Film viewing equipment and methods

Abstract

This application discloses a slide reading device and a slide reading method. The slide reading device includes: a sample feeding device for feeding a sample slide to be tested; a slide transfer device for picking up a target slide from the sample slide and transferring the target slide to an operating position, the operating position including an oil-dropping position and a microscopic examination position; an oil-dropping device corresponding to the oil-dropping position and used to perform an oil-dropping operation on the target slide located at the oil-dropping position; and a microscopic examination device for performing a microscopic examination operation on the target slide located at the microscopic examination position. The slide reading device provided in this application performs a preset oil-dropping operation on the target slide transferred to the oil-dropping position through the oil-dropping device corresponding to the oil-dropping position, which solves the problems of the complex structure and large volume of existing slide reading devices, as well as the problems of the lengthy slide reading process and the long processing time.

Description

Technical Field

[0001] This application relates to the field of medical devices, and more particularly to a film reading device and a film reading method. Background Technology

[0002] Currently, people often prepare sample slides from cell samples to be tested and use the microscopic examination device of the slide reading equipment to perform microscopic examination and analysis on the sample slides to obtain the corresponding test results.

[0003] In the inspection of some sample slides, immersion oil needs to be applied to the surface of the target slide before microscopic examination to improve the image quality acquired during the examination. Therefore, most existing slide reading equipment is equipped with an oil-applying device and a corresponding device to drive the oil-applying device. The corresponding device must first drive the oil-applying device to a suitable position, and then control the oil-applying device in the suitable position to apply immersion oil to the target slide. Then, the target slide covered with immersion oil is examined under a microscope. This results in a complex structure and large volume of existing slide reading equipment, as well as a lengthy and time-consuming slide reading process. Summary of the Invention

[0004] This application provides a film reading device and a film reading method, which aims to solve the problems of the complex structure and large volume of existing film reading devices, as well as the lengthy film reading process and the time-consuming procedures.

[0005] In a first aspect, this application provides a film viewing device, comprising:

[0006] The sample introduction device is used to feed the sample slide to be tested;

[0007] A slide transfer device is used to pick up a target slide from a sample slide and transfer the target slide to an operating position, which includes an oil-dropping position and a microscopic examination position.

[0008] An oil-drip device is provided, which is set up for the oil-drip position and is used to perform an oil-drip operation on the target glass slide located at the oil-drip position;

[0009] Microscopic examination device, used to perform microscopic examination on a target slide located in the microscopic examination position.

[0010] Optionally, the transfer device includes a clamping module for holding the target slide from the sample slide and a drive module for driving the clamping module to move.

[0011] In this device, the target glass slide is clamped in the clamping module during the oil-drip operation; and / or

[0012] When performing microscopic examination, the clamping mechanism of the microscopic examination device is clamped to the clamping module.

[0013] Optionally, the clamping module includes:

[0014] The clamping mechanism includes a first clamping component and a second clamping component, which are movably connected and cooperate to form a clamping opening for clamping a target glass slide.

[0015] Optionally, the clamping module further includes an elastic component and a first driving component. The elastic component is connected to at least one of the first clamping component and the second clamping component to form an elastic clamping engagement between the first clamping component and the second clamping component. The first driving component is at least used to drive the second clamping component to overcome the elastic resistance of the elastic component and displace relative to the first clamping component to the side away from the first clamping component to form a clamping opening. When the driving component stops driving the second clamping component, the second clamping component is displaced towards the side closer to the first clamping component under the action of the elastic component to close the clamping opening.

[0016] Optionally, the first clamping assembly includes a first clamping arm and a first clamping member connected to the first clamping arm and at least partially exposed in the first clamping arm; the second clamping assembly includes a second clamping arm movably connected to the first clamping arm and a second clamping member connected to the second clamping arm and at least partially exposed in the second clamping arm.

[0017] Wherein, the thickness of the first clamping member and the second clamping member in the first direction is less than the thickness of the first clamping arm and the second clamping arm in the first direction, and the first direction is the displacement direction of the second clamping component relative to the first clamping component under the action of the elastic component.

[0018] Optionally, the clamping mechanism further includes an elastic clamping member disposed on the side of the first clamping arm facing the second clamping arm or the side of the second clamping arm facing the first clamping arm.

[0019] Optionally, the transfer device includes:

[0020] The second clamping module is used to clamp the target glass slide from the sample glass slide and transport the target glass slide to the preset transfer position;

[0021] The transport module is used to carry the target glass slide from the second clamping module to the transfer position and transport the target glass slide to the preset operation position.

[0022] Optionally, the sample introduction device includes:

[0023] A feeding mechanism for feeding a slide basket loaded with sample slides;

[0024] A flipping mechanism is used to receive the slide basket from the self-feeding mechanism and flip the slide basket at a preset angle.

[0025] Optionally, the flipping mechanism includes the following when flipping the slide basket by a preset angle:

[0026] This causes the glass slide basket to rotate at the highest speed;

[0027] When the glass slide basket reaches the preset first angle, it is driven to rotate to the preset angle at a second speed, wherein the second speed is less than the first speed.

[0028] Optionally, the microscopic examination position and the oil drop position are set at intervals, and the horizontal distance between the microscopic examination position and the oil drop position is greater than the width of the target slide.

[0029] Optionally, the slide reading device also includes an immersion oil recovery device, which is used at least to recover the immersion oil that overflows from the surface of the target slide when it is at the dripping point.

[0030] Secondly, this application also provides a method for viewing films, including:

[0031] Feed the sample slide to be tested;

[0032] Pick up the target slide from the sample slide and transfer the target slide to the oil-dropping position, where an oil-dropping device is provided.

[0033] The oil-drip device is controlled to perform an oil-drip operation on the target glass slide located at the oil-drip position;

[0034] Transfer the target glass slide to the oil dripping point;

[0035] Perform microscopic examination on the target slide located in the microscopic examination position.

[0036] This application provides a slide reading device and method. The slide reading device includes: a sample feeding device for feeding a sample slide to be tested; a slide transfer device for picking up a target slide from the sample slide and transferring the target slide to an operating position, the operating position including an oil-dropping position and a microscopic examination position; an oil-dropping device corresponding to the oil-dropping position and used to perform an oil-dropping operation on the target slide located at the oil-dropping position; and a microscopic examination device for performing a microscopic examination operation on the target slide located at the microscopic examination position. The slide reading device and method provided in this application solve the problems of complex structure and large volume of existing slide reading devices, as well as the problems of lengthy reading processes and time-consuming procedures, by using an oil-dropping device corresponding to the oil-dropping position to perform a preset oil-dropping operation on the target slide transferred to the oil-dropping position.

[0037] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit the disclosure of the embodiments of this application. Attached Figure Description

[0038] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0039] Figure 1 A block diagram of a module structure of a film reading device provided in an embodiment of this application;

[0040] Figure 2 A schematic diagram of the slide transfer device, oil dripping device, and microscopic examination device of a slide reading device provided in an embodiment of this application;

[0041] Figure 3 This is a schematic diagram of the structure of a sample feeding device for a film reading device provided in an embodiment of this application;

[0042] Figure 4 This is a schematic diagram of the structure of a slide transfer device in a slide reading device provided in an embodiment of this application;

[0043] Figure 5 This is an exploded view of the clamping module of a slide transfer device in a slide reading apparatus provided in an embodiment of this application.

[0044] Figure 6 A schematic diagram illustrating the cooperation between the slide transfer device and the flipping mechanism of the slide reading device provided in the embodiments of this application;

[0045] Figure 7 This is a schematic diagram of the flipping mechanism of the film reading device provided in the embodiments of this application;

[0046] Figure 8 This is a schematic diagram of the immersion oil recovery device for the film reading equipment provided in the embodiments of this application;

[0047] Figure 9 This is a schematic flowchart of the image reading method provided in the embodiments of this application;

[0048] Figure label:

[0049] 100. Film viewing equipment; 10. Sample injection device; 11. Feeding mechanism;

[0050] 12. Tilting mechanism; 121. Receiving assembly; 1211. Receiving cavity;

[0051] 1212, Accommodation opening; 122, Rotating assembly; 1221, Motor output end;

[0052] 1212, Connecting plate; 1213, First clamping plate; 1214, Second clamping plate;

[0053] 123. Optical sensor; 20. Slide transfer device; 21. Clamping module;

[0054] 211. Clamping mechanism; 212. Elastic component; 213. Drive component;

[0055] 2111, First clamping assembly; 2112, Second clamping assembly; 2113, First clamping arm;

[0056] 2114. Second clamping arm; 2115. First clamping component; 2116. Second clamping component;

[0057] 214. Elastic clamping component; 22. Drive module; 30. Oil dripping device;

[0058] 40. Microscopic examination device; 41. Image acquisition assembly; 42. Light source assembly;

[0059] 50. Mirror oil recovery device; 51. Mirror oil recovery component; 52. Mirror oil recovery tank;

[0060] 53. Recycling tank opening; 200. Sample slide; 201. Target slide;

[0061] 300. Slide basket; 301. Opening. Detailed Implementation

[0062] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0063] The following detailed description of some embodiments of this application is provided in conjunction with the accompanying drawings. Unless otherwise specified, the following embodiments and features can be combined with each other.

[0064] Currently, microscopic examination of sample slides made from cell samples using slide reading equipment can obtain test results corresponding to the cell samples and the corresponding human health status. However, for some sample slides, immersion oil needs to be applied to the surface of the target slide before microscopic examination to improve the quality of the examination. Therefore, existing slide reading equipment often needs to first drive the oil-applying device to a suitable position, then control the oil-applying device in the appropriate position to apply immersion oil to the sample slide, and then perform microscopic examination on the target slide covered with immersion oil. This results in a complex structure and large volume of existing slide reading equipment, as well as a lengthy and time-consuming reading process.

[0065] Based on this, this application provides a film reading device, which aims to solve the problems that the existing film reading devices have a relatively complex structure, occupy a large volume, and have a lengthy film reading process and consume a lot of time.

[0066] Please see Figures 1-3 , Figure 1 This is a block diagram of a module structure of a film reading device provided in an embodiment of this application. Figure 2 This is a schematic diagram of the structure of a slide transfer device, an oil dispensing device, and a microscopic examination device for a slide reading equipment provided in an embodiment of this application. Figure 3 This is a schematic diagram of the sample feeding device and slide transfer device of a slide reading device provided in an embodiment of this application.

[0067] like Figures 1-3 As shown, the slide reading device 100 provided in this embodiment is used to perform preset slide reading operations on a target slide 201. The slide reading device 100 includes a sample feeding device 10, a slide transfer device 20, an oil dispensing device 30, and a microscopic inspection device 40. The sample feeding device 10 is used to feed at least one sample slide 200 to be tested. The slide transfer device 20 is used to pick up the target slide 201 from at least one sample slide 200 and transfer the target slide 201 to a preset operation position. The operation position includes at least an oil dispensing position and a microscopic inspection position. The oil dispensing device 30 is set corresponding to the oil dispensing position and is used to perform a preset oil dispensing operation on the target slide 201 located at the oil dispensing position so that the surface of the target slide 201 is at least partially covered with immersion oil. The microscopic inspection device 40 is used to perform a preset microscopic inspection operation on the target slide 201 located at the microscopic inspection position and covered with immersion oil.

[0068] It should be understood that the sample slide 200 includes the target slide 201, which is at least one of several sample slides 200. The target slide 201 is generally stored together with the other sample slides 200, for example, the target slide 201 and other sample slides 200 are stored alternately in a preset slide basket 300. The following describes the operation of each component of the slide reading device 100 when performing a preset slide reading operation on the target slide 201, taking the example of the target slide 201 and other sample slides 200 being stored in the slide basket 300.

[0069] Specifically, when the slide reading device 100 performs a slide reading operation on the target slide 201, it first controls the sample feeding device 10 to obtain the slide basket 300 containing the sample slide 200, controls the slide transfer device 20 to pick up the target slide 201 from the sample slide 200 in the slide basket 300, and transfers the target slide 201 to the oil-dropping position. Then, it controls the oil-dropping device 30 to perform an oil-dropping operation on the target slide 201 so that the surface of the target slide 201 is at least partially covered with immersion oil. Then, when the slide transfer device 20 transfers the target slide 201 to the microscopic inspection position, it controls the microscopic inspection device 40 to perform a microscopic inspection operation on the target slide 201.

[0070] The slide reading device 100 provided in this embodiment is equipped with an oil-drip device 30 at the corresponding oil-drip position, and the target slide 201 is transferred to the oil-drip position for oil dripping, which shortens the slide reading process and reduces the time consumed in the process. At the same time, it also simplifies the structure of the slide reading device 100 and reduces the space occupied.

[0071] Furthermore, the microscopic examination device 40 can be set up corresponding to the microscopic examination position. After the target slide 201 is transferred to the microscopic examination position, the microscopic examination device 40 is controlled to perform microscopic examination on the target slide 201 located at the microscopic examination position. By setting up the microscopic examination device 40 corresponding to the microscopic examination position and transferring the target slide 201 to the microscopic examination position for microscopic examination, the slide reading process is shortened and the process time is reduced. At the same time, the structure of the slide reading equipment 100 is simplified and the space occupied is reduced.

[0072] In some embodiments, the microscopic examination position and the oil drop position are spaced apart, and the horizontal distance between the microscopic examination position and the oil drop position is greater than the width of the target slide 201.

[0073] It should be understood that some slide reading operations may not require the addition of immersion oil, such as some low-magnification slide reading operations. In these cases, it is not necessary to add immersion oil to the target slide 201. The slide transfer device 20 can be directly controlled to transfer the target slide 201 to the examination position, and the examination device 40 can be controlled to perform the examination operation on the target slide 201. However, the oil-dispensing device 30 has an oil outlet. Due to the surface tension of the liquid, a small portion of the immersion oil dispensed by the oil-dispensing device 30 may remain suspended at the oil outlet. Therefore, during the process of controlling the slide transfer device 20 to transfer the target slide 201 to the examination position, or during the process of controlling the examination device 40 to perform the examination operation on the target slide 201 located at the examination position, the oil suspended at the oil outlet may drip onto the target slide 201, causing contamination and affecting the examination results.

[0074] Based on this, the microscopic examination position and the oil dripping position in the slide reading device 100 are set at intervals, and the horizontal distance between the microscopic examination position and the oil dripping position is greater than the width of the target slide 201. During the process of controlling the slide transfer device 20 to transfer the target slide 201 to the microscopic examination position, the slide transfer device 20 can be used to control the target slide 201 to bypass the oil dripping position. During the process of controlling the microscopic examination device 40 to perform microscopic examination on the target slide 201 located at the microscopic examination position, the distance between the target slide 201 and the oil dripping position can also be maintained, thus avoiding the slide from hanging at the oil outlet and dripping onto the target slide 201.

[0075] In other embodiments, the oil-dispensing position and the microscopic examination position are set to coincide. The slide transfer device 20 moves the target slide 201 to the coincident oil-dispensing position and the microscopic examination position. The oil-dispensing device 30 performs an oil-dispensing operation on the target slide 201 located at the oil-dispensing position so that the surface of the target slide 201 is at least partially covered with immersion oil. The microscopic examination device 4030 is used to perform a preset microscopic examination operation on the target slide 201 located at the microscopic examination position and covered with immersion oil.

[0076] Please see Figure 4 , Figure 4 This is a schematic diagram of the structure of a slide transfer device in a slide reading device provided in an embodiment of this application.

[0077] like Figures 2 to 4 As shown, in some embodiments, the slide transfer device 20 includes a clamping module 21 for holding a target slide 201 from a sample slide 200, and a driving module 22 for driving the clamping module 21 to move to transfer the target slide 201. When the oil-dispensing device 30 performs an oil-dispensing operation, the target slide 201 is clamped in the clamping module 21; and / or when the microscopic examination device 40 performs a microscopic examination operation, the clamping mechanism 211 is clamped in the clamping module 21.

[0078] Specifically, the slide reading device 100 controls the clamping module 21 to clamp the target slide 201 to be read, and controls the drive module 22 to drive the clamping module 21 to move relative to the oil dispensing device 30, so as to move the target slide 201 clamped by the clamping module 21 to the oil dispensing position and maintain clamping. Then, the control module 30 directly performs an oil dispensing operation on the target slide 201 clamped by the clamping module 21. The slide reading device 100 controls the drive module 22 to drive the clamping module 21 to move relative to the microscopic examination device 40, so as to move the target slide 201 clamped by the clamping module 21 to the microscopic examination position and maintain clamping. Then, the control module 30 directly performs a microscopic examination operation on the target slide 201 clamped by the clamping module 21.

[0079] It should be understood that when the slide reading device 100 performs a slide reading operation on the target slide 201, it can either control the oil dripping device 30 to perform an oil dripping operation on the target slide 201 held by the clamping module 21, or control the microscopic inspection device 40 to perform a microscopic inspection operation on the target slide 201 held by the clamping module 21. These two implementation methods can be chosen to be implemented or implemented simultaneously. By directly performing oil-spraying and / or microscopic examination operations on the target slide 201 held by the clamping module 21, there is no need to set up a corresponding support platform to support the target slide 201 to be read, nor is it necessary to control the clamping module 21 to release the target slide 201 onto the support platform before performing oil-spraying and / or microscopic examination operations. This speeds up the reading process of the slide reading equipment 100, reduces the space required by the slide reading equipment 100, and because there is no need to set up a support platform, the immersion oil overflowing from the surface of the target slide 201 will not accumulate on the support platform and contaminate the slide reading equipment 100, nor affect the subsequent reading operations of other sample slides 200.

[0080] In some embodiments, the clamping module 21 includes a clamping mechanism 211, wherein the clamping mechanism 211 includes a first clamping component 2111 and a second clamping component 2112, the first clamping component 2111 and the second clamping component 2112 are movably connected and cooperate to form a clamping opening for clamping the target glass slide 201.

[0081] Furthermore, the clamping module 21 also includes an elastic component 212 and a driving component 213. The elastic component 212 is connected to at least one of the first clamping component 2111 and the second clamping component 2112 to form an elastic clamping engagement between the first clamping component 2111 and the second clamping component 2112. The driving component 213 is used to drive the second clamping component 2112 to overcome the elastic resistance of the elastic component 212 and displace relative to the first clamping component 2111 to the side away from the first clamping component 2111 to form a clamping opening. When the driving component 213 stops driving the second clamping component 2112, the second clamping component 2112, under the action of the elastic component 212, displaces towards the side closer to the first clamping component 2111 to close the clamping opening.

[0082] Specifically, before the clamping module 21 clamps the target glass slide 201, the driving component 213 drives the second clamping component 2112 to overcome the elastic resistance of the elastic component 212 and move away from the first clamping component 2111 to form a clamping opening. When the target glass slide 201 enters the clamping opening, the driving component 213 stops driving the second clamping component 2112 or reduces the driving output. Under the action of the elastic component 212, the second clamping component 2112 moves closer to the first clamping component 2111 to close the clamping opening, so that the target glass slide 201 is clamped in the clamping opening.

[0083] It should be understood that the elastic resistance output by the elastic component 212 is positively correlated with the degree of elastic deformation of the elastic component 212. Therefore, when the clamping opening is closed, the pressure applied to both sides of the target glass slide 201 by the first clamping component 2111 and the second clamping component 2112 is stable. Through the cooperation of the elastic component 212 and the drive component 213, the clamping effect of the clamping module 21 is stabilized, and excessive pressure applied to both sides of the target glass slide 201 by the first clamping component 2111 and the second clamping component 2112 during the process of closing the clamping opening of the clamping module 21 is avoided, which would damage the target glass slide 201. It should also be understood that by setting up the elastic component 212 and closing the clamping opening through the elastic resistance output by the elastic component 212, when the reading device 100, the clamping module 21 or the drive component 213 experiences an abnormal power failure during the clamping process of the clamping module 21 clamping the target glass slide 201, the output of the drive component 213 is interrupted, and the second clamping component 2112 keeps the clamping opening closed under the action of the elastic component 212, so as to prevent the target glass slide 201 from falling.

[0084] Please see Figure 5 , Figure 5 This is an exploded structural diagram of the clamping module of a slide transfer device in a slide reading equipment provided in this application embodiment.

[0085] like Figures 2 to 5 As shown, in some embodiments, the first clamping assembly 2111 includes a first clamping arm 2113 and a first clamping member 2115 connected to the first clamping arm 2113 and at least partially exposed therefrom. The second clamping assembly 2112 includes a second clamping arm 2114 movably connected to the first clamping arm 2113 and a second clamping member 2116 connected to the second clamping arm 2114 and at least partially exposed therefrom. The thickness of the first clamping member 2115 and the second clamping member 2116 in a first direction is less than the thickness of the first clamping arm 2113 and the second clamping arm 2114 in a first direction. The first direction is the displacement direction of the second clamping assembly 2112 relative to the first clamping assembly 2111 under the action of the elastic component 212.

[0086] It should be understood that the target slide 201 is generally stored together with several other sample slides 200. For example, the target slide 201 and several sample slides 200 are stored alternately in a preset slide basket 300. When the sample slides 200 in the slide basket 300 are stored densely and the distance between adjacent sample slides 200 is close, the first clamping member 2115 and the second clamping member 2116 are difficult to clamp the target slide 201. Therefore, a first clamping member 2115 with a thickness less than the first clamping arm 2113 and a second clamping member 2116 with a thickness less than the second clamping arm 2114 are set, and the clamping module 21 is controlled to clamp the target slide 201 in a two-stage manner, so that the clamping effect of the clamping module 21 is more accurate and stable.

[0087] Specifically, the control clamping module 21 clamps the target slide 201 in a two-stage manner, including: during the first stage of clamping, the control drive component 213 cooperates with the elastic component 212 to make the first clamping member 2115 and the second clamping member 2116 cooperate to clamp the target slide 201 from the slide basket 300 and move the target slide 201 away from the slide basket 300 to a preset first position; after the target slide 201 moves to the first position ... to a preset first position. 2116 Release the clamping of the target slide 201; during the second clamping process, control the clamping module 21 to move closer to the slide basket 300. After the clamping module 21 moves to the preset second position, control the clamping module 21 to perform the second clamping operation to clamp the target slide 201 located at the first position. When the clamping module 21 performs the first clamping operation, the contact area with the target slide 201 is the first area. When the clamping module 21 performs the second clamping operation, the contact area with the target slide 201 is the second area, and the second area is greater than the first area.

[0088] It should be noted that, since the thickness of the first clamping member 2115 is less than that of the first clamping arm 2113, the thickness of the second clamping member 2116 is less than that of the second clamping arm 2114, and the second area is greater than the first area, the clamping module 21 can clamp the target glass slide 201 in a two-stage manner. This makes it easier to clamp the target glass slide 201 from a dense group of sample glass slides 200 during the first stage of clamping, and to obtain better clamping stability through a larger contact area during the second stage of clamping, making the clamping effect of the clamping module 21 more accurate and stable.

[0089] In some embodiments, the clamping mechanism 211 further includes an elastic clamping member 214, which is disposed on the first clamping arm 2113 or the second clamping arm 2114.

[0090] Specifically, when the elastic clamping member 214 is disposed on the first clamping arm 2113, the elastic clamping member 214 is disposed on opposite sides of the first clamping member 2115 to cooperate with the second clamping arm 2114 to elastically clamp the target glass slide 201; when the elastic clamping member 214 is disposed on the second clamping arm 2114, the elastic clamping member 214 is disposed on opposite sides of the second clamping member 2116 to cooperate with the first clamping arm 2113 to elastically clamp the target glass slide 201.

[0091] It should be understood that Figures 4 to 5This is merely an example of the elastic clamping member 214 being disposed on the first clamping arm 2113, and is not a limitation on the specific placement of the elastic clamping member 214. The elastic clamping member 214 can be disposed alone on the first clamping arm 2113 or the second clamping arm 2114, or it can be disposed simultaneously on both the first clamping arm 2113 and the second clamping arm 2114. The elastic clamping member 214 is used to buffer the pressure applied to both sides of the target glass slide 201 by the first clamping arm 2113 and the second clamping arm 2114 during the closing of the clamping opening of the clamping module 21, so as to avoid damage to the target glass slide 201.

[0092] In other embodiments, the slide transfer device 20 includes a second clamping module and a transport module, wherein the second clamping module is used to clamp the target slide 201 from the sample slide 200 and transport the target slide 201 to a preset transfer position, and the transport module is used to carry the target slide 201 transported to the transfer position by the second clamping module and transport the target slide 201 to a preset operation position.

[0093] For example, the second gripping module includes, but is not limited to, a robotic arm or a pushing mechanism, and the transport module includes, but is not limited to, a conveyor belt mechanism, a transport platform, or a transport trolley. The following description uses an example where the second gripping module includes a pushing mechanism and the transport module includes a conveyor belt mechanism to illustrate the image reading operation:

[0094] Specifically, the conveyor belt mechanism includes a conveyor belt assembly and a transfer drive assembly 213 for driving the conveyor belt assembly to move along a preset track. When the slide reading device 100 performs a slide reading operation on the target slide 201, it first controls the pushing mechanism to push the target slide 201 from the slide basket 300 containing the sample slide 200 to the conveyor belt assembly, so that the target slide 201 is carried on the transfer position of the conveyor belt assembly. Then, it controls the transfer drive assembly 213 to drive the conveyor belt assembly to move along the preset track, moving the target slide 201 from the transfer position to the oil-dispensing position or the microscopic examination position, so as to perform oil-dispensing operation or microscopic examination operation on the target slide 201. It should be noted that the above description is only an example of the second clamping module including a pushing mechanism and the transport module including a conveyor belt mechanism, and is not a limitation on the specific settings of the second clamping module and the transport module.

[0095] Please see Figures 6 to 7 , Figure 6 This is a schematic diagram illustrating the cooperation between the slide transfer device and the flipping mechanism of the slide reading equipment provided in the embodiments of this application. Figure 7 This is a schematic diagram of the flipping mechanism of the film reading device provided in the embodiments of this application.

[0096] like Figures 2 to 7As shown, in some embodiments, the sample introduction device 10 includes a feeding mechanism 11 and a flipping mechanism 12. The feeding mechanism 11 is used to transport the slide basket 300 loaded with sample slides 200 from a preset sample introduction area to a first preset position. The flipping mechanism 12 is used to clamp the slide basket 300 at the first preset position and perform a preset flipping operation to flip the slide basket 300 by a preset angle.

[0097] Specifically, the slide basket 300 has an opening 301. The target slide 201 and other sample slides 200 are loaded into the slide basket 300 through the opening 301. Before the reading device 100 performs the reading operation on the target slide 201, the target slide 201 and several other sample slides 200 are loaded into the slide basket 300, and the slide basket 300 is placed in a preset sample loading area. When the reading device 100 performs the reading operation on the target slide 201, the feeding mechanism 11 is controlled to transport the slide basket 300 containing the sample slides 200 from the preset sample loading area to a first preset position. Then, the flipping mechanism 12 is controlled to clamp the slide basket 300 at the first preset position and perform a preset flipping operation to flip the slide basket 300 by a preset angle.

[0098] In some embodiments, the slide basket 300 placed in the sample injection area is positioned as follows: Figure 2 In the first state with the opening facing upwards, the feeding mechanism 11 transports the slide basket 300 with the opening facing upwards from the sample loading area to the first preset position. Then, the flipping mechanism 12 is controlled to clamp the slide basket 300 at the first preset position and flip the slide basket 300 by a preset angle, so that the first state with the slide basket 300 opening upwards becomes as shown. Figure 6 The second state with the side opening shown further facilitates the slide transfer device 20 in picking up the target slide 201 from the sample slide 200 in the slide basket 300.

[0099] In some embodiments, the flipping mechanism 12, when performing a preset flipping operation, includes:

[0100] Perform a first flipping operation on the slide basket 300 to cause the slide basket 300 to flip at a first speed;

[0101] When the flipping angle of the slide basket 300 reaches the preset first angle, the control flipping device performs a second flipping operation on the slide basket 300 to drive the slide basket 300 to flip to the preset angle at a second speed, wherein the second speed is less than the first speed.

[0102] It should be understood that the target slide 201 and other sample slides 200 are loaded into the slide basket 300 through the opening 301. When the flipping mechanism 12 performs the flipping operation to change the slide basket 300 from the first state of upward opening to the second state of side opening, if the flipping speed is too fast, the sample slide 200 may slide in the slide basket 300 or even slide out of the slide basket 300, thereby causing damage to the sample slide 200.

[0103] Based on this, when performing the preset flipping operation, the flipping mechanism 12 is first controlled to perform the first flipping operation and drive the slide basket 300 to flip at the first speed. When the flipping angle of the slide basket 300 reaches the first angle, the first flipping operation is then performed and the slide basket 300 is driven to flip at the second speed, which is less than the first speed.

[0104] In some embodiments, the flipping mechanism 12 is set to correspond to a first preset position. The flipping mechanism 12 includes a receiving component 121 and a rotating component 122. The receiving component 121 forms a receiving cavity 1211 for receiving the slide basket 300. The receiving cavity 1211 has a receiving opening 1212 for the slide basket 300 to enter and exit. The receiving cavity 1211 corresponds to the first preset position. The rotating component 122 is used to drive the receiving component 121 to flip so as to drive the slide basket 300 contained in the receiving cavity 1211 to flip.

[0105] Specifically, the receiving cavity 1211 corresponds to the first preset position. First, the feeding mechanism 11 is controlled to transport the slide basket 300 loaded with the sample slide 200 from the receiving opening 1212 into the receiving cavity 1211 corresponding to the first preset position, so that the flipping mechanism 12 clamps the slide basket 300.

[0106] Specifically, the rotating component 122 includes, but is not limited to, a motor. Taking the rotating component 122 including a motor as an example: the motor output terminal 1221 of the rotating component 122 is connected to the receiving cavity 1211, and the rotating component 122 is controlled to drive the receiving component 121 to rotate through the motor output terminal 1221, so that the glass slide basket 300 that is contained in the receiving cavity 121 by the receiving component 121 is rotated.

[0107] For example, the receiving assembly 121 includes a first clamping plate 1213 connected to the output end of the rotating assembly 122, a second clamping plate 1214 spaced apart from the first clamping plate 1213, and a connecting plate 1212 connecting the first clamping plate 1213 and the second clamping plate 1214, wherein the first clamping plate 1213, the second clamping plate 1214 and the connecting plate 1212 cooperate to form a receiving cavity 1211.

[0108] In some embodiments, the rotating component 122 drives the receiving component 121 to rotate, thereby causing the slide basket 300 housed in the receiving cavity 1211 to rotate. This includes: the rotating component 122 driving the receiving component 121 to rotate at a first speed, thereby causing the slide basket 300 to rotate at the first speed; when the rotation angle of the slide basket 300 reaches a preset first angle, the rotating component 122 driving the receiving component 121 to rotate at a second speed, thereby causing the slide basket 300 to rotate at the second speed to a preset angle, wherein the second speed is less than the first speed. By controlling the rotation speed of the rotating component 122 driving the receiving component 121 to adjust the rotation speed of the slide basket 300, the rotation speed of the slide basket 300 is easily controlled, and the sample slide 200 is prevented from falling out of the slide basket 300 due to excessive rotation speed, thus avoiding damage to the sample slide 200.

[0109] In some embodiments, the slide reading device 100 is provided with a rotation sensor connected to the rotation assembly 122, and the rotation sensor senses the angle at which the rotation assembly 122 drives the receiving assembly 121 to rotate, so as to determine whether the rotation angle of the slide basket 300 has reached a first angle or a preset angle.

[0110] In other embodiments, the slide reading device 100 is provided with an optical sensor 123, and the optical sensor 123 senses the angle at which the rotating component 122 drives the receiving component 121 to flip, so as to determine whether the flip angle of the slide basket 300 has reached a first angle or a preset angle. The optical sensor 123 includes, but is not limited to, an optical coupler or an optical imaging component.

[0111] It should be noted that the slide reading device 100 can be implemented in two ways: by sensing the angle of rotation of the rotating component 122 to drive the receiving component 121 to flip through a rotation sensor, and by sensing the angle of rotation of the rotating component 122 to drive the receiving component 121 to flip through an optical sensor 123. Either one of these two methods can be implemented, or both can be implemented. That is, the flip angle of the slide basket 300 can be determined by combining the sensing results of the rotation sensor and the detection results of the optical sensor 123.

[0112] like Figure 8 As shown, in some embodiments, the slide reading device 100 further includes an immersion oil recovery device 50, which is at least used to recover the immersion oil that overflows from the surface of the target slide 201 when the target slide 201 is at the dripping oil position.

[0113] Furthermore, the immersion oil recovery device 50 is also used to recover the immersion oil that overflows from the surface of the target slide 201 when the target slide 201 is in the microscopic examination position.

[0114] Specifically, the microscopic examination device 40 includes an image acquisition component 41 and a light source component 42 corresponding to the image acquisition component 41. The image acquisition component 41 is used to acquire images of the target slide 201 located at the microscopic examination position, and the light source component 42 is used to provide illumination to the target slide 201 located at the microscopic examination position to improve the image quality acquired by the image acquisition component 41. The image acquisition component 41 includes, but is not limited to, a combination of a camera and a lens group.

[0115] Specifically, the immersion oil recovery device 50 includes an immersion oil recovery component 51, which is disposed around the light source assembly 42. The immersion oil recovery component 51 forms an immersion oil recovery tank 52 for recovering immersion oil. The immersion oil recovery tank 52 is used to recover immersion oil that spills from the target slide 201 during immersion oil application, at the microscopic examination position, or during transportation. The immersion oil recovery tank 52 has at least one recovery tank opening 53 corresponding to the oil application position, so that the spilled immersion oil flows into the immersion oil recovery tank 52 from the recovery tank opening 53 to complete the collection of immersion oil. By placing the immersion oil recovery device 50 on the light source assembly 42, the installation space of the immersion oil recovery device 50 is saved. Furthermore, since the light source assembly 42 is located directly below the microscopic examination position, the immersion oil spilled from the target slide 201 during microscopic examination can be fully recovered.

[0116] It should be understood that the immersion oil recovery unit 51 can also be used to recover immersion oil that overflows from the surface of the target slide 201 at the oil-drip position, especially when the target slide 201 is at the oil-drip position and the oil-drip device 30 drips excessive immersion oil onto the target slide 201. It should be understood that by increasing the size of the immersion oil recovery unit 51 and adjusting the size of the recovery tank opening 53 of the immersion oil recovery unit 51, the immersion oil recovery unit 51 can recover not only the immersion oil overflowing from the target slide 201 at the microscopic inspection position, but also the immersion oil overflowing from the target slide 201 at the oil-drip position.

[0117] The slide reading device 100 provided in this application embodiment avoids being contaminated by immersion oil during the microscopic examination of the sample slide 200 by the immersion oil recovery device 50.

[0118] This application also provides a film reading method, which aims to solve the problems that existing film reading equipment has a complex structure, occupies a large volume, and has a lengthy and time-consuming reading process.

[0119] It should be noted that the film reading method can be specifically applied to the film reading device 100 provided in the above embodiments. The following will take the film reading device 100 provided in the above embodiments as an example to describe the steps of the film reading method provided in this application in detail. However, it should be understood that the film reading method is not limited to the film reading device 100 provided in the above embodiments.

[0120] Please see Figure 9 , Figure 9This is a schematic diagram of the image reading method provided in an embodiment of this application.

[0121] like Figure 9 As shown, the image viewing method provided in this application includes steps S1-S5:

[0122] Step S1: Feed the sample slide to be tested;

[0123] Step S2: Pick up the target slide from the sample slide and transfer the target slide to the oil-dropping position, wherein the oil-dropping position is equipped with an oil-dropping device.

[0124] Step S3: Control the oil-drip device to perform an oil-drip operation on the target glass slide located at the oil-drip position;

[0125] Step S4: Transfer the target slide to the oil dripping point;

[0126] Step S5: Perform microscopic examination on the target slide located in the microscopic examination position.

[0127] Specifically, in combination Figures 1 to 9 The following description uses the slide reading method applied to the slide reading device 100 provided in the embodiments of this application as an example: The slide reading device 100 first controls the sample injection device 10 to acquire at least one sample slide 200 to be tested, controls the transfer device 20 to pick up the target slide 201 from the at least one sample slide 200, and transfers the target slide 201 to the oil-dropping position, wherein the oil-dropping position is correspondingly provided with an oil-dropping device 30, controls the oil-dropping device 30 to perform a preset oil-dropping operation on the target slide 201 located at the oil-dropping position, so that the surface of the target slide 201 is at least partially covered with immersion oil, then controls the transfer device 20 to transfer the target slide 201 to the microscopic inspection position, and then controls the microscopic inspection device 40 to perform a preset microscopic inspection operation on the target slide 201 located at the microscopic inspection position.

[0128] In summary, this invention provides a slide reading device and a slide reading method. The slide reading device 100 includes: a sample introduction device 10 for acquiring a sample slide 200 to be tested; a slide transfer device 20 for picking up a target slide 201 from the sample slide 200 and transferring the target slide 201 to a preset operation position, the operation position including an oil-dropping position and a microscopic inspection position; an oil-dropping device 30, which is set corresponding to the oil-dropping position and is used to perform a preset oil-dropping operation on the target slide 201 transferred to the oil-dropping position, so that the surface of the target slide 201 is at least partially covered with immersion varnish; and a microscopic inspection device 40 for performing a preset microscopic inspection operation on the target slide 201 transferred to the microscopic inspection position and covered with immersion varnish. The slide reading device 100 provided by this invention, by using the oil-dropping device 30 set corresponding to the oil-dropping position to perform a preset oil-dropping operation on the target slide 201 transferred to the oil-dropping position, solves the problems of the complex structure and large volume of existing slide reading devices, as well as the problems of the lengthy slide reading process and the long processing time.

[0129] It should be understood that the modular structure diagrams shown in the accompanying drawings are merely illustrative and do not necessarily include all the connections between structures. In the description of this application, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linkage" should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0130] It should also be understood that the terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to limit the scope of the application. As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” are intended to include the plural forms unless the context clearly indicates otherwise.

[0131] It should also be understood that the term “and / or” as used in this application specification and the appended claims means any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0132] It should also be understood that the term "and / or" as used in this specification and the appended claims refers to any combination and all possible combinations of one or more of the associated listed items, and includes such combinations. It should be noted that, herein, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or system that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or system. Without further limitation, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or system that includes that element.

[0133] The sequence numbers of the embodiments in this application are for descriptive purposes only and do not represent the superiority or inferiority of the embodiments. The above descriptions are merely specific implementations of this application, but the scope of protection of this application is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in this application, and these modifications or substitutions should all be covered within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A reading apparatus, characterized by include: The sample introduction device is used to feed the sample slide to be tested; A slide transfer device is used to pick up a target slide from the sample slide and transfer the target slide to an operating position, the operating position including an oil-dropping position and a microscopic examination position; An oil-drip device is provided corresponding to the oil-drip position and is used to perform an oil-drip operation on the target glass slide located at the oil-drip position; Microscopic examination device for performing microscopic examination on the target slide located at the microscopic examination position; The slide transfer device includes a clamping module for clamping the target slide from the sample slide and a driving module for driving the clamping module to move. The clamping module includes a clamping mechanism, which includes a first clamping component and a second clamping component. The first clamping component and the second clamping component are movably connected and cooperate to form a clamping opening for clamping the target slide. The first clamping assembly includes a first clamping arm and a first clamping member connected to the first clamping arm and at least partially exposed outside the first clamping arm. The second clamping assembly includes a second clamping arm movably connected to the first clamping arm and a second clamping member connected to the second clamping arm and at least partially exposed outside the second clamping arm. The thickness of the first clamping member and the second clamping member in a first direction is less than the thickness of the first clamping arm and the second clamping arm in the first direction. The first direction is the displacement direction of the second clamping assembly relative to the first clamping assembly. The slide transfer device picks up the target slide from the sample slide, including: During the first clamping process, the first clamping member and the second clamping member cooperate to clamp the target glass slide from the slide basket and move the target glass slide away from the slide basket to a preset first position. After the target glass slide moves to the first position, the first clamping member and the second clamping member release the clamping member from the target glass slide. During the second clamping process, the clamping module moves closer to the slide basket. After the clamping module moves to the preset second position, it performs a second clamping operation to clamp the target slide located at the first position. When the clamping module performs the first clamping operation, the contact area with the target slide is a first area. When the clamping module performs the second clamping operation, the contact area with the target slide is a second area, and the second area is greater than the first area.

2. The film reading device according to claim 1, characterized in that, When the oil-drip device performs the oil-drip operation, the target glass slide is clamped in the clamping module; And / or, When the microscopic examination device performs the microscopic examination operation, the target slide is clamped in the clamping module.

3. The film reading device according to claim 2, characterized in that, The clamping module further includes an elastic component and a first driving component. The elastic component is connected to at least one of the first clamping component and the second clamping component to form an elastic clamping engagement between the first clamping component and the second clamping component. The first driving component is at least used to drive the second clamping component to overcome the elastic resistance of the elastic component and displace relative to the first clamping component to the side away from the first clamping component to form the clamping opening. When the driving component stops driving the second clamping component, the second clamping component is displaced towards the side closer to the first clamping component under the action of the elastic component to close the clamping opening.

4. The film reading device according to claim 3, characterized in that, The first clamping assembly includes a first clamping arm and a first clamping member connected to the first clamping arm and at least partially exposed outside the first clamping arm; the second clamping assembly includes a second clamping arm movably connected to the first clamping arm and a second clamping member connected to the second clamping arm and at least partially exposed outside the second clamping arm. Wherein, the thickness of the first clamping member and the second clamping member in the first direction is less than the thickness of the first clamping arm and the second clamping arm in the first direction, and the first direction is the displacement direction of the second clamping component relative to the first clamping component under the action of the elastic component.

5. The film reading device according to claim 4, characterized in that, The clamping mechanism further includes an elastic clamping member, which is disposed on the side of the first clamping arm facing the second clamping arm or the side of the second clamping arm facing the first clamping arm.

6. The film reading device according to claim 1, characterized in that, The slide transfer device includes: The second clamping module is used to clamp the target glass slide from the sample glass slide and transport the target glass slide to a preset transfer position; A transport module is used to carry the target glass slide transported by the second clamping module to the transfer position, and to transport the target glass slide to a preset operation position.

7. The film reading device according to any one of claims 1-6, characterized in that, The sample introduction device includes: A feeding mechanism for feeding a slide basket containing the sample slides; A flipping mechanism is used to receive the slide basket from the feeding mechanism and flip the slide basket by a preset angle.

8. The film reading device according to claim 7, characterized in that, The flipping mechanism, when flipping the slide basket by a preset angle, includes: The glass slide basket is rotated at a first speed; When the glass slide basket reaches a preset first angle, it is driven to rotate to the preset angle at a second speed, wherein the second speed is less than the first speed.

9. The film reading device according to any one of claims 1-6, characterized in that, The microscopic examination position and the oil drop position are spaced apart, and the horizontal distance between the microscopic examination position and the oil drop position is greater than the width of the target slide.

10. The film reading device according to any one of claims 1-6, characterized in that, The slide reading device also includes an immersion oil recovery device, which is used at least to recover the immersion oil that overflows from the surface of the target slide when the oil dripping point is reached.

11. A method for viewing films, characterized in that, include: Feed the sample slide to be tested; The target slide is picked up from the sample slide by a slide transfer device and transferred to the oil-dropping position, which is equipped with an oil-dropping device. The oil-drip device is controlled to perform an oil-drip operation on the target glass slide located at the oil-drip position; Transfer the target slide to the microscopic examination position; Perform microscopic examination on the target slide located at the microscopic examination position; The slide transfer device includes a clamping module for clamping the target slide from the sample slide and a driving module for driving the clamping module to move. The clamping module includes a clamping mechanism, which includes a first clamping component and a second clamping component. The first clamping component and the second clamping component are movably connected and cooperate to form a clamping opening for clamping the target slide. The first clamping assembly includes a first clamping arm and a first clamping member connected to the first clamping arm and at least partially exposed outside the first clamping arm. The second clamping assembly includes a second clamping arm movably connected to the first clamping arm and a second clamping member connected to the second clamping arm and at least partially exposed outside the second clamping arm. The thickness of the first clamping member and the second clamping member in a first direction is less than the thickness of the first clamping arm and the second clamping arm in the first direction. The first direction is the displacement direction of the second clamping assembly relative to the first clamping assembly. The step of picking up the target glass slide from the sample glass slide using a glass slide transfer device includes: During the first clamping process, the first clamping member and the second clamping member cooperate to clamp the target glass slide from the slide basket and move the target glass slide away from the slide basket to a preset first position. After the target glass slide moves to the first position, the first clamping member and the second clamping member release the clamping member from the target glass slide. During the second clamping process, the clamping module moves closer to the slide basket. After the clamping module moves to the preset second position, it performs a second clamping operation to clamp the target slide located at the first position. When the clamping module performs the first clamping operation, the contact area with the target slide is a first area. When the clamping module performs the second clamping operation, the contact area with the target slide is a second area, and the second area is greater than the first area.

Images