A synchronized multi-channel multi-polarity sharp pulse generating device for tissue ablation

Abstract

The application provides a synchronous multi-channel multi-polarity steep pulse generating device for tissue ablation, which comprises an energy storage device, a switch, a transmission line group and a load. The main feature is that the transmission line group is composed of multiple parallel or series transmission lines, the input end of the transmission line group is connected with the energy storage device in series through the switch, and the inner conductors at the output end of the transmission line group form different polarities of ground potential. The transmission lines can independently drive the load and output different polarities of steep pulses on different loads; two transmission lines with opposite polarities of inner conductor potential can cooperatively drive the load in series and output synchronous bipolar steep pulses on different loads. The application creatively provides a synchronous multi-channel multi-polarity steep pulse generating device for tissue ablation, which can be widely applied to the treatment of various tumor and lesion tissues in human body. Compared with the prior art, in the specific implementation, the synchronous multi-channel multi-polarity steep pulse output can realize the ablation of larger tumor tissues or irregularly shaped tissues at one time, and at the same time, it can actively shield the adjacent important tissues to prevent them from being damaged by the electric field.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of electromagnetic field tumor treatment in medical devices, in particular to high-voltage pulsed electric field tumor tissue ablation and cell processing. BACKGROUND

[0002] Cancer seriously endangers human life and health. Radiofrequency-based thermal ablation therapy is limited in clinical application due to the influence of the thermal sinking effect of the solution in the surrounding pipeline structure. In recent years, ablation therapy based on irreversible electroporation is a new type of non-thermal ablation technology, which uses high-voltage pulsed electric field to cause irreversible electroporation of cell membranes to achieve tumor ablation. Compared with thermal ablation technology, it has clear ablation boundaries and can effectively avoid damage to important blood vessels, bile ducts and nerves, etc. structure, so that more tumor patients can get treatment opportunities and achieve significant clinical effects.

[0003] The voltage waveform used by the pulsed electric field ablation device is mostly unipolar pulse, bipolar pulse or pulse combination, and the pulse width is from nanosecond to microsecond. In actual operation, at least a pair of ablation electrode needles are required. The ablation voltage is negatively related to the pulse width. The narrower the pulse, the higher the ablation voltage threshold. The higher the voltage, the larger the ablation range, but too high voltage is easy to cause breakdown of the tissue or insulation layer between the electrode needles, so the ablation range of a single pair of electrode needles is limited. For large tumor tissues or irregularly shaped tissues, the electrode needle position needs to be adjusted multiple times during the ablation process. In order to obtain a large ablation area, multiple electrode needles are used in clinical practice. The current ablation device outputs high-voltage pulses to different electrode pairs in sequence through a fast switching device (such as patents 2020112024303 and 201910247941.8), which complicates the operation process, increases the treatment time, and also increases the risk of patients during the operation. In addition, the ground potential of the high-voltage electrode needles in the current ablation device is the same, which prevents the formation of an effective ablation electric field between the high-voltage electrodes, which is not conducive to the formation of an effective ablation electric field network, thereby affecting the ablation range. SUMMARY

[0004] In view of the above technical defects of pulsed ablation, the present application creatively proposes a novel synchronous multi-channel multi-polarity pulse generation device for tissue ablation.

[0005] A synchronous multi-channel multi-polarity pulse generation device, comprising an energy storage device, a switch, a load and a transmission line group. Its characteristic is that the transmission line group is composed of multiple parallel or series transmission lines, and the input end of the transmission line group is connected in series with the energy storage device through the switch. The inner conductors at the output end of the transmission line group form ground potentials with different polarities. Each transmission line can independently drive the load and output steep pulses with different polarities on different loads; two transmission lines with opposite polarities of the inner conductors can be connected in series to cooperatively drive the load and output synchronous bipolar steep pulses on different loads.

[0006] When the number of transmission lines in a transmission line group is even, the outer conductors at the input end of the transmission line group are connected to ground in parallel; when the number of transmission lines in a transmission line group is odd, the outer conductors at the output end of the transmission line group are connected to ground in parallel.

[0007] The number of switches can be one or two. When there are two switches, the two ends of the energy storage device are connected to the input terminals of the transmission line group through the switches respectively.

[0008] The switch is characterized in that it includes, but is not limited to, spark gap switches, magnetic switches, semiconductor switches, etc.

[0009] The energy storage devices include, but are not limited to, capacitors, pulse forming lines, artificial forming lines, pulse generators, etc.

[0010] The load includes, but is not limited to, biological tissues, tumors, cells, microorganisms, etc.

[0011] This invention creatively proposes a synchronous multi-channel multi-polarity pulse generator, which has the following advantages: it can achieve synchronous output of multiple multi-channel multi-polarity pulses; the polarity of the electrode needles for grounding is flexible and diverse, and can be positive, negative, or zero potential; an effective ablation electric field network can be easily formed between the electrode needles, enabling the simultaneous coverage of large volumes of tumor tissue or irregular lesions; electrodes with opposite potential polarities can work synergistically, reducing the voltage of the electrode needles to ground by half while ensuring the ablation range, significantly reducing the insulation requirements of the pulse generator to ground, making it safer and more reliable. Furthermore, based on the "Faraday cage" electromagnetic shielding effect, the use of a zero-potential electrode needle array can protect vital organs near the ablation zone from the influence of the external electric field. Attached Figure Description

[0012] Figure 1 This is an embodiment of the present invention based on single-channel bipolar pulse output of a two-stage transmission line.

[0013] Figure 2 This is the pulse voltage waveform of the single-channel bipolar pulse output based on a two-stage transmission line according to the present invention.

[0014] Figure 3 This is an embodiment of the present invention based on two independent positive and negative pulse outputs using a two-stage transmission line.

[0015] Figure 4 This is an embodiment of the present invention based on two-channel bipolar pulse output of a three-stage transmission line.

[0016] Figure 5 This is an embodiment of the present invention based on three independent positive and negative pulse outputs using a three-stage transmission line.

[0017] Figure 6An embodiment of the application based on four-stage transmission line parallel four-way independent positive and negative pulse output.

[0018] Figure 7 An embodiment of the application based on two-way bipolar pulse output of four-stage transmission line in series.

[0019] Figure 8 An embodiment of the application based on two-way bipolar pulse output of four-stage transmission line in series.

[0020] Figure 9 An embodiment of the application based on four-stage transmission line in series four-way independent positive and negative pulse output.

[0021] Figure 10 An embodiment of the application based on two-stage transmission line single bipolar pulse output ablation of liver tumors.

[0022] Figure 11 An embodiment of the application based on two-stage transmission line single bipolar pulse output ablation of liver tumor range cross-sectional schematic.

[0023] Figure 12 An embodiment of the application based on two-stage transmission line two-way independent positive and negative pulse output ablation of liver tumors.

[0024] Figure 13 An embodiment of the application based on two-stage transmission line two-way independent positive and negative pulse output ablation of liver tumor range cross-sectional schematic.

[0025] Figure 14 An embodiment of the application based on two-stage transmission line two-way independent positive and negative pulse output ablation of specific shape liver tumors.

[0026] Figure 15 An embodiment of the application based on two-stage transmission line two-way independent positive and negative pulse output ablation of irregular shape liver tumors cross-sectional schematic.

[0027] Figure 16 An embodiment of the application based on pulse forming line energy storage.

[0028] Figure 17 An embodiment of the application based on artificial formation line energy storage.

[0029] Figure 18 An embodiment of the application based on double switch multi-way output.

[0030] Figure 19 An embodiment of the application based on Blumlein pulse forming line.

[0031] Fig. 1: 1, capacitor energy storage device; 2, switch; 3, transmission line; 4, inner conductor of transmission line input end; 5, transmission line; 6, inner conductor of transmission line input end; 7, outer conductor of transmission line input end; 8, outer conductor of transmission line input end; 9, ground; 10, load; 11, inner conductor of transmission line output end; 12, inner conductor of transmission line output end; 13, outer conductor of transmission line output end; 14, outer conductor of transmission line output end; 15, positive polarity pulse waveform; 16, negative polarity pulse waveform; 17, pulse voltage waveform across load; 18, load; 19, load; 20, transmission line; 21, transmission line; 22, outer conductor of transmission line input end; 23, inner conductor of transmission line input end; 24, inner conductor of transmission line input end; 25, outer conductor of transmission line input end; 26, load; 27, load; 28, inner conductor of transmission line output end; 29, outer conductor of transmission line output end; 30, inner conductor of transmission line output end; 31, outer conductor of transmission line output end; 32, ground; 33, load; 34, load; 35, load; 36, transmission line; 37, transmission line; 38, transmission line; 39, inner conductor of transmission line input end; 40, outer conductor of transmission line input end; 41, inner conductor of transmission line input end; 42, outer conductor of transmission line input end; 43, inner conductor of transmission line input end; 44, outer conductor of transmission line input end; 45, ground; 46, load; 47, load; 48, load; 49, load; 50, inner conductor of transmission line output end; 51, outer conductor of transmission line output end; 52, inner conductor of transmission line output end; 53, outer conductor of transmission line output end; 54, inner conductor of transmission line output end; 55, outer conductor of transmission line output end; 56, load; 57, load; 58, liver; 59, tumor in liver; 60, electrode needle; 61, electrode needle; 62, electrode needle; 63, electrode needle; 64, electric field action range; 65, pulse forming line energy storage device; 66, artificially formed line energy storage device; 67, switch; 68, Blumlein pulse forming line. DETAILED DESCRIPTION

[0032] In order to describe the present application in more detail, the technical solutions of the present application are described in detail below in combination with the drawings and specific embodiments.

[0033] Example 1

[0034] As Figure 1As shown, a multi-channel, multi-polar steep pulse generator for tissue ablation includes an energy storage device 1, a switch 2, a transmission line 3, a transmission line 5, and a load 10. The energy storage device 1 is a capacitor. The device is characterized in that one end of the energy storage device 1 is connected to the inner conductor 4 of the input terminal of the transmission line 3 via the switch 2, and the other end of the energy storage device 1 is connected to the inner conductor 6 of the input terminal of the transmission line 5. The outer conductor 7 of the input terminal of the transmission line 3 is connected to the outer conductor 8 of the input terminal of the transmission line 5, and is connected to ground 9. The two ends of the load 10 are respectively connected to the inner conductor 11 of the output terminal of the transmission line 3 and the inner conductor 12 of the output terminal of the transmission line 5, and the outer conductor 13 of the output terminal of the transmission line 3 and the outer conductor 14 of the output terminal of the transmission line 5. A unipolar pulse is output on the load 10, but the potential polarities at both ends of the load are opposite, and the amplitude of each pulse is half of the voltage V on the energy storage device 1. A voltage waveform diagram is shown below. Figure 2 As shown, waveform 16 is the output voltage waveform of the inner conductor 12 at the output terminal of transmission line 5 to ground, with an amplitude of -V / 2. Waveform 15 is the output voltage waveform of the inner conductor 11 at the output terminal of transmission line 3 to ground, with an amplitude of +V / 2. Waveform 17 is the pulse voltage waveform across the load 10, with an amplitude of V.

[0035] Example 2

[0036] like Figure 3 As shown, a multi-channel, multi-polarity steep pulse generator for tissue ablation includes an energy storage device 1, a switch 2, a transmission line 3, a transmission line 5, a load 18, and a load 19. The energy storage device 1 is a capacitor. The device is characterized in that one end of the energy storage device 1 is connected to the inner conductor 4 of the input terminal of the transmission line 3 via the switch 2, and the other end of the energy storage device 1 is connected to the inner conductor 6 of the input terminal of the transmission line 5. The outer conductor 7 of the input terminal of the transmission line 3 is connected to the outer conductor 8 of the input terminal of the transmission line 5, and is connected to ground 9. The two ends of the load 18 are respectively connected to the inner conductor 11 and the outer conductor 13 of the output terminal of the transmission line 3, outputting a positive high-voltage pulse with an amplitude of half the voltage V on the energy storage device 1, i.e., +V / 2. The two ends of the load 19 are respectively connected to the inner conductor 12 and the outer conductor 14 of the output terminal of the transmission line 5, outputting a negative high-voltage pulse with an amplitude of half the voltage V on the energy storage device 1, i.e., -V / 2.

[0037] Example 3

[0038] like Figure 4As shown, a multi-channel, multi-polarity steep pulse generator for tissue ablation includes an energy storage device 1, a switch 2, a transmission line 3, a transmission line 20, a transmission line 21, a load 26, and a load 27. The energy storage device 1 is a capacitor. The device is characterized in that one end of the energy storage device 1 is connected to the inner conductor 4 of the input terminal of the transmission line 3 via the switch 2, and the other end of the energy storage device 1 is connected to the outer conductor 25 of the input terminal of the transmission line 21; the outer conductor 7 of the input terminal of the transmission line 3 is connected to the outer conductor 22 of the input terminal of the transmission line 20; and the inner conductor 23 of the input terminal of the transmission line 20 is connected to the inner conductor 24 of the input terminal of the transmission line 21. The two ends of the load 26 are respectively connected to the inner conductor 11 of the output terminal of the transmission line 3 and the inner conductor 28 of the output terminal of the transmission line 20, outputting a high-voltage pulse with an amplitude of 2V / 3 of the voltage V on the energy storage device 1. The two ends of load 27 are connected to the inner conductor 28 at the output end of transmission line 20 and the inner conductor 30 at the output end of transmission line 21, respectively. A high-voltage pulse is output on load 27, with an amplitude of 2V / 3 of the voltage V on energy storage device 1. The outer conductor 13 at the output end of transmission line 3, the outer conductor 29 at the output end of transmission line 20, and the outer conductor 31 at the output end of transmission line 21 are connected together and then connected to ground 32. The potentials of the inner conductor 11 at the output end of transmission line 3, the inner conductor 28 at the output end of transmission line 20, and the inner conductor 30 at the output end of transmission line 21 are +V / 3, -V / 3, and +V / 3, respectively.

[0039] Example 4

[0040] like Figure 5 As shown, a multi-channel, multi-polarity steep pulse generator for tissue ablation includes an energy storage device 1, a switch 2, a transmission line 3, a transmission line 20, a transmission line 21, a load 33, a load 34, and a load 35. The energy storage device 1 is a capacitor. The device is characterized in that one end of the energy storage device 1 is connected to the inner conductor 4 of the input end of the transmission line 3 via the switch 2, and the other end of the energy storage device 1 is connected to the outer conductor 25 of the input end of the transmission line 21. The outer conductor 7 of the input end of the transmission line 3 is connected to the outer conductor 22 of the input end of the transmission line 20. The inner conductor 23 of the input end of the transmission line 20 is connected to the inner conductor 24 of the input end of the transmission line 21. The outer conductors 13, 29, 31, and 31 of the output ends of the transmission lines 3, 21, and 22 are connected together and then connected to ground 32. The two ends of the load 33 are connected to the inner conductor 11 and the outer conductor 13 of the output end of the transmission line 3, respectively, and a high-voltage pulse is output on the load 33, with an amplitude of 1 / 3 of the voltage V on the energy storage device 1, i.e., V / 3. The two ends of load 34 are connected to the inner conductor 28 and the outer conductor 29 of the output end of transmission line 20, respectively. A high-voltage pulse is output on load 34, with an amplitude of -1 / 3 of the voltage V on energy storage device 1, i.e., -V / 3. The two ends of load 35 are connected to the inner conductor 30 and the outer conductor 31 of the output end of transmission line 21, respectively. A high-voltage pulse is output on load 35, with an amplitude of 1 / 3 of the voltage V on energy storage device 1, i.e., V / 3.

[0041] Example 5

[0042] As Figure 6 shown, a multi-path multi-polarity steep pulse generating device for tissue ablation includes an energy storage device 1, a switch 2, a transmission line 3, a transmission line 36, a transmission line 37, a transmission line 38, a load 46, a load 47, a load 48, a load 49, and the energy storage device 1 is a capacitor. Its features are that one end of the energy storage device 1 is connected to the inner conductor 4 of the input end of the transmission line 3 through the switch 2, and the other end of the energy storage device 1 is connected to the inner conductor 43 of the input end of the transmission line 38; the outer conductor 7 of the input end of the transmission line 3, the outer conductor 40 of the input end of the transmission line 36, the outer conductor 42 of the input end of the transmission line 37, and the outer conductor 44 of the input end of the transmission line 38 are connected together and then connected to the ground 45; the inner conductor 4 of the input end of the transmission line 3 is connected to the inner conductor 39 of the input end of the transmission line 36; and the inner conductor 41 of the input end of the transmission line 37 is connected to the inner conductor 43 of the input end of the transmission line 38. The outer conductor 13 of the output end of the transmission line 3, the outer conductor 51 of the output end of the transmission line 36, the outer conductor 53 of the output end of the transmission line 37, and the outer conductor 55 of the output end of the transmission line 38 are connected together. The two ends of the load 46 are respectively connected to the inner conductor 11 and the outer conductor 13 of the output end of the transmission line 3, and a high-voltage pulse with an amplitude of 1 / 2 of the voltage V on the energy storage device 1, i.e., V / 2, is output on the load 46. The two ends of the load 47 are respectively connected to the inner conductor 50 and the outer conductor 51 of the output end of the transmission line 36, and a high-voltage pulse with an amplitude of 1 / 2 of the voltage V on the energy storage device 1, i.e., V / 2, is output on the load 47. The two ends of the load 48 are respectively connected to the inner conductor 52 and the outer conductor 53 of the output end of the transmission line 37, and a high-voltage pulse with an amplitude of -1 / 2 of the voltage V on the energy storage device 1, i.e., -V / 2, is output on the load 48. The two ends of the load 49 are respectively connected to the inner conductor 54 and the outer conductor 55 of the output end of the transmission line 38, and a high-voltage pulse with an amplitude of -1 / 2 of the voltage V on the energy storage device 1, i.e., V / 2, is output on the load 49.

[0043] Example 6

[0044] As Figure 7As shown, a multi-path multi-polarity steep pulse generating device for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 36, a transmission line 37, a transmission line 38, a load 56, a load 57, the energy storage device 1 being a capacitor. Its features are that one end of the energy storage device 1 is connected to the inner conductor 4 of the input end of the transmission line 3 through the switch 2, and the other end of the energy storage device 1 is connected to the inner conductor 43 of the input end of the transmission line 38; the outer conductor 7 of the input end of the transmission line 3, the outer conductor 40 of the input end of the transmission line 36, the outer conductor 42 of the input end of the transmission line 37, and the outer conductor 44 of the input end of the transmission line 38 are connected together and then connected to the ground 45; the inner conductor 4 of the input end of the transmission line 3 is connected to the inner conductor 39 of the input end of the transmission line 36; and the inner conductor 41 of the input end of the transmission line 37 is connected to the inner conductor 43 of the input end of the transmission line 38. The outer conductor 13 of the output end of the transmission line 3, the outer conductor 51 of the output end of the transmission line 36, and the outer conductor 53 of the output end of the transmission line 37 are connected together, and the outer conductor 55 of the output end of the transmission line 38 is connected together. The two ends of the load 56 are respectively connected to the inner conductor 11 of the output end of the transmission line 3 and the inner conductor 54 of the output end of the transmission line 38, and a high-voltage pulse with an amplitude equal to the voltage V on the energy storage device 1 is output on the load 56; the potentials of the inner conductor 11 of the output end of the transmission line 3 and the inner conductor 54 of the output end of the transmission line 38 are +V / 2 and -V / 2 respectively. The two ends of the load 57 are respectively connected to the inner conductor 50 of the output end of the transmission line 36 and the inner conductor 52 of the output end of the transmission line 37, and a high-voltage pulse with an amplitude equal to the voltage V on the energy storage device 1 is output on the load 57; the potentials of the inner conductor 50 of the output end of the transmission line 36 and the inner conductor 52 of the output end of the transmission line 37 are +V / 2 and -V / 2 respectively.

[0045] Example 7

[0046] As Figure 8As shown, a multi-path multi-polarity steep pulse generating device for tissue ablation includes an energy storage device 1, a switch 2, a transmission line 3, a transmission line 36, a transmission line 37, a transmission line 38, a load 56, a load 57, the energy storage device 1 being a capacitor. Its features are that one end of the energy storage device 1 is connected to the inner conductor 4 of the input end of the transmission line 3 through the switch 2, and the other end of the energy storage device 1 is connected to the inner conductor 43 of the input end of the transmission line 38; the outer conductor 7 of the input end of the transmission line 3 is connected to the outer conductor 40 of the input end of the transmission line 36; the outer conductor 42 of the input end of the transmission line 37 is connected to the outer conductor 44 of the input end of the transmission line 38; the inner conductor 39 of the input end of the transmission line 36 is connected to the inner conductor 41 of the input end of the transmission line 37. The outer conductor 13 of the output end of the transmission line 3, the outer conductor 51 of the output end of the transmission line 36, the outer conductor 53 of the output end of the transmission line 37 are connected together, and the outer conductor 55 of the output end of the transmission line 38 is connected together, and is connected to the ground 45. The two ends of the load 56 are respectively connected to the inner conductor 11 of the output end of the transmission line 3 and the inner conductor 54 of the output end of the transmission line 38, and a high-voltage pulse with an amplitude of 1 / 2 of the voltage V on the energy storage device 1 is output on the load 56; the potentials of the inner conductor 11 of the output end of the transmission line 3 and the inner conductor 54 of the output end of the transmission line 38 are +V / 4 and -V / 4 respectively. The two ends of the load 57 are respectively connected to the inner conductor 50 of the output end of the transmission line 36 and the inner conductor 52 of the output end of the transmission line 37, and a high-voltage pulse with an amplitude of 1 / 2 of the voltage V on the energy storage device 1 is output on the load 57; the potentials of the inner conductor 50 of the output end of the transmission line 36 and the inner conductor 52 of the output end of the transmission line 37 are -V / 4 and +V / 4 respectively.

[0047] Example 8

[0048] As Figure 9As shown, a multi-channel, multi-polarity steep pulse generator for tissue ablation includes an energy storage device 1, a switch 2, transmission lines 3, 36, 37, and 38, and loads 46, 47, 48, and 49. The energy storage device 1 is a capacitor. The device is characterized in that one end of the energy storage device 1 is connected to the inner conductor 4 of the input terminal of transmission line 3 via the switch 2, and the other end of the energy storage device 1 is connected to the inner conductor 43 of the input terminal of transmission line 38; the outer conductor 7 of the input terminal of transmission line 3 is connected to the outer conductor 40 of the input terminal of transmission line 36; the outer conductor 42 of the input terminal of transmission line 37 is connected to the outer conductor 44 of the input terminal of transmission line 38; and the inner conductor 39 of the input terminal of transmission line 36 is connected to the inner conductor 41 of the input terminal of transmission line 37. The outer conductors 13, 51, and 53 of the output terminals of transmission lines 3, 3, and 38 are connected together, and the outer conductor 55 of the output terminal of transmission line 38 is connected together and then connected to ground 45. Load 46 is connected to the inner conductor 11 and outer conductor 13 of the output terminal of transmission line 3, respectively, and outputs a high-voltage pulse with an amplitude of +1 / 4 of the voltage V on energy storage device 1. Load 47 is connected to the inner conductor 50 and outer conductor 51 of the output terminal of transmission line 36, respectively, and outputs a high-voltage pulse with an amplitude of -1 / 4 of the voltage V on energy storage device 1. Load 48 is connected to the inner conductor 52 and outer conductor 53 of the output terminal of transmission line 37, respectively, and outputs a high-voltage pulse with an amplitude of +1 / 4 of the voltage V on energy storage device 1. Load 49 is connected to the inner conductor 54 and outer conductor 55 of the output terminal of transmission line 38, respectively, and outputs a high-voltage pulse with an amplitude of -1 / 4 of the voltage V on energy storage device 1.

[0049] Example 9

[0050] like Figure 10 As shown, a multi-channel, multi-polarity steep pulse generator for tissue ablation includes an energy storage device 1, a switch 2, a transmission line 3, a transmission line 5, a liver 58, an intrahepatic tumor 59, electrode needles 60 and 61. Electrode needles 60 and 61 have insulating layers and discharge tips, and are parallel to each other. The energy storage device 1 has one end connected to the inner conductor 4 of the input end of the transmission line 3 via the switch 2, and the other end connected to the inner conductor 6 of the input end of the transmission line 5. The outer conductor 7 of the input end of the transmission line 3 is connected to the outer conductor 8 of the input end of the transmission line 5, and is connected to ground 9. The inner conductor 11 of the output end of the transmission line 3 and the inner conductor 12 of the output end of the transmission line 5 are respectively connected to electrode needles 60 and 61, which are inserted into the liver 58. Figure 11 As shown, the electric field's effective range 64 covers the intrahepatic tumor 59.

[0051] Example 9

[0052] As shown in Figure 12 A multi-channel multi-polarity steep pulse generating device for tissue ablation, comprising an energy storage device 1, a switch 2, a transmission line 3, a transmission line 5, a liver 58, an intrahepatic tumor 59, an electrode needle 60, an electrode needle 61, an electrode needle 62, an electrode needle 63, the electrode needles 60, 61, 62, 63 are provided with an insulating layer and a discharge front end, and the electrode needles 60, 61, 62, 63 are parallel to each other. Its characteristics are that one end of the energy storage device 1 is connected to the inner conductor 4 of the input end of the transmission line 3 through the switch 2, the other end of the energy storage device 1 is connected to the inner conductor 6 of the input end of the transmission line 5, the outer conductor 7 of the input end of the transmission line 3 is connected to the outer conductor 8 of the input end of the transmission line 5, and is connected to the ground 9. The inner conductor 11 of the output end of the transmission line 3 and the inner conductor 12 of the output end of the transmission line 5 are respectively connected to the electrode needle 60 and the electrode needle 61, the outer conductor 13 of the output end of the transmission line 3 and the outer conductor 14 of the output end of the transmission line 5 are respectively connected to the electrode needle 62 and the electrode needle 63, and the electrode needles 60, 61, 62, 63 are inserted into the liver 58. As shown in Figure 13 The electric field action range 64 covers the intrahepatic tumor 59.

[0053] Example 11

[0054] As shown in Figure 14 A multi-channel multi-polarity steep pulse generating device for tissue ablation, comprising an energy storage device 1, a switch 2, a transmission line 3, a transmission line 5, a liver 58, an intrahepatic tumor 59, an electrode needle 60, an electrode needle 61, an electrode needle 62, an electrode needle 63, the electrode needles 60, 61, 62, 63 are provided with an insulating layer and a discharge front end, and the electrode needles 60, 61, 62, 63 are parallel to each other. Its characteristics are that one end of the energy storage device 1 is connected to the inner conductor 4 of the input end of the transmission line 3 through the switch 2, the other end of the energy storage device 1 is connected to the inner conductor 6 of the input end of the transmission line 5, the outer conductor 7 of the input end of the transmission line 3 is connected to the outer conductor 8 of the input end of the transmission line 5, and is connected to the ground 9. The inner conductor 11 of the output end of the transmission line 3 and the inner conductor 12 of the output end of the transmission line 5 are respectively connected to the electrode needle 60 and the electrode needle 61, the outer conductor 13 of the output end of the transmission line 3 and the outer conductor 14 of the output end of the transmission line 5 are respectively connected to the electrode needle 62 and the electrode needle 63, and the electrode needles 60, 61, 62, 63 are inserted into the liver 58. As shown in Figure 15 The electric field action range 64 covers the intrahepatic tumor 59. According to the layout of the electrode needle position, irregular shape tissue ablation can be realized, and through the arrangement of the grounding electrode, the electric field shielding and protection of important tissue structures can be realized.

[0055] Example 12

[0056] As shown in Figure 16As shown, a multi-channel, multi-polar steep pulse generator for tissue ablation includes an energy storage device 65, a switch 2, a transmission line 3, a transmission line 5, and a load 10. The energy storage device 65 is a pulse forming line. The device is characterized in that one end of the energy storage device 65 is connected to the inner conductor 4 of the input terminal of the transmission line 3 via the switch 2, and the other end of the energy storage device 65 is connected to the inner conductor 6 of the input terminal of the transmission line 5. The outer conductor 7 of the input terminal of the transmission line 3 is connected to the outer conductor 8 of the input terminal of the transmission line 5, and is connected to ground 9. The two ends of the load 10 are respectively connected to the inner conductor 11 of the output terminal of the transmission line 3 and the inner conductor 12 of the output terminal of the transmission line 5, and the outer conductor 13 of the output terminal of the transmission line 3 and the outer conductor 14 of the output terminal of the transmission line 5. A unipolar pulse is output on the load 10, but the potential polarities at the two ends of the load are opposite, and the amplitude of each pulse is half of the voltage V on the energy storage device 65.

[0057] Example 13

[0058] like Figure 17 As shown, a multi-channel, multi-polar steep pulse generator for tissue ablation includes an energy storage device 66, a switch 2, a transmission line 3, a transmission line 5, and a load 10. The energy storage device 66 is an artificially formed wire. The device is characterized in that one end of the energy storage device 66 is connected to the inner conductor 4 of the input end of the transmission line 3 via the switch 2, and the other end of the energy storage device 66 is connected to the inner conductor 6 of the input end of the transmission line 5. The outer conductor 7 of the input end of the transmission line 3 is connected to the outer conductor 8 of the input end of the transmission line 5, and is connected to ground 9. The two ends of the load 10 are respectively connected to the inner conductor 11 of the output end of the transmission line 3 and the inner conductor 12 of the output end of the transmission line 5, and the outer conductor 13 of the output end of the transmission line 3 and the outer conductor 14 of the output end of the transmission line 5. A unipolar pulse is output on the load 10, but the potential polarities at the two ends of the load are opposite, and the amplitude of each pulse is half of the voltage V on the energy storage device 66.

[0059] Example 14

[0060] like Figure 18As shown, a multi-channel, multi-polarity steep pulse generator for tissue ablation includes an energy storage device 1, a switch 2, a switch 67, transmission lines 3, 36, 37, and 38, a load 56, and a load 57. The energy storage device 1 is a capacitor. The device is characterized in that one end of the energy storage device 1 is connected to the inner conductor 4 of the input end of the transmission line 3 via the switch 2, and the other end of the energy storage device 1 is connected to the inner conductor 43 of the input end of the transmission line 38 via the switch 67; the outer conductors 7, 40, 42, and 44 of the input ends of the transmission lines 3, 3, 37, and 38 are connected together and then connected to ground 45; the inner conductor 4 of the input end of the transmission line 3 is connected to the inner conductor 39 of the input end of the transmission line 36; and the inner conductor 41 of the input end of the transmission line 37 is connected to the inner conductor 43 of the input end of the transmission line 38. The outer conductors 13, 51, 53, and 55 of the output terminals of transmission line 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 4, 3, 3, 4, 5, and 5, respectively, are connected together. The two ends of load 56 are connected to the inner conductors 11 and 54 of the output terminals of transmission line 3 and 38, respectively, outputting a high-voltage pulse with an amplitude equal to the voltage V on energy storage device 1. The potentials of the inner conductors 11 and 54 of the output terminals of transmission line 3 and 38 are +V / 2 and -V / 2, respectively. The two ends of load 57 are connected to the inner conductors 50 and 52 of the output terminals of transmission line 36 and 37, respectively, outputting a high-voltage pulse with an amplitude equal to the voltage V on energy storage device 1. The potentials of the inner conductors 50 and 52 of the output terminals of transmission line 36 and 37 are +V / 2 and -V / 2, respectively. Compared with Example 6, the feature is that the operating voltage of switch 2 and switch 67 is halved, and the insulation strength requirement between the two ends of energy storage device 1 and ground is halved.

[0061] Example 15

[0062] like Figure 19 As shown, a multi-channel, multi-polar steep pulse generator for tissue ablation includes an energy storage device 68, a transmission line 3, a transmission line 5, and a load 10. The energy storage device 68 is a Blumelin pulse forming line. The device is characterized in that one end of the energy storage device 68 is connected to the inner conductor 4 of the input terminal of the transmission line 3, and the other end of the energy storage device 68 is connected to the inner conductor 6 of the input terminal of the transmission line 5. The outer conductor 7 of the input terminal of the transmission line 3 is connected to the outer conductor 8 of the input terminal of the transmission line 5, and is also connected to ground 9. The two ends of the load 10 are connected to the inner conductor 11 of the output terminal of the transmission line 3 and the inner conductor 12 of the output terminal of the transmission line 5, respectively. The outer conductor 13 of the output terminal of the transmission line 3 and the outer conductor 14 of the output terminal of the transmission line 5 are also connected. A unipolar pulse is output on the load 10, but the potential polarities at both ends of the load are opposite, and the amplitude of each pulse is half of the voltage V on the energy storage device 68.

[0063] The above-described specific embodiments further illustrate the objects, technical solutions and advantages of the present application. It should be understood that the above-described specific embodiments are merely for the purpose of illustrating the present application and are not intended to limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A synchronized multi-channel multi-polarity steep pulse generator for tissue ablation, comprising energy storage device, switch, load, transmission line, characterized in that: One end of the energy storage device is connected to the inner conductor of the first transmission line input end through a switch, and the other end of the energy storage device is connected to the outer conductor of the third transmission line input end; the outer conductor of the first transmission line input end is connected to the outer conductor of the second transmission line input end; the inner conductor of the second transmission line input end is connected to the inner conductor of the third transmission line input end; the two ends of the first load are respectively connected to the inner conductor of the first transmission line output end and the inner conductor of the second transmission line output end, and a high-voltage pulse with an amplitude of 2 / 3 of the voltage V on the energy storage device is output on the first load; the two ends of the second load are respectively connected to the inner conductor of the second transmission line output end and the inner conductor of the third transmission line output end, and a high-voltage pulse with an amplitude of 2 / 3 of the voltage V on the energy storage device is output on the second load; the outer conductors of the first transmission line output end, the second transmission line output end and the third transmission line output end are connected together and then connected to the ground; the potentials of the inner conductors of the first transmission line output end, the second transmission line output end and the third transmission line output end are +V / 3, -V / 3 and +V / 3 respectively.

2. The synchronized multiplexed multi-polarity sharp pulse generator of claim 1, wherein: The switch comprises a spark gap switch, a magnetic switch and a semiconductor switch.

3. The synchronized multiplexed multi-polarity sharp pulse generator of claim 1, wherein: The energy storage device comprises a capacitor, a pulse forming line, an artificial forming line and a Blumlein pulse forming line.

4. The synchronized multiplexed multi-polarity sharp pulse generator of claim 1, wherein: The load comprises biological tissues, tumors, cells and microorganisms.

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