutinous rice paper.

4. A PH capsule, characterized in that: It comprises the esophagus auxiliary drug administration device as described in any one of claims 1 to 3.

5. The PH capsule according to claim 4, characterized in that: The medicine groove (1) is connected to a sensor (3) or a clamping seat (4) of a PH capsule.

6. The PH capsule according to claim 4, characterized in that: The bottom of the medicine slot (1) is connected to a sensor (3) of a PH capsule, and the side of the soluble sealing sheet (2) away from the medicine slot (1) is connected to a clamping seat (4) of the PH capsule.

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