An automatic semen processing system and a control method thereof

Abstract

The application discloses a semen automatic processing system and a control method thereof, and belongs to the field of assisted reproductive technology. The system comprises a semen cup processing module, a printing and labeling module, a visual system and a pipetting mechanism. The semen cup processing module is used for checking the RFID tag information according to the patient information in a medical record system; the printing and labeling module is used for sticking the printed RFID tag information to a first centrifugal tube; the visual system is used for detecting the demarcation line between the first supernatant and the first precipitate in the first centrifugal tube after centrifugation; the pipetting mechanism is used for taking out the first supernatant according to the demarcation line, and obtaining the first centrifugal tube with the first precipitate left; and the opening and closing cover mechanism is used for centrifuging the first centrifugal tube by a centrifuge, obtaining the first supernatant and the first precipitate, and moving the first centrifugal tube with the culture solution and the first precipitate to a centrifugal tube rack. The application can automatically execute various semen washing operations, and solves the problem that the current semen washing operation in an assisted reproductive laboratory is prone to incomplete washing or sperm loss by manual semen washing.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of semen processing, in particular to a semen automatic processing system and a control method thereof. BACKGROUND

[0002] At present, in an assisted reproductive laboratory, semen washing (processing of a semen sample) is usually achieved by manually using a sterile Pasteur pipette to aspirate, discharge or mix and centrifuge the semen sample and a washing solution with a centrifuge. This operation is repeated, tedious, labor-consuming, and different operators may have certain deviations due to individual differences. Manual operation is prone to cause excessive supernatant residue or sperm loss. For example, during the operation, the removal amount of supernatant (waste liquid) is monitored by the human eye, which causes excessive supernatant residue or the aspiration of precipitate (sperm), resulting in incomplete washing or sperm loss. SUMMARY

[0003] In view of the above technical problems, the present application aims to provide a semen automatic processing system and a control method thereof, which solve the problems of traditional semen processing operation, labor consumption, large deviation of manual operation, and excessive supernatant residue or sperm loss.

[0004] The present application adopts the following technical solutions:

[0005] A semen automatic processing system, which is in communication connection with an upper computer, comprises:

[0006] A cup processing module, configured to read RFID tag information on a semen cup and check the RFID tag information according to patient information in a medical record system;

[0007] A printing and labeling module, configured to print the RFID tag information after the RFID tag information is checked and to paste the printed RFID tag information on a first centrifugal tube; and configured to write RFID tag information read from a semen cup into the printed RFID tag or to bind card number information of the printed RFID tag with the RFID tag information read from the semen cup;

[0008] A vision system, configured to detect a boundary line between first supernatant and first precipitate in the first centrifugal tube after centrifugation;

[0009] A pipetting mechanism, configured to transfer a semen sample in the semen cup to the first centrifugal tube containing gradient liquid; and configured to take out the first supernatant according to the boundary line to obtain the first centrifugal tube with the first precipitate left;

[0010] The opening and closing cover mechanism is used to take out the first centrifugal tube from the consumable area, and send the first centrifugal tube containing the semen sample and the gradient liquid to the centrifuge, so that the centrifuge centrifuges the first centrifugal tube to obtain the first supernatant and the first precipitate; so that the printing and labeling module reads the RFID tag information on the first centrifugal tube taken out from the centrifuge, and takes the read RFID tag information as the information source of printing and writing / binding RFID tag information when the tube is replaced; and is also used to move the first centrifugal tube containing the culture solution and the first precipitate to the centrifugal tube rack.

[0011] Optionally, the semen cup processing module is further used to read the visual information on the semen cup and store the visual information.

[0012] Optionally, it further comprises an air cleaning module, which is used to provide clean air for the operation space of the semen automatic processing system, so that the cleanliness of the operation space of the semen automatic processing system reaches a preset level.

[0013] Optionally, it further comprises an illumination disinfection system, which is used to sterilize and disinfect the operation space of the semen automatic processing system.

[0014] A control method of a semen automatic processing system, comprising the following steps:

[0015] The semen sample is obtained by the semen cup processing module, and the processing operation instruction for the semen sample sent by the upper computer is received;

[0016] According to the processing operation instruction, the semen processing operation process is executed, which comprises:

[0017] Information checking operation: the RFID tag information on the semen cup is read by the semen cup processing module, and the RFID tag information is checked according to the patient information in the medical record system; after checking, the first centrifugal tube consumable area is taken out by the opening and closing cover mechanism, and the RFID tag information is printed by the printing and labeling module, and the printed RFID tag information is pasted on the first centrifugal tube;

[0018] Semen separation operation: the semen sample in the semen cup is transferred to the first centrifugal tube containing the gradient liquid by the pipetting mechanism, the first centrifugal tube containing the semen sample and the gradient liquid is sent to the centrifuge by the opening and closing cover mechanism, so that the centrifuge centrifuges the first centrifugal tube to obtain the first supernatant and the first precipitate; the first centrifugal tube after centrifugation is taken out by the opening and closing cover mechanism, the demarcation line of the first supernatant and the first precipitate in the first centrifugal tube after centrifugation is detected by the vision system, and the first supernatant is taken out by the pipetting mechanism according to the demarcation line to obtain the first centrifugal tube containing the first precipitate;

[0019] Semen culture operation: the culture solution is sucked into the first centrifuge tube containing the first precipitate by the pipetting mechanism, and the first centrifuge tube containing the culture solution and the first precipitate is moved to the centrifuge tube rack by the opening and closing cover mechanism.

[0020] Optionally, the information checking operation further includes: reading the visual information on the semen cup by the semen cup processing module, and storing the visual information.

[0021] Optionally, the semen processing operation process further includes:

[0022] Liquid preparation operation: the third centrifuge tube is taken out from the consumable area by the opening and closing cover mechanism, the preset solution in the preset solution bottle is transferred into the third centrifuge tube by the pipetting mechanism, and the third centrifuge tube containing the preset solution is moved to the centrifuge tube rack by the opening and closing cover mechanism.

[0023] Optionally, after the step of taking out the supernatant according to the demarcation line to obtain the first centrifuge tube containing the first precipitate, and before the semen culture operation step, the control method further includes: according to the processing operation instruction, performing a centrifugation operation process one or more times; the centrifugation operation process includes: transferring the precipitate in the n-1th centrifuge tube into the nth centrifuge tube by the pipetting mechanism, n being a natural number greater than 2; sending the nth centrifuge tube to the centrifuge by the opening and closing cover mechanism, so that the centrifuge centrifuges the nth centrifuge tube to obtain the nth supernatant and the nth precipitate; taking out the nth centrifuge tube that has completed centrifugation by the opening and closing cover mechanism; detecting the demarcation line between the nth supernatant and the nth precipitate in the nth centrifuge tube that has completed centrifugation by the vision system; and taking out the nth supernatant according to the demarcation line by the pipetting mechanism to obtain the nth centrifuge tube containing the nth precipitate; and the semen culture operation step includes: sucking the culture solution into the nth centrifuge tube containing the nth precipitate by the pipetting mechanism.

[0024] An electronic device includes at least one processor, and a memory connected to the at least one processor in communication, wherein the memory stores instructions executable by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to perform the control method of the automatic semen processing system.

[0025] A computer storage medium having a computer program stored thereon, the computer program being executed by a processor to implement the control method of the automatic semen processing system.

[0026] Compared with the prior art, the beneficial effects of the present application are:

[0027] The application can realize automatic execution of various sperm washing operations, and can ensure maximum extraction of high-purity precipitate, solve the problem of easy washing of sperm by artificial washing or sperm loss in current assisted reproductive laboratory sperm washing operation, and liberate the operator from tedious repetitive work.

[0028] Further, clean air is provided by the air cleaning module to ensure the safety of each sperm washing operation, and the visual information storage on the sperm collection cup maintains the high consistency and traceability of the information. BRIEF DESCRIPTION OF DRAWINGS

[0029] Figure 1 A schematic diagram of a sperm automatic processing system provided by an embodiment of the application is provided.

[0030] Figure 2 A flowchart of a control method of a sperm automatic processing system provided by an embodiment of the application is provided.

[0031] Figure 3 A flowchart of a control method of a sperm automatic processing system provided by an embodiment of the application is provided.

[0032] Figure 4 A flowchart of a control method of a sperm automatic processing system provided by an embodiment of the application is provided.

[0033] Figure 5 A schematic diagram of the structure of an electronic device provided by an embodiment of the application is provided. DETAILED DESCRIPTION

[0034] In the following, the application will be further described in combination with the drawings and specific embodiments, and it should be noted that the following described embodiments or technical features can be combined to form new embodiments without conflict:

[0035] Embodiment one:

[0036] The professional terms are explained as follows:

[0037] RFID tag: contains RFID chip, and the tag surface supports printing visual text information;

[0038] Sperm cup: used to load the biological sample (semen) obtained from the patient, the upper side is attached with an RFID tag with patient information, and the tag has visual information of the patient, such as the names of the patient couple;

[0039] Centrifugal tube: the centrifugal tube is filled with gradient liquid or culture liquid, and the centrifugal tube is replaced as needed during the sperm washing process;

[0040] Please refer to Figures 1-5 , Figure 1 An automatic semen processing system of the application is shown, comprising:

[0041] The sperm cup processing module is used to read the RFID tag information on the sperm cup and check the RFID tag information according to the patient information in the medical record system;

[0042] In specific implementation, the sperm cup processing system is composed of a sperm cup rotating motor, a sperm cup seat installed on the rotating motor, an RFID card reader, and a camera suite; its function is to tilt the sperm cup at a certain angle to facilitate the suction of the semen sample; the patient information stored in the RFID chip on the sperm cup is read, and the label information on the sperm cup is photographed for archiving. The principle is to tilt the sperm cup seat at a certain angle, keep the sperm cup placed on the upper side at a certain angle, rotate the sperm cup seat by the rotating motor to drive the sperm cup to rotate to the specified position for RFID reading and label photographing.

[0043] In this embodiment, the computer host controls the RFID card reader to read the RFID tag information on the sperm cup, the computer host obtains the corresponding patient information from the case system according to the read information for checking, and after the checking is correct, the information is printed on the new RFID tag by the printer and written into the sample information by the RFID card writer, the new RFID tag is pasted on the centrifugal tube and the information in the RFID tag is read again by the RFID card reader for rechecking, and the visual information on the new RFID tag is photographed by the label camera for manual checking. The selected processing operation instruction in the computer host is sent to the main control board, and the main control board will perform the selected processing operation.

[0044] The printing and labeling module is used to print the RFID tag information after the RFID tag information is checked and found to be correct, and paste the printed RFID tag information on the first centrifugal tube; and used to write the RFID tag information read from the sperm cup into the printed RFID tag, or bind the card number information of the printed RFID tag with the RFID tag information read from the sperm cup;

[0045] In specific implementation, the printing and labeling system mainly consists of a thermal printing module and a labeling module; its function is to print sample information on a label and paste the label to a specified position of a centrifuge tube; its principle is that when the centrifuge tube is inserted into the printing and labeling system, the control system sends printing content and printing instructions to the printer, the printer starts printing after receiving the instructions, and the labeling mechanism starts working, so that the printed label is pasted to the specified position of the centrifuge tube.

[0046] a vision system for detecting a demarcation line between the first supernatant and the first precipitate in the first centrifuge tube after centrifugation;

[0047] a pipetting mechanism for transferring the semen sample in the pipette to the first centrifuge tube containing the gradient liquid, and taking out the first supernatant according to the demarcation line to obtain the first centrifuge tube with the first precipitate left;

[0048] In specific implementation, the pipetting mechanism can be realized by an XYZ three-axis system, which mainly consists of four groups of linear motion modules and an RFID reader / writer, wherein one group is for X-axis, one group is for Y-axis, and two groups are for Z-axis (one group is for mounting the cap clamping and opening / closing mechanism, and the other group is for mounting the pipetting mechanism); its function is to position the cap clamping and opening / closing mechanism and the pipetting mechanism to a specified position in the operation space to read and write the RFID tag of the centrifuge tube; its principle is to convert the circumferential rotation of the servo motor into linear motion by using a ball screw, and to position the cap clamping and opening / closing mechanism and the pipetting mechanism to a specified position by XYZ three-axis combination, so that when it is necessary to read and write the RFID tag of the centrifuge tube, the Z-axis clamps the centrifuge tube and lifts it to the vicinity of the RFID reader / writer to read and write the tag information.

[0049] a cap clamping and opening / closing mechanism for taking the first centrifuge tube out of the consumable area, and sending the first centrifuge tube containing the semen sample and the gradient liquid to the centrifuge to centrifuge the first centrifuge tube to obtain the first supernatant and the first precipitate; the printing and labeling module reads the RFID tag information on the first centrifuge tube taken out of the centrifuge, and uses the read RFID tag information as the information source for printing and writing / binding the RFID tag information when the tube is replaced; and the cap clamping and opening / closing mechanism is also used to move the first centrifuge tube containing the culture liquid and the first precipitate to the centrifuge tube rack.

[0050] In this embodiment, the cap clamping and opening / closing mechanism and the pipetting mechanism are mounted on the Z-axis of the XYZ three-axis mechanism, and the XYZ three-axis system can position the cap clamping and opening / closing mechanism and the pipetting mechanism to any position in the operation space; the cap clamping and opening / closing mechanism has the function of clamping the centrifuge tube in addition to the function of opening / closing the cap, and can transfer the centrifuge tube to a specified position in the operation space in cooperation with the three-axis mechanism.

[0051] The pipetting mechanism can be moved to a specified position along the XYZ axis to perform pipetting and dispensing. When performing a semen processing operation, the XYZ three-axis mechanism moves the cover opening / closing mechanism (cover opening / clamping) and the pipetting mechanism to a specified position to clamp the centrifuge tube or open the centrifuge tube cover, and adds or extracts solution from the centrifuge tube.

[0052] In this embodiment, the centrifugation of the first centrifuge tube is achieved by a centrifugal system mainly composed of two centrifuges. The centrifugal system is used to centrifuge the solution in the centrifuge tube. The principle is that the XYZ three-axis transfers the centrifuge tube to the centrifuge, the centrifuge sets the centrifugal force and centrifugal time according to the centrifugal parameters sent by the system, and then performs centrifugation. After centrifugation, the control system is notified to take the centrifuge tube out of the centrifuge.

[0053] In specific implementation, the functions of the cover opening / closing mechanism and the vision system are realized by a centrifuge tube clamping system mainly composed of two electric clamps and a camera system. The centrifuge tube clamping system is used to clamp the centrifuge tube, open / close the cover of the centrifuge tube with the cover opening / closing mechanism, take pictures of the label on the centrifuge tube for storage, and monitor the liquid level in the centrifuge tube. The principle is that the electric clamp holds the centrifuge tube to keep it still, the cover opening / closing mechanism holds the cover of the centrifuge tube to rotate and ascend to open the cover or rotate and descend to close the cover. The cover opening / closing mechanism puts the centrifuge tube into the electric clamp and ensures that the label is in the fixed area (in the camera's field of view), the camera takes pictures of the label and stores them. The camera analyzes the pictures of the liquid in the centrifuge tube to determine the relative position of the liquid level in the centrifuge tube.

[0054] The semen processing module is also used to read the visual information on the semen cup and store the visual information.

[0055] Optionally, the semen automatic processing system also includes an air cleaning module, which is used to provide clean air for the operation space of the semen automatic processing system, so that the cleanliness of the operation space of the semen automatic processing system reaches a preset level.

[0056] In specific implementation, the air cleaning module is mainly composed of a FFU (fan filter unit), which is used to provide clean air for the operation space of the machine to ensure that the cleanliness of the operation space is 100 (ISO 5) or above. The principle is that a high-power fan sucks indoor air and filters it through a primary high-efficiency filter, and then injects it into the operation space. The process ensures that the operation space forms and maintains a positive pressure, and prevents external non-clean air from entering the operation space.

[0057] Optionally, the semen automatic processing system of the present application further comprises an illumination disinfection system for sterilizing and disinfecting the operation space of the semen automatic processing system.

[0058] In the specific implementation, the illumination disinfection system mainly consists of LED day lamp tubes and ultraviolet lamp tubes; the day lamp tubes are used to provide illumination in the operation space, and the ultraviolet lamp tubes provide ultraviolet rays for sterilizing and disinfecting the operation space.

[0059] In the present embodiment, all semen processing operation processes are carried out in a hundred-level clean environment, and the main control board controls the air purification system to ensure the cleanliness of the working space; after the solution is added, the main control board controls the XYZ three-axis system and the cover opening mechanism (opening / holding) to put the centrifugal tube into the centrifuge for centrifugation and take it out after centrifugation; all the above operation processes will be recorded in the form of video by the monitoring system controlled by the computer host.

[0060] In the specific implementation, the system of the present application further comprises a consumable placement area and a waste collection system:

[0061] The consumable placement area mainly consists of a plurality of consumable placement seats; its function is to facilitate the placement and replacement of various consumables; its principle is that each consumable seat has four positioning pins (two on each side) and two elastic sheets (one on each side), and the consumable box / shelf is placed into the seat and positioned by the pins on the two sides (at an angle of 90°), and clamped by the elastic sheets on the other two sides (at an angle of 90°) to ensure that the consumables are placed in the designated position.

[0062] The waste collection system mainly consists of a waste collection port and a waste collection barrel; its function is to collect waste items during the processing process, such as waste liquid, waste centrifugal tube, and waste tip head; its principle is that the XYZ three-axis system transfers the waste to the waste collection port for disposal, and the thick waste falls into the waste collection barrel, which is covered with a plastic bag, and when the waste is full, the waste is packed and taken away for disposal through the plastic bag.

[0063] Optionally, the system of the present application is further provided with an alarm prompt system, which can alarm and prompt through sound and light or voice when the machine operation is abnormal during the operation process.

[0064] Embodiment two:

[0065] Please refer to Figure 2 The control method of the semen automatic processing system comprises the following steps:

[0066] Step S1: obtaining a semen sample through a semen cup processing module, and receiving a processing operation instruction for the semen sample sent by an upper computer;

[0067] Step S2: performing a semen processing operation procedure according to the processing operation instruction, the semen processing operation procedure comprising:

[0068] Step S21: information checking operation: reading the RFID tag information on the semen cup through the semen cup processing module, and checking the RFID tag information according to the patient information in the medical record system; after checking, taking out the first centrifugal tube consumable area through the cover opening and closing mechanism, printing the RFID tag information through the printing and labeling module, and pasting the printed RFID tag information on the first centrifugal tube;

[0069] Step S22: semen separation operation: transferring the semen sample in the semen cup to the first centrifugal tube containing gradient liquid through the pipetting mechanism, sending the first centrifugal tube containing the semen sample and gradient liquid to the centrifuge through the cover opening and closing mechanism, so that the centrifuge centrifuges the first centrifugal tube to obtain the first supernatant and the first precipitate; taking out the first centrifugal tube after centrifugation through the cover opening and closing mechanism, detecting the boundary line between the first supernatant and the first precipitate in the first centrifugal tube after centrifugation through the visual system, and taking out the first supernatant according to the boundary line through the pipetting mechanism to obtain the first centrifugal tube with the first precipitate left;

[0070] In this embodiment, when the supernatant is sucked, the visual system will first identify the boundary between the supernatant and the precipitate in the centrifugal tube, and the z-axis will lower the pipetting mechanism to a specified height according to the identification result of the visual system, and then suck the supernatant, so as to ensure that the supernatant can be sucked as clean as possible. The sucked supernatant is discharged to the waste collection area, and the discarded plastic consumables are also discarded to the waste collection area.

[0071] Step S23: semen culture operation: sucking the culture liquid into the first centrifugal tube containing the first precipitate through the pipetting mechanism, and moving the first centrifugal tube containing the culture liquid and the first precipitate to the centrifugal tube rack through the cover opening and closing mechanism.

[0072] Optionally, the information checking operation further comprises: reading the visual information on the semen cup through the semen cup processing module, and storing the visual information.

[0073] In specific implementation, the running state of the visual information monitoring system can be monitored in the upper computer to configure the number of centrifugation operation procedures and the semen processing operation procedure, adjust and set the system, and view the system log and other human-computer interaction functions. After the preparation work before washing semen is completed, for example, the corresponding consumables and solutions are placed at the specified positions of the consumable placement area. The upper computer selects the corresponding processing operation and sends it to the control system for execution.

[0074] Optionally, after the step of the pipetting mechanism removing the supernatant according to the boundary line to obtain the first centrifuge tube containing the remaining first precipitate, and before the semen culture operation step, the procedure further includes:

[0075] Step S24: Execute the centrifugation operation procedure once or multiple times according to the processing operation instruction; the centrifugation operation procedure includes: transferring the precipitate in the (n-1)th centrifuge tube to the nth centrifuge tube using a pipetting mechanism, where n is a natural number greater than 2; sending the nth centrifuge tube to the centrifuge using a cap-opening mechanism, so that the centrifuge centrifuge centrifuge centrifuge tube centrifuges to obtain the nth supernatant and the nth precipitate; removing the nth centrifuge tube after centrifugation using a cap-opening mechanism; detecting the boundary line between the nth supernatant and the nth precipitate in the nth centrifuge tube after centrifugation using a vision system; and removing the nth supernatant according to the boundary line using a pipetting mechanism to obtain the nth centrifuge tube containing the nth precipitate; the semen culture operation step includes: aspirating the culture medium into the nth centrifuge tube containing the nth precipitate using a pipetting mechanism.

[0076] In practice, the centrifugation process can be executed multiple times depending on the configuration of the host computer.

[0077] Optionally, in the control method of the automatic semen processing system of the present invention, the semen processing operation process further includes:

[0078] Solution preparation operation: Take the third centrifuge tube out of the consumables area through the cap opening and closing mechanism, transfer the preset solution in the preset solution bottle to the third centrifuge tube through the pipetting mechanism, and move the third centrifuge tube containing the preset solution to the centrifuge tube rack through the cap opening and closing mechanism.

[0079] The control method of an automatic semen processing system according to the present invention will be described below with reference to specific embodiments:

[0080] Please refer to Figure 3 As shown, Figure 3 This invention illustrates a control method for an automated semen processing system according to a specific embodiment, wherein a two-stage centrifugation process is executed based on the configuration of the host computer. When n=2, the second centrifuge tube (i.e., centrifuge tube B) that has completed centrifugation is removed via a cap-opening mechanism. A vision system detects the boundary between the second supernatant and the second precipitate in the second centrifuge tube (i.e., centrifuge tube B). A pipetting mechanism removes the second supernatant according to the boundary, resulting in a second centrifuge tube containing the second precipitate. The semen culture operation includes: using a pipetting mechanism to aspirate the culture medium into the second centrifuge tube containing the second precipitate.

[0081] Please refer to Figure 4 As shown in the figure, a control method for an automatic semen processing system according to a specific embodiment of the present invention also includes a solution preparation operation. Figure 4A flowchart of a liquid preparation operation included in a control method of a semen automatic processing system of the present application is shown, wherein a pipetting mechanism sucks solution from a solution bottle in a consumable placement area and transfers it to a centrifuge tube B, and the operation is repeated until the number of prepared solutions reaches the number of prepared solutions preset by the upper computer.

[0082] In the present embodiment, all these operation processes are carried out in a hundred-level clean environment, and the air purification system is started in advance to ensure that the operation environment maintains a hundred-level cleanliness. Specifically, the indoor air is sucked in through the primary filtration system and filtered through the high-efficiency filtration system by a high-power fan, and then injected into the operation space, and then discharged from the lower opening of the operation space to the indoor space. During the process, it is ensured that the operation space forms and maintains a positive pressure to isolate the external non-clean air from entering the operation space.

[0083] In the above implementation process, the present application receives the processing operation instruction for the semen sample sent by the upper computer, and then automatically completes the predetermined processing operation according to the processing operation instruction, such as information checking, semen separation, culture solution culture, etc. Only by cooperating with the machine, various semen washing operations can be automatically executed. At the same time, since the visual system is applied to detect the boundary line between the supernatant and the precipitate, and cooperates with the pipetting mechanism, it can ensure that the residual amount of supernatant is small and the loss of precipitate (sperm) is small after each supernatant is removed, thereby ensuring the maximum extraction of high-purity precipitate and solving the problem that the current assisted reproductive laboratory semen washing operation is easy to be not clean or sperm loss through manual semen washing. The operator is liberated from tedious repetitive work. Further, the clean air is provided by the air cleaning module to ensure the safety of each semen washing operation, and the visual information storage on the sperm collection cup maintains the high consistency and traceability of the information.

[0084] Embodiment three:

[0085] Figure 5 A structural schematic diagram of an electronic device provided for the embodiments of the present application can be described in the present application by Figure 5 The schematic diagram shown in the present application is used to describe the electronic device 100 of the control method of the semen automatic processing system of the present application.

[0086] As Figure 5 shown in a structural schematic diagram of an electronic device, the electronic device 100 includes one or more processors 102, one or more storage devices 104, and these components are interconnected through a bus system and / or other forms of connection mechanism (not shown). It should be noted that Figure 5 The components and structure of the electronic device 100 shown are only exemplary and are not limited, and the electronic device can have Figure 5 part of the components shown, or can have Figure 5Other components and structures are not shown.

[0087] The processor 102 can be a central processing unit (CPU) or other form of processing unit that has data processing and / or instruction execution capabilities, and can control other components in the electronic device 100 to perform desired functions.

[0088] The storage 104 can include one or more computer program products that can include various forms of computer-readable storage media, such as volatile and / or non-volatile computer-readable media. The volatile computer-readable media can include, for example, random access memory (RAM), cache memory, and / or the like. The non-volatile computer-readable media can include, for example, read-only memory (ROM), hard disks, flash memory, and / or the like. One or more computer program instructions can be stored on the computer-readable media, and the processor 102 can execute the program instructions to implement the functions (implemented by the processor) in the embodiments described below and / or other desired functions. Various application programs and various data, such as various data used and / or generated by the application programs, and the like, can also be stored in the computer-readable media.

[0089] The application also provides a computer storage medium having a computer program stored thereon, and the method of the application can be stored in the computer storage medium if the method is implemented in the form of a software function unit and sold or used as an independent product. Based on this understanding, the application can implement all or part of the processes in the above-described embodiments, and can also be completed by instructing related hardware through a computer program. The computer program can be stored in a computer storage medium, and the computer program can implement the steps of each method embodiment when executed by a processor. The computer program includes computer program code, which can be in the form of source code, object code, executable files, or some intermediate form, etc. The computer storage medium can include any entity or device capable of carrying the computer program code, recording medium, U disk, mobile hard disk, magnetic disk, optical disk, computer memory, read-only memory (ROM), random access memory (RAM), electrical carrier signal, telecommunication signal, and software distribution medium, etc. It should be noted that the computer storage medium can include or exclude content according to the requirements of legislation and patent practice in the jurisdiction, for example, in some jurisdictions, according to legislation and patent practice, the computer storage medium does not include electrical carrier signals and telecommunication signals.

[0090] For those skilled in the art, other various corresponding changes and modifications can be made to the above described technical solutions and concepts, and all these changes and modifications should belong to the protection scope of the claims of the present application.

Claims

1. A system for the automatic processing of semen, characterized in that The semen automatic processing system is in communication connection with the upper computer, and the semen automatic processing system comprises: A cup processing module is configured to read RFID tag information on a semen collection cup and check corresponding patient information in a medical record system according to the information; the cup processing module is further configured to read visual information on the semen collection cup and store the visual information; A printing and labeling module is configured to print patient information associated with the RFID tag after the RFID tag information is checked and found to be correct, and stick the printed RFID tag to a first centrifugal tube; the information in the RFID tag is read again by an RFID card reader, and the visual information on the new RFID tag is photographed by a label camera for manual checking; the printing and labeling module is further configured to write patient information obtained from the semen collection cup into the printed RFID tag, or bind the card number information of the printed RFID tag with the patient information obtained from the semen collection cup; A vision system is configured to detect a boundary line between first supernatant and first precipitate in the first centrifugal tube after centrifugation; A pipetting mechanism is configured to transfer the semen sample in the semen collection cup to the first centrifugal tube containing gradient liquid, and take out the first supernatant according to the boundary line to obtain the first centrifugal tube containing the first precipitate; An opening and closing cover mechanism is configured to take the first centrifugal tube out of a consumable area, and send the first centrifugal tube containing the semen sample and the gradient liquid to a centrifuge to centrifuge the first centrifugal tube by the centrifuge to obtain the first supernatant and the first precipitate; the printing and labeling module reads patient information associated with the RFID tag on the first centrifugal tube taken out of the centrifuge, and uses the read patient information as a source of information for printing and writing / binding the RFID tag when the tube is changed; the opening and closing cover mechanism is further configured to move the first centrifugal tube containing the culture liquid and the first precipitate to a centrifugal tube rack; An air cleaning module is configured to provide clean air for an operation space of the semen automatic processing system, so that the cleanliness of the operation space of the semen automatic processing system reaches a preset level.

2. The system for automatic processing of semen according to claim 1, characterized in that, Further comprising: An illumination disinfection system is configured to sterilize and disinfect the operation space of the semen automatic processing system.

3. A control method of the semen automatic processing system according to any one of claims 1 to 2, characterized by, The steps include: A semen sample is obtained by the cup processing module, and a processing operation instruction for the semen sample is received from the upper computer; A semen processing operation process is performed according to the processing operation instruction, and the semen processing operation process comprises: An information checking operation: the RFID tag information on the semen collection cup is read by the cup processing module, and the RFID tag information is checked according to the patient information in the medical record system; after the checking is correct, the first centrifugal tube is taken out of the consumable area by the opening and closing cover mechanism, the RFID tag information is printed by the printing and labeling module, and the printed RFID tag information is stuck to the first centrifugal tube; The semen separation operation: the semen sample in the semen collection cup is transferred to the first centrifuge tube containing gradient liquid by the pipetting mechanism, the first centrifuge tube containing the semen sample and the gradient liquid is sent to the centrifuge by the cap opening and closing mechanism, so that the centrifuge centrifuges the first centrifuge tube to obtain the first supernatant and the first precipitate; the first centrifuge tube after centrifugation is taken out by the cap opening and closing mechanism, the demarcation line between the first supernatant and the first precipitate in the first centrifuge tube after centrifugation is detected by the visual system, and the pipetting mechanism takes out the first supernatant according to the demarcation line to obtain the first centrifuge tube with the first precipitate left; The semen culture operation: the culture liquid is sucked into the first centrifuge tube containing the first precipitate by the pipetting mechanism, and the first centrifuge tube containing the culture liquid and the first precipitate is moved to the centrifuge tube rack by the cap opening and closing mechanism.

4. The control method of the semen automatic processing system according to claim 3, characterized by, The information checking operation further includes: reading the visual information on the semen collection cup by the semen cup processing module, and storing the visual information.

5. The control method of the semen automatic processing system according to claim 3, characterized by, The semen processing operation process further includes: The solution preparation operation: the third centrifuge tube is taken out from the consumable area by the cap opening and closing mechanism, the preset solution in the preset solution bottle is transferred to the third centrifuge tube by the pipetting mechanism, and the third centrifuge tube containing the preset solution is moved to the centrifuge tube rack by the cap opening and closing mechanism.

6. An electronic device, comprising: It includes: At least one processor and a memory connected to the at least one processor in communication, wherein the memory stores instructions executable by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to execute the control method of the semen automatic processing system according to any one of claims 3-5.

7. A computer storage medium having stored thereon a computer program, characterized in that The computer program, when executed by the processor, implements the control method of the semen automatic processing system according to any one of claims 3-5.

Images