Multi-degree-of-freedom stepless adjustment device for surface plasmon resonance detector

Abstract

The invention discloses a multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector. A light source adjustment unit and a CCD adjustment unit are symmetrically arranged and connected via a connecting piece. The light source adjustment unit and the CCD adjustment unit have the same structure and both include a base. The base is provided with an up-and-down movable platform, the up-and-down movable platform is provided with a forward-and-backward movable platform, the forward-and-backward movable platform is provided with a forward-and-backward rotating platform, the forward-and-backward rotating platform is provided with an up-and-down rotating platform, the upper and lower rotating platforms are connected to a left-and-right movable platform, and an optical device is rotatably arranged on the left-and-right movable platform. The device has a total of six degrees of freedom, including up-and-down movement, forward-and-back movement, up-and-down rotation, forward-and-backward rotation, left-and-right movement, and rotation around an optical axis, and a wider adjustable range. Each degree of freedom can be adjusted individually, and adjusting one degree of freedom will not affect other degrees of freedom. The degree of freedom is adjusted steplessly, can be precisely fine-tuned, and has a self-locking function.

Description

Technical Field

[0001] The present invention relates to the field of surface plasmon resonance detection, in particular to a multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector. Background Art

[0002] Surface Plasmon Resonance (SPR) is a new biosensor analysis technology based on the SPR principle. This technology is a complex optical phenomenon, such as Figure 1 As shown in the figure, when the parallel polarization component of the incident light undergoes total internal reflection at the interface between the glass and the gold film, an evanescent wave is generated. It enters the gold film and excites the free electrons therein to generate a surface plasma wave (SPW). When the incident light propagates at a certain angle from the optically denser medium (glass prism) to the optically rarer medium (air), if the angle of incidence is greater than the critical angle, the refracted light disappears, resulting in total internal reflection. During total reflection, the light wave transmits one wavelength through the optically rarer medium, then flows along the interface for approximately half a wavelength before returning to the optically denser medium. The wave flowing along the interface is called an evanescent wave. If a layer of gold is applied to the surface of the glass prism, the motion of the free electrons on the gold film surface will form a surface plasma. The plasma will oscillate due to electromagnetic interference, forming a plasma wave. When incident light strikes the interface between the glass prism and the gold film at an angle greater than the critical angle, the evanescent wave formed by the total internal reflection of the incident light resonates with the plasma wave on the gold film surface under certain conditions (appropriate wavelength or incident angle). During resonance, most of the energy of the incident light is absorbed by the plasma wave, and the energy of the reflected light decreases sharply. When the wavelength of the incident light is fixed and the incident angle is greater than the critical angle, the curve of the reflected light intensity varying with the incident angle forms a deep valley. The horizontal coordinate position corresponding to the valley bottom is the angle of the incident angle when the resonance occurs, which is called the SPR angle. The SPR angle varies with the refractive index of the gold film surface, and the change in refractive index is mainly proportional to the mass of the molecules bound to the gold surface. Therefore, the dynamic changes in the SPR angle during biological reactions can be used to obtain specific signals of interactions between biomolecules.

[0003] Surface plasmon resonance (SPR) detection technology relies on multiple characteristic parameters, the most important of which are incident light and reflected light. When incident light strikes a gold film, the refractive index at the interface between the film and the medium being measured changes. A computer collects the reflected light signal in real time, allowing the SPR system to obtain parameters such as the concentration and refractive index of the substance being measured, thus achieving the purpose of biochemical detection. Therefore, the position and range of the incident light, and the angle and range of the reflected light, are both crucial for SPR detection.

[0004] Patent CN102095684 A discloses a multi-degree-of-freedom adjustment mechanism for an optical surface plasmon resonance biosensor. However, the adjustment mechanism is overly simple, leading to the following issues during adjustment:

[0005] 1. When adjusting multiple degrees of freedom simultaneously, since multiple degrees of freedom act on the adjustment mechanism at the same time, it is inevitable that unexpected adjustments will be made to other degrees of freedom when adjusting one of the degrees of freedom.

[0006] 2. The size adjustment is not precise. When adjusting, it is only adjusted by feel and cannot be adjusted accurately.

[0007] 3. Lack of adjustment freedom. The adjustment freedom is not comprehensive and lacks freedom in actual use.

[0008] The purpose of the present invention is to solve the problem of adjusting the incident angle and incident range of incident light and adjusting the receiving angle and receiving range of reflected light. Summary of the Invention

[0009] The object of the present invention is to provide a multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector to solve the problem of poor adjustment effects of the incident angle and incident range, and the receiving angle and receiving range in the above-mentioned prior art.

[0010] To achieve the above object, the present invention provides the following solutions:

[0011] The present invention provides a multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector, comprising a light source adjustment unit and a CCD adjustment unit, wherein the light source adjustment unit and the CCD adjustment unit are symmetrically arranged and connected by a connector;

[0012] The light source adjustment unit and the CCD adjustment unit have the same structure and both include a base, an up and down moving platform is provided on the base, a front and back moving platform is provided on the up and down moving platform, a front and back rotating platform is provided on the front and back rotating platform, an up and down rotating platform is provided on the front and back rotating platform, a left and right moving platform is connected to the up and down rotating platform, and the optical device is rotatably arranged on the left and right moving platform.

[0013] Preferably, the base includes a bottom plate, a guide shaft is vertically provided on the bottom plate, left and right movable guide rails are provided on both sides of the bottom plate, slopes are provided on the left and right movable guide rails, a first adjustment screw is provided between the left and right movable guide rails, and positioning components are provided on the sides of the left and right movable guide rails.

[0014] Preferably, the up and down movable platform includes an up and down movable platform body, the up and down movable platform body can be slidably limited on the guide shaft, the side of the up and down movable platform body is provided with a movable slider and a forward and backward movable transmission member, the movable slider can be slidably limited in the slope, and the first adjustment screw acts on the movable slider.

[0015] Preferably, the forward and backward moving platform includes a forward and backward moving platform body, the forward and backward moving platform body is provided with a forward and backward moving guide rail, and is slidably arranged on the upper and lower moving platform body through the guide shaft, and the side of the forward and backward moving platform body is provided with a second adjustment screw, and the second adjustment screw acts on the forward and backward moving transmission member.

[0016] Preferably, the front-rear rotating platform includes a front-rear rotating platform body, the front-rear rotating platform body is rotatably arranged on the front-rear movable platform body through a first rotating shaft, and the front-rear rotating platform body is provided with a positioning fixing screw.

[0017] Preferably, a rotation scale is provided around the first rotation axis, and a pointer is provided on the upper surface of the first rotation axis.

[0018] Preferably, the up-and-down rotating platform includes an up-and-down rotating platform body, the up-and-down rotating platform body is fixed on the front-and-rear rotating platform body, and a second rotating shaft is provided on the top of the up-and-down rotating platform body.

[0019] Preferably, the left-right movable platform includes a left-right movable platform body, the left-right movable platform body is rotatably connected to the second rotating shaft, the optical device is rotatably arranged on the left-right movable platform body, and a third adjustment screw is provided on the side of the left-right movable platform body, and the third adjustment screw acts on the optical device.

[0020] Compared with the prior art, the present invention has achieved the following beneficial technical effects:

[0021] 1. The multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector provided by the present invention includes six degrees of freedom: up and down movement, front and back movement, up and down rotation, front and back rotation, left and right movement, and rotation around the optical axis, which has a wider adjustable range;

[0022] 2. Each degree of freedom of the multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector provided by the present invention can be adjusted independently, and adjusting one degree of freedom will not affect other degrees of freedom;

[0023] 3. The multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector provided by the present invention can adjust the degrees of freedom steplessly, can perform precise fine-tuning, and has a self-locking function. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0025] Figure 1 Schematic diagram of the principle of SPR phenomenon;

[0026] Figure 2 A schematic structural diagram of a multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector provided by the present invention;

[0027] Figure 3 A schematic diagram of the structure of a light source adjustment unit of a multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector provided by the present invention;

[0028] Figure 4 A schematic structural diagram of the base portion of the multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector provided by the present invention;

[0029] Figure 5 This is a schematic diagram of the structure of the upper and lower moving platform of the multi-degree-of-freedom stepless adjustment device for the surface plasmon resonance detector provided by the present invention;

[0030] Figure 6 A schematic diagram of the up and down movement state of the multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector provided by the present invention;

[0031] Figure 7 This is a schematic diagram of the structure of the forward and backward moving platform of the multi-degree-of-freedom stepless adjustment device for the surface plasmon resonance detector provided by the present invention;

[0032] Figure 8 A schematic diagram of the forward and backward movement state of the multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector provided by the present invention;

[0033] Figure 9 This is a schematic diagram of the structure of the front and rear rotating platform of the multi-degree-of-freedom stepless adjustment device for the surface plasmon resonance detector provided by the present invention;

[0034] Figure 10 A schematic diagram of the forward and backward rotation state of the multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector provided by the present invention;

[0035] Figure 11This is a schematic diagram of the structure of the upper and lower rotating platforms of the multi-degree-of-freedom stepless adjustment device for the surface plasmon resonance detector provided by the present invention;

[0036] Figure 12 A schematic diagram of the left-right movement state of the multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector provided by the present invention;

[0037] Figure 13 Schematic diagram of the degrees of freedom of the multi-degree-of-freedom stepless adjustment device for the surface plasmon resonance detector provided by the present invention

[0038] In the figure: 1: light source adjustment unit, 11: base, 111: bottom plate, 112: guide shaft, 113: left and right moving guide rail, 114: first adjustment screw, 115: positioning component, 12: up and down moving platform, 121: up and down moving platform body, 122: moving slider, 123: front and back moving transmission member, 13: front and back moving platform, 131: front and back moving platform body, 132: second adjustment screw, 133: front and back moving guide rail, 14: front and back rotating platform, 141: front and back rotating platform body, 142: first rotating axis, 15: up and down rotating platform, 151: up and down rotating platform body, 152: second rotating axis, 16: left and right moving platform, 161: third adjustment screw, 162: left and right moving platform body, 2: CCD adjustment unit, 3: connecting part. DETAILED DESCRIPTION

[0039] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0040] The purpose of the present invention is to provide a multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector to solve the problem of poor adjustment effects of the incident angle and incident range, and the receiving angle and receiving range in the prior art.

[0041] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0042] Example 1:

[0043] This embodiment provides a multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector, such as Figure 2As shown, it includes a light source adjustment unit 1, a CCD adjustment unit 2 and a connector 3 for connecting the two units. The light source adjustment unit 1 and the CCD adjustment unit 2 have the same structure and are symmetrically placed on the left and right.

[0044] Specifically, taking the light source adjustment unit 1 as an example, Figure 3 and 13 As shown, the light source adjustment unit 1 includes a base 11, an up and down moving platform 12, a front and back moving platform 13, a front and back rotating platform 14, an up and down rotating platform 15 and a left and right moving platform 16 connected in sequence. A light source is installed in the left and right moving platform 16, which can realize adjustment with a total of 6 degrees of freedom including up and down movement, front and back movement, up and down rotation, front and back rotation, left and right movement, and rotation around the optical axis.

[0045] Furthermore, if Figure 4 As shown, the base 11 includes a bottom plate 111 and a guide shaft 112, and the guide shaft 112 is vertically fixed on the bottom plate 111; left and right movable guide rails 113 are provided on both sides of the bottom plate 111, which are placed parallel to the bottom plate 111 and can move left and right on the bottom plate, and a slowly rising slope is provided on the left and right movable guide rails 113; an adjustment screw 114 is provided between the left and right movable guide rails 113, which is fixed on the bottom plate 111 and connected to the left and right movable guide rails 113; and a positioning component 115 is also included for positioning.

[0046] Furthermore, if Figure 5 As shown, the vertical moving platform 12 includes a vertical moving platform body 121, on which a forward and backward moving transmission member 123 and a moving slider 122 are provided, both of which are respectively arranged on both sides of the vertical moving platform body.

[0047] When you need to move up and down, such as Figure 6 As shown, since the up and down movable platform 12 is placed on the guide shaft 112 of the base 11, the up and down movable platform 12 can slide up and down along the guide shaft 112, and the movable slider 122 is close to the slope on the left and right movable guide rails 113, and the movable slider 122 can slide along the slope on the left and right movable guide rails 113; by rotating the first adjusting screw 114, the movable slider 122 is driven to move left and right on the base plate 111, and the movable slider 122 then drives the up and down movable platform body 121 to move up and down along the guide shaft 112, thereby realizing up and down movement adjustment; the up and down adjustment is realized by converting the spiral motion into left and right movement and then into up and down movement. The up and down adjustment amount depends on the motion amount of the spiral motion. The pitch and length of the first adjusting screw 114 can adjust the accuracy and range of the up and down movement, and due to the self-locking nature of the screw, the positioning of the up and down adjustment can be achieved.

[0048] Furthermore, if Figure 7As shown, the front-to-back movable platform 13 includes a front-to-back movable platform body 131 , on which a second adjusting screw 132 and a front-to-back movable guide rail 133 are provided.

[0049] When you need to move forward and backward, such as Figure 8 As shown, since the forward and backward moving guide rails 133 of the forward and backward moving platform 13 are installed on the guide shaft 112 and placed on the upper and lower moving platforms 12, the second adjusting screw 132 is connected to the forward and backward moving transmission member 123 on the upper and lower moving platforms 12. At this time, by rotating the second adjusting screw 132, the forward and backward moving platform body 131 can be adjusted to move forward and backward along the moving guide rails 133; similarly, the adjustment amount depends on the amount of movement of the spiral movement. The accuracy and range of the forward and backward movement can be adjusted by adjusting the pitch and length of the screw, and due to the self-locking nature of the screw, the positioning of the forward and backward adjustment can be achieved.

[0050] Furthermore, if Figure 9 As shown, the front-rear rotating platform 14 includes a front-rear rotating platform body 141 and a first rotating shaft 142 . A rotating scale is arranged around the first rotating shaft 142 , and a pointer is arranged on the first rotating shaft 142 .

[0051] When you need to adjust the front and back rotation, such as Figure 10 As shown, since the first rotating shaft 142 of the front and rear rotating platform 14 is fixed on the front and rear moving platform 13, the angle can be adjusted according to the scale when rotating, and the positioning screws are used to fix it.

[0052] Furthermore, if Figure 11 As shown, the vertical rotating platform 15 includes an vertical rotating platform body 151 and a second rotating shaft 152 , and the vertical rotating platform 15 is fixed on the front and rear rotating platforms 14 .

[0053] Furthermore, if Figure 12 As shown, the left-right movable platform 16 includes a left-right movable platform body 162 and a third adjustment screw 161. The left-right movable platform 16 is mounted on the vertical rotating platform 15. The light source is mounted on the left-right movable platform body 162, and the adjustment screw 161 is mounted on the light source. By rotating the third adjustment screw 161, the light source can be adjusted left-right along the left-right movable platform body 162. Similarly, the amount of adjustment depends on the amount of movement of the screw. The pitch and length of the third adjustment screw 161 can adjust the accuracy and range of the left-right movement. Furthermore, due to the self-locking nature of the screw, the positioning of the left-right adjustment can be achieved. In addition, the left-right movable platform 16 provides another degree of freedom: rotational freedom about the optical axis.

[0054] The present invention provides a multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector, which includes six degrees of freedom: up and down movement, front and back movement, up and down rotation, front and back rotation, left and right movement, and rotation around the optical axis. The adjustable range is wider. Each degree of freedom can be adjusted individually, and adjusting one degree of freedom will not affect other degrees of freedom. The degree of freedom is adjusted steplessly, precise fine-tuning can be performed, and it has a self-locking function, which effectively solves the problem of poor adjustment effect of existing devices.

[0055] The present invention uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only intended to help understand the method and core concept of the present invention. At the same time, those skilled in the art will find that the specific implementation methods and application scopes may vary based on the concept of the present invention. In summary, the contents of this specification should not be understood as limiting the present invention.

Claims

1. A multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector, characterized in that: It includes a light source adjustment unit and a CCD adjustment unit, the light source adjustment unit and the CCD adjustment unit are symmetrically arranged and connected by a connecting piece; The light source adjustment unit and the CCD adjustment unit have the same structure and both include a base, a vertical movable platform is provided on the base, a front-to-back movable platform is provided on the vertical movable platform, a front-to-back rotating platform is provided on the front-to-back rotating platform, a vertical rotating platform is provided on the front-to-back rotating platform, a left-right movable platform is connected to the vertical rotating platform, and an optical device is rotatably provided on the left-to-right movable platform; The base includes a bottom plate, a guide shaft is vertically provided on the bottom plate, left and right movable guide rails are provided on both sides of the bottom plate, the left and right movable guide rails are provided with slopes, a first adjustment screw is provided between the left and right movable guide rails, and positioning components are provided on the sides of the left and right movable guide rails; The vertically movable platform includes a vertically movable platform body, the vertically movable platform body is slidably limited on the guide shaft, a movable slider and a forward and backward movable transmission member are provided on the side of the vertically movable platform body, the movable slider is slidably limited in the slope, and the first adjusting screw acts on the movable slider; The forward and backward movable platform includes a forward and backward movable platform body, the forward and backward movable platform body is provided with a forward and backward movable guide rail, and is slidably arranged on the up and down movable platform body through the guide shaft, and a second adjustment screw is provided on the side of the forward and backward movable platform body, and the second adjustment screw acts on the forward and backward movable transmission member; The front-to-back rotating platform includes a front-to-back rotating platform body, the front-to-back rotating platform body is rotatably arranged on the front-to-back movable platform body via a first rotating shaft, and a positioning fixing screw is provided on the front-to-back rotating platform body; The up-and-down rotating platform comprises an up-and-down rotating platform body, which is fixed on the front-and-rear rotating platform body. A second rotating shaft is provided on the top of the up-and-down rotating platform body.

2. The multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector according to claim 1, characterized in that: A rotation scale is provided around the first rotation axis, and a pointer is provided on the upper surface of the first rotation axis.

3. The multi-degree-of-freedom stepless adjustment device for a surface plasmon resonance detector according to claim 1, characterized in that: The left-right movable platform includes a left-right movable platform body, which is rotatably connected to the second rotating shaft. The optical device is rotatably arranged on the left-right movable platform body. A third adjustment screw is provided on the side of the left-right movable platform body, and the third adjustment screw acts on the optical device.

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