Sample analyzer

Abstract

The present invention discloses a sample analyzer, which includes a housing, a separation module, a detection module and a transfer module. The housing is provided with an installation cavity and an injection port connected to the installation cavity. The housing is also provided with an injection platform corresponding to the injection port. The injection platform is used to place the sample to be tested. The separation module is arranged in the installation cavity. The separation module is provided with a separation cavity. The separation cavity is used to accommodate the sample to be tested. The separation module is used to separate the sample to be tested. The detection module is arranged in the installation cavity and is located on the side of the separation module away from the injection port. The detection module is used to detect the sample to be tested. The transfer module is arranged in the installation cavity. The transfer module is used to transfer the sample to be tested on the injection platform to the separation cavity or the detection module. The present invention aims to provide a sample analyzer that integrates centrifugal separation and detection. The sample analyzer not only simplifies the manual operation steps, but also effectively reduces the biosafety risk of sample contamination, while shortening the detection time.

Description

Technical Field

[0001] The present invention relates to the technical field of blood sample detection equipment, and in particular to a sample analyzer. Background Art

[0002] Blood is one of the most commonly used samples for clinical testing. Through biochemical, immunological and other testing methods, various physiological and pathological information of the subjects can be obtained from the blood, providing a basis for clinical diagnosis and treatment. Currently, most blood tests require the separation of blood components during the blood sample pretreatment stage, and then subsequent testing of the separated blood components.

[0003] In the related art, the detection equipment does not have a separation function, and the separation of blood requires a separate separation mechanism. The separated serum and plasma are then placed in the detection equipment for detection. This not only makes the operation cumbersome, but also increases the biosafety risk of sample contamination and prolongs the detection time. Summary of the invention

[0004] The main purpose of the present invention is to provide a sample analyzer, aiming to provide a sample analyzer that integrates centrifugal separation and detection. The sample analyzer not only simplifies the manual operation steps, but also effectively reduces the biosafety risk of sample contamination, while shortening the detection time.

[0005] To achieve the above object, the present invention provides a sample analyzer, the sample analyzer comprising:

[0006] A housing, wherein the housing is provided with a mounting cavity and an injection port connected to the mounting cavity, and the housing is further provided with an injection platform corresponding to the injection port, and the injection platform is used to place a sample to be tested;

[0007] A separation module, the separation module is arranged in the installation cavity, the separation module is provided with a separation cavity, the separation cavity is used to accommodate the sample to be tested, and the separation module is used to separate the sample to be tested;

[0008] A detection module, the detection module is arranged in the installation cavity and located at a side of the separation module away from the injection port, the detection module is used to detect the sample to be tested; and

[0009] A transfer module is disposed in the installation cavity and is used to transfer the sample to be tested on the injection station to the separation cavity or the detection module.

[0010] In one embodiment, the transfer module comprises:

[0011] A first sampling assembly, the first sampling assembly is disposed in the installation cavity and is opposite to the separation module. The first sampling assembly includes a first frame body disposed on the housing, a first driving assembly, and a first sampling needle. The first driving assembly is connected to the first frame body, and the first sampling needle is connected to the first driving assembly. The first driving assembly is configured to drive the first sampling needle to reciprocate between the sample injection table and the separation cavity to aspirate and transfer the sample to be tested; and

[0012] A second sampling assembly, the second sampling assembly is disposed in the installation cavity. The second sampling assembly is opposite to and spaced apart from the first sampling assembly. The second sampling assembly includes a second frame body disposed on the housing, a second driving assembly, and a second sampling needle. The second driving assembly is connected to the second frame body, and the second sampling needle is connected to the second driving assembly. The second driving assembly is configured to drive the second sampling needle to reciprocate between the sample injection table or the separation cavity and the detection module to aspirate and transfer the separated sample to be tested.

[0013] In one embodiment, the housing is further provided with a reagent inlet communicating with the installation cavity. The reagent inlet is disposed adjacent to the second sampling assembly. The sample analyzer further includes a reagent storage, the reagent storage is connected to the housing and is located at the reagent inlet. The reagent storage is configured to place reaction reagents.

[0014] In one embodiment, the reagent storage includes:

[0015] A movable member, the movable member is movably connected to the housing and is located at the reagent inlet; and

[0016] A placement tray, the placement tray is detachably disposed on the movable member. The placement tray is configured to place reaction reagents;

[0017] Wherein, the movable member drives the placement tray to enter or exit the installation cavity from the reagent inlet, so that the placement tray is located on the moving path of the second sampling needle between the sample injection table and the detection module, and the second driving assembly drives the second sampling needle to reciprocate between the placement tray and the detection module.

[0018] In one embodiment, the detection module includes:

[0019] A rotation driving member, the rotation driving member is disposed in the installation cavity;

[0020] A rotating table, the rotating table is rotatably disposed in the installation cavity and is connected to the rotation driving member. The rotating table is provided with a reaction station and a detection station;

[0021] A detection module, the detection module is disposed on one side of the rotating table;

[0022] A cup feeding assembly, which is arranged in the installation cavity and is adjacent to the first sampling assembly. The cup feeding assembly is provided with a cup placing cavity, a conveying channel and a cup outlet. Two ends of the conveying channel are respectively communicated with the cup placing cavity and the cup outlet, and the cup outlet is arranged corresponding to the rotary table.

[0023] Wherein, the rotary driving part drives the rotary table to rotate, so that the detection station corresponds to the detection module, and the reaction station corresponds to the cup outlet.

[0024] In one embodiment, the machine shell is further provided with a replacement opening communicating with the installation cavity, and the replacement opening corresponds to the separation module. The separation module includes:

[0025] A third frame body, which is arranged in the installation cavity and corresponds to the replacement opening. The third frame body is provided with an installation groove.

[0026] A separation driving part, which is arranged on a side of the third frame body facing away from the installation groove, and an output shaft of the separation driving part penetrates through the bottom wall of the installation groove; and

[0027] A separation disc, which is movably arranged in the installation groove and is detachably connected to the output shaft of the separation driving part. The separation disc is provided with the separation cavity.

[0028] Wherein, the separation driving part drives the separation disc to rotate, so as to separate the sample to be detected in the separation cavity.

[0029] In one embodiment, the third frame body includes an installation frame and a separation seat. The installation frame is arranged in the installation cavity and corresponds to the replacement opening. The installation frame is provided with a sliding rail, and the separation seat is slidably connected to the sliding rail. The separation seat is provided with the installation groove, and the separation driving part is arranged on a side of the separation seat facing away from the installation groove.

[0030] The separation module further includes a replacement driving part, which is arranged on the installation frame and is connected to the separation seat. The replacement driving part drives the separation seat to drive the separation disc to enter or exit the installation cavity.

[0031] In one embodiment, the machine shell is further provided with a movable baffle corresponding to the replacement opening. The movable baffle is movably connected to the machine shell to open or close the replacement opening;

[0032] And / or, the machine shell is further provided with a placement rack adjacent to the replacement opening. The placement rack is provided with a placement cavity for placing the separation disc.

[0033] And / or, the housing is further provided with a waste port communicating with the installation cavity. The waste port is adjacent to the replacement port and corresponds to the detection module. The sample analyzer further includes a waste collection box detachably disposed at the waste port for collecting the waste after being detected by the detection module.

[0034] In one embodiment, the sample to be tested is provided with an identification code. The sample analyzer further includes a detection component disposed on the housing and corresponding to the sample introduction platform. The first sampling component and the second sampling component are located on opposite sides of the detection component. The detection component is used to detect the identification code of the sample to be tested.

[0035] In one embodiment, the sample introduction platform is provided with a puncture position and a sampling position. The puncture position corresponds to the first sampling component, and the sampling position corresponds to the second sampling component.

[0036] In one embodiment, the sample introduction platform is further provided with a circulating sample introduction channel extending from the sampling position to the puncture position;

[0037] And / or, the sample introduction platform is further provided with an emergency position adjacent to the puncture position.

[0038] In one embodiment, the sample analyzer further includes a mixing component, and the mixing component includes:

[0039] A fixing frame disposed in the installation cavity and adjacent to the sample inlet;

[0040] A mixing driving member disposed on the fixing frame; and

[0041] A mixing jaw connected to the output shaft of the mixing driving member, and the mixing jaw is provided with a clamping groove;

[0042] Wherein, the mixing driving member drives the mixing jaw to clamp the sample to be tested in the clamping groove for mixing.

[0043] In one embodiment, the sample analyzer further includes a controller and a display screen disposed on the housing. The display screen is adjacent to the sample inlet. The controller is electrically connected to the display screen, the separation module, the detection module, and the transfer module.

[0044] The sample analyzer of the technical solution of the present invention sets an installation cavity inside the casing, so as to install, fix and protect the separation module, the detection module and the transfer module by using the installation cavity, ensuring that the sample introduction, separation and detection steps are all carried out inside the installation cavity, thereby effectively reducing the biosafety risk of sample contamination; by setting a sample inlet communicating with the installation cavity on the casing and arranging a sample inlet table corresponding to the sample inlet, it is convenient to place or store the sample to be tested by using the sample inlet table, and at the same time, it is convenient for the transfer module to sample the sample to be tested on the sample inlet table through the sample inlet; by integrating the separation module, the detection module and the transfer module into the installation cavity of the casing at the same time, when the sample analyzer realizes sample introduction through the transfer module, it is also convenient to use the separation module to perform centrifugal separation on the sample to be tested placed in the separation cavity, so as to facilitate the detection module to detect the separated sample to be tested. In this way, the manual operation steps are simplified and the detection time is shortened. It can be understood that by reasonably arranging the separation module, the detection module and the transfer module in the installation cavity of the casing, the volume of the sample analyzer is not increased, and the layout in the installation cavity of the casing is more compact. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on the structures shown in these drawings without creative efforts.

[0046] Figure 1 It is a schematic structural diagram of a sample analyzer in an embodiment of the present invention;

[0047] Figure 2 It is a schematic structural diagram of the sample analyzer from another perspective in an embodiment of the present invention;

[0048] Figure 3 It is a schematic structural diagram of the sample analyzer with the outer shell removed in an embodiment of the present invention;

[0049] Figure 4 It is a schematic structural diagram of the sample analyzer from another perspective with the outer shell removed in an embodiment of the present invention;

[0050] Figure 5 It is a schematic structural diagram of the sample analyzer with the casing removed in an embodiment of the present invention;

[0051] Figure 6 It is a schematic top view structural diagram of the sample analyzer with the casing removed in an embodiment of the present invention.

[0052] Explanation of the reference numerals in the drawings:

[0053] Label Name Label Name Label Name 100 Sample analyzer 22 Separation base 413 First sampling needle 1 Machine housing 221 Installation groove 42 Second sampling component 11 Installation cavity 24 Separation disc 421 Second frame 12 Base 241 Sample addition position 422 Second drive component 121 Sampling table 242 Sampling position 423 Second sampling needle 13 Side plate 3 Detection module 5 Reagent warehouse 131 Sampling inlet 31 Rotation drive part 51 Movable part 132 Reagent inlet 32 Rotating table 52 Placement tray 133 Replacement opening 33 Detection module 53 Reaction reagent 134 Movable baffle 34 Cup feeding component 6 Detection part 135 Waste opening 341 Cup placement cavity 7 Mixing component 14 Top plate 342 Transport channel 71 Fixing frame 15 Sample to be tested 343 Cup outlet 72 Mixing drive part 16 Waste collection box 4 Transfer module 73 Mixing gripper 2 Separation module 41 First sampling component 74 Clamping groove 21 Mounting bracket 411 First frame 81 Controller 211 Sliding rail 412 First drive component 82 Display screen

[0054] The realization, functional features and advantages of the present invention will be further described in conjunction with the embodiments and with reference to the accompanying drawings. Specific embodiments

[0055] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the scope of protection of the present invention.

[0056] It should be noted that all directional indications (such as up, down, left, right, front, back...) in the embodiments of the present invention are only used to explain the relative positional relationship and movement conditions between components in a specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indications will also change accordingly.

[0057] At the same time, the meaning of "and / or" or "and / or" that appears throughout the text is that it includes three solutions. Taking "A and / or B" as an example, it includes solution A, or solution B, or a solution where A and B are satisfied simultaneously.

[0058] In addition, the descriptions such as "first" and "second" in the present invention are only for descriptive purposes, and cannot be understood as indicating or implying their relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one of such features. In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement it. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0059] Blood is one of the most commonly used samples in clinical tests. Through various detection means such as biochemistry and immunology, various physiological and pathological information of the test subject can be obtained from the blood, providing a basis for clinical diagnosis and treatment. Currently, most detections of blood require separating the components of the blood in the blood sample pretreatment stage, and then performing subsequent detections on the separated blood components.

[0060] In the related art, the detection device does not have a separation function. The separation of blood requires a separate separation mechanism for separation. The separated serum and plasma are then put into the detection device for detection. This increases the manual opening operation, not only making the operation cumbersome, but also increasing the biosafety risk of contamination and the risk of sample misalignment and confusion. At the same time, it increases the waiting and transportation time from the centrifuge to the instrument, thus prolonging the total time from receiving the sample to obtaining the detection result.

[0061] Based on the above concepts and problems, the present invention proposes a sample analyzer 100. It can be understood that the sample analyzer 100 is used to detect blood samples. The blood sample can be one or more of body fluids such as whole blood samples, serum samples, plasma samples, blood cell samples, hemoglobin samples, urine, etc. In the present embodiment, the blood sample can be stored or contained in a reaction container, and the reaction container can be a round tube reaction cup, an inner octagonal round tube reaction cup, a vacuum blood collection tube, a micro vacuum blood collection tube, a square tube reaction cup, etc., which are not limited here. Of course, the reaction container not only includes reaction cups for luminescence, but also includes reaction cups used for several other instruments, such as blood cells, biochemistry, coagulation, etc., that is, the sample analyzer 100 can be applied to the fields of blood cells, biochemistry, coagulation, etc., which are not limited here.

[0062] It is understandable that a whole blood sample is used as the blood sample to be separated, because the density of the components in the blood sample is greater than the density of the plasma or serum components, and thus a plasma or serum sample can be obtained by centrifugation for the next step of analysis; wherein the sample to be tested is a serum or plasma sample. In this embodiment, the sample to be tested 15 can be one or more of a whole blood sample, a serum sample, a plasma sample, a blood cell sample, and a hemoglobin sample, which are not limited here.

[0063] Please refer to Figures 1 to 6 As shown, in an embodiment of the present invention, the sample analyzer 100 includes a housing 1, a separation module 2, a detection module 3 and a transfer module 4, wherein the housing 1 is provided with an installation cavity 11 and an injection port 131 connected to the installation cavity 11, and the housing 1 is further provided with an injection table 121 corresponding to the injection port 131, and the injection table 121 is used to place the sample to be tested 15, the separation module 2 is arranged in the installation cavity 11, the separation module 2 is provided with a separation cavity, the separation cavity is used to accommodate the sample to be tested 15, the separation module 2 is used to separate the sample to be tested 15, the detection module 3 is arranged in the installation cavity 11, and is located on the side of the separation module 2 away from the injection port 131, the detection module 3 is used to detect the sample to be tested 15, the transfer module 4 is arranged in the installation cavity 11, and the transfer module 4 is used to transfer the sample to be tested 15 on the injection table 121 to the separation cavity or the detection module 3.

[0064] In this embodiment, the housing 1 is used to install, fix and support the separation module 2, the detection module 3 and the transfer module 4, that is, the housing 1 provides a mounting base for the separation module 2, the detection module 3 and the transfer module 4. It can be understood that in order to ensure that the sample is not contaminated during the injection, separation and detection processes, the mounting cavity 11 of the housing 1 can be selected as a closed space.

[0065] Understandable, such as Figures 1 to 6As shown in the figure, the housing 1 includes a base 12, side plates 13 and a top plate 14. The side plates 13 are provided at the periphery of the base 12. The top plate 14 is opposite to the base 12 and is connected to one end of the side plates 13 away from the base 12, so that the base 12, the side plates 13 and the top plate 14 enclose a sealed installation cavity 11. Optionally, the side plates 13 include a front side plate, a left side plate, a right side plate and a rear side plate. The front side plate, the left side plate, the right side plate and the rear side plate are connected in sequence, and one end is connected to the four sides of the base 12, and the other end is connected to the four side plates of the top plate 14.

[0066] In this embodiment, as Figures 1 to 6 described, the sample inlet 131 is opened on the front side plate of the side plate 13. The sample inlet table 121 extends from the base 12 and protrudes from the front side plate of the side plate 13. It can be understood that the sample inlet table 121 is used to place the sample to be tested 15. For the convenience of placing the sample to be tested 15, the sample inlet table 121 is provided with a placement rack, and the placement rack is provided with a limiting groove for accommodating and limiting the sample to be tested 15.

[0067] It can be understood that in order to detect multiple samples to be tested 15 in sequence and facilitate the distinction between untested samples and tested samples, the sample inlet table 121 includes a to-be-tested area and a tested area on both sides of the sample inlet 131 and a detection area corresponding to the sample inlet 131. In this embodiment, a driving mechanism is provided in the sample inlet table 121 to drive the sample to be tested 15 in the to-be-tested area to move from the detection area to the tested area. The driving mechanism can be a conveyor belt, a conveying mechanism or other structures capable of realizing the transfer of the sample to be tested 15, which is not limited herein. Optionally, the sample inlet table 121 is provided with a sampler, which is a mechanism for realizing the cyclic sampling of the sample to be tested 15, which is not limited herein.

[0068] In this embodiment, as Figures 2 to 6 shown, the separation module 2 is arranged on the base 12 of the housing 1. The separation module 2 is provided with a separation cavity for accommodating and separating the sample to be tested 15. The separation module 2 is used to separate the sample to be tested 15. It can be understood that the separation module 2 can be a separator, a separation disk, a centrifuge cup, a centrifugal microfluidic chip or other structures capable of realizing liquid centrifugal separation, which is not limited herein.

[0069] It can be understood that the detection module 3 is arranged on the base 12 and the side plate 13 / top plate 14 of the housing 1. The detection module 3 is used to detect the separated sample to be tested 15 or one or more of serum samples, plasma samples, blood cell samples, and hemoglobin samples. In this embodiment, the transfer module 4 can be arranged on the side plate 13 / top plate 14 of the housing 1 and is spaced and opposite to the separation module 2 and the detection module 3, so that it is convenient for the transfer module 4 to transfer the sample to be tested 15 on the sample inlet table 121 to the separation cavity or the detection module 3.

[0070] In this embodiment, when the sample 15 to be tested needs to be separated, the transfer module 4 transfers the sample 15 on the sampling table 121 to the separation chamber for centrifugal separation. After the separation is completed, the transfer module 4 transfers the sample separated in the separation chamber to the detection module 3 for detection. Of course, when the sample 15 to be tested does not need to be separated, the transfer module 4 directly transfers the sample 15 on the sampling table 121 to the detection module 3, so that the detection module 3 can detect the sample 15 to be tested. In this way, the sample analyzer 100 can be applicable to the detection of various samples, improving the versatility.

[0071] The sample analyzer 100 of the present invention sets an installation cavity 11 in the housing 1, so as to use the installation cavity 11 to install, fix and protect the separation module 2, the detection module 3 and the transfer module 4, so as to ensure that the sample introduction, separation and detection steps are all carried out in the installation cavity 11, thereby effectively reducing the biosafety risk of sample contamination; by setting a sample inlet 131 communicating with the installation cavity 11 on the housing 1 and setting a sampling table 121 corresponding to the sample inlet 131, it is convenient to place or store the sample 15 to be tested by using the sampling table 121, and at the same time, it is convenient for the transfer module 4 to sample the sample 15 to be tested on the sampling table 121 through the sample inlet 131; by integrating the separation module 2, the detection module 3 and the transfer module 4 in the installation cavity 11 of the housing 1 at the same time, when the sample analyzer 100 realizes sample introduction through the transfer module 4, it is also convenient to use the separation module 2 to perform centrifugal separation on the sample 15 to be tested placed in the separation chamber, so as to facilitate the detection module 3 to detect the separated sample to be tested. In this way, the manual operation steps are simplified and the detection time is shortened. It can be understood that by reasonably arranging the separation module 2, the detection module 3 and the transfer module 4 in the installation cavity 11 of the housing 1, the volume of the sample analyzer 100 is not increased, and the layout in the installation cavity 11 of the housing 1 is more compact.

[0072] In one embodiment, the transfer module 4 includes a first sampling component 41 and a second sampling component 42. Among them, the first sampling component 41 is disposed in the installation cavity 11 and is opposite to the separation module 2. The first sampling component 41 includes a first frame body 411, a first driving component 412 and a first sampling needle 413 disposed on the machine shell 1. The first driving component 412 is connected to the first frame body 411, and the first sampling needle 413 is connected to the first driving component 412. The first driving component 412 is used to drive the first sampling needle 413 to reciprocate between the sample injection table 121 and the separation cavity to aspirate and transfer the sample to be tested 15. The second sampling component 42 is disposed in the installation cavity 11. The second sampling component 42 is opposite to and spaced apart from the first sampling component 41. The second sampling component 42 includes a second frame body 421, a second driving component 422 and a second sampling needle 423 disposed on the machine shell 1. The second driving component 422 is connected to the second frame body 421, and the second sampling needle 423 is connected to the second driving component 422. The second driving component 422 is used to drive the second sampling needle 423 to reciprocate between the sample injection table 121 or the separation cavity and the detection module 3 to aspirate and transfer the separated sample to be tested 15.

[0073] In this embodiment, as Figures 3 to 6 shown, the first sampling component 41 and the second sampling component 42 of the transfer module 4 are disposed in the installation cavity 11 of the machine shell 1. Optionally, the first sampling component 41 and the second sampling component 42 are respectively fixed on the left side plate and the right side plate of the side plate 13, so that the first sampling component 41 and the second sampling component 42 are located on opposite sides of the separation module 2. In this way, different samples can be injected through the first sampling component 41 and the second sampling component 42 respectively. Of course, the second sampling component 42 is located on the right side of the separation module 2, and the first sampling component 41 can be located above the separation module 2, or can be set to be left or right offset, which is not limited herein.

[0074] It can be understood that the first frame body 411 of the first sampling component 41 is fixed to the left side plate of the side plate 13 to provide a mounting, fixing and moving guiding basis for the first driving component 412 and the first sampling needle 413. In this embodiment, the first frame body 411 is provided with a slide rail that extends from the sample injection port 131 to the detection module 3. The first driving component 412 is slidably connected to the slide rail. The first driving component 412 can be a driving module. In order to facilitate sampling and sample placement, the first driving component 412 can drive the first sampling needle 413 to move in two-dimensional or three-dimensional directions, such as the two-dimensional direction of the X axis and the Z axis or the three-dimensional direction of the X axis, the Y axis and the Z axis, which is not limited herein. Of course, the first frame body 411 can be a support structure with structures such as installation grooves, guide rails, and lead screws installed or provided. Optionally, the first frame body 411 and the side plate 13 of the machine shell 1 can be connected in a detachable manner or integrally, which is not limited herein.

[0075] In this embodiment, the first sampling needle 413 can be a puncture whole blood sampling needle, a two-dimensional needle mechanism for puncturing a test tube and then transferring a whole blood sample. The sample to be tested 15 can be a whole blood sample with a cap. The sealed whole blood sampling tube with a test tube cap is placed on the sampling table 121, and the whole blood sample is transferred after puncturing by the puncture sampling needle capable of two-dimensional movement.

[0076] It can be understood that the second frame 421 of the second sampling assembly 42 is fixed to the right side plate of the side plate 13 to provide a mounting, fixing, and movement guiding basis for the second driving assembly 422 and the second sampling needle 423. In this embodiment, the second frame 421 is provided with a slide rail that extends from the sample inlet 131 to the detection module 3. The second driving assembly 422 is slidably connected to the slide rail. The second driving assembly 422 can drive the module. To facilitate sampling and sample placement, the second driving assembly 422 can drive the second sampling needle 423 to move in two-dimensional or three-dimensional directions, such as the two-dimensional direction of the X-axis and the Z-axis or the three-dimensional direction of the X-axis, Y-axis, and Z-axis, which is not limited herein. Of course, the second frame 421 can be a bracket structure with installation grooves, guide rails, lead screws, etc. installed or provided. Optionally, the second frame 421 and the side plate 13 of the housing 1 can be detachably connected or integrally connected, which is not limited herein.

[0077] In this embodiment, the second sampling needle 423 can be a reagent needle for aspirating the sample and adding it to the sample addition position of the detection module 3. The sample to be tested 15 can also be a non-punctured, open serum or plasma sample. The open serum or plasma sample without a cap is placed on the sampling table 121, and the sample is aspirated and added to the sample addition position of the detection module 3 by the three-dimensional sample and reagent needle.

[0078] It can be understood that the sampling table 121 is used to store the sampling tubes containing the samples to be tested 15. The sampling table 121 can be provided with a detachable sampling rack. The sampling rack is provided with one or more limiting holes or limiting grooves. At least part of the structure of each sampling tube is received and limited in the limiting hole or limiting groove to achieve reliable fixation of the sampling tube on the sample addition rack, and at the same time facilitate the automatic transfer of the empty sampling tubes outwards for waiting for sampling by mechanical devices such as robotic arms, or automatically placing the sampling tubes containing the blood samples into the limiting holes or limiting grooves of the sample addition rack, thereby improving the transfer efficiency of the sampling tubes on the sampling table 121.

[0079] During sampling, the sampling rack is disassembled from the sample injection table 121 and transferred to the sampling point. After sampling of each sampling tube is completed, the sampling tubes containing the collected blood samples are placed into the sampling rack, and then the sampling rack is transferred and fixed on the sample injection table 121 waiting for sample injection. During sample injection, the first sampling needle 413 / second sampling needle 423 of the transfer module 4 moves above the sample injection table 121, sucks the blood sample in a sampling tube, and then the first sampling needle 413 / second sampling needle 423 moves above the separation module 2 / detection module 3, and adds the blood sample into a separation cavity / sample loading position of the detection module 3. Repeating the above steps can add the blood samples in different sampling tubes into the sample loading positions of different separation cavities / detection modules 3, realizing automatic feeding of multiple blood samples and improving the sample loading efficiency of the sample analyzer 100.

[0080] In one embodiment, the housing 1 is further provided with a reagent inlet 132 communicating with the installation cavity 11. The reagent inlet 132 is adjacent to the second sampling assembly 42. The sample analyzer 100 further includes a reagent cartridge 5. The reagent cartridge 5 is connected to the housing 1 and is located at the reagent inlet 132. The reagent cartridge 5 is used for placing reaction reagents 53.

[0081] In this embodiment, as Figure 1 , Figure 3 , Figure 5 and Figure 6 shown, a reagent inlet 132 is provided on the right side plate of the side plate 13 of the housing 1. By providing the reagent cartridge 5, it is convenient for the reagent cartridge 5 to enter or exit the installation cavity 11 through the reagent inlet 132, so that the second sampling needle 423 of the second sampling assembly 42 can transfer the reaction reagent 53 in the reagent cartridge 5 to the detection module 3, so that the sample to be tested 15 / separated sample to be tested 15 reacts with the reaction reagent 53, facilitating the detection module 3 to perform detection.

[0082] In one embodiment, the reagent cartridge 5 includes a movable member 51 and a placement tray 52. The movable member 51 is movably connected to the housing 1 and is located at the reagent inlet 132. The placement tray 52 is detachably provided on the movable member 51. The placement tray 52 is used for placing reaction reagents 53. Among them, the movable member 51 drives the placement tray 52 to enter or exit the installation cavity 11 from the reagent inlet 132, so that the placement tray 52 is located on the movement path of the second sampling needle 423 between the sample injection table 121 and the detection module 3, and the second driving assembly 422 drives the second sampling needle 423 to reciprocate between the placement tray 52 and the detection module 3.

[0083] It can be understood that the reagent inlet 132 on the right side plate is adjacent to the base 12. The movable member 51 of the reagent bin 5 is movably connected to the base 12 of the housing 1. For example, the base 12 is provided with a slide rail, and the movable member 51 is slidably connected to the slide rail. Of course, in order to facilitate the automatic entry or exit of the installation cavity 11, the reagent bin 5 further includes a driving member provided on the base 12, and the output shaft of the driving member is connected to the movable member 51, so as to drive the movable member 51 to drive the placement tray 52 to enter or exit the installation cavity 11 from the reagent inlet 132.

[0084] In this embodiment, the placement tray 52 is provided with a groove structure for installing, fixing and limiting the reaction reagent 53. In order to facilitate the loading and replacement of the placement tray 52, the placement tray 52 is detachably provided on the movable member 51. For example, the placement tray 52 and the movable member 51 can be connected by detachable connection methods such as snap connection, plug-in fit, screw connection or pin connection.

[0085] It can be understood that in order to improve the aesthetics of the housing 1 and avoid contaminating the reaction reagent 53, the housing 1 further includes a door rotatably connected to the right side plate of the side plate 13, and the door can open or close the reagent inlet 132. The placement tray 52 can be selected as a plastic bracket for placing test tubes. As Figure 1 , Figure 3 , Figure 5 and Figure 6 shown, the reagent bin 5 has a position where the placement tray 52 is pushed into the installation cavity 11 from the reagent inlet 132 after being loaded and a position where the placement tray 52 is pulled out of the installation cavity 11 from the reagent inlet 132 after being used up, which are not limited here.

[0086] In one embodiment, the detection module 3 includes a rotation driving member 31, a rotating table 32, a detection module 33 and a cup feeding assembly 34. The rotation driving member 31 is provided in the installation cavity 11. The rotating table 32 is rotatably provided in the installation cavity 11 and is connected to the rotation driving member 31. The rotating table 32 is provided with a reaction station and a detection station. The detection module 33 is provided on one side of the rotating table 32. The cup feeding assembly 34 is provided in the installation cavity 11 and is arranged adjacent to the first sampling assembly 41. The cup feeding assembly 34 is provided with a cup placing cavity 341, a conveying channel 342 and a cup outlet 343. The two ends of the conveying channel 342 are respectively communicated with the cup placing cavity 341 and the cup outlet 343, and the cup outlet 343 is correspondingly arranged with the rotating table 32; wherein, the rotation driving member 31 drives the rotating table 32 to rotate, so that the detection station corresponds to the detection module 33, and the reaction station corresponds to the cup outlet 343.

[0087] In this embodiment, as Figures 3 to 6As shown, the detection module 33 includes a liquid path component, a cleaning tray, an incubation tray, a preheating component, a detector, an incubation and detection module, a mixing, cleaning and magnetic separation component, etc. The liquid path component includes various pumps, valves, pipelines, etc. of the liquid path system in the detection module 3. The cleaning tray is used to clean the magnetic beads and immune products in the reaction cup. The incubation tray is used for the reaction cup to hold the test sample 15 and react with the reaction reagent 53. The preheating component is used to heat or preheat the substrate reagent and add the heated substrate reagent into the reaction cup to avoid affecting the accuracy of the detection result due to temperature difference. The detector is a component used to perform photometric detection on the reacted sample reagent mixture. The incubation and detection module is a component used to add reagents, mix, clean, magnetically separate, add substrate, and perform photometric detection on the centrifuged plasma sample. The mixing, cleaning and magnetic separation component is a component used to separate the solid phase objects in the reacted mixture.

[0088] It can be understood that the reaction cup is a disposable container for holding the mixture of the test sample 15 and the reaction reagent 53 and performing photometric detection. After the detection is completed, the reaction cup will be discarded from the cup-throwing position. In this embodiment, the detection module 3 further has a cup-transferring gripper component, which is used to transfer the reaction cup between the two-circle trays of the incubation and detection module and the cup-throwing position, and also has a mixing function. Of course, the detection module 3 also has a cleaning position, which is used to clean the first sampling needle 413 / second sampling needle 423.

[0089] In this embodiment, the rotation driving member 31 and the rotating table 32 of the detection module 3 are installed on the base 12 of the machine housing 1 and are located on the side of the separation module 2 facing away from the sampling port 131. The rotating table 32 can be a carrier structure for holding or placing the reaction cup. The driving member 31 can be a driving motor or a rotating motor, etc. The rotation driving member 31 drives the rotating table 32 to rotate so that the detection station corresponds to the detection module 33 and the reaction station corresponds to the cup outlet 343. No limitation is made here.

[0090] It can be understood that the detection module 33 automatically detects the test sample separated by the separation module 2 through optical, electrochemical and other methods to obtain the physiological and pathological information of the corresponding subject, providing a basis for clinical diagnosis and treatment.

[0091] In this embodiment, as Figures 3 to 6As shown, by providing the cup feeding assembly 34, it is disposed on the left side plate of the side plate 13 of the housing 1 and adjacent to the first sampling assembly 41, thereby realizing a reasonable layout of the components within the installation cavity 11, improving the space utilization rate and reducing the volume of the housing 1. It can be understood that the cup feeding assembly 34 includes a storage box, a transmission member, and a cup separating member. The storage box of the cup feeding assembly 34 is provided with a cup placing cavity 341 for storing reaction cups. The transmission member is provided with a conveying channel 342 communicating with the cup placing cavity 341, such as a conveyor belt or a conveyor structure. The cup separating member is provided with a cup outlet 343 communicating with the conveying channel 342, so as to facilitate the reaction cups in the cup placing cavity 341 to be conveyed to the cup outlet 343 via the conveying channel 342, and the reaction cups at the cup outlet 343 are transferred to the reaction station via the cup transferring gripper assembly of the detection module 3, so that the first sampling needle 413 / second sampling needle 423 transfers the sample to be tested 15 / separated sample to be tested 15 and the reaction reagent 53 into the reaction cup for reaction. After the reaction is completed, the turntable 32 is driven to rotate by the driving member 31, so that the reaction cup is transferred from the reaction station to the detection station, and is detected by the detection module 33. After the detection is completed, the reaction cup is discarded from the cup discarding position via the cup transferring gripper assembly.

[0092] It can be understood that the cup feeding assembly 34 is used to send the reaction cups into the detection module 3 one by one, and the conveying channel 342 is used to send the reaction cups from the cup placing cavity 341 into the slideway of the incubation and detection module one by one.

[0093] In one embodiment, the housing 1 is further provided with a waste outlet 135 communicating with the installation cavity 11. The waste outlet 135 is adjacent to the replacement opening 133 and corresponds to the detection module 3. The sample analyzer 100 further includes a waste collection box 16. The waste collection box 16 is detachably disposed at the waste outlet 135 for collecting the waste after being detected by the detection module 3.

[0094] In this embodiment, as Figure 2 and Figure 4 shown, by providing the waste outlet 135 on the left side plate of the side plate 13 of the housing 1 and providing the waste collection box 16 at the waste outlet 135, the waste collection box 16 is used to collect the discarded or used reaction cups. It can be understood that the waste outlet 135 corresponds to the cup discarding position of the detection module 3.

[0095] For the convenience of recycling and timely cleaning, the waste collection box 16 is detachably disposed at the waste outlet 135. For example, the waste collection box 16 can be connected by means of snap connection, plug-in fit, screw connection, or pin connection. Of course, the waste collection box 16 can also be provided in a drawer structure at the waste outlet 135, which is not limited herein.

[0096] In one embodiment, the housing 1 is further provided with a replacement port 133 communicating with the installation cavity 11. The replacement port 133 corresponds to the separation module 2. The separation module 2 includes a third frame body, a separation driving member, and a separation disc 24. The third frame body is disposed in the installation cavity 11 and corresponds to the replacement port 133. The third frame body is provided with an installation groove 221. The separation driving member is disposed on a side of the third frame body facing away from the installation groove 221. The output shaft of the separation driving member penetrates the bottom wall of the installation groove 221. The separation disc 24 is movably disposed in the installation groove 221 and is detachably connected to the output shaft of the separation driving member. The separation disc 24 is provided with a separation cavity. Wherein, the separation driving member drives the separation disc 24 to rotate so as to separate the sample to be tested 15 in the separation cavity.

[0097] In this embodiment, as Figures 2 to 6 shown, the replacement port 133 is disposed on the left side plate of the side plate 13 of the housing 1. The third frame body of the separation module 2 is disposed on the base 12 of the housing 1 and is adjacent to the left side plate. The separation driving member and the separation disc 24 and other components are installed and fixed by using the third frame body. It can be understood that by providing the installation groove 221 in the third frame body, the separation disc 24 is limited and installed by using the installation groove 221. By providing the separation driving member, the output shaft of the separation driving member penetrates the bottom wall of the installation groove 221, so that it is convenient for the separation disc 24 placed in the installation groove 221 to be connected to the output shaft of the separation driving member. In this way, the separation driving member can be used to drive the separation disc 24 to rotate to achieve centrifugal separation.

[0098] It can be understood that, as Figures 2 to 6 shown, the separation disc 24 is provided with a sample addition position 241 and a sampling position 242 which are arranged at intervals. A separation cavity communicating with the sample addition position 241 and the sampling position 242 is further provided in the separation disc 24. In this embodiment, the first sampling needle 413 of the first sampling assembly 41 transfers the sample to be tested 15 from the sample injection table 121 to the sample addition position 241. The separation disc 24 is driven to rotate by the separation driving member to drive the blood sample in the separation cavity on the separation disc 24 to be centrifugally separated under the rotational centrifugal force, so that the blood sample added to the sample addition position 241 flows into the separation cavity, and the separation of blood cell components and plasma or serum components is realized in the separation cavity, obtaining the separated plasma or serum sample and the separated blood cell sample, and enabling the separated sample to be transferred from the sampling position 242 to the reaction cup of the detection module 3 by the second sampling needle 423 of the second sampling assembly 42.

[0099] Optionally, it is a better setting scheme that the separation disc 24 is horizontally arranged so as to rotate more smoothly and the centrifugal separation of the blood samples in each separation cavity is more consistent. The separation driving member includes but is not limited to a motor or a rotary cylinder.

[0100] It can be understood that the separation chamber is used to separate the plasma or serum component and the blood cell component in the blood sample. The separation chamber is arranged from the center of the separation disk 24 towards the outer edge of the separation disk 24. For example, when the separation disk 24 is a circular structure, the separation chamber is arranged along the radial direction of the separation disk 24; for another example, the blood sample separation chamber is arranged radially from the center of the separation disk 24 towards the outer edge of the separation carrier. This arrangement of the separation chamber can make full use of the rotational centrifugal force of the separation disk 24, enabling the plasma or serum component and the blood cell component in the blood sample in the separation chamber to achieve centrifugal separation in a shorter time, thereby improving the efficiency of blood sample separation. Among them, the separation chamber can be a channel structure or a cavity structure.

[0101] In this embodiment, as Figures 2 to 6 shown, the separation disk 24 is provided with a plurality of sample addition positions 241 and sampling positions 242. The plurality of sample addition positions 241 are arranged in a ring shape, the plurality of sampling positions 242 are arranged in a ring shape, and are located outside the plurality of sample addition positions 241, and the plurality of sample addition positions 241 and the plurality of sampling positions 242 are in one-to-one correspondence and communicated through a plurality of separation chambers.

[0102] It can be understood that the blood sample is added into the separation chamber through the sample addition position 241, and the separation driving member drives the separation disk 24 to rotate. Under the action of the rotational centrifugal force, the blood cell component with a greater density is subjected to a greater centrifugal force than the plasma or serum component. After the blood cell component is separated from the plasma or serum component, the blood cell component displaces the plasma or serum component, causing the plasma or serum component to remain in the local space of the separation chamber close to the sample addition position 241, and the separated blood cell component remains in the local space of the separation chamber far from the sample addition position 241. The plasma or serum component and the blood cell component are accommodated in different local spaces of the separation chamber, realizing the separation of the plasma or serum component and the blood cell component in the blood sample. After the above separation procedure, the second sampling assembly 42 extracts the plasma or serum sample in the separation chamber through the sampling position 242, thereby realizing the automated sample addition, separation, and sampling processing of the blood sample through the above process, and improving the efficiency of blood sample processing.

[0103] The sample analyzer 100 can accommodate plasma or serum components and blood cell components in different local spaces of the separation chamber, realizing the separation of plasma or serum components and blood cell components in the blood sample. The separation disc 24 can accommodate the separated plasma or serum sample and blood cell sample in different cavity spaces in the separation chamber. The plasma or serum sample and the blood cell sample are accommodated in separate spaces. Through the sampling position 242, the plasma or serum sample in the separation chamber can be extracted without easily misextracting the blood cell sample, which can ensure the purity of the extracted plasma or serum sample and reduce the precision requirements of the sampling operation. At the same time, a small amount of blood sample can also achieve the above-mentioned process of separating and accommodating blood cell components and plasma or serum components in separate spaces through the separation module 2, without the need to collect a large amount of blood samples, which can reduce the detection amount of blood samples and has a good separation effect.

[0104] In one embodiment, the third frame body includes a mounting frame 21 and a separation seat 22. The mounting frame 21 is arranged in the mounting cavity 11 and is correspondingly arranged opposite to the replacement port 133. The mounting frame 21 is provided with a sliding rail 211. The separation seat 22 is slidably connected to the sliding rail 211. The separation seat 22 is provided with a mounting groove 221. The separation driving member is arranged on the side of the separation seat 22 facing away from the mounting groove 221. The separation module 2 further includes a replacement driving member. The replacement driving member is arranged on the mounting frame 21 and is connected to the separation seat 22. The replacement driving member drives the separation seat 22 to drive the separation disc 24 to enter or exit the mounting cavity 11 from the replacement port 133.

[0105] In this embodiment, as Figures 2 to 6 shown, by setting the third frame body as the mounting frame 21 and the separation seat 22, the mounting frame 21 is arranged on the base 12 of the machine shell 1 and is adjacent to the left side plate. The mounting frame 21 is used to install and fix components such as the separation seat 22, the separation driving member, and the separation disc 24.

[0106] It can be understood that by providing the mounting groove 221 on the separation seat 22, the separation disc 24 can be limited and installed by using the mounting groove 221. By arranging the separation driving member on the side of the separation seat 22 facing away from the mounting groove 221, the output shaft of the separation driving member penetrates the bottom wall of the mounting groove 221, so as to facilitate the connection between the separation disc 24 placed in the mounting groove 221 and the output shaft of the separation driving member. In this way, the separation driving member can be used to drive the separation disc 24 to rotate to achieve centrifugal separation.

[0107] In this embodiment, as Figures 2 to 6 shown, by providing the sliding rail 211 and the replacement driving member on the mounting frame 21, the separation seat 22 is slidably connected to the sliding rail 211, so that the replacement driving member drives the separation seat 22 to drive the separation disc 24 to enter or exit the mounting cavity 11 from the replacement port 133, facilitating the replacement of the separation disc 24.

[0108] In one embodiment, the housing 1 is further provided with a movable baffle 134 corresponding to the replacement opening 133. The movable baffle 134 is movably connected to the housing 1 to open or close the replacement opening 133. It can be understood that with such a setting, after the separation disc 24 is replaced, the replacement driving member is used to drive the separation seat 22 to drive the separation disc 24 to enter the installation cavity 11 from the replacement opening 133, and the movable baffle 134 is used to cover the replacement opening 133 to ensure the tightness of the installation cavity 11, thereby ensuring that the sample is not contaminated.

[0109] It can be understood that the movable baffle 134 is rotatably connected to the base 12 of the housing 1, for example, by means of hinge connection, hole-shaft connection or other rotational connection methods, which are not limited herein.

[0110] Of course, the replacement opening 133 includes two openings arranged at intervals. One opening of the replacement opening 133 corresponds to the separation disc 24. At this time, the separation disc 24 has a structure with a self-contained door, a structure that can be automatically ejected horizontally like a drawer. The other opening of the replacement opening 133 is located below the opening corresponding to the separation disc 24. At this time, the movable baffle 134 is arranged corresponding to this opening to facilitate opening and replacing the substrate reagent, which is not limited herein.

[0111] In one embodiment, the housing 1 is further provided with a placement rack adjacent to the replacement opening 133. The placement rack is provided with a placement cavity for placing the separation disc 24. It can be understood that with such a setting, it is convenient for the user to directly install the new separation disc 24 to be replaced from the placement rack into the installation groove 221 of the separation seat 22, improving convenience.

[0112] In one embodiment, the test sample 15 is provided with an identification code. The sample analyzer 100 further includes a detection member 6. The detection member 6 is arranged on the housing 1 and corresponds to the sampling table 121. The detection member 6 is used to detect the identification code of the test sample 15.

[0113] In this embodiment, as Figures 1 to 6 shown, by setting an identification code on the test sample 15, the test tube containing the test sample 15 can be distinguished as a capped test tube or an uncapped test tube by using the identification code, so as to facilitate distinguishing the types of the test samples 15, so that the sample analyzer 100 can perform tests according to different samples. It can be understood that the detection member 6 can be a barcode scanner for scanning the identification code or barcode pasted on the test tube.

[0114] It can be understood that when the biochemical analyzer 100 is running, the controller 81 first controls the detection component 6 to detect the identification code on the sample to be tested 15. After the detection is completed, the first sampling component 41 / the second sampling component 42 samples according to the different detected identification codes. In this embodiment, the detection component 6 can be arranged on the left or right side of the first sampling component 41 and the second sampling component 42. Of course, in other embodiments, the first sampling component 41 and the second sampling component 42 can also be located on opposite sides of the detection component 6. At this time, the first sampling component 41 and the second sampling component 42 still sample according to different identification codes after the detection component 6 detects the identification code on the sample to be tested 15.

[0115] In one embodiment, the sample loading platform 121 is provided with a puncture position and a sampling position. The puncture position is arranged corresponding to the first sampling component 41, and the sampling position is arranged corresponding to the second sampling component 42.

[0116] In this embodiment, the sample loading platform 121 is provided with multiple different areas. For example, the sample loading platform 121 is provided with a puncture position corresponding to the first sampling component 41, and the sample loading platform 121 is provided with a sampling position corresponding to the second sampling component 42. It can be understood that the detection component 6 can detect according to the test tube type of the sample to be tested 15 to distinguish whether the test tube containing the sample to be tested 15 is a capped test tube or an uncapped test tube.

[0117] It can be understood that a driving mechanism for driving the transfer of the sample to be tested 15 is arranged in the sample loading platform 121. When the detection component 6 detects that the test tube of the sample to be tested 15 is a capped test tube, the driving mechanism transfers the sample to be tested 15 to the puncture position for sampling or transfer by the first sampling component 41. When the detection component 6 detects that the test tube of the sample to be tested 15 is an uncapped test tube, the driving mechanism transfers the sample to be tested 15 to the sampling position for sampling or transfer by the second sampling component 42.

[0118] Optionally, the driving mechanism can be a conveyor belt, a conveying mechanism or other structures capable of realizing the transfer of the sample to be tested 15, which is not limited herein. Optionally, the sample loading platform 121 is provided with a sampler, which is a mechanism for realizing the cyclic sampling of the sample to be tested 15, which is not limited herein.

[0119] In one embodiment, the sample loading platform 121 is further provided with a cyclic sampling channel, and the cyclic sampling channel extends from the sampling position to the puncture position. It can be understood that by arranging the cyclic sampling channel on the sample loading platform 121, the transfer and cycle of different samples to be tested 15 can be realized by using the cyclic sampling channel. In this embodiment, the driving mechanism in the sample loading platform 121 transfers the sample to be tested 15 in a capped test tube from the sampling position to the puncture position via the cyclic sampling channel.

[0120] In one embodiment, the sampling table 121 is further provided with an emergency position, which is arranged adjacent to the puncture position. It can be understood that by setting the emergency position, the emergency position can be used to insert and detect the sample to be tested 15, so as to perform sample detection as soon as possible.

[0121] In this embodiment, corresponding to the puncture position, the sample suction position and the emergency position on the sampling table 121, there are respectively provided structures such as placement racks or test tube racks for placing or fixing the sample to be tested 15, which are not limited herein.

[0122] In one embodiment, the sample analyzer 100 further includes a mixing assembly 7, which includes a fixed frame 71, a mixing driving member 72 and a mixing jaw 73. The fixed frame 71 is arranged in the installation cavity 11 and is adjacent to the sample inlet 131. The mixing driving member 72 is arranged on the fixed frame 71. The mixing jaw 73 is connected to the output shaft of the mixing driving member 72, and the mixing jaw 73 is provided with a clamping groove 74. Among them, the mixing driving member 72 drives the mixing jaw 73 to clamp the sample to be tested 15 in the clamping groove 74 for mixing.

[0123] In this embodiment, by setting the mixing assembly 7, the mixing assembly 7 can be used to mix the sample to be tested 15 on the sampling table 121 to improve the detection accuracy. It can be understood that the mixing driving member 72 can be a driving motor, a rotating motor or a rotating cylinder and other structures, which are not limited herein. Optionally, the mixing jaw 73 can be a jaw cylinder or a mechanical claw and other structures, which are not limited herein.

[0124] In one embodiment, the sample analyzer 100 further includes a controller 81 and a display screen 82 arranged on the machine shell 1. The display screen 82 is arranged adjacent to the sample inlet 131. The controller 81 is electrically connected to the display screen 82, the separation module 2, the detection module 3 and the transfer module 4.

[0125] In this embodiment, as Figures 1 to 4 shown, the controller 81 can be a control center or a circuit board or a control board integrated with a control program and other structures. The controller 81 is electrically connected to the display screen 82, the separation module 2, the detection module 3 and the transfer module 4 through wired or wireless communication means.

[0126] It can be understood that the controller 81 is electrically connected or signal-connected to the display screen 82, the separation driving member and the replacement driving member of the separation module 2, the rotation driving member and the detection module 33 of the detection module 3 and the sample cup feeding assembly, and the first sampling assembly 41 and the second sampling assembly 42 of the transfer module 4. The display screen 82 is used to display the start and end information of the separation module 2, the detection information of the detection module 3, the sample addition information of the transfer module 4, etc., which are not limited herein.

[0127] In this embodiment, the side plate 13 further includes a front side plate, which is rotatably connected to the left side plate or the right side plate. The front side plate is provided with a sampling port 131. The biochemical analyzer 100 further includes a display screen 82 disposed on the side of the front side plate facing away from the installation cavity 11. The display screen 82 is spaced apart from the sampling port 131 and is electrically connected to the controller 81. The display screen 82 is electrically connected to the separation module 2, the detection module 3, and the transfer module 4. It can be understood that the front side plate is rotatably connected to the left side plate or the right side plate so that the display screen 82 disposed on the front side plate can be rotated and opened along with the front side plate, which is convenient for maintenance.

[0128] The working principle of the sample analyzer 100 is as follows:

[0129] 1. The user places the test tube containing the whole blood sample and the test tube rack on the sampling table 121. When the sampling table 121 does not perform cyclic sampling, it can load 5 rows of test tube racks and 25 test tubes; when performing cyclic sampling, it can load 10 rows of 50 samples. The sampling table 121 sends the test tubes to the corresponding test tube presence / absence detection positions of the detection member 6 one by one. The detection member 6 detects the presence / absence of the test tubes, and the scanning position of the detection member 6 scans the barcodes of the test tubes. The mixing assembly 7 lifts and mixes the test tubes at the mixing position and then moves them to the puncture position. The first sampling needle 413 of the first sampling assembly 41 pierces the test tube cap with the two-dimensional needle after puncturing the test tube cap and aspirates the whole blood sample and moves it to the sample loading position 241 of the separation disk 24 of the separation module 2 and enters the separation cavity.

[0130] 2. After the puncture sample needle of the first sampling needle 413 injects the whole blood sample into the separation disk 24, the separation driving member drives the separation disk 24 to rotate at high speed for centrifugation. The second sampling needle 423 of the second sampling assembly 42 on the right side, the three-dimensional reagent sample needle, injects the centrifuged plasma sample into the sample loading and reagent adding hole position, and below this hole position is the reaction cup pushed out by the cup feeding assembly 34.

[0131] 3. It should be noted that when the test tube presence / absence detection position detects that the test tube is without a cap and is an open non-whole blood sample, such as a plasma or serum sample, the above-mentioned sample aspiration process can be changed to non-mixing and non-puncturing sample aspiration. At the non-puncturing and open cap serum / plasma sample aspiration position, that is, the second sampling needle 423 of the second sampling assembly 42, the three-dimensional reagent sample needle, directly aspirates the serum / plasma sample and adds it to the sample loading and reagent adding hole position of the incubation and detection module.

[0132] 4. The three-dimensional reagent sample needle of the second sampling needle 423 aspirates various reaction reagents 53 from the reagent storage 5 and adds them to the reaction cup; the cup transfer gripper assembly of the detection module 3 rotates and transfers the reaction cup to each incubation, cleaning, magnetic separation, and substrate injection hole position; after the reaction is completed and the photometry is performed, the reaction cup is moved out to the cup discarding position for cup discarding to complete the detection.

[0133] The above 1 and 2 are the sample loading processes for whole blood samples; 3 is the sample loading process for non-whole blood samples such as serum and plasma. The sample analyzer 100 is a model that can support samples such as whole blood, serum, and plasma simultaneously.

[0134] It can be understood that in some embodiments of the present application, the sample analyzer 100 can be a non-whole blood sample analyzer that only supports the detection of serum and plasma and does not have the functions of mixing and whole blood puncture sampling; in other embodiments, the sample analyzer 100 can be a whole blood sample analyzer that supports whole blood detection and has the functions of mixing and puncture sampling. Through in-machine mixing and centrifugation, the operation of the user centrifuging the whole blood sample is saved, labor is saved, and cumbersome operations are avoided; at the same time, the biosafety risk of opening the lid outside the machine can be avoided; the waiting and transfer time from the centrifuge to the instrument can be shortened, and the result output speed of emergency samples can be improved; the transfer of samples on the centrifuge in sequence can be reduced, and the risk of sample confusion can be reduced; and the left and right dimensions of the whole machine are greatly reduced compared to other instruments, saving space and reducing weight; at the same time, the vibration and noise of the centrifuge can be avoided.

[0135] The above are only optional embodiments of the present invention, and do not limit the patent scope of the present invention. All equivalent structural transformations made under the concept of the present invention using the content of the specification and drawings of the present invention, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present invention.

Claims

1. A sample analyzer, characterized in that, The sample analyzer comprises: A housing, wherein the housing is provided with an installation cavity and an injection port connected to the installation cavity, the housing is further provided with an injection platform corresponding to the injection port, the injection platform is used to place a sample to be tested, and the housing is further provided with a replacement port connected to the installation cavity; A separation module, the separation module is arranged in the installation cavity and corresponds to the replacement port, the separation module is provided with a separation cavity, the separation cavity is used to accommodate the sample to be tested, and the separation module is used to separate the sample to be tested; A detection module, the detection module is arranged in the installation cavity and located at a side of the separation module away from the injection port, the detection module is used to detect the sample to be tested; and A transfer module, the transfer module is arranged in the installation cavity, and the transfer module is used to transfer the sample to be tested on the injection station to the separation cavity or the detection module; In which, the separation module includes a third frame, a separation drive, a separation disc and a replacement drive, the third frame is arranged in the mounting cavity and corresponds to the replacement port, the third frame is provided with a mounting slot, the separation drive is arranged on a side of the third frame facing away from the mounting slot, the output shaft of the separation drive passes through the bottom wall of the mounting slot, the separation disc is movably arranged in the mounting slot and is detachably connected to the output shaft of the separation drive, and the separation disc is provided with the separation cavity; the third frame includes a mounting frame and a separation seat, the mounting frame is arranged in the mounting cavity and corresponds to the replacement port, the mounting frame is provided with a sliding rail, the separation seat is slidably connected to the sliding rail, the separation seat is provided with the mounting slot, the separation drive is arranged on a side of the separation seat facing away from the mounting slot, the replacement drive is arranged on the mounting frame and connected to the separation seat, the replacement drive drives the separation seat to drive the separation disc to enter or exit the mounting cavity, and the separation drive drives the separation disc to rotate so that the sample to be tested in the separation cavity is separated.

2. The sample analyzer according to claim 1, characterized in that, The transfer module comprises: A first sampling assembly, which is disposed in the installation cavity and opposite to the separation module, and includes a first frame disposed in the housing, a first driving assembly and a first sampling needle, wherein the first driving assembly is connected to the first frame, and the first sampling needle is connected to the first driving assembly, and the first driving assembly is used to drive the first sampling needle to reciprocate between the injection station and the separation cavity to absorb and transfer the sample to be tested; and A second sampling component, the second sampling component is arranged in the installation cavity, the second sampling component is opposite to the first sampling component and is arranged at a distance, the second sampling component includes a second frame provided in the housing, a second driving component and a second sampling needle, the second driving component is connected to the second frame, the second sampling needle is connected to the second driving component, and the second driving component is used to drive the second sampling needle to reciprocate between the injection station or the separation cavity and the detection module to absorb and transfer the separated sample to be tested.

3. The sample analyzer according to claim 2, characterized in that, The housing is further provided with a reagent inlet communicating with the installation cavity, the reagent inlet is arranged adjacent to the second sampling assembly, the sample analyzer further includes a reagent chamber, the reagent chamber is connected to the housing and is located at the reagent inlet, and the reagent chamber is used for placing reaction reagents.

4. The sample analyzer according to claim 3, characterized in that, The reagent chamber includes: a movable member, the movable member is movably connected to the housing and is located at the reagent inlet; and a placement tray, the placement tray is detachably arranged on the movable member, and the placement tray is used for placing reaction reagents; wherein, the movable member drives the placement tray to enter or exit the installation cavity from the reagent inlet, so that the placement tray is located on the movement path of the second sampling needle between the sample injection table and the detection module, and the second driving assembly drives the second sampling needle to reciprocate between the placement tray and the detection module.

5. The sample analyzer according to claim 2, wherein The detection module includes: a rotation driving member, the rotation driving member is arranged in the installation cavity; a rotating table, the rotating table is rotatably arranged in the installation cavity and is connected to the rotation driving member, and the rotating table is provided with a reaction station and a detection station; a detection module, the detection module is arranged on one side of the rotating table; a cup feeding assembly, the cup feeding assembly is arranged in the installation cavity and is adjacent to the first sampling assembly, the cup feeding assembly is provided with a cup placement cavity, a conveying channel and a cup outlet, both ends of the conveying channel are communicated with the cup placement cavity and the cup outlet respectively, and the cup outlet is arranged corresponding to the rotating table; wherein, the rotation driving member drives the rotating table to rotate, so that the detection station corresponds to the detection module, and the reaction station corresponds to the cup outlet.

6. The sample analyzer according to claim 1, wherein, The housing is further provided with a movable baffle corresponding to the replacement opening, the movable baffle is movably connected to the housing to open or close the replacement opening; and / or, the housing is further provided with a placement rack adjacent to the replacement opening, and the placement rack is provided with a placement cavity for placing the separation disc; and / or, the housing is further provided with a waste outlet communicating with the installation cavity, the waste outlet is arranged adjacent to the replacement opening and corresponds to the detection module, the sample analyzer further includes a waste collection box, and the waste collection box is detachably arranged at the waste outlet for collecting the waste after being detected by the detection module.

7. The sample analyzer according to claim 2, wherein The test sample is provided with an identification code, the sample analyzer further includes a detection member, the detection member is arranged on the housing and corresponds to the sample injection table, and the detection member is used for detecting the identification code of the test sample.

8. The sample analyzer according to claim 7, wherein, The sample injection table is provided with a puncture position and a sampling position, the puncture position corresponds to the first sampling assembly, and the sampling position corresponds to the second sampling assembly.

9. The sample analyzer according to claim 8, characterized in that, The sample injection table is further provided with a circulating sample injection channel, and the circulating sample injection channel extends from the sampling position to the puncture position; and / or, the sample injection table is further provided with an emergency position, and the emergency position is arranged adjacent to the puncture position.

10. The sample analyzer according to any one of claims 1 to 9, characterized in that, The sample analyzer further includes a mixing assembly, and the mixing assembly includes: a fixed rack, the fixed rack is arranged in the installation cavity and is adjacent to the sample injection port; a mixing driving member, the mixing driving member is arranged on the fixed rack; and The mixing gripper, the mixing gripper is connected to the output shaft of the mixing driving member, and the mixing gripper is provided with a clamping groove; Wherein, the mixing driving member drives the mixing gripper to clamp the sample to be tested in the clamping groove for mixing.

11. The sample analyzer according to any one of claims 1 to 9, characterized in that, The sample analyzer further includes a controller and a display screen provided on the housing, the display screen is disposed adjacent to the sample inlet, and the controller is electrically connected to the display screen, the separation module, the detection module and the transfer module.

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