Fully automatic homogeneous chemiluminescence instant detection analyzer

Abstract

The application provides a full-automatic homogeneous chemiluminescence instant detection analyzer, which comprises a base, which is provided with a sample tube supply device with a plurality of sample tubes, a Tip head batch loading device, a reagent strip supply device, a reagent strip storage bin for storing a plurality of reagent strips and a reagent strip grabbing device capable of grabbing and transferring the reagent strips; a reaction disc mechanism with a plurality of reagent strip placing positions extending along the diameter direction thereof; and a liquid taking device capable of being assembled with a Tip head group delivered by the Tip head batch loading device, capable of taking samples in the sample tubes delivered by the sample tube supply device and reagents in reagent holes of the reagent strips on the reagent strip placing positions of the reaction disc assembly, and capable of placing the samples and / or the reagents into detection holes of the same reagent strips. The application greatly simplifies the instant detection process, realizes batch online loading of consumables, reagents and samples, has high automation degree, meets batch detection requirements, can realize unattended operation, and reduces labor cost.

Description

Technical Field

[0001] This invention belongs to the field of immunodiagnostic technology, specifically relating to a fully automated homogeneous chemiluminescence real-time detection and analysis instrument. Background Technology

[0002] Currently, most point-of-care testing (POCT) instruments on the market that use single-sample in vitro diagnostics typically employ a single-sample or small-batch reagent loading method (which cannot achieve fully automated continuous loading of original tube samples, reagents, and consumables). Furthermore, the operation mode is to complete one round of testing before starting the next round, which greatly limits the testing throughput. To achieve high throughput and online loading of original tube samples, reagents, and consumables, the instrument would have to be bulky (large size is inconvenient for clinical use), have a complex structure (complex structure leads to poor stability and a high failure rate), and be more expensive (large instruments have high material and labor costs). Summary of the Invention

[0003] Therefore, the technical problem to be solved by the present invention is to provide a fully automated homogeneous chemiluminescence real-time detection and analysis instrument, which greatly simplifies the real-time detection process, enables batch online loading of consumables, reagents and samples, has a high degree of automation to meet the needs of batch detection, and can achieve unmanned operation, thus reducing labor costs.

[0004] To address the aforementioned problems, this invention provides a fully automated homogeneous chemiluminescence real-time detection and analysis instrument, comprising a base on which:

[0005] A sample tube supply device containing multiple sample tubes;

[0006] A tip head batch loading device, which contains multiple tip heads;

[0007] A reagent strip supply device includes a reagent strip compartment for storing multiple reagent strips and a reagent strip gripping device capable of gripping and transferring the reagent strips;

[0008] The reaction disk mechanism includes a reaction disk assembly that can be driven to rotate, having multiple reagent strip placement positions extending along its diameter.

[0009] The liquid collection device is capable of assembling with a tip head delivered by the tip head batch loading device, and drawing up the sample from the sample tube delivered by the sample tube supply device and the reagent from the reagent hole of the reagent strip located at the reagent strip placement position of the reaction plate assembly, and placing the sample and / or reagent into the detection hole of the same reagent strip.

[0010] The homogeneous chemiluminescence immunoassay module can collect the luminescence information of the reaction solution in the detection well of the reagent strip at the detection position.

[0011] In some embodiments, the sample tube supply device includes:

[0012] A sample rack holder for placing the sample tubes has a sample rack slide for placing the sample rack, and a through groove is formed on the bottom wall of the sample rack slide.

[0013] A sample rack supply drive assembly is used to drive the sample rack to slide back and forth along the extension direction of the sample rack slide.

[0014] In some implementations...

[0015] The sample rack supply drive component includes:

[0016] A connecting component for selectively connecting to the sample holder;

[0017] A first sliding drive component is used to drive the connecting component to slide back and forth along the extension direction of the sample holder slide.

[0018] The sample rack placement component has multiple sample rack slides, and the connecting assembly can be controlled to move between the multiple sample rack slides to achieve selective connection of the sample racks placed in different sample rack slides.

[0019] In some implementations...

[0020] The sample holder has a claw groove on its bottom outer wall. The connecting assembly includes a first lead screw motor and a claw connected to the end of the first lead screw of the first lead screw motor. The first lead screw motor can drive the claw to move toward or away from the sample holder so that the claw engages with or disengages from the claw groove; and / or,

[0021] The first sliding drive assembly includes a first guide rail and a first rotary motor arranged along the extension direction of the sample rack slide. The first rotary motor can drive the connecting assembly to slide back and forth along the first guide rail.

[0022] In some implementations...

[0023] The sample rack placement component has multiple sample rack slides, and the connecting assembly can be controlled to move between the multiple sample rack slides to achieve selective connection of the sample racks placed in different sample rack slides.

[0024] In some implementations...

[0025] It also includes a second sliding drive component, which is capable of driving the connecting component to move between the plurality of sample rack slides, and the first sliding drive component is also capable of driving the connecting component and the second sliding drive component as a whole to slide back and forth along the extension direction of the sample rack slide.

[0026] In some implementations...

[0027] A photoelectric switch is provided at a first position and a through-beam sensor is provided at a second position for each of the sample rack slides. The photoelectric switch and the through-beam sensor are configured in pairs to ensure that the two ends of the sample rack can be positioned at the first position and the second position respectively; or...

[0028] The liquid collection device includes a liquid collection head, the movement of which is limited to a first plane containing the X and Z axes. The target sample tube of the sample holder can be fed along the Y-axis direction to the position below the liquid collection head where the Y-axis intersects the first plane under the action of the sample holder supply drive assembly.

[0029] In some embodiments, the tip header bulk loading device includes:

[0030] Consumable assembly, including a tray and a plurality of the tip heads located on the tray;

[0031] The consumables rack includes opposing side plates and a platform located at the upper part of one end of the corresponding length of the two side plates. A feeding guide rail is formed on the opposite side of the two side plates, and the pallet is slidably connected to the feeding guide rail.

[0032] The feeding drive component is capable of transferring the consumable assembly from a first position to a second position along the feeding track, and is capable of transferring the consumable assembly with the tip head depleted from the second position to the platform, wherein the first position and the second position correspond to the two ends of the length direction of the side plate, respectively.

[0033] In some implementations...

[0034] A switching plate is provided between each side plate and the platform. The top end of the switching plate is pivotally connected to the platform, and the bottom end of the switching plate contacts and connects to the top surface of the side plate under its own weight. The switching plate is inclined to the horizontal plane to facilitate the transfer of the consumable component from the first position to the second position and from the second position to the platform.

[0035] In some implementations...

[0036] The angle of inclination between the switching plate and the horizontal plane is α, where 10°≤a≤60°.

[0037] In some embodiments, the feed drive component includes:

[0038] A linear reciprocating drive component and a push-pull assembly, wherein the push-pull assembly is used to apply force to the consumable component, and the linear reciprocating drive component is used to drive the push-pull assembly to generate linear reciprocating motion along the extension direction of the feed guide rail.

[0039] In some implementations...

[0040] The push-pull assembly includes a baffle deflection motor, on which a baffle is connected. The baffle deflection motor can drive the baffle to switch between its initial position and the push-pull position.

[0041] In some implementations...

[0042] The baffle is provided with a groove, and when the consumable component needs to be transferred from the first position to the second position, the vertical wall of the tray is partially inserted into the groove; and / or, when the consumable component needs to be transferred from the second position to the platform, the side end face of the baffle away from the baffle deflection motor abuts against the vertical wall of the tray.

[0043] In some implementations...

[0044] The linear reciprocating drive component includes a rotary motor, the push-pull assembly also includes a fixed frame, the baffle deflection motor is mounted on the fixed frame, and the rotary motor is drivenly connected to the fixed frame through a belt transmission structure.

[0045] In some implementations...

[0046] The rotary motor is located on the inner side of one of the two side plates, and the belt conveyor structure is located on the outer side of the side plate. The belt conveyor structure includes a pulley mounted on the shaft of the rotary motor, support rollers spaced apart from the pulley on a straight reciprocating path, and a conveyor belt mounted on the pulley and the support rollers. The conveyor belt is fixedly connected to the fixed frame. Alternatively, the fixed frame is provided with a first sensor for detecting the initial position of the baffle.

[0047] In some embodiments, the reagent strip gripping device includes:

[0048] Installation components;

[0049] The gripper unit includes two gripper arms arranged opposite to each other;

[0050] The gripping device drive component is mounted on the mounting component and can drive the two gripper arms to move towards or away from each other to form a gripping of the two opposite sidewalls of the reagent strip. After the gripper arms grip the reagent strip, the gripper unit can be driven to rise in a straight line.

[0051] The lateral drive component is capable of simultaneously translating the mounting component, gripper unit, and grasping device drive component along a horizontal straight line.

[0052] In some implementations...

[0053] The gripper unit further includes a gripper rotating mounting plate, which is fixedly connected to the mounting component. Two gripper arms are pivotally connected to the gripper rotating mounting plate, and one corresponding end of each gripper arm is also pivotally connected to a reciprocating slider. The reciprocating slider is connected to the power output shaft of the gripping device drive component. When the power output shaft moves close to the gripper arm, the two gripper arms move away from each other. When the power output shaft moves away from the gripper arm, the two gripper arms move towards each other. And / or, a locking strip is provided on the opposite side of each of the two gripper arms.

[0054] In some implementations...

[0055] The reciprocating slider has a horizontally extending groove, and the corresponding end of the gripper arm is slidably connected to the groove via a bearing; or,

[0056] The gripping device drive component includes a lead screw motor, the power output shaft is the lead screw of the lead screw motor, the mounting component is also provided with a guide rail, and the reciprocating slider is slidably connected to the guide rail.

[0057] In some implementations...

[0058] A first photoelectric sensor is provided near the end of the lead screw away from the gripper unit to detect the position of the lead screw.

[0059] In some implementations...

[0060] The gripper unit also includes a reagent strip pressure application component, which can apply force to the reagent strip when the gripper unit clamps or releases the reagent strip.

[0061] In some implementations...

[0062] The reagent strip pressure assembly includes a force-applying column, which is slidably inserted into the gripper rotating mounting plate. The end of the force-applying column facing the reagent strip is a force-applying disk, and an elastic element is clamped between the force-applying disk and the gripper rotating mounting plate.

[0063] In some implementations...

[0064] The end of the force-applying column away from the reagent strip has a U-shaped component, and the gripper rotating mounting plate is at least partially located within the opening area of ​​the U-shaped component; and / or, the end of the force-applying column away from the reagent strip has a detection piece, and a second photoelectric sensor is provided corresponding to the detection piece, the second photoelectric sensor being used to detect the position of the force-applying column.

[0065] In some implementations...

[0066] The reagent strip pressure application assembly has two sets, and the two sets of reagent strip pressure application assemblies are respectively located at both ends of the length direction of the gripper rotating mounting plate. The two ends of the length direction of the gripper rotating mounting plate correspond to the two ends of the length direction of the reagent strip. There are two second photoelectric sensors, and the two second photoelectric sensors are respectively set at both ends of the length direction of the gripper rotating mounting plate.

[0067] In some embodiments, the reaction disk mechanism further includes:

[0068] The mounting base includes a top plate and two relatively parallel and spaced side plates. The two side plates have a first slot on their opposite side walls, and the top plate is inserted into the first slot.

[0069] The reaction disk assembly is mounted entirely on the top plate.

[0070] In some implementations...

[0071] The mounting base also includes a rear upright plate connected to one end of the two side upright plates and a front upright plate detachably connected to the other end of the side upright plates.

[0072] In some implementations...

[0073] The inner wall of the rear upright plate has a second slot corresponding to the first slot, and / or the inner wall of the front upright plate has a third slot corresponding to the first slot; or, the rear upright plate and / or the front upright plate are bolted to the side upright plate by threaded parts.

[0074] In some implementations...

[0075] The reaction disk assembly includes a base, a toothed ring on the side of the base facing the top plate, a first photoelectric switch on the outer side of the toothed ring, the first photoelectric switch being able to sense the teeth of the toothed ring to determine the rotational angular displacement of the base; and / or, a second photoelectric switch on the inner side of the toothed ring, the second photoelectric switch being able to sense a photoelectric baffle located on the inner side of the toothed ring to determine the initial rotational position of the base.

[0076] In some implementations...

[0077] The reaction plate assembly also includes an incubation plate and a heating plate located between the substrate and the incubation plate. The substrate has multiple reagent strip placement positions extending radially therefrom. The incubation plate has multiple incubation holes. The positions of the incubation holes correspond one-to-one with the positions of the detection holes of the reagent strips placed on the reagent strip placement positions. The incubation holes are made of the same material as the incubation plate and are integrally formed.

[0078] In some embodiments, the liquid collection device includes a liquid collection unit, the liquid collection unit comprising:

[0079] The liquid extraction mounting component has a sealed cavity inside.

[0080] A liquid-collecting head is connected to a through hole in the sealed cavity and can be assembled with the tip head;

[0081] The piston rod is disposed in the sealed cavity and, driven by the reciprocating drive component, realizes the liquid suction and discharge functions of the liquid-taking head;

[0082] The telescopic rod of the reciprocating drive component is magnetically connected to the piston rod.

[0083] In some implementations...

[0084] The telescopic rod has a first magnet at one end facing the piston rod, and the piston rod has a second magnet at one end facing the telescopic rod; and / or, the telescopic rod is a motor lead screw.

[0085] In some implementations...

[0086] An adapter is connected to one end of the telescopic rod facing the piston rod, and the first magnet is connected to one end of the telescopic rod through the adapter.

[0087] In some implementations...

[0088] A guide assembly is provided between the adapter and the liquid extraction mounting component. The guide assembly includes a pin fixedly connected to the adapter and a bearing fitted on the pin.

[0089] In some implementations...

[0090] A limiting structure is also provided between the piston rod and the telescopic rod.

[0091] In some implementations...

[0092] The extension and retraction direction of the piston rod is perpendicular to the flow direction of the liquid collection head; and / or, it also includes a lifting drive unit, which is drivenly connected to the liquid collection unit.

[0093] In some implementations...

[0094] The lifting drive unit includes a lead screw motor, a slide rail, and a slider connector. The slider connector and the liquid collection mounting component are both slidably connected to the slide rail and can be lifted and lowered along the slide rail under the drive of the lead screw of the lead screw motor. The slider connector and the liquid collection mounting component are connected by a connecting shaft.

[0095] In some implementations...

[0096] One end of the connecting shaft is located inside the liquid-collecting mounting component and can slide. A spring is fitted on the connecting shaft to apply force to the liquid-collecting mounting component when the slider connector descends, and to allow the liquid-collecting mounting component to move toward the slider connector when the liquid-collecting head touches the bottom.

[0097] In some embodiments, the homogeneous chemiluminescence immunoassay module includes:

[0098] The detection assembly includes a detection head that can be driven to rise and fall.

[0099] A light-dense component assembly includes a light-dense component that can switch between a first position and a second position. When the light-dense component is in the first position, it enables the light-transmitting structure of the detection head to achieve light-dense operation. When the light-dense component is in the second position, the light-dense structure of the reagent strip corresponding to the detection head enables the light-transmitting structure of the detection head to achieve light-dense operation.

[0100] In some implementations...

[0101] The detection head is detachably connected to a light-dense adhesive pad on the side facing the reagent strip; and / or,

[0102] The detection head is provided with a pressure strip on the side facing the reagent strip. When the light-dense structure of the reagent strip dazzles the light-transmitting structure of the detection head, the pressure strip can press against the top surface of the reagent strip and undergo elastic deformation.

[0103] In some implementations...

[0104] It also includes a lifting drive assembly for driving the detection head to reciprocate linearly toward or away from the reagent strip; and / or,

[0105] It also includes a swing drive assembly for driving the light-diffusing element to switch between the first position and the second position.

[0106] In some implementations...

[0107] The light-diffusing component is equipped with support rollers, which allow it to slide on a corresponding support carrier.

[0108] In some implementations...

[0109] The support rollers are in two sets, and the two sets of support rollers are arranged on opposite sides of the light-diffusing component.

[0110] In some embodiments, the fully automated homogeneous chemiluminescence real-time detection and analysis instrument further includes:

[0111] The receiving unit is used to receive abnormal reagent strips picked up by the reagent strip grabbing device.

[0112] This invention provides a fully automated homogeneous chemiluminescence real-time detection analyzer, which is equipped with a sample tube supply device with multiple sample tubes, a tip head batch loading device with multiple tip heads, and a reagent strip supply device with multiple reagent strips. The positional changes of the sample tubes, tip heads, and reagent strips in each step of the real-time detection process are achieved by translation in the parallel plane of the liquid dispensing device and the reagent strip grasping device, and rotation in the rotational plane of the reaction disk mechanism. This greatly simplifies the real-time detection process, enables batch online loading of consumables, reagents, and samples, has a high degree of automation to meet the needs of continuous detection and batch loading, and can achieve unmanned operation, reducing labor costs. Attached Figure Description

[0113] Figure 1 This is a three-dimensional structural schematic diagram of the fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to an embodiment of the present invention;

[0114] Figure 2 for Figure 1 A schematic diagram of the sample tube supply device (partially disassembled);

[0115] Figure 3 for Figure 1 A schematic diagram of the sample tube supply device (in the assembled state, the sample rack shown by the dotted line in the figure is the sample rack in the supplied state, and only one sample rack is placed in the same sample rack slide).

[0116] Figure 4 for Figure 2 A three-dimensional structural diagram of the sample holder in the image;

[0117] Figure 5 for Figure 1 A schematic diagram showing the relative positions of the sample tube supply device and the liquid collection device in the diagram.

[0118] Figure 6 for Figure 1 A three-dimensional structural diagram of the Tip header batch loading device;

[0119] Figure 7 for Figure 6 A schematic diagram showing the connection between the baffle and the tray via a groove in the Tip head batch loading device.

[0120] Figure 8 for Figure 6 A schematic diagram showing the state in which the outer end face of the baffle in the Tip head batch loading device is in contact with the tray;

[0121] Figure 9 for Figure 1 A three-dimensional structural diagram of the reagent strip gripping device in the image;

[0122] Figure 10 for Figure 9 A front view schematic diagram of the reagent strip gripping device.

[0123] Figure 11 for Figure 1 A schematic diagram of the reaction disk mechanism (in its assembled state);

[0124] Figure 12 for Figure 1 A schematic diagram of the reaction disk mechanism (partially disassembled);

[0125] Figure 13 for Figure 1 A schematic diagram of the liquid extraction device in the diagram;

[0126] Figure 14 for Figure 13 A magnified view of point A in the diagram;

[0127] Figure 15 for Figure 1 A schematic diagram of the structure of the homogeneous chemiluminescence immunoassay module when the light-dense element is in the first position (detection head not lowered);

[0128] Figure 16 for Figure 1 A schematic diagram of the structure of the homogeneous chemiluminescence immunoassay module when the light-dense element is in the second position (detection head not lowered);

[0129] Figure 17 For Figure 1 A three-dimensional structural diagram of the reagent strip compartment.

[0130] The reference numerals in the attached figures are as follows:

[0131] 1. Sample tube supply device; 11. Sample rack placement component; 111. Sample rack slide; 112. Through slot; 12. Sample rack; 121. Claw slot; 122. Sample tube adapter; 1311. First lead screw motor; 1312. Claw; 1321. First guide rail; 1322. First rotary motor; 1331. Second guide rail; 1332. Second rotary motor; 141. Photoelectric switch; 142. Through-beam sensor; 2. Tip head batch loading device; 211. Tray; 212. Tip head; 221. Side plate; 222. Platform; 23. Switching plate; 241. Baffle deflection motor; 242. Baffle; 2421. Insertion slot; 243. Rotary motor; 244. Fixing frame; 245. Pulley; 246. 247. Support roller; 248. Conveyor belt; 249. Linear guide rail; 240. First sensor; 3. Reagent strip compartment; 31. Reagent rack; 32. Reagent strip feed channel; 33. Feed drive device; 4. Reagent strip gripping device; 41. Mounting component; 411. Guide rail; 421. Gripper arm; 4211. Bearing; 4212. Clamping strip; 4213. Bearing pin; 422. Gripper rotating mounting plate; 423. Reciprocating slider; 4231. Slide groove; 4241. Force application column; 4242. Force application plate; 4243. Elastic element; 4244. U-shaped element; 4245. Detection plate; 43. Screw motor; 441. First photoelectric sensor; 442. Second photoelectric sensor; 5. Reaction disk mechanism; 51. Reaction disk assembly; 511. 512. Base plate; 513. Gear ring; 514. Incubation plate; 515. Incubation hole; 516. Heating plate; 517. Insulation cover plate; 518. Rotating shaft assembly; 529. Top plate; 520. Side upright plate; 5221. First slot; 521. Rear upright plate; 522. Front upright plate; 531. First photoelectric switch; 532. Second photoelectric switch; 541. Rotary motor; 542. Belt drive component; 55. Reagent strip in-situ detection component; 6. Liquid dispensing device; 611. Liquid dispensing mounting component; 612. Liquid dispensing head; 613. Piston rod; 6131. ​​Sealing ring; 6132. Sealing ring lock nut; 6141. First magnet; 6142. Second magnet; 615. Adapter; 6151. Pin; 6152. Bearing; 616. Limit Position structure; 62. Reciprocating drive component; 631. Lead screw motor; 632. Slide rail; 633. Slider connector; 634. Lead screw; 635. Connecting shaft; 636. Spring; 641. Photoelectric baffle; 642. Photoelectric sensor; 7. Homogeneous chemiluminescence immunoassay module; 711. Light-dense component; 712. Support roller; 713. Oscillating drive motor; 721. Light-dense pad; 722. Pressure strip; 723. Module fixing component; 724. Detection module lead screw motor; 725. Baffle; 726. Linear shaft; 727. Elastic component; 728. Photoelectric switch; 731. Detection head fixing component; 732. Laser fixing component; 733. Laser; 734. Photomultiplier tube assembly; 8. Handling unit; 9. Control box;90. Reagent strip; 100. Base. Detailed Implementation

[0132] See also Figures 1 to 17 As shown, the present invention provides a fully automated homogeneous chemiluminescence instantaneous detection and analysis instrument, including a base 100, on which are arranged: a sample tube supply device 1, which has multiple sample tubes; a tip head batch loading device 2, which has multiple tip heads 212; a reagent strip supply device, including a reagent strip compartment 3 for storing multiple reagent strips and a reagent strip gripping device 4 capable of gripping and transferring the reagent strips; a reaction disk mechanism 5, including a reaction disk assembly 51 capable of being driven to rotate, which has multiple reagent strip placement positions extending along its diameter direction, and understandably also has an incubation mechanism; a liquid extraction device 6, which can be assembled with a tip head 212 delivered by the tip head batch loading device 2, and extract the sample from the sample tube delivered by the sample tube supply device 1 and the reagent from the reagent hole of the reagent strip at the reagent strip placement position of the reaction disk assembly 51, and place the sample and / or reagent into the detection hole of the same reagent strip; and a homogeneous chemiluminescence immunoassay module 7, which can collect the luminescence information of the reaction liquid in the detection hole of the reagent strip at the detection position.

[0133] This technical solution simultaneously configures a sample tube supply device 1 with multiple sample tubes, a tip head batch loading device 2 with multiple tip heads 212, and a reagent strip supply device with multiple reagent strips. The positional changes of the sample tubes, tip heads 212, and reagent strips in each step of the point-of-care testing process are achieved by the translation within the parallel plane (XZ plane) of the liquid dispensing device 6 and the reagent strip gripping device 4, and the rotation within the rotational plane (XY plane) of the reaction disk mechanism 5. This greatly simplifies the point-of-care testing process, enables batch online loading of consumables (i.e., tip heads 211), reagents, and samples, and has a high degree of automation to meet the needs of continuous testing and batch loading. It also enables unmanned operation and reduces labor costs.

[0134] See details Figures 2 to 5As shown, in some embodiments, the sample tube supply device 1 includes: a sample rack placement member 11, on which a sample rack slide 111 is constructed for placing a sample rack 12 (on which sample tubes are loaded), and a through groove 112 is constructed on the bottom wall of the sample rack slide 111; a sample rack supply drive assembly for driving the sample rack 12 to slide back and forth along the extension direction of the sample rack slide 111. In this technical solution, the position of the sample rack 12 can be fed by the sample rack supply drive assembly, thereby enabling the position of the liquid-taking head in the corresponding liquid-taking device to be translated and adjusted only in one plane. Thus, the position of the liquid-taking device does not need to be adjusted in the space above the fixed sample rack as in the prior art, the risk of the liquid-taking device impacting the needle is significantly reduced, and the positioning accuracy of the liquid-taking head is improved while the control difficulty is reduced because the liquid-taking head is controlled and adjusted only in one plane.

[0135] In some embodiments, the sample rack supply drive assembly includes: a connecting assembly (not shown in the figure) for selectively connecting to the sample rack 12, i.e., it can be connected to the sample rack 12 or not; and a first sliding drive assembly (not shown in the figure) for driving the connecting assembly to reciprocate along the extension direction of the sample rack slide 111, so that the connecting assembly can drive the sample rack 12 to reciprocate linear displacement toward or away from the liquid collection device under the action of the first sliding drive assembly.

[0136] The sample holder 12 has a claw groove 121 on its bottom outer wall. The connecting assembly includes a first lead screw motor 1311 and a claw 1312 connected to the end of the first lead screw of the first lead screw motor 1311. The first lead screw motor 1311 (specifically a permanent magnet lead screw motor) can drive the claw 1312 to move toward or away from the sample holder 12 so that the claw 1312 is engaged in the claw groove 121 or disengaged from the claw groove 121. Specifically, the claw 1312 moves up and down with the lead screw of the first lead screw motor 1311.

[0137] The first sliding drive assembly includes a first guide rail 1321 and a first rotary motor 1322, which are arranged along the extension direction of the sample rack slide 111. The first rotary motor 1322 can drive the connecting assembly to slide back and forth along the first guide rail 1321. The first guide rail 1321 ensures the stability and reliability of the reciprocating linear motion of the sample rack 12. Specifically, the first rotary motor 1322 can drive the connecting assembly to move through a belt drive structure and a slider component fixedly connected to the belt.

[0138] The sample rack placement component 11 has multiple sample rack slides 111, and the connecting assembly can be controlled to move between the multiple sample rack slides 111 to achieve selective connection of the sample racks 12 placed in different sample rack slides 111, such as... Figure 1 As shown, the sample rack placement component 11 is provided with three sample rack slides 111. In this way, the sample tube supply device can be controlled to drive the sample rack 12 in the next sample rack slide 111 to supply the liquid collection device after the sample tube in the sample rack 12 in one sample rack slide 111 has finished sampling. This achieves the effect of batch online loading without the need for sample tubes to be stopped, which greatly improves the working efficiency of the correlation analyzer and increases the detection throughput.

[0139] At this time, the sample tube supply device further includes a second sliding drive assembly, which can drive the connecting assembly to move between the plurality of sample rack slides 111. The first sliding drive assembly can also drive the connecting assembly and the second sliding drive assembly as a whole to slide back and forth along the extension direction of the sample rack slide 111, improving the degree of automation control of the device. Specifically, the second sliding drive assembly includes a second guide rail 1331 and a second rotary motor 1332 arranged perpendicular to the extension direction of the sample rack slide 111. The second rotary motor 1332 can drive the connecting assembly to slide back and forth along the second guide rail 1331.

[0140] A photoelectric switch 141 is provided at the first position and a through-beam sensor 142 is provided at the second position for each sample rack slide 111. The photoelectric switch 141 and the through-beam sensor 142 are configured in pairs to ensure that the two ends of the sample rack 12 in the length direction can be positioned at the first position and the second position respectively. This ensures that each time the sample rack 12 is manually loaded into the sample tube supply device, the position of the sample rack 12 loaded into the sample rack slide 111 can be placed at the same starting position, thus ensuring precise control of the subsequent supply position of the sample rack 12.

[0141] It should be noted that, in order to accommodate sample tubes of different diameters, a corresponding sample tube adapter 122 can also be provided in the sample hole of the sample holder 12.

[0142] In some embodiments, the liquid collection device 6 includes a liquid collection head 612, the movement of which is limited to a first plane containing the X and Z axes. The target sample tube of the sample holder 12 can be fed along the Y-axis direction to the position below the liquid collection head 612 where the Y-axis intersects the first plane under the action of the sample holder supply drive component. Thus, the position of the liquid collection head 612 is a point location in a two-dimensional plane (XZ plane), and the Y-axis direction is adjusted by the sample holder supply drive component, which simplifies control.

[0143] See details Figures 6 to 8 As shown, the Tip Head Batch Loading Device 2 includes: a consumable assembly, including a tray 211 and a plurality of Tip Heads 212 on the tray 211; a consumable rack, including opposing side plates 221 and a platform 222 on the upper part of the corresponding length end of the two side plates 221, with the opposite side of the two side plates 221 forming a feeding guide rail, and the tray 211 slidably connected to the feeding guide rail; and a feeding drive component, capable of transferring the consumable assembly from a first position to a second position along the feeding track, and capable of transferring the consumable assembly with depleted Tip Heads 212 from the second position to the platform 222, wherein the first position and the second position correspond to the two ends of the length direction of the side plates, respectively. In this technical solution, the feeding guide rail and platform 222 form a double-track system stacked vertically. Consumable components with tip heads 212 are placed on the lower feeding guide rail, while consumable components with exhausted tip heads 212 (i.e., only the tray 211 remains) are placed on the upper platform 222. This reduces the space occupied by the device. The feeding and pushing of consumable components are achieved through the feeding drive component. Users only need to place the consumable component in the first position or remove it from the platform 222, eliminating the need to reach inside, thus improving equipment safety and user convenience. It is worth noting that in this technical solution, the consumable component simultaneously has multiple tip heads 212, and two consumable components can be used in succession, enabling batch online loading of consumables. This avoids downtime loading after the tip heads 212 are exhausted, accelerating the testing speed.

[0144] The consumable component can be moved between the first position and the platform 222 by lifting. However, this lifting method requires a corresponding lifting mechanism, which complicates the equipment structure, increases costs, and makes control cumbersome. In some preferred embodiments, a switching plate 23 is provided between each side plate 221 and the platform 222. The top of the switching plate 23 is pivotally connected to the platform 222, and the bottom of the switching plate 23 contacts the top surface of the side plate 221 under its own weight. The switching plate 23 is inclined to the horizontal plane to facilitate the transfer of the consumable component from the first position to the second position and from the second position to the platform 222. It should be noted that the platform 222 can be constructed in two sections on the two side plates 221. The guide rail section on the opposite side of the tray 211, the top end of the switching plate 23 is connected to the guide rail section, and the bottom end of the switching plate 23 is connected to the feeding guide rail. This allows the switching plate 23 to be lifted upwards (the bottom end of the switching plate 23 rotates and lifts around the top pivot point) when the tray 211 moves from the first position to the second position, facilitating smooth feeding. When the tray 211 moves from the second position to the first position, it is guided by the inclined switching plate 23 into the guide rail section, i.e., placed on the platform 222. This structural design utilizes only the linear reciprocating motion of the feeding drive component to achieve the vertical switching of the tray 211's position, greatly simplifying the device structure and control logic, while reducing the number of components and lowering the device design and manufacturing costs. In some embodiments, the angle of inclination between the switching plate 23 and the horizontal plane is α, 10°≤a≤60°, which ensures smooth vertical switching of the tray 211 while reducing the length of the side plate 221, making the overall device structure more compact.

[0145] In some embodiments, the feeding drive component includes a linear reciprocating drive component and a push-pull assembly, wherein the push-pull assembly applies force to the consumable component, and the linear reciprocating drive component drives the push-pull assembly to generate linear reciprocating motion along the extension direction of the feeding guide rail. In a specific embodiment, the push-pull assembly includes a baffle deflection motor 241, and a baffle 242 is connected to the shaft of the baffle deflection motor 241. The baffle deflection motor 241 can drive the baffle 242 to switch between its initial position and a push-pull position. See [link to specific details]. Figure 1 The baffle 242 shown is in a vertical position, which is the push-pull position. When the baffle 242 is in a horizontal position, it is the initial position. In this technical solution, the connection with the tray 211 is achieved by driving the state change of the baffle 242 through the baffle deflection motor 241, making the push-pull assembly small and compact.

[0146] The baffle 242 has a groove 2421. When the consumable component needs to be transferred from the first position to the second position, the vertical wall of the tray 211 is partially inserted into the groove 2421. At this time, the baffle 242 will apply a pulling force to the tray 211 to ensure reliable and stable connection. When the consumable component needs to be transferred from the second position to the platform 222, the side of the baffle 242 away from the baffle deflection motor 241 abuts against the vertical wall of the tray 211. At this time, the baffle 242 applies a pushing force to the tray 211. Under this condition, the tray 211 does not need to be inserted into the groove 2421, so that it is not necessary to accurately position the baffle 242 and the tray 211, simplifying the control logic.

[0147] In some embodiments, the consumables rack also has a positioning card structure, which can accurately position the tray 211 at the first position. In this way, the relative positional relationship between the baffle 242 and the tray 211 can be ensured by the specific displacement of the baffle 242. For example, after the push-pull assembly moves a first preset distance along the feeding guide, it can contact the vertical wall of the tray 211. At this time, the push-pull assembly is controlled to stop moving forward and the baffle 242 is controlled to be in the initial position. Then, the push-pull assembly is controlled to move forward a second preset distance so that the groove 2421 is aligned with the vertical wall of the tray 211. Then, it stops moving forward and the baffle 242 is controlled to be in the push-pull position. Then, the push-pull assembly is controlled to move forward in the opposite direction a third preset distance to reach the second position, completing one feeding. When all the tips 212 on the tray 211 are used up, the push-pull assembly is controlled to move forward a fourth preset distance in the direction of the first position. Under the guidance of the switching plate 23, the tray 211 is automatically placed on the upper platform, realizing the forward and backward stacking of consumables.

[0148] The linear reciprocating drive component includes a rotary motor 243, and the push-pull assembly also includes a fixed frame 244. The baffle deflection motor 241 is mounted on the fixed frame 244. The rotary motor 243 can drive the displacement of the fixed frame 244 using a gear transmission structure or a lead screw transmission structure. In a preferred embodiment, the rotary motor 243 is driven to the fixed frame 244 via a belt transmission structure. The belt transmission structure has a large length adjustment capability, low manufacturing cost, and is more flexible in terms of the specific component settings. Specifically, the rotary motor 243 is located on the inner side of one of the two side plates 221, and the belt transmission structure is located on the outer side of the side plate 221. The belt transmission structure includes a pulley 245 mounted on the shaft of the rotary motor 243, support rollers 246 spaced apart from the pulley 245 on the linear reciprocating path, and a transmission belt 247 mounted on the pulley 245 and the support rollers 246. The transmission belt 247 is fixedly connected to the fixed frame 244. There are two support rollers 246, which are arranged adjacent to each other vertically, and the sum of the diameters of the two support rollers 246 is equal to the diameter of the pulley 245, so that the conveyor belt 247 is in a horizontal conveying state. In this technical solution, using two support rollers 246 instead of rollers with the same diameter as the pulley 245 can save installation space. At the same time, it can also avoid using a larger diameter shaft to match a larger bearing, which can reduce the load on the drive motor.

[0149] The mounting bracket 244 is equipped with a first sensor 249 (which may be a proximity switch) for detecting the initial position of the baffle 242. The mounting bracket 244 is also equipped with a second sensor (not shown in the figure, which may be a diffuse reflection sensor) for detecting whether the tray 211 is successfully connected to the baffle 242. It is understood that if the connection is successful, the tray 211 will be detected, and if the connection is unsuccessful, the tray 211 will not be detected.

[0150] In some embodiments, a linear guide rail 248 is provided on the outer side of the side plate 221, and the fixing frame 244 is slidably connected to the linear guide rail 248 to ensure the stability of linear reciprocating motion.

[0151] See details Figures 9 to 10As shown, the reagent strip gripping device 4 includes: a mounting member 41; a gripper unit including two gripper arms 421 arranged opposite each other; a gripping device driving component, mounted on the mounting member 41, capable of driving the two gripper arms 421 to move towards or away from each other to form a gripping of the two opposite sidewalls of the reagent strip 90, and capable of driving the gripper unit to rise in a straight line after the gripper arms 421 have gripped the reagent strip 90; and a lateral movement driving component (not shown in the figure, not indexed), capable of simultaneously translating the mounting member 41, the gripper unit, and the gripping device driving component in a horizontal straight line. In this technical solution, the gripper unit can clamp the reagent strip 90 and drive the reagent strip 90 to move linearly in the height direction. At the same time, the lateral movement drive component can drive the reagent strip 90 to move linearly in the horizontal direction. That is, the position of the reagent strip 90 can be adjusted in both the height and horizontal directions, thereby enriching the application scenarios of the reagent strip gripping device. This also facilitates the reasonable layout of the corresponding components of the fully automated chemiluminescence instantaneous detection and analysis instrument in the height and horizontal space, and the structure can be designed to be more compact.

[0152] In some embodiments, the gripper unit further includes a gripper rotating mounting plate 422, which is fixedly connected to the mounting member 41, that is, the relative position between the gripper rotating mounting plate 422 and the mounting member 41 does not change. The two gripper arms 421 are pivotally connected to the gripper rotating mounting plate 422, and one end of each of the two gripper arms 421 is also pivotally connected to a reciprocating slider 423. The reciprocating slider 423 is connected to the power output shaft of the gripping device drive component. When the power output shaft moves close to the gripper arm 421, the two gripper arms 421 move away from each other. When the power output shaft moves away from the gripper arm 421, the two gripper arms 421 move towards each other. In this technical solution, the gripping device driving component drives the reciprocating slider 423 to reciprocate. The reciprocating displacement of the reciprocating slider 423 applies force to the corresponding ends of the two gripper arms 421, thereby enabling the gripper arms 421 to rotate around their pivot connection point with the gripper rotating mounting plate 422. This allows the two gripper arms 421 to move towards or away from each other, thereby clamping or releasing the reagent strip 90. This driving method utilizes the relative position of the reciprocating slider 423 and the gripper rotating mounting plate 422 to achieve the clamping and releasing actions. The structure is simple and compact, and the control logic is simpler, eliminating the need for separate control of the movement of each gripper arm 421.

[0153] To achieve more reliable clamping, a retaining strip 4212 is provided on the opposite side of each of the two gripper arms 421. When the two gripper arms 421 move towards each other, the strip engages with a groove on the corresponding sidewall of the reagent strip 90, effectively preventing the reagent strip 90 from slipping out during clamping. In a preferred embodiment, the retaining strip 4212 has a chamfer on the side facing the reagent strip 90 to guide and correct the position during clamping, ensuring accurate gripping.

[0154] In some embodiments, the reciprocating slider 423 is provided with a horizontally extending groove 4231. The corresponding end of the gripper arm 421 is slidably connected to the groove 4231 via a bearing 4211. Specifically, a bearing pin 4213 is provided at the corresponding end of the gripper arm 421, and the bearings 4211 are respectively fitted at both ends of the bearing pin 4213. Through the bearings 4211, the corresponding end of the gripper arm 421 can slide within the groove 4231 along the length of the groove, ensuring smooth drive of the movement of the gripper arm 421 by the reciprocating slider 423 and preventing jamming during the gripping or contact clamping process.

[0155] As a specific implementation, the gripping device driving component includes a lead screw motor 43 (which is fixedly connected to the mounting component 41 via a corresponding motor mounting base). The power output shaft is the lead screw of the lead screw motor 43. The lead screw motor 43 can directly convert rotary angular displacement into linear displacement of the lead screw. The mounting component 41 is also provided with a guide rail 411, and the reciprocating slider 423 is slidably connected to the guide rail 411, thereby realizing the linear displacement drive of the reciprocating slider 423, simplifying the structure of the reagent strip gripping device, and making the structure more compact. It should also be noted that by using the lead screw motor 43, the self-locking force of the lead screw can be utilized to prevent the reagent strip 90 from falling abnormally during movement and gripping.

[0156] In some embodiments, a first photoelectric sensor 441 is provided near the end of the lead screw away from the gripper unit to detect the position of the lead screw. It is understood that the first photoelectric sensor 441 is fixed to a component that is relatively stationary relative to the mounting base of the lead screw motor 43, such as the mounting member 41. This allows it to be triggered to emit a corresponding position signal when the lead screw moves away from the gripper arm 421 and reaches a preset position, thereby controlling the lead screw motor 43 to stop operating. In other words, the purpose of the first photoelectric sensor 441 is to detect and limit the maximum retraction position of the lead screw.

[0157] The gripper unit also includes a reagent strip pressure application component, which can apply force to the reagent strip 90 when the gripper unit clamps or releases the reagent strip 90. When force is applied to the reagent strip 90 during the clamping process, it can form a reliable clamping of the reagent strip 90 in the height direction with the locking strip 4212 on the gripper arm 421, preventing the position of the reagent strip 90 from changing. During the contact clamping process, it can facilitate the smooth release of the reagent strip 90 from the gripper unit.

[0158] In some embodiments, the reagent strip pressure assembly includes a force-applying column 4241, which is slidably inserted into the gripper rotating mounting plate 422. One end of the force-applying column 4241 facing the reagent strip 90 is a force-applying disk 4242. An elastic element 4243 is sandwiched between the force-applying disk 4242 and the gripper rotating mounting plate 422. In this technical solution, the gripper rotating mounting plate 422 also serves as a displacement guide for the force-applying column 4241, ensuring that the force-applying column 4241 can slide up and down stably and reliably, simplifying the structural design. The elastic element 4243, for example, is a spring fitted around the outer periphery of the force-applying column 4241. Utilizing the elastic compensation effect of the elastic element 4243, force can be applied flexibly to the reagent strip 90, preventing impact damage caused by rigid contact.

[0159] The end of the force-applying column 4241 away from the reagent strip 90 has a U-shaped part 4244. The gripper rotating mounting plate 422 is at least partially located within the opening area of ​​the U-shaped part 4244, which can effectively prevent circumferential displacement that may occur when the force-applying column 4241 is cylindrical. The end of the force-applying column 4241 away from the reagent strip 90 has a detection piece 4245. A second photoelectric sensor 442 is provided corresponding to the detection piece 4245. The second photoelectric sensor 442 is used to detect the position of the force-applying column 4241. When the force-applying column 4241 is in the shape of a cylindrical rod, the second photoelectric sensor 442 detects the position of the force-applying column 4241. When the U-shaped member 4244 is provided at the end of the force-applying column 4241, the detection piece 4245 is provided on the side of the U-shaped member 4244 facing the second photoelectric sensor 442. When the gripper arm 421 clamps the reagent strip 90, the force-applying column 4241 will be pushed upward by a certain displacement. Correspondingly, the detection piece 4245 will also be displaced closer to the side of the second photoelectric sensor 442 and enter the sensing range of the second photoelectric sensor 442, thereby realizing the detection of whether the reagent strip 90 is clamped in place.

[0160] In some embodiments, the reagent strip pressure application assembly has two sets, each set located at one end of the length direction of the gripper rotating mounting plate 422. The two ends of the length direction of the gripper rotating mounting plate 422 correspond to the two ends of the length direction of the reagent strip 90. There are two second photoelectric sensors 442, each corresponding to one end of the length direction of the gripper rotating mounting plate 422. By simultaneously setting the second photoelectric sensors 442 at both ends of the length direction, that is, simultaneously detecting both ends of the length direction of the reagent strip 90, abnormal jamming of the reagent strip 90 when it is released from clamping and placed into the target position (e.g., the corresponding slot) can be effectively monitored (when jamming occurs, the two second photoelectric sensors 442 at both ends will not simultaneously detect the corresponding detection piece 4245).

[0161] See details Figure 17 As shown, in some embodiments, the reagent strip compartment 3 includes multiple independent reagent strip feeding channels 32, and multiple reagent racks 31 are respectively located on each reagent strip feeding channel 32. It also includes a feeding drive device 33. The reagent strip feeding channel 32 can drive the bottom reagent strip of the reagent rack 31 to move linearly toward the reagent strip gripping device 4. The reagent strip gripping device 4 can grip the reagent strip and translate it in the XZ plane to place it on the placement position (idle placement position) of the reaction plate mechanism 5, which can realize the batch online supply of reagent strips.

[0162] See details Figures 11 to 12 As shown, the reaction disk mechanism 5 also includes a mounting base, which includes a top plate 521 and two relatively parallel and spaced side plates 522. The two side plates 522 have first slots 5221 on their opposite side walls, and the top plate 521 is inserted into the first slots 5221. The reaction disk assembly 51 is integrally mounted on the top plate 521. In this technical solution, since the top plate 521 is supported between the two side plates 522 via the first slots 5221, the reaction disk assembly 51 can be assembled with the top plate 521 as a whole before the top plate 521 is installed in the first slots 5221. That is, the assembly and disassembly of the reaction disk assembly 51 do not require top-down or bottom-up installation on the mounting base as in the prior art, greatly reducing the assembly space requirements of the reaction disk mechanism and eliminating the need for additional position correction, thus improving production and maintenance efficiency.

[0163] The mounting base also includes a rear plate 523 connected to one end of the two side plates 522 and a front plate 524 detachably connected to the other end of the side plates 522. The rear plate 523 and the front plate 524 can further position the top plate 521 and prevent the top plate 521 from moving back and forth.

[0164] In some embodiments, the inner wall of the rear upright plate 523 has a second slot (not shown in the figure) corresponding to the first slot 5221, and / or the inner wall of the front upright plate 524 has a third slot (not shown in the figure) corresponding to the first slot 5221, so that the top plate 521 is precisely positioned by the second slot and the third slot.

[0165] The rear upright plate 523 and / or the front upright plate 524 are bolted to the side upright plate 522 by threaded fasteners. After the reaction disk assembly 51 is assembled on the top plate 521 and inserted into the first slot 5221, the front upright plate 524 is connected to the end of the side upright plate 522 by screws, thus completing the assembly and simultaneously positioning the reaction disk assembly 51 without additional correction.

[0166] The reaction disk assembly 51 includes a base 511. A toothed ring 512 is provided on the side of the base 511 facing the top plate 521. A first photoelectric switch 531 is provided on the outer side of the toothed ring 512, capable of sensing the teeth of the toothed ring 512 to determine the rotational angular displacement of the base 511. And / or, a second photoelectric switch 532 is provided on the inner side of the toothed ring 512, capable of sensing a photoelectric baffle located inside the toothed ring 512 to determine the initial rotational position of the base 511. Compared with the prior art's technique of controlling the reaction disk's movement using a single pulse count, the use of the first photoelectric switch 531 and the second photoelectric switch 532 improves the rotational control accuracy of the reaction disk assembly 51. Preferably, the first photoelectric switch 531 and the second photoelectric switch 532 are mounted on the top plate 521, making the structure of the reaction disk mechanism more compact.

[0167] See Figure 12As shown, the reaction disk assembly 51 also includes an incubation plate 513 and a heating plate 514 located between the substrate 511 and the incubation plate 513. The substrate 511 has multiple reagent strip placement positions (not labeled in the figure) extending radially therefrom. The incubation plate 513 has multiple incubation holes 5131. The positions of the incubation holes 5131 correspond one-to-one with the positions of the detection holes of the reagent strips 90 placed on the reagent strip placement positions. It can be understood that each incubation hole 5131 has only one opening facing the detection hole, while the other positions can form a holistic heating effect on the detection hole. Ideally, the incubation holes 5131 and the incubation plate 513 are made of the same material (e.g., aluminum) and are integrally formed, which can ensure the uniform heat transfer of the heating plate 514 and ensure that the temperature of each incubation hole 5131 is consistent, which is beneficial to improving the accuracy of the detection results.

[0168] In some embodiments, the side of the incubation plate 513 facing away from the heating plate 514 is covered with an insulation cover 515, which can reduce the outward radiation of the temperature of the incubation plate 513 and improve the energy utilization rate.

[0169] Understandably, the reaction disk mechanism also includes a reaction disk rotation drive assembly to drive the reaction disk assembly 51 to rotate and switch between different workstations. In one embodiment, the reaction disk rotation drive assembly includes a belt drive component 542, which is disposed on the inner side of the top plate 521. Using the belt drive component 542 allows for more flexible arrangement of related components. Disposing the belt drive component 542 on the inner side of the top plate 521 can improve the safety of the reaction disk mechanism and effectively prevent potential safety accidents to operators.

[0170] The reaction disk assembly 51 includes a rotating shaft assembly 516, which pivotally supports the base 511 and its various components on the top plate 521. The reaction disk rotation drive assembly also includes a rotary motor 541, and the belt drive component 542 can transmit the rotational displacement of the rotary motor 541 to the rotating shaft assembly 516.

[0171] In some embodiments, the top plate 521 is also provided with a reagent strip presence detection component 55 (e.g., a diffuse reflection induction switch), which is located adjacent to the reaction disk assembly 51, so as to determine whether a reagent strip is placed at each reagent strip placement position on the substrate 511, thereby improving the level of intelligent control of the reaction disk mechanism.

[0172] See details Figures 13 to 14As shown, the liquid collection device 6 includes a liquid collection unit, which includes: a liquid collection mounting component 611, which has a sealed cavity; a liquid collection head 612, which is connected to a through hole in the sealed cavity; and a piston rod 613, which is disposed in the sealed cavity and realizes the liquid suction and discharge functions of the liquid collection head 612 under the drive of the reciprocating drive component 62. The telescopic rod of the reciprocating drive component 62 (specifically, for example, the lead screw of a lead screw motor) and the piston rod 613 are connected together by magnetic attraction, so that the piston rod 613 can extend and retract with the extension and retraction of the telescopic rod to realize the liquid suction and discharge of the liquid collection head 612. At the same time, the liquid collection head 612 is directly connected to the sealed cavity without the use of a corresponding hose adapter, avoiding the additional risks caused by hose connection.

[0173] In this technical solution, the piston rod 613 and the telescopic rod are driven and connected by magnetic attraction. This can ensure that the piston rod 613 does not loosen and effectively prevent jamming caused by the misalignment of the piston rod 613 and the telescopic rod axis. The smooth control of the liquid taking process helps to ensure the accuracy of the liquid taking volume.

[0174] In some embodiments, one of the piston rod 613 and the telescopic rod can be made of a magnetic material such as iron, and the other can be equipped with a corresponding magnet. Ideally, the corresponding ends of the two rods are both magnets (preferably permanent magnets) to ensure the reliability of magnetic attraction. Specifically, the end of the telescopic rod facing the piston rod 613 is provided with a first magnet 6141, and the end of the piston rod 613 facing the telescopic rod is provided with a second magnet 6142.

[0175] In another embodiment, an adapter 615 is connected to one end of the telescopic rod facing the piston rod 613. The first magnet 6141 is connected to one end of the telescopic rod through the adapter 615. The adapter 615 can be designed with a corresponding guide structure with the liquid-collecting mounting piece 611 to ensure smooth telescopic movement. Specifically, a guide assembly is provided between the adapter 615 and the liquid-collecting mounting piece 611. The guide assembly includes a pin 6151 fixedly connected to the adapter 615 and a bearing 6152 fitted on the pin 6151. The bearing 6152 can be a deep groove ball bearing. It is understood that the liquid-collecting mounting piece 611 is constructed with a corresponding groove, which can ensure the positioning accuracy of the piston rod 613 and the telescopic rod, and has high sliding smoothness, further preventing the occurrence of sliding jamming.

[0176] Preferably, a limiting structure 616 is provided between the piston rod 613 and the telescopic rod. The limiting structure 616 can be, for example, a limiting plate, one end of which is fixedly connected to the adapter 615, and the other end can form an inwardly bent hook structure to limit the piston rod 613 and prevent the piston rod 613 from detaching due to insufficient magnetic force of the magnet.

[0177] A sealing ring 6131 is fitted on the piston rod 613 to ensure the sealing of the sealing cavity. A sealing ring lock nut 6132 is screwed onto the side of the sealing ring 6131 away from the sealing cavity to ensure the positional reliability of the sealing ring 6131.

[0178] The extension and retraction direction of the piston rod 613 is perpendicular to the flow direction of the liquid collection head 612, which makes the structure of the liquid collection device more reasonable and compact. Correspondingly, the liquid collection device also includes a lifting drive unit, which is driven to the liquid collection unit so as to drive the liquid collection unit to move up and down in the vertical direction.

[0179] The lifting drive unit includes a lead screw motor 631, a slide rail 632, and a slider connector 633. The slider connector 633 and the liquid-collecting mounting part 611 are both slidably connected to the slide rail 632 and can be lifted and lowered along the slide rail 632 under the drive of the lead screw 634 of the lead screw motor 631. The slider connector 633 and the liquid-collecting mounting part 611 are connected by a connecting shaft 635. In this technical solution, the design of the slide rail 632 can ensure the stability of the liquid-collecting unit and the verticality of the liquid-collecting head 612.

[0180] In some embodiments, one end of the connecting shaft 635 is located within the liquid-collecting mounting member 611 and is capable of sliding. A spring 636 is fitted on the connecting shaft 635 to apply force to the liquid-collecting mounting member 611 when the slider connector 633 descends, and to allow the liquid-collecting mounting member 611 to displace toward the slider connector 633 when the liquid-collecting head 612 touches the bottom, thus providing physical protection for the liquid-collecting head 612. The tip head matched with the liquid-collecting head 612 is preferably a disposable conductive tip head, which can prevent cross-contamination and achieve the function of sample liquid level detection. Furthermore, a photoelectric detection component is provided between the slider connector 633 and the liquid-collecting mounting member 611. Even if liquid level leakage (collision pin) occurs, the instrument will detect the collision pin upon bottoming out, thereby replacing the tip head and collecting liquid again, increasing the accuracy of liquid collection.

[0181] The telescopic rod is equipped with a photoelectric baffle 641 at its tail end, and a reset action can be achieved by triggering the photoelectric sensor 642 during movement.

[0182] See details Figures 15 to 16 As shown, the homogeneous chemiluminescence immunoassay module 7 includes: a detection component including a detection head that can be driven to move up and down; and a light-dense component component including a light-dense component 711, on which a light-dense section is constructed. The light-dense component 711 can switch between a first position and a second position. When the light-dense component 711 is in the first position, the light-dense component 711 enables the light-transmitting structure of the detection head to achieve light-dense transmission. When the light-dense component 711 is in the second position, the light-dense structure of the reagent strip corresponding to the detection head enables the light-transmitting structure of the detection head to achieve light-dense transmission. In this technical solution, after the detection module completes the detection operation on the reagent strip and the light-dense structure of the reagent strip separates, the light-dense structure of the light-dense element 711 can continue the light-dense operation, greatly increasing the time the detection head is in a dark light-dense environment. The time the detection head is in contact with the outer ring light environment is only the switching time between the light-dense structure of the reagent strip and the light-dense element 711, that is, the switching time between the first position and the second position. In specific operation, the photomultiplier tube of the detection head can be disconnected from the power supply during this switching time. This reduces the possibility of damage to the photomultiplier tube caused by exposure to external ambient light, and increases the power supply time of the photomultiplier tube, making the signal more stable, effectively reducing the noise of the photomultiplier tube, and improving the accuracy of the detection results.

[0183] In some embodiments, a light-dense adhesive pad 721 is detachably connected to the side of the detection head facing the reagent strip. Since the light-dense adhesive pad 721 will experience wear and tear when switching contact with the light-dense component 711 in this technical solution, it is easy to be damaged. Detachably connecting it to the detection head facilitates replacement. Preferably, the light-dense adhesive pad 721 is snap-fitted to the detection head.

[0184] The detection head is provided with a pressure strip 722 on the side facing the reagent strip. When the light-dense structure of the reagent strip dazzles the light-transmitting structure of the detection head, the pressure strip 722 can press against the top surface of the reagent strip and undergo elastic deformation to prevent the reagent strip below from rising along with the detection head during the process of the detection head being driven upward after the detection is completed. That is, the pressure strip 722 can rely on its own deformation to ensure the separation between the reagent strip and the detection head during the process of the detection head rising.

[0185] Understandably, the detection module also includes a lifting drive assembly for driving the detection head to move linearly reciprocally toward or away from the reagent strip. Specifically, the detection assembly also includes a module fixing component 723, and the lifting drive assembly includes a detection module lead screw motor 724. The lead screw of the detection module lead screw motor 724 can drive the detection head to move up and down, making the overall structure of the module simple and compact.

[0186] Understandably, the detection head is connected to the module fixing part 723 as a whole through the detection head fixing part 731. It is also connected to the laser fixing part 732 for fixing the laser 733 and the photomultiplier tube assembly 734 (including PMT tube and corresponding protective parts). As this is a conventional design structure of homogeneous chemiluminescence immunoassay module, it will not be described in detail here.

[0187] The lead screw motor 724 of the detection module has one end of the lead screw fixedly connected to one end of two parallel linear shafts 726 via a baffle 725. The other ends of the two linear shafts 726 are fixedly connected to the detection head, and the linear shafts 726 are inserted into the guide holes of the module fixing member 723, which can ensure the smooth and reliable lifting and lowering of the detection head. Preferably, an elastic element 727 is fitted on the linear shaft 726 between the baffle 725 and the guide hole to buffer and dampen the vibration during the descent of the detection head. The lead screw motor 724 of the detection module has a photoelectric switch 728 on the side facing the baffle 725, which can detect and determine the retracted position of the baffle 725 (i.e., the highest point of ascent).

[0188] In some embodiments, the homogeneous chemiluminescence immunoassay module further includes a swing drive assembly for driving the light-dense element 711 to switch between the first position and the second position. The swing drive assembly includes a swing drive motor 713, which is configured to control the light-dense element 711 to be in the second position when it is necessary to detect the sample in the detection well on the reagent strip, and to control the light-dense element 711 to be in the first position when it is necessary to switch the reagent strip position after the aforementioned detection is completed.

[0189] The light-diffusing element 711 is provided with supporting rollers 712, which allow the light-diffusing element 711 to slide on a corresponding supporting carrier. This reduces contact friction during the switching process, ensuring smooth position switching. The supporting rollers also reduce the deformation of the light-diffusing element 711. In some embodiments, there are two sets of supporting rollers 712, positioned on opposite sides of the light-diffusing element 711. This opposing arrangement further enhances the smoothness of position switching.

[0190] It should be noted that the technical solution of this invention mainly utilizes the vertical spatial structure and adopts multiple two-dimensional motion superposition methods to achieve three-dimensional motion function; the cooperation between various functional modules realizes the automated operation function of the instrument. Specifically, the drag rod (i.e., the connecting component) in the sample tube supply device 1 can drag the sample holder 12 to move along the Y-axis direction within the sample tube supply device 1, and the liquid retrieval device 6 moves on the X-axis, using the intersection of the X and Y axes to complete the liquid retrieval (sampling) positioning; the tip head box in the tip head batch loading device 2 is grasped by the tip head box gripper (i.e., the baffle 242, the same below) in the tip head batch loading device 2 and moves along the Y-axis direction, and the liquid retrieval device 6 moves on the X-axis, using the intersection of the X and Y axes to complete the positioning of the tip head 212; the reagent strip compartment The motion mechanism composed of an electromagnet and a motor below 3 pushes the reagent below the motion trajectory of the gripper (i.e., the gripper arm 421 of the reagent strip gripping device 4). The gripper only needs to move in the X-axis and Z-axis directions to grip the reagent strip 90. The reaction disk mechanism 5 uses the difference in the radius of the concentric circles to solve the problem of the distance difference between the two parallel X-axis of the liquid dispensing device 6 and the reagent strip gripping device 4. When the incubation channel (i.e., the position of the detection hole) on the reaction disk mechanism 5 rotates to the position below the homogeneous chemiluminescence immunoassay module 7, the homogeneous chemiluminescence immunoassay module 7 can read the number of photons.

[0191] When the reagent strip grabbing device 4 grabs an abnormal reagent strip, the receiving unit 8 moves on the Y-axis and takes over the abnormal reagent strip.

[0192] The analyzer has a control module in its control box 9, which can process the motion timing between various functional modules and receive feedback signals.

[0193] Each functional module enables online batch processing, specifically:

[0194] The sample tube supply device 1 can simultaneously hold three independent sample racks 12, each sample rack 12 has an independent movement channel (i.e., the sample rack slide 111), and the channels do not interfere with each other. Each sample rack can hold 10 samples (specific example, but more or fewer are also possible), so 30 samples can be online at the same time. Since each sample rack 12 is independent, new samples can be loaded into the used or unfilled sample racks without stopping the machine. When the sample rack 12 is placed into the instrument, the instrument automatically moves the sample rack to automatically identify and transmit sample information. The sample tube supply device 1 is designed with a sample tube detection function, which can effectively correct incorrect sample tube placement.

[0195] The Tip Head Batch Loading Device 2 can hold two boxes of Tip Heads, one for use and one for spare, increasing the storage capacity of consumables. Although the Tip Head boxes are all front-to-back, the use of upper and lower channels solves the problem of continuous loading. Through intelligent management of the number of Tip Heads by the system, it can provide advance warning of whether there are enough Tip Heads in the instrument, preventing downtime caused by insufficient consumables.

[0196] The reagent strip compartment 3 is designed with 8 independent channels, each channel can hold one reagent kit (i.e., the reagent rack 31), and each reagent kit can hold 12 test strips, thus allowing for a total of 96 test strips to be loaded at once. Each channel of the reagent strip compartment 3 is independent, so it can be used independently during operation, thereby achieving online loading functionality. The system allows for quantity and item management of each reagent kit 10, avoiding the drawbacks of fixed channels for fixed items.

[0197] The gripper (clamp arm) of the reagent strip gripping device 4 works in conjunction with the reagent strip to ensure the stability of the reagent strip gripping, thereby improving the operating speed of the instrument and reducing the failure rate.

[0198] The reaction plate mechanism 5 serves both as a reagent strip transfer device and an incubation device. The reaction plate mechanism 5 can simultaneously incubate 18 tests; these 18 incubation positions fully meet the instrument's cyclic testing requirements.

[0199] The liquid sampling device 6 uses a disposable sampling tip, eliminating the need for cleaning the sampling needle and reducing the liquid path. The device also incorporates liquid level detection and bottom impact testing, significantly increasing sampling accuracy.

[0200] The homogeneous chemiluminescence immunoassay module 7 adopts a direct-up-down approach, simplifying operation and increasing detection speed. The homogeneous chemiluminescence immunoassay module 7 utilizes a flexible adhesive pad for dense light absorption, resulting in excellent light absorption performance.

[0201] Module 8 can collect abnormal reagent strips to avoid reagent waste.

[0202] It will be readily understood by those skilled in the art that the aforementioned advantageous methods can be freely combined and superimposed without conflict.

[0203] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention. The above are merely preferred embodiments of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present invention, and these improvements and modifications should also be considered within the protection scope of the present invention.

Claims

1. A fully automated homogeneous chemiluminescence real-time detection and analysis instrument, characterized in that, Includes a base (100), on which are provided: A sample tube supply device (1) contains multiple sample tubes; Tip head batch loading device (2), which contains multiple Tip heads (212). The reagent strip supply device includes a reagent strip compartment (3) for storing multiple reagent strips and a reagent strip gripping device (4) capable of gripping and transferring the reagent strips. The reaction disk mechanism (5) includes a reaction disk assembly (51) that can be driven to rotate, having a plurality of reagent strip placement positions extending along its diameter direction; The liquid taking device (6) can be assembled with a Tip head (212) delivered by the Tip head batch loading device (2) and draw the sample from the sample tube delivered by the sample tube supply device (1) and the reagent in the reagent hole of the reagent strip at the reagent strip placement position of the reaction plate assembly (51), and place the sample and / or reagent in the detection hole of the same reagent strip. The homogeneous chemiluminescence immunoassay module (7) is capable of collecting the luminescence information of the reaction solution in the detection well of the reagent strip at the detection position; The tip header bulk loading device (2) includes: Consumable assembly, including a tray (211) and a plurality of said tip heads (212) on said tray (211). The consumables rack includes opposing side plates (221) and a platform (222) located at the upper part of one end of the corresponding length of the two side plates (221). A feeding guide is formed on the opposite side of the two side plates (221), and the tray (211) is slidably connected to the feeding guide. The feeding drive component is capable of transferring the consumable assembly from a first position to a second position along the feeding track, and is capable of transferring the consumable assembly that has exhausted the Tip head (212) from the second position to the platform (222), wherein the first position and the second position correspond to the two ends of the side plate in the length direction, respectively; A switching plate (23) is provided between each of the side plates (221) and the platform (222). The top of the switching plate (23) is pivotally connected to the platform (222), and the bottom of the switching plate (23) is in contact with the top surface of the side plate (221) under its own weight. The switching plate (23) is inclined to the horizontal plane to facilitate the transfer of the consumable component from the first position to the second position and from the second position to the platform (222). The platform (222) consists of two guide rail sections constructed on the opposite sides of the two side plates (221). The top of the switching plate (23) is connected to the guide rail section, and the bottom of the switching plate (23) is connected to the feeding guide rail. Thus, when the tray (211) moves from the first position to the second position, the switching plate (23) can be lifted upward to feed the material smoothly. When the tray (211) moves from the second position to the first position, it enters the guide rail section under the guidance of the inclined switching plate (23), that is, it is placed on the platform (222).

2. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 1, characterized in that, The sample tube supply device (1) includes: The sample rack placement component (11) for placing the sample tube has a sample rack slide (111) for placing the sample rack (12), and a through groove (112) is formed on the bottom wall of the sample rack slide (111). The sample rack supply drive assembly is used to drive the sample rack (12) to slide back and forth along the extension direction of the sample rack slide (111).

3. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 2, characterized in that, The sample rack supply drive component includes: A connecting component for selectively connecting to the sample holder (12); The first sliding drive component is used to drive the connecting component to slide back and forth along the extension direction of the sample rack slide (111); The sample rack placement component (11) has multiple sample rack slides (111), and the connecting component can be controlled to move between multiple sample rack slides (111) to achieve selective connection of the sample racks (12) placed in different sample rack slides (111).

4. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 3, characterized in that, The sample holder (12) has a claw groove (121) on its bottom outer wall. The connecting assembly includes a first lead screw motor (1311) and a claw (1312) connected to the end of the first lead screw of the first lead screw motor (1311). The first lead screw motor (1311) can drive the claw (1312) to move toward or away from the sample holder (12) so that the claw (1312) engages with the claw groove (121) or disengages from the claw groove (121); and / or, The first sliding drive assembly includes a first guide rail (1321) and a first rotary motor (1322) arranged along the extension direction of the sample rack slide (111). The first rotary motor (1322) can drive the connecting assembly to slide back and forth along the first guide rail (1321).

5. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 4, characterized in that, The sample rack placement component (11) has multiple sample rack slides (111), and the connecting component can be controlled to move between multiple sample rack slides (111) to achieve selective connection of the sample racks (12) placed in different sample rack slides (111).

6. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 5, characterized in that, It also includes a second sliding drive component, which is capable of driving the connecting component to move between the plurality of sample rack slides (111), and the first sliding drive component is also capable of driving the connecting component and the second sliding drive component as a whole to slide back and forth along the extension direction of the sample rack slide (111).

7. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 2, characterized in that, A photoelectric switch (141) is provided at the first position and a through-beam sensor (142) is provided at the second position for each of the sample rack slides (111). The photoelectric switch (141) and the through-beam sensor (142) are configured in pairs to ensure that the two ends of the sample rack (12) can be positioned at the first position and the second position respectively; or, The liquid collection device (6) includes a liquid collection head (612), the movement of which is limited to a first plane containing the X-axis and Z-axis. The target sample tube of the sample holder (12) can be fed along the Y-axis direction to the position below the liquid collection head (612) where the Y-axis intersects the first plane under the action of the sample holder supply drive assembly.

8. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 1, characterized in that, The angle of inclination between the switching plate (23) and the horizontal plane is a, 10°≤a≤60°.

9. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 1, characterized in that, The feeding drive component includes: A linear reciprocating drive assembly and a push-pull assembly, wherein the push-pull assembly is used to apply force to the consumable assembly, and the linear reciprocating drive assembly is used to drive the push-pull assembly to generate linear reciprocating motion along the extension direction of the feed guide rail.

10. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 9, characterized in that, The push-pull assembly includes a baffle deflection motor (241), on which a baffle (242) is connected. The baffle deflection motor (241) can drive the baffle (242) to switch between its initial position and the push-pull position.

11. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 10, characterized in that, The baffle (242) has a groove (2421) formed therein. When the consumable component needs to be moved from the first position to the second position, the upright wall of the tray (211) is partially inserted into the groove (2421). When the consumable assembly needs to be transferred from the second position to the platform (222), the side end face of the baffle (242) away from the baffle deflection motor (241) partially abuts against the vertical wall of the tray (211).

12. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 10, characterized in that, The linear reciprocating drive assembly includes a rotary motor (243), and the push-pull assembly also includes a fixed frame (244). The baffle deflection motor (241) is mounted on the fixed frame (244), and the rotary motor (243) is driven to the fixed frame (244) through a belt transmission structure.

13. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 12, characterized in that, The rotary motor (243) is located on the inner side of one of the two side plates (221), and the belt conveyor structure is located on the outer side of the side plate (221). The belt conveyor structure includes a pulley (245) mounted on the shaft of the rotary motor (243), a support roller (246) spaced apart from the pulley (245) on a straight reciprocating path, and a conveyor belt (247) mounted on the pulley (245) and the support roller (246). The conveyor belt (247) is fixedly connected to the fixed frame (244); or, the fixed frame (244) is provided with a first sensor (249) for detecting the initial position of the baffle (242).

14. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 1, characterized in that, The reagent strip gripping device (4) includes: Mounting component (41); The gripper unit includes two gripper arms (421) arranged opposite to each other. The gripping device drive component is mounted on the mounting component (41) and can drive the two gripper arms (421) to move towards or away from each other to form a gripping of the two opposite sidewalls of the reagent strip (90). After the gripper arms (421) grip the reagent strip (90), the gripper unit can be driven to rise in a straight line. The lateral drive component is capable of simultaneously translating the mounting component (41), the gripper unit, and the gripping device drive component along a horizontal straight line.

15. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 14, characterized in that, The gripper unit further includes a gripper rotating mounting plate (422), which is fixedly connected to the mounting member (41). Two gripper arms (421) are pivotally connected to the gripper rotating mounting plate (422), and one end of each gripper arm (421) is also pivotally connected to a reciprocating slider (423). The reciprocating slider (423) is connected to the power output shaft of the gripping device drive component. When the power output shaft moves close to the gripper arm (421), the two gripper arms (421) move away from each other. When the power output shaft moves away from the gripper arm (421), the two gripper arms (421) move towards each other. And / or, a locking strip (4212) is provided on the opposite side of each of the two gripper arms (421).

16. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 15, characterized in that, The reciprocating slider (423) is provided with a horizontally extending groove (4231), and the corresponding end of the gripper arm (421) is slidably connected to the groove (4231) via a bearing (4211); or, The gripping device drive component includes a lead screw motor (43), the power output shaft is the lead screw of the lead screw motor (43), the mounting component (41) is also provided with a guide rail (411), and the reciprocating slider (423) is slidably connected to the guide rail (411).

17. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 16, characterized in that, A first photoelectric sensor (441) is provided near the end of the lead screw away from the gripper unit to detect the position of the lead screw.

18. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 15, characterized in that, The gripper unit also includes a reagent strip pressure application component, which can apply force to the reagent strip (90) when the gripper unit clamps or releases the reagent strip (90).

19. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 18, characterized in that, The reagent strip pressure assembly includes a force-applying column (4241), which is slidably inserted into the gripper rotating mounting plate (422). One end of the force-applying column (4241) facing the reagent strip (90) is a force-applying disc (4242), and an elastic element (4243) is clamped between the force-applying disc (4242) and the gripper rotating mounting plate (422).

20. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 19, characterized in that, The force-applying column (4241) has a U-shaped part (4244) at one end away from the reagent strip (90), and the gripper rotating mounting plate (422) is at least partially located within the opening area of ​​the U-shaped part (4244); and / or, the force-applying column (4241) has a detection piece (4245) at one end away from the reagent strip (90), and a second photoelectric sensor (442) is provided corresponding to the detection piece (4245), the second photoelectric sensor (442) being used to detect the position of the force-applying column (4241).

21. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 20, characterized in that, The reagent strip pressure application assembly has two sets, and the two sets of reagent strip pressure application assemblies are respectively located at both ends of the length direction of the gripper rotating mounting plate (422). The two ends of the length direction of the gripper rotating mounting plate (422) correspond to the two ends of the length direction of the reagent strip (90). There are two second photoelectric sensors (442), and the two second photoelectric sensors (442) are respectively set at both ends of the length direction of the gripper rotating mounting plate (422).

22. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 1, characterized in that, The reaction disk mechanism (5) also includes: The mounting base includes a top plate (521) and two relatively parallel and spaced side plates (522). The two side plates (522) have a first slot (5221) on their opposite side walls, and the top plate (521) is inserted into the first slot (5221). The reaction disk assembly (51) is installed on the top plate (521).

23. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 22, characterized in that, The mounting base also includes a rear plate (523) connected to one end of the two side plates (522) and a front plate (524) detachably connected to the other end of the side plates (522).

24. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 23, characterized in that, The inner wall of the rear upright plate (523) has a second slot corresponding to the first slot (5221), and / or the inner wall of the front upright plate (524) has a third slot corresponding to the first slot (5221); or the rear upright plate (523) and / or the front upright plate (524) are bolted to the side upright plate (522) by threaded parts.

25. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 22, characterized in that, The reaction disk assembly (51) includes a base (511), and a toothed ring (512) is provided on the side of the base (511) facing the top plate (521). A first photoelectric switch (531) is provided on the outer side of the toothed ring (512), and the first photoelectric switch (531) can sense the teeth of the toothed ring (512) to determine the rotational angular displacement of the base (511); and / or, a second photoelectric switch (532) is provided on the inner side of the toothed ring (512), and the second photoelectric switch (532) can sense the photoelectric baffle located on the inner side of the toothed ring (512) to determine the initial rotational position of the base (511).

26. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 25, characterized in that, The reaction disk assembly (51) also includes an incubation plate (513) and a heating plate (514) located between the substrate (511) and the incubation plate (513). The substrate (511) has a plurality of reagent strip placement positions extending radially therefrom. The incubation plate (513) has a plurality of incubation holes (5131). The positions of the incubation holes (5131) correspond one-to-one with the positions of the detection holes of the reagent strips (90) placed on the reagent strip placement positions. The incubation holes (5131) are made of the same material as the incubation plate (513) and are integrally formed.

27. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 1, characterized in that, The liquid collection device (6) includes a liquid collection unit, which includes: Liquid extraction mounting component (611) has a sealed cavity inside; A liquid-collecting head (612) is connected to a through hole in the sealed cavity and can be assembled with the tip head (212); The piston rod (613) is disposed in the sealed cavity and, driven by the reciprocating drive component (62), realizes the liquid suction and discharge functions of the liquid taking head (612); The telescopic rod of the reciprocating drive component (62) and the piston rod (613) are connected together by magnetic attraction.

28. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 27, characterized in that, The telescopic rod is provided with a first magnet (6141) at one end facing the piston rod (613), and a second magnet (6142) is provided at one end facing the telescopic rod; and / or, the telescopic rod is a motor lead screw.

29. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 28, characterized in that, The telescopic rod is connected to an adapter (615) at one end facing the piston rod (613), and the first magnet (6141) is connected to one end of the telescopic rod through the adapter (615).

30. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 29, characterized in that, A guide assembly is provided between the adapter (615) and the liquid extraction mounting component (611). The guide assembly includes a pin (6151) fixedly connected to the adapter (615) and a bearing (6152) fitted on the pin (6151).

31. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 30, characterized in that, A limiting structure (616) is also provided between the piston rod (613) and the telescopic rod.

32. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 27, characterized in that, The extension and retraction direction of the piston rod (613) is perpendicular to the flow direction of the liquid taking head (612); and / or, it also includes a lifting drive unit, which is drivenly connected to the liquid taking unit.

33. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 32, characterized in that, The lifting drive unit includes a lead screw motor (631), a slide rail (632), and a slider connector (633). The slider connector (633) and the liquid collection mounting component (611) are both slidably connected to the slide rail (632) and can be lifted and lowered along the slide rail (632) under the drive of the lead screw (634) of the lead screw motor (631). The slider connector (633) and the liquid collection mounting component (611) are connected by a connecting shaft (635).

34. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 33, characterized in that, One end of the connecting shaft (635) is located inside the liquid-collecting mounting (611) and can slide. A spring (636) is fitted on the connecting shaft (635) to apply force to the liquid-collecting mounting (611) when the slider connector (633) descends, and to allow the liquid-collecting mounting (611) to move toward the slider connector (633) when the liquid-collecting head (612) touches the bottom.

35. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 1, characterized in that, The homogeneous chemiluminescence immunoassay module (7) includes: The detection assembly includes a detection head that can be driven to rise and fall. The light-dense component assembly includes a light-dense component (711) which is switchable between a first position and a second position. When the light-dense component (711) is in the first position, it enables the light-transmitting structure of the detection head to achieve light-dense operation. When the light-dense component (711) is in the second position, the light-dense structure of the reagent strip corresponding to the detection head enables the light-transmitting structure of the detection head to achieve light-dense operation.

36. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 35, characterized in that, The detection head is detachably connected to a light-dense adhesive pad (721) on the side facing the reagent strip; and / or, The detection head is provided with a pressure strip (722) on the side facing the reagent strip. When the light-dense structure of the reagent strip dazzles the light-transmitting structure of the detection head, the pressure strip (722) can press against the top surface of the reagent strip and undergo elastic deformation.

37. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 35, characterized in that, It also includes a lifting drive assembly for driving the detection head to reciprocate linearly toward or away from the reagent strip; And / or, It also includes a swing drive assembly for driving the light-diffusing element (711) to switch between the first position and the second position.

38. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 37, characterized in that, The light-diffusing component (711) is provided with a support roller (712), and the light-diffusing component (711) can slide on the corresponding support carrier via the support roller (712).

39. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 38, characterized in that, The support rollers (712) are in two sets, and the two sets of support rollers (712) are disposed on opposite sides of the light-diffusing element (711).

40. The fully automated homogeneous chemiluminescence real-time detection and analysis instrument according to claim 1, characterized in that, Also includes: The receiving unit (8) is used to receive abnormal reagent strips grasped by the reagent strip grasping device (4).

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