Compositions containing water-dispersible sunscreens and uses thereof

Abstract

The present invention provides a sunscreen composition comprising a water-dispersible sunscreen agent Tinosorb S lite Aqua, wherein the composition is in the form of an emulsified system or an oil gel. The present invention also relates to the use of the sunscreen composition in sunscreen products, wherein the sunscreen products are selected from the following forms: sunscreen cream for adults, sunscreen lotion for adults, sunscreen spray for adults, sunscreen lotion for infants and young children, and sunscreen spray for infants and young children.

Description

Technical Field

[0001] The invention relates to the field of cosmetics, and in particular to a sunscreen composition comprising a water-dispersible sunscreen agent Tinosorb S lite Aqua and application thereof. Background Art

[0002] Sunscreen products can provide a UV protection barrier for skin health. Ultraviolet radiation has many harmful effects on human health. These hazards include short-term hazards and long-term effects. Short-term hazards are mainly manifested as sunburn, suntan, and sunburn; long-term effects are often cumulative, manifested as skin erythema, photoaging, photodermatosis, and even skin cancer.

[0003] Ultraviolet rays are divided into three types according to their wavelengths: UVA, UVB, and UVC. UVC is blocked by the atmosphere and can hardly reach the earth's surface. However, UVA and UVB can partially penetrate the atmosphere and reach the earth's surface, and they can cause direct damage to the skin. With the intensification of environmental pollution, the earth's ozone layer has been damaged, so more and more ultraviolet rays are reaching the earth's surface. Therefore, it is essential to do a good job of sun protection in daily life.

[0004] In order to reduce the damage of ultraviolet radiation to the skin, people should try to avoid exposure to sunlight, especially during the period of time when the sun is strongest at noon. You can also protect yourself by wearing protective clothing. At the same time, you should use sunscreen cosmetics for protection before sun exposure. The use of sunscreen cosmetics is currently the most commonly used ultraviolet protection measure. It can prevent sunlight-induced erythema and sunburn, and prevent or reduce DNA damage. Regular use of sunscreen cosmetics can also inhibit precancerous skin damage and significantly reduce the occurrence of solar tumors.

[0005] Sunscreen is the core of sunscreen products and has a decisive influence on the performance of sunscreen products.

[0006] People are concerned about the safety of sunscreens, first of all, they are worried that the ingredients in sunscreens will cause some irritation to the skin. Indeed, most sunscreens will cause some irritation to the skin.

[0007] In addition, some people are concerned that some organic sunscreens may be absorbed through the skin or have potential interference with the endocrine system, but there is not enough clinical data to confirm these safety concerns. Since the use of sunscreens in the 1970s, there have been no reports of organic sunscreens causing systemic adverse reactions in humans. As for the effects of sunscreens on the endocrine system, the research results are all from in vitro and animal experiments and cannot be directly extended to humans.

[0008] Therefore, the proportion of sunscreen added should be minimized while ensuring its efficacy. At the same time, the components in the formula should be strictly screened to ensure the safety of the overall formula.

[0009] At the same time, the skin feel of sunscreen products is a very important consideration. The necessity of using sunscreen has been recognized by most consumers, and the sales of sunscreen products have been increasing year by year. However, complaints about the skin feel of sunscreen have never stopped. Many consumers complain that sunscreen is shiny, sticky, thick, etc., and it is uncomfortable to use; some people also complain about the trouble, and they have to use makeup remover to wash it off after use, otherwise it will not be washed clean. Therefore, the frequency of use of sunscreen products is far less than that of other skin care products (such as creams and lotions). Therefore, the user experience and feeling of sunscreen products is also one of the important indicators of the product.

[0010] The skin feel problem of sunscreen products is mainly because chemical sunscreens are mostly oils or lipophilic compounds. For liquid oil-based sunscreens, they can be directly added and emulsified during formulation; but for solid sunscreens, other liquid oils need to be used as solvents to dissolve them before adding them to the formula. This type of solid sunscreen has better stability and better safety, but at the same time their solubility in oils is also very low. For example, bis-ethylhexyloxyphenol methoxyphenyl triazine is a sunscreen that has good stability, high safety, and can protect against UVB and UVA at the same time, but its solubility in oils is very low. This means that when using it, a large amount of polar oil needs to be added to dissolve it first. The result is that the skin feel of the formula is greasy and not refreshing. The sunscreen product used in this application is a water dispersion made of bis-ethylhexyloxyphenol methoxyphenyl triazine through dispersion and emulsification technology. It can be directly added to the formula to solve the problem of greasy skin feel.

[0011] CN102655850A invented a novel polyglycerol-based UV filter that can improve the solubility of solid sunscreens. Its solubility in bis-ethylhexyloxyphenol methoxyphenyl triazine only increased from 13% to 18%, and it still required more than 5 times the amount of heavy oil as a solvent, which had limited improvement on the skin feel of the formula.

[0012] CN111050742 prepares a polymer dispersion with an average particle size of less than 1000 nm and applies it to an oil-in-water system. However, the system contains alcohol and is prone to cause irritation.

[0013] CN113576935A uses silica-encapsulated bis-ethylhexyloxyphenol methoxyphenyl triazine to improve safety. The water-dispersible bis-ethylhexyloxyphenol methoxyphenyl triazine described in the patent can not only improve safety, but also provide water resistance and play a sunscreen synergistic role.

[0014] However, the present invention innovatively applies Tinosorb S lite Aqua, a new type of water-dispersible sunscreen, to different types of sunscreen products. For example, Tinosorb S lite Aqua can be applied to water-in-oil emulsion systems to achieve ideal skin feel. Alternatively, Tinosorb S lite Aqua can even be applied to pure oil formulations, which adjusts the skin feel of pure oil system formulations and increases sunscreen efficacy. Summary of the invention

[0015] In one aspect, the present invention provides a sunscreen composition comprising a water-dispersible sunscreen, wherein the composition is in the form of an emulsion system or an oil gel. In a preferred embodiment, the water-dispersible sunscreen is Tinosorb S lite Aqua.

[0016] In a preferred embodiment, the sunscreen composition of the present invention is an emulsified system comprising:

[0017] 2-12 wt. % Tinosorb S Lite Aqua;

[0018] 0.1-10 wt % of an emulsifier;

[0019] 0.2-5% by weight of a thickener;

[0020] 5-20% by weight of fat; and

[0021] water.

[0022] In a preferred embodiment, the emulsifier in the emulsified sunscreen composition is selected from: steareth-21, C14-22 alcohol / C12-20 alkyl glucoside or a combination thereof. In a preferred embodiment, the content of steareth-21 is no more than 4% by weight based on the total weight of the sunscreen composition. In a preferred embodiment, the thickener in the emulsified sunscreen composition is an acrylate / vinyl isodecanoate crosspolymer. In a preferred embodiment, the oil in the emulsified sunscreen composition is selected from: dicaprylyl carbonate, dibutyl adipate, isononyl isononanoate or a combination thereof.

[0023] In a preferred embodiment, the sunscreen composition is in the form of an oil gel comprising:

[0024] 2-12 wt. % Tinosorb S Lite Aqua;

[0025] 0.2-5 wt% thickener; and

[0026] grease.

[0027] In a preferred embodiment, the thickener in the oil gel form sunscreen composition is silica dimethyl silylate. In a preferred embodiment, the oil in the oil gel form sunscreen composition is selected from: dicaprylyl carbonate, polydimethylsiloxane or a combination thereof.

[0028] On the other hand, the present invention also provides the use of the sunscreen composition in sunscreen products, wherein the sunscreen products are selected from the following forms: sunscreen cream for adults, sunscreen lotion for adults, sunscreen spray for adults, sunscreen lotion for infants and young children, and sunscreen spray for infants and young children. DETAILED DESCRIPTION

[0029] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as commonly understood by those of ordinary skill in the art to which the invention belongs. Although any methods and materials similar or equivalent to those described herein can be used to implement or test the present invention, preferred methods and materials are described herein. For purposes of the present invention, the following terms are defined below.

[0030] As used herein, the term "about" refers to an amount, level, value, dimension, size, or amount that differs by up to 30%, 20%, or 10% compared to the amount, level, value, dimension, size, or amount of a reference product. Percentages used herein, unless otherwise indicated, are by weight.

[0031] Throughout the specification and claims, unless otherwise required, the following words "comprise" and variations "comprising" and "including" will be understood to imply the inclusion of a stated integer or step, or a group of integers or steps, but not the exclusion of any other integer or step, or other group of integers or steps.

[0032] According to the present invention, the term "cosmetics" refers to chemical industrial products or fine chemical products that are spread on any part of the human body surface, such as skin, hair, nails, lips and teeth, etc., by smearing, spraying or other similar methods, in order to achieve the purpose of cleaning, maintenance, beautification, modification and change of appearance, or correction of human body odor and maintenance of good condition.

[0033] As used herein, "sunscreen composition" refers to a formulation (e.g., a lotion, spray, gel, or other topical product) that absorbs and / or reflects some of the sun's ultraviolet (UV) radiation and thereby helps prevent the negative effects of sun exposure (e.g., sunburn, premature aging, etc.).

[0034] The present invention selects Tinosorb S lite Aqua, a new type of water-dispersible sunscreen, as the research object, applies it to different dispersion systems, and studies the stability of the system (including stability at room temperature, 4°C, -15°C, 40°C and 48°C) and the sunscreen effect.

[0035] The present invention unexpectedly found that the aqueous dispersion of Tinosorb S lite Aqua prepared by dispersion emulsification technology not only has good stability, but also has high sunscreen efficiency. In addition, Tinosorb S lite Aqua can also be applied to pure oil formulations, and can also achieve ideal stability (including stability at room temperature, 4°C, -15°C, 40°C and 48°C). Therefore, the system using Tinosorb S lite Aqua as a sunscreen has good stability and high sunscreen efficiency, which can alleviate the common greasy skin feeling problem of sunscreen products.

[0036] Emulsifier

[0037] In some preferred embodiments of the present invention, the emulsifier used in the sunscreen composition is selected from: Steareth-21 (for example, trade name Eumulgin S 21, provided by BASF); C14-22 alcohol / C12-20 alkyl glucoside (for example, trade name Montanov L, provided by SEPPIC); or a combination thereof.

[0038] In some embodiments, the sunscreen composition may include about 0.1-10 weight % emulsifier based on the total weight of the composition. In some embodiments, the composition may include about 0.5-8 weight % emulsifier based on the total weight of the composition. In some embodiments, the composition may include about 0.5-5 weight % emulsifier based on the total weight of the composition. In some embodiments, the composition may include about 2-5 weight % emulsifier based on the total weight of the composition.

[0039] In some embodiments, the sunscreen composition may include a combination of steareth-21 and C14-22 alcohol / C12-20 alkyl glucoside as an emulsifier. In a specific embodiment, the sunscreen composition includes about 4-5% by weight of the emulsifier based on the total weight of the composition. The composition may include about 4.5% by weight of the emulsifier based on the total weight of the composition.

[0040] Thickener

[0041] In some preferred embodiments of the present invention, the thickener used in the sunscreen composition is selected from: acrylic acid (esters) / vinyl isodecanoate crosspolymer (trade name Stabylen-30, provided by 3V SIGMA); dimethyl silylate silica (trade name HDK H20, provided by WACKER); or a combination thereof.

[0042] In some embodiments, the sunscreen composition may include about 0.2-5 wt % of a thickener based on the total weight of the composition. The composition may include about 0.2-1 wt % of a thickener based on the total weight of the composition.

[0043] grease

[0044] In some preferred embodiments of the present invention, the sunscreen composition contains oil, and the oil is selected from: dicaprylyl carbonate (trade name Cetiol CC, provided by BASF); dibutyl adipate (trade name Cetiol B, provided by BASF); isononyl isononanoate (trade name LANOL99, provided by SEPPIC); polydimethylsiloxane (trade name Belsil DM 1 PLUS, provided by Wacker) or a combination thereof.

[0045] In some embodiments, the sunscreen composition may include about 5-20 wt % of the oil based on the total weight of the composition. The composition may include about 5-15 wt % of the oil based on the total weight of the composition.

[0046] In other embodiments, the sunscreen composition may include at least about 70% by weight of oil based on the total weight of the composition. The composition may include at least about 80% by weight of oil based on the total weight of the composition. The composition may include at least about 95% by weight of oil based on the total weight of the composition.

[0047] Sunscreen

[0048] In some embodiments, the sunscreen composition comprises a water-dispersible sunscreen. For example, the sunscreen composition comprises phenylbenzimidazole sulfonic acid (trade name Neo Hydro, provided by Symrise AG); bis-ethylhexyloxyphenol methoxyphenyl triazine, acrylates / C12-22 alkyl methacrylate copolymer, arginine, coco-glucoside, disodium lauryl sulfosuccinate, water (trade name Tinosorb S Lite Aqua, provided by BASF); or combinations thereof.

[0049] In some embodiments, the sunscreen composition may include about 2-12 weight % of a water-dispersible sunscreen based on the total weight of the composition. The composition may include about 2-10 weight % of a water-dispersible sunscreen based on the total weight of the composition. In a preferred embodiment, the sunscreen composition includes about 8 weight % of a water-dispersible sunscreen based on the total weight of the composition.

[0050] In some specific embodiments, the sunscreen composition of the present invention comprises about 2-12% by weight of Tinosorb SLite Aqua. The composition may comprise about 2-10% by weight of Tinosorb S Lite Aqua based on the total weight of the composition. In a preferred embodiment, the sunscreen composition comprises about 8% by weight of Tinosorb S Lite Aqua based on the total weight of the composition.

[0051] In some embodiments, the sunscreen composition comprises an oil-soluble sunscreen. For example, the sunscreen composition comprises ethylhexyl triazone (e.g., trade name Uvinul T 150, provided by BASF); methylene bis-benzotriazole tetramethylbutylphenol (trade name Tinosorb M, provided by BASF); ethylhexyl methoxycinnamate; ethylhexyl salicylate; or a combination thereof.

[0052] In some embodiments, the sunscreen composition may include about 2-20 weight % of an oil-soluble sunscreen based on the total weight of the composition. The composition may include about 2-15 weight % of an oil-soluble sunscreen based on the total weight of the composition. In a preferred embodiment, the sunscreen composition includes about 10-15 weight % of an oil-soluble sunscreen based on the total weight of the composition.

[0053] In some embodiments, the sunscreen composition of the present invention comprises a combination of a water-dispersible sunscreen and an oil-soluble sunscreen. In some embodiments, the sunscreen composition may comprise about 2-30% by weight of one or more sunscreens based on the total weight of the composition. The composition may comprise about 2-25% by weight of one or more sunscreens based on the total weight of the composition.

[0054] In some embodiments, the sunscreen compositions of the present invention comprise a combination of bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, Tinosorb M, and Tinosorb S Lite Aqua.

[0055] Topical compositions

[0056] In some embodiments, the pH value of the sunscreen composition of the present invention is 6 to 8. In a preferred embodiment, the pH value of the sunscreen composition of the present invention is 6.5 to 7.5.

[0057] In some embodiments, the sunscreen composition of the present invention may be a water-dispersible sunscreen composition comprising a water-dispersible sunscreen agent Tinosorb Slite Aqua, wherein the composition comprises: an emulsifier; a thickener; oil; and water. The composition may be prepared using a dispersion emulsification technique.

[0058] In some embodiments, the sunscreen composition of the present invention may be an oil gel type sunscreen composition comprising a water-dispersible sunscreen agent Tinosorb Slite Aqua. The composition may comprise dicaprylyl carbonate and polydimethylsiloxane as oils and fats. The composition may comprise silica dimethyl silylate as a thickener.

[0059] The compositions can be prepared using mixing and blending methods well known in the sunscreen and cosmetic arts.

[0060] The composition may be combined with a "cosmetically acceptable topical carrier," ie, a topical carrier capable of containing the other ingredients dispersed or dissolved therein and possessing acceptable properties rendering it safe for topical use.

[0061] The cosmetically acceptable topical carrier may optionally contain a variety of additional oil-soluble and / or oil-dispersible materials that are commonly used in compositions for application to the skin at levels established in the art. For example, surfactants, emulsifiers, pearlescent or opacifying agents, thickeners, emollients, conditioners, humectants, chelating agents, exfoliants, preservatives, pH adjusters, and additives that enhance the appearance, feel, or flavor of the composition, such as colorants, fragrances, tactile enhancers, and the like may be included.

[0062] How to use

[0063] As used herein, "topical application" means spraying, rubbing, applying or spreading directly onto the outer skin or scalp, for example, by hand or with an applicator such as a wipe, roller or sprayer.

[0064] The sunscreen composition can be applied to the user's skin in any desired manner. In some aspects, the product can be applied directly by hand, or a device such as a cotton pad or other tool can be used to apply the product. The composition is advantageously applied to the skin to aid in sample absorption. The composition can be left on the applied area for a desired level of time, such as from about 5 seconds to about 5 minutes. Alternatively, the composition can be left on the applied area and continued to be applied until absorbed.

[0065] The composition of the present invention is sprayable. As used herein, "sprayable" means that when manually actuated or released by pressurization from a dispensing mechanism such as a bottle or aerosol can with a pump spray nozzle, the composition produces a uniformly distributed and reproducible spray pattern over an area of ​​defined shape (e.g., circular, annular) and size. The composition can be sprayable without the use of a propellant, i.e., in a non-aerosol form.

[0066] The present invention is further described below in conjunction with specific examples. It is necessary to point out that the examples are only used to further illustrate the present invention and cannot be construed as limiting the scope of the present invention. Those skilled in the art can make some non-essential improvements and adjustments based on the content of the present invention described above. The test methods in the following examples that do not specify specific conditions are usually based on conventional conditions or the conditions recommended by the manufacturer. Unless otherwise stated, all percentages and parts are by weight.

[0067] Experimental Materials:

[0068] Sunscreen:

[0069] Phenylbenzimidazole sulfonic acid, supplied by Symrise AG (trade name Neo Hydro);

[0070] Bis-ethylhexyloxyphenol methoxyphenyl triazine, acrylates / C12-22 alkyl methacrylate copolymer, arginine, coco-glucoside, disodium lauryl sulfosuccinate, water, provided by BASF (trade name Tinosorb SLite Aqua);

[0071] Bis-ethylhexyloxyphenol methoxyphenyl triazine, supplied by BASF (trade name Tinosorb S)

[0072] Ethylhexyl triazone, supplied by BASF (trade name Uvinul T 150);

[0073] Methylene bis-benzotriazole tetramethylbutylphenol, provided by BASF (trade name Tinosorb M);

[0074] Emulsifier:

[0075] Steareth-21, provided by BASF (trade name Eumulgin S 21);

[0076] C14-22 alcohol / C12-20 alkyl glucoside, supplied by SEPPIC (trade name Montanov L);

[0077] pH Adjuster:

[0078] Tromethamine, supplied by Angus (trade name TRIS AMINO ULTRA PC);

[0079] Thickener:

[0080] Acrylates / vinyl isodecanoate crosspolymer, provided by 3V SIGMA (trade name Stabylen-30);

[0081] grease:

[0082] Dicaprylyl carbonate, supplied by BASF (trade name Cetiol CC);

[0083] Dibutyl adipate, supplied by BASF (trade name Cetiol B);

[0084] Isononyl isononanoate, provided by SEPPIC (trade name LANOL99);

[0085] preservative:

[0086] Phenoxyethanol, supplied by DOW (trade name NEOLONE PH 100 Preservative).

[0087] Example 1: Preparation of sunscreen composition

[0088] 1. Weigh the water phase raw materials: 68.65 parts by mass of deionized water and 0.2 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate crosslinked polymer.

[0089] 2. Weigh the oil phase raw materials: 2.5 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 15 parts by mass of dibutyl adipate, and 2 parts by mass of C14-22 alcohol / C12-20 alkyl glucoside.

[0090] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0091] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0092] 5. Cool down to 60°C, add 0.15 parts by weight of tromethamine, and homogenize for 5 minutes after all the addition is complete.

[0093] 6. Cool down to 45-50°C, add 8 parts by weight of sunscreen Tinosorb S lite Aqua, homogenize for 2-3 minutes after addition, stir and cool to room temperature, and set aside.

[0094] Table 1

[0095]

[0096] Example 2: Preparation of sunscreen composition

[0097] 1. Weigh the water phase raw materials: 70.35 parts by mass of deionized water and 0.2 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate cross-linked polymer.

[0098] 2. Weigh the oil phase raw materials: 0.8 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 15 parts by mass of dibutyl adipate, and 2 parts by mass of emulsifier C14-22 alcohol / C12-20 alkyl glucoside.

[0099] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0100] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0101] 5. Cool down to 60°C, add 0.15 parts by weight of tromethamine, and homogenize for 5 minutes after all the addition is complete.

[0102] 6. Cool down to 45-50°C, add 8 parts by weight of sunscreen Tinosorb S lite Aqua, homogenize for 2-3 minutes after addition, stir and cool to room temperature, and set aside.

[0103] Table 2

[0104]

[0105] Example 3: Preparation of sunscreen composition

[0106] 1. Weigh the water phase raw materials: 67.15 parts by mass of deionized water and 0.2 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate crosslinked polymer.

[0107] 2. Weigh the oil phase raw materials: 4 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 15 parts by mass of dibutyl adipate, and 2 parts by mass of emulsifier C14-22 alcohol / C12-20 alkyl glucoside.

[0108] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0109] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0110] 5. Cool down to 60°C, add 0.15 parts by weight of tromethamine, and homogenize for 5 minutes after all the addition is complete.

[0111] 6. Cool down to 45-50°C, add 8 parts by weight of sunscreen Tinosorb S lite Aqua, homogenize for 2-3 minutes after addition, stir and cool to room temperature, and set aside.

[0112] Table 3

[0113]

[0114] Test Example 1: Stability Test

[0115] The stability of Example 1, Example 2 and Example 3 was compared and investigated.

[0116] Table 4

[0117]

[0118] The samples were placed in room temperature, 4℃ refrigerator, -15℃ refrigerator, high temperature (40℃) thermostat, and high temperature (48℃) thermostat for 2 weeks. The results of the stability test are shown in the following table:

[0119] Table 5

[0120]

[0121] Result: When the emulsifier in the formula was increased to 4%, the high temperature stability of the formula failed.

[0122] Example 4: Preparation of sunscreen composition

[0123] 1. Weigh the water phase raw materials: 68.8 parts by mass of deionized water and 0.1 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate cross-linked polymer.

[0124] 2. Weigh the oil phase raw materials: 2.5 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 15 parts by mass of dibutyl adipate, and 2 parts by mass of emulsifier C14-22 alcohol / C12-20 alkyl glucoside.

[0125] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0126] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0127] 5. Cool down to 60°C, add 0.1 parts by weight of tromethamine, and homogenize for 5 minutes after all the addition is complete.

[0128] 6. Cool down to 45-50°C, add 8 parts by weight of sunscreen Tinosorb S lite Aqua, homogenize for 2-3 minutes after addition, stir and cool to room temperature, and set aside.

[0129] Table 6

[0130]

[0131] Test Example 2: Comparison of centrifugal stability at different polymer contents

[0132] Table 7

[0133]

[0134] The above two samples were placed in a centrifuge (Feige low-speed centrifuge TDL-80-2C) for testing under the following test conditions: 2500 rpm, 30 mins.

[0135] Results: Example 4 had stratification at the bottom under centrifugation (2500 rpm, 30 mins), while Example 1 remained stable. This indicates that the content of the cross-linked polymer of acrylic acid (ester) / vinyl isodecanoate should not be less than 0.2%.

[0136] The following experiment compares the water-dispersible sunscreen agent Tinosorb S Lite Aqua and Phenylbenzimidazole Sulfonic Acid in the Formula Performance in:

[0137] Example 5: Preparation of sunscreen composition

[0138] 1. Weigh the water phase raw materials: 58.6 parts by mass of deionized water and 0.2 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate crosslinked polymer.

[0139] 2. Weigh the oil phase raw materials: 2.5 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 15 parts by mass of dibutyl adipate, 2 parts by mass of emulsifier C14-22 alcohol / C12-20 alkyl glucoside, 1 part by mass of isononyl isononanoate, 2 parts by mass of sunscreen bis-ethylhexyloxyphenol methoxyphenyl triazine, and 3 parts by mass of ethylhexyl triazone.

[0140] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0141] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0142] 5. Cool down to 60°C, add 0.2 parts by mass of tromethamine, and homogenize for 5 minutes after all the addition. 5. Cool down to 45-50°C, add 8 parts by mass of sunscreen Tinosorb S lite Aqua, and homogenize for 2-3 minutes after adding. Stir and cool to room temperature, then add 9 parts by mass of Tinosorb M, stir evenly and set aside.

[0143] Table 8

[0144]

[0145] Example 6: Preparation of sunscreen composition

[0146] 1. Weigh the water phase raw materials: 64.9 parts by mass of deionized water and 0.2 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate cross-linked polymer.

[0147] 2. Weigh the oil phase raw materials: 2.5 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 15 parts by mass of dibutyl adipate, 2 parts by mass of emulsifier C14-22 alcohol / C12-20 alkyl glucoside, 1 part by mass of isononyl isononanoate, 2 parts by mass of sunscreen bis-ethylhexyloxyphenol methoxyphenyl triazine, and 3 parts by mass of ethylhexyl triazone.

[0148] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0149] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0150] 5. Cool down to 60°C, add 0.3 parts by weight of tromethamine, and homogenize for 5 minutes after all the addition is complete.

[0151] 6. Cool down to 45-50°C, add 1.6 parts by weight of sunscreen phenylbenzimidazole sulfonic acid, homogenize for 3 minutes after addition, stir and cool to room temperature, then add 9 parts by weight of Tinosorb M, stir evenly and set aside.

[0152] Table 9

[0153]

[0154] Note: The content of sunscreen agent bis-ethylhexyloxyphenol methoxyphenyl triazine in Tinosorb S Lite Aqua raw material is 20%, and phenylbenzimidazole sulfonic acid is 100% pure substance.

[0155] Test Example 3: Thermal Shake Test Stability

[0156] Example 5 and Example 6 were subjected to a thermal shaking test (constant temperature shaker THZ-D) at 38° C., 200 rpm, for 24 hours.

[0157] Results: Example 6 separated and released oil under hot shaking, while Example 5 remained stable, indicating that Tinosorb S LiteAqua was more stable than phenylbenzimidazole sulfonic acid when used in the formulation.

[0158] Test Example 4: SPF value

[0159] Table 10

[0160] Example 5 Example 6 SPF (theoretical calculation value) 34.5 36.3 SPF (machine test) 62.3 45.9

[0161] SPF machine testing equipment: SPF290S analysis system (Optomet-rics, USA)

[0162] The SPF values ​​of the two formulas were measured by SPF290S. It was found that when the amount of sunscreen added was the same, the sun protection index of Example 5 was significantly higher than that of Example 6. According to the calculated SPF values ​​(DSM online calculator), the calculated values ​​of Example 5 and Example 6 were 34.5 and 36.3, respectively, which were very close. This shows that Tinosorb S Lite Aqua has a higher sun protection efficiency in this formula, and has a synergistic effect with other sunscreen ingredients in the formula, and its effect is higher than that of the comparative example phenylbenzimidazole sulfonic acid.

[0163] Therefore, it is found from the above Test Examples 3 and 4 that when Tinosorb S Lite Aqua is used in this formula, it not only has good stability but also has high sun protection efficiency.

[0164] The following experiment compared the sunscreen Tinosorb S Lite Aqua different dosage:

[0165] Example 7: Preparation of sunscreen composition

[0166] 1. Weigh the water phase raw materials: 68.25 parts by mass of deionized water, 0.2 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate cross-linked polymer, 4 parts by mass of moisturizer butylene glycol, and 0.35 parts by mass of preservative phenoxyethanol.

[0167] 2. Weigh the oil phase raw materials: 2.5 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 10 parts by mass of dibutyl adipate, 2 parts by mass of emulsifier C14-22 alcohol / C12-20 alkyl glucoside, 2 parts by mass of sunscreen bis-ethylhexyloxyphenol methoxyphenyl triazine, 3 parts by mass of sunscreen ethylhexyl triazone, and 1 part by mass of isononyl isononanoate.

[0168] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0169] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0170] 5. Cool down to 60°C, add 0.2 parts by weight of tromethamine, and homogenize for 5 minutes after all the addition is complete.

[0171] 6. Cool down to 45-50°C, add 3 parts by weight of sunscreen Tinosorb S lite Aqua, homogenize for 3 minutes after adding, stir and cool to room temperature, and set aside.

[0172] Table 11

[0173]

[0174] Example 8: Preparation of sunscreen composition

[0175] 1. Weigh the water phase raw materials: 65.25 parts by mass of deionized water, 0.2 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate cross-linked polymer, 4 parts by mass of moisturizer butylene glycol, and 0.35 parts by mass of preservative phenoxyethanol.

[0176] 2. Weigh the oil phase raw materials: 2.5 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 10 parts by mass of dibutyl adipate, 2 parts by mass of emulsifier C14-22 alcohol / C12-20 alkyl glucoside, 2 parts by mass of sunscreen bis-ethylhexyloxyphenol methoxyphenyl triazine, 3 parts by mass of sunscreen ethylhexyl triazone, and 1 part by mass of isononyl isononanoate.

[0177] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0178] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0179] 5. Cool down to 60°C, add 0.12 parts by weight of tromethamine, and homogenize for 5 minutes after all the addition is complete.

[0180] 6. Cool down to 45-50°C, add 6 parts by weight of sunscreen Tinosorb S lite Aqua, homogenize for 3 minutes after adding, stir and cool to room temperature, and set aside.

[0181] Table 12

[0182]

[0183] Example 9: Preparation of sunscreen composition

[0184] 1. Weigh the water phase raw materials: 62.25 parts by mass of deionized water, 0.2 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate cross-linked polymer, 0.35 parts by mass of preservative phenoxyethanol, and 4 parts by mass of moisturizer butylene glycol.

[0185] 2. Weigh the oil phase raw materials: 2.5 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 10 parts by mass of dibutyl adipate, 2 parts by mass of emulsifier C14-22 alcohol / C12-20 alkyl glucoside, 2 parts by mass of sunscreen bis-ethylhexyloxyphenol methoxyphenyl triazine, 3 parts by mass of sunscreen ethylhexyl triazone, and 1 part by mass of isononyl isononanoate.

[0186] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0187] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0188] 5. Cool down to 60°C, add 0.2 parts by weight of tromethamine, and homogenize for 5 minutes after all the addition is complete.

[0189] 6. Cool down to 45-50°C, add 9 parts by weight of sunscreen Tinosorb S lite Aqua, homogenize for 3 minutes after addition, stir and cool to room temperature, and set aside.

[0190] Table 13

[0191]

[0192] Example 10: Preparation of sunscreen composition

[0193] 1. Weigh the water phase raw materials: 59.25 parts by mass of deionized water, 0.2 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate cross-linked polymer, 0.35 parts by mass of preservative phenoxyethanol, and 4 parts by mass of moisturizer butylene glycol.

[0194] 2. Weigh the oil phase raw materials: 2.5 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 10 parts by mass of dibutyl adipate, 2 parts by mass of emulsifier C14-22 alcohol / C12-20 alkyl glucoside, 2 parts by mass of sunscreen bis-ethylhexyloxyphenol methoxyphenyl triazine, 3 parts by mass of sunscreen ethylhexyl triazone, and 1 part by mass of isononyl isononanoate.

[0195] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0196] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0197] 5. Cool down to 60°C, add 0.2 parts by weight of tromethamine, and homogenize for 5 minutes after all the addition is complete.

[0198] 6. Cool down to 45-50°C, add 12 parts by weight of sunscreen Tinosorb S lite Aqua, homogenize for 3 minutes after addition, stir and cool to room temperature, and set aside.

[0199] Table 14

[0200]

[0201] Example 11: Preparation of sunscreen composition

[0202] 1. Weigh the water phase raw materials: 56.25 parts by mass of deionized water, 0.2 parts by mass of thickener acrylic acid (ester) / vinyl isodecanoate cross-linked polymer, 0.35 parts by mass of preservative phenoxyethanol, and 4 parts by mass of moisturizer butylene glycol.

[0203] 2. Weigh the oil phase raw materials: 2.5 parts by mass of emulsifier steareth-21, 3.5 parts by mass of dicaprylyl carbonate, 10 parts by mass of dibutyl adipate, 2 parts by mass of emulsifier C14-22 alcohol / C12-20 alkyl glucoside, 2 parts by mass of sunscreen bis-ethylhexyloxyphenol methoxyphenyl triazine, 3 parts by mass of sunscreen ethylhexyl triazone, and 1 part by mass of isononyl isononanoate.

[0204] 3. The water phase and oil phase are dissolved and dispersed in a water bath at 80-85°C.

[0205] 4. Under homogenization at 80-85℃, slowly add the oil phase into the water phase and homogenize for 5 minutes after all the addition is completed.

[0206] 5. Cool down to 60°C, add 0.2 parts by weight of tromethamine, and homogenize for 5 minutes after all the addition is complete.

[0207] 6. Cool down to 45-50°C, add 15 parts by weight of sunscreen Tinosorb S lite Aqua, homogenize for 3 minutes after addition, stir and cool to room temperature for later use.

[0208] Table 15

[0209]

[0210] Test Example 5: Thermal Centrifugation

[0211] When Example 7, Example 8, Example 9, Example 10 and Example 11 were subjected to accelerated stability testing using hot centrifugation (LUMiSizer, centrifugation at 4000 rpm for 25 mins at 48 degrees), stratification was found in Examples 10 and 11, indicating that the amount of Tinosorb S Lite Aqua added in the formula should not exceed 12%.

[0212] The following experiment describes Tinosorb S Lite Aqua in oil-gel sunscreen formulas:

[0213] Experimental Materials:

[0214] grease:

[0215] Dicaprylyl carbonate, supplied by BASF (trade name Cetiol CC)

[0216] Polydimethylsiloxane, supplied by Wacker (trade name Belsil DM 1 PLUS)

[0217] Thickener:

[0218] Silica dimethyl silylate, supplied by WACKER (trade name HDK H20)

[0219] Sunscreen:

[0220] Bis-ethylhexyloxyphenol methoxyphenyl triazine, acrylates / C12-22 alkyl methacrylate copolymer, arginine, coco-glucoside, disodium lauryl sulfosuccinate, water, provided by BASF (trade name Tinosorb SLite Aqua);

[0221] Example 12: Preparation of sunscreen composition

[0222] 1. Weigh the oil phase raw materials: 33 parts by mass of dicaprylyl carbonate, 4 parts by mass of fumed silica, and 60 parts by mass of polydimethylsiloxane, and stir for 10 minutes.

[0223] 2. Add 3 parts by mass of Tinosorb S lite Aqua into the above material and stir for 5 minutes.

[0224] Table 16

[0225]

[0226] Example 13: Preparation of sunscreen composition

[0227] 1. Weigh the oil phase raw materials: 30 parts by mass of dicaprylyl carbonate, 4 parts by mass of fumed silica, and 60 parts by mass of polydimethylsiloxane, and stir for 10 minutes.

[0228] 2. Add 6 parts by mass of Tinosorb S lite Aqua to the above material and stir for 5 minutes.

[0229] Table 17

[0230]

[0231] Example 14: Preparation of sunscreen composition

[0232] 1. Weigh the oil phase raw materials: 26 parts by mass of dicaprylyl carbonate, 4 parts by mass of fumed silica, and 60 parts by mass of polydimethylsiloxane, and stir for 10 minutes.

[0233] 2. Add 10 parts by mass of Tinosorb S lite Aqua into the above material and stir for 5 minutes.

[0234] Table 18

[0235]

[0236] Test Example 6: Stability Study

[0237] The samples of Examples 12, 13, and 14 were subjected to stability tests. They were placed in room temperature, a 4°C refrigerator, a -15°C refrigerator, a high temperature (40°C) thermostat, and a high temperature (48°C) thermostat for 2 weeks. The results of the stability tests are shown in the following table:

[0238] Table 19

[0239]

[0240] Tinosorb S lite Aqua is a water-dispersible sunscreen suitable for hydrophilic systems. The present invention finds that it can also be used in oil gel systems, and it is added to the pure oil system by a suspension stabilization method and remains stable. The above application formulas can produce oil gel sunscreen with light skin feel, and the process is simple and convenient.

[0241] Application Examples

[0242] Application scenarios: sunscreen for adults, sunscreen lotion, sunscreen spray

[0243] Application Example 1: Preparation of Sunscreen for Adults

[0244]

[0245]

[0246] Process: Heat phase A to 80℃, disperse evenly under homogenization and add phase B heated to 80℃, homogenize for 5 minutes after addition, cool to 50℃ with stirring, add phase C, cool to 45℃ with stirring, add phase D, homogenize for 3 minutes after addition, stir and cool to 35℃.

[0247] Application Example 2: Preparation of Sunscreen Lotion for Adults

[0248]

[0249] Process: Heat phase A to 80℃, disperse evenly under homogenization and add phase B heated to 80℃, homogenize for 5 minutes after addition, cool to 50℃ with stirring, add phase C, cool to 45℃ with stirring, add phase D, homogenize for 3 minutes after addition, stir and cool to 35℃.

[0250] Application Example 3: Preparation of Sunscreen Spray for Adults

[0251]

[0252] Process: Heat phase A to 80℃, disperse evenly under homogenization and add phase B heated to 80℃, homogenize for 5 minutes after addition, cool to 50℃ with stirring, add phase C, cool to 45℃ with stirring, add phase D, homogenize for 3 minutes after addition, stir and cool to 35℃.

Claims

1. A sunscreen composition comprising a water-dispersible sunscreen agent, the composition being in the form of an oil gel, comprising: 2-12 wt. % Tinosorb S Lite Aqua; 0.2-5 wt% of a thickener, the thickener being silica dimethyl silylate; and grease.

2. The sunscreen composition according to claim 1, wherein The oil is selected from: dicaprylyl carbonate, polydimethylsiloxane or a combination thereof.

3. Use of the sunscreen composition according to claim 1 or 2 in the preparation of sunscreen products, wherein the sunscreen products are selected from the following forms: sunscreen cream for adults, sunscreen lotion for adults, sunscreen spray for adults, sunscreen lotion for infants and young children, and sunscreen spray for infants and young children.

Images