Monitoring system and oxygen measurement system

Abstract

A monitoring system (16) that constitutes an oxygen measurement system (12) includes an oxygen partial pressure calculation section (120) that calculates an oxygen partial pressure in urine based on an output signal from an oxygen measurement device (10A), a monitor (114) that can display the oxygen partial pressure calculated by the oxygen partial pressure calculation section (120), and a display control section (130) that changes a display form of the oxygen partial pressure displayed on the monitor (114) in accordance with a flow rate of the urine obtained based on the output signal from the oxygen measurement device (10A).

Description

[0001] The present application is a divisional application of an application for an invention, which is an international application No. PCT / JP2018 / 009546 filed on March 12, 2018, entered the National Phase in China as a National Application No. 201880022822.6, and has an invention name of "Monitoring system and oxygen measurement system". TECHNICAL FIELD

[0002] The present application relates to a monitoring system and an oxygen measurement system provided with a urethral catheter. BACKGROUND

[0003] For example, in Japanese Patent No. 2739880, an oxygen measurement device is disclosed, which inserts an oxygen sensor into a bladder through a urinary tract of a urethral catheter and is left. The oxygen measurement device detects and monitors oxygen partial pressure of an epithelial wall by causing an oxygen sensor main body of the oxygen sensor to be guided from a urethral opening formed in a front end portion of the urethral catheter and to be in contact with the epithelial wall of the bladder. SUMMARY

[0004] In addition, a study is being made in which it is assumed that oxygen conditions in urine reflect tissue oxygen conditions of a kidney, and a state of the kidney is predicted by measuring oxygen partial pressure in the urine. In the case of predicting such a state of the kidney, it is important to measure oxygen partial pressure in urine that has been discharged from the kidney shortly, i.e., urine that is flowing stably. However, if only the oxygen partial pressure in the urine is measured and monitored, there is a concern that it is not easy to know whether the measured oxygen partial pressure is oxygen partial pressure in urine that is flowing stably.

[0005] The present application is made in consideration of such a problem, and an object thereof is to provide a monitoring system and an oxygen measurement system in which it is easy to know whether measured oxygen partial pressure is oxygen partial pressure in urine that is flowing stably and properly reflects a state of a kidney.

[0006] In order to achieve the above object, the monitoring system of the present application is a monitoring system that can be connected to an oxygen measurement device provided with a sensor for calculating oxygen partial pressure in urine and a flow rate of the urine, characterized by comprising: an oxygen partial pressure calculation portion that calculates oxygen partial pressure in the urine based on an output signal from the oxygen measurement device; a flow rate calculation portion that calculates the flow rate of the urine based on the output signal from the oxygen measurement device; and a display control portion that changes a display form of the oxygen partial pressure in accordance with the calculated flow rate of the urine when the calculated oxygen partial pressure is displayed on a monitor.

[0007] According to such a configuration, by observing the display form of the oxygen partial pressure displayed on the monitor, it is easy to know whether the measured oxygen partial pressure is oxygen partial pressure in urine that is flowing stably and properly reflects a state of a kidney.

[0008] In the above monitoring system, it can also be that a flow rate determination section that determines whether the flow rate of urine obtained based on the output signal from the oxygen measurement device is equal to or greater than a prescribed value is provided, and the display control section displays the oxygen partial pressure on the monitor in the first display form when the flow rate of urine is determined by the flow rate determination section to be equal to or greater than the prescribed value, and displays the oxygen partial pressure on the monitor in the second display form different from the first display form when the flow rate of urine is determined by the flow rate determination section to be less than the prescribed value.

[0009] According to such a configuration, in a case where the oxygen partial pressure is displayed on the monitor in the first display form, it can be easily known that the measured oxygen partial pressure is the oxygen partial pressure in urine flowing at a flow rate equal to or greater than the prescribed value. Also, in a case where the oxygen partial pressure is displayed on the monitor in the second display form, it can be easily known that the measured oxygen partial pressure is the oxygen partial pressure in urine flowing at a flow rate less than the prescribed value. Thus, it can be easily known whether the oxygen partial pressure is obtained in a state in which the kidney state is properly reflected.

[0010] In the above monitoring system, it can also be that a flow rate determination section that determines whether the flow rate of urine obtained based on the output signal from the oxygen measurement device is equal to or greater than a prescribed value is provided, and the display control section displays the oxygen partial pressure on the monitor in the first display form when the flow rate of urine is determined by the flow rate determination section to be equal to or greater than the prescribed value, and displays the oxygen partial pressure on the monitor in the second display form different from the first display form when the flow rate of urine is determined by the flow rate determination section to be less than the prescribed value.

[0011] According to such a configuration, in a case where the oxygen partial pressure is displayed on the monitor in the first display form, it can be easily known that the measured oxygen partial pressure is the oxygen partial pressure in urine flowing at a flow rate equal to or greater than the prescribed value. Also, in a case where the oxygen partial pressure is displayed on the monitor in the second display form, it can be easily known that the measured oxygen partial pressure is the oxygen partial pressure in urine flowing at a flow rate less than the prescribed value. Thus, it can be easily known whether the oxygen partial pressure is obtained in a state in which the kidney state is properly reflected.

[0012] In the above monitoring system, it can also be that the display control section displays a graph showing the temporal change in oxygen partial pressure on the monitor.

[0013] According to such a configuration, it can be easily known that the oxygen partial pressure in urine changes over time. Thus, it can be easily known whether the kidney state is good or not compared to before, and thus it is possible to perform an intervention such as treatment or adjustment of the same at an appropriate timing as needed.

[0014] In the above monitoring system, it can also be that the oxygen partial pressure calculation section calculates the oxygen partial pressure in urine that is corrected based on the temperature in urine obtained based on the output signal from the oxygen measurement device.

[0015] According to such a configuration, it is possible to display the oxygen partial pressure in urine that is corrected for temperature with higher accuracy on the monitor.

[0016] In the above monitoring system, it can also be provided with: a urine amount calculation section that calculates the amount of urine based on the output signal from the oxygen measurement device; and a urine amount determination section that determines whether the amount of urine calculated by the urine amount calculation section meets a prescribed urine amount condition, the display control section causing the main display to be displayed on the monitor in a case where the amount of urine is determined by the urine amount determination section to meet the urine amount condition.

[0017] According to such a configuration, it is possible to easily know whether the amount of urine meets the prescribed urine amount condition (e.g., whether the amount of urine is in a state of being too little). Thus, it is possible to easily know whether the kidney state is good compared to before, and thus it is possible to intervene in treatment or adjustment thereof, etc. at an appropriate timing as needed.

[0018] The oxygen measurement system of the present application is characterized by being provided with: a urethral catheter having a urinary tract through which urine flows; an oxygen sensor that is capable of outputting a signal used to calculate the oxygen partial pressure in urine flowing in the urethral catheter; a flow rate sensor that is capable of outputting a signal used to calculate the flow rate of urine flowing in the urethral catheter; an oxygen partial pressure calculation section that calculates the oxygen partial pressure in urine based on the output signal output from the oxygen sensor; a flow rate calculation section that calculates the flow rate of urine based on the output signal output from the flow rate sensor; and a display control section that changes the display form of the oxygen partial pressure displayed on the monitor in accordance with the flow rate of urine calculated by the flow rate calculation section.

[0019] According to such a configuration, it is possible to obtain an oxygen measurement system that has the same effect as the above monitoring system.

[0020] According to the present application, since the display form of the oxygen partial pressure displayed on the monitor is changed in accordance with the flow rate of urine acquired based on the output signal from the oxygen measurement device, by observing the display form of the oxygen partial pressure displayed on the monitor, it is possible to easily know whether the measured oxygen partial pressure is the oxygen partial pressure in urine that is flowing stably. Thus, it is possible to easily know whether it is an oxygen partial pressure acquired in a state where the kidney state is being properly reflected. In addition, it is possible to easily know whether the kidney state is good compared to before, and thus it is possible to intervene in treatment or adjustment thereof, etc. at an appropriate timing as needed. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 is a schematic view showing the outline configuration of an oxygen measurement system provided with an oxygen measurement device according to one embodiment of the present application.

[0022] Figure 2 is Figure 1 is a partial, cross-sectional view of the oxygen measurement device shown in

[0023] Figure 3 is a partial, cross-sectional view of the oxygen measurement device shown in Figure 2is a partial omitted longitudinal sectional view of the III-III line.

[0024] Figure 4 is Figure 2 is a perspective view of the blocking portion and the oxygen sensor main body.

[0025] Figure 5 is a cross-sectional view along the V-V line. Figure 3

[0026] Figure 6 is a block diagram illustrating the monitor main body portion. Figure 1

[0027] is a schematic view illustrating a method of using the oxygen measurement system. Figure 7

[0028] is a first flowchart illustrating a method of using the oxygen measurement system. Figure 8

[0029] is a second flowchart illustrating a method of using the oxygen measurement system. Figure 9

[0030] is a first graph showing a measurement result of the oxygen measurement system displayed on a monitor. Figure 10

[0031] in Fig. 11, Figure 11A is a second graph showing a measurement result of the oxygen measurement system displayed on a monitor, Figure 11B is a third graph showing a measurement result of the oxygen measurement system displayed on a monitor.

[0032] Figure 12 is a cross-sectional view showing a modification of the oxygen measurement apparatus. DETAILED DESCRIPTION

[0033] Hereinafter, regarding the monitoring system of the present application, embodiments preferred in accordance with the relationship with the oxygen measurement system will be described with reference to the accompanying drawings. Figure 1

[0034] The oxygen measurement system 12 of one embodiment of the present application is a system for measuring the oxygen partial pressure (oxygen concentration) in the urine discharged from the kidney into the urinary bladder 140 in order to predict the state of the kidney.

[0035] As Figure 1 shown in Fig. 1, the oxygen measurement system 12 is provided with an oxygen measurement apparatus 10A having a urethral catheter 18, a urine storage bag 14 (urine storage container), and a monitoring system 16. In addition, in the following description, the right side of the urethral catheter 18 in Fig. 1 will be referred to as the "proximal end side", and the left side of the urethral catheter 18 will be referred to as the "distal end side", and the same applies to other drawings. Figure 2 ​​​​

[0036] As shown in Figure 1 and Figure 2 , the oxygen measurement apparatus 10A is provided with a urethral catheter 18 and an oxygen sensor 20. The urethral catheter 18 is a medical apparatus that is left in a living body at the time of use and used to discharge urine in a urinary bladder 140 to a urine storage bag 14 arranged outside the body. The urethral catheter 18 is provided with a hollow shaft 22 having flexibility, a stopper 23 (a tip cap) provided at the most distal end of the shaft 22, a balloon 24 provided at the distal end portion of the shaft 22, and a hub 26 provided at the base end portion of the shaft 22.

[0037] The shaft 22 is a tube of a thin diameter and a long dimension. The shaft 22 has appropriate flexibility and appropriate rigidity so as to be able to pass through the urethra 144 to smoothly insert the distal end portion of the urethral catheter 18 into the urinary bladder 140. As a material constituting the shaft 22, for example, rubber such as silicone rubber or latex rubber, other elastomers, vinyl chloride, polyurethane, a plastic tube, or the like can be listed.

[0038] As shown in Figure 2 and Figure 3 , on the shaft 22, two urethral openings 28 that make urine in the urinary bladder 140 flow into the shaft 22, a lumen 30 that communicates with the urethral openings 28 and extends in the entire length range of the shaft 22, and a dilatation lumen 32 for making a dilatation fluid of the balloon 24 circulate are formed.

[0039] Each of the urethral openings 28 is opened at a portion of the outer peripheral surface of the shaft 22 on the distal end side from the balloon 24. The two urethral openings 28 are provided at positions opposite to each other. The urethral opening 28 is an elongated hole extending in the length direction of the shaft 22. Specifically, the urethral opening 28 is formed in a shape in which each of the short sides of a rectangular shape protrudes outward in a circular arc shape (a shape close to an ellipse) (see Figure 2 ). The shape, size, position, and number of the urethral opening 28 can be arbitrarily set.

[0040] On the distal end surface of the shaft 22, a distal end opening portion 34 of the lumen 30 is formed. The distal end opening portion 34 of the lumen 30 is occluded by the stopper 23. The stopper 23 is constituted of the same material as the shaft 22. As shown in Figure 2 , Figure 3 and Figure 5 , the stopper 23 has a distal end bulging portion 36 bulging toward the distal end side compared to the shaft 22, and a protruding portion 38 protruding toward the base end direction from a base end surface 36a (see Figure 4 ) of the distal end bulging portion 36 and fitting with the distal end opening portion 34 of the lumen 30 in a liquid-tight manner. The outer surface of the distal end bulging portion 36 is constituted of a partial curved surface of a rotational ellipsoid. The base end surface 36a of the distal end bulging portion 36 is formed flat. The protruding portion 38 is formed in a rectangular parallelepiped shape.

[0041] In Figure 2 and Figure 3In this configuration, the sealing portion 23 is fixed relative to the shaft 22 by an adhesive 40. The adhesive 40 is injected between the base end face 36a of the front bulge 36 and the front end face of the shaft 22, and between the protrusion 38 and the wall surface of the front opening 34 constituting the inner cavity 30. Furthermore, the adhesive 40 seals the front end of the expansion tube 32. On the two side surfaces 38b of the protrusion 38 located on both sides of the protrusion end face 38a in the height direction (width direction), locking grooves 41 are formed over the entire width (see reference). Figure 4 ).

[0042] The portion of the inner cavity 30 of shaft 22 closer to the base end than the sealing portion 23 functions as a urinary catheter 42. The urinary catheter 42 is positioned such that the axis Ax of shaft 22 is located within the urinary catheter. The cross-section of the urinary catheter 42 is quadrilateral (see reference). Figure 5 However, the cross-section of the catheter 42 can be of any shape.

[0043] like Figure 3 As shown, a temperature sensor 44 is embedded in the wall of shaft 22. The temperature sensor 44 includes: a temperature sensor body 46 (temperature probe) for detecting the temperature within the bladder 140; and a temperature transmission section 48 electrically connected to the temperature sensor body 46. The temperature sensor body 46 is positioned at the same location as the catheter port 28 along the axial direction of shaft 22. The temperature sensor body 46 includes a thermocouple, a temperature-sensing resistor, or a thermistor. The temperature sensor 44 is capable of detecting the temperature of urine within the bladder 140. Alternatively, the temperature sensor body 46 may be positioned offset from the catheter port 28 towards the front end or base end along the axial direction of shaft 22. Furthermore, the temperature sensor body 46 may also be disposed within the catheter lumen 42. In this case, the temperature of urine flowing within the urinary tract 74 can be detected with high precision.

[0044] An oxygen sensor 20 is provided inside the urinary catheter 42. The oxygen sensor 20 is configured as a fluorescent (optical) oxygen sensor 20, having: an oxygen sensor body 50 capable of detecting oxygen in urine; and an oxygen delivery unit 52 (optical fiber 58) separately disposed from the oxygen sensor body 50 and arranged inside the urinary catheter 42. The oxygen sensor 20 is fixed to the urethral catheter 18 in such a way that the oxygen sensor body 50 is in contact with the urine flowing in the urinary catheter 42.

[0045] The oxygen sensor body 50 has a substrate 54 (base) and a phosphor 56 coated on one side of the substrate 54, substantially entirely. The substrate 54 is made of a material capable of transmitting excitation light from an optical fiber 58 and fluorescence from the phosphor 56. Such a substrate 54 is made of, for example, glass or polyethylene. The substrate 54 has the same width dimension as the protrusion 38 and is disposed on the protrusion 38 such that at least a portion of the phosphor 56 is located within the catheter lumen. Specifically, the substrate 54 covers the protruding end face 38a and two side faces 38b of the protrusion 38 in a generally U-shaped fold. The ends of the substrate 54 in the extending direction are folded to engage with the respective locking grooves 41.

[0046] The phosphor 56 is made of a material that emits fluorescence when exposed to excitation light from the optical fiber 58. Specifically, examples of materials constituting the phosphor 56 include platinum porphyrin, ruthenium complexes, and pyrene derivatives. A coating that blocks interfering light is applied to the phosphor 56. However, such a coating may not be applied to the phosphor 56.

[0047] The oxygen delivery unit 52 is an optical fiber 58, capable of irradiating excitation light onto the phosphor 56 and receiving fluorescence from the phosphor 56. It is fixed to the urethral catheter 18 with the front end face 58a of the optical fiber 58 positioned relative to the phosphor 56. The optical fiber 58 can be made of glass or plastic. The optical fiber 58 is fixed to the shaft 22 via the fixing part 60 with its exposed front end face 58a facing the phosphor 56 away from the ground.

[0048] The fixing part 60 includes: an optical fiber support part 64, which is provided on the wall surface constituting the urinary catheter 42 and has an insertion hole 62 for inserting the tip of the optical fiber 58; and an adhesive 66, which fixes the optical fiber 58 to the wall surface constituting the urinary catheter 42. The adhesive 66 seals the through hole 68 formed on the outer surface of the shaft 22. The adhesive 66 is made of a material that allows light from the optical fiber 58 and fluorescence from the phosphor 56 to be transmitted. Therefore, even when the adhesive 66 enters between the tip face 58a of the optical fiber 58 and the substrate 54, the excitation light from the optical fiber 58 can still irradiate the phosphor 56 and receive the fluorescence from the phosphor 56 through the optical fiber 58. In the axial direction of the shaft 22, the position of the tip face 58a of the optical fiber 58 is approximately the same as the position of the end in the front direction of the urinary port 28.

[0049] The balloon 24 can expand and contract according to changes in internal pressure. That is, the balloon 24 expands by introducing expansion fluid into it and contracts by draining the expansion fluid from it. Furthermore, in Figure 1 The balloon 24 in its expanded state is shown in the image.

[0050] The hub 26 is integrally formed into a hollow shape using the same material or resin material as the shaft 22. The hub 26 has a urination port 70 communicating with the urination lumen 42 and a balloon dilation port 72 communicating with the dilation lumen 32. The urination lumen 42 and the urination port 70 constitute the urinary passage 74 of the urethral catheter 18, serving as a urine discharge path. A flow rate sensor 76 is provided on the wall forming the urination port 70, capable of detecting the flow rate of urine flowing through the urination port 70. That is, the flow rate sensor 76 is provided in contact with the urine flowing within the urination port 70, or is provided near the wall. The balloon dilation port 72 is configured to connect to a pressure application device (not shown) for pressurizing dilation fluid into the balloon 24 via the dilation lumen 32. Furthermore, the balloon dilation port 72 includes a valve (not shown) that opens when the pressure application device is connected and closes when disconnected. The hub 26 is configured to be detached from the cable connector 90 of the monitoring system 16.

[0051] like Figure 1 As shown, the urine collection bag 14 is configured as a so-called closed bag, having a bag body 78, a catheter 80 for introducing urine from the urethral catheter 18 into the bag body 78, and a draining part 82 for draining urine from the bag body 78. Such a urine collection bag 14 is integrally constructed using a resin material or the like. However, the urine collection bag 14 can also be a detachable bag.

[0052] like Figure 1 and Figure 2 As shown, the monitoring system 16 includes: a cable connector 90 detachable from the hub 26; a long transmission cable 92 connected to the cable connector 90; and a monitor body 94 connected to the transmission cable 92. The cable connector 90 is provided with an oxygen cable 96 optically connected to the oxygen transmission unit 52, a temperature cable 98 electrically connected to the temperature transmission unit 48, and a flow rate cable 100 electrically connected to the flow rate sensor 76. The oxygen cable 96 is an optical fiber, while the temperature cable 98 and flow rate cable 100 are electrical wires. The oxygen cable 96, temperature cable 98, and flow rate cable 100 are combined into a single cable via the transmission cable 92 and extend to the monitor body 94.

[0053] The delivery cable 92 is arranged along the catheter 80 and is secured relative to the catheter 80 by multiple locking components 102 (bundles). This prevents the catheter 80 and delivery cable 92 from becoming an obstruction when using the oxygen measurement device 10A.

[0054] like Figure 6 As shown, the main body 94 of the monitor includes a light-emitting unit 104, a light-receiving unit 106, an A / D converter 108, a start button 110, a stop button 112, a monitor 114, and a control unit 116.

[0055] The light emitting section 104 is, for example, a light emitting diode, and emits excitation light of a prescribed wavelength toward the oxygen cable 96. The light receiving section 106 is, for example, a photodiode, and receives fluorescent light transmitted from the oxygen cable 96. The A / D converter 108 converts a light receiving signal of the light receiving section 106 into a digital value and outputs to the control section 116.

[0056] The start button 110 is a button for starting the measurement of the oxygen partial pressure in urine. The stop button 112 is a button for stopping the measurement of the oxygen partial pressure in urine. In addition, a power button and the like, not shown, are also provided on the monitor main body section 94.

[0057] The monitor 114 is configured to be able to display the oxygen partial pressure in urine calculated by the control section 116. The monitor 114 is a so-called full dot liquid crystal type display, and is able to display prescribed information in color. The monitor 114 has a touch panel function, and also functions as an input section for inputting prescribed information. The input form based on the monitor 114 can be a pointing device other than the touch panel type, such as a mouse cursor type, a stylus type, a touch pad type, and the like. Furthermore, the input of information with respect to the monitor main body section 94 is not limited to the input based on the monitor 114, and can be input by an input button or the like.

[0058] The control section 116 has a storage section 118 and various function implementing sections. Furthermore, the function implementing section is a software function section that implements a function by a CPU (Central Processing Unit) executing a program stored in the storage section 118, but can also be implemented by a hardware function section constituted by an integrated circuit such as an FPGA (Field-Programmable Gate Array). The storage section 118 has a nonvolatile memory (for example, a flash memory) that can be written, and is able to store information input via the monitor 114 and information calculated by the control section 116, and the like.

[0059] The control section 116 has the storage section 118, an oxygen partial pressure calculating section 120, a urine volume calculating section 122, a flow rate calculating section 123, a flow rate determining section 124, a urine volume condition setting section 126, a urine volume determining section 128, and a display control section 130. In addition, the control section 116 has a temperature input section, not shown, that inputs an output signal of the temperature sensor 44, and a flow rate input section, not shown, that inputs an output signal of the flow rate sensor 76.

[0060] The oxygen partial pressure calculating section 120 calculates the oxygen partial pressure in urine based on the output signal of the oxygen sensor 20 and the output signal of the temperature sensor 44. The urine volume calculating section 122 calculates the urine volume based on the output signal of the flow rate sensor 76. The flow rate calculating section 123 calculates the flow rate V of urine in the urinary tract 74 based on the output signal from the flow rate sensor 76.

[0061] The urine amount condition setting section 126 sets a prescribed urine amount condition. Specifically, the urine amount condition setting section 126 sets a first urine amount determination value and a second urine amount determination value. The first urine amount determination value is calculated, for example, by multiplying a first urine amount reference value (0.5 ml / kg / h) used in determination of a first stage and a second stage of acute kidney injury (AKI) by the weight of the patient. The second urine amount determination value is calculated by multiplying a second urine amount reference value (0.3 ml / kg / h) used in determination of a third stage of acute kidney injury by the weight of the patient. However, the urine amount condition setting section 126 can set an arbitrary condition. The urine amount determination section 128 determines whether the urine amount calculated by the urine amount calculation section 122 meets the prescribed urine amount condition.

[0062] The display control section 130 changes the display form of the oxygen partial pressure displayed on the monitor 114 in accordance with the flow rate V of urine obtained based on the output signal of the flow rate sensor 76. Specifically, the display control section 130 causes the oxygen partial pressure to be displayed on the monitor 114 in a first display form in a case where it is determined by the flow rate determination section 124 that the flow rate V of urine is a prescribed value or more (a reference flow rate V0 or more), and causes the oxygen partial pressure to be displayed on the monitor 114 in a second display form different from the first display form in a case where it is determined by the flow rate determination section 124 that the flow rate V of urine is less than the prescribed value (less than the reference flow rate V0). The display control section 130 causes a graph showing the temporal change of the oxygen partial pressure to be displayed on the monitor 114. The display control section 130 causes the gist to be displayed on the monitor 114 in a case where it is determined by the urine amount determination section 128 that the urine amount meets the urine amount condition.

[0063] Next, the assembly of the oxygen sensor 20 with respect to the urethral catheter 18 will be described. In the present embodiment, the optical fiber 58 is disposed inside the catheter tube 42 with its front end inserted into the insertion hole 62 of the optical fiber support section 64. Further, the optical fiber 58 is fixed with respect to the shaft 22 by injecting the adhesive 66 from the outside of the shaft 22 through the penetration hole 68. In addition, the both end portions of the oxygen sensor main body 50 are engaged with the respective engagement grooves 41 of the protruding portions 38 in a state where the oxygen sensor main body 50 is bent in a U shape. Further, the plug portion 23 holding the oxygen sensor main body 50 is fitted to the front end opening portion 34 of the shaft 22 in a state where the front end face of the shaft 22 and the wall surface constituting the front end opening portion 34 are coated with the adhesive 66. Thereby, the plug portion 23 is fixed with respect to the shaft 22, and the oxygen sensor main body 50 is fixed with respect to the shaft 22. Thereby, the front end face 58a of the phosphor 56 and the optical fiber 58 can be positioned with high accuracy.

[0064] Next, the use of the oxygen measurement apparatus 10A will be described.

[0065] As shown in FIG. 1, first, a preparation process (S1) is performed. Figure 7 and Figure 8 As shown in FIG. 1, first, a preparation process (S1) is performed. Figure 8The procedure is the same as that of step S1). In the preparation procedure, the front end portion of the urethral catheter 18 is left in the bladder 140. Specifically, the front end of the shaft 22 coated with a lubricating gel is inserted from the urethral orifice 142 to the urethra 144 of the patient, and the catheterization port 28 and the balloon 24 are disposed in the bladder 140. Further, the shaft 22 can be easily inserted into the bladder 140 by imparting sufficient rigidity to the shaft 22 by inserting a stylet (not shown) into the catheterization lumen 42 of the shaft 22.

[0066] Then, the balloon 24 is expanded by pressure-feeding the expansion fluid from the expansion port to the expansion lumen 32 (refer to Figure 2 ) by a pressure-feeding device (not shown). Thereby, the urethral catheter 18 is prevented from being detached from the body, and the portion of the shaft 22 on the front end side of the balloon 24 is left in the bladder 140. Further, Figure 7 The reference numeral 146 in FIG. 1 is a pubic bone, the reference numeral 148 is a prostate, and the reference numeral 150 is an external urethral sphincter.

[0067] If the front end portion of the urethral catheter 18 is left in the bladder 140, the urine in the bladder 140 can be discharged to the urine storage bag 14 via the urethral catheter 18. At this time, in the urethral catheter 18, the urine in the bladder 140 flows from the catheterization port 28 to the urine lumen 74.

[0068] Further, the user inputs the body weight of the patient into the monitor main unit 94 (step S2). Thereby, the urine volume condition setting unit 126 calculates the first urine volume determination value and the second urine volume determination value based on the input body weight of the patient (step S3).

[0069] Then, the user operates the start button 110 (step S4). Thereby, the measurement of the oxygen partial pressure in the urine is started. The measurement of the oxygen partial pressure in the urine is continuously or intermittently (for example, every 5 minutes) performed until the stop button 112 is operated after the start button 110 is operated.

[0070] Specifically, the control unit 116 acquires various data (step S5). That is, the control unit 116 acquires the output signal of the temperature sensor 44 and the output signal of the flow rate sensor 76. In addition, the control unit 116 controls the light-emitting unit 104 to emit excitation light of a predetermined wavelength. As a result, the excitation light emitted from the light-emitting unit 104 is transmitted to the optical fiber 58 via the oxygen cable 96, and the phosphor 56 of the oxygen sensor body 50 is irradiated from the front end face 58a of the optical fiber 58. The phosphor 56 irradiated with excitation light transitions from the ground state to the excited state, emitting fluorescence while returning to the ground state. At this time, if oxygen molecules are present around the phosphor 56, the excitation energy will be taken away by the oxygen molecules due to interaction, and the intensity of fluorescence emission will decrease. This phenomenon is called extinction phenomenon, and the intensity of fluorescence emission is inversely proportional to the concentration of oxygen molecules. The fluorescence of the phosphor 56 is incident from the front end face 58a of the optical fiber 58 and guided to the light-receiving unit 106 via the optical fiber 58 and the oxygen cable 96. The light received by the light-receiving unit 106 is converted into a digital signal by the A / D converter 108 and input to the control unit 116. Thus, the output signal of the oxygen sensor 20 is acquired.

[0071] Then, the oxygen partial pressure calculation unit 120 calculates the oxygen partial pressure in the urine based on the output signal of the oxygen sensor 20 (output signal of the A / D converter 108) and the output signal of the temperature sensor 44 (step S6). Additionally, the flow rate determination unit 124 determines whether the urine flow rate V obtained based on the output signal of the flow rate sensor 76 is above a predetermined value (reference flow rate V0) (step S7). The reference flow rate V0 is pre-stored in the storage unit 118.

[0072] If the flow rate determination unit 124 determines that the flow rate V is greater than or equal to the reference flow rate V0 (step S7: Yes), the display control unit 130 sets the calculated oxygen partial pressure to be displayed on the monitor 114 in a first display format (step S8). On the other hand, if the flow rate determination unit 124 determines that the flow rate V is less than the reference flow rate V0 (step S7: No), the display control unit 130 sets the calculated oxygen partial pressure to be displayed on the monitor 114 in a second display format (step S9).

[0073] Next, urine volume determination and control are performed (step S10). In this urine volume determination and control (step S10), firstly, the urine volume calculation unit 122 calculates the urine volume and its cumulative value ( Figure 9 Step S20). That is, the urine volume calculation unit 122 calculates the urine volume based on the output signal of the flow rate sensor 76. The calculated urine volume is stored in the storage unit 118. Furthermore, the urine volume calculation unit 122 calculates the cumulative value of urine volume by adding the urine volume stored in the storage unit 118 to the urine volume calculated in this measurement. The cumulative value of urine volume is stored in the storage unit 118.

[0074] Then, the urine amount calculating section 122 calculates the urine amount per unit time (for example, per 1 hour) based on the cumulative value of the urine amount (step S21). Next, the urine amount determining section 128 determines whether the urine amount per unit time meets the urine amount condition (step S22).

[0075] Specifically, the urine amount determining section 128 determines which of the first to third stages of AKI is met. That is, the urine amount determining section 128 determines that the first stage is met in a case where the state in which the urine amount per unit time is less than the first urine amount determination value continues for 6 hours or more. In addition, the urine amount determining section 128 determines that the second stage is met in a case where the state in which the urine amount per unit time is less than the first urine amount determination value continues for 12 hours or more. Furthermore, the urine amount determining section 128 determines that the third stage is met in a case where the state in which the urine amount per unit time is less than the second urine amount determination value continues for 24 hours or more or the state in which there is no urine amount continues for 12 hours or more.

[0076] The display control section 130 is set to display the gist (the gist of the first to third stages) that meets the urine amount condition to the monitor 114 (step S23) in a case where the urine amount determining section 128 determines that any one of the first to third stages of AKI is met (step S22: Yes), and proceeds to the processing of step Sll of the Figure 8 On the other hand, the display control section 130 proceeds to the processing of step Sll of the Figure 8 in a case where the urine amount determining section 128 determines that none of the first to third stages of AKI is met (step S22: No).

[0077] Then, in step Sll, the display control section 130 causes various information to be displayed to the monitor 114. Specifically, as shown in Figure 10 , the display control section 130, for example, causes the oxygen partial pressure, the temperature in the bladder 140, the urine amount, the cumulative value of the urine amount to be displayed to the monitor 114 as numerical values and causes the time variation of the oxygen partial pressure and the time variation of the temperature in the bladder 140 to be displayed to the monitor 114 as a graph. In addition, the display control section 130 causes the gist to be displayed to the monitor 114 in a case where the urine amount determining control determines that any one of the first to third stages of AKI is met (step S22: Yes). Furthermore, the display control section 130 does not cause AKI to be displayed to the monitor 114 in a case where the urine amount determining control determines that none of the first to third stages of AKI is met (step S22: No).

[0078] In Figure 10In the example of FIG. 11, the oxygen partial pressure is shown as 38 mmHg, the temperature in the bladder 140 is shown as 37.4°C, the urine volume per unit time is shown as 25.1 mL / h, the cumulative urine volume is shown as 32 mL, and the AKI is shown as Stage 1. In addition, the time change in the oxygen partial pressure is shown in a bar chart, and the time change in the temperature in the bladder 140 is shown in a line graph. That is, the horizontal axis is time, one vertical axis is the oxygen partial pressure (mmHg), and the other vertical axis is the temperature (°C). In addition, in the bar chart, the portion that is colored is the portion in which the oxygen partial pressure is shown in the first display form, and the portion that is not colored is the portion in which the oxygen partial pressure is shown in the second display form. That is, in the bar chart, the oxygen partial pressure of the portion that is colored is the oxygen partial pressure in the urine when the flow rate V of the urine is equal to or greater than the reference flow rate Vo, and the oxygen partial pressure of the portion that is not colored is the oxygen partial pressure in the urine when the flow rate V of the urine is less than the reference flow rate Vo.

[0079] The first display form and the second display form of the oxygen partial pressure are not limited to those in the example of FIG. 11. For example, it is also possible to indicate the first display form in a state in which the bar chart is not colored, and to indicate the second display form in a state in which the bar chart is colored. Figure 10

[0080] In addition, as shown in FIG. 12, the display control section 130 can also cause the time change in the oxygen partial pressure to be displayed on the monitor 114 in a line graph. In this case, in the line graph, the thick line portion is the portion in which the oxygen partial pressure is displayed in the first display form, and the thin line portion is the portion in which the oxygen partial pressure is displayed in the second display form. However, it is also possible to indicate the first display form in a state in which the thin line is not colored, and to indicate the second display form in a state in which the thick line is colored. Figure 11A

[0081] Furthermore, as shown in FIG. 13, in the line graph, it is also possible to indicate the portion that is colored on the lower side of the line segment that shows the value of the oxygen partial pressure as the first display form of the oxygen partial pressure, and to indicate the portion that is not colored on the lower side as the second display form of the oxygen partial pressure. However, it is also possible to indicate the first display form in a state in which the lower side is not colored, and to indicate the second display form in a state in which the lower side is colored. Figure 11B

[0082] Then, the control section 116 determines whether or not the stop button 112 has been operated (Step S12). In the case in which the stop button 112 has not been operated (Step S12: No), the processing of Step S5 and the processing thereafter are performed. On the other hand, in the case in which the stop button 112 has been operated (Step S12: Yes), the control section 116 stops the operation of the oxygen measurement. That is, the excitation light of the light-emitting section 104 is caused to stop emitting light. At this stage, the oxygen measurement processing of the present flow is ended.

[0083] Next, the effects of the present embodiment will be described.

[0084] ​​​The monitoring system 16 is connected with the oxygen measuring device 10A capable of detecting the oxygen partial pressure in the urine in the urethral catheter 18 and the flow of the urine in the urinary tract 74. The monitoring system 16 has an oxygen partial pressure calculating section 120 that calculates the oxygen partial pressure in the urine based on the output signal from the oxygen measuring device 10A (oxygen sensor 20), a monitor 114 that can display the oxygen partial pressure calculated by the oxygen partial pressure calculating section 120, and a display control section 130 that changes the display form of the oxygen partial pressure displayed on the monitor 114 in accordance with the flow rate V of the urine obtained based on the output signal from the oxygen measuring device 10A (flow rate sensor 76).

[0085] Thus, by observing the display form of the oxygen partial pressure displayed on the monitor 114, it is possible to easily know whether the measured oxygen partial pressure is the oxygen partial pressure in the urine flowing stably that properly reflects the state of the kidney.

[0086] The monitoring system 16 has a flow rate determining section 124 that determines whether the obtained flow rate V of the urine is a prescribed value or more (reference flow rate V0 or more). The display control section 130 causes the oxygen partial pressure to be displayed on the monitor 114 in the first display form in the case where the flow rate determining section 124 determines that the flow rate V of the urine is the prescribed value or more, and causes the oxygen partial pressure to be displayed on the monitor 114 in the second display form different from the first display form in the case where the flow rate determining section 124 determines that the flow rate V of the urine is less than the prescribed value. Thus, in the case where the oxygen partial pressure is displayed on the monitor 114 in the first display form, it is possible to easily know that the measured oxygen partial pressure is the oxygen partial pressure in the urine flowing at a flow rate of the reference flow rate V0 or more. Also, in the case where the oxygen partial pressure is displayed on the monitor 114 in the second display form, it is possible to easily know that the measured oxygen partial pressure is the oxygen partial pressure in the urine flowing at a flow rate less than the reference flow rate V0. Thus, it is possible to easily know whether the oxygen partial pressure obtained in a state where the state of the kidney is properly reflected.

[0087] The display control section 130 causes a graph showing the time change of the oxygen partial pressure to be displayed on the monitor 114. Thus, it is possible to more easily know whether the measured oxygen partial pressure is the oxygen partial pressure in the urine flowing at a flow rate of the prescribed value or more. Thus, it is possible to easily know whether the state of the kidney is good compared with before, and thus it is possible to perform an intervention such as treatment or adjustment thereof at an appropriate timing as needed.

[0088] The oxygen partial pressure calculating section 120 calculates the oxygen partial pressure in the urine corrected in accordance with the temperature in the urine obtained based on the output signal from the oxygen measuring device 10A (temperature sensor 44). Thus, it is possible to display the oxygen partial pressure in the urine with higher accuracy after the temperature correction on the monitor 114.

[0089] The monitoring system 16 includes: a urine volume calculation unit 122, which calculates the amount of urine flowing in the urinary tract based on the output signal from the oxygen measurement device 10A (flow sensor 76); and a urine volume determination unit 128, which determines whether the urine volume calculated by the urine volume calculation unit 122 meets the prescribed urine volume conditions. The display control unit 130 displays this information on the monitor 114 when the urine volume determination unit 128 determines that the urine volume meets the urine volume conditions. Therefore, it is easy to know whether the urine volume meets the prescribed urine volume conditions (e.g., whether the urine volume is too low). Thus, compared to the past, it is easier to know whether the kidney condition is good, thereby enabling interventions such as treatment or adjustments at the appropriate time as needed.

[0090] In the monitoring system 16, the display control unit 130 may be configured to display the partial pressure of oxygen on the monitor 114 when the flow rate determination unit 124 determines that the flow rate V of the urine is above a predetermined value, and not display the partial pressure of oxygen on the monitor 114 when the flow rate determination unit 124 determines that the flow rate V of the urine is below the predetermined value. Therefore, when the partial pressure of oxygen is displayed on the monitor 114, it is easy to know that the measured partial pressure of oxygen is the partial pressure of oxygen in urine flowing at a flow rate above the predetermined value. Thus, it is easy to know whether the partial pressure of oxygen was obtained under conditions that appropriately reflect the renal state.

[0091] Alternatively, the monitoring system 16 can be connected to a device 10A that can detect the partial pressure of oxygen in urine flowing within the bladder 140 and outside the urethral catheter 18, as well as the oxygen content of the flowing urine.

[0092] Next, the modified oxygen measuring device 10B will be described. Furthermore, in the modified oxygen measuring device 10B, the same structural elements as those in the oxygen measuring device 10A described above are labeled with the same reference numerals, and detailed descriptions thereof are omitted.

[0093] like Figure 12 As shown, the urethral catheter 18a of the modified oxygen measuring device 10B includes a hub 26a. The hub 26a has a hollow hub body 600 located at the base end of the shaft 22, and a hollow connecting portion 602 located at the base end of the hub body 600. The hub body 600 is integrally formed from resin material. Figure 12 In the hub body 600, there is a first urination port 604 communicating with the urination lumen 42, a balloon dilation port 72 communicating with the dilation lumen 32, and an outlet port 606 for leading the base end of the temperature transmission section 48 to the outside. The balloon dilation port 72 is configured to be connected to a pressure application device (not shown) for pressurizing dilation fluid into the balloon 24 via the dilation lumen 32.

[0094] The connecting portion 602 is integrally formed in a tubular shape by a resin material having transparency. The connecting portion 602 has a first connecting portion 608 which is embedded in the base end opening portion of the hub portion main body 600, a connecting portion main body 610 which is provided at the base end of the first connecting portion 608, and a second connecting portion 612 which is provided at the base end portion of the connecting portion main body 610 and is embedded in the front end opening portion of the urinary catheter 80 of the urine storage bag 14.

[0095] On the outer surface of the first connecting portion 608, a plurality of annular convex portions 614 are provided in the axial direction, whereby the outer surface of the first connecting portion 608 is in liquid-tight contact with the inner surface of the base end opening portion of the hub portion main body 600. A second urine discharge port 616 which communicates with the first urine discharge port 604 is formed in the first connecting portion 608 and the connecting portion main body 610. Hereinafter, there are cases in which the first urine discharge port 604 and the second urine discharge port 616 are collectively referred to as a urine discharge port 618. The urine discharge port 618 constitutes the urinary tract 74a of the urethral catheter 18a. The cross-sectional shapes of the urinary catheter tube 42 and the urine discharge port 618 are formed to be the same (for example, rectangular shapes) with each other. That is, the flow path cross-sectional areas of the urinary catheter tube 42 and the urine discharge port 618 are formed to be the same with each other. Thus, since it is possible to suppress the occurrence of turbulence in the urine flowing from the urinary catheter tube 42 to the urine discharge port 618, it is possible to smoothly flow the urine.

[0096] The second connecting portion 612 has an annular protruding portion 620 which protrudes outward from the connecting portion 602, and an extension portion 622 which extends in the base end direction from the annular protruding portion 620. That is, the flow path cross-sectional area of the inner cavity 624 of the second connecting portion 612 is larger than the flow path cross-sectional area of the second urine discharge port 616. On the outer surface of the extension portion 622, a plurality of annular convex portions 626 are provided in the axial direction, whereby the outer surface of the extension portion 622 is in liquid-tight contact with the inner surface of the front end opening portion of the urinary catheter 80. In the inner cavity 624 of the second connecting portion 612, the base end portion of the connecting portion main body 610 protrudes. The flow path cross-sectional area of the base end side opening portion of a protruding portion 628 (flow-in suppressing portion) of the connecting portion main body 610 which protrudes into the inner cavity 624 of the second connecting portion 612 is smaller than the flow path cross-sectional area of the inner cavity 624 of the second connecting portion 612. That is, since the wall surface which constitutes the base end opening portion of the protruding portion 628 contacts the urine by the surface tension, it is possible to suppress the inflow of air from the inner cavity 624 of the second connecting portion 612 into the second urine discharge port 616.

[0097] On the joint body 610, a port portion 632 for introducing a prescribed fluid into the second urine discharge port 616, a support wall portion 634 on the proximal end side of the port portion 632, an oxygen sensor body 636 constituting an oxygen sensor 660 for detecting oxygen in urine in the second urine discharge port 616, a temperature sensor body 638 constituting a temperature sensor 662 for detecting the temperature of urine in the second urine discharge port 616, and a flow rate sensor body 640 constituting a flow rate sensor 664 for detecting the flow rate of urine in the second urine discharge port 616 are provided.

[0098] The port portion 632 is provided on the distal end side compared with the oxygen sensor body 636, and has a valve core support portion 646 having a hole 644 in which a valve core 642 is disposed. The valve core 642 is constituted by an elastic member 654 such as rubber, and is configured to be able to be liquid-tightly punctured by a hollow needle of an unillustrated syringe, for example. The port portion 632 can also function as a urine collection port portion for collecting urine in the second urine discharge port 616.

[0099] On the surface of the support wall portion 634 directed toward the proximal end direction and the surface of the annular protrusion portion 620 directed toward the distal end direction, fixing holes 650a, 650b for fixing a cable connector 90 of a monitoring system 16 are respectively formed. The oxygen sensor body 636, the temperature sensor body 638, and the flow rate sensor body 640 are disposed in a row between the support wall portion 634 and the protrusion portion 628 from the distal end side in this order, with mutual separation.

[0100] The oxygen sensor body 636 is disposed on the proximal end side compared with the port portion 632 and on the distal end side compared with the temperature sensor body 638 and the flow rate sensor body 640, and has a base portion 656 having a substrate 652 and an elastic portion 654, and a phosphor 658 provided on the base portion 656. The phosphor 658 is applied on the surface of the substrate 652 in a manner to contact urine in the second urine discharge port 616. The elastic portion 654 is provided on the back surface of the substrate 652 on the side opposite the phosphor 658. The substrate 652 and the elastic portion 654 are each constituted by a material having transparency. The substrate 652 and the phosphor 658 are constituted similarly to the above-described substrate 54 and phosphor 56. The elastic portion 654 is constituted by a resin material having softness such as rubber. The phosphor 658 has a larger area than the distal end surface of an oxygen cable 96 described later.

[0101] The temperature sensor main body 638 is disposed on the proximal end side compared with the oxygen sensor main body 636 and on the distal end side compared with the flow rate sensor main body 640. In other words, the temperature sensor main body 638 is located in the vicinity of the oxygen sensor main body 636. The temperature sensor main body 638 is configured as a metal plate. The metal plate is preferably made of a material having a high thermal conductivity such as silver, copper, gold, stainless steel, aluminum, or the like. This is because, in this case, the temperature of the temperature sensor main body 638 can be made substantially the same as the temperature of the urine in the second urine discharge port 616. However, the temperature sensor main body 638 can also be formed as a thin plate from a material other than metal such as a resin material, as long as the temperature of the temperature sensor main body 638 can be made approximately the same as the temperature of the urine in the second urine discharge port 616. The flow rate sensor main body 640 is disposed on the proximal end side compared with the temperature sensor main body 638, and is configured as a flow rate sensor 664 such as a Karman vortex type or a thermal type, for example.

[0102] The cable connector 90 has a housing 91 in which an oxygen cable 96 as an optical fiber capable of being optically connected to the oxygen sensor main body 636, a temperature detection portion 97 capable of being in contact with or in the vicinity of the temperature sensor main body 638, an oxygen cable 98 capable of being electrically connected to the temperature detection portion 97, and a flow rate cable 100 capable of being electrically connected to the flow rate sensor main body 640 are disposed.

[0103] The cable connector 90 is attached to or detached from the hub portion 26a from a direction intersecting (orthogonal to) the axis of the hub portion 26a. The housing 91 is provided with a pin 93a capable of being inserted into the fixing hole 650a and a pin 93b capable of being inserted into the fixing hole 650b. Each of the pins 93a and 93b is configured to be displaced to a locked position in which the pin 93a or 93b protrudes to the outside of the housing 91 and can be inserted into each of the fixing holes 650a and 650b, and a retracted position in which the pin 93a or 93b is retracted to the inside of the housing 91 and is detached from each of the fixing holes 650a and 650b, by operating an unillustrated operation portion provided to the housing 91. The housing 91 is provided with a connection terminal 95 to which a terminal 49 provided to the proximal end of the temperature transmission portion 48 can be electrically connected. An unillustrated cable is electrically connected to the connection terminal 95.

[0104] Further, the control portion 116 is provided with an unillustrated temperature input portion that inputs the output signal of the temperature sensor 662 and an unillustrated flow rate input portion that inputs the output signal of the flow rate sensor 664.

[0105] Even the oxygen measurement apparatus 10B of such a modification example has the same effects as in the case of the above-described oxygen measurement apparatus 10A.

[0106] The oxygen measurement apparatuses 10A and 10B can be provided with a pressure sensor that measures the pressure in the vicinity of the distal end of the urethral catheter 18 or 18a. The pressure sensor outputs an electric signal or an optical signal to the monitoring system 16.

[0107] The monitor main unit 94 can also be configured to acquire time, atmospheric pressure around the monitor main unit 94, humidity around the monitor main unit 94, and temperature around the monitor main unit 94. Further, the time includes the current time and elapsed time from a certain time. The monitor main unit 94 can be configured to read and reflect the initial (at the time of manufacture) calibration values inherent to each sensor. The input method of the calibration values can be to scan a one-dimensional or two-dimensional bar code, or to input directly from the monitor 114. Alternatively, the calibration values can be held in the signal output portion of the urethral catheter 18, 18a, and read automatically by connecting the monitoring system 16 to the urethral catheter 18, 18a.

[0108] In the oxygen measurement system 12, action confirmation can also be performed before use. In this case, it is confirmed that the output values from each sensor of the oxygen measurement apparatus 10A, 10B are within the normal action range. Specifically, the output values from each sensor of the oxygen measurement apparatus 10A, 10B are compared with reference values calculated from the temperature, humidity, and atmospheric pressure around the monitor main unit 94. Further, the control portion 116 of the monitor main unit 94 determines whether the output values from each sensor of the oxygen measurement apparatus 10A, 10B are within the normal range, and reports the determination result. Further, the confirmation that the output values from each sensor of the oxygen measurement apparatus 10A, 10B are within the normal range can also be performed using a reference solution or a reference gas to acquire the output values from each sensor, and comparing the output values with the reference values.

[0109] The monitor main unit 94 can also report various physical quantities (oxygen partial pressure, temperature inside the bladder 140, urine volume, etc.) based on the output values from each sensor of the oxygen measurement apparatus 10A, 10B. Specifically, the monitor main unit 94 can report the physical quantities by numerical values, histograms, dials, level meters, colors, etc. Further, the monitor main unit 94 can display the progress of the physical quantities on the monitor 114 by up and down arrows, various graphs (line graphs, etc.), color changes, etc.

[0110] There is a time lag before the change in the bladder 140 appears as a change in the flow rate of urine in the oxygen measurement apparatus 10A, 10B. Therefore, the monitor main unit 94 can also display the change in the bladder 140 as a delay time before the output values from each sensor of the oxygen measurement apparatus 10A, 10B on the monitor 114.

[0111] The monitor main unit 94 can be set with a prescribed condition by the user. The monitor main unit 94 can also determine and notify whether a state satisfying the set condition has passed a set time. That is, the monitor main unit 94 can also notify, for example, in a case where discharge urine cannot be obtained in a set amount of urine, in a case where a state satisfying a set condition (a low output state of the sensor, a state where the temperature in the bladder 140 is less than a set temperature, etc.) continues for a set time or more, and the like.

[0112] The monitor main unit 94 can also determine and notify that a set change has occurred. That is, the monitor main unit 94 can also notify, for example, in a case where a rate of change in the amount of urine exceeds a set rate of change, in a case where a change range in the measured temperature of urine exceeds a set change range, and the like.

[0113] The monitor main unit 94 can also be configured to have a function of holding a program inside, and be able to update the program by receiving update information from the outside. In this case, the monitor main unit 94 can receive the update information by making a wireless connection or a wired connection (USB connection) with respect to a source of the update information. In addition, the monitor main unit 94 can also receive the update information by replacing a memory card.

[0114] The monitor main unit 94 can also be configured to be able to simply operate necessary functions. That is, the monitor main unit 94 can also be configured to have at least one physical function key, and be able to freely assign functions to each function key. The monitor main unit 94 can also be configured to be able to perform a time trace operation of past data by operating a degree dial and / or performing a slide operation on the monitor 114 (screen), for example.

[0115] The monitor main unit 94 can also be configured to be able to print data of a selected range from an external printer or the like.

[0116] The monitor main unit 94 can also be configured to divide a display area of the monitor 114 and display arbitrary data on each display area. In this case, for example, it is possible to easily compare current data and past data. The monitor main unit 94 can also be configured to be able to output a display of the monitor 114 to an external display device and display.

[0117] The monitor main unit 94 can also be configured to estimate a range of the amount of urine discharged from the amount of infusion, compare the estimated range and the actual amount of urine discharged, determine whether it is within the estimated range, and notify the determination result. Furthermore, the amount of infusion can be automatically acquired from an infusion pump, or the amount of infusion can be directly input.

Claims

1. A monitoring system capable of connecting with an oxygen measurement apparatus provided with a sensor for calculating oxygen partial pressure in urine and flow rate of urine, characterized by comprising: an oxygen partial pressure calculating section that calculates oxygen partial pressure in urine based on an output signal from the oxygen measurement apparatus; a flow rate calculating section that calculates flow rate of urine based on an output signal from the oxygen measurement apparatus; a flow rate determining section that determines whether or not the flow rate of urine acquired based on an output signal from the oxygen measurement apparatus is a prescribed value or more; and a display control section that causes the calculated oxygen partial pressure to be displayed on a monitor, the display control section causing a graph showing temporal change of the oxygen partial pressure to be displayed on the monitor, the graph causing the oxygen partial pressure to be displayed in a first display form in a case where the flow rate of urine is determined by the flow rate determining section to be a prescribed value or more, the graph causing the oxygen partial pressure to be displayed in a second display form different from the first display form in a case where the flow rate of urine is determined by the flow rate determining section to be less than a prescribed value.

2. The monitoring system according to claim 1, characterized in that the display control section causes the oxygen partial pressure to be displayed on the monitor as a numerical value together with the graph showing the temporal change.

3. The monitoring system according to claim 1, characterized in that the temporal change of the oxygen partial pressure is displayed in a histogram in the monitor, the first display form is indicated in a colored state and the second display form is indicated in a non-colored state in the histogram, or the first display form is indicated in a non-colored state and the second display form is indicated in a colored state.

4. The monitoring system according to claim 1, characterized in that the temporal change of the oxygen partial pressure is displayed in a line graph in the monitor, the first display form is indicated in a thick line and the second display form is indicated in a thin line in the line graph, or the first display form is indicated in a thin line and the second display form is indicated in a thick line.

5. The monitoring system according to claim 1, characterized in that the temporal change of the oxygen partial pressure is displayed in a line graph in the monitor, the first display form is indicated in a state where the lower side of a line segment showing a value of the oxygen partial pressure is colored and the second display form is indicated in a state where the lower side of the line segment showing the value of the oxygen partial pressure is not colored in the line graph, or the first display form is indicated in a state where the lower side of the line segment showing the value of the oxygen partial pressure is not colored and the second display form is indicated in a state where the lower side of the line segment showing the value of the oxygen partial pressure is colored.

6. The monitoring system according to any one of claims 3 to 5, characterized in that the oxygen partial pressure calculating section calculates oxygen partial pressure in urine corrected based on temperature in urine acquired based on an output signal from the oxygen measurement apparatus, the monitoring system further comprising: a urine amount calculating section that calculates an amount of urine based on an output signal from the oxygen measurement apparatus; and a urine amount determining section that determines whether or not the amount of urine calculated by the urine amount calculating section meets a prescribed urine amount condition. ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ 7. The monitoring system according to any one of claims 3 to 5, wherein ​ ​ ​ The display control section displays to the monitor that the urine volume meets the urine volume condition when the urine volume meets the urine volume condition is determined by the urine volume determination section.

8. An oxygen measurement system characterized by, Possessing: A urethral catheter having a urinary tract through which urine flows; An oxygen sensor capable of outputting a signal for calculating the oxygen partial pressure in the urine flowing in the urethral catheter; A flow rate sensor capable of outputting a signal for calculating the flow rate of the urine flowing in the urethral catheter; An oxygen partial pressure calculation section that calculates the oxygen partial pressure in the urine based on the output signal from the oxygen sensor; A flow rate calculation section that calculates the flow rate of the urine based on the output signal from the flow rate sensor; A flow rate determination section that determines whether the flow rate of the urine calculated by the flow rate calculation section is a prescribed value or more; and A display control section that causes the oxygen partial pressure calculated by the oxygen partial pressure calculation section to be displayed to a monitor, The display control section causes a graph showing the time change in the oxygen partial pressure to be displayed to the monitor, The graph causes the oxygen partial pressure to be displayed in a first display form when the flow rate of the urine is determined by the flow rate determination section to be a prescribed value or more, The graph causes the oxygen partial pressure to be displayed in a second display form different from the first display form when the flow rate of the urine is determined by the flow rate determination section to be less than a prescribed value.

9. The oxygen measurement system according to claim 8, wherein The display control section causes the oxygen partial pressure to be displayed to the monitor as a numerical value together with the graph showing the time change.

10. The oxygen measurement system according to claim 8, wherein In the monitor, the time change in the oxygen partial pressure is displayed as a histogram, In the histogram, the first display form is indicated in a colored state and the second display form is indicated in a non-colored state; or The first display form is indicated in a non-colored state and the second display form is indicated in a colored state.

11. The oxygen measurement system according to claim 8, wherein In the monitor, the time change in the oxygen partial pressure is displayed as an open-and-closed line graph, In the open-and-closed line graph, the first display form is indicated by a thick line and the second display form is indicated by a thin line; or The first display form is indicated by a thin line and the second display form is indicated by a thick line.

12. The oxygen measurement system according to claim 8, wherein In the monitor, the time change in the oxygen partial pressure is displayed as an open-and-closed line graph, In the open-and-closed line graph, the first display form is indicated in a state in which the lower side of a line segment showing the value of the oxygen partial pressure is colored and the second display form is indicated in a state in which the lower side of the line segment showing the value of the oxygen partial pressure is not colored; or The first display form is indicated in a state in which the lower side of the line segment showing the value of the oxygen partial pressure is not colored and the second display form is indicated in a state in which the lower side of the line segment showing the value of the oxygen partial pressure is colored.

13. The oxygen measurement system according to any one of claims 10 to 12, further comprising a temperature sensor for detecting the temperature in the urine, ​ ​ ​ ​ The oxygen partial pressure calculation section calculates the oxygen partial pressure in the urine corrected based on the temperature in the urine obtained based on the output signal from the temperature sensor.

14. The oxygen measurement system of any one of claims 10 to 12, wherein, Possesses: a urine amount calculation section that calculates the amount of urine based on the output signal from the flow rate sensor; and a urine amount determination section that determines whether the amount of urine calculated by the urine amount calculation section meets a prescribed urine amount condition, the display control section causes the monitor to display the gist that the amount of urine meets the urine amount condition in a case where the amount of urine is determined by the urine amount determination section to meet the urine amount condition.

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