Tissue retainer assembly and its components

Abstract

A tissue retainer cap for covering a tissue retainer includes a cover having a periphery, an outer surface, and an inner surface opposite the outer surface. The cover includes: a central portion having an opening configured to receive a central post of the tissue retainer; a first latch extending from the periphery of the cover; and a second latch extending from the periphery of the cover and circumferentially spaced from the first latch. The cover also includes a first protrusion configured to engage the post of the tissue retainer. When the first protrusion engages the post, each of the first and second latches automatically aligns with one or more of a plurality of tabs located on a circumferential sidewall of the tissue retainer, thereby securely fastening the tissue retainer cap to the tissue retainer.

Description

[0001] Relevant application data

[0002] This application claims the benefit of priority to U.S. Provisional Patent Application No. 62 / 941,194, filed November 27, 2019, pursuant to 35 USC §119. Technical Field

[0003] This disclosure generally relates to apparatus and methods for disposing of biopsy tissue samples for imaging and for storing such biopsy tissue samples. Background Technology

[0004] A biopsy is a well-known medical procedure involving the removal and examination of tissue from a living body for diagnostic research, such as determining the presence, cause, or extent of a disease. For example, a biopsy of human breast tissue can be performed to diagnose breast cancer or other diseases. Generally, biopsies can be performed via open surgery or percutaneous methods. An open surgical biopsy procedure involves making an open incision at the site of tissue of interest, cutting a sample of tissue, and removing the tissue through the open incision. A percutaneous biopsy is performed by inserting a biopsy device with a needle and cutting mechanism through a small incision and advancing the needle and cutting mechanism to the site of tissue of interest. The cutting mechanism then cuts the tissue sample, and the biopsy device captures the tissue sample and removes it through the small incision. Percutaneous biopsy devices have been used in various ways to remove tissue samples, such as simply removing the device along with the captured tissue sample through an incision, or transporting the tissue sample through the device (e.g., using vacuum extraction), where the tissue sample can be removed through a tube or aspirated into a container. One advantage of removing tissue samples from a biopsy device is that multiple samples can be obtained without removing the biopsy device.

[0005] Then, the tissue sample is imaged using X-rays, MRI (magnetic resonance imaging), or other suitable imaging devices to examine the tissue sample for diagnosis (although previous X-ray imaging systems recorded on membranes, more recent X-ray imaging systems are digital and use semiconductor receptors for recording). For example, the tissue sample can be placed on an imaging substrate (such as a tissue slide or membrane) and then placed in an imaging device to take an image.

[0006] Automated biopsy and imaging systems for performing biopsies and imaging tissue samples are also disclosed. For example, U.S. Patent No. 9,492,130 B2 discloses an integrated biopsy analysis system having a biopsy excision tool, a tissue sample transport mechanism for automatically transporting the excised tissue sample from the biopsy excision tool to an analysis / imaging unit, and an analysis / imaging system for automatically analyzing the tissue sample (e.g., imaging using an X-ray imaging device). The entire contents of U.S. Patent No. 9,492,130 B2 are incorporated herein by reference. The disclosed system excises a tissue sample and transfers and places the excised tissue sample into a sample holder having multiple tissue receiving slots for placing multiple different tissue samples. The imaging unit is configured to acquire images of the tissue sample in the tissue holder, for example by acquiring a separate image of each tissue sample in its respective tissue receiving slot.

[0007] In some cases, it may be desirable to store tissue samples after imaging is complete. For example, after imaging is performed, it may be desirable to transfer tissue samples to a pathology laboratory for further analysis and storage. Thus, efficient and effective devices and methods for transporting tissue samples are also desired, holding each sample in its corresponding tissue receiving slot within a tissue holder. Summary of the Invention

[0008] A tissue retainer cap for covering a tissue retainer having a bottom, circumferential sidewalls extending upward from the bottom, a hub, a post extending upward from the hub, and a plurality of partition walls extending radially outward from the hub to define a plurality of tissue storage compartments. The tissue retainer cap includes: a cover having a periphery, an outer surface, and an inner surface opposite the outer surface; wherein a central portion of the cover includes an opening configured to receive the post of the tissue retainer; a first latch extending from the periphery of the cover; and a second latch extending from the periphery of the cover and circumferentially spaced from the first latch; wherein the cover includes a first protrusion configured to engage the post of the tissue retainer, and wherein when the first protrusion engages the post, each of the first latch and the second latch automatically aligns with one or more of a plurality of tabs located on the circumferential sidewall of the tissue retainer, thereby securely fastening the tissue retainer cap to the tissue retainer.

[0009] Optionally, the tissue retainer includes an edge, wherein the cover of the tissue retainer includes a sealing portion extending circumferentially around the cover, the sealing portion having a bottom surface for abutting against the edge of the tissue retainer, and wherein the inner surface of the cover is recessed relative to the bottom surface of the sealing portion.

[0010] Optionally, the post of the tissue retainer includes a first recess, and the first protrusion of the tissue retainer cap is configured to be placed within the first recess when the protrusion engages with the post.

[0011] Optionally, the cover includes a second protrusion, wherein the post of the tissue retainer includes a first recess and a second recess, and wherein the first protrusion and the second protrusion are configured to engage with the first recess and the second recess of the post of the tissue retainer, respectively.

[0012] Optionally, the first protrusion and the second protrusion are on opposite sides of the opening in the cover.

[0013] Optionally, the first latch is radially aligned with the first protrusion and / or can be elastically moved relative to the cover.

[0014] Optionally, the tissue retainer cap further includes a first finger-like protrusion extending from the first latch, wherein the first finger-like protrusion is configured to move the first latch to separate the tissue retainer cap relative to the tissue retainer.

[0015] Optionally, the tissue retainer cap further includes a stop configured to prevent excessive flexure of the first finger-like protrusion.

[0016] Optionally, the first latch is configured to abut against the bottom of the tissue retainer for anchoring.

[0017] Optionally, the first latch is configured to abut against one of the tabs for anchoring, and wherein the first latch includes a latch opening configured to receive one of the tabs.

[0018] Optionally, the first latch includes a first anchor and a second anchor, the first anchor and the second anchor being configured to simultaneously abut and anchor adjacent tabs among the plurality of tabs.

[0019] Optionally, the cover includes a plurality of vent holes located between the periphery of the cover and the opening of the cover.

[0020] Optionally, at least one of the vents has a cross-sectional dimension of less than or equal to 0.03 inches.

[0021] Optionally, at least one of the vent holes has a cross-sectional dimension that increases along the thickness of the cover.

[0022] Optionally, the number of vents increases as a function of the distance from the opening.

[0023] A tissue storage system includes the tissue retainer cap and the tissue retainer.

[0024] Optionally, the post of the tissue retainer includes a first recess, and each pair of adjacent tabs of the tissue retainer defines a space between the adjacent tabs, and the space or one of the tabs is radially aligned with the first recess of the post of the tissue retainer.

[0025] A tissue retainer includes: a bottom having a filter; a circumferential sidewall extending upward from the bottom; a hub having a cavity; a plurality of partition walls extending from the hub to define a plurality of tissue storage compartments; a column extending upward from the hub; and a channel extending from the cavity of the hub into the column, wherein the channel is off-center relative to the column.

[0026] A tissue storage system includes the tissue retainer and the tissue retainer cap, the tissue retainer cap being configured to be securely fastened to the tissue retainer.

[0027] Optionally, the tissue retainer cap includes: a cover having an opening at its periphery and at its center, wherein the cover has an outer surface and an inner surface opposite to the outer surface; a first latch; and a second latch, wherein the second latch is circumferentially spaced from the first latch.

[0028] Optionally, the first latch is configured to anchor against a first tab at the circumferential sidewall of the tissue retainer, and the second latch is configured to anchor against a second tab at the circumferential sidewall of the tissue retainer.

[0029] Optionally, the first latch is configured to anchor a first pair of tabs against the circumferential sidewall of the tissue retainer, and the second latch is configured to anchor a second pair of tabs against the circumferential sidewall of the tissue retainer.

[0030] Optionally, the first latch is configured to abut against the bottom of the tissue retainer for anchoring.

[0031] A method of disposing of a tissue sample includes: receiving the tissue sample by a tissue retainer having a plurality of tissue storage compartments, a hub, and a post extending from the hub, wherein receiving the tissue sample is performed while the tissue retainer is movably located within a tissue retainer assembly; receiving a first protrusion of a tissue retainer cap by a recess at the post of the tissue retainer to align a first latch of the tissue retainer cap with a first portion of the tissue retainer and align a second latch of the tissue retainer cap with a second portion of the tissue retainer; and securely attaching the tissue retainer cap to the tissue retainer to retain the tissue sample within the tissue storage compartment of the tissue retainer, wherein secure attachment is performed by the first and second latches of the tissue retainer cap abutting against the tissue retainer for anchoring.

[0032] Optionally, the first portion of the tissue retainer includes a first tab at the circumferential sidewall of the tissue retainer, and the second portion of the tissue retainer includes a second tab at the circumferential sidewall of the tissue retainer.

[0033] Optionally, the first portion of the tissue retainer includes a first pair of tabs at the circumferential sidewall of the tissue retainer, and the second portion of the tissue retainer includes a second pair of tabs at the circumferential sidewall of the tissue retainer.

[0034] Optionally, the first portion of the tissue retainer includes a first bottom of the tissue retainer, and the second portion of the tissue retainer includes a second bottom of the tissue retainer.

[0035] Other and further aspects and features will become clear by interpreting the following detailed implementation methods. Attached Figure Description

[0036] The accompanying drawings illustrate the design and practicality of the embodiments, wherein similar elements are indicated by common reference numerals. These drawings are not necessarily drawn to scale. To better understand how the above and other advantages and objectives are achieved, a more specific description of the embodiments, shown in the accompanying drawings, will be presented. These drawings depict exemplary embodiments only and should therefore not be considered as limiting the scope of the claims.

[0037] Figure 1 A tissue retainer assembly having a base, a tissue retainer assembly cover, and a tissue retainer is shown;

[0038] Figure 2 The assembly is shown. Figure 1 Tissue retainer components;

[0039] Figure 3 yes Figure 1 and Figure 2 A top view of the tissue retainer component;

[0040] Figure 4 It includes Figure 1 A schematic diagram of a biopsy system with a tissue retainer assembly;

[0041] Figure 5 The following diagrams are shown for use and / or operation. Figure 1 A flowchart of the method for the tissue retainer component;

[0042] Figures 6A to 6B A tissue retainer cap for covering a tissue retainer is shown according to some embodiments;

[0043] Figures 7A to 7B Another tissue retainer cap for covering a tissue retainer, according to other embodiments, is shown;

[0044] Figures 8A to 8F Another tissue retainer cap for covering a tissue retainer, according to other embodiments, is shown;

[0045] Figures 9A to 9C Another tissue retainer cap for covering a tissue retainer, according to other embodiments, is shown;

[0046] Figure 10 Another tissue retainer cap for covering a tissue retainer, according to other embodiments, is shown;

[0047] Figure 11 Another tissue retainer cap for covering a tissue retainer, according to other embodiments, is shown;

[0048] Figure 12A A bottom perspective view of the tissue retainer is shown; and

[0049] Figure 12B A top perspective view of the tissue retainer is shown. Detailed Implementation

[0050] Various embodiments are described below with reference to the accompanying drawings. It should be noted that the drawings are not drawn to scale, and elements with similar structures or functions are indicated by the same reference numerals throughout the drawings. It should also be noted that the drawings are intended only to facilitate the description of the embodiments. These drawings are not intended as an exhaustive description of the invention or as a limitation on the scope of the invention. Furthermore, the illustrated embodiments do not need to have all the aspects or advantages shown. Aspects or advantages described in connection with a particular embodiment are not necessarily limited to that embodiment and can be practiced in any other embodiment, even if not so shown or so explicitly described.

[0051] Figures 1 to 3 An embodiment of a tissue retainer assembly 10 for receiving multiple tissue samples is shown. The tissue retainer assembly 10 includes a housing 12 having a base 14 and a cover 16 removably attached to the base 14. The base 14 and the attached cover 16 form an interior or chamber in which a tissue retainer 18 is enclosed. The base 14 has a spindle 36 having a hub 38 for receiving the tissue retainer 18, such that the tissue retainer 18 can rotate relative to the housing 12 about an axis 20. In other words, the base 14 and the cover 16 remain stationary, and the tissue retainer 18 rotates within the chamber formed by the base 14 and the cover 16. The tissue retainer 18 can be rotated using any suitable actuator and may include a magnet detected by a Hall effect sensor to identify when the tissue filter is in its original position.

[0052] The base 14 has a bottom member 43 and a cylindrical sidewall 41 extending upward from the bottom member 43. The bottom member 43 may include a substantially flat plate. The bottom member 43 has a plurality of retaining clips 45a, 45b that are removably attached to the tissue biopsy system 50 (see [link]). Figure 1 A retainer fitted onto the chassis, frame, housing, etc. A spindle 36 is attached to and extends upward from the bottom member 43. The tissue retainer 18 has a bottom 21 and circumferential sidewalls 25 extending upward from the bottom 21. Figure 3 As shown, the tissue retainer 18 also has a plurality of tissue storage compartments 22 arranged at an angle around the tissue retainer 18 (in this case, the tissue retainer 18 has thirteen tissue storage compartments 22, but any number of compartments 22 can be used). The tissue storage compartments 22 are defined by radially extending partition walls 23 extending radially from the hub 38 to the sidewalls 25. The tissue storage compartments 22 (also referred to as tissue containers 22) are separated and partially formed by the radially extending compartment walls 23. In this exemplary embodiment, the tissue retainer 18 has a circular shape such that the tissue storage compartments 22 are wedge-shaped (i.e., disc-shaped, circular sector-shaped), or an annular sector-shaped if the central portion of each tissue storage compartment 22 does not extend all the way to the axis 20. The tissue container 22 is connected to the hub 38 of the tissue retainer 18, which is centrally located at the axis 20. The hub 38 is circular and has an opening that allows the mandrel 36 of the base 14 to be fitted through the opening.

[0053] The bottom 21 of the tissue holder 18 includes a tissue filter 24 with a porous filter material. The tissue filter 24 may be a single filter, such as a filter sheet, covering the entire bottom of the tissue holder 18. Alternatively, the tissue filter 24 may be multiple individual filters arranged on the bottom of each tissue storage compartment 22. A fluid removal mechanism 28 is arranged within the interior formed by the base 14 and the cover 16. The fluid removal mechanism 28 is configured to remove fluid from the filters 24 located below the bottom of the multiple tissue storage compartments 22 to improve the quality of images acquired from tissue samples in the tissue storage compartments. The fluid removal mechanism 28 may be attached to the bottom member 43 and located below the tissue holder 18.

[0054] The fluid removal mechanism 28 can be any device configured to remove fluid from the bottom of the tissue retainer 18. In some embodiments, the fluid removal mechanism 28 can be a fluid reservoir configured to remove fluid from the bottom surface of the filter 24. In other embodiments, the fluid removal mechanism 28 can be a gas nozzle pointing towards the bottom surface of the filter 24. The gas nozzle can be configured to direct gas (e.g., air) through the tissue storage compartment 22. The airflow removes fluid adhering to the bottom surface of the filter 24. In yet another embodiment, the fluid removal mechanism 28 can be a suction device. In still another embodiment, the tissue retainer assembly 10 may not include the fluid removal mechanism 28.

[0055] The base 14 has a spindle 36. The spindle 36 of the base 14 rotatably receives the hub 38 of the tissue holder 18, such that the tissue holder 18 can rotate relative to the base 14.

[0056] Tissue retainer assembly 10 has a tissue sample inlet port 42 (also referred to as inlet port 42) on cover 16, to which inlet tube 46 is connected (see Figure 1 The other end of the inlet tube 46 is connected to the biopsy excision tool 60 (see...). Figure 1 This allows tissue samples removed by the biopsy excision tool 60 to be transported through the inlet tube 46 from the biopsy excision tool 60 into the tissue holder assembly 10 and into one of the tissue storage compartments 22. The tissue holder assembly 10 has an outlet port 44 (also referred to as a vacuum port 44) on the base 14 to which an aspiration tube 48 is connected. The outlet port 44 extends from the outside to the inside of the housing 12, for example, through the sidewall 41. The other end of the aspiration tube 48 is connected to an aspiration canister 62 or another suitable vacuum source. The vacuum port 44 draws liquids and / or other materials from the base and also provides a vacuum within the cavity formed by the housing 12 to draw tissue samples through the inlet port 42 for storage in the corresponding tissue storage compartment 22 of the tissue holder 18.

[0057] refer to Figure 4 A schematic diagram of the tissue biopsy system 50 is shown. Although Figure 4 The schematic diagram only shows certain features of the biopsy system 50, but the biopsy system 50 can be a biopsy system as disclosed in U.S. Patent No. 9,492,130 B2 cited above, and can include any features disclosed therein. The biopsy system 50 includes a tissue retainer assembly 10 attached to a biopsy excision tool 60 and an aspiration canister 62. The biopsy system 50 also includes an imaging unit 64 configured to capture images of tissue samples contained in each of the tissue storage compartments 22. The imaging unit 64 has an imaging device 66 (e.g., an X-ray imaging device 66) or other suitable imaging device for capturing images. The imaging device 66 has an imaging field in which it can acquire images of material positioned within the imaging field.

[0058] refer to Figure 5 The method 100 for using and operating the tissue retainer assembly 10 will now be described. At item 102, the tissue retainer assembly 10 is installed into an automated biopsy system 50 (e.g., the system described in U.S. Patent No. 9,492,130 B2 above), wherein the biopsy excision tool 60 is connected to the inlet tube 46 and a vacuum source is connected to the aspiration tube 48. The tissue retainer assembly 10 or only the tissue retainer 18 (e.g., the tissue retainer 18 can be installed into a tissue retainer assembly installed in system 50) can be manually installed into the automated biopsy system 50, or system 50 can include a robot configured to automatically install the tissue retainer assembly 10 or only the tissue retainer 18 into system 50.

[0059] At item 104, the tissue holder 18 is rotated to position the first tissue storage compartment 22 at the loading position of the tissue filter holder 18, such that tissue samples transported through the inlet port 42 are stored in the first tissue storage compartment 22 of the tissue holder 18.

[0060] At item 106, the first tissue sample is removed using the biopsy excision tool 62, and the first tissue sample is transported through the inlet tube 46 and the inlet port 42 and stored in the first tissue storage compartment 22 of the tissue holder 18.

[0061] At item 108, the tissue retainer 18 is rotated such that the bottom surface of the filter 24 below the first tissue storage compartment 22 moves past the fluid removal mechanism 28 (where the bottom surface of the filter 24 contacts the fluid removal mechanism 28), thereby removing fluid residues accumulated on the bottom surface of the filter 24 below the first tissue storage compartment 22.

[0062] At item 110, the first tissue storage compartment 22 is positioned in the imaging field of the imaging unit 64 to obtain an image of the first tissue sample in the first tissue storage compartment 22. The imaging field can be positioned so that it passes just past the fluid removal mechanism 28 in the direction of movement of the first tissue storage compartment 22 in item 108, such that the first tissue storage compartment 22 is positioned in the imaging field by the movement of the tissue holder 18 in item 108.

[0063] At item 112, an image of the first tissue sample is acquired using imaging unit 64.

[0064] At item 114, the tissue holder 18 is rotated to position the second tissue storage compartment 22 in the loading position of the tissue holder 18, such that tissue samples transported through the inlet port 42 can be stored in the second tissue storage compartment 22. This positioning can occur during the same movement as items 108 and / or 110. In other words, the second tissue storage compartment 22 can be positioned in the loading position as the first tissue storage compartment 22 moves past the fluid removal mechanism 28.

[0065] At item 116, a second tissue sample is removed using a biopsy excision tool 60, and the second tissue sample is transported through an inlet tube 46 and an inlet port 42 and stored in the second tissue storage compartment 22 of the tissue holder 18.

[0066] At item 118, the tissue retainer 18 is rotated such that the bottom surface of the filter 24 below the second tissue storage compartment 22 moves past the fluid removal mechanism 28 (where the bottom surface of the filter 24 contacts the fluid removal mechanism 28), thereby removing fluid residues accumulated on the bottom surface of the filter 24 in the second tissue storage compartment 22.

[0067] At item 120, the second tissue storage compartment 22 is positioned in the imaging field of the imaging unit 64 to obtain an image of the second tissue sample in the second tissue storage compartment 22. Similarly, the imaging field can be positioned so that it passes just past the fluid removal mechanism 28 in the direction of movement of the second container 22 in item 118, such that the second tissue storage compartment 22 is positioned in the imaging field by the movement of the tissue holder 18 in item 118.

[0068] At item 122, an image of the second tissue sample is acquired using imaging unit 64. This process is repeated until all desired tissue samples have been acquired, stored in tissue storage compartment 22, and images have been acquired for all corresponding tissue samples in each of tissue storage compartment 22.

[0069] Alternatively, images of the tissue samples in the tissue storage compartments 22 can be acquired after all samples have been acquired. First, all tissue samples are acquired and stored in their respective tissue storage compartments 22 by rotating each tissue storage compartment 22 to the loading position, removing the tissue sample, and storing the tissue sample in its corresponding tissue storage compartment 22. Then, the tissue holder 18 is rotated to remove fluid from each of the tissue containers 22 in the tissue holder 18, and the tissue samples in the tissue holder assembly 10 are imaged. All tissue samples can be imaged at once by taking a single image of all the tissue containers 22 in the tissue holder 18, processing the images to identify individual containers 22, and separating each image from each container 22. Alternatively, the tissue holder 18 can be rotated to take individual images of each container until images of all the corresponding tissue samples in each of the tissue containers 22 have been taken. In yet another embodiment, the tissue holder assembly 10 is placed in an imaging unit (e.g., an X-ray imaging apparatus). In a manual system, the filter assembly 10 can be manually installed in the imaging unit 54.

[0070] In automated and integrated systems (such as those described above), the tissue holder assembly 10 is already positioned in the imaging unit 64 during the biopsy resection, or a robot can place the tissue holder assembly 10 in the imaging unit 64. The tissue holder 18 is then rotated to move the tissue storage compartment 22 past the fluid removal mechanism 28, positioning the tissue storage compartment 22 in the imaging position, and an image is acquired using the imaging unit 64. This process is repeated for each of the tissue storage compartments 22 containing the tissue sample to be imaged.

[0071] Once the biopsy has been completed, the tissue sample is transported to a pathology laboratory for further analysis. This is achieved by removing the tissue retainer assembly 10 from system 50 and removing the cover 16 of the tissue retainer assembly 10 to gain access to the tissue retainer 18. The tissue retainer 18 can then be removed from the tissue retainer assembly 10 and placed in a formalin-filled sample container for transport. In some embodiments, the tissue retainer 18 can be sealed or covered with a tissue retainer cap to hold the tissue sample within the tissue storage compartment 22 and restrict movement or migration of the tissue sample between adjacent tissue storage compartments 22 during transport.

[0072] Figures 6A to 6B A tissue retainer cap 200 for covering a tissue retainer 18 is shown according to some embodiments. (See figures) Figure 1 and Figure 3As shown, the tissue retainer 18 has a bottom 21 with a filter 24, circumferential sidewalls 25 extending upward from the bottom 21, a hub 38, posts 230 extending upward from the hub 38, and a plurality of partition walls 23 extending from the hub 38 to define a plurality of tissue storage compartments 22. In the illustrated embodiment, a tissue retainer cap 200 is removably attached to the tissue retainer 18, for example by attaching to the sidewalls 25 of the tissue retainer 18. The tissue retainer cap 200 is configured to correspond to the shape of the tissue retainer 18 to seal the tissue retainer 18. For example, in an exemplary embodiment, the tissue retainer cap 200 includes a cover 202 (different from the cover 16 described above) having an outer sealing portion 203 and a central portion defining an opening 204 to receive the posts 230 of the tissue retainer 18. When the tissue retainer cap 200 is attached to the tissue retainer 18 and the tissue retainer 18 is transported to a pathology laboratory, the cover 202 closes the tissue storage compartment 22 to retain the tissue sample within the tissue storage compartment 22. The cover 202 has an outer surface 203a and an inner surface 203b opposite to the outer surface 203a. The tissue retainer cap 200 also includes a first latch 220 and a second latch 220 circumferentially spaced apart from each other. In an exemplary embodiment, the first latch 220 and the second latch 220 are radially aligned with each other. In other embodiments, the first latch 220 and the second latch 220 may not be radially aligned with each other. Furthermore, as shown in the illustrated embodiment, the latch 220 extends from the periphery of the cover 202. As explained in more detail below, the first latch 220 and the second latch 220 are configured to engage with features (e.g., tabs) of the sidewall 25 of the tissue retainer 18 to securely attach to the tissue retainer 18, thereby allowing the cover 202 to retain the tissue sample within the tissue compartment 22.

[0073] like Figure 6B As shown, the tissue retainer 18 includes an edge having a top surface 222. The cover 202 of the tissue retainer cap 200 includes a sealing portion 224 extending circumferentially around the cover 200. The sealing portion 224 is configured to mate with the top surface 222 at the edge of the tissue retainer 18. The sealing portion 224 of the cover 202 has a bottom surface 226 for abutting against the top surface 222 of the edge of the tissue retainer 18.

[0074] In some embodiments, the partition wall 23 of the tissue retainer 18 may be shorter than the circumferential sidewall 25 of the tissue retainer 18. In these embodiments, the cover 202 may be configured to prevent tissue samples from migrating between tissue storage compartments during storage. For example, as Figure 6BAs shown, the sealing portion 224 of the cover 202 is raised or lifted relative to the central portion of the cover 202, such that the inner surface 203b of the cover 202 is lowered or recessed relative to the bottom surface 226 of the sealing portion 224. This allows the inner surface 203b of the cover 202 to engage with the partition wall 23 to minimize the gap formed between the cover 202 and the partition wall 23 and to prevent tissue samples in the tissue storage compartment 22 from migrating out of the tissue storage compartment 22. In some embodiments, the inner surface 203b may abut against the top side of the respective partition wall 23. In other embodiments, the inner surface 203b may not abut against the top side of the respective partition wall 23. Instead, the inner surface 203b may form a small gap with the top side of each of the partition walls 23. For example, in some embodiments, the inner surface 203b may be spaced from the top side of each of the partition walls 23 in the tissue retainer 18 by a distance of less than 0.1 inch, less than 0.05 inch, less than 0.04 inch, or less than 0.03 inch.

[0075] In other embodiments, the top of each partition wall 23 may be flush with the top surface 222 of the edge. In this case, the inner surface 203b of the cover 202 may be flush with the bottom surface 226 of the sealing portion 224.

[0076] In the illustrated embodiment, an opening 204 at the center of the cover 202 is configured to receive a post 230 of the tissue retainer 18. When the tissue retainer cap 200 is used to cover the tissue retainer 18, the cover 202 descends onto the tissue retainer 18, causing the post 230 to extend into the opening 204 of the cover 202. The post 230 serves as a guide to direct the cover 202 onto the tissue retainer 18, ensuring that the cover 202 is centered relative to the tissue retainer 18.

[0077] As shown, the post 230 of the tissue retainer 18 includes a plurality of recesses 232, and the tissue retainer cap 200 includes a first protrusion 206 and a second protrusion 206 that respectively mate with the recesses 232 of the post 230 of the tissue retainer 18. The protrusions 206 and recesses 232 allow the tissue retainer cap 200 to be selectively positioned relative to the tissue retainer 18 at one of a plurality of available angled positions. In the illustrated embodiment, the post 230 of the tissue retainer 18 has recesses 232 arranged circumferentially along the outer surface of the post 230. In other embodiments, the post 230 may have only two recesses (e.g., a first recess and a second recess arranged opposite to each other). Moreover, in the illustrated embodiment, the first protrusion 206 and the second protrusion 206 are located on opposite sides of the opening 204 of the cover 202. In other embodiments, the protrusions 206 may not be opposite to each other. Instead, they may be in other angled positions relative to each other. In other embodiments, the tissue retainer cap 202 may have more than two protrusions 206 or only one protrusion 206.

[0078] like Figure 6A As shown, the tissue retainer 18 includes a plurality of tabs 260 along the outer surface of the sidewall of the tissue retainer 18. When the tissue retainer cap 200 is placed on the tissue retainer 18, each latch 220 is configured (e.g., sized and / or positioned) to be received between two of the tabs 260. In the illustrated embodiment, each latch 220 is positioned relative to the protrusion 206 in a specific location, which allows the latch 220 to automatically align with the spacing between the two tabs 260 when the protrusion 206 is inserted into one of the recesses 232 at the post 230 of the tissue retainer 18. In the illustrated embodiment, each latch 220 is radially aligned with the corresponding protrusion 206. In other words, the latch 220 and the corresponding protrusion 206 are aligned along a radial line. This is because each recess 232 at the post 230 is also radially aligned with the spacing between the two tabs 260. In other embodiments, the latch 220 may not be radially aligned with the protrusion 206. For example, in other embodiments, each recess 232 at post 230 may not be aligned with the spacing between two of the tabs 260. In this case, the protrusion 206 and latch 220 of tissue retainer cap 200 may be positioned at an angle relative to each other, the angle corresponding to the angular offset between the recess 232 and the spacing between the two tabs 260.

[0079] In the illustrated embodiment, each latch 220 has a hook (anchor) 240 at the bottom end of the latch 220. Figure 6BEach latch 220 is configured to anchor against the bottom 21 of the tissue retainer 18 via a hook 240. Specifically, the latch 220 is configured to anchor against a corresponding bottom portion of the bottom 21. Each latch 220 can be elastically moved relative to the cover 202 (e.g., by flexing). This allows the latch 220 to flex radially outward in response to the hook 240 engaging the circumferential sidewall 25 of the tissue retainer 18 as the tissue retainer cap 200 descends relative to the tissue retainer 18. After the hook 240 has passed the bottom 21 of the tissue retainer 18, the latch 220 elastically returns to its stress-free state, and the hook 240 moves radially inward to anchor against the bottom 21 of the tissue retainer 18.

[0080] In the illustrated embodiment, the tissue retainer cap 200 further includes a protrusion 208 at the periphery 203 of the cover 202. The protrusion 208 has a corresponding vertical wall configured to be positioned between two adjacent tabs 260 of the tissue retainer 18. The protrusion 208 provides additional security against rotation of the tissue retainer cap 200 relative to the tissue retainer 18. In other embodiments, instead of having two protrusions 208, the tissue retainer cap 200 may have more than two protrusions 208 or only one protrusion 208. In yet another embodiment, the protrusion 208 is optional, and the tissue retainer cap 200 may not include any protrusions 208.

[0081] like Figure 6A As shown, the cover 202 also includes a plurality of vent holes 250 located between the periphery 203 of the cover 202 and the opening 204 of the cover 202. Each vent hole 250 extends through the thickness of the cover 202, thereby allowing air below the cover 202 to move through the cover 202 to the space above the cover 202. This is particularly useful when placing a tissue retainer 18 with an attached tissue retainer cap 200 into a formalin jar to preserve tissue samples. As the tissue retainer 18 sinks into the liquid within the formalin jar, the vent holes 250 allow air below the cover 202 to move through the cover 202 to the space above the cover. This has the technical effect of allowing the tissue retainer 250 (with the tissue retainer cap 200 attached thereto) to reach the bottom of the formalin jar more easily and efficiently. The vent holes 250 also allow tissue preservation fluid to enter the tissue retainer 18 to preserve tissue samples. Each vent 250 may have a cross-sectional dimension of less than 0.1 inches, or less than 0.05 inches, or less than 0.04 inches, or less than or equal to 0.03 inches.

[0082] It should be noted that the tissue retainer cap 200 is not limited to the above example, and the tissue retainer cap 200 may have other configurations in other embodiments.

[0083] Figures 7A to 7B Another tissue retainer cap 200 for covering the tissue retainer 18 according to other embodiments is shown. The tissue retainer cap 200 is compared with reference to... Figures 6A to 6B The descriptions are the same, but the difference is that... Figures 7A to 7B In the embodiments, the tissue retainer cap 200 has different types of latches. Specifically, such as... Figure 7A As shown, the tissue retainer cap 200 includes two latches 220 (a first latch and a second latch) that are engaged on opposite sides of the cover 202. The tissue retainer 18 includes a plurality of tabs 260 along its periphery. The latches 220 are configured to abut two of the tabs 260 located on opposite sides of the tissue retainer 18. In the illustrated embodiment, each latch 220 is configured to abut only one of the tabs 260. Each latch 220 has a latch opening 400 configured to receive one of the tabs 260.

[0084] Furthermore, each latch 220 has an anchoring surface 430 on one side of the opening 400. The anchoring surface 430 is configured to anchor against the bottom side 432 of one of the tabs 260. Figure 7B Each latch 220 can be elastically moved relative to the cover 202 (e.g., by flexing). This allows the latch 220 to flex radially outward in response to the tab 260 pressing against the vertical wall 434 of the latch 220 as the tissue retainer cap 200 descends relative to the tissue retainer 18. After the vertical wall 434 of the latch 220 has moved past the tab 260 of the tissue retainer 18, the vertical wall 434 moves radially inward to a position below the tab 260, and the latch 220 elastically returns to its stress-free state. When the vertical wall 434 is below the tab 260, the anchoring surface 430 of the latch abuts against the underside 432 of the tab 260, thereby anchoring the tissue retainer cap 200 relative to the tissue retainer 18.

[0085] In the illustrated embodiment, the tissue retainer cap 200 further includes a first finger-like tab 402 extending from the first latch 220 and a second finger-like tab 402 extending from the second latch 220. Each finger-like tab 402 extends radially away from the circumferential sidewall 25 and is located below the inner surface 203b of the cover 202 (see [link to documentation]). Figure 7B Each finger-like tab 402 is elastically deformable to move the corresponding latch 220 to unlock the tissue retainer cap 200 relative to the tissue retainer 18. Specifically, each finger-like tab 402 can be pulled to separate the anchoring surface 430 from the underside 432 of the tab 260. This also causes the opening 400 of the latch 220 to move upward relative to the tab 260, thereby separating the tissue retainer cap 200 from the tissue retainer 18.

[0086] In the illustrated embodiment, each latch 220 is positioned relative to the protrusion 206 in a specific location, which allows the latch 220 to automatically align with one of the tabs 260 when the protrusion 206 is inserted into one of the recesses 232 at the post 230 of the tissue retainer 18. In the illustrated embodiment, each latch 220 is radially aligned with its corresponding protrusion 206. In other words, the latch 220 and the corresponding protrusion 206 are aligned along a radial line. This is because each recess 232 at the post 230 is also radially aligned with one of the tabs 260. In other embodiments, the latch 220 may not be radially aligned with the protrusion 206. Additionally, in other embodiments, each recess 232 at the post 230 may not be aligned with one of the tabs 260. In this case, the protrusion 206 of the tissue retainer cap 200 and the latch 220 may be positioned at an angle relative to each other, the angle corresponding to an angular offset between the recess 232 and one of the tabs 260.

[0087] Figures 8A to 8F Another tissue retainer cap 200 for covering the tissue retainer 18 according to other embodiments is shown. The tissue retainer cap 200 is compared with reference to... Figures 6A to 6B The descriptions are the same, but the difference is that... Figures 8A to 8F In the embodiments, the tissue retainer cap 200 has different types of latches. Specifically, such as... Figures 8A to 8B As shown, the tissue retainer cap 200 includes two latches 220 (a first latch and a second latch) that are engaged on opposite sides of the cover 202. The tissue retainer 18 includes a plurality of tabs 260 along its periphery. The latches 220 are configured to anchor against two pairs of tabs 260 on opposite sides of the tissue retainer 18. In the illustrated embodiment, each latch 220 is configured to anchor against only two tabs 260.

[0088] like Figure 8E As shown, each latch 220 includes a first anchor 502 and a second anchor 504, which are configured to simultaneously abut two anchors in the tabs 260, respectively. Anchors 502 and 504 are configured to abut the underside anchors of two adjacent tabs 260, respectively (see [reference]). Figure 8A and Figure 8EEach latch 220 can be elastically moved relative to the cover 202 (e.g., by flexing). This allows the latch 220 to flex radially outward in response to the two adjacent tabs 260 pressing against the vertical walls of the respective anchors 502, 504 as the tissue retainer cap 200 descends relative to the tissue retainer 18. After the vertical walls of the respective anchors 502, 504 have moved past the tabs 260 of the tissue retainer 18, the vertical walls 434 move radially inward to a position below the tabs 260, and the latch 220 elastically returns to its stress-free state. When the anchors 502, 504 are below the tabs 260, they abut against the underside of the respective tabs 260, thereby anchoring the tissue retainer cap 200 relative to the tissue retainer 18.

[0089] In the illustrated embodiment, the tissue retainer cap 200 further includes a first finger-like tab 402 extending from the first latch 220 and a second finger-like tab 402 extending from the second latch 220. Each finger-like tab 402 extends upward and is located above the outer surface 203a of the cover 202 (see [link]). Figure 8C Each finger tab 402 is connected to the cover 202 via a resilient deformable joint 530, which allows the finger tab 402 to move the corresponding latch 220 to unlock the tissue retainer cap 200 relative to the tissue retainer 18. In particular, the finger tabs 402 can be pressed toward each other to cause the latch 220 to pivot about the joint 530, causing the latch 220 to move radially outward away from the circumferential sidewall 25, thereby disengaging the anchors 502, 504 from the tab 260.

[0090] In the illustrated embodiment, each latch 220 is positioned relative to the protrusion 206 in a specific location, which allows the latch 220 to automatically align with the gap 240 between two adjacent tabs 260 when the protrusion 206 is inserted into one of the recesses 232 at the post 230 of the tissue retainer 18. In the illustrated embodiment, each latch 220 is radially aligned with the corresponding protrusion 206. In other words, the latch 220 and the corresponding protrusion 206 are aligned along a radial line. This is because each recess 232 at the post 230 is also radially aligned with the corresponding space between two adjacent tabs 260. In other embodiments, the latch 220 may not be radially aligned with the protrusion 206. For example, in other embodiments, each recess 232 at the post 230 may not be aligned with the space between two adjacent tabs 260. In this configuration, the protrusion 206 and latch 220 of the tissue retainer cap 200 can be positioned at an angle relative to each other, the angle corresponding to the angular offset between the space between the two tabs in the recess 232 and the tab 260.

[0091] like Figures 8A to 8DAs shown, the tissue retainer cap 200 also includes stops 510 configured to prevent excessive deflection of the corresponding finger-like protrusions 402. Each stop 510 is in the form of a vertical structure (e.g., a rib) located behind the corresponding finger-like protrusion 402. The vertical structure (or rib) implementing the stop 510 extends from the protrusion 206. In other embodiments, the vertical structure may be shorter and may not extend from the protrusion 206. Each stop 510 is spaced from the finger-like protrusions 402 by a distance defining the range of movement of the finger-like protrusions 402. When a user presses the finger-like protrusions 402 radially toward the central axis of the tissue retainer cap 200, the finger-like protrusions 402 will move until they abut against the stop 510. In other embodiments, the stops 510 may have other constructions (e.g., shapes). For example, in other embodiments, each stop 510 may be in the form of a pillar, block, etc. In another embodiment, the tissue retainer cap 200 may not include any stop 510.

[0092] like Figure 8F As shown, each vent 250 has a cross-sectional dimension or diameter that decreases from the bottom side of the cover 202 toward the top side of the cover 202. The vent 250 allows air to escape but prevents tissue samples from escaping from the tissue holder 18. In other embodiments, the vent 250 may have a constant cross-sectional dimension extending through the thickness of the cover 202.

[0093] Figures 9A to 9C Another tissue retainer cap 200 for covering the tissue retainer 18 according to other embodiments is shown. The tissue retainer cap 200 is compared with reference to... Figures 8A to 8F The descriptions are the same, but the difference is that... Figures 9A to 9C In the embodiments, each of the latches 220 of the tissue retainer cap 200 has a rib 550 for reinforcing the latch 220. Specifically, as... Figures 9A to 9C As shown, the tissue retainer cap 200 includes two latches 220 (a first latch and a second latch) that are engaged on opposite sides of the cover 202. The tissue retainer 18 includes a plurality of tabs 260 along its periphery. The latches 220 are configured to anchor against two pairs of tabs 260 on opposite sides of the tissue retainer 18. In the illustrated embodiment, each latch 220 is configured to anchor against two tabs 260. In the illustrated embodiment, each latch has two vertical ribs 550 to increase the structural integrity of the latch 220. In other embodiments, each latch 220 may have more than two ribs 550 or only one rib 550. Moreover, in another embodiment, instead of one or more vertical ribs 550, each latch 220 may have one or more ribs oriented in other directions.

[0094] like Figure 9AAs shown, each latch 220 includes a first anchor 502 and a second anchor 504 configured to simultaneously abut against two of the tabs 260. Anchors 502 and 504 are configured to abut against the underside of two adjacent tabs 260. Each latch 220 can be elastically moved relative to the cover 202 (e.g., by flexure). This allows the latch 220 to flex radially outward in response to the two adjacent tabs 260 pressing against the vertical walls of the respective anchors 502 and 504 as the tissue retainer cap 200 descends relative to the tissue retainer 18. After the vertical walls of the respective anchors 502 and 504 have moved past the tabs 260 of the tissue retainer 18, the vertical walls 434 move radially inward to a position below the tabs 260, and the latch 220 elastically returns to its stress-free state. When the anchors 502 and 504 are below the tab 260, they abut against the bottom side of the respective tab 260, thereby anchoring the tissue retainer cap 200 relative to the tissue retainer 18.

[0095] In the illustrated embodiment, the tissue retainer cap 200 further includes a first finger-like tab 402 extending from the first latch 220 and a second finger-like tab 402 extending from the second latch 220. Each finger-like tab 402 extends upward and is located above the outer surface 203a of the cover 202 (see [link]). Figure 9A Each finger-like tab 402 is connected to the cover 202 via a resiliently deformable joint 530, which allows the finger-like tab 402 to move the corresponding latch 220 to unlock the tissue retainer cap 200 relative to the tissue retainer 18. Specifically, the finger-like tabs 402 can be pressed toward each other to pivot the latch 220 about the joint 530, causing the latch 220 to move radially outward away from the circumferential sidewall 25, thereby disengaging the anchors 502, 504 from the tab 260. As shown, each rib 550 extends to the finger-like tab 402, such that the rib 550 also strengthens the finger-like tab 402 (in addition to strengthening the latch 220).

[0096] In the illustrated embodiment, each latch 220 is positioned relative to the protrusion 206 in a specific location, which allows the latch 220 to automatically align with the gap 240 between two adjacent tabs 260 when the protrusion 206 is inserted into one of the recesses 232 in the post 230 of the tissue retainer 18. In the illustrated embodiment, the protrusions 206 and latches 220 of the tissue retainer cap 200 are positioned at an angle relative to each other, the angle corresponding to an angular offset between the recesses 232 and the spaces between the two tabs in the tabs 260. In other embodiments, the latches 220 may be radially aligned with the protrusions 206. In other words, the latches 220 and the corresponding protrusions 206 may be aligned with each other along a radial line.

[0097] like Figures 9A to 9C As shown, the tissue retainer cap 200 also includes stops 510 configured to prevent excessive deflection of the corresponding connector 530. Each stop 510 is in the form of a vertical structure located behind the corresponding finger protrusion 402. Each stop 510 is spaced apart from the finger protrusion 402 by a distance defining the range of movement of the finger protrusion 402. When a user presses the finger protrusion 402 radially toward the central axis of the tissue retainer cap 200, the finger protrusion 402 will move until it abuts against the stop 510. In other embodiments, the stops 510 may have other constructions (e.g., shapes). For example, in other embodiments, each stop 510 may be in the form of a pillar, block, etc. In yet another embodiment, the tissue retainer cap 200 may not include any stops 510.

[0098] like Figure 9A and Figure 9B As shown, the tissue retainer cap 200 also includes a rib 552 above the cover 202 for reinforcing the cover 202. The rib 552 provides additional stiffness to the cover 202, making it less prone to deformation. Although two ribs 552 are shown, in other embodiments, the tissue retainer cap 200 may have more than two ribs 552 or only one rib 552. Moreover, in other embodiments, the rib 552 may be in the form of a block rather than a planar structure.

[0099] like Figures 9A to 9B As shown, the cover 202 also includes a plurality of vent holes 250 located between the periphery 203 of the cover 202 and the opening 204 of the cover 202. Each vent hole 250 extends through the thickness of the cover 202, thereby allowing air below the cover 202 to move through the cover 202 to the space above the cover 202. This is particularly useful when placing a tissue retainer 18 with an attached tissue retainer cap 200 into a formalin jar to preserve tissue samples. As the tissue retainer 18 sinks into the liquid within the formalin jar, the vent holes 250 allow air below the cover 202 to move through the cover 202 to the space above the cover. This has the technical effect of allowing the tissue retainer 250 (with the tissue retainer cap 200 attached thereto) to reach the bottom of the formalin jar more easily and efficiently. The vent holes 250 also allow tissue preservation fluid to enter the tissue retainer 18 to preserve tissue samples. Each vent 250 may have a cross-sectional dimension of less than 0.1 inches, or less than 0.05 inches, or less than 0.04 inches, or less than or equal to 0.03 inches. (See reference...) Figure 8F As discussed similarly, Figures 9A to 9BIn one embodiment, each vent 250 has a cross-sectional dimension or diameter that decreases from the bottom side of the cover 202 toward the top side of the cover 202. The vent 250 allows air to escape but prevents tissue samples from escaping the tissue holder 18. In other embodiments, the vent 250 may have a constant cross-sectional dimension extending through the thickness of the cover 202.

[0100] Moreover, such as Figures 9A to 9B As shown, the cover 202 may include a plurality of small-diameter vents that can be patterned to align with the tissue storage compartment 22. The number and arrangement of the vents can vary. For example, the number of vents may increase from the opening 204 toward the sealing portion 224.

[0101] Figure 10 Another tissue retainer cap 200 for covering the tissue retainer 18 according to other embodiments is shown. The tissue retainer cap 200 is compared with reference to... Figures 6A to 8B The descriptions are the same, but the difference is that... Figure 10 In one embodiment, the tissue retainer cap 200 has four latches 220 configured to anchor against corresponding four tabs 260 at the circumferential sidewalls of the tissue retainer 18. As shown, two latches 220 in a first pair are radially aligned and arranged on opposite sides of the tissue retainer cap 200, and the other two latches 220 in a second pair are radially aligned and arranged on opposite sides of the tissue retainer cap 200. The four latches 220 are circumferentially spaced apart from each other, and each latch 220 is 90° apart from the adjacent latch 220. In other embodiments, there may be only two latches 220 or more than four latches 220. Moreover, in other embodiments, two latches 220 may not be radially aligned with each other. As shown, the tissue retainer cap 200 also includes ribs 552 on the outer surface of the cover 202. The ribs 552 are configured to reinforce the cover 202 to make it stiffer and / or stronger. To secure the tissue retainer cap 200 against the tissue retainer 18, the tissue retainer cap 200 is positioned around the post 230 of the tissue retainer 18 and lowered onto the edge of the tissue retainer 18. Each latch 220 is sized to fit between two adjacent tabs 260. Thus, the cover 202 of the tissue retainer cap 200 is lowered until the latches 220 have passed through the corresponding pairs of adjacent tabs 260. The tissue retainer cap 200 is then rotated about axis 253 to circumferentially rotate the four latches 220 to place the corresponding anchors of the latches 220 under the four corresponding tabs 260, thereby locking the tissue retainer cap 200 against the tissue retainer 18.

[0102] Figure 11Another tissue retainer cap 200 for covering the tissue retainer 18 according to other embodiments is shown. The tissue retainer cap 200 is compared with reference to... Figures 8A to 8F The description is the same, except that the tissue retainer cap 200 does not include the finger-like protrusions 402. Figure 11 In the illustrated embodiment, each latch 220 is configured to anchor against two tabs 260. In other embodiments, each latch 220 may have one or more vertical ribs (as shown in the reference). Figures 8A to 8F The described ribs 550 are used to increase the structural integrity of the latch 220. Furthermore, in another embodiment, instead of one or more vertical ribs 550, each latch 220 may have one or more ribs oriented in other directions. Figure 11 As shown, the tissue retainer cap 200 also includes ribs 552 on the outer surface of the cover 202. Ribs 552 are configured to reinforce the cover 202 to make it stiffer and / or stronger. To secure the tissue retainer cap 200 against the tissue retainer 18, the tissue retainer cap 200 is positioned around the post 230 of the tissue retainer 18 and descends onto the edge of the tissue retainer 18. Because the width of the latch 220 is wider than the spacing between adjacent tabs 260, the latch 220 is radially and resiliently pushed outward as it passes around the two tabs 260. After the latch 220 passes the two adjacent tabs 260, the latch 220 resiliently springs back radially to place the anchor under the adjacent tabs 260, thereby locking the tissue retainer cap 200 against the tissue retainer 18. To remove the tissue retainer cap 200 from the tissue retainer 18, the latch 220 can be pulled radially away from the circumferential sidewall 18 of the tissue retainer 18, and the tissue retainer cap 200 can then be lifted upward to remove it from the tissue retainer 18.

[0103] In one or more embodiments described herein, to further facilitate the immersion of a tissue retainer 18 with an attached tissue retainer cap 200 in a solution of tissue preservation fluid, the tissue retainer 18 may include a channel 18 for allowing air to escape from the tissue retainer. Figure 12A A bottom perspective view of a tissue retainer 18 according to some embodiments is shown. Figure 12B A top perspective view of the tissue retainer 18 is shown. Figures 12A to 12B As shown, the tissue retainer 18 includes: a bottom 21 having a filter 24, a circumferential sidewall 25 extending upward from the bottom 21, and a hub 38 having a cavity 600. The tissue retainer 18 also includes a plurality of partition walls 23 extending from the hub 38 to define a plurality of tissue storage compartments 22. The tissue retainer 18 also includes a column 230 extending upward from the hub 38. The tissue retainer 18 is similar to that previously referenced. Figures 1 to 11 The descriptions are the same, but the difference is that... Figures 12A to 12BThe tissue retainer 18 also includes a channel 610 extending from the cavity 600 of the hub 38 into the column 230, wherein the channel 610 is off-center relative to the column 230. The channel 610 is advantageous because it allows air trapped within the cavity 600 of the hub 38 to escape through the channel 610 into an open space outside the tissue retainer 18. Therefore, when the tissue retainer 18 with the attached tissue retainer cap 200 is placed in a solution of tissue preservation fluid (e.g., in a formalin container), the tissue retainer 18 with the tissue retainer cap 200 will not “float” but will easily and efficiently sink to the bottom of or into the solution of tissue preservation fluid.

[0104] It should be noted that the tissue retainer cap 200 is not limited to the examples described herein, and the tissue retainer cap 200 may have other configurations in other embodiments. For example, in other embodiments, the tissue retainer cap 200 may have more than two latches 220, one latch 220, or no latch. Moreover, in other embodiments, the latches 220 may have a different configuration than the described examples. Furthermore, in other embodiments, the tissue retainer cap 200 may have other types of securing mechanisms for removably abutting the tissue retainer cap 200 against the tissue retainer 18. For example, in other embodiments, the tissue retainer cap 200 may have a circumferential flange extending around the periphery of the cover 202. The circumferential flange is configured to removably snap onto the edge and / or tab 260 at the top of the circumferential sidewall 25 of the tissue retainer 18. In yet another embodiment, the tissue retainer cap 200 may include more than two protrusions 206, one protrusion 206, or may not include protrusions 206.

[0105] Furthermore, it should be noted that the tissue retainer 18 is not limited to the examples described herein, and the tissue retainer 18 may have other configurations in other embodiments. For example, in other embodiments, the tissue retainer 18 may not include the tab 260. Additionally, in other embodiments, the post 230 of the tissue retainer 18 may include more than two recesses 232, one recess 232, or may not include the recess 232.

[0106] In some embodiments, the tissue retainer cap 200 of any of the embodiments described herein may be combined with the tissue retainer 18 to provide a tissue storage system. Furthermore, in some embodiments, the tissue storage system may optionally include a container configured to house both the tissue retainer 18 and the tissue retainer cap 200. For example, the container may contain a tissue preservation fluid (e.g., formalin) or any other substance capable of preserving tissue samples. The container may also include a container cover for covering the container.

[0107] The method of disposing of a tissue sample using a tissue retainer 18 and a tissue retainer cap 200 will now be described. First, the tissue retainer 18, without the tissue retainer cap 200, is loaded into the tissue retainer assembly 10 of the tissue biopsy system 50 (see [link to documentation]). Figure 1 and Figure 4 While inside the tissue holder assembly 10, the tissue holder 18 rotates relative to the base 14 and the cover 16 of the tissue holder assembly 10 to sequentially receive tissue samples retrieved by the biopsy device 60 and to sequentially place the tissue samples at imaging positions relative to the imaging device 66 to allow the imaging device 66 to sequentially image the tissue samples. Figure 4 Specifically, after the biopsy device 60 retrieves a tissue sample from the patient, the tissue sample is transported into the tissue holder assembly 10 and stored in one of the tissue storage compartments 22 within the tissue holder 18. The tissue holder 18 is then rotated within the tissue holder assembly 10 to position the tissue sample in the imaging position. The imaging device 66 then images the tissue sample while it is in the imaging position. The biopsy device 60 also retrieves additional tissue samples from the patient and repeats the above steps until all tissue samples in the tissue holder 18 have been imaged.

[0108] After the tissue sample has been imaged, the tissue holder 18 can then be used to store the tissue sample. For this purpose, the cover 16 of the tissue holder assembly 10 is first removed from the base 14 to expose the tissue holder 18 therein. Then, the tissue holder cap 200 is placed on the tissue holder 18 and pushed down to secure the tissue holder cap 200 relative to the tissue holder 18. When the tissue holder cap 200 is secured against the tissue holder 18, the tissue holder cap and the tissue holder 18 cannot rotate relative to each other. The tissue holder 18 with the tissue holder cap 200 forms a tissue storage system, which is then removed from the base 14 of the tissue holder assembly 10.

[0109] The tissue retainer 18, with the tissue retainer cap 200 attached thereto, can then be placed in a container of tissue preservation fluid to store the tissue sample contained within the tissue retainer 18. In some cases, a canister of formalin may be used. In some cases, the tissue retainer 18 with the tissue retainer cap 200 may simply be placed on top of the tissue preservation fluid. Due to the vent 250 at the cover 202 of the tissue retainer cap 200, and also due to the channel 610 extending from the cavity 600 of the hub 38, air below the cover 202 and / or within the cavity 600 of the hub 38 can easily escape to the external environment. This allows the tissue retainer 18 with the attached tissue retainer cap 200 to be easily and efficiently immersed in the tissue preservation fluid. The tissue preservation fluid enters the tissue storage compartment 22 within the tissue retainer 18 from the bottom 21 (because it has a porous filter 24) and fills the tissue storage compartment 22 to preserve the tissue sample therein.

[0110] As illustrated in the above embodiments, the tissue retainer cap 200 is advantageous because it allows the tissue retainer 18, which is otherwise designed for use during imaging of the tissue sample, to be reused for the additional purpose of storing and separating the tissue sample after the imaging process is complete. Without the tissue retainer cap 200, clinicians would need to manually dispose of and process each tissue sample individually after imaging is complete in order to store all tissue samples. The tissue retainer cap 200 avoids this cumbersome and inefficient manual process by holding the tissue sample in the tissue retainer 18 while simultaneously immersing the tissue sample in tissue preservation fluid after imaging is complete.

[0111] Furthermore, the latch 220 described herein provides a frictional engagement with the tab 260 at the tissue retainer 18, thereby allowing the tissue retainer cap 200 to frictionally connect to the tissue retainer 18 for secure attachment. The frictional engagement between the latch 220 and the tab 260 also prevents rotation of the tissue retainer cap 200 relative to the tissue retainer 18. Moreover, in some embodiments, each latch 220 may be a snap-fit ​​latch. For example, each latch 220 may have one or more anchors that snap onto the tissue retainer 18 (e.g., snap onto one or more tabs 260 of the tissue retainer 18) when pushed down against the tissue retainer 18. In some embodiments, this feature provides an audible sound when the tissue retainer cap 200 is securely engaged with the tissue retainer 18, thereby informing the user that the tissue retainer cap 200 is secured relative to the tissue retainer 18 as desired.

[0112] A method for disposing of a tissue sample according to some embodiments will now be described. This method can be performed using the tissue retainer assembly 10 and tissue retainer cap 200 described herein. The method includes receiving a tissue sample by the tissue retainer, the tissue retainer having a plurality of tissue storage compartments, a hub, and a post extending from the hub, wherein the action of receiving the tissue sample is performed while the tissue retainer is movably located within the tissue retainer assembly. The method also includes receiving a first protrusion of the tissue retainer cap by a recess at a post of the tissue retainer to align a first latch of the tissue retainer cap with a first portion of the tissue retainer and align a second latch of the tissue retainer cap with a second portion of the tissue retainer. The method further includes securely attaching the tissue retainer cap to the tissue retainer to retain the tissue sample within the tissue storage compartment of the tissue retainer, wherein the action of secure attachment is performed by the first and second latches of the tissue retainer cap abutting against the tissue retainer anchorage.

[0113] Optionally, in this method, the first portion of the tissue retainer includes a first protrusion at the circumferential sidewall of the tissue retainer, and the second portion of the tissue retainer includes a second protrusion at the circumferential sidewall of the tissue retainer.

[0114] Optionally, in this method, the first portion of the tissue retainer includes a first pair of tabs on the circumferential sidewall of the tissue retainer, and the second portion of the tissue retainer includes a second pair of tabs on the circumferential sidewall of the tissue retainer.

[0115] Optionally, in this method, the first portion of the tissue retainer includes a first bottom of the tissue retainer, and the second portion of the tissue retainer includes a second bottom of the tissue retainer.

[0116] Although specific embodiments have been shown and described, it will be understood that the claimed invention is not intended to be limited to the preferred embodiments, and it will be apparent to those skilled in the art that various changes and modifications can be made without departing from the scope of the claimed invention. Accordingly, the specification and drawings are to be considered illustrative rather than restrictive. The claimed invention is intended to cover alternatives, modifications, and equivalents.

Claims

1. A tissue storage system comprising a tissue retainer (18) and a tissue retainer cap (200) for covering the tissue retainer. The tissue retainer (18) has a bottom (21), a circumferential sidewall (25) extending upward from the bottom (21), a hub (38), a column (230) extending upward from the hub (38), and a plurality of partition walls (23) extending radially outward from the hub (38) to define a plurality of tissue storage compartments (22). The tissue retainer cap (200) includes: A cover (202) having a periphery, the cover (202) having an outer surface (203a) and an inner surface (203b) opposite to the outer surface (203a), wherein the central portion of the cover includes an opening (204) configured to receive the column (230) of the tissue retainer (18). A first latch (220) extends from the periphery of the cover (202); as well as A second latch extends from the periphery of the cover (202) and is circumferentially spaced from the first latch (220); The column includes multiple recesses (232). The cover (202) includes a first protrusion (206) configured to engage the post (230) of the tissue retainer (18), and wherein when the first protrusion (206) engages with the post (230), each of the first latch (220) and the second latch automatically aligns with one or more of a plurality of tabs (260) located on the circumferential sidewall (25) of the tissue retainer (18) to securely fasten the tissue retainer cap (200) to the tissue retainer (18). The cover (202) further includes a second protrusion, wherein the first protrusion (206) and the second protrusion are configured to engage with a first recess and a second recess of the plurality of recesses (232) of the column of the tissue retainer, respectively.

2. The organization storage system of claim 1, wherein, The cover (202) of the tissue retainer cap (200) includes a sealing portion (224) extending circumferentially around the cover (202), the sealing portion (224) having a bottom surface (226) for abutting against the edge of the circumferential sidewall (25) of the tissue retainer (18), and wherein the inner surface (203b) of the cover (202) is recessed relative to the bottom surface (226) of the sealing portion (224).

3. The tissue storage system of claim 1, wherein, The first protrusion (206) of the tissue retainer cap (200) is configured to be placed in a first recess (232) in the post (230) of the tissue retainer (18) when the first protrusion (206) engages with the post (230).

4. The tissue storage system of claim 1, wherein the first protrusion and the second protrusion are located on opposite sides of the opening of the cover.

5. The tissue storage system according to claim 1, wherein, The first latch (220) is elastically movable relative to the cover (202).

6. The tissue storage system of claim 1, further comprising a first finger-like protrusion (402) extending from the first latch (220), wherein the first finger-like protrusion (402) is configured to move the first latch (220) for separating the tissue retainer cap (200) from the tissue retainer (18), and The tissue storage system also includes a stop (510) configured to prevent excessive flexure of the first finger-like protrusion (402).

7. The tissue storage system according to claim 1, wherein, The first latch (220) is configured to anchor against the bottom (21) of the tissue retainer (18).

8. The tissue storage system according to claim 1, wherein, The first latch (220) is configured to anchor against one of the plurality of tabs (260) on the circumferential sidewall (25) of the tissue retainer (18), and wherein the first latch (220) includes a latch opening (400) configured to receive a corresponding one of the tabs (260).

9. The tissue storage system according to claim 1, wherein, The first latch (220) includes a first anchor (502) and a second anchor (504), the first anchor (502) and the second anchor (504) being configured to simultaneously abut against adjacent tabs of the plurality of tabs (260) on the circumferential sidewall (25) of the tissue retainer (18) for anchoring.

10. The tissue storage system according to claim 1, wherein, The cover (202) includes a plurality of vent holes (250) located between the periphery of the cover and the opening of the cover (202).

11. The tissue storage system of claim 1, wherein each pair of adjacent tabs (260) of the tissue retainer (18) defines a space between the adjacent tabs, and wherein the space or one of the tabs (260) is radially aligned with the first recess (232) of the post (230) of the tissue retainer (18).

12. The tissue storage system according to claim 1, wherein, The tissue retainer (18) also includes a channel (610) extending from the cavity (600) of the hub (38) into the post (230), wherein the channel (610) is off-center relative to the post (230).

13. The tissue storage system according to claim 4, wherein, The first latch (220) is radially aligned with the first protrusion (206).

14. The tissue storage system according to claim 10, wherein, At least one of the plurality of vents has a cross-sectional dimension of no more than 0.03 inches.

15. The tissue storage system according to claim 10, wherein, At least one of the plurality of vent holes has a cross-sectional dimension that increases along the thickness of the cover.

16. The tissue storage system according to claim 10, wherein, The density of the plurality of vent holes increases as a function of the distance from the opening.

17. A method for disposing of a tissue sample, the method comprising: The tissue sample is received in a tissue holder (18) having a plurality of tissue storage compartments (22), a hub (38) and a post (230) extending from the hub, the post including a plurality of recesses (232), wherein the tissue sample is received in a corresponding tissue storage compartment of the plurality of tissue storage compartments (22) while the tissue holder (18) is located within the tissue holder assembly (10); The first protrusion (206) of the tissue retainer cap (200) is received at the first recess of the plurality of recesses (232) in the post of the tissue retainer (18), thereby aligning the first latch (220) of the tissue retainer cap (200) with the first portion of the tissue retainer (18), and the second protrusion of the tissue retainer cap (200) is received at the second recess of the plurality of recesses (232) in the post of the tissue retainer (18), thereby aligning the second latch of the tissue retainer cap (200) with the second portion of the tissue retainer (18); as well as The tissue retainer cap (200) is securely attached to the tissue retainer (18) to hold the tissue sample within the corresponding tissue storage compartment (22), wherein the secure attachment is performed by anchoring the tissue retainer (18) against the first latch (220) and the second latch of the tissue retainer cap (200).

18. The method according to claim 17, wherein, The first portion of the tissue retainer (18) includes a first tab (260) on the circumferential sidewall (25) of the tissue retainer (18), and the second portion of the tissue retainer (18) includes a second tab (260) on the circumferential sidewall (25) of the tissue retainer (18), and / or The first portion of the tissue retainer (18) includes a first pair of tabs (260) on the circumferential sidewall (25) of the tissue retainer (18), and the second portion of the tissue retainer (18) includes a second pair of tabs (260) on the circumferential sidewall (25) of the tissue retainer (18).

19. The method of claim 17, wherein, The first portion of the tissue retainer (18) includes a first bottom portion (21) of the tissue retainer (18), and the second portion of the tissue retainer (18) includes a second bottom portion (21) of the tissue retainer (18).

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